Hub : Genes

Fmnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr10_88127885_88130364 0.04 0.02 7.5e-04 0.03 0.03 0.03 0.03 7.4e-04 5.2e-04 6.5e-04 1.1e-03
2 PL mRNA stability Fmnl1 0.04 0.02 1.8e-04 0.02 0.03 0.03 0.01 2.5e-03 2.2e-04 3.1e-04 7.3e-03
3 NAcc mRNA stability Fmnl1 0.03 0.02 4.1e-03 0.02 0.02 0.02 0.02 1.9e-03 2.6e-03 2.2e-03 1.8e-03
4 BLA alternative TSS XM_006247498.4 0.18 0.1 7.9e-03 0.02 0.02 0.03 0.02 2.1e-02 3.9e-02 1.5e-02 1.9e-02
5 PL isoform ratio XM_006247499.4 0.04 0.03 2.6e-03 0.03 0.01 0.02 0.02 1.4e-04 1.4e-02 3.5e-03 2.9e-03
6 PL isoform ratio NM_001105846.1 0.03 0.02 7.5e-03 0.03 0 0.01 0.01 6.0e-04 7.9e-02 4.7e-02 1.7e-02
7 NAcc gene expression Fmnl1 0.02 0.02 5.2e-03 0.01 0.01 0 0.01 1.5e-02 2.4e-02 3.1e-01 4.1e-02
8 BLA alternative TSS NM_001105846.1 0.18 0.1 6.4e-03 0.02 0.02 0.03 0.03 3.0e-02 2.9e-02 1.1e-02 1.7e-02
9 PL gene expression Fmnl1 0.07 0.03 6.4e-07 0.06 0.06 0.04 0.06 3.4e-07 1.1e-06 2.2e-05 5.0e-07
10 NAcc intron excision ratio chr10_88125960_88126586 0.02 0.02 8.7e-03 0.01 0.01 0.01 0.01 6.6e-03 6.9e-03 6.2e-03 8.7e-03
11 Liver gene expression Fmnl1 0.03 0.02 1.8e-03 0.02 0.01 0.02 0.01 3.4e-03 1.6e-02 4.9e-03 1.4e-02
12 Brain gene expression Fmnl1 0.09 0.04 1.2e-05 0.03 0.07 0.05 0.06 1.3e-03 9.3e-07 2.8e-05 8.1e-06
13 Adipose gene expression Fmnl1 0.22 0.08 0.0e+00 0.18 0.16 0.18 0.18 6.7e-20 8.2e-18 3.5e-19 2.9e-19
14 Adipose mRNA stability Fmnl1 0.1 0.04 3.1e-11 0.07 0.08 0.07 0.07 1.9e-08 2.1e-09 3.8e-08 9.6e-09
15 NAcc intron excision ratio chr10_88125930_88126586 0.02 0.02 8.7e-03 0.02 0.01 0.01 0.01 5.3e-03 6.5e-03 5.9e-03 7.1e-03
16 Brain mRNA stability Fmnl1 0.14 0.07 2.0e-05 0.03 0.05 0.03 0.03 6.6e-04 1.6e-05 9.6e-04 6.1e-04
17 Adipose alternative polyA XM_006247498.4 0.06 0.03 1.1e-03 0 0.01 0.01 0.01 1.2e-01 8.7e-03 7.8e-03 1.5e-02
18 Adipose alternative polyA XM_039085630.1 0.05 0.03 1.9e-03 0.01 0.02 0.02 0.01 1.3e-02 3.4e-03 4.7e-03 8.1e-03
19 Adipose alternative polyA XM_039085630.1 0.05 0.03 1.3e-03 0.01 0.02 0.02 0.02 5.8e-02 1.7e-03 3.6e-03 4.7e-03
20 NAcc isoform ratio XM_006247499.4 0.15 0.09 5.5e-03 0 0.01 0 -0 2.7e-01 7.3e-03 7.9e-02 8.8e-01
21 Adipose alternative polyA XM_006247498.4 0.05 0.03 1.6e-03 0 0.01 0.01 0.01 1.0e-01 2.8e-02 3.5e-02 3.5e-02
22 OFC gene expression Fmnl1 0.26 0.12 1.8e-03 0.06 0.1 0.06 0.04 1.8e-02 2.9e-03 1.6e-02 3.3e-02
23 RMTg gene expression Fmnl1 0.22 0.13 7.9e-03 0.03 0.04 0.04 0.03 5.8e-02 2.9e-02 3.0e-02 5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density1.72.86.9-2.6-2.5-2.1-0.40.2-0.22.40.12.31.0-2.3-2.6-2.32.4-0.7-1.4-0.9-0.8-0.8-1.21.2-1.61.0
Area under the delay curve0.30.31.00.20.30.0-1.00.5-0.5-0.21.0-0.2-0.10.30.70.5-0.7-0.10.30.50.70.70.3-0.70.8-0.6
BMI with tail1.23.811.21.52.51.52.41.6-1.6-2.5-2.2-2.81.52.81.03.1-2.4-1.33.3-0.8-0.1-0.12.70.30.3-1.0
BMI without tail0.81.710.60.30.70.73.30.6-0.6-0.4-3.1-0.51.40.8-1.10.7-0.1-1.10.5-0.9-0.7-0.62.51.0-0.60.6
Body weight1.04.413.6-0.90.1-1.12.93.7-3.7-1.6-2.8-1.33.41.7-0.41.8-1.5-3.53.10.00.60.61.7-0.20.6-2.1
Weight adjusted by age1.11.36.70.10.2-0.3-2.60.7-0.7-0.32.5-0.3-0.10.21.50.2-0.90.30.61.41.41.4-0.5-1.61.4-1.0
Bone surface2.64.715.1-3.9-3.4-3.7-1.71.7-1.72.91.42.92.0-2.8-2.6-2.72.2-1.6-1.30.50.90.8-1.4-0.3-0.3-0.2
Bone volume2.03.511.0-3.3-3.0-2.9-1.21.1-1.12.70.92.71.6-2.6-2.6-2.42.3-1.0-1.3-0.20.10.1-0.80.4-0.80.5
Breakpoint value in progressive ratio session0.60.72.3-0.7-0.9-1.0-0.90.6-0.60.71.00.60.6-0.70.2-0.60.1-0.2-0.81.51.21.2-0.4-1.21.1-0.7
Number of licking bursts1.41.75.00.80.8-0.20.61.3-1.3-2.0-0.4-1.80.41.01.51.3-1.9-1.61.51.01.01.0-1.2-1.21.3-2.2
Context. condit. distance diff. score1.21.53.71.71.81.80.5-0.40.4-1.7-0.4-1.9-0.41.91.51.9-1.40.81.9-0.3-0.4-0.41.00.10.1-0.2
Locomotion velocity, session 10.40.41.2-0.4-0.5-0.10.3-0.70.70.6-0.30.70.1-0.7-0.7-0.61.01.0-0.3-0.4-0.6-0.60.60.7-0.81.1
Locomotion distance, session 10.30.41.2-0.1-0.00.30.6-0.80.80.7-0.60.20.1-0.1-0.7-0.20.70.8-0.3-0.6-0.5-0.51.10.7-0.71.1
Locomotion velocity, session 21.21.44.3-0.2-0.40.5-0.3-2.12.11.20.20.9-1.2-1.1-0.6-1.11.52.0-0.9-0.6-1.0-1.1-0.11.0-1.31.9
Locomotion distance, session 20.50.61.7-0.4-0.30.31.1-1.21.21.0-1.00.8-0.4-0.7-0.8-0.71.00.8-0.8-0.3-0.4-0.50.50.6-0.81.3
Locomotion velocity, session 30.20.31.3-0.2-0.0-0.10.1-0.10.10.3-0.3-0.10.30.1-0.5-0.00.30.40.4-1.1-0.9-0.9-0.11.0-0.90.5
Locomotion distance, session 30.30.31.30.20.40.1-1.10.5-0.5-0.51.0-1.00.00.80.60.5-0.7-0.10.9-0.20.10.1-0.4-0.20.2-0.6
Stereotopy head waving bouts, day 31.21.44.30.30.20.60.5-1.21.20.9-0.70.9-0.9-0.4-1.1-0.21.01.5-0.9-2.1-1.8-1.80.71.9-1.61.8
Stereotopy head waving duration, day 30.60.71.80.60.50.80.4-1.21.20.6-0.50.7-0.6-0.2-0.40.10.41.3-0.7-1.2-1.1-1.10.61.1-0.91.2
Locomotion velocity, session 71.01.12.91.11.01.41.6-0.80.8-0.8-1.7-0.3-0.30.8-0.00.7-0.10.90.7-1.4-1.6-1.60.51.4-1.20.9
Locomotion distance, session 70.30.41.50.90.91.20.0-0.70.7-0.5-0.1-0.4-0.40.70.60.6-0.30.90.8-0.3-0.6-0.60.30.4-0.50.5
Stereotopy head waving bouts, day 70.91.07.6-0.4-0.6-0.8-1.0-0.60.60.50.71.8-0.6-1.6-0.5-1.40.80.2-1.1-0.6-0.6-0.5-2.80.5-0.80.1
Stereotopy head waving duration, day 70.81.05.50.4-0.00.1-0.1-1.41.40.1-0.11.3-1.3-1.3-0.3-1.10.70.7-1.3-0.9-1.1-1.0-2.30.9-1.00.6
Locomotion velocity, session 81.21.47.70.40.80.82.80.1-0.1-0.4-2.6-1.11.31.2-0.61.0-0.2-0.11.0-0.9-0.6-0.72.50.9-0.60.7
Locomotion distance, session 80.60.92.61.01.11.61.1-1.41.4-0.3-1.0-0.7-0.90.80.40.7-0.11.50.4-0.5-0.7-0.71.20.6-0.61.1
Degree of sensitization distance0.20.21.20.30.40.61.1-0.00.0-0.2-0.9-0.10.30.40.30.6-0.30.20.80.40.10.11.1-0.10.10.1
Degree of sensitization stereotypy0.60.77.60.0-0.3-0.4-0.6-0.70.7-0.20.41.3-0.9-1.20.2-1.00.30.1-0.5-0.2-0.4-0.4-2.80.2-0.5-0.2
Conditioned locomotion0.10.10.30.0-0.00.00.50.1-0.10.1-0.4-0.0-0.6-0.0-0.00.10.0-0.20.2-0.5-0.4-0.4-0.30.3-0.3-0.0
Cocaine response after cond. corrected0.20.31.4-0.3-0.1-0.1-0.10.2-0.2-0.30.1-0.1-0.6-0.0-0.00.1-0.0-0.41.2-0.9-0.7-0.7-1.00.6-0.8-0.2
Cocaine response after cond. not corrected0.60.72.9-0.8-0.8-0.5-0.2-0.20.20.30.00.7-0.6-0.9-0.6-0.90.8-0.20.7-1.0-1.1-1.1-1.71.0-1.40.3
Cocaine response before conditioning0.60.72.2-0.7-0.9-0.5-0.0-0.80.81.0-0.11.50.2-1.4-1.0-1.51.30.4-1.1-0.1-0.4-0.5-0.60.5-0.81.0
Saline control response0.20.31.3-0.2-0.2-0.31.00.7-0.70.4-0.90.20.80.4-0.40.3-0.1-1.1-0.50.40.50.50.8-0.30.6-0.4
Bone: connectivity density2.13.28.8-3.0-2.9-2.7-1.30.3-0.32.51.02.50.9-2.7-2.2-2.82.4-0.5-1.60.00.10.0-1.90.3-0.90.5
Bone: cortical apparent density3.54.614.51.81.12.31.3-3.83.80.5-1.30.3-3.4-0.6-0.6-0.61.32.4-2.3-2.3-2.6-2.6-0.62.3-2.32.8
Bone: cortical area1.52.26.9-2.6-2.2-2.1-0.90.8-0.82.20.52.21.1-2.0-2.4-1.81.9-1.0-1.2-0.6-0.1-0.1-0.70.7-1.00.5
Bone: cortical porosity4.65.116.8-4.1-3.5-3.9-1.23.1-3.12.11.11.93.4-1.7-2.0-1.71.3-2.70.11.51.91.80.2-1.20.8-1.2
Bone: cortical porosity3.13.411.3-3.4-2.7-3.1-0.82.8-2.81.50.61.33.2-1.1-1.7-1.00.9-2.50.71.01.41.30.4-0.80.5-1.1
Bone: cortical thickness1.83.08.8-0.6-0.60.00.6-1.51.51.0-1.01.4-1.1-1.5-2.0-1.41.90.6-1.0-2.8-2.6-2.6-1.82.7-3.01.8
Bone: cortical thickness2.73.110.6-0.9-1.3-0.6-1.8-1.71.71.41.32.1-1.8-2.2-1.1-2.22.01.7-1.3-1.6-1.8-1.8-3.31.6-2.21.4
Bone: cortical tissue density3.34.314.31.81.12.31.1-3.83.80.5-1.10.4-3.3-0.7-0.5-0.61.32.4-2.3-2.2-2.5-2.4-0.62.2-2.22.8
Condit. Reinf. active minus inactive responses1.11.23.8-1.0-1.1-1.1-1.70.6-0.60.61.80.80.2-0.70.5-0.60.0-0.3-0.42.01.71.7-0.5-1.71.5-1.0
Condit. Reinf. active-inactive response ratio1.31.46.7-0.2-0.3-0.3-2.50.1-0.10.12.60.2-0.3-0.21.3-0.2-0.40.60.01.91.61.6-0.8-1.81.4-0.9
Condit. Reinf. active responses0.60.81.7-1.2-1.3-0.9-0.70.4-0.41.30.91.30.5-1.0-0.4-0.80.7-0.3-0.91.21.11.10.2-0.90.7-0.2
Condit. Reinf. inactive responses1.31.64.7-1.1-1.0-0.51.7-0.10.11.8-1.71.40.7-1.1-2.2-0.91.6-0.4-1.2-1.3-1.1-1.11.01.5-1.41.4
Incentive salience index mean1.01.23.2-1.2-1.4-1.2-1.30.5-0.51.01.51.30.2-1.1-0.0-1.10.5-0.4-0.91.81.51.5-0.7-1.41.1-0.6
Condit. Reinf. lever presses0.20.31.2-0.5-0.6-0.20.6-0.30.30.9-0.51.10.1-0.8-0.7-0.70.7-0.3-0.90.40.20.20.4-0.0-0.10.6
Condit. Reinf. active minus inactive responses2.63.28.7-2.7-2.7-2.4-2.50.5-0.52.72.32.91.3-2.5-1.2-2.21.8-0.0-1.31.31.01.0-1.2-0.80.20.1
Condit. Reinf. active-inactive response ratio3.03.18.3-2.3-2.4-2.4-2.90.9-0.91.82.72.51.2-2.2-0.5-1.91.1-0.7-1.11.91.71.7-1.5-1.61.0-0.6
Condit. Reinf. active responses2.63.710.4-2.8-2.9-2.5-2.40.3-0.33.02.23.21.2-2.7-1.3-2.62.10.3-1.81.51.11.1-1.0-0.90.20.4
Condit. Reinf. inactive responses0.91.23.3-1.0-1.3-0.50.5-0.90.91.8-0.51.60.0-1.3-1.4-1.41.70.9-1.6-0.2-0.5-0.50.40.7-0.81.5
Condit. Reinf. lever presses1.01.44.5-1.6-1.8-1.3-1.7-0.10.11.91.52.10.3-1.7-0.7-1.51.40.7-1.20.80.60.5-0.7-0.40.00.4
Condit. Reinf. lever reinforcers received2.23.18.9-2.6-2.7-2.2-2.50.2-0.22.92.23.00.9-2.5-1.3-2.42.00.4-1.71.20.90.8-0.9-0.60.10.4
Conditioned reinforcement - actives0.50.51.6-0.3-0.3-0.70.00.8-0.8-0.30.0-0.41.0-0.10.40.2-0.5-0.70.21.31.01.0-0.2-1.01.0-1.1
Conditioned reinforcement - inactives1.01.12.9-1.7-1.6-1.50.20.3-0.31.5-0.21.51.2-1.6-1.7-1.41.3-1.0-1.3-0.10.10.1-0.30.3-0.40.3
Conditioned locomotion0.60.82.3-0.9-0.8-1.1-0.61.5-1.5-0.00.7-0.00.7-0.20.20.1-0.4-0.90.71.11.11.10.2-1.01.0-1.2
Patch foraging indifference point 0 sec1.82.96.8-1.7-1.8-0.81.8-0.60.62.4-1.82.20.1-1.8-2.6-1.72.50.3-1.4-1.6-1.6-1.70.32.0-2.11.9
Patch foraging indifference point AUC0.40.51.7-0.6-0.5-0.80.10.6-0.6-0.10.0-0.30.40.20.50.2-0.4-0.60.61.31.01.0-0.8-1.10.7-1.2
Delay disc. indifference point, 0s delay0.30.41.30.40.30.3-1.1-0.30.30.01.10.0-0.90.21.00.2-0.41.00.10.80.50.5-0.1-0.70.6-0.2
Delay disc. indifference point, 16s delay0.80.81.70.60.90.4-1.30.7-0.7-1.11.3-1.1-0.01.11.11.3-1.3-0.11.30.20.60.60.6-0.70.9-0.9
Delay disc. indifference point, 2s delay0.80.92.9-1.4-1.4-1.2-1.00.1-0.11.71.01.70.2-1.1-0.8-1.11.10.1-1.10.80.60.60.2-0.40.20.5
Delay disc. indifference point, 24s delay0.50.51.2-0.2-0.2-0.6-1.10.8-0.8-0.21.1-0.20.50.10.70.2-0.5-0.30.51.11.00.9-0.4-1.00.9-1.0
Delay disc. indifference point, 4s delay0.50.54.10.40.30.4-2.0-0.00.00.01.9-0.0-0.60.40.80.5-0.40.60.10.30.40.40.3-0.50.6-0.1
Delay disc. indifference point, 8s delay0.10.10.40.30.10.3-0.2-0.40.40.30.20.4-0.5-0.3-0.1-0.10.20.3-0.6-0.5-0.3-0.20.00.2-0.10.4
Indifference point function ln k0.71.02.8-1.2-1.2-1.0-0.80.1-0.11.30.61.4-0.2-1.7-1.4-1.61.4-0.1-1.2-0.8-0.5-0.5-0.30.7-0.80.9
Indifference point function log k0.71.02.8-1.2-1.2-1.0-0.80.1-0.11.30.61.4-0.2-1.7-1.4-1.61.4-0.1-1.2-0.8-0.5-0.5-0.30.7-0.80.9
Patch foraging total patch changes 0 sec2.03.28.4-2.0-2.0-1.01.8-0.30.32.5-1.92.30.4-1.9-2.9-1.72.6-0.0-1.4-1.7-1.6-1.60.42.1-2.21.9
Patch foraging total patch changes 12 sec1.31.75.1-1.7-1.7-0.81.4-0.60.62.2-1.41.60.6-1.3-2.0-1.42.00.0-1.6-0.4-0.6-0.60.20.9-1.21.4
Patch foraging total patch changes 18 sec0.20.21.1-1.0-0.8-0.6-0.20.3-0.31.00.10.80.1-0.4-0.6-0.30.60.00.1-0.1-0.1-0.10.00.2-0.40.2
Patch foraging total patch changes 24 sec1.72.15.8-1.8-1.8-1.10.9-0.00.02.4-1.01.70.6-1.5-2.4-1.42.1-0.2-1.4-1.3-1.2-1.2-0.01.6-1.71.4
Patch foraging total patch changes 6 sec0.50.81.8-1.2-1.2-0.61.3-0.40.41.2-1.20.8-0.2-0.7-1.3-0.81.2-0.2-0.4-0.8-0.8-0.8-0.21.0-1.10.6
Patch foraging time to switch 0 sec0.10.20.70.40.30.6-0.4-0.60.6-0.00.5-0.10.10.20.50.3-0.00.90.10.40.20.10.4-0.30.20.3
Patch foraging water rate 0 sec0.20.31.0-0.30.0-0.00.90.4-0.40.1-1.00.10.2-0.0-0.7-0.00.1-0.50.4-1.0-0.6-0.60.60.8-0.60.2
Patch foraging water rate 12 sec0.40.53.40.30.40.1-1.40.1-0.1-0.61.2-0.4-1.8-0.00.50.0-0.30.50.9-1.0-0.6-0.6-1.10.4-0.4-0.2
Patch foraging water rate 18 sec1.72.46.6-0.3-0.30.41.1-1.01.01.2-1.31.2-0.9-1.3-1.7-1.11.61.0-0.6-2.6-2.5-2.5-0.32.5-2.62.0
Patch foraging water rate 24 sec0.81.22.80.50.41.10.0-1.41.40.5-0.20.6-1.3-0.6-0.5-0.50.81.7-0.5-1.6-1.5-1.50.61.5-1.41.7
Patch foraging water rate 6 sec0.40.51.4-1.2-1.1-1.1-0.80.6-0.60.70.60.90.0-1.1-0.9-1.20.8-0.4-0.2-0.4-0.1-0.2-0.80.3-0.40.1
Seeking ratio, delayed vs. immediate footshock1.82.04.00.10.5-0.1-0.51.8-1.8-1.10.6-1.11.31.21.61.4-1.7-0.91.82.01.91.91.2-1.92.0-1.8
Distance traveled before self-admin0.70.72.2-0.3-0.3-0.3-1.40.7-0.7-0.01.5-0.0-0.20.30.90.1-0.40.60.11.41.31.20.1-1.31.3-0.8
Distance traveled after self-admin0.60.61.60.50.70.7-0.80.3-0.3-0.50.9-0.4-0.70.91.30.8-0.90.91.00.81.00.90.8-1.01.0-0.5
Extensor digitorum longus weight2.911.527.04.34.63.40.61.3-1.3-5.0-0.1-4.7-0.55.15.05.2-5.20.14.41.71.61.72.4-2.33.1-2.9
Bone: elastic displacement0.40.54.2-0.8-0.9-1.0-0.60.1-0.10.20.40.6-0.2-0.8-0.5-1.00.6-0.2-0.1-0.5-0.5-0.5-2.00.4-0.7-0.2
Bone: elastic work1.01.23.8-2.0-1.9-1.9-0.60.6-0.61.20.41.40.4-1.6-1.4-1.51.3-0.9-0.5-0.3-0.3-0.3-1.60.5-0.7-0.1
Bone: endosteal estimation2.86.114.2-2.8-2.2-2.9-3.33.3-3.31.63.31.02.4-0.5-0.1-0.4-0.3-1.80.23.23.83.71.6-3.23.0-2.1
Bone: endosteal perimeter4.28.719.7-3.4-2.6-3.8-3.14.4-4.41.53.11.03.6-0.8-0.4-0.6-0.4-3.30.13.44.24.21.1-3.53.5-2.9
Epididymis fat weight0.40.85.4-0.30.1-0.70.61.5-1.5-0.8-0.7-0.51.80.5-0.50.6-0.7-2.30.30.10.60.70.6-0.30.6-1.0
Delta time in closed arm before/after self-admin3.13.014.61.21.51.73.8-0.30.3-1.3-3.8-1.30.31.4-1.01.4-0.4-1.10.7-2.4-1.8-1.82.12.1-1.40.7
Delta time in open arm before/after self-admin1.01.04.00.3-0.1-0.3-1.20.3-0.3-0.01.30.10.4-0.01.1-0.1-0.60.4-0.92.01.61.6-0.2-1.71.7-0.9
Diff in mean of infusions in LGA sessions0.40.41.1-0.5-0.5-0.70.31.0-1.0-0.1-0.2-0.10.7-0.10.1-0.1-0.3-0.70.11.11.01.0-0.1-0.90.9-0.9
Delay discount exponential model param0.30.30.8-0.0-0.10.20.9-0.70.70.1-0.90.1-0.2-0.3-0.6-0.50.60.4-0.3-0.7-0.8-0.8-0.40.8-0.90.7
Extinction: sum of active levers before priming0.30.32.50.20.10.31.60.4-0.4-0.3-1.4-0.40.30.5-0.00.5-0.3-0.10.00.1-0.00.00.90.10.2-0.2
Active lever presses in extinction session 62.22.14.8-1.5-1.4-2.0-0.72.2-2.20.40.70.31.8-0.50.1-0.3-0.4-1.70.12.02.12.1-0.5-1.91.7-1.9
Bone: final force1.72.77.7-2.2-2.0-1.30.6-0.60.62.3-0.82.00.2-1.9-2.8-2.02.50.0-1.5-1.6-1.4-1.4-0.61.8-2.11.7
Bone: final moment1.93.18.3-2.3-2.1-1.50.4-0.60.62.5-0.72.30.2-2.1-2.9-2.22.70.1-1.5-1.6-1.4-1.5-0.71.9-2.31.8
Food consumed during 24 hour testing period0.80.93.0-0.00.1-0.41.71.4-1.4-1.4-1.5-1.01.00.50.20.6-0.8-1.41.10.50.50.50.4-0.50.7-1.1
Glucose0.50.82.21.51.51.50.6-0.70.7-0.9-0.5-1.2-0.91.00.81.2-0.90.70.6-0.5-0.4-0.41.20.20.10.3
Heart weight2.23.211.9-0.40.1-1.20.33.4-3.4-1.4-0.3-1.42.71.40.41.3-1.8-3.31.70.81.31.4-0.1-1.21.6-2.6
Delay discount hyperbolic model param0.20.20.90.10.00.21.0-0.50.5-0.2-0.9-0.2-0.1-0.1-0.4-0.30.30.20.0-0.6-0.7-0.7-0.40.7-0.80.4
Intermittent access intake day 1-15 change0.80.87.30.20.60.81.0-0.40.40.2-1.00.21.00.4-0.90.60.3-0.2-0.0-0.9-0.6-0.72.71.0-0.61.3
Intermittent access intake escalation0.90.95.40.71.01.11.2-0.40.4-0.5-1.3-0.40.80.8-0.60.9-0.1-0.30.3-1.1-0.9-0.92.31.1-0.71.0
Intermittent access intake escalation 21.11.16.2-0.10.30.32.10.5-0.5-0.3-2.0-0.21.70.7-1.20.70.0-1.40.2-0.8-0.5-0.52.50.9-0.50.6
Intermitt. access day 1 inactive lever presses2.62.88.5-2.6-2.2-2.70.22.1-2.11.3-0.21.32.8-1.7-2.1-1.61.0-2.9-1.20.61.21.2-0.2-0.60.5-0.8
Intermitt. access day 15 inactive lever presses3.94.29.4-3.1-3.1-3.0-2.50.6-0.62.62.42.50.6-2.9-1.4-2.92.0-0.8-2.01.81.71.7-1.9-1.40.6-0.1
Intermitt. access escalation Index0.80.71.50.80.90.3-0.20.6-0.6-1.10.3-1.00.51.21.21.0-1.2-0.30.80.70.70.7-0.5-0.90.9-1.0
Intermittent access day 1 total infusions0.70.81.9-0.2-0.1-0.5-1.11.2-1.2-0.61.2-0.50.60.20.90.5-0.9-0.60.81.21.21.2-0.1-1.21.3-1.4
Intermittent access day 15 total infusions0.50.64.90.50.80.70.70.4-0.4-0.8-0.6-0.71.00.90.21.2-0.7-0.50.80.20.30.32.2-0.10.5-0.1
Intermittent access terminal intake (last 3 days)0.40.42.1-0.4-0.1-0.3-0.40.7-0.7-0.10.40.01.10.20.00.5-0.3-0.70.30.90.90.91.4-0.70.8-0.4
Intermittent access total infusions0.60.71.7-0.00.2-0.20.31.1-1.1-0.7-0.2-0.71.20.60.30.9-0.9-1.10.80.80.90.91.3-0.71.0-0.9
Intermittent access day 1 locomotion0.90.92.6-0.9-0.6-0.90.11.6-1.6-0.50.1-0.41.30.10.20.4-0.6-1.01.11.31.31.20.9-1.01.0-1.2
Intermittent access day 15 total locomotion0.50.54.3-0.20.10.31.90.1-0.1-0.2-1.7-0.1-0.10.1-0.30.40.00.10.80.30.20.12.10.1-0.10.4
Intermittent access total locomotion0.80.93.1-1.1-0.5-0.81.11.5-1.5-0.3-0.9-0.31.30.1-0.20.3-0.3-1.01.21.21.21.11.8-0.80.8-0.7
Intermittent access standard deviation1.41.55.0-1.1-0.9-0.41.5-0.30.31.4-1.51.41.7-1.1-2.2-0.71.4-1.1-1.4-0.6-0.5-0.51.91.0-0.91.4
Left kidney weight0.41.33.9-0.5-0.1-0.9-0.82.0-2.0-1.20.7-1.00.80.90.60.7-1.1-1.81.90.30.70.7-1.0-0.70.6-1.8
Right kidney weight0.41.24.2-0.30.1-0.70.21.9-1.9-1.4-0.4-1.10.90.90.20.8-1.0-2.01.9-0.4-0.00.0-1.2-0.00.1-1.7
Cocaine induced anxiety0.30.32.4-0.10.2-0.20.2-0.10.1-0.2-0.4-0.10.00.0-0.9-0.20.2-0.70.1-1.6-0.9-0.8-0.21.0-0.90.4
Post-drug Anxiety0.70.82.0-0.00.5-0.5-1.01.2-1.2-1.20.9-1.21.01.00.50.7-1.0-1.11.4-0.00.50.5-0.2-0.50.5-1.2
Baseline Anxiety0.50.51.50.00.1-0.2-0.80.6-0.6-0.50.9-0.50.50.31.00.3-0.70.10.71.21.00.9-0.4-1.10.9-0.9
Tail length0.30.93.0-1.2-1.4-1.21.41.0-1.00.5-1.41.01.4-0.8-1.3-0.90.8-1.7-0.60.30.00.1-0.20.2-0.2-0.2
Length with tail0.72.69.9-2.1-1.8-2.40.63.1-3.1-0.2-0.80.72.6-0.2-0.9-0.2-0.1-3.11.10.60.80.8-0.8-0.50.6-2.0
Length without tail0.71.65.6-1.6-1.1-2.0-0.52.4-2.4-0.40.30.01.80.1-0.30.2-0.4-2.11.60.10.50.5-1.4-0.40.3-1.9
Times rat made contact with spout0.50.63.70.0-0.0-0.41.90.5-0.5-1.0-1.8-0.60.0-0.1-0.40.0-0.2-1.30.4-0.5-0.5-0.4-0.70.5-0.3-0.6
Lifetime Intake0.70.82.5-0.9-0.7-1.1-0.31.4-1.4-0.00.20.01.6-0.1-0.30.1-0.3-1.60.10.91.01.00.5-0.81.0-1.1
Liver weight, left0.40.61.9-1.0-1.0-0.70.0-0.10.11.1-0.21.10.8-0.9-1.4-1.01.20.0-1.1-0.5-0.4-0.4-0.10.6-0.80.9
Liver weight, right1.32.25.40.20.00.61.5-1.81.80.3-1.70.7-1.7-0.3-1.2-0.51.11.2-0.3-2.3-2.3-2.3-0.72.3-2.31.5
Locomotor activity0.81.33.7-1.9-1.9-1.7-0.20.7-0.71.60.11.41.1-1.5-1.3-1.51.2-1.1-1.31.00.90.9-0.3-0.50.3-0.2
Locomotor testing distance1.72.86.8-2.5-2.5-2.3-1.21.0-1.02.61.12.21.9-1.8-1.6-1.81.6-1.1-2.11.61.61.50.3-1.10.9-0.0
Locomotor testing rearing0.71.13.4-1.3-1.5-1.0-1.00.1-0.11.91.01.40.9-1.0-0.6-0.91.0-0.2-1.41.41.21.10.7-0.90.80.2
Locomotion in novel chamber0.91.14.4-0.7-0.5-0.5-2.00.1-0.10.52.10.4-1.4-0.21.2-0.40.11.81.11.61.11.0-0.3-1.30.6-0.1
Locomotion in novel chamber post-restriction0.50.61.9-1.4-1.2-0.90.70.3-0.31.1-0.60.90.6-1.0-1.4-0.91.0-0.6-0.5-0.2-0.0-0.10.50.4-0.50.5
Fecal boli incidents, locomotor time 10.20.20.70.00.10.20.3-0.50.50.2-0.50.20.3-0.1-0.7-0.20.4-0.1-0.4-0.9-0.8-0.70.20.9-0.80.6
Change in fecal boli incidents, locomotor task0.20.20.7-0.3-0.2-0.4-0.30.8-0.8-0.10.4-0.1-0.40.30.40.2-0.3-0.20.70.50.40.4-0.3-0.50.5-0.7
Time >=10cm from walls, locomotor time 11.11.15.90.60.50.4-2.4-0.50.5-0.62.3-0.6-1.9-0.21.4-0.1-0.51.40.70.20.10.1-1.7-0.50.2-0.3
Bouts of movement, locomotor time 10.40.41.21.11.11.00.2-0.60.6-0.9-0.1-1.1-0.90.80.70.5-0.60.30.4-0.4-0.4-0.4-0.30.2-0.10.0
Total resting periods, locomotor time 10.40.51.81.11.11.0-0.3-0.40.4-1.20.3-1.3-0.80.90.70.6-0.80.10.6-0.5-0.4-0.4-0.50.2-0.1-0.2
Rest time, locomotor task time 10.40.51.90.30.10.4-1.4-0.90.90.31.20.1-1.4-0.50.0-0.60.40.6-0.8-0.5-0.4-0.4-1.00.3-0.40.5
Distance moved, locomotor task time 10.60.62.1-0.4-0.1-0.60.81.4-1.4-0.4-0.6-0.40.80.60.40.7-0.7-0.61.10.90.80.80.6-0.80.8-1.0
Vertical activity count, locomotor time 10.40.41.1-0.20.1-0.20.01.1-1.1-0.30.1-0.40.60.70.50.8-0.7-0.21.00.70.80.80.8-0.80.8-0.7
Time >=10cm from walls, locomotor time 20.40.52.7-0.8-0.8-0.8-1.60.2-0.20.41.50.4-0.4-0.8-0.1-0.80.4-0.0-0.00.30.30.3-1.2-0.30.0-0.3
Bouts of movement, locomotor time 20.20.21.0-0.6-0.6-0.6-1.00.0-0.00.50.90.4-0.2-0.4-0.5-0.60.5-0.5-0.6-0.2-0.1-0.1-0.50.1-0.10.1
Total resting periods, locomotor time 20.10.21.1-0.1-0.1-0.1-1.0-0.20.20.20.90.1-0.5-0.1-0.3-0.30.2-0.3-0.3-0.5-0.3-0.3-0.40.3-0.20.1
Rest time, locomotor task time 20.50.61.91.01.10.6-0.40.3-0.3-1.40.3-1.4-0.21.10.81.0-1.2-0.60.8-0.20.00.1-0.1-0.20.5-0.8
Distance moved, locomotor task time 20.10.10.2-0.3-0.3-0.10.10.3-0.30.40.00.4-0.0-0.10.1-0.00.10.40.20.40.30.20.3-0.30.2-0.0
Vertical activity count, locomotor time 20.40.41.4-0.9-1.0-0.6-0.20.1-0.11.20.31.20.0-1.0-0.6-0.80.80.2-1.00.40.30.30.0-0.20.10.3
Light reinforcement 10.91.64.4-1.7-1.8-1.40.4-0.20.22.0-0.41.70.3-1.8-2.1-1.71.8-0.6-2.0-0.5-0.4-0.4-0.50.8-0.80.8
Light reinforcement 21.01.33.9-1.5-1.7-1.2-0.2-0.10.12.00.11.70.7-1.4-1.9-1.51.7-0.3-1.8-0.5-0.4-0.4-0.50.7-0.80.9
Bone: marrow area2.75.913.7-2.8-2.1-2.8-3.13.2-3.21.63.21.02.4-0.5-0.1-0.4-0.2-1.90.13.13.73.61.6-3.13.0-2.0
Bone: maximum diameter1.62.97.9-2.8-2.3-2.6-1.91.8-1.82.31.72.01.8-1.8-1.8-1.61.3-1.3-1.40.81.51.40.1-0.80.6-0.3
Bone: maximum force0.81.45.0-2.2-1.8-1.50.00.8-0.81.9-0.21.31.3-1.0-2.1-1.01.5-0.9-0.5-0.8-0.3-0.30.60.8-0.90.6
Bone: maximum moment0.91.65.6-2.4-1.9-1.6-0.20.7-0.72.1-0.11.71.2-1.2-2.2-1.21.7-0.6-0.6-0.8-0.4-0.40.40.9-1.10.7
Mean time between licks in bursts1.92.77.11.31.90.90.51.6-1.6-2.5-0.4-2.41.52.41.52.5-2.4-1.62.70.20.60.61.2-0.71.1-1.7
Mean num. licks in bursts0.81.02.9-0.5-0.50.20.6-0.80.81.1-0.71.1-0.2-0.6-1.5-0.81.40.7-1.0-1.2-1.1-1.11.31.3-1.21.7
Cd content in liver1.41.65.62.42.02.1-0.2-1.31.3-1.40.4-1.4-1.01.42.01.2-1.21.90.30.2-0.2-0.20.0-0.30.40.2
Co content in liver1.71.96.70.60.2-0.1-1.80.2-0.2-1.32.0-0.8-0.00.22.40.2-1.20.70.82.61.81.7-1.5-2.31.9-1.5
Cu content in liver1.11.35.3-0.9-1.3-1.6-1.50.6-0.60.31.50.8-0.5-1.30.2-1.10.2-0.9-1.01.41.21.3-2.3-1.31.0-1.2
Fe content in liver1.72.17.52.21.52.01.0-1.71.7-0.9-1.0-0.2-2.70.50.60.5-0.11.8-0.5-1.8-1.9-1.9-0.71.5-1.21.2
K content in liver2.42.410.0-1.4-1.8-1.6-1.5-1.11.11.61.41.8-1.4-2.6-0.8-2.61.70.4-2.20.60.10.2-3.2-0.2-0.40.3
Mg content in liver3.53.612.2-0.1-1.0-0.2-0.8-3.03.01.40.71.9-2.9-2.8-0.5-2.72.01.9-3.00.0-0.8-0.7-3.50.5-1.21.5
Mn content in liver4.85.412.1-1.6-2.1-1.41.3-2.02.02.4-1.62.9-1.2-3.4-3.0-3.53.10.4-3.3-1.6-1.9-1.9-2.82.1-2.62.1
Na content in liver0.70.73.5-0.6-1.1-0.6-0.9-0.60.61.31.00.7-0.9-1.0-0.2-1.10.90.3-1.91.00.70.7-0.4-0.70.60.3
Rb content in liver1.72.27.10.4-0.10.6-2.0-2.52.51.22.01.1-2.1-1.40.5-1.41.12.7-1.60.2-0.4-0.5-2.10.1-0.71.4
Se content in liver0.80.93.31.81.51.10.7-0.50.5-1.5-0.6-1.5-1.40.71.30.8-1.3-0.30.0-0.0-0.10.0-1.1-0.30.5-0.8
Sr content in liver0.90.82.40.50.70.0-1.10.6-0.6-1.41.2-1.1-0.40.91.30.6-1.20.21.50.50.60.6-0.6-0.80.7-1.0
Zn content in liver0.30.32.6-0.2-0.4-0.4-0.9-0.50.50.30.90.2-0.2-0.90.2-0.80.40.1-0.60.50.20.2-1.6-0.3-0.0-0.0
Bone: minimum diameter3.36.315.9-4.0-3.1-3.8-2.63.4-3.42.22.41.93.3-1.6-1.5-1.40.7-2.6-0.22.33.02.90.6-2.21.8-1.7
Time in familiar zone, hab. session 11.01.04.01.31.41.42.0-0.40.4-0.9-1.8-0.90.11.30.51.3-0.90.00.6-0.1-0.2-0.21.60.20.10.0
Time in novel zone, hab. session 10.70.74.4-0.7-0.8-1.0-2.10.4-0.40.11.90.4-0.4-0.80.2-0.80.30.20.00.30.30.3-1.5-0.40.2-0.4
Total zone transitions, hab. session 11.01.33.71.51.81.51.1-0.30.3-1.7-1.0-1.7-0.11.91.31.6-1.40.71.8-0.2-0.1-0.11.1-0.00.2-0.3
Total locomotion distance, hab. session 10.10.10.5-0.7-0.4-0.3-0.10.2-0.20.5-0.00.60.5-0.0-0.4-0.10.30.30.4-0.10.0-0.00.70.1-0.20.2
Locomotion velocity, hab. session 10.10.20.8-0.8-0.4-0.4-0.10.3-0.30.6-0.00.60.90.0-0.5-0.10.30.10.4-0.00.20.10.80.0-0.10.1
Time in familiar zone, hab. session 21.21.26.01.11.11.02.40.3-0.3-1.2-2.2-1.30.91.30.51.5-1.0-0.91.3-0.2-0.4-0.41.10.4-0.0-0.4
Time in novel zone, hab. session 21.41.47.2-1.1-1.1-1.0-2.7-0.50.51.22.41.4-1.1-1.5-0.5-1.61.21.4-1.0-0.20.0-0.0-1.50.0-0.40.7
Total zone transitions, hab. session 21.01.33.31.81.71.60.7-0.90.9-1.7-0.5-1.5-0.91.41.81.3-1.31.31.40.3-0.1-0.10.1-0.30.3-0.3
Total locomotion distance, hab. session 20.50.61.61.21.21.30.6-0.70.7-1.1-0.5-0.7-0.71.01.10.9-0.81.00.9-0.0-0.2-0.20.3-0.00.0-0.0
Locomotion velocity, hab. session 20.50.71.91.31.31.40.8-0.70.7-1.1-0.7-0.8-0.71.11.01.0-0.81.00.9-0.2-0.3-0.30.50.1-0.00.1
Novel to familiar place preference ratio0.30.31.1-1.1-0.8-0.8-0.70.5-0.50.90.60.70.8-0.6-0.9-0.40.6-0.5-0.4-0.10.20.10.40.1-0.10.1
Novelty place preference0.30.31.1-1.0-0.9-0.8-0.80.3-0.30.90.70.70.7-0.7-0.9-0.50.7-0.3-0.4-0.20.00.00.10.2-0.20.2
Time in novel zone, NPP test0.30.30.9-1.0-0.8-0.8-0.70.2-0.20.90.60.80.5-0.7-0.9-0.60.7-0.2-0.4-0.4-0.2-0.2-0.20.3-0.40.3
Total zone transitions, NPP test1.01.44.31.51.61.91.0-1.81.8-0.7-1.0-1.1-1.00.90.70.7-0.32.10.5-0.8-0.8-0.91.00.7-0.71.2
Total locomotion distance, NPP test0.20.31.20.10.20.40.3-0.90.90.2-0.40.1-0.4-0.1-0.3-0.20.41.10.0-0.7-0.6-0.60.30.6-0.70.8
Locomotion velocity, NPP test0.10.20.80.30.50.60.2-0.70.7-0.0-0.3-0.2-0.10.2-0.00.20.00.90.2-0.3-0.2-0.20.90.2-0.30.6
Intraocular pressure0.60.81.80.30.4-0.1-0.11.3-1.3-1.00.3-0.80.60.81.00.7-1.1-1.10.61.21.11.20.2-1.21.3-1.3
Delta distance traveled before/after self-admin0.50.52.20.60.70.81.5-0.80.8-0.1-1.4-0.1-0.60.2-0.30.10.10.20.0-1.0-0.8-0.80.50.9-0.80.8
Delta ambulatory time before/after self-admin0.80.85.40.30.60.62.3-0.30.3-0.1-2.2-0.10.20.4-0.80.30.1-0.50.2-1.2-0.9-0.91.11.1-0.90.7
Parametrial fat weight0.81.55.6-1.3-1.1-0.71.40.1-0.11.2-1.60.71.6-0.6-2.4-0.81.5-0.9-0.7-1.3-1.0-1.01.11.5-1.41.3
Pavlov. Cond. lever latency1.21.65.82.42.11.90.3-1.31.3-1.9-0.3-1.5-1.71.31.41.3-1.31.20.2-0.8-0.6-0.60.20.30.10.1
Pavlov. Cond. magazine entry latency2.43.08.5-2.9-2.9-2.00.5-0.10.12.9-0.62.61.2-2.3-2.6-2.42.7-0.8-1.5-0.0-0.4-0.4-0.40.8-1.31.1
Pavlov. Cond. change in total contacts1.41.54.2-1.9-2.0-1.7-0.50.6-0.61.30.51.60.9-1.6-1.1-1.71.2-1.3-1.21.41.01.0-0.9-0.80.4-0.3
Pavlov. Cond. index score1.62.06.5-2.6-2.5-1.90.00.7-0.72.4-0.12.01.6-1.6-1.9-1.71.8-1.3-1.00.60.40.4-0.00.0-0.40.3
Pavlov. Cond. latency score1.41.76.0-2.4-2.3-1.90.10.9-0.92.0-0.11.81.6-1.5-1.7-1.61.6-1.4-0.70.70.40.4-0.3-0.1-0.40.1
Pavlov. Cond. lever contacts1.21.43.8-2.0-1.7-1.8-0.21.6-1.61.10.20.91.8-0.7-0.8-0.80.6-1.70.01.21.11.1-0.2-0.80.5-0.8
Pavlov. Cond. magazine entry number2.73.49.62.62.91.8-0.50.5-0.5-3.10.5-2.7-0.72.62.72.7-2.90.52.20.10.50.50.6-0.91.3-1.5
Pavlov. Cond. intertrial magazine entries0.70.82.10.50.50.10.31.2-1.2-0.6-0.2-0.40.60.80.61.0-1.2-1.40.10.91.21.21.0-1.11.4-1.1
Pavlov. Cond. lever-magazine prob. diff.1.72.06.9-2.6-2.5-2.0-0.40.7-0.72.30.42.01.6-1.7-1.8-1.81.8-1.3-1.00.80.60.6-0.2-0.2-0.20.3
Pavlov. Cond. response bias2.53.19.3-3.0-3.0-2.2-0.10.2-0.23.00.02.61.1-2.3-2.5-2.52.6-0.8-1.70.3-0.0-0.1-0.50.5-1.01.0
Pavlov. Cond. lever latency0.40.62.00.81.00.71.40.3-0.3-1.1-1.3-1.3-0.01.00.41.0-0.8-0.60.9-0.4-0.3-0.20.70.20.0-0.3
Pavlov. Cond. magazine entry latency0.30.41.01.00.90.9-0.4-0.70.7-0.60.4-0.6-0.70.51.00.7-0.61.00.40.1-0.1-0.1-0.1-0.10.1-0.0
Pavlov. Cond. change in total contacts0.91.34.1-0.8-1.2-1.2-1.60.1-0.10.71.71.10.1-1.00.7-1.00.30.4-0.82.01.41.4-1.5-1.61.2-0.8
Pavlov. Cond. index score0.40.52.8-0.4-0.5-0.6-1.7-0.10.10.31.60.7-0.1-0.60.5-0.50.10.7-0.20.90.80.7-1.0-0.90.6-0.4
Pavlov. Cond. latency score0.40.52.7-0.5-0.6-0.7-1.60.1-0.10.41.60.60.1-0.50.4-0.40.10.5-0.30.90.80.8-0.8-0.80.6-0.5
Pavlov. Cond. lever contacts0.40.61.7-0.9-1.1-0.8-1.0-0.40.41.00.81.3-0.1-1.1-0.5-1.10.90.4-0.80.1-0.1-0.1-1.20.1-0.40.2
Pavlov. Cond. magazine entry number0.30.42.2-0.8-0.6-0.80.71.0-1.00.2-0.70.21.0-0.2-0.8-0.30.2-1.5-0.20.30.40.40.5-0.20.3-0.3
Pavlov. Cond. intertrial magazine entries1.92.57.1-2.5-2.1-2.50.32.0-2.01.1-0.21.02.7-1.2-1.6-1.20.8-2.3-0.81.61.81.70.6-1.21.0-0.7
Pavlov. Cond. lever-magazine prob. diff.0.40.52.4-0.2-0.4-0.5-1.6-0.10.10.21.50.5-0.2-0.40.6-0.3-0.00.8-0.10.90.70.7-0.9-0.80.6-0.4
Pavlov. Cond. response bias0.30.41.0-0.4-0.6-0.3-0.7-0.80.80.80.61.0-0.6-0.9-0.3-0.80.80.9-0.6-0.1-0.3-0.3-1.00.3-0.50.5
Time in closed arm before self-admin2.42.86.01.00.51.12.0-2.52.50.6-2.10.6-1.2-0.9-1.0-0.81.21.3-1.4-2.2-2.4-2.4-1.02.3-2.21.9
Time in closed arm after self-admin6.36.422.52.22.12.94.7-2.72.7-0.7-4.7-0.9-1.20.8-1.10.90.40.8-0.3-3.6-3.5-3.41.33.5-2.92.4
Time in open arm before self-admin2.83.09.80.81.50.6-2.01.8-1.8-2.02.1-2.1-0.12.22.22.2-2.3-0.33.10.81.31.20.9-1.51.6-1.9
Time in open arm after self-admin4.95.411.3-0.8-0.4-1.6-2.73.2-3.2-1.12.8-1.02.11.01.91.0-2.0-1.51.73.23.43.30.2-3.43.3-3.1
Bone: periosteal estimation2.34.713.5-3.7-3.0-3.3-2.82.5-2.52.62.62.32.2-1.9-1.8-1.71.3-1.7-0.91.52.22.10.4-1.51.2-0.9
Bone: periosteal perimeter2.64.39.1-2.9-2.4-3.0-2.93.0-3.01.62.71.32.5-1.2-0.8-1.00.3-2.2-0.01.82.42.30.1-1.91.7-1.7
Bone: post-yield work2.63.510.4-1.0-0.2-1.2-1.33.2-3.2-0.71.4-1.22.61.40.71.4-1.6-2.12.21.72.22.21.6-1.92.1-2.3
Progressive ratio test 1 active lever presses1.01.12.9-1.1-1.1-1.3-1.21.1-1.10.41.30.41.5-0.70.2-0.4-0.0-0.7-0.01.71.51.5-0.2-1.41.2-1.0
Progressive ratio test 1 breakpoint1.61.64.2-1.2-1.2-1.5-1.81.3-1.30.31.80.41.7-0.70.3-0.4-0.1-0.9-0.02.11.81.8-0.2-1.71.5-1.2
Progressive ratio test 1 inactive lever presses2.12.35.9-2.4-2.4-2.3-0.21.1-1.11.80.11.82.4-2.1-2.0-1.81.5-1.9-1.80.80.80.8-0.5-0.30.2-0.3
Progressive ratio test 2 active lever presses0.40.41.5-0.8-0.6-0.70.10.7-0.70.20.10.20.9-0.5-0.1-0.20.1-0.50.11.21.11.10.7-0.90.7-0.4
Progressive ratio test 2 breakpoint0.40.41.6-0.8-0.6-0.60.30.7-0.70.2-0.10.21.3-0.5-0.2-0.20.1-0.70.11.11.01.01.0-0.80.7-0.3
Progressive ratio test 2 inactive lever presses1.41.65.9-1.8-1.6-2.01.01.5-1.50.6-0.90.62.1-1.0-1.3-0.80.5-2.4-0.71.11.11.1-0.0-0.60.6-0.9
Incentive Sensitization - Responses0.40.41.0-1.0-0.9-0.6-0.60.1-0.11.00.71.00.1-0.8-0.3-0.70.70.1-0.40.90.80.70.5-0.60.30.2
Incentive Sensitization - Breakpoint0.40.41.1-0.9-0.9-0.4-0.4-0.10.11.00.51.0-0.2-0.9-0.4-0.70.70.3-0.50.80.70.60.5-0.50.20.4
Sum of active levers in priming session hrs 5-61.21.24.10.90.40.7-1.9-0.80.80.02.00.1-1.50.11.70.1-0.51.8-0.51.61.01.0-0.2-1.31.2-0.1
Progressive ratio0.20.31.20.10.10.50.0-0.90.90.50.00.4-0.1-0.3-0.4-0.10.60.8-0.7-0.2-0.2-0.21.10.3-0.41.1
Food seeking constrained by brief footshock0.20.31.4-0.2-0.0-0.21.20.2-0.2-0.2-1.0-0.00.40.20.10.2-0.2-0.1-0.01.00.90.90.7-0.70.6-0.3
Seeking ratio, punishment vs. effort0.50.62.0-0.2-0.2-0.70.41.2-1.2-0.7-0.2-0.50.60.50.50.3-0.8-1.00.60.90.91.0-0.7-1.01.0-1.4
Retroperitoneal fat weight0.41.46.6-1.2-1.0-1.12.51.1-1.10.2-2.60.40.7-0.4-1.5-0.50.8-1.60.6-0.9-0.9-0.9-0.41.1-1.2-0.0
Reaction time number correct0.20.30.90.10.2-0.4-0.81.0-1.0-0.60.7-0.30.70.20.30.1-0.6-0.70.4-0.10.20.3-0.3-0.30.5-0.7
Reaction time mean minus median0.30.41.0-0.6-0.8-0.90.00.3-0.3-0.0-0.00.50.1-0.5-0.3-0.90.3-0.8-0.90.70.60.7-1.0-0.50.5-0.5
Reaction time mean minus median AUC0.60.73.4-0.5-0.9-0.7-0.3-0.80.80.60.21.1-0.7-1.3-0.8-1.61.10.1-1.9-0.0-0.2-0.1-1.40.2-0.30.5
Reaction time num false alarms0.81.15.0-0.9-0.7-1.20.12.0-2.0-0.4-0.0-0.71.50.1-0.50.1-0.4-2.20.10.71.01.00.7-0.81.0-1.2
Reaction time num false alarms AUC0.81.05.1-1.2-0.9-1.30.41.9-1.9-0.1-0.3-0.31.5-0.3-0.9-0.2-0.0-2.3-0.10.70.90.90.7-0.60.8-0.9
Reaction time trials correct on left0.20.30.90.10.2-0.4-0.81.0-1.0-0.60.7-0.30.70.20.30.1-0.6-0.70.4-0.10.20.3-0.3-0.30.5-0.7
Reaction time trials on left0.20.30.9-0.00.0-0.5-0.90.9-0.9-0.50.8-0.20.70.10.2-0.0-0.5-0.60.3-0.00.30.3-0.4-0.30.4-0.7
Reaction time mean0.81.24.7-0.9-1.4-1.1-0.6-1.11.11.00.61.2-1.1-1.4-0.6-1.71.20.2-2.00.60.30.3-2.2-0.3-0.10.2
Reaction time mean AUC0.81.14.4-0.6-1.2-0.9-0.9-1.21.20.90.91.1-1.2-1.3-0.4-1.61.10.5-2.00.60.30.3-2.1-0.30.00.2
Median of all reaction times1.01.45.5-1.0-1.5-1.2-1.1-1.11.11.21.01.2-1.3-1.6-0.5-1.81.30.4-1.90.70.30.3-2.3-0.4-0.10.2
Reaction time omissions2.83.810.5-2.6-3.0-2.4-1.2-0.50.52.61.02.9-0.3-3.1-2.2-3.22.90.3-2.60.30.0-0.0-2.00.3-0.91.1
Reaction time false alarm rate0.40.62.8-0.9-0.8-0.80.61.2-1.20.1-0.5-0.21.1-0.2-0.8-0.10.1-1.7-0.30.70.80.81.0-0.50.6-0.4
Reaction time premature initiation rate0.60.72.7-1.2-1.0-0.71.21.0-1.00.9-1.10.61.6-0.2-1.4-0.30.7-1.2-0.3-0.3-0.1-0.10.80.4-0.40.2
Reaction time premature initiations0.60.83.9-1.1-1.0-0.81.01.4-1.40.6-1.00.52.0-0.2-1.3-0.30.5-1.6-0.3-0.3-0.0-0.00.70.3-0.1-0.1
Std. dev. reaction times0.71.03.9-0.7-1.2-0.80.1-1.21.20.8-0.11.2-1.0-1.5-0.8-1.81.30.3-2.00.3-0.0-0.0-1.70.1-0.40.5
Reaction time trials completed0.20.30.9-0.00.0-0.5-0.90.9-0.9-0.50.8-0.20.70.10.2-0.0-0.5-0.60.3-0.00.30.3-0.4-0.30.4-0.7
Reaction time trials AUC0.20.20.70.00.1-0.4-0.80.8-0.8-0.60.7-0.20.60.10.2-0.0-0.5-0.60.3-0.00.20.3-0.4-0.30.4-0.7
Run reversals in cocaine runway, females0.80.82.50.71.20.8-0.40.6-0.6-1.40.5-1.3-0.01.41.01.3-1.3-0.41.6-0.00.50.50.9-0.60.7-0.6
Run reversals in cocaine runway, males0.40.41.5-1.2-1.0-1.00.10.4-0.40.8-0.20.90.4-0.5-1.0-0.60.8-0.60.0-0.2-0.1-0.1-0.30.3-0.50.1
Latency to leave start box in cocaine runway0.91.03.31.11.41.3-0.20.2-0.2-1.20.1-1.20.51.60.91.7-1.10.11.8-0.5-0.4-0.41.50.3-0.0-0.1
Latency to leave start box in cocaine runway, F2.52.87.91.72.21.7-1.11.0-1.0-2.21.0-2.20.92.71.82.8-2.3-0.22.8-0.10.20.22.4-0.40.9-0.9
Latency to leave start box in cocaine runway, M1.51.42.6-0.4-0.8-0.01.0-1.61.61.1-1.11.1-1.0-1.3-1.0-1.41.61.0-1.1-0.8-1.3-1.3-1.21.3-1.61.4
Std. dev. time between licks in bursts0.70.81.70.70.90.7-0.80.7-0.7-0.80.8-0.90.71.21.11.2-1.3-0.51.10.60.70.70.9-0.81.0-0.9
Total sessions with >9 infusions0.50.62.3-0.4-0.4-0.7-0.11.1-1.1-0.20.2-0.21.50.20.20.4-0.5-1.00.21.00.91.00.3-0.91.1-1.1
Short access day 1 total inactive lever presses0.50.61.8-1.1-1.0-1.3-1.30.8-0.80.61.20.6-0.0-0.50.0-0.60.2-0.10.10.80.70.7-1.1-0.70.5-0.8
Short access day 10 total inactive lever presses2.02.29.2-2.2-1.8-2.41.42.3-2.30.8-1.50.92.0-0.6-2.0-0.80.6-3.0-0.70.30.70.70.0-0.10.3-1.1
Short access day 1 total infusions1.21.33.8-1.4-1.7-1.9-0.41.2-1.21.00.31.01.6-1.0-0.8-0.90.5-1.6-1.21.00.80.9-1.2-0.70.8-1.1
Short access day 10 total infusions1.21.33.2-1.6-1.5-1.8-0.91.6-1.60.50.90.51.8-0.8-0.5-0.50.2-1.6-0.21.31.31.30.0-1.11.0-1.1
Short access total infusions1.71.95.1-1.8-1.8-2.3-1.01.7-1.70.80.90.82.2-1.0-0.9-0.90.3-2.2-0.91.31.31.3-0.7-1.01.1-1.4
Short access day 1 locomotion0.91.03.2-1.8-1.8-1.7-0.51.0-1.01.20.41.30.8-1.2-0.9-1.00.8-0.7-0.60.80.70.7-0.2-0.40.4-0.5
Short access day 10 total locomotion2.83.16.8-2.5-2.0-2.41.82.6-2.60.5-1.50.52.5-0.9-1.0-0.60.3-2.40.42.32.12.01.4-1.51.3-1.4
Short access total locomotion3.03.17.6-2.0-1.7-2.3-0.32.8-2.80.10.40.12.5-0.5-0.1-0.2-0.4-2.30.72.62.42.40.5-2.02.0-2.1
One hour access (0.3 mA shock)0.40.43.30.40.70.7-0.60.1-0.1-0.60.6-0.50.50.70.41.0-0.60.11.00.20.40.31.8-0.30.40.0
Compulsive drug intake0.90.92.71.11.11.3-0.4-1.31.3-0.30.1-0.3-1.00.50.20.5-0.01.40.4-1.7-1.3-1.30.21.2-1.11.0
One hour access (shock baseline)1.01.12.0-0.20.2-0.30.31.4-1.4-1.1-0.1-1.00.90.90.60.9-1.1-1.21.21.41.41.41.3-1.21.3-1.2
Social response proportion2.42.68.4-0.30.1-1.20.02.5-2.5-2.1-0.1-1.51.21.01.20.8-1.8-2.42.21.21.31.4-1.5-1.51.5-2.9
Social responses0.30.31.6-0.7-0.6-0.81.10.7-0.7-0.2-1.10.10.5-0.3-0.5-0.20.1-1.30.40.10.10.1-0.50.0-0.1-0.6
Social time2.63.49.6-1.4-1.1-2.4-1.32.6-2.6-0.71.3-0.31.9-0.10.7-0.1-1.2-2.81.02.02.22.2-2.3-2.22.0-3.1
Soleus weight0.31.02.30.00.4-0.4-0.41.5-1.5-1.30.4-0.90.50.81.00.7-1.3-0.81.40.91.21.2-0.1-1.21.2-1.5
Bone: stiffness0.30.43.3-0.10.10.51.2-0.10.10.6-1.1-0.30.40.5-0.70.40.30.2-0.0-0.6-0.4-0.41.80.6-0.50.8
Tibialis anterior weight0.62.04.20.60.90.0-0.01.7-1.7-1.80.2-1.51.11.31.71.5-2.0-1.11.81.61.61.60.5-1.71.8-2.1
Time to tail flick, vehicle, before self-admin1.31.46.31.21.31.5-2.5-1.41.4-0.52.3-0.5-1.50.51.20.5-0.31.90.7-0.6-0.4-0.50.30.1-0.30.9
Time to tail flick, vehicle, after self-admin0.30.40.9-0.8-1.0-0.80.80.0-0.00.8-0.80.70.8-0.7-0.8-0.70.8-0.4-0.90.20.00.00.10.1-0.10.2
Time to tail flick, test, before self-admin1.51.54.91.81.81.30.3-0.30.3-1.9-0.1-1.7-1.11.32.21.1-1.71.01.50.80.50.5-0.6-0.90.8-0.8
Time to tail flick, test, after self-admin0.30.31.7-0.2-0.2-0.5-1.30.3-0.3-0.01.3-0.00.1-0.30.4-0.3-0.20.0-0.10.80.70.7-0.5-0.80.7-0.4
Delta time to tail flick, vehicle, before/after SA1.91.84.5-1.9-2.1-2.01.60.9-0.91.5-1.61.41.8-1.5-1.8-1.51.3-1.5-1.60.80.60.6-0.2-0.20.1-0.2
Delta time to tail flick, test, before/after SA1.51.43.8-1.7-1.9-1.8-1.90.7-0.71.51.81.40.6-1.5-1.0-1.31.1-0.6-1.30.70.60.6-0.6-0.50.3-0.1
Tibia length1.02.912.50.50.81.03.40.1-0.1-0.9-3.5-0.50.61.0-1.21.2-0.0-0.71.5-2.8-2.5-2.51.02.6-2.20.7
Ambulatory time before self-admin0.60.72.2-0.5-0.6-0.5-1.40.8-0.80.21.50.1-0.00.10.6-0.1-0.30.3-0.11.31.21.2-0.1-1.21.2-0.8
Ambulatory time after self-admin0.10.10.3-0.4-0.1-0.1-0.10.6-0.60.20.10.1-0.10.30.10.2-0.1-0.10.40.20.50.40.4-0.30.3-0.3
Bone: tissue strength1.61.57.40.70.91.12.7-0.40.4-0.0-2.6-0.60.30.8-0.80.70.1-0.10.2-1.8-1.6-1.61.21.7-1.41.1
Total heroin consumption1.11.36.1-1.0-1.2-1.0-2.50.1-0.11.32.41.2-1.0-1.10.3-1.10.70.8-0.81.31.01.0-1.1-1.10.7-0.2
Bone: trabecular number2.43.810.7-3.3-3.2-2.8-0.60.4-0.42.80.32.71.4-2.8-2.9-2.82.7-1.0-1.6-0.5-0.4-0.5-1.50.9-1.40.8
Bone: trabecular spacing1.52.04.92.02.11.91.5-0.20.2-1.9-1.2-2.2-0.22.21.62.1-1.80.11.20.40.30.41.7-0.50.9-0.5
Bone: trabecular thickness1.11.34.1-2.0-1.8-2.0-1.31.7-1.71.21.11.21.2-1.0-1.2-1.00.8-1.3-0.10.10.40.4-0.6-0.10.0-0.5
Bone: trabecular tissue density0.91.22.60.40.30.91.4-1.41.40.5-1.4-0.1-0.8-0.1-0.9-0.20.80.8-0.6-1.6-1.6-1.60.31.6-1.61.5
Water consumed over 24 hours0.50.62.50.30.3-0.11.6-0.10.1-0.9-1.6-0.5-0.9-0.3-0.5-0.1-0.0-0.30.2-1.1-1.0-1.0-1.01.0-0.9-0.0
Number of responses in last shaping day2.12.27.5-1.5-1.0-1.9-0.52.7-2.7-0.20.5-0.32.40.5-0.40.5-0.7-2.60.81.01.51.50.7-1.21.4-1.9