Hub : Genes

Fn3k

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC mRNA stability Fn3k 0.16 0.09 3.3e-03 0.11 0.02 0.04 -0.01 1.7e-03 1.2e-01 3.8e-02 4.7e-01
2 IL mRNA stability Fn3k 0.13 0.09 9.5e-03 0.05 0.02 -0.01 -0 2.0e-02 1.1e-01 6.0e-01 3.5e-01
3 PL mRNA stability Fn3k 0.12 0.06 3.8e-12 0.13 0.12 0.11 0.13 1.8e-14 2.4e-13 3.4e-12 8.5e-14
4 Brain alternative polyA NM_001109051.2 0.06 0.04 6.8e-05 0.06 0.04 0.04 0.05 5.9e-06 1.1e-04 1.1e-04 2.6e-05
5 NAcc mRNA stability Fn3k 0.06 0.03 4.9e-06 0.05 0.04 0.04 0.04 6.3e-07 1.3e-05 1.3e-05 6.8e-06
6 Brain gene expression Fn3k 0.08 0.05 4.6e-05 0.05 0.05 0.04 0.05 1.1e-05 1.4e-05 4.4e-05 1.4e-05
7 Brain mRNA stability Fn3k 0.1 0.05 4.5e-10 0.12 0.11 0.12 -0 2.5e-11 2.7e-10 1.1e-11 8.1e-01
8 OFC gene expression Fn3k 0.36 0.17 1.2e-03 0 0.01 0.03 0.03 2.8e-01 2.1e-01 7.2e-02 6.8e-02
9 PL gene expression Fn3k 0.03 0.02 8.6e-03 0.01 0.01 0.01 0.01 7.1e-03 2.8e-02 5.1e-02 7.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.40.9-0.6-0.6-0.6-0.6-0.6-0.3-0.8-0.90.6
Area under the delay curve1.51.62.71.71.51.61.51.5-0.31.30.6-0.5
BMI with tail0.41.43.7-1.3-1.3-1.2-1.2-1.2-1.9-0.60.4-0.8
BMI without tail4.89.913.1-3.3-3.3-3.3-3.2-3.22.1-3.0-3.62.9
Body weight2.08.613.3-3.6-3.7-3.6-3.5-3.5-2.0-2.9-1.1-0.6
Weight adjusted by age2.22.55.2-2.3-2.1-2.2-1.5-1.5-0.9-1.5-0.5-0.9
Bone surface0.50.92.0-0.9-0.9-0.9-0.8-0.80.6-1.2-1.40.9
Bone volume0.40.71.5-0.8-0.8-0.8-0.7-0.70.2-1.1-1.20.9
Breakpoint value in progressive ratio session1.11.21.81.11.21.11.41.4-1.10.61.1-0.7
Number of licking bursts0.40.40.9-0.7-0.7-0.7-0.6-0.60.2-0.6-0.61.0
Context. condit. distance diff. score1.11.43.2-0.9-0.9-0.9-0.9-0.91.1-1.0-1.81.7
Locomotion velocity, session 12.22.43.91.51.51.51.41.4-1.31.22.0-1.9
Locomotion distance, session 10.81.01.81.21.21.21.21.2-0.51.30.0-0.2
Locomotion velocity, session 23.74.36.22.42.42.42.32.3-1.12.51.6-0.9
Locomotion distance, session 20.10.10.40.20.20.20.00.0-0.60.4-0.50.4
Locomotion velocity, session 32.63.13.61.91.91.91.81.8-1.41.71.6-1.7
Locomotion distance, session 34.04.45.62.42.42.32.32.3-1.42.41.7-1.2
Stereotopy head waving bouts, day 30.40.41.60.40.40.40.50.5-0.80.40.9-1.3
Stereotopy head waving duration, day 30.10.10.90.00.0-0.00.10.1-0.30.20.4-1.0
Locomotion velocity, session 70.70.81.31.11.11.11.11.1-0.10.90.20.4
Locomotion distance, session 72.22.74.22.12.12.01.91.90.31.90.21.0
Stereotopy head waving bouts, day 70.40.40.8-0.8-0.9-0.9-0.7-0.7-0.3-0.6-0.2-0.3
Stereotopy head waving duration, day 70.50.61.0-1.0-1.0-1.0-0.9-0.9-0.3-0.8-0.4-0.4
Locomotion velocity, session 80.10.10.40.40.40.40.20.2-0.20.4-0.70.1
Locomotion distance, session 81.01.55.4-0.9-0.9-0.9-1.0-1.00.1-0.7-2.31.8
Degree of sensitization distance1.51.53.6-0.8-0.8-0.8-1.0-1.01.7-1.0-1.51.9
Degree of sensitization stereotypy0.40.50.7-0.9-0.9-0.9-0.7-0.7-0.5-0.6-0.3-0.2
Conditioned locomotion4.65.46.9-2.6-2.6-2.6-2.6-2.61.3-2.4-2.31.5
Cocaine response after cond. corrected0.50.50.60.80.80.80.70.7-0.70.50.8-0.6
Cocaine response after cond. not corrected1.01.11.41.21.21.21.21.2-0.71.10.9-0.7
Cocaine response before conditioning0.40.41.30.70.70.70.70.70.21.1-0.00.1
Saline control response2.02.63.7-1.7-1.7-1.7-1.9-1.91.1-1.7-1.40.7
Bone: connectivity density0.30.52.0-0.3-0.2-0.2-0.4-0.40.8-0.6-1.41.1
Bone: cortical apparent density2.43.24.32.12.12.12.02.0-0.41.91.7-1.1
Bone: cortical area5.78.616.8-3.2-3.2-3.2-3.2-3.2-4.1-2.30.1-2.1
Bone: cortical porosity1.01.13.4-0.3-0.4-0.4-0.1-0.1-1.9-0.21.8-1.6
Bone: cortical porosity0.80.92.3-0.7-0.7-0.7-0.5-0.5-1.5-0.51.3-1.2
Bone: cortical thickness6.510.733.0-2.9-2.9-2.9-3.0-3.0-5.7-2.01.8-3.5
Bone: cortical thickness3.23.712.5-1.5-1.5-1.5-1.5-1.5-3.5-0.81.6-2.4
Bone: cortical tissue density2.73.65.02.22.22.22.22.2-0.22.01.7-1.1
Condit. Reinf. active minus inactive responses1.92.23.3-1.7-1.7-1.7-1.7-1.70.1-1.8-1.30.4
Condit. Reinf. active-inactive response ratio0.70.81.2-1.0-1.0-1.0-1.0-1.0-0.2-1.1-0.90.0
Condit. Reinf. active responses3.64.46.5-2.4-2.4-2.4-2.4-2.40.5-2.6-1.90.9
Condit. Reinf. inactive responses1.01.21.8-1.2-1.2-1.2-1.1-1.10.8-1.3-1.00.8
Incentive salience index mean1.61.92.8-1.5-1.5-1.5-1.5-1.50.5-1.7-1.60.7
Condit. Reinf. lever presses0.20.30.90.00.00.00.10.10.9-0.0-0.91.0
Condit. Reinf. active minus inactive responses1.31.62.4-1.5-1.4-1.4-1.6-1.6-0.7-1.3-1.0-0.1
Condit. Reinf. active-inactive response ratio2.72.84.1-2.0-2.0-2.0-2.0-2.0-1.0-1.9-0.6-0.5
Condit. Reinf. active responses0.30.51.0-0.7-0.7-0.7-0.8-0.8-0.2-0.7-1.00.1
Condit. Reinf. inactive responses0.50.61.01.01.00.90.90.90.10.9-0.2-0.1
Condit. Reinf. lever presses0.30.40.8-0.5-0.5-0.5-0.6-0.60.3-0.6-0.90.8
Condit. Reinf. lever reinforcers received0.40.51.3-0.7-0.7-0.7-0.8-0.8-0.0-0.7-1.10.4
Conditioned reinforcement - actives0.20.20.7-0.1-0.3-0.3-0.4-0.40.7-0.1-0.50.8
Conditioned reinforcement - inactives0.10.10.3-0.3-0.3-0.3-0.3-0.3-0.0-0.50.10.3
Conditioned locomotion0.10.10.20.40.20.2-0.3-0.30.50.0-0.30.5
Patch foraging indifference point 0 sec0.00.10.40.20.20.20.20.20.6-0.1-0.30.1
Patch foraging indifference point AUC0.10.20.2-0.4-0.4-0.3-0.5-0.5-0.4-0.5-0.30.1
Delay disc. indifference point, 0s delay0.20.20.8-0.2-0.3-0.30.00.0-0.80.30.3-0.9
Delay disc. indifference point, 16s delay1.11.12.31.21.01.11.51.50.61.1-0.30.6
Delay disc. indifference point, 2s delay0.50.60.80.90.70.80.70.7-0.50.80.6-0.7
Delay disc. indifference point, 24s delay5.14.97.52.72.52.72.62.6-1.02.11.7-1.0
Delay disc. indifference point, 4s delay0.40.40.80.80.90.90.50.5-0.40.70.4-0.6
Delay disc. indifference point, 8s delay1.21.21.61.21.11.21.31.3-0.80.91.0-1.0
Indifference point function ln k0.50.81.80.90.90.90.90.9-0.61.30.7-0.4
Indifference point function log k0.50.81.80.90.90.90.90.9-0.61.30.7-0.4
Patch foraging total patch changes 0 sec0.00.10.30.20.20.10.10.10.6-0.1-0.30.0
Patch foraging total patch changes 12 sec0.00.00.10.20.20.20.10.10.4-0.10.3-0.1
Patch foraging total patch changes 18 sec0.10.10.50.30.30.30.20.20.40.1-0.70.3
Patch foraging total patch changes 24 sec0.10.10.3-0.3-0.3-0.2-0.4-0.40.0-0.5-0.5-0.2
Patch foraging total patch changes 6 sec0.20.30.7-0.6-0.6-0.5-0.6-0.60.2-0.9-0.2-0.1
Patch foraging time to switch 0 sec0.40.61.40.80.80.60.90.91.20.70.20.2
Patch foraging water rate 0 sec0.50.81.1-0.9-0.9-0.9-1.0-1.0-0.7-1.0-0.80.3
Patch foraging water rate 12 sec0.30.43.0-0.2-0.3-0.3-0.3-0.3-1.7-0.00.2-0.7
Patch foraging water rate 18 sec0.50.61.0-0.8-0.8-0.8-1.0-1.0-0.7-0.5-0.90.3
Patch foraging water rate 24 sec0.71.01.7-1.0-1.0-1.1-1.1-1.1-0.6-1.0-1.30.1
Patch foraging water rate 6 sec0.60.84.50.40.40.20.40.4-2.10.60.7-1.3
Seeking ratio, delayed vs. immediate footshock1.21.42.6-1.2-1.1-1.0-1.6-1.60.4-1.4-0.90.7
Distance traveled before self-admin0.20.20.5-0.4-0.3-0.2-0.5-0.5-0.7-0.60.5-0.5
Distance traveled after self-admin1.11.24.8-0.4-0.3-0.3-0.6-0.62.2-0.7-1.31.6
Extensor digitorum longus weight0.41.74.2-1.1-1.1-1.1-1.0-1.01.3-0.7-1.92.1
Bone: elastic displacement1.11.22.0-1.3-1.3-1.3-1.4-1.4-0.5-1.10.2-0.4
Bone: elastic work5.36.89.0-2.9-2.9-3.0-3.0-3.0-2.7-2.60.9-1.7
Bone: endosteal estimation0.51.04.1-0.2-0.2-0.20.10.11.6-0.1-2.01.5
Bone: endosteal perimeter0.71.43.2-1.1-1.1-1.2-1.0-1.00.9-1.2-1.80.9
Epididymis fat weight0.51.11.8-1.3-1.3-1.3-1.1-1.10.5-1.0-0.80.7
Delta time in closed arm before/after self-admin0.10.10.4-0.2-0.3-0.20.20.20.40.2-0.40.6
Delta time in open arm before/after self-admin0.30.30.60.70.80.80.40.40.20.60.4-0.1
Diff in mean of infusions in LGA sessions1.31.52.91.51.71.61.31.30.31.30.60.1
Delay discount exponential model param2.42.54.3-2.1-1.9-2.1-1.8-1.80.5-1.5-1.00.7
Extinction: sum of active levers before priming2.82.84.51.61.61.61.61.6-1.81.32.1-1.8
Active lever presses in extinction session 65.35.16.62.52.62.42.12.1-2.41.82.3-2.2
Bone: final force4.37.013.3-2.9-2.9-3.0-2.9-2.9-3.6-2.10.1-1.5
Bone: final moment4.97.913.7-3.1-3.2-3.2-3.1-3.1-3.7-2.40.1-1.6
Food consumed during 24 hour testing period0.60.81.2-0.7-0.7-0.7-0.7-0.70.8-1.1-1.11.0
Glucose5.58.216.02.32.32.22.52.5-3.02.43.8-4.0
Heart weight1.52.13.8-1.6-1.6-1.6-1.5-1.5-1.9-1.00.5-1.3
Delay discount hyperbolic model param2.22.34.0-2.0-1.8-2.0-1.7-1.70.5-1.5-0.90.7
Intermittent access intake day 1-15 change0.40.41.70.0-0.1-0.1-0.0-0.01.3-0.5-0.70.8
Intermittent access intake escalation0.60.62.70.20.10.10.00.01.6-0.5-0.91.3
Intermittent access intake escalation 20.00.00.20.20.10.1-0.0-0.00.2-0.40.20.0
Intermitt. access day 1 inactive lever presses0.00.00.1-0.1-0.1-0.1-0.2-0.2-0.1-0.20.0-0.0
Intermitt. access day 15 inactive lever presses0.60.71.3-0.7-0.7-0.7-0.8-0.80.5-0.9-1.11.1
Intermitt. access escalation Index2.11.93.6-1.0-1.1-1.1-1.0-1.01.7-1.4-1.91.7
Intermittent access day 1 total infusions0.70.81.2-0.8-1.0-1.0-1.1-1.10.1-1.0-0.60.9
Intermittent access day 15 total infusions0.70.82.5-0.3-0.5-0.5-0.7-0.71.1-1.0-1.01.6
Intermittent access terminal intake (last 3 days)0.80.81.9-0.4-0.5-0.5-0.7-0.71.2-1.1-0.91.4
Intermittent access total infusions0.80.92.0-0.6-0.7-0.7-1.0-1.00.8-1.0-0.91.4
Intermittent access day 1 locomotion0.10.10.70.20.10.1-0.3-0.3-0.0-0.0-0.20.8
Intermittent access day 15 total locomotion0.10.20.3-0.0-0.2-0.2-0.6-0.60.3-0.3-0.50.6
Intermittent access total locomotion0.10.10.30.30.10.1-0.3-0.30.00.0-0.30.6
Intermittent access standard deviation2.52.74.21.71.51.51.81.8-1.21.62.0-1.2
Left kidney weight0.61.77.9-0.7-0.7-0.7-0.4-0.4-2.8-0.20.8-2.1
Right kidney weight0.51.56.7-0.5-0.6-0.6-0.3-0.3-2.60.00.8-2.2
Cocaine induced anxiety1.11.34.3-0.6-0.7-0.7-0.5-0.5-2.1-1.11.4-1.5
Post-drug Anxiety0.70.82.50.50.40.40.50.5-1.60.31.4-1.1
Baseline Anxiety2.52.76.11.91.91.91.91.90.22.50.3-0.2
Tail length4.714.319.2-3.9-3.9-3.9-3.8-3.83.2-3.9-4.43.2
Length with tail1.24.57.1-2.7-2.7-2.7-2.4-2.4-0.5-2.3-1.2-0.0
Length without tail2.55.617.71.01.01.01.11.1-4.21.33.3-3.8
Times rat made contact with spout1.31.53.6-1.3-1.3-1.2-1.1-1.11.3-1.9-0.50.5
Lifetime Intake0.30.41.7-0.1-0.3-0.3-0.4-0.40.7-0.5-0.41.3
Liver weight, left0.71.13.60.50.40.50.60.6-1.20.71.7-1.9
Liver weight, right0.71.11.8-1.3-1.3-1.3-1.3-1.3-0.1-1.1-0.20.1
Locomotor activity0.81.22.71.31.21.11.21.20.11.61.0-0.2
Locomotor testing distance0.60.92.61.11.11.01.11.10.61.60.10.2
Locomotor testing rearing0.81.22.21.21.31.11.01.01.51.1-0.11.0
Locomotion in novel chamber0.10.10.30.0-0.0-0.00.40.4-0.10.6-0.40.1
Locomotion in novel chamber post-restriction2.53.04.1-2.0-2.0-1.9-1.8-1.80.8-1.8-1.61.7
Fecal boli incidents, locomotor time 10.20.20.50.50.60.50.20.20.10.50.20.7
Change in fecal boli incidents, locomotor task3.23.04.42.12.02.02.02.0-0.61.61.9-0.8
Time >=10cm from walls, locomotor time 11.61.64.6-0.5-0.7-0.6-0.6-0.61.9-1.1-2.11.8
Bouts of movement, locomotor time 10.60.61.00.70.90.80.80.8-0.71.01.0-0.4
Total resting periods, locomotor time 10.91.01.40.91.11.11.01.0-0.71.11.2-0.5
Rest time, locomotor task time 10.10.10.50.10.10.10.30.3-0.40.30.7-0.2
Distance moved, locomotor task time 10.30.30.40.60.60.70.60.60.60.1-0.60.3
Vertical activity count, locomotor time 10.30.31.2-0.4-0.4-0.3-0.3-0.30.8-0.3-1.10.6
Time >=10cm from walls, locomotor time 20.91.01.7-1.0-1.1-1.1-1.3-1.3-0.5-1.0-0.6-0.4
Bouts of movement, locomotor time 20.90.91.61.11.11.21.21.2-0.11.20.2-0.1
Total resting periods, locomotor time 20.40.50.80.70.70.80.90.90.30.9-0.20.4
Rest time, locomotor task time 20.40.42.00.0-0.00.00.00.01.2-0.2-0.51.4
Distance moved, locomotor task time 20.30.31.50.10.00.10.20.2-1.00.10.6-1.2
Vertical activity count, locomotor time 20.20.20.8-0.4-0.4-0.4-0.2-0.2-0.90.1-0.1-0.9
Light reinforcement 11.32.43.4-1.6-1.6-1.4-1.6-1.61.8-1.3-1.71.2
Light reinforcement 21.31.72.5-1.6-1.6-1.5-1.6-1.60.5-1.3-1.10.7
Bone: marrow area0.40.93.9-0.2-0.1-0.20.20.21.5-0.0-2.01.4
Bone: maximum diameter1.12.13.1-1.7-1.7-1.7-1.6-1.6-1.8-1.1-0.7-0.6
Bone: maximum force4.68.011.9-3.3-3.3-3.3-3.2-3.2-3.4-2.4-0.3-1.2
Bone: maximum moment5.29.012.9-3.5-3.5-3.6-3.4-3.4-3.5-2.7-0.3-1.3
Mean time between licks in bursts1.52.23.41.81.81.71.81.80.11.70.6-0.4
Mean num. licks in bursts0.20.20.8-0.3-0.2-0.2-0.2-0.20.9-0.6-0.0-0.5
Cd content in liver1.51.72.21.51.41.51.41.4-1.01.31.0-0.8
Co content in liver0.30.30.60.70.70.70.80.80.00.5-0.50.2
Cu content in liver0.20.31.20.10.10.0-0.2-0.2-0.8-0.11.1-0.9
Fe content in liver1.41.62.61.61.61.61.51.50.81.4-0.20.4
K content in liver1.81.83.8-1.1-1.1-1.1-1.3-1.30.3-1.4-1.71.9
Mg content in liver1.01.04.5-0.2-0.2-0.2-0.4-0.41.1-0.5-1.72.1
Mn content in liver0.40.52.3-0.5-0.5-0.5-0.5-0.5-1.5-0.40.4-0.3
Na content in liver0.10.10.20.40.40.50.40.40.00.2-0.10.3
Rb content in liver1.11.42.4-1.2-1.2-1.3-1.6-1.60.0-1.2-1.00.6
Se content in liver0.50.72.4-0.5-0.4-0.4-0.5-0.51.5-0.9-0.71.1
Sr content in liver0.50.41.40.20.20.20.30.3-1.10.11.1-1.2
Zn content in liver0.10.10.20.40.40.40.40.4-0.00.3-0.30.2
Bone: minimum diameter2.13.95.8-2.4-2.4-2.4-2.3-2.3-1.3-2.0-1.0-0.3
Time in familiar zone, hab. session 10.30.31.10.00.00.00.20.2-0.90.01.0-1.1
Time in novel zone, hab. session 10.10.10.70.00.00.0-0.2-0.20.8-0.0-0.30.6
Total zone transitions, hab. session 10.10.20.50.20.20.20.30.3-0.70.50.5-0.5
Total locomotion distance, hab. session 10.30.40.8-0.9-0.9-0.9-0.8-0.80.1-0.5-0.40.2
Locomotion velocity, hab. session 10.40.60.9-1.0-1.0-1.0-0.9-0.90.0-0.5-0.60.3
Time in familiar zone, hab. session 20.30.30.40.70.70.60.60.60.60.5-0.10.3
Time in novel zone, hab. session 20.10.10.5-0.1-0.1-0.0-0.1-0.1-0.70.10.4-0.5
Total zone transitions, hab. session 20.30.41.3-0.6-0.7-0.6-0.6-0.6-0.2-0.3-1.20.6
Total locomotion distance, hab. session 21.62.23.6-1.6-1.6-1.6-1.5-1.50.8-1.1-1.91.5
Locomotion velocity, hab. session 21.92.63.8-1.8-1.8-1.8-1.7-1.70.6-1.3-1.91.4
Novel to familiar place preference ratio1.71.82.4-1.5-1.5-1.5-1.5-1.5-1.2-1.50.4-0.8
Novelty place preference1.71.82.3-1.5-1.5-1.5-1.5-1.5-1.3-1.50.4-0.8
Time in novel zone, NPP test1.41.51.9-1.4-1.4-1.4-1.3-1.3-1.1-1.40.4-0.8
Total zone transitions, NPP test0.50.72.6-0.0-0.00.0-0.1-0.11.10.3-1.61.5
Total locomotion distance, NPP test1.11.53.8-0.8-0.8-0.8-0.8-0.81.8-0.4-1.91.8
Locomotion velocity, NPP test1.01.53.4-0.9-0.9-0.9-0.9-0.91.4-0.6-1.81.7
Intraocular pressure0.91.32.6-1.1-1.1-1.1-1.1-1.11.1-1.0-1.60.9
Delta distance traveled before/after self-admin1.01.14.50.80.80.80.40.42.10.4-0.91.4
Delta ambulatory time before/after self-admin1.71.95.31.51.41.40.80.82.30.9-0.81.5
Parametrial fat weight1.12.23.3-1.8-1.8-1.8-1.6-1.60.7-1.8-0.70.7
Pavlov. Cond. lever latency0.50.60.90.80.80.80.80.80.00.9-0.80.9
Pavlov. Cond. magazine entry latency0.81.01.7-1.1-1.1-1.1-1.0-1.0-0.3-1.30.3-1.1
Pavlov. Cond. change in total contacts0.50.52.6-0.1-0.1-0.10.10.1-0.5-0.01.3-1.6
Pavlov. Cond. index score1.51.83.1-1.7-1.7-1.7-1.6-1.60.0-1.8-0.1-0.5
Pavlov. Cond. latency score1.11.42.5-1.4-1.4-1.4-1.3-1.30.1-1.60.1-0.6
Pavlov. Cond. lever contacts0.30.40.6-0.7-0.7-0.7-0.6-0.60.5-0.80.2-0.3
Pavlov. Cond. magazine entry number0.91.12.91.01.01.00.90.90.61.1-0.91.7
Pavlov. Cond. intertrial magazine entries0.70.91.7-0.8-0.8-0.8-0.8-0.80.6-0.9-1.31.3
Pavlov. Cond. lever-magazine prob. diff.1.41.82.9-1.6-1.6-1.6-1.5-1.5-0.3-1.7-0.1-0.8
Pavlov. Cond. response bias0.70.81.7-0.9-0.9-0.9-0.8-0.8-0.4-1.00.7-1.3
Pavlov. Cond. lever latency0.91.22.31.01.01.01.01.0-0.81.01.5-1.3
Pavlov. Cond. magazine entry latency1.31.52.41.31.31.31.41.41.01.6-0.01.1
Pavlov. Cond. change in total contacts0.20.30.90.30.30.30.30.30.70.3-0.80.9
Pavlov. Cond. index score0.20.31.30.20.20.20.30.30.90.3-0.71.1
Pavlov. Cond. latency score0.30.31.40.00.00.00.20.21.00.2-0.91.2
Pavlov. Cond. lever contacts1.52.03.7-1.3-1.3-1.3-1.3-1.31.1-1.3-1.91.8
Pavlov. Cond. magazine entry number1.21.52.0-1.3-1.3-1.2-1.3-1.3-1.2-1.40.1-1.3
Pavlov. Cond. intertrial magazine entries1.82.33.4-1.8-1.8-1.8-1.8-1.8-0.1-1.8-1.20.2
Pavlov. Cond. lever-magazine prob. diff.0.30.41.50.40.40.30.50.51.00.4-0.61.2
Pavlov. Cond. response bias0.30.52.2-0.2-0.2-0.2-0.2-0.20.9-0.1-0.91.5
Time in closed arm before self-admin0.50.61.50.80.70.70.30.3-1.20.31.0-0.8
Time in closed arm after self-admin1.41.52.61.31.21.11.31.3-1.21.21.6-0.6
Time in open arm before self-admin0.40.50.7-0.8-0.9-0.8-0.6-0.60.5-0.5-0.80.6
Time in open arm after self-admin0.00.00.10.20.20.3-0.0-0.0-0.10.2-0.2-0.1
Bone: periosteal estimation1.53.14.7-2.2-2.2-2.2-2.0-2.0-1.5-1.5-1.3-0.2
Bone: periosteal perimeter2.13.65.3-2.1-2.1-2.2-2.0-2.0-2.3-1.8-0.2-1.3
Bone: post-yield work0.10.10.6-0.1-0.1-0.10.10.1-0.0-0.0-0.80.3
Progressive ratio test 1 active lever presses0.90.92.3-0.4-0.5-0.5-0.9-0.91.1-0.8-1.41.5
Progressive ratio test 1 breakpoint1.41.42.6-0.8-0.9-0.9-1.3-1.31.2-1.1-1.61.5
Progressive ratio test 1 inactive lever presses0.90.91.8-0.7-0.7-0.7-1.2-1.20.3-1.3-0.91.2
Progressive ratio test 2 active lever presses0.50.51.5-0.5-0.6-0.6-0.6-0.60.7-0.4-0.71.2
Progressive ratio test 2 breakpoint0.80.92.3-0.7-0.8-0.8-0.8-0.81.0-0.6-1.01.5
Progressive ratio test 2 inactive lever presses0.00.00.10.0-0.1-0.1-0.2-0.2-0.1-0.3-0.20.3
Incentive Sensitization - Responses0.90.91.3-1.0-1.1-1.1-0.9-0.90.8-0.7-0.61.1
Incentive Sensitization - Breakpoint0.70.71.0-0.9-1.0-1.0-0.8-0.80.7-0.7-0.61.0
Sum of active levers in priming session hrs 5-60.30.31.10.30.20.10.60.6-0.5-0.11.0-0.5
Progressive ratio0.40.50.90.90.80.90.90.9-0.30.40.1-0.5
Food seeking constrained by brief footshock0.20.20.50.60.70.60.50.50.10.30.40.3
Seeking ratio, punishment vs. effort0.30.40.6-0.5-0.5-0.6-0.7-0.70.7-0.4-0.40.8
Retroperitoneal fat weight3.210.714.0-3.7-3.7-3.6-3.7-3.71.8-3.5-2.72.1
Reaction time number correct0.91.35.7-0.4-0.4-0.5-0.5-0.51.2-0.3-2.41.9
Reaction time mean minus median0.40.61.20.90.90.80.70.70.30.81.10.1
Reaction time mean minus median AUC0.10.10.30.30.30.20.20.20.50.30.60.4
Reaction time num false alarms0.00.10.20.20.20.10.30.3-0.20.0-0.3-0.4
Reaction time num false alarms AUC0.10.20.40.50.50.40.60.60.10.4-0.2-0.3
Reaction time trials correct on left0.91.35.7-0.4-0.4-0.5-0.5-0.51.2-0.3-2.41.9
Reaction time trials on left1.01.45.8-0.4-0.4-0.5-0.5-0.51.2-0.2-2.42.0
Reaction time mean0.20.30.6-0.6-0.6-0.6-0.5-0.50.4-0.6-0.20.8
Reaction time mean AUC0.40.61.4-0.7-0.7-0.8-0.6-0.60.7-0.6-0.51.2
Median of all reaction times0.30.40.6-0.7-0.8-0.8-0.6-0.60.2-0.7-0.30.7
Reaction time omissions0.40.52.50.30.30.10.10.11.20.2-0.61.6
Reaction time false alarm rate0.40.61.50.60.60.60.80.8-0.50.41.0-1.2
Reaction time premature initiation rate0.50.61.10.90.90.91.01.0-0.11.00.4-0.3
Reaction time premature initiations0.30.41.00.50.50.40.50.50.60.8-1.00.9
Std. dev. reaction times0.20.30.40.60.60.50.60.60.50.70.40.7
Reaction time trials completed1.01.45.8-0.4-0.4-0.5-0.5-0.51.2-0.2-2.42.0
Reaction time trials AUC1.01.46.0-0.5-0.5-0.6-0.6-0.61.1-0.4-2.51.9
Run reversals in cocaine runway, females0.30.30.80.20.30.20.30.30.70.4-0.80.9
Run reversals in cocaine runway, males0.50.50.9-0.7-0.7-0.7-1.0-1.0-0.1-0.60.5-0.6
Latency to leave start box in cocaine runway0.20.20.70.60.40.50.10.10.90.1-0.30.6
Latency to leave start box in cocaine runway, F0.30.31.00.20.00.2-0.5-0.51.0-0.2-1.00.9
Latency to leave start box in cocaine runway, M0.10.10.40.20.20.10.30.30.60.10.20.3
Std. dev. time between licks in bursts1.11.34.0-0.7-0.7-0.8-0.8-0.81.3-0.4-2.01.8
Total sessions with >9 infusions0.20.20.50.60.50.50.40.40.00.4-0.10.7
Short access day 1 total inactive lever presses0.20.21.0-0.0-0.1-0.10.10.10.50.1-0.71.0
Short access day 10 total inactive lever presses1.01.12.2-1.5-1.5-1.5-1.1-1.1-0.4-1.0-0.30.2
Short access day 1 total infusions1.71.82.91.71.41.41.71.7-0.51.51.1-0.0
Short access day 10 total infusions0.40.42.2-0.1-0.2-0.2-0.3-0.30.7-0.6-0.41.5
Short access total infusions0.10.11.00.30.10.10.10.10.4-0.00.21.0
Short access day 1 locomotion0.80.81.30.90.70.71.01.0-1.10.81.1-0.7
Short access day 10 total locomotion0.91.02.51.21.01.00.60.6-1.01.01.6-0.5
Short access total locomotion0.80.81.41.11.01.00.60.6-1.01.01.2-0.4
One hour access (0.3 mA shock)1.82.22.8-1.4-1.7-1.7-1.5-1.51.2-1.5-1.21.5
Compulsive drug intake0.80.81.6-1.2-1.2-1.2-1.0-1.0-0.1-0.7-0.10.1
One hour access (shock baseline)1.01.12.3-0.7-0.8-0.8-0.9-0.91.3-1.0-1.31.5
Social response proportion1.41.52.41.51.51.41.51.5-0.51.40.5-0.2
Social responses0.40.51.40.80.80.80.80.8-0.21.20.2-0.2
Social time0.10.20.40.30.30.20.40.4-0.50.60.3-0.5
Soleus weight1.54.45.9-2.4-2.4-2.4-2.4-2.40.8-2.3-1.71.4
Bone: stiffness1.32.08.8-1.2-1.3-1.3-1.0-1.0-3.0-0.30.7-1.4
Tibialis anterior weight0.51.64.0-1.0-1.0-0.9-0.9-0.92.0-0.8-1.41.8
Time to tail flick, vehicle, before self-admin0.40.50.8-0.9-0.8-0.7-0.7-0.70.3-0.6-0.70.4
Time to tail flick, vehicle, after self-admin0.91.01.81.01.11.00.90.9-0.91.30.9-0.9
Time to tail flick, test, before self-admin0.40.31.00.81.01.00.00.00.50.30.30.2
Time to tail flick, test, after self-admin1.51.62.71.71.61.51.21.2-0.51.31.0-0.7
Delta time to tail flick, vehicle, before/after SA0.20.20.40.40.60.50.20.20.40.40.20.4
Delta time to tail flick, test, before/after SA1.81.63.20.90.80.71.21.2-1.81.01.4-1.8
Tibia length7.120.029.5-5.4-5.4-5.4-5.2-5.2-3.9-4.6-0.1-1.9
Ambulatory time before self-admin0.70.71.2-0.9-0.8-0.8-0.9-0.9-1.0-1.10.3-0.4
Ambulatory time after self-admin0.30.31.70.20.10.2-0.3-0.31.3-0.2-0.70.6
Bone: tissue strength1.21.11.6-1.2-1.2-1.2-1.2-1.2-0.7-0.8-1.10.5
Total heroin consumption2.52.98.41.31.41.41.11.1-2.90.61.8-2.6
Bone: trabecular number0.10.10.3-0.2-0.2-0.2-0.3-0.30.0-0.5-0.60.4
Bone: trabecular spacing0.70.92.9-0.3-0.3-0.3-0.3-0.31.6-0.0-1.71.6
Bone: trabecular thickness0.60.72.3-0.4-0.4-0.4-0.2-0.2-1.5-0.61.1-1.3
Bone: trabecular tissue density0.81.11.71.31.31.31.21.20.01.20.90.1
Water consumed over 24 hours0.10.10.30.00.00.10.20.2-0.6-0.30.3-0.4
Number of responses in last shaping day0.20.20.9-0.3-0.4-0.4-0.5-0.5-1.0-0.2-0.1-0.2