Fn3k

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative polyA	NM_001109051.2	0.11	0.06	5.2e-07	0.07	0.07	0.06	0.07	1.8e-07	1.6e-07	4.5e-06	2.9e-07
2	NAcc	mRNA stability	Fn3k	0.02	0.01	4.6e-03	0.01	0.01	0.01	0.01	1.6e-02	4.2e-03	4.3e-03	8.4e-03
3	Brain	gene expression	Fn3k	0.06	0.04	1.5e-03	0.04	0.03	0.04	0.04	5.9e-05	1.2e-03	1.8e-04	9.9e-05
4	Brain	mRNA stability	Fn3k	0.06	0.03	4.4e-08	0.09	0.08	0.07	0.07	1.2e-08	9.2e-08	3.6e-07	1.6e-07
5	PL	mRNA stability	Fn3k	0.11	0.05	2.8e-09	0.09	0.09	0.09	0.09	1.2e-09	3.6e-10	7.2e-10	1.5e-09
6	OFC	gene expression	Fn3k	0.37	0.15	8.4e-04	0.07	0.01	-0.01	0.07	8.7e-03	1.6e-01	4.9e-01	1.1e-02
7	PL	gene expression	Fn3k	0.03	0.02	7.2e-03	0.01	0.02	0.01	0.01	3.9e-02	6.4e-03	2.4e-02	3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.3	0.6	1.1	1.0	0.8	0.8	-0.7	1.0	0.6	-0.5
Area under the delay curve	0.7	1.1	3.2	-0.8	-1.4	-0.2	1.8	-1.2	-0.2	-0.0
BMI with tail	0.8	2.8	6.1	1.9	1.6	-2.5	-1.2	1.2	-2.1	0.5
BMI without tail	1.1	5.9	12.0	3.5	3.4	0.0	-2.8	2.9	0.4	-1.3
Body weight	1.5	6.6	12.2	3.5	3.2	-2.3	-2.9	2.4	-2.0	0.4
Weight adjusted by age	0.8	2.3	5.0	1.9	1.9	-0.6	-2.2	1.8	-0.4	0.4
Bone surface	0.3	0.6	1.4	0.6	0.8	1.2	-0.6	0.6	1.0	-0.5
Bone volume	0.3	0.7	1.2	0.7	0.9	1.1	-0.6	0.8	0.9	-0.6
Breakpoint value in progressive ratio session	0.6	1.2	2.1	-0.4	-0.7	-1.3	1.1	-1.5	-1.1	1.0
Number of licking bursts	0.2	0.5	0.8	0.4	0.6	0.9	-0.6	0.6	0.9	-0.9
Context. condit. distance diff. score	2.0	2.4	4.2	1.1	1.5	2.0	-0.9	1.1	1.9	-2.0
Locomotion velocity, session 1	2.8	3.2	4.0	-2.0	-2.0	-1.7	1.5	-1.5	-1.8	1.9
Locomotion distance, session 1	0.4	0.5	1.0	-0.7	-0.7	-0.7	1.0	-0.8	-0.6	-0.4
Locomotion velocity, session 2	2.7	3.2	5.7	-2.1	-2.3	-0.8	2.4	-2.2	-0.9	0.6
Locomotion distance, session 2	0.1	0.2	0.4	0.6	0.3	-0.5	0.0	0.2	-0.3	-0.6
Locomotion velocity, session 3	2.2	2.6	4.5	-1.4	-2.1	-1.3	1.9	-1.6	-1.4	1.2
Locomotion distance, session 3	2.6	3.0	5.4	-1.7	-2.3	-1.1	2.3	-2.1	-1.2	0.7
Stereotopy head waving bouts, day 3	0.6	0.8	1.6	-0.7	-0.7	-1.2	0.4	-0.5	-1.2	1.0
Stereotopy head waving duration, day 3	0.3	0.3	0.9	-0.4	-0.3	-0.9	0.2	-0.3	-1.0	0.5
Locomotion velocity, session 7	0.7	0.7	1.0	-0.9	-0.9	0.9	1.0	-0.9	0.7	-0.5
Locomotion distance, session 7	1.5	1.9	3.6	-1.4	-1.3	1.2	1.9	-1.4	1.0	-1.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	0.6	0.9	-0.4	-0.8	0.5	-0.2	-0.0
Stereotopy head waving duration, day 7	0.3	0.4	0.8	0.8	0.9	-0.1	-0.9	0.7	-0.1	-0.0
Locomotion velocity, session 8	0.2	0.2	0.7	0.8	0.1	-0.3	0.2	0.4	-0.2	-0.5
Locomotion distance, session 8	2.0	2.9	6.8	1.8	1.9	1.4	-1.0	1.3	1.5	-2.6
Degree of sensitization distance	1.7	1.8	3.7	0.8	1.2	1.9	-0.9	1.1	1.8	-1.3
Degree of sensitization stereotypy	0.4	0.4	1.0	0.8	1.0	-0.1	-0.8	0.6	0.0	-0.3
Conditioned locomotion	4.0	4.7	7.4	2.7	2.7	1.4	-2.5	2.6	1.3	-1.4
Cocaine response after cond. corrected	0.5	0.7	1.0	-0.6	-1.0	-0.8	0.8	-0.7	-0.9	1.0
Cocaine response after cond. not corrected	0.7	1.1	1.6	-1.0	-1.3	-0.7	1.3	-1.2	-0.8	0.7
Cocaine response before conditioning	0.4	0.5	1.1	-0.6	-0.4	0.6	0.7	-0.8	0.6	-1.0
Saline control response	1.9	2.6	4.8	2.1	1.5	1.2	-1.8	2.2	1.2	-0.6
Bone: connectivity density	0.6	1.0	2.3	0.8	0.6	1.5	-0.4	0.9	1.3	-1.1
Bone: cortical apparent density	1.6	2.6	5.3	-2.1	-2.3	-0.4	2.1	-1.8	-0.5	0.6
Bone: cortical area	6.3	10.2	16.6	4.1	3.0	-3.8	-3.1	2.9	-3.3	1.6
Bone: cortical porosity	1.5	1.7	4.3	-0.6	-0.2	-2.1	-0.4	-0.7	-1.9	1.7
Bone: cortical porosity	1.1	1.2	3.1	-0.0	0.2	-1.8	-0.7	-0.1	-1.6	1.5
Bone: cortical thickness	8.5	14.2	29.8	3.8	2.3	-5.5	-3.0	2.8	-4.9	3.0
Bone: cortical thickness	3.2	4.0	9.7	1.7	1.0	-3.1	-1.4	1.3	-2.7	1.8
Bone: cortical tissue density	1.9	3.0	6.1	-2.3	-2.5	-0.2	2.2	-1.9	-0.4	0.6
Condit. Reinf. active minus inactive responses	1.8	2.0	4.2	2.0	1.8	-0.2	-1.8	1.9	-0.0	-0.1
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.0	1.7	1.0	-0.6	-1.2	1.4	-0.4	0.4
Condit. Reinf. active responses	2.8	3.6	6.7	2.5	2.6	0.2	-2.4	2.4	0.4	-0.6
Condit. Reinf. inactive responses	0.7	0.9	1.8	0.8	1.3	0.7	-1.1	1.0	0.7	-0.7
Incentive salience index mean	1.3	1.6	3.1	1.8	1.7	0.2	-1.5	1.6	0.4	-0.5
Condit. Reinf. lever presses	0.3	0.5	1.2	-0.0	0.4	0.9	0.1	0.0	1.0	-1.1
Condit. Reinf. active minus inactive responses	1.1	1.8	4.0	2.0	1.3	-1.1	-1.4	1.5	-1.0	0.3
Condit. Reinf. active-inactive response ratio	1.6	2.6	3.9	1.9	1.7	-1.3	-2.0	1.8	-1.2	0.9
Condit. Reinf. active responses	0.4	0.6	2.1	1.4	0.7	-0.5	-0.6	0.9	-0.5	-0.1
Condit. Reinf. inactive responses	0.3	0.4	1.2	-0.2	-0.8	0.2	1.1	-0.7	0.1	-0.4
Condit. Reinf. lever presses	0.4	0.6	1.1	1.0	0.8	0.4	-0.6	0.8	0.6	-0.8
Condit. Reinf. lever reinforcers received	0.4	0.6	2.0	1.4	0.9	-0.3	-0.6	0.8	-0.2	-0.4
Conditioned reinforcement - actives	0.0	0.2	0.4	-0.4	-0.2	0.2	0.6	-0.5	-0.0	-0.6
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	0.0	-0.0	0.2	-0.2	-0.2	-0.1
Conditioned locomotion	0.1	0.2	0.7	0.5	0.2	0.1	0.4	-0.1	0.0	-0.8
Patch foraging indifference point 0 sec	0.0	0.1	0.1	0.3	-0.1	0.4	-0.2	0.3	0.3	-0.1
Patch foraging indifference point AUC	0.1	0.2	0.3	0.1	0.5	0.6	-0.4	0.4	0.4	-0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.8	0.5	0.0	-0.6	-0.2	0.3	-0.9	0.4
Delay disc. indifference point, 16s delay	0.6	0.8	1.6	-0.5	-0.7	0.6	1.3	-1.0	0.7	-1.3
Delay disc. indifference point, 2s delay	0.5	0.5	1.1	-0.7	-0.8	-0.6	1.1	-0.9	-0.5	0.3
Delay disc. indifference point, 24s delay	2.7	4.3	7.9	-2.4	-2.7	-1.1	2.8	-2.6	-0.8	1.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.2	-0.8	-0.3	0.8	0.0	-0.4	0.5
Delay disc. indifference point, 8s delay	0.7	1.2	2.3	-0.9	-1.5	-0.9	1.4	-1.1	-0.9	1.0
Indifference point function ln k	0.1	0.4	0.8	-0.3	-0.9	-0.6	0.8	-0.5	-0.5	0.3
Indifference point function log k	0.1	0.4	0.8	-0.3	-0.9	-0.6	0.8	-0.5	-0.5	0.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.5	0.0	0.3	-0.2	0.4	0.3	-0.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.4	-0.0	0.2	-0.1	-0.1	0.2	0.0
Patch foraging total patch changes 18 sec	0.1	0.2	0.6	0.5	0.2	0.7	-0.0	0.3	0.6	-0.8
Patch foraging total patch changes 24 sec	0.1	0.4	1.1	1.0	0.6	-0.2	-0.7	0.9	-0.1	0.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.8	0.3	0.5	0.0	-0.9	0.6	0.1	0.1
Patch foraging time to switch 0 sec	0.1	0.5	1.4	-1.2	-0.6	0.3	0.8	-1.0	0.3	-0.2
Patch foraging water rate 0 sec	0.3	1.2	4.1	2.0	1.0	0.2	-0.9	1.4	0.2	-0.3
Patch foraging water rate 12 sec	0.2	0.6	1.7	1.3	0.6	-0.9	-0.4	0.8	-0.8	-0.0
Patch foraging water rate 18 sec	0.5	1.1	3.4	1.8	1.2	-0.4	-0.8	1.3	-0.1	-0.6
Patch foraging water rate 24 sec	1.6	2.3	7.9	2.8	1.7	-0.2	-1.1	1.8	-0.0	-0.8
Patch foraging water rate 6 sec	0.6	0.8	2.5	0.8	-0.1	-1.6	0.3	0.1	-1.5	0.4
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	2.6	1.5	1.2	0.2	-1.5	1.6	0.3	-0.1
Distance traveled before self-admin	0.1	0.3	0.7	0.8	0.1	-0.2	-0.2	0.5	-0.5	0.8
Distance traveled after self-admin	0.7	1.3	4.0	0.4	0.7	2.0	0.1	0.3	1.3	-1.6
Extensor digitorum longus weight	0.4	1.4	3.1	1.1	1.8	0.6	-1.0	1.2	0.7	-1.5
Bone: elastic displacement	1.0	1.2	2.0	1.3	0.9	-1.0	-1.4	1.3	-0.8	0.8
Bone: elastic work	5.5	7.2	9.4	2.7	2.0	-3.0	-3.1	2.6	-2.7	2.6
Bone: endosteal estimation	0.6	1.4	3.5	0.2	0.9	1.6	0.1	-0.3	1.6	-1.9
Bone: endosteal perimeter	0.4	0.9	1.5	1.1	1.2	1.0	-1.0	0.8	0.9	-0.5
Epididymis fat weight	0.4	1.8	4.3	1.7	2.1	0.3	-1.6	1.2	0.3	-1.1
Delta time in closed arm before/after self-admin	0.7	0.7	1.7	-0.1	0.3	1.2	-0.4	0.2	1.3	-1.1
Delta time in open arm before/after self-admin	0.3	0.4	0.8	-0.7	-0.9	-0.2	0.9	-0.7	-0.1	0.2
Diff in mean of infusions in LGA sessions	0.2	0.4	0.7	-0.6	-0.4	0.8	0.6	-0.8	0.9	-0.1
Delay discount exponential model param	1.4	1.9	5.0	1.2	1.9	0.5	-2.2	1.6	0.5	-0.4
Extinction: sum of active levers before priming	1.4	2.1	3.7	-1.2	-1.3	-1.9	1.2	-1.1	-1.7	1.5
Active lever presses in extinction session 6	6.3	6.3	10.4	-1.5	-2.2	-3.2	2.5	-2.4	-3.0	2.5
Bone: final force	5.7	9.3	17.3	4.2	3.3	-3.1	-3.2	3.0	-2.6	1.1
Bone: final moment	6.3	10.2	17.9	4.2	3.4	-3.3	-3.5	3.1	-2.7	1.3
Food consumed during 24 hour testing period	0.3	0.6	1.2	0.5	0.7	1.1	-0.8	0.8	1.0	-0.4
Glucose	10.4	16.5	20.2	-4.3	-4.5	-3.9	3.1	-4.2	-4.1	4.2
Heart weight	1.4	2.3	5.5	1.1	1.2	-2.3	-1.2	0.9	-2.1	1.1
Delay discount hyperbolic model param	1.4	1.7	4.5	1.2	1.8	0.6	-2.1	1.5	0.5	-0.4
Intermittent access intake day 1-15 change	0.1	0.4	1.0	-0.2	-0.6	1.0	0.9	-0.6	0.7	0.0
Intermittent access intake escalation	0.1	0.3	0.8	0.1	-0.7	0.9	0.8	-0.4	0.6	0.1
Intermittent access intake escalation 2	0.1	0.2	0.5	0.1	-0.6	0.3	0.6	-0.4	-0.0	0.7
Intermitt. access day 1 inactive lever presses	0.1	1.9	2.8	1.7	1.6	1.3	-0.8	1.2	1.3	-1.4
Intermitt. access day 15 inactive lever presses	0.3	1.5	2.7	1.6	1.2	1.2	-0.8	1.3	1.2	-1.2
Intermitt. access escalation Index	0.4	1.2	3.3	0.5	0.5	1.8	-0.2	0.9	1.7	-0.9
Intermittent access day 1 total infusions	0.0	0.1	0.4	0.2	0.7	-0.4	-0.5	0.3	-0.1	-0.2
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.5	0.3	0.6	0.0	0.4	0.6	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.7	0.3	0.3	0.8	-0.1	0.3	0.8	-0.2
Intermittent access total infusions	0.1	0.1	0.3	0.3	0.3	0.4	-0.1	0.3	0.5	-0.3
Intermittent access day 1 locomotion	0.1	0.2	0.7	0.1	-0.3	-0.4	0.8	-0.4	-0.1	-0.1
Intermittent access day 15 total locomotion	0.0	0.1	0.5	0.7	0.3	-0.1	0.2	0.3	-0.2	0.0
Intermittent access total locomotion	0.1	0.1	0.5	0.3	-0.1	-0.2	0.7	-0.2	-0.1	-0.0
Intermittent access standard deviation	0.5	2.6	4.1	-1.6	-2.0	-1.2	1.7	-2.0	-1.2	1.4
Left kidney weight	0.3	2.1	6.4	0.5	0.4	-2.5	-0.1	-0.2	-2.5	1.1
Right kidney weight	0.4	2.7	8.6	0.6	0.2	-2.9	-0.1	-0.1	-2.9	1.3
Cocaine induced anxiety	1.2	3.4	8.4	-0.2	-1.1	-2.6	0.3	-0.6	-2.6	2.9
Post-drug Anxiety	3.4	3.9	7.5	-0.8	-1.8	-2.5	1.2	-1.3	-2.5	2.7
Baseline Anxiety	0.4	0.7	1.5	-1.1	-0.9	0.5	1.2	-1.0	0.5	-0.5
Tail length	1.2	6.7	11.4	3.1	3.4	1.8	-3.1	2.8	1.8	-1.4
Length with tail	0.3	1.5	2.9	1.7	1.4	-1.0	-1.3	0.9	-1.1	0.9
Length without tail	1.0	5.0	12.9	-0.1	-0.7	-3.6	0.4	-0.7	-3.6	2.9
Times rat made contact with spout	0.8	0.9	2.3	-0.2	0.5	1.5	-1.3	0.8	1.2	0.2
Lifetime Intake	0.1	0.1	0.1	-0.3	-0.2	0.2	0.3	-0.3	0.4	-0.1
Liver weight, left	1.0	1.8	4.0	-1.7	-1.4	-0.9	1.3	-2.0	-1.0	0.4
Liver weight, right	1.2	2.1	4.6	1.9	2.1	0.7	-1.5	1.5	0.7	-1.1
Locomotor activity	0.5	0.8	1.9	-1.2	-1.0	-0.2	1.2	-1.4	-0.2	-0.1
Locomotor testing distance	0.4	1.0	2.0	-1.3	-1.0	0.3	1.4	-1.4	0.2	-0.6
Locomotor testing rearing	0.3	1.2	1.8	-1.0	-0.8	1.3	1.2	-1.0	1.2	-1.0
Locomotion in novel chamber	0.0	0.0	0.1	-0.0	0.1	0.3	-0.2	0.0	0.2	-0.3
Locomotion in novel chamber post-restriction	0.9	2.7	4.1	1.7	2.0	1.4	-2.0	1.7	1.5	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.3	0.9	-0.5	0.2	0.3	0.4	-0.4	0.7	-0.9
Change in fecal boli incidents, locomotor task	3.2	3.4	6.1	-2.5	-2.4	-0.6	1.9	-2.2	-0.8	1.5
Time >=10cm from walls, locomotor time 1	1.6	1.9	3.1	1.7	1.0	1.8	-0.8	1.4	1.5	-1.4
Bouts of movement, locomotor time 1	0.6	0.8	1.8	-1.4	-1.0	-0.7	0.7	-1.0	-0.7	0.5
Total resting periods, locomotor time 1	0.9	1.0	2.4	-1.5	-1.2	-0.7	0.9	-1.1	-0.7	0.7
Rest time, locomotor task time 1	0.3	0.5	1.5	-1.2	-0.6	-0.1	0.4	-1.0	-0.3	0.4
Distance moved, locomotor task time 1	0.1	0.2	0.6	0.2	-0.4	0.4	0.8	-0.2	0.4	-0.2
Vertical activity count, locomotor time 1	0.1	0.5	1.1	1.0	0.7	0.5	-0.5	0.6	0.6	-0.7
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.7	1.1	0.8	-0.7	-1.1	1.3	-0.5	0.4
Bouts of movement, locomotor time 2	0.2	0.8	1.6	-1.3	-1.0	0.1	1.1	-1.2	-0.0	-0.1
Total resting periods, locomotor time 2	0.1	0.4	0.6	-0.8	-0.4	0.6	0.7	-0.8	0.4	-0.7
Rest time, locomotor task time 2	0.4	0.7	1.8	-0.7	0.2	1.3	-0.1	-0.4	1.2	-0.9
Distance moved, locomotor task time 2	0.3	0.4	1.0	0.2	-0.4	-1.0	0.4	0.1	-1.0	0.7
Vertical activity count, locomotor time 2	0.2	0.4	1.0	0.8	0.5	-1.0	0.0	0.3	-0.8	-0.2
Light reinforcement 1	0.6	2.9	4.0	1.1	1.9	2.0	-1.7	1.9	1.9	-1.4
Light reinforcement 2	0.8	1.7	3.3	1.3	1.8	0.8	-1.6	1.5	0.8	-0.8
Bone: marrow area	0.5	1.3	3.3	0.2	0.9	1.5	0.2	-0.3	1.5	-1.8
Bone: maximum diameter	1.2	2.5	5.1	2.3	1.7	-1.7	-1.5	1.4	-1.4	0.6
Bone: maximum force	4.9	9.7	18.9	4.3	3.6	-3.0	-3.3	3.1	-2.5	0.8
Bone: maximum moment	5.5	10.4	18.8	4.3	3.6	-3.2	-3.6	3.2	-2.6	1.1
Mean time between licks in bursts	0.3	1.5	3.9	-1.4	-1.6	-0.1	2.0	-1.4	-0.0	0.0
Mean num. licks in bursts	0.0	0.1	0.4	-0.2	0.0	0.2	-0.4	0.1	0.0	0.7
Cd content in liver	0.6	0.7	2.0	-0.2	0.2	1.1	0.5	-0.4	1.0	-1.4
Co content in liver	0.1	0.2	0.5	-0.2	-0.1	0.7	0.2	-0.1	0.7	-0.2
Cu content in liver	0.2	0.2	0.7	0.3	0.0	-0.1	-0.6	0.5	-0.1	0.8
Fe content in liver	0.5	0.7	1.0	-0.7	-0.4	0.7	1.0	-1.0	0.8	-0.9
K content in liver	2.6	2.6	5.4	1.2	1.0	2.3	-0.6	1.2	2.3	-1.8
Mg content in liver	3.0	3.3	7.6	0.8	0.8	2.7	-0.3	0.9	2.8	-2.4
Mn content in liver	0.1	0.1	0.2	0.5	0.1	-0.5	-0.3	0.5	-0.3	0.2
Na content in liver	0.4	0.5	1.3	-0.0	-0.3	1.1	0.5	-0.1	1.1	-0.8
Rb content in liver	2.8	3.3	5.7	2.4	2.0	1.3	-1.8	2.2	1.3	-1.3
Se content in liver	0.5	0.6	1.7	0.3	0.3	1.3	-0.3	0.6	1.3	-0.6
Sr content in liver	1.1	1.0	2.4	-0.8	-1.0	-1.2	0.3	-0.5	-1.1	1.5
Zn content in liver	1.4	1.6	2.2	0.9	1.5	1.5	-1.1	1.0	1.5	-1.2
Bone: minimum diameter	1.8	3.5	7.2	2.7	2.2	-1.0	-2.4	2.2	-0.8	0.6
Time in familiar zone, hab. session 1	0.3	0.3	0.7	-0.3	-0.3	-0.8	0.0	-0.2	-0.9	0.8
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.1	0.1	0.5	-0.0	0.3	0.5	-0.4
Total zone transitions, hab. session 1	0.1	0.2	0.7	-0.2	-0.1	-0.8	0.1	-0.2	-0.8	0.0
Total locomotion distance, hab. session 1	0.3	0.5	1.0	0.7	1.0	-0.3	-1.0	0.7	-0.3	-0.5
Locomotion velocity, hab. session 1	0.4	0.5	1.2	0.7	1.1	-0.2	-1.0	0.6	-0.2	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.8	-0.5	0.2	0.8	-0.7	0.2	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.5	0.0	-0.5	-0.2	0.3	-0.5	0.3
Total zone transitions, hab. session 2	0.7	0.9	2.1	0.9	1.2	0.6	-0.7	1.0	0.6	-1.4
Total locomotion distance, hab. session 2	1.8	2.4	4.1	1.5	2.0	1.0	-1.6	1.6	1.0	-1.8
Locomotion velocity, hab. session 2	2.1	2.8	5.0	1.8	2.2	0.9	-1.8	1.9	0.9	-1.7
Novel to familiar place preference ratio	1.2	1.6	2.1	1.3	0.9	-1.3	-1.5	1.3	-1.1	1.4
Novelty place preference	1.3	1.6	2.2	1.3	0.9	-1.3	-1.4	1.3	-1.2	1.5
Time in novel zone, NPP test	1.1	1.4	1.8	1.2	0.9	-1.2	-1.3	1.2	-1.1	1.3
Total zone transitions, NPP test	0.9	1.4	4.4	0.8	0.9	1.3	-0.2	0.6	1.3	-2.1
Total locomotion distance, NPP test	1.7	2.3	5.7	1.2	1.7	1.5	-0.9	1.1	1.5	-2.4
Locomotion velocity, NPP test	1.4	2.0	4.1	1.3	1.7	1.3	-1.0	1.1	1.3	-2.0
Intraocular pressure	0.9	1.5	2.7	1.6	1.6	0.9	-1.2	1.1	0.9	-1.2
Delta distance traveled before/after self-admin	0.8	0.9	1.7	-0.8	-0.2	1.3	0.9	-0.6	1.1	-1.3
Delta ambulatory time before/after self-admin	1.1	1.8	3.5	-1.3	-0.4	1.9	1.3	-0.8	1.5	-1.7
Parametrial fat weight	0.5	1.3	2.3	0.6	1.5	1.1	-1.1	1.0	1.3	-1.2
Pavlov. Cond. lever latency	0.6	0.7	2.3	0.1	0.0	1.1	0.7	-0.3	1.0	-1.5
Pavlov. Cond. magazine entry latency	0.9	1.1	2.5	0.8	0.3	-1.2	-1.0	0.8	-1.2	1.6
Pavlov. Cond. change in total contacts	1.0	1.1	2.4	-0.7	-0.6	-1.4	0.1	-0.5	-1.4	1.5
Pavlov. Cond. index score	0.9	1.2	2.3	1.0	0.9	-0.8	-1.5	1.2	-0.8	1.1
Pavlov. Cond. latency score	0.7	0.9	1.7	0.6	0.7	-0.8	-1.3	0.9	-0.8	1.3
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.1	0.3	-0.5	-0.6	0.3	-0.4	0.7
Pavlov. Cond. magazine entry number	1.3	1.7	4.2	-0.4	-0.2	1.7	1.0	-0.5	1.8	-2.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.6	0.8	1.3	1.1	-0.8	0.9	1.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.0	1.1	0.8	-0.9	-1.4	1.2	-0.9	1.2
Pavlov. Cond. response bias	1.0	1.2	3.1	0.2	0.1	-1.5	-0.7	0.3	-1.5	1.8
Pavlov. Cond. lever latency	1.5	2.1	3.1	-1.5	-1.8	-1.3	1.3	-1.4	-1.3	1.5
Pavlov. Cond. magazine entry latency	1.0	1.4	2.3	-1.2	-0.6	1.1	1.3	-1.3	1.0	-1.5
Pavlov. Cond. change in total contacts	0.1	0.3	1.1	0.3	0.3	0.8	0.3	-0.1	0.7	-1.0
Pavlov. Cond. index score	0.3	0.5	1.6	-0.0	0.4	0.9	0.2	-0.2	0.9	-1.3
Pavlov. Cond. latency score	0.4	0.7	2.1	0.1	0.5	1.1	0.1	-0.1	1.1	-1.5
Pavlov. Cond. lever contacts	1.3	1.9	2.6	1.4	1.6	1.4	-1.1	1.2	1.4	-1.5
Pavlov. Cond. magazine entry number	1.0	1.2	1.8	1.1	0.6	-1.1	-1.3	1.2	-1.0	1.3
Pavlov. Cond. intertrial magazine entries	1.0	2.2	5.1	2.3	1.7	0.0	-1.8	2.0	0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.5	-0.3	0.1	0.9	0.5	-0.5	0.9	-1.2
Pavlov. Cond. response bias	0.4	0.5	1.4	0.3	0.6	0.9	-0.1	0.1	0.9	-1.2
Time in closed arm before self-admin	0.6	1.0	2.1	-0.3	-0.7	-1.5	0.9	-0.4	-1.4	1.3
Time in closed arm after self-admin	0.9	1.0	1.9	-1.3	-1.4	-0.2	1.1	-1.2	-0.0	0.8
Time in open arm before self-admin	1.3	1.6	2.4	0.8	1.4	1.1	-1.6	1.3	1.3	-1.1
Time in open arm after self-admin	0.1	0.1	0.2	0.3	0.3	-0.1	0.1	0.1	0.0	-0.5
Bone: periosteal estimation	1.3	3.0	6.8	2.6	2.4	-1.3	-1.9	1.6	-1.0	-0.0
Bone: periosteal perimeter	2.1	4.1	5.5	2.3	1.7	-2.3	-2.1	1.7	-2.2	1.8
Bone: post-yield work	0.1	0.1	0.3	0.5	0.3	-0.2	0.2	0.1	-0.3	-0.2
Progressive ratio test 1 active lever presses	0.1	0.3	0.7	0.0	-0.3	0.5	0.8	-0.3	0.7	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	0.1	-0.2	0.5	0.7	-0.3	0.8	-0.3
Progressive ratio test 1 inactive lever presses	0.7	2.0	2.9	1.7	1.6	1.3	-0.8	1.4	1.5	-1.3
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	0.3	0.4	0.6	0.1	0.0	0.5	-0.6
Progressive ratio test 2 breakpoint	0.1	0.2	0.3	0.3	0.3	0.6	0.1	-0.0	0.5	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.1	-0.1	-0.3	0.5	-0.3	-0.3	0.3
Incentive Sensitization - Responses	0.2	0.5	0.9	0.5	0.9	0.9	-0.6	0.6	0.7	-0.8
Incentive Sensitization - Breakpoint	0.2	0.4	0.7	0.4	0.8	0.8	-0.5	0.5	0.5	-0.7
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.2	-0.7	-0.5	-0.9	0.5	-0.9	-1.0	1.1
Progressive ratio	0.2	0.5	1.2	-0.6	-0.5	-0.8	0.9	-1.1	-0.1	-0.1
Food seeking constrained by brief footshock	0.5	0.6	1.1	-1.0	-1.1	-0.2	0.8	-0.7	0.4	0.8
Seeking ratio, punishment vs. effort	0.1	0.3	0.8	0.4	0.3	0.8	-0.5	0.9	0.3	-0.0
Retroperitoneal fat weight	1.7	7.8	14.6	3.4	3.8	1.7	-3.0	2.8	1.8	-2.2
Reaction time number correct	0.9	3.2	6.9	1.8	1.6	1.8	-0.5	1.4	2.1	-2.6
Reaction time mean minus median	0.1	0.9	2.1	-1.5	-1.0	-0.2	0.8	-1.4	-0.2	0.4
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.4	-0.3	-0.1	0.2	-0.5	0.0	0.1
Reaction time num false alarms	0.0	0.1	0.3	-0.6	-0.1	0.1	0.2	-0.3	0.0	-0.0
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.8	-0.3	0.2	0.4	-0.6	0.2	-0.3
Reaction time trials correct on left	0.9	3.2	6.9	1.8	1.6	1.8	-0.5	1.4	2.1	-2.6
Reaction time trials on left	1.0	3.3	7.1	1.8	1.6	1.8	-0.5	1.4	2.1	-2.7
Reaction time mean	0.1	0.2	0.5	0.2	0.6	-0.1	-0.7	0.3	0.2	-0.2
Reaction time mean AUC	0.1	0.4	0.8	0.5	0.9	0.1	-0.8	0.5	0.4	-0.7
Median of all reaction times	0.3	0.4	0.9	0.7	1.0	-0.2	-0.9	0.7	0.2	-0.4
Reaction time omissions	0.1	0.2	0.5	0.2	0.1	0.5	0.1	0.1	0.7	-0.6
Reaction time false alarm rate	0.8	1.1	2.6	-1.6	-1.0	-0.6	0.7	-1.2	-0.8	1.1
Reaction time premature initiation rate	0.6	0.9	2.4	-1.6	-1.1	0.0	1.0	-1.2	-0.1	0.0
Reaction time premature initiations	0.3	0.8	2.3	-0.4	-0.0	1.2	0.6	-0.3	1.2	-1.5
Std. dev. reaction times	0.1	0.3	0.9	-1.0	-0.5	-0.1	0.5	-0.9	0.1	-0.2
Reaction time trials completed	1.0	3.3	7.1	1.8	1.6	1.8	-0.5	1.4	2.1	-2.7
Reaction time trials AUC	0.9	3.3	6.8	1.9	1.6	1.8	-0.6	1.5	2.0	-2.6
Run reversals in cocaine runway, females	0.2	0.3	0.7	-0.3	0.1	0.6	0.3	-0.1	0.8	-0.8
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.3	0.5	0.0	-0.6	0.5	-0.6	0.6
Latency to leave start box in cocaine runway	0.3	0.4	1.1	-0.6	0.2	0.6	0.8	-0.6	0.3	-1.1
Latency to leave start box in cocaine runway, F	0.9	1.2	4.2	0.3	1.1	1.2	0.2	0.3	1.1	-2.1
Latency to leave start box in cocaine runway, M	0.5	0.4	0.9	-0.9	-0.6	-0.3	0.6	-0.8	-0.6	0.5
Std. dev. time between licks in bursts	1.2	2.3	4.5	1.8	1.4	1.5	-0.4	1.3	1.6	-2.1
Total sessions with >9 infusions	0.4	0.5	1.0	-0.9	-0.8	-0.3	0.9	-1.0	-0.2	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.6	0.0	0.3	-0.1	0.3	-0.3	-0.2	-0.8
Short access day 10 total inactive lever presses	0.4	2.5	5.5	2.3	1.9	0.8	-1.7	1.9	0.9	-0.8
Short access day 1 total infusions	0.8	1.5	2.6	-1.6	-1.6	-0.6	1.5	-1.4	-0.6	0.5
Short access day 10 total infusions	0.2	0.4	1.7	0.1	0.2	0.8	-0.0	0.1	1.3	-0.2
Short access total infusions	0.3	0.4	0.8	-0.9	-0.9	0.0	0.8	-0.8	0.2	0.2
Short access day 1 locomotion	0.8	1.3	1.8	-0.8	-1.3	-1.3	1.0	-1.0	-1.2	1.2
Short access day 10 total locomotion	0.3	1.1	1.8	-1.0	-1.2	-1.1	1.1	-0.9	-0.8	1.3
Short access total locomotion	0.8	1.3	1.7	-0.9	-1.3	-1.3	1.1	-1.0	-1.0	1.3
One hour access (0.3 mA shock)	0.4	0.5	0.9	0.3	0.7	0.9	-0.6	0.5	0.6	-0.8
Compulsive drug intake	1.2	1.8	2.5	1.1	1.5	1.3	-1.6	1.5	1.1	-1.2
One hour access (shock baseline)	0.1	0.2	0.5	-0.2	0.3	0.7	0.1	-0.0	0.6	-0.6
Social response proportion	0.3	0.4	1.3	-0.1	-0.7	-0.4	1.1	-0.7	-0.2	-0.2
Social responses	0.1	0.1	0.3	-0.0	-0.5	-0.3	0.4	-0.2	-0.3	0.0
Social time	0.2	0.2	0.9	0.3	0.0	-1.0	0.1	0.0	-0.8	0.1
Soleus weight	1.0	2.9	5.7	1.9	2.0	0.7	-2.3	2.4	0.9	-0.3
Bone: stiffness	1.5	2.8	6.5	2.0	1.6	-2.6	-1.2	0.8	-2.2	0.3
Tibialis anterior weight	0.2	0.6	1.0	0.2	1.0	0.7	-0.8	0.7	0.8	-0.8
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.0	-0.3	-0.1	-0.2	-0.0	-0.0	-0.1
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.5	-1.2	-0.8	-0.3	0.9	-1.0	-0.5	-0.1
Time to tail flick, test, before self-admin	0.3	0.4	1.4	-0.4	-0.6	0.4	1.2	-0.6	0.2	-0.3
Time to tail flick, test, after self-admin	1.9	2.0	4.0	-1.4	-2.0	-0.4	2.0	-1.7	-0.8	0.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.8	-0.4	0.5	0.9	0.2	-0.0	0.8	-0.8
Delta time to tail flick, test, before/after SA	1.3	1.6	3.1	-0.9	-1.1	-1.5	0.6	-1.0	-1.8	1.4
Tibia length	7.2	20.1	32.9	5.7	4.7	-3.7	-5.7	4.9	-3.2	2.4
Ambulatory time before self-admin	0.3	1.0	2.9	1.7	0.6	-0.6	-0.9	1.2	-0.7	0.9
Ambulatory time after self-admin	0.2	0.3	0.8	0.4	0.4	0.9	0.3	0.3	0.3	-0.8
Bone: tissue strength	2.3	2.5	5.8	2.4	2.1	-0.7	-1.8	1.7	-0.5	-0.4
Total heroin consumption	2.0	2.4	5.2	-0.4	-0.8	-2.2	1.4	-1.2	-2.3	1.5
Bone: trabecular number	0.1	0.1	0.4	0.0	0.2	0.6	-0.2	0.4	0.4	0.0
Bone: trabecular spacing	1.4	2.0	4.9	1.4	1.4	1.3	-0.5	0.8	1.6	-2.2
Bone: trabecular thickness	0.5	0.7	2.9	-0.1	-0.1	-0.7	-0.5	0.3	-1.0	1.7
Bone: trabecular tissue density	0.4	0.7	1.8	-0.8	-1.0	-0.3	1.4	-1.2	-0.2	-0.2
Water consumed over 24 hours	0.1	0.2	0.6	-0.8	-0.5	0.2	-0.2	-0.1	-0.1	0.8
Number of responses in last shaping day	0.5	0.6	1.1	-0.6	-0.8	-0.9	0.8	-0.7	-1.1	0.5