Fmnl3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_003752125.6 0.02 0.02 8.4e-03 0.02 0.02 0.02 -0 4.2e-03 4.8e-03 5.8e-03 7.3e-01
2 Adipose gene expression Fmnl3 0.04 0.05 1.0e-03 0.02 0.02 0.03 0.02 1.6e-03 1.1e-03 2.9e-04 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density6.411.112.73.6-3.1
Area under the delay curve0.80.91.81.4-0.2
BMI with tail5.017.426.75.2-2.8
BMI without tail1.23.65.92.4-1.1
Body weight4.720.532.35.7-3.0
Weight adjusted by age1.32.02.01.4-1.4
Bone surface8.214.917.34.2-3.6
Bone volume6.110.913.63.7-2.9
Breakpoint value in progressive ratio session0.81.01.01.0-1.0
Number of licking bursts0.60.91.9-1.4-0.0
Context. condit. distance diff. score0.10.10.10.4-0.1
Locomotion velocity, session 11.21.32.5-1.6-0.1
Locomotion distance, session 11.72.13.4-1.80.9
Locomotion velocity, session 20.10.10.2-0.50.1
Locomotion distance, session 21.31.83.0-1.70.7
Locomotion velocity, session 33.23.65.9-2.41.2
Locomotion distance, session 33.74.04.2-2.01.9
Stereotopy head waving bouts, day 31.11.32.40.6-1.5
Stereotopy head waving duration, day 30.80.91.70.4-1.3
Locomotion velocity, session 70.80.91.6-1.3-0.5
Locomotion distance, session 71.51.93.8-1.90.1
Stereotopy head waving bouts, day 70.81.01.10.9-1.0
Stereotopy head waving duration, day 70.70.81.21.1-0.6
Locomotion velocity, session 80.10.20.2-0.5-0.2
Locomotion distance, session 80.81.21.8-1.30.7
Degree of sensitization distance0.80.81.50.3-1.2
Degree of sensitization stereotypy0.10.10.20.50.2
Conditioned locomotion0.30.30.6-0.3-0.8
Cocaine response after cond. corrected0.00.00.00.00.1
Cocaine response after cond. not corrected0.50.60.8-0.60.9
Cocaine response before conditioning2.93.43.6-1.91.8
Saline control response0.00.00.1-0.1-0.2
Bone: connectivity density4.67.37.82.6-2.8
Bone: cortical apparent density0.10.10.2-0.40.3
Bone: cortical area7.511.511.83.4-3.3
Bone: cortical porosity0.50.61.0-0.31.0
Bone: cortical porosity0.60.61.0-0.51.0
Bone: cortical thickness2.44.14.41.9-2.1
Bone: cortical thickness0.10.10.3-0.0-0.5
Bone: cortical tissue density0.10.20.2-0.50.3
Condit. Reinf. active minus inactive responses0.10.10.2-0.5-0.1
Condit. Reinf. active-inactive response ratio0.40.40.70.3-0.8
Condit. Reinf. active responses0.50.61.0-1.00.5
Condit. Reinf. inactive responses2.53.13.2-1.81.7
Incentive salience index mean0.00.00.1-0.1-0.2
Condit. Reinf. lever presses0.10.10.20.50.1
Condit. Reinf. active minus inactive responses0.30.30.50.30.7
Condit. Reinf. active-inactive response ratio0.70.81.70.11.3
Condit. Reinf. active responses0.30.40.8-0.10.9
Condit. Reinf. inactive responses0.40.50.7-0.80.6
Condit. Reinf. lever presses0.00.00.00.00.2
Condit. Reinf. lever reinforcers received0.50.61.0-0.51.0
Conditioned reinforcement - actives1.22.03.6-0.71.9
Conditioned reinforcement - inactives3.24.75.9-2.41.9
Conditioned locomotion0.20.20.4-0.60.2
Patch foraging indifference point 0 sec2.54.79.4-3.1-0.0
Patch foraging indifference point AUC0.60.91.2-1.10.7
Delay disc. indifference point, 0s delay0.91.01.81.4-0.3
Delay disc. indifference point, 16s delay0.70.71.41.2-0.3
Delay disc. indifference point, 2s delay1.31.52.61.6-0.6
Delay disc. indifference point, 24s delay0.80.91.10.8-1.0
Delay disc. indifference point, 4s delay0.80.81.61.30.3
Delay disc. indifference point, 8s delay1.31.62.31.5-0.9
Indifference point function ln k2.23.96.32.5-1.2
Indifference point function log k2.23.96.32.5-1.2
Patch foraging total patch changes 0 sec2.44.59.0-3.0-0.0
Patch foraging total patch changes 12 sec2.73.57.0-2.60.3
Patch foraging total patch changes 18 sec3.55.310.2-3.20.6
Patch foraging total patch changes 24 sec1.93.26.5-2.50.2
Patch foraging total patch changes 6 sec3.24.89.6-3.10.1
Patch foraging time to switch 0 sec1.32.73.9-2.01.3
Patch foraging water rate 0 sec1.93.95.62.4-1.5
Patch foraging water rate 12 sec2.14.35.02.2-1.9
Patch foraging water rate 18 sec0.30.50.80.9-0.5
Patch foraging water rate 24 sec2.73.87.22.7-0.6
Patch foraging water rate 6 sec3.55.18.42.9-1.3
Seeking ratio, delayed vs. immediate footshock0.10.10.10.4-0.1
Distance traveled before self-admin0.81.12.0-1.4-0.3
Distance traveled after self-admin0.70.91.5-1.2-0.6
Extensor digitorum longus weight2.610.319.54.4-1.1
Bone: elastic displacement2.83.25.8-2.40.8
Bone: elastic work0.10.10.20.1-0.4
Bone: endosteal estimation6.013.117.54.2-2.9
Bone: endosteal perimeter5.211.214.93.9-2.7
Epididymis fat weight0.82.63.61.3-1.9
Delta time in closed arm before/after self-admin0.10.10.2-0.4-0.2
Delta time in open arm before/after self-admin0.80.80.9-1.00.8
Diff in mean of infusions in LGA sessions0.81.01.31.2-0.9
Delay discount exponential model param0.80.91.8-1.40.2
Extinction: sum of active levers before priming1.51.72.51.6-0.9
Active lever presses in extinction session 61.01.01.70.5-1.3
Bone: final force7.812.518.94.3-2.5
Bone: final moment8.613.820.94.6-2.6
Food consumed during 24 hour testing period0.81.11.31.1-0.9
Glucose0.61.01.8-0.3-1.3
Heart weight0.10.20.30.60.1
Delay discount hyperbolic model param0.80.91.8-1.30.2
Intermittent access intake day 1-15 change0.30.71.20.41.1
Intermittent access intake escalation0.40.81.20.71.1
Intermittent access intake escalation 20.60.71.30.11.2
Intermitt. access day 1 inactive lever presses0.20.60.9-0.51.0
Intermitt. access day 15 inactive lever presses0.81.73.1-0.41.8
Intermitt. access escalation Index0.60.91.60.4-1.3
Intermittent access day 1 total infusions0.91.42.1-1.40.8
Intermittent access day 15 total infusions1.01.62.4-0.91.5
Intermittent access terminal intake (last 3 days)1.51.92.7-1.11.7
Intermittent access total infusions1.92.32.7-1.31.6
Intermittent access day 1 locomotion0.30.30.7-0.8-0.1
Intermittent access day 15 total locomotion0.20.40.6-0.80.5
Intermittent access total locomotion1.41.72.8-1.70.8
Intermittent access standard deviation0.30.71.3-0.11.1
Left kidney weight0.73.56.52.5-0.7
Right kidney weight3.214.623.14.8-2.5
Cocaine induced anxiety1.92.64.22.1-1.0
Post-drug Anxiety2.72.95.12.3-0.8
Baseline Anxiety0.10.10.10.30.0
Tail length0.00.10.1-0.3-0.2
Length with tail1.04.46.22.5-1.6
Length without tail3.912.719.04.4-2.5
Times rat made contact with spout0.20.20.3-0.50.5
Lifetime Intake2.53.13.2-1.71.8
Liver weight, left7.312.117.24.1-2.6
Liver weight, right2.13.75.82.4-1.3
Locomotor activity1.21.82.0-1.41.3
Locomotor testing distance2.24.05.7-2.41.6
Locomotor testing rearing1.73.43.8-1.91.7
Locomotion in novel chamber1.82.24.52.10.1
Locomotion in novel chamber post-restriction0.20.30.40.30.6
Fecal boli incidents, locomotor time 10.81.21.3-1.11.1
Change in fecal boli incidents, locomotor task0.60.50.90.5-0.9
Time >=10cm from walls, locomotor time 10.30.30.7-0.2-0.8
Bouts of movement, locomotor time 10.00.00.0-0.10.1
Total resting periods, locomotor time 10.30.30.6-0.80.3
Rest time, locomotor task time 10.50.71.3-1.2-0.1
Distance moved, locomotor task time 10.00.10.1-0.1-0.3
Vertical activity count, locomotor time 10.41.01.51.2-0.7
Time >=10cm from walls, locomotor time 20.40.61.0-0.51.0
Bouts of movement, locomotor time 21.21.92.91.7-1.0
Total resting periods, locomotor time 21.22.23.01.7-1.1
Rest time, locomotor task time 20.40.50.5-0.7-0.7
Distance moved, locomotor task time 20.10.10.20.10.5
Vertical activity count, locomotor time 20.20.20.30.50.4
Light reinforcement 11.43.53.5-1.91.8
Light reinforcement 20.50.81.3-0.61.2
Bone: marrow area5.912.816.64.1-3.0
Bone: maximum diameter2.95.45.92.2-2.4
Bone: maximum force11.620.628.55.3-3.6
Bone: maximum moment12.521.930.95.6-3.6
Mean time between licks in bursts0.00.10.1-0.20.3
Mean num. licks in bursts0.20.40.40.70.5
Cd content in liver0.50.60.6-0.70.8
Co content in liver0.20.30.3-0.50.5
Cu content in liver0.50.60.80.6-0.9
Fe content in liver1.41.82.1-1.41.2
K content in liver0.00.00.0-0.10.0
Mg content in liver0.20.20.3-0.50.3
Mn content in liver0.00.00.1-0.0-0.3
Na content in liver0.10.10.20.10.5
Rb content in liver0.70.81.3-1.1-0.6
Se content in liver1.51.83.6-1.90.2
Sr content in liver0.80.71.00.7-1.0
Zn content in liver0.80.91.3-1.10.8
Bone: minimum diameter6.912.615.74.0-3.1
Time in familiar zone, hab. session 10.30.20.4-0.20.7
Time in novel zone, hab. session 10.30.30.50.2-0.7
Total zone transitions, hab. session 10.20.30.5-0.30.7
Total locomotion distance, hab. session 10.30.40.8-0.3-0.9
Locomotion velocity, hab. session 10.20.30.7-0.2-0.8
Time in familiar zone, hab. session 20.50.51.01.00.3
Time in novel zone, hab. session 20.60.61.0-1.0-0.5
Total zone transitions, hab. session 20.20.30.3-0.50.6
Total locomotion distance, hab. session 20.20.20.3-0.6-0.4
Locomotion velocity, hab. session 20.10.20.2-0.4-0.4
Novel to familiar place preference ratio1.41.52.01.0-1.4
Novelty place preference1.21.32.00.7-1.4
Time in novel zone, NPP test1.11.22.00.6-1.4
Total zone transitions, NPP test1.11.63.1-1.80.4
Total locomotion distance, NPP test1.42.03.9-2.00.0
Locomotion velocity, NPP test0.91.32.6-1.6-0.2
Intraocular pressure4.86.910.2-3.21.9
Delta distance traveled before/after self-admin0.00.00.0-0.10.0
Delta ambulatory time before/after self-admin0.10.10.1-0.30.3
Parametrial fat weight1.12.63.9-1.12.0
Pavlov. Cond. lever latency0.40.51.0-0.1-1.0
Pavlov. Cond. magazine entry latency0.70.91.20.81.1
Pavlov. Cond. change in total contacts0.70.80.80.90.9
Pavlov. Cond. index score0.50.60.70.70.8
Pavlov. Cond. latency score0.40.50.70.60.8
Pavlov. Cond. lever contacts0.91.12.2-0.11.5
Pavlov. Cond. magazine entry number0.40.50.7-0.6-0.8
Pavlov. Cond. intertrial magazine entries1.51.82.8-1.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.70.91.00.7
Pavlov. Cond. response bias0.40.51.00.31.0
Pavlov. Cond. lever latency0.30.40.80.90.1
Pavlov. Cond. magazine entry latency1.31.63.10.3-1.8
Pavlov. Cond. change in total contacts0.71.11.40.9-1.2
Pavlov. Cond. index score0.71.02.0-0.1-1.4
Pavlov. Cond. latency score0.81.02.0-0.1-1.4
Pavlov. Cond. lever contacts0.20.30.5-0.7-0.2
Pavlov. Cond. magazine entry number2.32.95.3-0.62.3
Pavlov. Cond. intertrial magazine entries4.16.17.1-2.32.7
Pavlov. Cond. lever-magazine prob. diff.0.91.22.40.1-1.5
Pavlov. Cond. response bias0.10.20.3-0.3-0.5
Time in closed arm before self-admin1.52.03.21.8-0.8
Time in closed arm after self-admin0.10.10.10.30.1
Time in open arm before self-admin0.50.50.6-0.6-0.8
Time in open arm after self-admin0.10.10.1-0.3-0.3
Bone: periosteal estimation9.119.223.34.8-3.9
Bone: periosteal perimeter7.913.617.24.1-3.2
Bone: post-yield work6.79.813.83.7-2.4
Progressive ratio test 1 active lever presses4.96.19.3-3.11.7
Progressive ratio test 1 breakpoint4.75.89.0-3.01.6
Progressive ratio test 1 inactive lever presses2.53.56.0-1.02.5
Progressive ratio test 2 active lever presses1.82.12.8-1.21.7
Progressive ratio test 2 breakpoint1.72.02.7-1.11.6
Progressive ratio test 2 inactive lever presses1.22.03.2-0.91.8
Incentive Sensitization - Responses0.50.70.91.00.7
Incentive Sensitization - Breakpoint0.50.60.70.80.7
Sum of active levers in priming session hrs 5-60.40.30.5-0.5-0.7
Progressive ratio0.40.61.1-1.1-0.3
Food seeking constrained by brief footshock0.81.02.0-1.40.0
Seeking ratio, punishment vs. effort0.00.00.10.10.2
Retroperitoneal fat weight0.21.02.0-1.40.3
Reaction time number correct1.02.02.01.4-1.4
Reaction time mean minus median3.38.310.4-3.22.5
Reaction time mean minus median AUC2.25.67.0-2.62.1
Reaction time num false alarms1.11.52.7-1.70.5
Reaction time num false alarms AUC1.32.03.2-1.80.9
Reaction time trials correct on left1.02.02.01.4-1.4
Reaction time trials on left0.91.61.61.3-1.3
Reaction time mean0.50.81.3-1.20.5
Reaction time mean AUC0.30.50.8-0.90.3
Median of all reaction times0.00.10.1-0.1-0.3
Reaction time omissions6.59.511.8-3.42.7
Reaction time false alarm rate1.92.63.6-1.91.3
Reaction time premature initiation rate5.27.39.8-2.23.1
Reaction time premature initiations2.03.55.4-1.32.3
Std. dev. reaction times3.56.49.0-3.02.0
Reaction time trials completed0.91.61.61.3-1.3
Reaction time trials AUC1.32.52.61.6-1.5
Run reversals in cocaine runway, females0.40.40.40.60.7
Run reversals in cocaine runway, males1.01.01.2-1.10.9
Latency to leave start box in cocaine runway0.10.10.20.00.4
Latency to leave start box in cocaine runway, F0.70.80.9-0.81.0
Latency to leave start box in cocaine runway, M1.11.01.51.2-0.8
Std. dev. time between licks in bursts0.81.01.9-1.40.4
Total sessions with >9 infusions2.42.93.2-1.81.6
Short access day 1 total inactive lever presses1.62.12.2-1.51.4
Short access day 10 total inactive lever presses0.00.10.1-0.40.2
Short access day 1 total infusions0.91.21.6-1.20.9
Short access day 10 total infusions1.82.33.2-1.81.2
Short access total infusions2.83.64.7-2.21.6
Short access day 1 locomotion0.40.50.6-0.80.6
Short access day 10 total locomotion0.10.20.3-0.60.4
Short access total locomotion1.01.21.6-1.30.9
One hour access (0.3 mA shock)1.21.32.60.31.6
Compulsive drug intake0.10.20.30.30.5
One hour access (shock baseline)0.50.71.20.41.1
Social response proportion0.30.40.5-0.50.7
Social responses6.17.88.4-2.92.7
Social time0.60.81.00.81.0
Soleus weight0.51.42.71.6-0.5
Bone: stiffness13.021.232.35.7-3.2
Tibialis anterior weight1.34.47.42.71.2
Time to tail flick, vehicle, before self-admin1.11.21.3-1.21.0
Time to tail flick, vehicle, after self-admin0.40.60.80.90.6
Time to tail flick, test, before self-admin0.30.30.6-0.10.8
Time to tail flick, test, after self-admin0.60.71.31.1-0.1
Delta time to tail flick, vehicle, before/after SA0.40.40.70.8-0.1
Delta time to tail flick, test, before/after SA0.10.20.20.4-0.4
Tibia length4.813.313.63.7-3.6
Ambulatory time before self-admin1.11.73.1-1.80.5
Ambulatory time after self-admin1.31.53.1-1.70.2
Bone: tissue strength0.90.91.71.3-0.5
Total heroin consumption0.80.91.20.8-1.1
Bone: trabecular number4.47.47.82.6-2.8
Bone: trabecular spacing1.62.12.2-1.51.4
Bone: trabecular thickness0.40.51.00.21.0
Bone: trabecular tissue density0.20.30.40.30.6
Water consumed over 24 hours0.00.00.1-0.2-0.3
Number of responses in last shaping day0.20.20.4-0.20.6