Hub : Genes

Fmnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr10_88627953_88630432 0.04 0.02 1.6e-03 0.03 0.02 0.01 0.01 1.0e-03 9.1e-03 3.9e-02 1.3e-02
2 NAcc gene expression Fmnl1 0.02 0.01 1.0e-03 0.01 0.02 0.01 0.01 2.9e-02 5.4e-04 2.6e-02 1.4e-02
3 Liver alternative polyA NM_001105846.1 0.07 0.05 4.0e-03 0.03 0.02 0.01 0.01 6.2e-04 4.8e-03 7.9e-03 7.0e-03
4 Brain alternative polyA NM_001105846.1 0.23 0.08 0.0e+00 0.19 0.2 0.2 0.2 3.3e-17 1.0e-18 3.4e-18 9.6e-19
5 Brain alternative polyA XM_006247499.5 0.22 0.08 0.0e+00 0.18 0.19 0.18 0.2 3.8e-16 8.6e-18 2.0e-16 6.2e-18
6 pVTA alternative polyA NM_001105846.1 0.04 0.03 2.1e-03 0.02 0.03 0.04 0.04 8.7e-03 1.2e-03 5.9e-04 7.7e-04
7 Liver gene expression Fmnl1 0.02 0.02 3.9e-03 0.02 0.01 0.01 0.01 1.3e-03 2.9e-02 6.1e-02 3.9e-02
8 PL gene expression Fmnl1 0.06 0.03 3.6e-06 0.06 0.05 0.04 0.05 3.4e-07 4.7e-06 7.2e-05 3.2e-06
9 Adipose gene expression Fmnl1 0.25 0.09 0.0e+00 0.2 0.17 0.18 0.19 1.2e-21 7.2e-19 6.0e-20 2.4e-20
10 Adipose mRNA stability Fmnl1 0.09 0.04 3.6e-10 0.06 0.07 0.06 0.07 1.1e-07 2.1e-08 2.0e-07 3.8e-08
11 Brain mRNA stability Fmnl1 0.14 0.08 7.2e-05 0.01 0.04 0.04 0.03 2.0e-02 4.8e-05 1.4e-04 1.0e-03
12 Adipose isoform ratio NM_001105846.1 0.09 0.06 1.0e-03 0.01 0.03 0.02 0.01 3.2e-02 3.5e-04 1.6e-03 7.5e-03
13 Brain gene expression Fmnl1 0.09 0.04 1.1e-05 0.03 0.06 0.05 0.04 1.0e-03 5.2e-06 3.9e-05 6.9e-05
14 Adipose alternative polyA XM_006247499.5 0.15 0.06 1.9e-09 0.03 0.07 0.08 0.07 1.1e-04 1.2e-08 4.7e-09 1.4e-08
15 Adipose alternative polyA NM_001105846.1 0.15 0.06 2.8e-09 0.03 0.07 0.08 0.07 1.4e-04 1.7e-08 7.1e-09 1.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.93.35.4-1.8-1.92.1-2.12.0-1.22.0-2.01.92.1-0.81.7-2.3-1.21.2
Area under the delay curve0.10.10.9-0.00.1-0.90.0-0.1-0.1-0.10.0-0.4-0.40.2-0.60.40.4-0.4
BMI with tail1.24.19.20.52.8-0.52.0-2.12.9-2.42.2-2.8-2.33.0-1.51.00.00.0
BMI without tail0.51.67.6-1.31.30.30.7-0.81.5-1.11.1-1.7-1.22.7-1.3-0.10.5-0.5
Body weight0.94.222.8-2.01.52.31.2-1.32.8-1.51.7-2.2-1.84.8-2.00.40.3-0.3
Weight adjusted by age0.50.82.9-0.5-0.3-0.60.2-0.2-0.0-0.10.2-0.2-0.70.9-1.71.31.5-1.6
Bone surface2.74.912.8-3.6-2.81.2-2.82.8-1.82.7-2.72.52.3-0.10.3-2.50.1-0.1
Bone volume2.24.07.8-2.8-2.31.3-2.62.6-1.72.4-2.42.12.3-0.30.8-2.5-0.60.6
Breakpoint value in progressive ratio session1.01.23.1-1.1-1.2-1.8-0.90.9-1.30.9-0.80.70.4-0.9-0.4-0.21.6-1.6
Number of licking bursts1.11.93.40.51.10.21.8-1.81.8-1.31.8-1.2-1.71.3-0.91.41.1-1.1
Context. condit. distance diff. score1.92.24.11.71.80.41.7-1.81.5-2.01.7-1.9-1.61.4-0.71.7-0.10.0
Locomotion velocity, session 10.40.40.8-0.2-0.50.5-0.80.8-0.70.5-0.60.60.9-0.20.4-0.7-0.60.7
Locomotion distance, session 10.20.20.60.0-0.10.0-0.60.5-0.50.0-0.60.10.7-0.20.4-0.7-0.70.8
Locomotion velocity, session 20.91.02.00.0-1.00.9-1.21.2-1.21.1-1.31.11.4-1.10.8-0.6-0.80.8
Locomotion distance, session 20.30.51.2-0.2-0.60.2-0.80.8-0.90.6-0.80.71.1-0.70.4-0.8-0.40.4
Locomotion velocity, session 30.40.41.90.10.11.2-0.20.20.4-0.0-0.3-0.00.20.40.7-0.4-1.41.4
Locomotion distance, session 30.30.30.90.30.40.40.6-0.60.8-0.90.6-0.7-0.70.8-0.40.7-0.10.1
Stereotopy head waving bouts, day 30.91.04.10.50.2-0.2-0.70.7-0.30.5-1.00.20.7-1.11.5-0.9-2.02.0
Stereotopy head waving duration, day 30.30.30.90.70.4-0.8-0.30.3-0.40.4-0.6-0.10.2-0.90.8-0.2-0.90.9
Locomotion velocity, session 70.80.92.31.21.01.10.7-0.80.9-0.30.7-0.7-0.30.11.10.2-1.51.5
Locomotion distance, session 70.20.30.80.90.50.80.6-0.60.4-0.30.4-0.6-0.40.4-0.10.8-0.10.0
Stereotopy head waving bouts, day 70.60.71.9-0.3-0.80.6-0.40.5-0.11.2-0.71.30.7-1.41.3-0.6-0.70.7
Stereotopy head waving duration, day 70.60.73.30.3-0.40.1-0.00.2-0.11.0-0.41.10.6-1.81.5-0.3-0.80.8
Locomotion velocity, session 80.50.61.80.41.30.40.4-0.50.9-1.10.5-1.1-0.31.00.1-0.4-0.91.0
Locomotion distance, session 80.20.31.51.20.70.10.5-0.50.1-0.90.5-0.7-0.20.1-0.10.6-0.30.3
Degree of sensitization distance0.10.20.6-0.00.30.50.1-0.1-0.1-0.00.1-0.4-0.20.8-0.60.40.5-0.5
Degree of sensitization stereotypy0.30.31.0-0.0-0.51.00.1-0.00.31.0-0.11.00.3-0.90.90.1-0.20.2
Conditioned locomotion0.10.10.60.20.00.80.0-0.0-0.0-0.1-0.1-0.1-0.00.10.5-0.0-0.70.7
Cocaine response after cond. corrected0.50.65.5-0.10.12.30.1-0.11.0-0.10.10.00.01.00.40.0-1.00.9
Cocaine response after cond. not corrected1.11.311.7-0.5-0.73.4-0.50.50.50.6-0.50.90.80.60.9-0.5-1.21.1
Cocaine response before conditioning0.81.01.8-0.6-1.20.9-1.21.2-0.91.3-1.11.31.3-1.10.8-1.00.0-0.1
Saline control response0.20.30.9-0.7-0.3-0.6-0.40.3-0.60.3-0.3-0.00.1-0.1-0.2-0.60.9-0.9
Bone: connectivity density2.53.96.6-2.4-2.61.7-2.42.4-1.92.4-2.32.42.3-0.90.9-2.1-0.20.2
Bone: cortical apparent density1.62.110.42.30.3-0.8-0.10.1-0.70.4-0.60.60.9-3.22.5-0.4-1.91.9
Bone: cortical area1.82.85.4-2.2-1.60.4-2.02.0-1.12.2-2.01.81.9-0.51.0-2.3-1.11.0
Bone: cortical porosity4.75.017.7-4.2-2.91.4-2.82.8-1.92.2-2.42.01.91.3-1.1-2.11.1-1.1
Bone: cortical porosity2.52.811.9-3.5-1.71.7-2.01.9-0.81.4-1.61.11.21.9-1.0-1.70.5-0.5
Bone: cortical thickness1.62.78.60.3-0.42.1-0.40.50.21.5-0.71.31.4-1.42.9-1.5-2.92.8
Bone: cortical thickness2.12.54.8-0.1-1.52.1-1.01.1-1.12.1-1.22.11.7-1.62.2-0.9-1.71.6
Bone: cortical tissue density1.62.110.92.30.2-0.9-0.10.2-0.80.5-0.60.60.9-3.32.5-0.4-1.71.7
Condit. Reinf. active minus inactive responses0.91.13.0-1.1-1.3-0.9-0.70.7-1.30.9-0.50.70.30.1-1.30.11.7-1.7
Condit. Reinf. active-inactive response ratio0.80.93.6-0.4-0.8-0.8-0.10.1-0.90.3-0.10.3-0.20.3-1.61.01.9-1.9
Condit. Reinf. active responses1.01.32.9-1.3-1.4-0.7-1.31.3-1.71.4-1.20.90.9-0.4-0.6-0.71.3-1.2
Condit. Reinf. inactive responses1.31.64.1-0.8-0.70.5-1.71.6-1.11.3-1.60.81.5-1.01.5-2.0-1.01.0
Incentive salience index mean1.01.32.5-1.3-1.6-0.7-1.11.0-1.51.4-0.81.20.7-0.4-0.8-0.41.5-1.5
Condit. Reinf. lever presses0.60.81.7-0.7-1.00.0-1.11.1-1.01.3-1.01.01.1-0.90.5-1.10.2-0.1
Condit. Reinf. active minus inactive responses3.84.99.5-2.9-3.11.1-2.62.7-2.73.0-2.52.52.2-0.5-0.4-1.41.4-1.4
Condit. Reinf. active-inactive response ratio2.93.47.3-2.7-2.60.4-1.91.9-2.02.5-1.72.11.5-0.3-0.9-0.81.9-2.0
Condit. Reinf. active responses4.15.711.1-2.8-3.30.6-2.92.9-3.23.2-2.82.62.5-0.8-0.4-1.61.5-1.5
Condit. Reinf. inactive responses1.51.94.4-0.5-1.5-0.1-1.81.8-2.11.5-1.71.31.8-1.40.8-1.5-0.20.3
Condit. Reinf. lever presses1.82.56.0-1.5-2.1-0.3-1.91.9-2.42.2-1.81.61.6-0.9-0.1-1.00.9-1.0
Condit. Reinf. lever reinforcers received3.75.19.9-2.5-3.10.4-2.82.8-3.13.0-2.72.42.4-0.9-0.2-1.51.3-1.3
Conditioned reinforcement - actives0.10.21.4-0.60.0-1.20.1-0.1-0.3-0.00.1-0.3-0.30.0-0.20.00.7-0.7
Conditioned reinforcement - inactives0.30.52.9-1.7-0.50.5-0.70.7-0.10.6-0.60.40.60.30.4-1.3-0.20.3
Conditioned locomotion0.50.61.9-1.0-0.3-0.60.1-0.2-0.2-0.20.3-0.4-0.61.3-1.40.51.3-1.3
Patch foraging indifference point 0 sec2.03.75.7-1.2-1.51.6-2.32.3-2.01.9-2.41.52.3-1.12.0-2.4-1.81.9
Patch foraging indifference point AUC0.40.61.5-0.4-0.11.10.6-0.60.3-0.60.5-0.3-0.51.2-1.00.71.1-1.1
Delay disc. indifference point, 0s delay0.20.20.80.2-0.3-0.9-0.20.2-0.60.2-0.30.0-0.0-0.4-0.50.60.7-0.7
Delay disc. indifference point, 16s delay0.80.91.50.30.9-0.80.9-0.91.0-0.91.0-1.1-1.21.2-1.11.00.4-0.4
Delay disc. indifference point, 2s delay1.31.53.1-1.2-1.6-0.1-1.81.7-1.61.2-1.71.11.3-0.6-0.1-0.90.5-0.5
Delay disc. indifference point, 24s delay0.20.30.8-0.3-0.10.30.2-0.2-0.1-0.10.2-0.2-0.40.8-0.90.70.9-0.9
Delay disc. indifference point, 4s delay0.20.21.50.1-0.1-1.2-0.10.1-0.4-0.2-0.2-0.3-0.2-0.1-0.60.50.6-0.7
Delay disc. indifference point, 8s delay0.10.20.60.1-0.0-0.6-0.20.2-0.30.4-0.30.20.2-0.80.5-0.2-0.60.6
Indifference point function ln k0.91.52.8-0.9-1.20.0-1.51.5-1.11.7-1.21.51.4-0.91.0-1.4-1.11.1
Indifference point function log k0.91.52.8-0.9-1.20.0-1.51.5-1.11.7-1.21.51.4-0.91.0-1.4-1.11.1
Patch foraging total patch changes 0 sec2.14.06.7-1.5-1.51.6-2.42.4-1.92.0-2.41.62.4-1.01.9-2.6-2.02.0
Patch foraging total patch changes 12 sec1.92.44.8-1.1-1.70.9-2.02.0-2.21.4-2.21.42.0-1.21.0-1.9-0.20.3
Patch foraging total patch changes 18 sec0.20.30.8-0.9-0.70.9-0.70.7-0.60.3-0.80.20.50.4-0.1-0.4-0.10.1
Patch foraging total patch changes 24 sec1.72.95.0-1.3-1.51.4-2.02.0-1.61.6-2.21.42.0-1.11.7-2.2-1.51.5
Patch foraging total patch changes 6 sec0.50.82.3-0.6-1.01.5-1.01.0-1.00.7-1.10.71.1-0.10.8-1.0-0.70.7
Patch foraging time to switch 0 sec0.10.10.40.30.10.00.1-0.1-0.1-0.00.1-0.6-0.20.1-0.60.60.6-0.6
Patch foraging water rate 0 sec0.10.31.3-0.50.20.3-0.30.30.20.1-0.20.20.30.40.6-0.7-1.21.1
Patch foraging water rate 12 sec0.20.51.70.10.30.80.6-0.60.9-0.00.6-0.1-0.40.70.20.6-1.31.2
Patch foraging water rate 18 sec1.72.66.30.0-0.42.3-1.11.2-0.31.6-1.31.31.5-1.22.5-1.6-2.52.5
Patch foraging water rate 24 sec0.50.82.50.60.0-0.0-0.70.7-0.40.8-0.90.60.7-1.01.2-0.5-1.61.5
Patch foraging water rate 6 sec0.60.81.7-1.1-1.11.0-1.01.0-0.51.2-0.81.31.0-0.20.6-1.0-0.70.6
Seeking ratio, delayed vs. immediate footshock2.22.66.4-0.51.1-0.61.3-1.31.2-1.51.5-1.9-1.82.5-2.51.61.9-1.8
Distance traveled before self-admin0.50.62.0-0.7-1.0-1.4-0.80.8-1.20.6-0.70.60.5-0.6-0.4-0.10.8-0.8
Distance traveled after self-admin0.20.32.00.30.1-1.40.0-0.0-0.4-0.1-0.1-0.2-0.20.0-0.70.40.6-0.6
Extensor digitorum longus weight4.818.930.23.44.8-2.65.1-5.24.3-4.95.1-5.4-5.53.7-3.65.21.8-1.8
Bone: elastic displacement0.40.42.6-0.4-0.81.6-0.10.10.10.70.00.90.5-0.20.8-0.3-0.40.4
Bone: elastic work1.11.43.0-1.4-1.51.7-1.21.2-0.81.5-1.01.41.3-0.21.0-1.4-0.50.5
Bone: endosteal estimation2.04.313.0-3.6-1.9-2.2-2.12.0-1.80.9-1.70.50.51.8-3.2-0.62.5-2.5
Bone: endosteal perimeter2.34.817.7-4.2-1.8-2.3-2.12.0-1.40.9-1.60.60.42.1-3.2-1.02.8-2.8
Epididymis fat weight0.10.41.3-0.60.60.40.4-0.41.1-0.10.5-0.7-0.61.2-0.70.20.5-0.5
Delta time in closed arm before/after self-admin2.92.77.32.02.30.21.4-1.42.0-1.41.4-1.5-0.70.11.5-0.4-2.72.7
Delta time in open arm before/after self-admin1.71.712.2-0.5-0.6-3.5-0.20.2-1.10.2-0.20.3-0.2-1.1-0.90.32.2-2.1
Diff in mean of infusions in LGA sessions0.40.51.1-0.8-0.8-0.8-0.50.5-1.00.7-0.50.70.4-0.6-0.2-0.21.1-1.0
Delay discount exponential model param0.10.20.90.1-0.10.9-0.00.00.10.20.00.40.4-0.30.6-0.4-0.50.5
Extinction: sum of active levers before priming0.10.11.20.10.2-1.1-0.0-0.0-0.4-0.3-0.0-0.3-0.1-0.50.5-0.30.1-0.0
Active lever presses in extinction session 61.41.45.0-2.2-1.0-1.2-0.60.6-0.70.6-0.50.4-0.10.7-1.3-0.22.1-2.1
Bone: final force2.03.25.8-1.4-1.41.2-2.02.0-1.21.9-2.11.82.2-1.01.9-2.4-1.91.8
Bone: final moment2.54.06.6-1.5-1.71.5-2.22.2-1.42.2-2.32.12.4-1.12.1-2.6-2.02.0
Food consumed during 24 hour testing period0.40.51.9-0.00.6-0.00.8-0.91.1-0.81.4-0.6-0.71.2-0.40.10.00.0
Glucose0.81.22.61.41.6-0.51.2-1.21.4-1.31.1-1.4-1.10.5-0.21.0-0.70.7
Heart weight1.62.47.3-0.71.71.21.6-1.62.7-1.41.6-1.7-1.92.6-0.60.6-0.40.4
Delay discount hyperbolic model param0.20.21.00.30.11.00.2-0.20.3-0.00.20.20.2-0.10.6-0.2-0.60.6
Intermittent access intake day 1-15 change0.51.02.91.01.7-0.70.8-0.91.5-1.40.9-1.6-0.90.8-0.30.3-0.60.6
Intermittent access intake escalation0.40.82.30.81.5-0.80.4-0.51.1-1.30.5-1.5-0.60.7-0.2-0.0-0.70.8
Intermittent access intake escalation 20.40.51.60.41.3-0.60.2-0.31.1-1.10.4-1.2-0.40.6-0.2-0.4-0.60.6
Intermitt. access day 1 inactive lever presses0.41.56.5-2.5-0.9-2.1-0.90.9-0.21.0-0.70.90.50.1-0.4-1.71.2-1.2
Intermitt. access day 15 inactive lever presses1.93.97.0-2.5-2.6-2.3-2.12.2-2.12.3-2.02.31.7-0.9-1.0-1.31.6-1.6
Intermitt. access escalation Index0.71.04.50.60.8-2.11.0-1.01.1-1.10.9-0.8-1.10.4-1.01.00.6-0.6
Intermittent access day 1 total infusions0.40.63.2-0.9-0.1-1.80.4-0.4-0.1-0.10.4-0.5-0.80.4-0.90.71.1-1.1
Intermittent access day 15 total infusions0.91.37.6-0.21.0-2.80.5-0.60.6-1.20.7-1.6-1.11.1-1.40.50.7-0.7
Intermittent access terminal intake (last 3 days)1.11.48.4-0.90.1-2.90.1-0.2-0.1-0.60.3-1.0-0.71.0-1.80.51.6-1.6
Intermittent access total infusions1.51.75.5-0.60.7-2.40.9-0.90.6-1.21.1-1.5-1.41.5-1.80.91.5-1.5
Intermittent access day 1 locomotion0.40.51.9-1.0-0.2-0.80.3-0.3-0.1-0.20.5-0.3-0.51.4-1.30.21.0-1.0
Intermittent access day 15 total locomotion0.40.72.70.10.8-0.50.7-0.70.4-0.90.9-1.2-0.81.6-1.20.60.4-0.3
Intermittent access total locomotion0.70.93.8-1.1-0.1-0.40.2-0.2-0.1-0.40.5-0.6-0.51.9-1.80.41.3-1.2
Intermittent access standard deviation0.10.21.2-0.30.3-1.1-0.30.30.2-0.0-0.2-0.20.2-0.50.4-1.00.3-0.2
Left kidney weight0.31.49.50.20.63.10.5-0.51.6-0.60.6-0.5-0.21.60.50.0-1.61.5
Right kidney weight0.42.08.9-0.40.93.01.1-1.12.2-1.01.3-1.1-1.02.5-0.20.5-1.00.9
Cocaine induced anxiety0.81.25.30.60.82.30.4-0.41.2-0.20.3-0.00.1-0.11.5-0.6-1.81.8
Post-drug Anxiety0.91.09.8-0.40.23.10.1-0.10.8-0.00.20.20.20.70.9-0.6-1.11.1
Baseline Anxiety1.21.44.7-1.7-1.3-0.5-0.50.4-1.00.4-0.30.40.01.1-1.80.42.2-2.2
Tail length0.72.89.0-3.0-2.12.6-1.81.8-1.12.0-1.31.71.60.40.5-1.80.0-0.0
Length with tail0.41.912.1-2.7-0.53.5-0.30.30.70.30.1-0.20.02.9-0.6-0.6-0.10.1
Length without tail1.03.111.3-0.21.42.81.7-1.72.5-1.31.8-1.8-1.63.4-1.11.4-0.50.5
Times rat made contact with spout0.40.51.20.20.51.10.7-0.71.1-0.31.1-0.0-0.20.20.9-0.4-0.80.8
Lifetime Intake1.01.34.4-1.20.2-2.10.5-0.50.2-0.80.7-1.0-1.11.2-1.50.61.6-1.6
Liver weight, left0.61.04.3-2.1-0.82.0-0.70.70.20.5-0.40.50.61.7-0.7-0.70.2-0.2
Liver weight, right0.61.04.9-0.4-0.22.20.1-0.00.90.70.10.90.50.21.4-0.5-1.71.6
Locomotor activity1.32.03.5-1.9-1.7-0.2-1.81.8-1.71.5-1.71.51.4-0.6-0.0-1.51.0-1.0
Locomotor testing distance1.62.95.7-2.1-2.0-0.9-2.22.2-2.41.6-2.11.41.5-0.7-0.5-1.51.4-1.3
Locomotor testing rearing0.91.85.4-1.2-1.6-1.0-1.71.7-2.31.0-1.70.81.1-0.6-0.8-0.71.4-1.4
Locomotion in novel chamber1.11.43.4-0.6-1.61.5-0.90.9-1.40.7-0.71.00.71.0-1.80.91.4-1.4
Locomotion in novel chamber post-restriction0.20.30.9-0.7-0.20.5-0.60.5-0.20.3-0.40.30.60.30.3-1.0-0.70.7
Fecal boli incidents, locomotor time 10.10.20.70.10.20.3-0.20.20.10.3-0.30.20.4-0.60.8-0.6-0.70.7
Change in fecal boli incidents, locomotor task0.10.11.5-0.1-0.21.20.0-0.0-0.0-0.20.0-0.0-0.00.6-0.10.1-0.00.0
Time >=10cm from walls, locomotor time 10.50.52.30.80.10.40.9-0.80.3-0.10.7-0.1-0.70.4-0.71.50.5-0.6
Bouts of movement, locomotor time 10.60.61.81.30.9-0.61.0-1.01.1-0.80.9-0.5-0.8-0.20.20.7-0.40.4
Total resting periods, locomotor time 10.70.81.91.31.1-0.11.2-1.21.4-1.01.2-0.6-0.90.10.20.8-0.50.4
Rest time, locomotor task time 10.10.10.30.3-0.1-0.30.2-0.20.10.10.10.4-0.1-0.50.20.30.2-0.2
Distance moved, locomotor task time 10.40.62.6-0.40.30.30.4-0.40.4-0.80.5-0.8-0.71.6-1.40.70.8-0.8
Vertical activity count, locomotor time 10.20.52.0-0.10.3-0.50.2-0.30.3-0.80.4-0.7-0.71.2-1.40.70.7-0.7
Time >=10cm from walls, locomotor time 20.10.20.6-0.4-0.80.8-0.30.4-0.40.6-0.30.70.40.2-0.30.00.3-0.3
Bouts of movement, locomotor time 20.20.30.5-0.2-0.60.6-0.60.6-0.40.5-0.60.70.6-0.50.7-0.7-0.50.5
Total resting periods, locomotor time 20.10.20.60.1-0.20.4-0.30.30.00.2-0.30.40.3-0.40.7-0.4-0.80.7
Rest time, locomotor task time 20.81.02.10.81.2-0.81.4-1.41.4-1.11.4-1.0-1.20.5-0.10.8-0.30.3
Distance moved, locomotor task time 20.10.10.5-0.3-0.30.1-0.30.3-0.50.1-0.3-0.00.10.5-0.70.30.5-0.5
Vertical activity count, locomotor time 20.50.71.6-0.6-1.0-0.9-1.01.0-1.30.8-1.10.80.7-0.6-0.2-0.40.5-0.5
Light reinforcement 10.82.03.7-1.2-1.4-0.1-1.71.8-1.51.6-1.81.41.6-1.41.3-1.9-0.60.6
Light reinforcement 21.21.93.5-1.0-1.40.2-1.81.8-1.41.3-1.91.41.6-1.41.2-1.8-0.40.4
Bone: marrow area1.94.212.7-3.6-1.8-2.2-2.12.0-1.80.9-1.70.50.51.8-3.2-0.72.5-2.4
Bone: maximum diameter1.52.98.0-2.8-1.8-1.3-2.32.3-1.61.8-2.21.51.5-0.1-0.4-2.00.3-0.3
Bone: maximum force1.01.84.0-1.8-1.10.7-1.81.8-0.81.2-1.80.91.50.30.7-2.0-1.21.2
Bone: maximum moment1.42.44.4-1.9-1.31.1-2.12.0-1.11.5-2.01.21.80.10.8-2.1-1.31.3
Mean time between licks in bursts1.84.310.40.72.60.32.4-2.43.2-2.42.4-2.5-2.52.6-1.31.70.2-0.2
Mean num. licks in bursts0.71.02.3-0.2-0.40.0-1.11.1-0.90.7-0.80.81.2-1.01.2-1.4-1.51.5
Cd content in liver2.02.27.62.82.0-1.61.7-1.70.9-1.51.3-1.7-1.5-0.5-0.01.70.0-0.0
Co content in liver1.72.06.70.5-0.3-0.11.0-1.0-0.2-0.91.2-0.3-1.00.8-2.12.32.6-2.6
Cu content in liver0.40.51.4-0.9-1.1-0.10.1-0.0-0.30.80.21.10.1-0.4-0.40.11.2-1.2
Fe content in liver0.50.72.71.60.40.60.8-0.70.3-0.60.7-0.1-0.3-0.91.10.6-1.01.0
K content in liver1.81.74.5-0.7-2.10.1-0.91.0-1.71.9-1.12.11.3-1.80.5-0.30.9-0.9
Mg content in liver1.91.99.80.7-1.6-0.5-0.30.5-1.61.9-0.72.31.2-3.11.30.10.3-0.3
Mn content in liver5.35.812.5-0.7-2.21.0-1.92.1-2.12.9-2.23.32.9-3.53.3-2.5-1.71.7
Na content in liver1.01.03.2-0.2-1.3-1.1-1.00.9-1.80.5-1.00.70.5-1.3-0.3-0.11.4-1.4
Rb content in liver1.21.43.80.2-1.60.7-0.70.9-1.61.7-1.11.81.3-2.00.60.10.3-0.4
Se content in liver1.31.63.91.81.3-1.02.0-1.91.5-1.01.7-0.7-1.4-0.70.41.10.1-0.1
Sr content in liver1.21.12.50.20.5-0.61.1-1.11.0-1.11.2-0.7-1.21.3-1.61.50.7-0.8
Zn content in liver0.10.10.40.5-0.30.40.3-0.2-0.10.40.10.4-0.0-0.60.30.50.3-0.3
Bone: minimum diameter2.54.520.5-4.5-2.3-0.7-2.42.4-1.61.9-2.01.41.41.6-2.0-1.91.7-1.7
Time in familiar zone, hab. session 10.90.82.31.01.5-1.01.0-1.00.8-1.20.8-1.2-1.00.4-0.30.70.3-0.3
Time in novel zone, hab. session 10.20.20.8-0.5-0.90.8-0.30.3-0.20.6-0.10.70.30.1-0.10.1-0.20.1
Total zone transitions, hab. session 11.42.03.51.21.8-0.21.9-1.91.6-1.61.8-1.5-1.51.4-0.81.4-0.40.5
Total locomotion distance, hab. session 10.10.20.7-0.8-0.20.5-0.50.5-0.20.6-0.50.20.40.8-0.4-0.3-0.20.2
Locomotion velocity, hab. session 10.20.30.9-1.0-0.30.4-0.60.6-0.40.6-0.60.10.40.9-0.5-0.4-0.00.0
Time in familiar zone, hab. session 21.01.02.11.01.40.71.1-1.11.2-1.41.0-1.5-1.11.00.00.60.1-0.1
Time in novel zone, hab. session 21.01.12.3-0.9-1.50.2-1.21.2-1.01.5-1.11.51.2-0.80.2-0.6-0.60.5
Total zone transitions, hab. session 21.31.73.51.71.3-0.01.8-1.81.1-1.41.9-1.2-1.40.8-0.81.90.3-0.3
Total locomotion distance, hab. session 20.50.71.31.01.0-0.11.1-1.10.7-0.71.0-0.8-0.90.5-0.41.10.00.0
Locomotion velocity, hab. session 20.50.71.31.11.1-0.21.1-1.10.8-0.81.0-0.9-0.90.6-0.41.1-0.10.2
Novel to familiar place preference ratio0.40.51.3-1.1-0.70.1-1.01.0-0.60.7-0.90.40.70.10.0-0.9-0.20.2
Novelty place preference0.50.51.1-1.0-0.70.3-1.01.0-0.60.7-0.90.50.8-0.00.1-0.9-0.30.3
Time in novel zone, NPP test0.50.50.9-0.9-0.70.5-0.90.9-0.50.8-0.80.60.8-0.10.4-0.9-0.60.6
Total zone transitions, NPP test0.40.62.51.61.1-0.30.9-0.90.7-1.00.7-0.6-0.4-0.10.10.8-0.70.7
Total locomotion distance, NPP test0.10.10.40.30.00.2-0.10.1-0.10.2-0.20.20.4-0.10.3-0.2-0.60.6
Locomotion velocity, NPP test0.00.00.10.30.3-0.30.1-0.10.1-0.10.0-0.20.00.2-0.20.1-0.20.2
Intraocular pressure0.40.61.00.30.5-0.70.8-0.80.8-0.80.9-0.8-1.00.7-0.90.71.0-1.0
Delta distance traveled before/after self-admin0.20.20.60.70.8-0.30.5-0.50.5-0.40.4-0.4-0.30.10.20.0-0.40.5
Delta ambulatory time before/after self-admin0.40.51.40.61.20.20.6-0.60.9-0.80.5-0.8-0.50.60.3-0.3-0.70.8
Parametrial fat weight0.61.43.9-0.6-0.92.0-1.21.2-0.51.0-1.21.01.4-0.41.3-1.5-1.11.0
Pavlov. Cond. lever latency1.41.75.42.31.6-1.81.6-1.50.8-1.31.3-1.1-1.2-0.80.41.2-0.70.7
Pavlov. Cond. magazine entry latency4.15.38.7-2.4-2.72.4-2.92.9-2.52.7-2.82.42.8-0.91.1-2.6-0.20.2
Pavlov. Cond. change in total contacts1.92.04.0-1.9-2.00.7-1.61.6-1.61.9-1.31.81.5-0.70.1-1.40.9-0.9
Pavlov. Cond. index score2.73.46.0-2.4-2.21.7-2.52.4-1.82.2-2.21.82.1-0.30.4-2.10.3-0.3
Pavlov. Cond. latency score2.22.85.6-2.4-2.02.0-2.22.1-1.52.0-1.91.61.90.00.3-1.80.3-0.3
Pavlov. Cond. lever contacts1.41.74.9-2.2-1.71.6-1.61.6-1.01.4-1.31.11.20.6-0.4-1.20.9-0.8
Pavlov. Cond. magazine entry number5.06.310.12.22.9-1.93.2-3.22.9-3.13.1-2.7-3.11.6-1.62.80.5-0.5
Pavlov. Cond. intertrial magazine entries0.70.84.10.00.8-2.00.7-0.70.4-0.60.7-0.9-1.00.3-0.90.41.2-1.1
Pavlov. Cond. lever-magazine prob. diff.3.13.96.9-2.6-2.41.7-2.62.6-2.02.4-2.32.02.2-0.30.3-2.10.4-0.4
Pavlov. Cond. response bias5.36.511.1-2.8-3.12.2-3.33.3-2.83.1-3.12.73.0-1.01.0-2.8-0.10.1
Pavlov. Cond. lever latency0.60.81.70.81.3-0.11.0-1.01.3-1.31.0-1.1-0.90.6-0.10.5-0.50.5
Pavlov. Cond. magazine entry latency0.40.51.20.90.7-0.60.8-0.80.4-0.80.6-0.8-0.80.2-0.51.10.3-0.3
Pavlov. Cond. change in total contacts0.91.54.3-0.8-1.8-0.3-0.80.8-2.01.0-0.81.10.6-0.5-1.00.32.1-2.1
Pavlov. Cond. index score0.30.41.0-0.4-0.9-0.5-0.30.4-1.00.7-0.40.50.3-0.2-0.70.31.0-1.0
Pavlov. Cond. latency score0.30.40.9-0.5-0.9-0.5-0.40.4-0.90.6-0.40.50.2-0.1-0.70.20.9-1.0
Pavlov. Cond. lever contacts0.60.81.8-0.7-1.30.2-1.01.0-1.31.4-1.01.21.0-0.80.3-0.60.4-0.4
Pavlov. Cond. magazine entry number0.10.20.9-0.9-0.30.1-0.40.40.10.3-0.10.30.30.3-0.0-0.80.3-0.2
Pavlov. Cond. intertrial magazine entries1.11.76.7-2.6-1.4-0.3-1.41.3-0.71.3-0.81.11.10.5-0.9-1.71.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.8-0.3-0.7-0.5-0.20.2-0.80.5-0.20.40.1-0.1-0.70.50.9-0.9
Pavlov. Cond. response bias0.40.51.3-0.3-1.00.2-0.80.8-1.11.0-0.80.90.9-0.90.4-0.40.1-0.1
Time in closed arm before self-admin0.81.04.40.60.21.2-0.10.2-0.20.7-0.50.60.7-1.52.1-0.7-1.61.6
Time in closed arm after self-admin3.43.610.43.12.40.91.4-1.41.7-1.11.1-1.2-0.5-0.92.5-0.1-3.23.2
Time in open arm before self-admin2.83.18.50.61.60.61.7-1.72.0-1.91.8-2.0-2.12.9-2.12.10.5-0.6
Time in open arm after self-admin2.42.69.1-1.7-0.4-1.60.3-0.4-0.0-0.60.7-0.6-1.11.9-2.81.13.0-3.0
Bone: periosteal estimation2.14.515.3-3.9-2.4-1.0-2.82.8-2.02.2-2.51.71.70.8-1.3-2.10.9-0.9
Bone: periosteal perimeter1.32.210.1-3.2-1.6-0.7-1.81.7-1.01.1-1.40.70.71.4-1.6-1.11.2-1.2
Bone: post-yield work1.01.48.0-1.50.4-0.10.1-0.20.9-0.90.4-1.1-1.02.8-2.20.50.9-0.9
Progressive ratio test 1 active lever presses0.91.15.3-1.5-0.8-2.3-0.30.3-0.70.3-0.1-0.0-0.20.4-1.40.21.6-1.6
Progressive ratio test 1 breakpoint0.91.15.6-1.7-0.8-2.4-0.40.4-0.70.3-0.1-0.0-0.10.4-1.3-0.11.6-1.6
Progressive ratio test 1 inactive lever presses1.11.65.8-2.4-1.4-1.6-1.21.1-0.91.2-0.91.00.7-0.2-0.3-1.41.3-1.3
Progressive ratio test 2 active lever presses0.91.13.4-1.4-0.8-1.9-0.40.4-0.70.3-0.20.1-0.10.7-1.60.11.8-1.8
Progressive ratio test 2 breakpoint1.01.23.7-1.5-0.8-1.9-0.50.5-0.80.3-0.20.1-0.00.7-1.70.11.8-1.8
Progressive ratio test 2 inactive lever presses0.60.94.4-2.0-0.5-2.1-0.30.3-0.10.3-0.10.1-0.10.4-0.8-0.71.4-1.4
Incentive Sensitization - Responses0.91.34.1-1.1-1.2-0.6-0.80.8-1.00.5-0.70.50.30.9-2.00.41.9-2.0
Incentive Sensitization - Breakpoint1.01.34.2-1.0-1.2-0.7-0.80.8-1.00.5-0.60.40.30.9-2.00.51.9-2.0
Sum of active levers in priming session hrs 5-61.51.45.70.4-0.5-2.40.0-0.0-0.9-0.1-0.0-0.2-0.5-0.5-1.51.42.2-2.2
Progressive ratio0.20.31.10.0-0.3-1.1-0.70.7-0.90.4-0.70.30.7-0.80.1-0.60.1-0.0
Food seeking constrained by brief footshock0.30.41.80.00.1-1.00.2-0.2-0.1-0.30.3-0.2-0.20.4-1.00.21.3-1.3
Seeking ratio, punishment vs. effort0.30.41.4-0.4-0.1-0.20.5-0.50.3-0.40.5-0.2-0.60.8-0.80.51.2-1.2
Retroperitoneal fat weight0.10.55.4-0.4-0.12.3-0.20.20.20.7-0.20.20.40.70.2-0.1-0.40.4
Reaction time number correct0.10.10.4-0.40.3-0.10.3-0.30.6-0.10.5-0.1-0.50.4-0.10.20.1-0.1
Reaction time mean minus median0.10.30.7-0.4-0.7-0.8-0.20.2-0.50.6-0.00.80.4-0.70.0-0.50.8-0.8
Reaction time mean minus median AUC0.40.93.4-0.1-1.1-0.9-0.60.7-1.11.2-0.61.51.0-1.81.0-0.90.0-0.0
Reaction time num false alarms0.20.20.9-0.80.1-0.90.0-0.10.4-0.60.4-0.2-0.30.6-0.4-0.60.1-0.1
Reaction time num false alarms AUC0.10.20.9-0.9-0.1-0.7-0.30.20.3-0.20.20.10.10.4-0.2-1.00.0-0.0
Reaction time trials correct on left0.10.10.4-0.40.3-0.10.3-0.30.6-0.10.5-0.1-0.50.4-0.10.20.1-0.1
Reaction time trials on left0.00.10.3-0.50.1-0.10.2-0.20.50.10.40.1-0.40.3-0.10.10.1-0.1
Reaction time mean0.91.43.0-0.5-1.7-0.5-0.90.9-1.71.4-0.91.61.2-1.70.4-0.61.0-1.0
Reaction time mean AUC0.81.33.6-0.3-1.5-1.0-0.70.8-1.71.3-0.91.51.1-1.90.4-0.51.1-1.1
Median of all reaction times1.11.53.3-0.7-1.8-0.4-1.01.0-1.81.4-1.11.71.2-1.70.3-0.61.1-1.1
Reaction time omissions3.85.510.9-1.9-3.30.1-2.82.8-3.12.9-2.63.22.8-2.00.7-2.00.6-0.6
Reaction time false alarm rate0.10.20.8-0.6-0.2-0.9-0.30.30.0-0.2-0.00.00.20.1-0.2-0.90.1-0.0
Reaction time premature initiation rate0.30.41.5-0.5-0.50.8-0.80.8-0.30.2-0.70.30.70.10.5-1.2-0.40.5
Reaction time premature initiations0.20.31.6-0.7-0.40.5-0.80.7-0.20.2-0.50.30.50.20.4-1.3-0.40.4
Std. dev. reaction times0.61.23.5-0.2-1.4-0.6-0.80.8-1.41.4-0.71.71.3-1.90.7-0.90.5-0.5
Reaction time trials completed0.00.10.3-0.50.1-0.10.2-0.20.50.10.40.1-0.40.3-0.10.10.1-0.1
Reaction time trials AUC0.00.10.2-0.40.1-0.20.2-0.20.40.00.40.1-0.40.3-0.10.10.1-0.1
Run reversals in cocaine runway, females1.31.33.70.71.20.31.2-1.31.9-1.21.4-1.1-1.31.5-1.00.90.0-0.1
Run reversals in cocaine runway, males0.50.52.0-0.9-0.61.4-0.80.8-0.10.4-0.80.50.80.40.3-0.9-0.60.6
Latency to leave start box in cocaine runway0.80.91.90.71.21.00.9-0.91.3-1.31.0-1.4-0.91.2-0.20.6-0.50.4
Latency to leave start box in cocaine runway, F3.33.87.41.02.30.01.9-2.02.7-2.62.1-2.7-2.32.5-1.51.80.0-0.1
Latency to leave start box in cocaine runway, M2.11.93.3-0.3-1.31.5-1.31.4-1.81.5-1.41.61.8-1.71.7-1.3-0.60.7
Std. dev. time between licks in bursts0.60.81.30.20.9-0.40.8-0.80.8-1.00.7-1.1-1.21.1-1.11.10.8-0.8
Total sessions with >9 infusions1.92.34.8-0.60.8-2.21.4-1.40.9-1.51.5-1.6-2.01.6-1.81.71.6-1.6
Short access day 1 total inactive lever presses0.40.62.1-1.4-1.00.7-0.50.5-0.50.3-0.40.40.11.1-0.90.30.9-1.0
Short access day 10 total inactive lever presses0.41.04.0-2.0-1.1-1.0-1.01.0-0.51.0-0.81.10.8-0.1-0.2-1.30.7-0.7
Short access day 1 total infusions0.60.86.0-1.5-0.6-2.4-0.30.3-0.50.2-0.40.1-0.2-0.5-0.1-0.11.0-1.0
Short access day 10 total infusions0.50.62.0-1.1-0.1-1.40.2-0.30.1-0.30.4-0.6-0.70.8-1.00.41.2-1.2
Short access total infusions0.50.73.4-1.4-0.3-1.90.2-0.2-0.0-0.20.2-0.3-0.70.4-0.70.31.3-1.3
Short access day 1 locomotion0.60.72.8-1.7-0.8-1.6-0.40.3-0.70.1-0.30.0-0.20.7-1.00.11.0-1.0
Short access day 10 total locomotion0.50.93.5-1.9-0.8-0.3-0.50.5-0.60.4-0.10.30.31.4-1.3-0.71.6-1.5
Short access total locomotion1.41.74.5-2.1-0.3-1.60.3-0.30.1-0.40.7-0.6-0.92.1-2.10.32.0-1.9
One hour access (0.3 mA shock)0.40.51.8-0.00.4-1.30.1-0.20.1-0.60.3-0.8-0.50.9-1.30.60.7-0.7
Compulsive drug intake0.30.44.10.7-0.12.0-0.10.1-0.10.0-0.20.30.30.20.10.4-0.50.5
One hour access (shock baseline)0.91.34.0-0.50.7-2.00.7-0.80.6-1.01.0-1.2-1.11.4-1.80.81.3-1.3
Social response proportion1.71.95.7-0.50.71.21.6-1.62.0-1.31.9-0.8-1.52.4-1.21.00.7-0.7
Social responses0.10.21.0-0.7-0.21.0-0.10.10.30.10.10.10.10.60.3-0.6-0.40.4
Social time0.91.23.6-1.9-0.50.70.6-0.60.8-0.00.80.1-0.81.6-1.40.41.9-1.9
Soleus weight0.41.22.9-0.20.8-0.21.1-1.11.5-0.81.3-0.8-1.31.7-1.51.10.8-0.9
Bone: stiffness0.10.20.80.10.4-0.6-0.40.4-0.1-0.2-0.5-0.40.20.20.2-0.6-0.90.9
Tibialis anterior weight0.72.44.5-0.11.2-0.61.7-1.71.5-1.21.9-1.4-1.92.1-2.01.71.6-1.6
Time to tail flick, vehicle, before self-admin0.30.31.81.30.10.40.00.00.10.1-0.10.10.3-0.70.40.4-0.80.7
Time to tail flick, vehicle, after self-admin0.40.51.3-0.7-0.8-0.1-0.90.8-0.90.7-0.80.70.9-0.70.7-1.1-0.00.1
Time to tail flick, test, before self-admin1.31.43.81.00.8-0.41.6-1.51.0-0.81.4-0.6-1.40.7-1.21.91.1-1.2
Time to tail flick, test, after self-admin0.10.10.80.0-0.1-0.90.1-0.10.10.20.10.3-0.1-0.4-0.10.00.6-0.6
Delta time to tail flick, vehicle, before/after SA1.01.03.5-1.9-1.2-0.4-1.11.1-1.01.0-0.90.90.9-0.1-0.2-1.20.8-0.7
Delta time to tail flick, test, before/after SA0.90.91.7-1.3-1.3-0.2-1.31.2-1.21.0-1.11.00.9-0.4-0.0-0.90.5-0.5
Tibia length1.12.99.50.71.72.70.6-0.72.1-0.50.7-1.0-0.20.92.2-1.0-3.13.1
Ambulatory time before self-admin0.50.81.8-1.0-1.1-1.3-0.90.9-1.30.7-0.80.70.7-0.7-0.3-0.30.7-0.8
Ambulatory time after self-admin0.10.10.3-0.4-0.2-0.3-0.40.4-0.50.2-0.50.10.4-0.10.2-0.5-0.20.2
Bone: tissue strength1.11.13.31.21.40.90.5-0.51.2-1.00.2-0.9-0.2-0.21.5-0.5-1.81.8
Total heroin consumption1.72.04.0-1.4-2.0-0.9-1.61.6-2.01.4-1.61.41.1-0.9-0.7-0.31.7-1.7
Bone: trabecular number3.25.48.0-2.5-2.72.5-2.82.8-2.02.6-2.62.52.8-0.91.6-2.8-0.90.9
Bone: trabecular spacing1.92.64.71.51.9-1.51.9-1.91.4-2.21.9-2.0-1.80.9-1.31.60.9-0.8
Bone: trabecular thickness0.60.72.3-1.5-1.00.9-1.01.0-0.30.8-0.80.70.70.60.3-1.1-0.80.8
Bone: trabecular tissue density0.50.72.10.70.10.9-0.40.50.10.1-0.60.20.7-0.91.4-0.7-1.41.4
Water consumed over 24 hours0.50.71.80.60.60.50.6-0.61.2-0.10.90.1-0.0-0.31.3-0.5-1.31.3
Number of responses in last shaping day0.40.42.6-1.6-0.1-0.8-0.30.20.6-0.4-0.0-0.4-0.31.1-0.6-0.70.2-0.3