Hub : Genes

Fndc3a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_006252298.5 0.03 0.02 4.6e-03 0.01 0.01 0.01 0.01 1.2e-02 1.2e-02 3.1e-02 3.1e-02
2 Liver alternative TSS XM_006252298.5 0.03 0.02 6.7e-03 0.01 0.01 0.01 0.01 1.6e-02 1.4e-02 4.6e-02 2.5e-02
3 Liver intron excision ratio chr15_54165210_54168980 0.03 0.02 4.0e-03 0 0.01 -0 0 2.0e-01 3.0e-02 5.3e-01 1.8e-01
4 pVTA gene expression Fndc3a 0.07 0.04 2.4e-05 0.02 0.04 0.04 0.04 5.8e-03 2.6e-04 2.8e-04 4.4e-04
5 Adipose mRNA stability Fndc3a 0.04 0.03 1.3e-04 0.03 0.03 0.03 0.03 2.1e-04 7.7e-04 3.0e-04 2.2e-04
6 IC gene expression Fndc3a 0.11 0.06 1.3e-04 0.11 0.1 0.1 0.1 2.0e-05 6.3e-05 4.9e-05 6.8e-05
7 Liver alternative TSS XM_039093358.1 0.04 0.03 1.1e-03 0.02 0.02 0.01 0.02 1.3e-03 2.1e-03 3.4e-02 2.3e-03
8 Liver isoform ratio XM_039093358.1 0.04 0.03 1.1e-03 0.03 0.02 0.01 0.02 7.9e-04 1.3e-03 1.4e-02 1.4e-03
9 Liver alternative TSS XM_039093358.1 0.05 0.03 1.1e-04 0.03 0.03 0.03 0.03 9.2e-05 1.5e-04 4.1e-04 9.3e-05
10 NAcc gene expression Fndc3a 0.12 0.05 0.0e+00 0.11 0.11 0.11 0.11 2.9e-16 3.1e-16 3.7e-16 1.9e-16
11 Adipose alternative TSS NM_001412039.1 0.03 0.02 3.4e-03 0 0.02 0.01 0.01 1.4e-01 4.9e-03 2.6e-02 6.4e-02
12 Adipose alternative TSS NM_001412039.1 0.03 0.02 3.2e-03 0 0.02 0.01 0.01 1.2e-01 4.1e-03 2.3e-02 6.3e-02
13 Brain gene expression Fndc3a 0.15 0.07 2.6e-12 0.12 0.14 0.14 0.14 2.1e-11 7.8e-13 3.0e-13 3.1e-13
14 Liver mRNA stability Fndc3a 0.02 0.02 4.2e-03 0.01 0 0 0 1.0e-02 8.0e-02 1.6e-01 7.2e-02
15 Adipose isoform ratio NM_001412039.1 0.03 0.02 5.1e-03 0 0.02 0.01 0.01 1.4e-01 5.2e-03 1.8e-02 5.2e-02
16 NAcc mRNA stability Fndc3a 0.03 0.02 5.5e-04 0.01 0.02 0.01 0.01 3.1e-02 1.6e-03 2.3e-03 1.2e-02
17 PL gene expression Fndc3a 0.1 0.06 9.4e-09 0.07 0.08 0.08 0.08 1.8e-08 3.9e-09 3.7e-09 6.1e-09
18 BLA gene expression Fndc3a 0.24 0.12 2.2e-08 0.11 0.13 0.12 0.13 2.7e-06 2.5e-07 1.0e-06 3.6e-07
19 Adipose gene expression Fndc3a 0.19 0.1 4.2e-11 0.05 0.09 0.08 0.07 1.8e-06 4.8e-10 2.1e-09 1.6e-08
20 BLA intron excision ratio chr15_54156388_54165134 0.23 0.15 5.7e-04 0.05 0.05 0.06 0.06 1.3e-03 7.6e-04 6.2e-04 2.4e-04
21 Liver gene expression Fndc3a 0.4 0.16 0.0e+00 0.17 0.29 0.28 0.28 3.6e-18 5.1e-32 6.2e-31 1.9e-31

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.20.31.20.60.5-0.70.7-1.00.4-0.4-0.4-0.40.40.60.60.4-0.40.60.70.30.0-0.1-1.1-0.1
Area under the delay curve0.40.51.51.01.0-1.01.0-0.80.6-0.7-0.7-0.70.50.30.30.4-1.20.30.20.20.20.20.3-0.8
BMI with tail0.10.41.4-0.6-0.51.0-1.01.2-0.10.00.00.10.0-0.3-0.20.30.9-0.2-0.30.20.60.80.70.9
BMI without tail0.30.83.3-1.2-1.21.5-1.51.2-0.60.60.60.6-0.5-0.2-0.20.31.8-0.1-0.10.30.30.5-0.21.5
Body weight0.10.41.30.40.6-0.10.20.50.7-0.8-0.8-0.80.70.20.20.5-0.40.2-0.00.51.01.11.10.1
Weight adjusted by age0.40.61.8-0.10.1-0.10.20.5-0.40.20.20.2-0.6-0.9-0.9-1.0-0.9-0.9-1.0-1.0-0.7-0.81.4-1.2
Bone surface0.30.61.41.01.0-1.21.2-1.10.7-0.7-0.7-0.70.70.70.70.4-1.00.60.70.30.20.0-0.7-0.6
Bone volume0.20.31.00.80.7-1.01.0-1.00.4-0.4-0.4-0.40.30.40.40.1-0.90.40.40.1-0.1-0.3-0.6-0.7
Breakpoint value in progressive ratio session1.31.63.0-1.1-1.10.7-0.70.8-1.31.41.41.4-1.6-1.4-1.4-1.40.1-1.4-1.4-1.5-1.7-1.70.5-0.8
Number of licking bursts0.10.20.9-0.2-0.20.4-0.40.20.2-0.1-0.1-0.10.30.40.40.70.70.40.40.70.70.8-0.40.9
Context. condit. distance diff. score1.92.39.5-2.0-2.02.5-2.51.5-0.91.01.01.0-0.6-0.0-0.00.63.10.20.30.80.50.9-1.12.9
Locomotion velocity, session 10.60.61.7-0.2-0.2-0.20.10.2-0.70.60.60.6-0.8-0.9-0.9-1.0-0.5-1.0-0.9-1.2-1.2-1.30.6-1.2
Locomotion distance, session 10.50.62.01.11.1-1.41.4-1.20.5-0.6-0.6-0.70.40.30.3-0.1-1.40.20.2-0.1-0.2-0.4-0.1-1.3
Locomotion velocity, session 20.40.51.41.00.9-1.21.2-1.00.6-0.5-0.5-0.50.50.40.40.1-1.10.30.3-0.0-0.1-0.2-0.2-0.9
Locomotion distance, session 21.31.86.11.81.8-2.32.3-1.70.9-0.9-0.9-0.90.60.40.4-0.3-2.50.20.3-0.5-0.5-0.80.0-2.3
Locomotion velocity, session 30.40.51.5-1.0-0.91.2-1.21.1-0.50.50.50.5-0.4-0.5-0.4-0.01.1-0.4-0.40.10.10.30.50.9
Locomotion distance, session 30.30.41.6-0.7-0.70.9-0.90.5-0.10.30.30.30.00.10.20.41.20.20.30.50.50.6-0.41.3
Stereotopy head waving bouts, day 30.70.81.5-0.5-0.50.3-0.30.7-0.80.80.80.8-0.9-1.0-1.0-1.2-0.4-1.1-1.1-1.2-1.0-1.01.1-0.8
Stereotopy head waving duration, day 31.01.23.5-0.4-0.30.2-0.10.9-0.80.80.80.8-1.0-1.3-1.3-1.4-0.8-1.4-1.5-1.4-1.1-1.11.9-1.3
Locomotion velocity, session 73.13.415.8-1.7-1.82.4-2.51.0-0.20.30.30.30.31.01.01.63.71.21.31.81.51.9-2.24.0
Locomotion distance, session 72.02.511.3-1.6-1.72.1-2.20.9-0.40.60.60.6-0.00.70.71.13.40.91.11.31.01.2-2.23.3
Stereotopy head waving bouts, day 70.30.31.50.60.7-0.60.7-0.10.4-0.5-0.5-0.50.3-0.1-0.1-0.1-1.1-0.2-0.3-0.10.10.11.2-0.9
Stereotopy head waving duration, day 70.30.32.60.20.4-0.30.30.30.1-0.1-0.1-0.1-0.1-0.6-0.6-0.4-1.0-0.6-0.7-0.5-0.2-0.11.6-1.0
Locomotion velocity, session 80.20.21.2-0.6-0.60.7-0.80.4-0.20.20.20.2-0.1-0.0-0.00.31.10.00.10.20.20.3-0.40.9
Locomotion distance, session 80.40.51.20.40.3-0.20.2-0.60.6-0.6-0.6-0.60.70.90.90.90.40.91.00.90.80.8-1.10.8
Degree of sensitization distance0.91.04.5-1.0-1.11.2-1.20.3-0.40.50.50.5-0.20.50.50.52.10.60.80.60.30.3-1.91.9
Degree of sensitization stereotypy0.20.20.80.40.5-0.30.4-0.00.5-0.5-0.5-0.50.40.00.00.2-0.6-0.0-0.10.20.40.40.9-0.4
Conditioned locomotion0.30.40.8-0.9-0.90.9-0.90.7-0.80.70.70.7-0.7-0.4-0.4-0.30.9-0.3-0.3-0.2-0.3-0.3-0.10.6
Cocaine response after cond. corrected2.32.84.1-2.0-2.01.9-1.92.0-1.92.02.02.0-1.9-1.6-1.6-1.51.3-1.5-1.4-1.4-1.5-1.40.50.4
Cocaine response after cond. not corrected0.80.91.6-1.2-1.21.2-1.21.3-1.11.11.11.1-1.0-0.9-0.9-0.70.9-0.8-0.8-0.7-0.7-0.60.30.4
Cocaine response before conditioning3.33.95.62.22.2-1.91.9-2.12.4-2.3-2.3-2.32.32.02.02.0-1.31.91.82.02.12.0-0.70.0
Saline control response0.60.81.61.21.2-1.31.3-1.31.0-0.8-0.8-0.81.00.90.90.7-1.00.80.80.70.60.4-0.5-0.5
Bone: connectivity density0.71.13.20.80.6-0.70.6-1.30.9-0.9-0.9-0.91.01.31.31.20.11.31.41.20.80.8-1.80.7
Bone: cortical apparent density1.01.44.0-1.7-1.71.8-1.91.4-1.31.11.11.1-1.1-0.7-0.7-0.42.0-0.6-0.5-0.4-0.5-0.3-0.31.3
Bone: cortical area0.20.30.80.70.7-0.80.8-0.70.5-0.4-0.4-0.40.50.40.40.2-0.90.30.30.30.20.1-0.1-0.5
Bone: cortical porosity1.92.13.91.82.0-1.71.8-1.31.7-1.7-1.7-1.71.61.11.11.1-1.81.00.81.11.41.30.7-0.8
Bone: cortical porosity1.71.83.71.81.9-1.81.8-1.41.6-1.5-1.5-1.51.40.90.90.8-1.90.80.70.81.00.90.6-1.0
Bone: cortical thickness0.20.30.50.60.5-0.50.5-0.60.6-0.6-0.6-0.60.60.70.70.6-0.30.60.60.70.60.6-0.40.2
Bone: cortical thickness0.40.51.4-1.0-1.01.1-1.20.7-0.60.70.70.7-0.5-0.3-0.3-0.21.2-0.2-0.2-0.1-0.1-0.0-0.21.0
Bone: cortical tissue density1.11.64.6-1.8-1.81.9-2.01.5-1.31.21.21.2-1.1-0.7-0.7-0.42.1-0.6-0.5-0.3-0.5-0.3-0.41.5
Condit. Reinf. active minus inactive responses0.70.81.51.21.2-1.11.1-0.71.0-1.2-1.2-1.20.90.60.60.5-1.10.60.50.50.80.70.4-0.6
Condit. Reinf. active-inactive response ratio0.40.51.7-0.5-0.40.5-0.50.9-0.60.50.50.5-0.6-0.8-0.8-0.8-0.1-0.8-0.9-0.7-0.5-0.41.3-0.3
Condit. Reinf. active responses2.22.84.52.02.0-1.81.8-1.62.0-2.1-2.1-2.11.91.61.61.5-1.31.51.41.41.71.6-0.3-0.3
Condit. Reinf. inactive responses4.75.77.82.72.7-2.62.6-2.82.7-2.7-2.7-2.72.72.52.52.4-1.42.42.42.22.11.9-1.7-0.1
Incentive salience index mean3.74.67.62.52.7-2.22.2-1.82.6-2.8-2.8-2.82.51.91.92.0-1.81.81.61.92.32.30.2-0.4
Condit. Reinf. lever presses6.08.413.13.23.4-2.72.8-2.53.5-3.6-3.6-3.63.42.82.83.0-1.92.72.52.93.33.2-0.40.0
Condit. Reinf. active minus inactive responses0.30.40.70.50.5-0.40.4-0.50.6-0.6-0.6-0.60.60.80.80.70.00.80.80.80.70.7-0.80.5
Condit. Reinf. active-inactive response ratio0.00.10.2-0.0-0.00.1-0.10.20.1-0.2-0.2-0.20.10.20.20.30.30.20.20.30.40.4-0.10.4
Condit. Reinf. active responses0.60.81.40.70.6-0.50.5-0.70.9-0.8-0.8-0.80.91.11.11.00.11.21.21.11.01.0-1.10.7
Condit. Reinf. inactive responses0.91.21.90.90.8-0.80.8-1.21.2-1.0-1.0-1.01.21.41.41.3-0.01.41.41.31.11.1-1.30.7
Condit. Reinf. lever presses2.43.34.82.12.2-1.91.9-1.82.2-2.1-2.1-2.12.11.81.81.9-1.31.71.61.71.81.7-0.5-0.2
Condit. Reinf. lever reinforcers received0.91.21.80.90.9-0.70.7-0.91.2-1.1-1.1-1.11.21.31.31.3-0.11.31.31.31.31.3-1.00.7
Conditioned reinforcement - actives0.30.51.6-0.8-1.00.9-0.90.2-0.60.70.70.8-0.5-0.1-0.10.31.30.00.10.2-0.3-0.3-1.21.0
Conditioned reinforcement - inactives3.14.56.52.22.1-2.02.0-2.52.3-2.2-2.2-2.12.32.42.42.3-0.82.42.42.32.01.8-2.10.5
Conditioned locomotion0.10.10.30.20.1-0.40.4-0.4-0.00.20.20.2-0.1-0.1-0.10.1-0.4-0.1-0.1-0.1-0.5-0.6-0.4-0.5
Patch foraging indifference point 0 sec4.27.89.73.13.0-2.72.7-2.83.1-3.1-3.1-3.03.13.13.13.1-1.23.02.92.82.92.7-2.10.4
Patch foraging indifference point AUC1.21.82.6-1.6-1.61.5-1.41.5-1.61.41.41.4-1.6-1.3-1.3-1.50.8-1.3-1.3-1.3-1.2-1.10.80.1
Delay disc. indifference point, 0s delay1.01.13.01.51.5-1.71.7-1.70.9-0.9-0.9-0.90.80.70.70.7-1.60.60.60.40.2-0.0-0.6-1.2
Delay disc. indifference point, 16s delay0.20.21.00.60.6-0.80.8-1.00.1-0.2-0.2-0.20.00.10.10.2-0.90.10.10.1-0.3-0.4-0.3-0.8
Delay disc. indifference point, 2s delay0.40.52.10.40.5-0.60.70.0-0.20.10.10.1-0.3-0.6-0.6-0.6-1.3-0.7-0.8-0.8-0.6-0.71.1-1.4
Delay disc. indifference point, 24s delay0.10.10.4-0.4-0.40.4-0.40.5-0.40.30.30.3-0.4-0.4-0.4-0.30.1-0.4-0.4-0.3-0.3-0.20.60.0
Delay disc. indifference point, 4s delay0.30.42.2-0.00.1-0.10.10.5-0.20.20.20.2-0.3-0.6-0.6-0.8-0.7-0.7-0.8-0.8-0.4-0.41.5-0.8
Delay disc. indifference point, 8s delay0.50.50.80.80.8-0.70.7-0.90.8-0.8-0.8-0.80.80.70.70.8-0.50.70.70.80.70.7-0.4-0.0
Indifference point function ln k1.42.53.61.71.7-1.41.4-1.41.9-1.8-1.8-1.81.91.61.61.8-0.61.61.41.71.81.8-0.50.2
Indifference point function log k1.42.53.61.71.7-1.41.4-1.41.9-1.8-1.8-1.81.91.61.61.8-0.61.61.41.71.81.8-0.50.2
Patch foraging total patch changes 0 sec3.87.19.03.03.0-2.72.7-2.83.0-2.9-2.9-2.93.02.92.92.8-1.32.82.72.62.72.5-1.90.2
Patch foraging total patch changes 12 sec1.21.62.61.61.5-1.61.6-1.51.3-1.4-1.4-1.41.31.31.30.9-1.11.21.20.80.90.7-0.9-0.4
Patch foraging total patch changes 18 sec0.20.31.70.30.2-0.20.2-0.50.3-0.3-0.3-0.30.40.70.70.70.30.80.80.70.50.4-1.30.6
Patch foraging total patch changes 24 sec0.91.52.51.51.6-1.41.5-1.11.4-1.4-1.4-1.41.31.11.11.1-1.21.11.01.01.21.1-0.1-0.4
Patch foraging total patch changes 6 sec0.91.32.90.60.6-0.20.3-0.61.1-1.1-1.1-1.01.21.31.31.60.41.41.31.61.71.7-0.91.3
Patch foraging time to switch 0 sec0.00.10.60.20.2-0.30.3-0.60.1-0.1-0.1-0.10.20.30.30.3-0.10.30.30.2-0.1-0.2-0.8-0.1
Patch foraging water rate 0 sec0.10.30.70.60.6-0.40.5-0.30.7-0.7-0.7-0.70.60.50.50.5-0.30.50.40.60.80.80.20.1
Patch foraging water rate 12 sec0.00.00.1-0.00.00.1-0.00.0-0.10.00.0-0.0-0.1-0.1-0.10.1-0.1-0.1-0.20.10.10.10.3-0.0
Patch foraging water rate 18 sec0.40.61.8-0.9-0.81.1-1.01.3-0.60.60.60.6-0.6-0.7-0.7-0.40.6-0.7-0.8-0.30.00.21.30.4
Patch foraging water rate 24 sec0.40.51.9-1.0-1.01.3-1.31.0-0.50.60.60.6-0.5-0.3-0.30.11.4-0.2-0.20.20.20.3-0.01.2
Patch foraging water rate 6 sec0.30.51.6-0.1-0.0-0.00.10.5-0.40.50.50.6-0.5-0.8-0.8-0.7-0.7-0.9-1.0-0.8-0.7-0.71.3-1.0
Seeking ratio, delayed vs. immediate footshock0.50.61.40.80.8-0.80.8-1.21.0-0.6-0.6-0.60.80.90.90.8-0.30.90.90.80.60.5-1.10.1
Distance traveled before self-admin0.81.13.60.10.2-0.60.60.1-0.60.60.60.6-0.9-1.1-1.1-1.5-1.4-1.2-1.2-1.4-1.4-1.51.1-1.9
Distance traveled after self-admin2.83.54.8-1.7-1.61.4-1.42.0-2.02.02.02.0-2.1-2.2-2.2-2.10.3-2.2-2.2-2.1-2.0-1.81.9-0.8
Extensor digitorum longus weight5.621.949.0-2.9-2.52.1-1.94.6-4.24.14.14.1-4.6-5.8-5.8-5.7-2.0-5.9-6.2-5.8-4.9-4.87.0-4.4
Bone: elastic displacement0.30.41.20.80.7-1.11.0-0.90.3-0.3-0.3-0.30.20.30.3-0.1-1.00.20.3-0.3-0.4-0.6-0.5-1.0
Bone: elastic work1.11.44.61.71.6-2.12.1-1.60.9-0.9-0.9-0.90.70.50.5-0.0-2.10.40.4-0.2-0.3-0.6-0.3-1.8
Bone: endosteal estimation0.10.21.00.60.7-0.70.7-0.20.4-0.4-0.4-0.40.30.00.0-0.2-1.0-0.0-0.1-0.20.0-0.00.6-0.8
Bone: endosteal perimeter0.10.31.40.70.8-0.90.9-0.50.4-0.4-0.4-0.40.30.00.0-0.2-1.2-0.1-0.1-0.2-0.1-0.20.5-1.0
Epididymis fat weight0.62.13.21.41.3-1.21.1-1.31.6-1.5-1.5-1.51.61.81.81.6-0.21.81.81.51.51.4-1.70.7
Delta time in closed arm before/after self-admin1.91.83.41.31.2-1.21.2-1.71.4-1.2-1.2-1.21.41.61.61.4-0.21.61.71.51.21.0-1.80.5
Delta time in open arm before/after self-admin0.10.10.2-0.3-0.20.3-0.30.4-0.20.10.10.1-0.3-0.4-0.4-0.30.0-0.4-0.4-0.3-0.3-0.20.4-0.1
Diff in mean of infusions in LGA sessions0.70.81.4-0.8-0.70.6-0.61.1-0.80.90.90.9-0.9-1.1-1.1-1.20.0-1.1-1.1-1.1-1.0-0.91.1-0.6
Delay discount exponential model param0.30.41.5-0.8-0.90.9-0.90.6-0.50.60.60.6-0.4-0.2-0.2-0.21.2-0.1-0.0-0.1-0.2-0.1-0.60.9
Extinction: sum of active levers before priming0.40.41.10.70.5-0.70.7-1.00.4-0.4-0.4-0.40.40.80.80.6-0.20.70.80.70.20.1-1.10.0
Active lever presses in extinction session 60.10.10.6-0.3-0.30.4-0.40.2-0.1-0.0-0.0-0.0-0.10.30.30.50.80.30.30.40.30.3-0.60.7
Bone: final force1.01.62.61.31.3-1.01.0-0.81.5-1.6-1.6-1.61.51.21.21.4-0.81.21.11.41.61.60.10.3
Bone: final moment1.11.72.71.51.6-1.31.3-1.11.6-1.6-1.6-1.61.61.21.21.2-1.11.21.11.21.51.40.1-0.1
Food consumed during 24 hour testing period0.50.71.31.11.1-1.11.1-1.11.0-0.9-0.9-0.90.90.80.80.7-0.90.80.70.60.60.5-0.4-0.4
Glucose0.71.11.9-1.4-1.41.4-1.31.2-1.21.31.31.3-1.1-0.8-0.8-0.81.1-0.8-0.7-0.7-0.7-0.60.30.6
Heart weight0.20.30.50.50.4-0.40.4-0.50.6-0.5-0.5-0.50.60.70.70.60.10.70.70.50.50.4-0.60.3
Delay discount hyperbolic model param0.30.31.5-0.7-0.80.8-0.80.4-0.40.50.50.5-0.3-0.0-0.0-0.11.20.00.10.1-0.1-0.0-0.70.9
Intermittent access intake day 1-15 change0.81.64.20.60.5-0.40.3-0.90.9-1.0-1.0-1.11.01.61.61.50.71.61.71.61.41.3-2.01.4
Intermittent access intake escalation1.12.34.31.10.9-0.80.8-1.21.2-1.4-1.4-1.41.41.91.91.90.42.02.01.91.71.6-2.11.3
Intermittent access intake escalation 20.70.81.90.10.00.1-0.1-0.20.4-0.6-0.6-0.60.61.11.11.01.01.21.21.11.01.0-1.41.4
Intermitt. access day 1 inactive lever presses0.10.31.4-0.2-0.20.6-0.60.40.3-0.2-0.2-0.20.40.40.50.70.90.50.50.70.91.0-0.11.2
Intermitt. access day 15 inactive lever presses0.51.01.71.01.0-0.80.9-0.61.1-1.1-1.1-1.21.11.21.21.2-0.11.21.11.11.31.2-0.40.4
Intermitt. access escalation Index0.00.10.1-0.1-0.1-0.00.00.0-0.30.20.20.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.4-0.40.3-0.4
Intermittent access day 1 total infusions0.20.30.50.60.6-0.50.5-0.40.7-0.6-0.6-0.60.70.60.60.7-0.30.60.60.60.60.6-0.10.1
Intermittent access day 15 total infusions1.72.64.11.41.3-1.11.1-1.41.5-1.6-1.6-1.51.72.02.01.90.02.02.01.91.81.6-1.71.0
Intermittent access terminal intake (last 3 days)0.81.01.90.50.4-0.20.2-0.40.8-0.8-0.8-0.81.01.31.31.30.71.31.41.31.21.2-1.31.2
Intermittent access total infusions1.21.42.50.80.7-0.50.5-0.81.1-1.0-1.0-1.01.21.51.51.60.41.51.51.61.41.4-1.31.1
Intermittent access day 1 locomotion1.41.83.01.31.4-1.01.1-0.91.6-1.5-1.5-1.51.71.51.51.7-0.41.51.41.61.71.7-0.40.5
Intermittent access day 15 total locomotion0.10.20.7-0.1-0.20.3-0.3-0.10.1-0.1-0.1-0.10.20.40.40.60.70.50.50.50.50.5-0.70.8
Intermittent access total locomotion0.70.91.50.80.8-0.60.6-0.51.0-0.9-0.9-0.91.11.11.11.2-0.01.11.01.21.21.2-0.60.6
Intermittent access standard deviation0.20.31.1-0.3-0.40.1-0.10.2-0.60.70.70.7-0.6-0.4-0.5-0.8-0.1-0.5-0.4-0.7-0.9-1.0-0.3-0.4
Left kidney weight1.46.610.12.83.0-2.42.4-2.03.2-3.2-3.2-3.13.22.52.52.5-1.62.42.22.53.13.0-0.10.1
Right kidney weight1.77.813.53.53.7-3.33.4-2.63.4-3.4-3.4-3.43.32.42.42.3-2.82.32.12.12.62.40.0-1.1
Cocaine induced anxiety1.31.85.62.02.0-2.22.2-1.61.4-1.3-1.3-1.31.10.70.70.4-2.40.50.50.10.30.00.3-1.8
Post-drug Anxiety2.02.13.81.91.9-1.91.9-1.71.6-1.6-1.6-1.61.51.41.31.2-1.51.31.21.01.00.8-0.8-0.7
Baseline Anxiety0.60.73.1-0.5-0.50.8-0.80.30.1-0.2-0.2-0.20.30.70.71.01.50.80.81.11.01.2-1.11.8
Tail length0.31.11.91.21.1-1.21.2-1.41.0-1.1-1.1-1.11.01.21.20.9-0.61.21.20.90.80.6-1.10.0
Length with tail0.31.13.01.51.5-1.51.6-0.91.1-1.2-1.2-1.21.00.60.60.3-1.70.50.40.30.60.50.5-1.1
Length without tail0.31.06.20.30.5-0.40.50.9-0.10.10.10.1-0.2-1.0-1.0-1.1-1.6-1.1-1.3-1.2-0.5-0.52.5-1.7
Times rat made contact with spout1.11.22.80.30.30.1-0.1-0.30.9-0.8-0.8-0.81.11.31.31.51.01.31.31.51.61.7-1.21.6
Lifetime Intake0.70.91.70.60.5-0.40.4-0.60.9-0.8-0.8-0.81.01.21.21.30.31.21.21.31.11.1-1.10.9
Liver weight, left0.91.56.61.51.7-1.71.8-0.70.8-1.0-1.0-1.00.6-0.1-0.1-0.3-2.6-0.2-0.4-0.40.0-0.11.8-2.2
Liver weight, right0.71.32.1-0.8-0.70.5-0.50.8-1.21.11.11.1-1.3-1.4-1.4-1.4-0.4-1.4-1.4-1.4-1.4-1.41.2-1.0
Locomotor activity2.64.018.42.52.6-3.23.2-1.81.1-1.0-1.0-1.00.6-0.2-0.2-0.9-4.3-0.5-0.6-1.2-0.9-1.41.7-4.0
Locomotor testing distance2.44.314.33.03.0-3.53.5-2.61.7-1.7-1.7-1.61.40.90.90.2-3.80.70.6-0.1-0.1-0.50.1-3.1
Locomotor testing rearing2.85.616.13.43.4-3.93.9-2.92.2-2.2-2.2-2.21.81.41.30.5-4.01.11.00.30.4-0.1-0.0-3.0
Locomotion in novel chamber0.60.82.01.11.1-1.21.2-1.40.9-0.9-0.9-0.90.80.90.90.7-0.90.80.90.70.50.4-0.7-0.4
Locomotion in novel chamber post-restriction0.40.60.9-0.7-0.70.6-0.50.8-0.80.80.80.8-0.9-0.9-0.9-0.9-0.0-0.9-1.0-0.9-0.8-0.80.9-0.4
Fecal boli incidents, locomotor time 10.30.52.00.50.6-0.70.70.10.1-0.1-0.1-0.1-0.0-0.5-0.5-0.6-1.4-0.6-0.7-0.7-0.5-0.51.4-1.4
Change in fecal boli incidents, locomotor task0.20.20.3-0.5-0.50.5-0.40.4-0.40.50.50.5-0.4-0.4-0.4-0.40.3-0.4-0.4-0.3-0.3-0.30.30.0
Time >=10cm from walls, locomotor time 11.61.72.41.41.3-1.31.2-1.41.5-1.4-1.4-1.41.51.41.41.5-0.61.41.41.31.21.1-1.00.2
Bouts of movement, locomotor time 11.51.84.4-1.4-1.31.5-1.42.1-1.21.21.21.2-1.2-1.5-1.5-1.30.7-1.4-1.6-1.3-0.8-0.61.8-0.0
Total resting periods, locomotor time 12.02.25.2-1.6-1.51.7-1.62.3-1.41.41.41.4-1.4-1.7-1.7-1.50.9-1.6-1.7-1.5-1.0-0.81.90.0
Rest time, locomotor task time 11.51.92.9-1.2-1.11.0-1.01.4-1.41.31.31.3-1.4-1.7-1.7-1.60.1-1.7-1.7-1.6-1.4-1.41.6-0.7
Distance moved, locomotor task time 11.21.84.30.70.6-0.50.4-1.21.0-1.1-1.1-1.11.21.61.61.80.61.71.71.91.41.4-2.11.3
Vertical activity count, locomotor time 10.10.31.50.60.5-0.90.9-1.20.0-0.2-0.2-0.2-0.00.20.20.3-0.80.20.20.1-0.4-0.7-0.9-0.8
Time >=10cm from walls, locomotor time 20.50.81.6-0.5-0.40.2-0.20.4-0.80.70.70.7-0.9-1.1-1.1-1.1-0.6-1.1-1.1-1.2-1.2-1.21.1-1.0
Bouts of movement, locomotor time 22.13.35.2-1.9-1.71.8-1.72.3-1.81.81.81.8-1.8-2.1-2.1-2.00.5-2.1-2.2-1.9-1.5-1.32.3-0.4
Total resting periods, locomotor time 21.73.15.5-1.8-1.61.7-1.62.2-1.71.61.61.6-1.8-2.1-2.1-1.90.4-2.0-2.1-1.8-1.4-1.22.3-0.5
Rest time, locomotor task time 21.11.41.9-1.2-1.21.1-1.11.4-1.31.21.21.2-1.3-1.4-1.4-1.20.5-1.3-1.3-1.2-1.1-1.11.2-0.3
Distance moved, locomotor task time 21.82.14.11.41.3-1.31.3-2.01.3-1.4-1.4-1.41.31.71.71.8-0.41.71.71.61.21.1-2.00.4
Vertical activity count, locomotor time 20.30.51.70.40.3-0.80.8-1.1-0.40.30.30.3-0.5-0.3-0.3-0.3-1.1-0.4-0.3-0.5-1.0-1.3-0.5-1.3
Light reinforcement 10.92.26.40.50.3-0.10.0-1.01.1-1.0-1.0-1.01.31.81.81.91.41.92.02.01.71.7-2.52.0
Light reinforcement 21.11.77.9-1.6-1.71.9-2.01.0-0.80.80.80.8-0.40.20.20.42.80.40.50.70.40.7-1.42.5
Bone: marrow area0.10.31.00.70.8-0.80.8-0.30.5-0.5-0.5-0.50.40.10.1-0.1-1.00.10.0-0.10.10.00.5-0.8
Bone: maximum diameter0.20.30.5-0.5-0.50.4-0.40.6-0.60.60.60.6-0.6-0.7-0.7-0.7-0.1-0.7-0.7-0.6-0.6-0.60.7-0.3
Bone: maximum force0.61.12.11.41.5-1.31.4-0.91.2-1.2-1.2-1.31.20.70.70.7-1.40.70.60.60.90.80.5-0.7
Bone: maximum moment0.81.53.31.71.7-1.71.7-1.21.4-1.4-1.4-1.41.20.80.80.6-1.80.80.60.60.80.70.4-1.0
Mean time between licks in bursts0.20.42.50.50.3-0.50.5-1.10.4-0.3-0.3-0.30.40.90.90.50.10.91.00.60.20.1-1.60.4
Mean num. licks in bursts0.00.00.10.20.1-0.20.1-0.20.2-0.2-0.2-0.20.20.30.30.10.10.30.30.10.10.1-0.30.1
Cd content in liver1.31.44.80.20.2-0.70.70.1-0.70.70.70.4-0.9-1.1-1.2-1.6-1.7-1.3-1.3-1.7-1.5-1.71.5-2.2
Co content in liver5.86.78.9-2.5-2.32.1-2.12.8-2.82.82.82.9-2.9-3.0-3.0-2.90.4-3.0-3.0-2.9-2.6-2.52.5-1.0
Cu content in liver0.30.40.6-0.7-0.60.6-0.60.7-0.70.70.70.8-0.7-0.7-0.7-0.70.2-0.7-0.7-0.7-0.6-0.50.6-0.1
Fe content in liver0.50.71.50.60.5-0.50.5-0.90.7-0.8-0.8-0.70.81.11.10.80.11.11.10.80.80.7-1.20.6
K content in liver1.61.63.40.40.30.1-0.1-0.61.1-1.0-1.0-1.01.21.41.41.71.01.51.51.81.71.8-1.31.8
Mg content in liver0.60.62.40.10.00.0-0.1-0.60.4-0.3-0.3-0.30.50.90.90.90.81.01.11.00.70.7-1.61.1
Mn content in liver0.30.31.4-0.4-0.60.2-0.2-0.3-0.60.60.60.7-0.6-0.1-0.1-0.40.5-0.10.1-0.3-0.8-0.9-1.20.1
Na content in liver2.12.26.32.12.2-2.22.2-1.61.6-1.6-1.6-1.61.40.70.70.6-2.50.60.40.50.70.50.8-1.7
Rb content in liver0.10.10.2-0.4-0.40.5-0.50.4-0.20.30.30.4-0.2-0.1-0.1-0.20.5-0.1-0.1-0.1-0.00.0-0.10.4
Se content in liver1.41.65.91.61.5-2.22.2-2.00.5-0.5-0.5-0.50.30.30.3-0.5-2.40.10.2-0.6-0.8-1.2-0.4-2.2
Sr content in liver0.50.51.5-0.2-0.3-0.10.10.0-0.70.60.60.6-0.8-0.7-0.7-0.8-0.4-0.7-0.7-0.9-1.1-1.20.1-0.9
Zn content in liver0.30.31.40.70.6-1.01.0-0.90.1-0.1-0.1-0.10.00.00.0-0.4-1.2-0.1-0.0-0.3-0.5-0.7-0.1-1.1
Bone: minimum diameter0.40.83.41.21.2-1.31.4-0.90.8-0.7-0.7-0.70.60.30.3-0.1-1.90.20.10.00.2-0.00.6-1.2
Time in familiar zone, hab. session 10.40.41.40.00.10.3-0.30.10.6-0.6-0.6-0.60.70.60.60.90.70.60.60.91.11.2-0.21.0
Time in novel zone, hab. session 14.74.76.4-2.0-2.01.6-1.62.0-2.42.52.52.5-2.5-2.4-2.4-2.50.5-2.4-2.3-2.5-2.5-2.41.5-0.9
Total zone transitions, hab. session 10.20.31.20.30.3-0.60.6-0.2-0.20.00.00.0-0.3-0.4-0.4-0.6-0.9-0.4-0.4-0.6-0.6-0.70.5-1.1
Total locomotion distance, hab. session 10.60.82.21.31.3-1.51.5-1.20.8-0.9-0.9-0.90.70.50.50.2-1.40.40.40.10.1-0.1-0.1-1.2
Locomotion velocity, hab. session 11.72.45.82.22.2-2.42.4-2.11.5-1.6-1.6-1.61.31.11.10.7-2.21.00.90.60.50.2-0.4-1.6
Time in familiar zone, hab. session 22.02.13.7-1.7-1.61.7-1.71.9-1.51.51.51.5-1.5-1.6-1.6-1.11.2-1.5-1.5-1.2-1.1-0.91.10.2
Time in novel zone, hab. session 20.20.20.70.70.6-0.80.8-0.90.4-0.3-0.3-0.30.30.40.40.0-0.80.40.40.10.0-0.1-0.3-0.5
Total zone transitions, hab. session 20.91.15.00.91.0-1.31.3-0.40.1-0.2-0.2-0.2-0.1-0.6-0.6-0.9-2.2-0.7-0.8-1.1-0.8-1.01.4-2.2
Total locomotion distance, hab. session 20.50.62.70.91.0-1.21.2-0.60.3-0.4-0.4-0.40.1-0.2-0.2-0.5-1.7-0.3-0.3-0.7-0.5-0.70.7-1.6
Locomotion velocity, hab. session 20.70.94.21.11.1-1.51.5-0.70.3-0.4-0.4-0.40.1-0.3-0.3-0.7-2.0-0.4-0.5-0.8-0.6-0.81.0-2.0
Novel to familiar place preference ratio0.90.91.51.01.0-1.01.0-1.21.1-0.9-0.9-0.91.11.11.11.0-0.51.11.10.90.80.7-1.00.1
Novelty place preference0.91.01.51.11.0-1.01.0-1.21.2-1.0-1.0-1.01.21.11.11.0-0.51.11.11.00.90.8-0.90.1
Time in novel zone, NPP test0.60.60.90.90.8-0.80.8-0.90.9-0.8-0.8-0.80.90.90.90.8-0.50.80.80.70.70.6-0.60.0
Total zone transitions, NPP test0.60.82.31.31.3-1.51.5-1.30.8-0.8-0.8-0.80.60.60.60.1-1.50.50.50.00.1-0.1-0.2-1.1
Total locomotion distance, NPP test1.52.14.81.91.7-2.12.0-2.21.4-1.4-1.4-1.41.31.51.50.8-1.41.41.50.80.60.3-1.5-0.7
Locomotion velocity, NPP test1.72.45.21.91.8-2.12.1-2.31.5-1.6-1.6-1.61.51.71.61.0-1.31.61.61.00.80.5-1.5-0.6
Intraocular pressure0.20.30.90.30.2-0.20.2-0.50.4-0.5-0.5-0.50.40.70.70.50.30.70.80.50.50.5-0.90.5
Delta distance traveled before/after self-admin3.53.87.8-2.5-2.42.7-2.62.8-2.02.02.02.0-1.8-1.9-1.9-1.32.0-1.8-1.8-1.3-1.0-0.71.70.9
Delta ambulatory time before/after self-admin2.12.65.8-2.0-1.82.1-2.02.4-1.61.61.61.6-1.5-1.7-1.6-1.31.4-1.6-1.6-1.3-0.9-0.61.70.5
Parametrial fat weight0.81.84.30.60.5-0.30.2-1.21.1-1.1-1.1-1.11.21.61.61.80.81.71.71.81.41.5-2.11.5
Pavlov. Cond. lever latency2.63.25.0-1.7-1.81.3-1.31.4-2.12.12.12.1-2.2-1.9-1.9-2.20.5-1.8-1.7-2.1-2.2-2.20.8-0.6
Pavlov. Cond. magazine entry latency0.60.71.50.50.5-0.20.2-0.50.9-0.9-0.9-0.90.90.90.91.20.21.00.91.21.21.2-0.60.8
Pavlov. Cond. change in total contacts1.21.32.01.31.4-1.11.1-0.91.4-1.4-1.4-1.41.40.90.91.2-1.00.90.71.11.31.30.3-0.2
Pavlov. Cond. index score2.33.04.91.61.7-1.21.2-1.32.0-2.1-2.1-2.12.11.71.72.1-0.51.71.62.02.22.2-0.50.6
Pavlov. Cond. latency score3.03.96.61.81.9-1.31.3-1.42.3-2.3-2.3-2.32.42.02.02.5-0.42.01.92.42.52.6-0.70.8
Pavlov. Cond. lever contacts3.34.06.31.81.9-1.41.4-1.62.3-2.3-2.3-2.32.42.12.12.5-0.42.12.02.42.52.5-0.90.8
Pavlov. Cond. magazine entry number0.30.30.8-0.5-0.50.3-0.30.3-0.70.70.70.7-0.7-0.5-0.5-0.70.2-0.5-0.4-0.7-0.9-0.9-0.2-0.2
Pavlov. Cond. intertrial magazine entries1.72.03.01.71.7-1.61.6-1.51.7-1.7-1.7-1.71.61.31.31.3-1.21.31.21.21.41.3-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.2.02.44.11.51.6-1.11.1-1.11.9-1.9-1.9-1.91.91.51.51.9-0.51.51.41.82.02.0-0.30.5
Pavlov. Cond. response bias0.70.81.70.80.8-0.50.5-0.61.1-1.1-1.1-1.11.10.90.91.2-0.20.90.81.21.31.3-0.20.4
Pavlov. Cond. lever latency1.62.14.4-2.0-2.12.0-2.11.4-1.71.61.61.6-1.6-0.9-0.9-1.02.1-0.8-0.7-0.7-1.0-0.8-0.51.3
Pavlov. Cond. magazine entry latency1.41.73.11.71.8-1.71.7-1.41.5-1.6-1.6-1.61.41.11.11.0-1.41.00.90.80.90.8-0.1-0.8
Pavlov. Cond. change in total contacts0.50.83.50.70.9-1.01.0-0.20.2-0.1-0.1-0.1-0.0-0.6-0.6-0.7-1.9-0.7-0.8-0.8-0.6-0.71.5-1.8
Pavlov. Cond. index score1.21.64.51.81.9-1.91.9-1.21.4-1.4-1.4-1.41.20.60.60.6-2.10.50.30.30.60.40.8-1.5
Pavlov. Cond. latency score1.52.04.72.02.1-2.12.1-1.41.6-1.6-1.6-1.61.40.80.80.8-2.20.70.50.50.70.60.6-1.5
Pavlov. Cond. lever contacts1.62.24.62.12.2-2.12.1-1.61.8-1.6-1.6-1.61.61.01.01.0-2.10.90.70.70.90.80.4-1.3
Pavlov. Cond. magazine entry number0.91.12.0-1.4-1.41.3-1.31.1-1.31.31.31.3-1.2-0.9-0.9-0.91.1-0.8-0.7-0.8-0.9-0.8-0.00.5
Pavlov. Cond. intertrial magazine entries2.23.38.90.90.7-0.60.5-1.61.5-1.4-1.4-1.41.62.32.32.21.02.42.52.32.01.9-3.02.0
Pavlov. Cond. lever-magazine prob. diff.1.01.43.91.61.7-1.71.7-1.11.3-1.3-1.3-1.31.10.50.50.5-2.00.40.30.30.60.50.9-1.4
Pavlov. Cond. response bias1.52.14.82.02.1-2.12.1-1.51.6-1.6-1.6-1.61.50.80.80.8-2.20.70.60.50.80.60.5-1.5
Time in closed arm before self-admin0.10.20.7-0.5-0.40.6-0.60.7-0.30.10.10.1-0.0-0.4-0.4-0.10.2-0.3-0.4-0.10.20.40.90.3
Time in closed arm after self-admin0.10.10.30.10.1-0.00.0-0.10.3-0.3-0.3-0.30.50.30.30.40.10.30.30.30.50.5-0.10.4
Time in open arm before self-admin0.20.20.7-0.2-0.20.00.00.2-0.30.60.60.6-0.5-0.5-0.5-0.60.1-0.5-0.5-0.6-0.7-0.80.2-0.6
Time in open arm after self-admin0.10.10.3-0.2-0.20.1-0.10.2-0.30.40.40.4-0.5-0.4-0.4-0.40.1-0.4-0.4-0.3-0.5-0.50.0-0.3
Bone: periosteal estimation0.10.21.10.60.6-0.70.7-0.40.4-0.3-0.3-0.30.30.10.1-0.2-1.00.0-0.0-0.1-0.0-0.10.4-0.8
Bone: periosteal perimeter0.10.10.50.30.3-0.40.4-0.20.1-0.0-0.0-0.00.0-0.1-0.1-0.3-0.7-0.2-0.2-0.2-0.2-0.30.4-0.6
Bone: post-yield work0.20.31.2-0.6-0.60.7-0.70.4-0.20.20.20.2-0.10.20.20.31.10.20.20.40.30.4-0.51.0
Progressive ratio test 1 active lever presses0.30.31.0-0.8-0.81.0-1.00.8-0.30.40.40.4-0.3-0.2-0.20.21.0-0.2-0.20.10.10.2-0.10.9
Progressive ratio test 1 breakpoint0.30.41.1-0.9-0.91.0-1.10.9-0.40.50.50.5-0.4-0.4-0.40.11.0-0.3-0.30.0-0.00.1-0.00.8
Progressive ratio test 1 inactive lever presses0.60.93.3-0.3-0.40.7-0.60.10.3-0.2-0.2-0.20.50.90.91.31.51.01.01.31.11.2-1.31.8
Progressive ratio test 2 active lever presses0.30.31.4-0.6-0.60.8-0.90.7-0.20.20.20.2-0.00.10.20.51.10.20.20.50.40.6-0.31.2
Progressive ratio test 2 breakpoint0.20.21.1-0.4-0.40.7-0.70.6-0.00.00.00.10.10.20.20.50.90.30.30.50.50.6-0.31.0
Progressive ratio test 2 inactive lever presses0.50.81.80.50.4-0.20.1-0.41.0-0.8-0.8-0.81.01.11.11.20.41.11.11.21.31.3-0.81.1
Incentive Sensitization - Responses0.20.20.60.00.00.1-0.1-0.10.3-0.3-0.3-0.20.30.50.50.70.50.60.60.70.60.7-0.50.8
Incentive Sensitization - Breakpoint0.30.30.70.20.2-0.00.0-0.30.4-0.5-0.5-0.40.50.70.70.90.40.70.70.80.80.8-0.60.8
Sum of active levers in priming session hrs 5-62.32.13.5-1.8-1.91.7-1.61.4-1.81.81.81.8-1.8-1.3-1.3-1.21.4-1.2-1.1-1.1-1.4-1.4-0.00.4
Progressive ratio1.01.52.4-1.5-1.51.4-1.41.2-1.41.51.51.5-1.5-1.2-1.2-1.01.2-1.1-1.0-1.0-1.2-1.10.10.3
Food seeking constrained by brief footshock10.512.817.5-4.2-4.23.8-3.93.7-4.14.14.14.1-4.1-3.8-3.8-3.22.4-3.7-3.5-3.3-3.6-3.31.80.1
Seeking ratio, punishment vs. effort0.40.61.3-0.8-0.70.8-0.80.9-0.70.70.70.7-0.7-0.9-0.9-0.70.1-0.9-0.9-0.7-0.6-0.51.2-0.1
Retroperitoneal fat weight0.41.74.30.40.40.1-0.2-0.31.1-1.2-1.2-1.11.31.41.41.81.01.51.51.81.92.1-1.21.8
Reaction time number correct1.83.55.2-2.2-2.22.0-2.01.9-2.12.32.32.3-2.1-1.9-1.9-1.81.3-1.8-1.8-1.7-1.7-1.61.00.2
Reaction time mean minus median0.51.24.31.51.6-1.71.7-1.20.9-1.0-1.0-1.10.70.20.20.1-2.10.10.0-0.1-0.0-0.20.7-1.8
Reaction time mean minus median AUC0.20.51.40.91.0-1.01.0-0.70.7-0.8-0.8-0.80.50.20.20.3-1.20.20.10.10.20.20.5-0.9
Reaction time num false alarms0.20.20.50.60.7-0.60.6-0.40.6-0.5-0.5-0.50.60.40.40.5-0.70.30.30.40.50.40.1-0.3
Reaction time num false alarms AUC0.20.30.50.60.6-0.50.5-0.40.7-0.5-0.5-0.50.70.50.50.6-0.40.50.50.60.70.6-0.10.0
Reaction time trials correct on left1.83.55.2-2.2-2.22.0-2.01.9-2.12.32.32.3-2.1-1.9-1.9-1.81.3-1.8-1.8-1.7-1.7-1.61.00.2
Reaction time trials on left1.73.35.0-2.1-2.12.0-1.91.9-2.02.22.22.2-2.0-1.8-1.8-1.71.3-1.7-1.7-1.6-1.7-1.60.80.2
Reaction time mean0.61.03.31.31.4-1.51.5-1.10.9-1.0-1.0-1.00.80.30.30.2-1.80.20.10.00.20.10.7-1.4
Reaction time mean AUC0.61.03.91.31.4-1.51.5-1.00.8-0.8-0.8-0.90.60.10.1-0.0-2.0-0.0-0.1-0.2-0.1-0.20.9-1.7
Median of all reaction times0.40.51.81.01.0-1.11.0-0.80.7-0.7-0.7-0.80.60.20.20.2-1.40.10.10.00.20.10.6-1.0
Reaction time omissions0.40.61.70.70.6-0.80.7-1.10.7-0.7-0.7-0.70.81.01.00.9-0.11.01.00.80.50.4-1.30.2
Reaction time false alarm rate1.11.52.11.31.3-1.11.1-1.11.4-1.4-1.4-1.41.41.31.31.4-0.71.21.21.31.41.3-0.60.2
Reaction time premature initiation rate0.71.02.2-1.3-1.21.4-1.41.5-0.91.01.01.0-0.7-1.0-1.0-0.61.0-0.9-1.0-0.5-0.3-0.11.10.5
Reaction time premature initiations2.03.66.2-2.4-2.32.5-2.42.5-2.02.22.22.2-1.8-1.9-1.9-1.51.7-1.8-1.8-1.3-1.2-1.01.50.7
Std. dev. reaction times0.40.72.81.11.1-1.31.2-0.90.6-0.8-0.8-0.80.40.00.0-0.1-1.7-0.1-0.1-0.3-0.2-0.30.8-1.5
Reaction time trials completed1.73.35.0-2.1-2.12.0-1.91.9-2.02.22.22.2-2.0-1.8-1.8-1.71.3-1.7-1.7-1.6-1.7-1.60.80.2
Reaction time trials AUC1.73.35.1-2.1-2.11.9-1.91.8-2.12.22.22.2-2.0-1.8-1.8-1.71.3-1.7-1.7-1.6-1.7-1.60.80.2
Run reversals in cocaine runway, females0.20.22.0-0.0-0.2-0.10.0-0.6-0.2-0.0-0.0-0.0-0.10.40.40.30.50.40.60.3-0.2-0.3-1.40.4
Run reversals in cocaine runway, males0.50.52.10.30.4-0.50.60.00.0-0.0-0.0-0.0-0.2-0.6-0.6-0.8-1.1-0.7-0.8-0.9-0.5-0.61.4-1.4
Latency to leave start box in cocaine runway0.91.02.2-0.5-0.50.2-0.20.4-0.81.11.11.1-1.2-1.1-1.2-1.3-0.5-1.2-1.2-1.3-1.4-1.50.9-1.1
Latency to leave start box in cocaine runway, F0.91.01.8-0.5-0.40.2-0.20.7-0.80.90.90.9-1.1-1.2-1.2-1.3-0.6-1.2-1.3-1.3-1.2-1.31.3-1.1
Latency to leave start box in cocaine runway, M0.40.41.3-0.3-0.3-0.00.0-0.3-0.50.80.80.8-0.8-0.6-0.6-0.6-0.3-0.6-0.6-0.7-1.1-1.2-0.1-0.7
Std. dev. time between licks in bursts3.64.98.82.82.7-2.82.8-3.02.4-2.3-2.3-2.32.32.32.21.7-2.12.12.11.81.61.3-1.4-0.7
Total sessions with >9 infusions0.20.30.50.50.6-0.40.4-0.30.6-0.6-0.6-0.60.60.50.50.7-0.30.50.50.60.60.6-0.10.1
Short access day 1 total inactive lever presses1.41.93.21.81.8-1.81.8-1.51.5-1.6-1.6-1.61.41.31.31.1-1.51.21.11.01.10.9-0.4-0.6
Short access day 10 total inactive lever presses0.00.10.3-0.0-0.00.1-0.10.10.1-0.2-0.2-0.20.20.40.40.30.50.40.40.30.40.4-0.40.5
Short access day 1 total infusions0.10.10.40.30.3-0.20.2-0.20.5-0.4-0.4-0.40.50.40.40.6-0.10.40.30.50.50.5-0.00.2
Short access day 10 total infusions0.30.41.90.90.9-1.01.0-0.50.5-0.5-0.5-0.50.40.10.10.0-1.4-0.0-0.0-0.1-0.1-0.20.6-1.1
Short access total infusions0.10.10.20.40.5-0.40.4-0.20.5-0.4-0.4-0.40.50.30.30.4-0.40.30.30.30.30.30.1-0.1
Short access day 1 locomotion0.70.83.51.31.4-1.41.5-0.70.9-0.7-0.7-0.70.70.20.10.2-1.90.0-0.1-0.00.1-0.10.9-1.5
Short access day 10 total locomotion0.40.81.21.11.1-1.01.0-0.91.1-1.0-1.0-1.01.00.80.71.0-0.90.70.70.80.80.7-0.2-0.3
Short access total locomotion1.01.22.31.51.5-1.51.5-1.11.3-1.2-1.2-1.21.20.80.81.0-1.50.70.60.70.80.70.2-0.8
One hour access (0.3 mA shock)0.40.40.80.70.7-0.80.7-0.70.7-0.6-0.6-0.50.70.70.70.6-0.30.70.70.60.40.3-0.9-0.0
Compulsive drug intake2.02.43.31.71.7-1.51.6-1.41.7-1.8-1.8-1.71.81.71.71.3-0.81.71.61.51.71.5-0.90.2
One hour access (shock baseline)0.20.30.7-0.5-0.50.3-0.30.3-0.50.70.70.7-0.6-0.6-0.6-0.40.0-0.6-0.5-0.5-0.8-0.80.0-0.3
Social response proportion2.52.85.9-2.3-2.32.4-2.42.1-1.71.81.81.9-1.6-1.4-1.4-1.02.1-1.3-1.2-1.0-1.0-0.70.51.2
Social responses0.30.41.6-0.6-0.70.8-0.80.3-0.20.40.40.4-0.10.20.20.41.30.30.40.40.20.3-0.91.2
Social time0.81.11.81.31.3-1.31.3-1.21.2-1.1-1.1-1.21.21.11.10.8-1.01.01.00.70.80.7-0.5-0.3
Soleus weight4.212.519.8-2.8-2.82.0-2.02.7-3.93.83.83.9-4.1-4.0-4.0-4.4-0.2-4.0-3.9-4.3-4.4-4.42.7-2.3
Bone: stiffness0.71.22.21.11.3-0.90.9-0.51.4-1.4-1.4-1.41.30.90.91.1-0.90.80.71.11.41.50.7-0.0
Tibialis anterior weight3.311.127.8-1.7-1.41.1-0.93.1-2.82.72.72.8-3.2-4.1-4.1-4.1-2.0-4.2-4.5-4.2-3.5-3.55.3-3.6
Time to tail flick, vehicle, before self-admin0.80.91.50.40.4-0.10.2-0.60.7-0.9-0.9-0.90.91.21.21.00.61.21.21.21.21.2-1.21.2
Time to tail flick, vehicle, after self-admin3.64.88.7-2.8-2.72.8-2.82.9-2.42.32.32.3-2.3-2.1-2.1-2.01.9-2.0-2.0-1.8-1.6-1.31.40.8
Time to tail flick, test, before self-admin2.12.12.91.41.4-1.31.2-1.71.6-1.6-1.6-1.61.61.71.71.5-0.41.71.71.41.41.3-1.40.5
Time to tail flick, test, after self-admin1.21.23.8-0.1-0.20.4-0.5-0.00.4-0.5-0.5-0.50.81.21.21.41.41.31.41.51.31.4-1.72.0
Delta time to tail flick, vehicle, before/after SA2.62.53.8-1.9-1.91.9-1.91.9-1.81.81.81.8-1.7-1.6-1.6-1.31.2-1.5-1.4-1.3-1.3-1.20.90.4
Delta time to tail flick, test, before/after SA1.11.14.0-1.4-1.51.7-1.71.4-1.00.90.90.9-0.6-0.2-0.2-0.02.0-0.1-0.10.20.10.3-0.51.7
Tibia length7.921.730.85.15.1-4.64.5-4.75.5-5.5-5.5-5.65.54.94.94.8-2.54.84.64.54.84.5-2.40.3
Ambulatory time before self-admin0.40.62.00.10.2-0.50.50.0-0.50.40.40.4-0.7-0.8-0.8-1.0-1.1-0.8-0.8-0.9-1.1-1.20.7-1.4
Ambulatory time after self-admin3.54.16.6-1.4-1.31.1-1.02.0-2.01.91.91.9-2.2-2.5-2.5-2.5-0.4-2.5-2.6-2.4-2.2-2.22.5-1.6
Bone: tissue strength0.70.71.11.01.0-1.01.0-0.81.0-1.0-1.0-0.90.90.80.80.8-0.70.80.70.70.80.7-0.3-0.2
Total heroin consumption1.11.32.7-0.6-0.60.3-0.20.9-1.11.11.11.1-1.3-1.3-1.3-1.5-0.2-1.4-1.3-1.6-1.6-1.70.9-1.2
Bone: trabecular number0.50.82.50.80.7-0.80.8-1.30.8-0.8-0.8-0.80.81.11.10.9-0.21.11.20.90.60.5-1.60.4
Bone: trabecular spacing0.70.92.5-0.7-0.60.6-0.61.2-0.80.80.80.8-0.9-1.2-1.2-1.1-0.2-1.2-1.2-1.1-0.8-0.71.6-0.6
Bone: trabecular thickness0.60.71.30.90.9-1.00.9-1.10.8-0.9-0.9-0.90.81.01.00.8-0.51.01.00.70.60.5-1.10.0
Bone: trabecular tissue density0.71.02.5-0.4-0.30.1-0.10.7-0.80.80.80.8-1.0-1.2-1.2-1.4-0.8-1.2-1.3-1.3-1.1-1.11.6-1.2
Water consumed over 24 hours0.10.11.00.10.2-0.10.10.30.00.10.10.1-0.1-0.4-0.4-0.2-0.6-0.4-0.5-0.3-0.1-0.11.0-0.6
Number of responses in last shaping day0.50.61.0-0.6-0.60.5-0.40.6-0.80.90.90.8-0.8-0.9-0.9-0.80.1-0.9-0.9-0.8-0.8-0.91.0-0.5