Hub : Genes

Fmnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr10_88627953_88630432 0.04 0.02 1.6e-03 0.03 0.02 0.01 0.01 1.0e-03 9.1e-03 3.9e-02 1.5e-02
2 NAcc gene expression Fmnl1 0.02 0.01 1.0e-03 0.01 0.02 0.01 0.01 2.9e-02 5.4e-04 2.6e-02 1.4e-02
3 Liver alternative polyA NM_001105846.1 0.07 0.05 4.0e-03 0.03 0.02 0.01 0.02 6.2e-04 4.8e-03 7.9e-03 5.9e-03
4 Brain alternative polyA NM_001105846.1 0.23 0.08 0.0e+00 0.19 0.2 0.2 0.2 3.3e-17 1.0e-18 3.5e-18 8.8e-19
5 Brain alternative polyA XM_006247499.5 0.22 0.08 0.0e+00 0.18 0.19 0.18 0.2 3.8e-16 8.6e-18 2.0e-16 6.6e-18
6 pVTA alternative polyA NM_001105846.1 0.04 0.03 2.1e-03 0.02 0.03 0.04 0.04 8.7e-03 1.2e-03 5.9e-04 7.4e-04
7 Liver gene expression Fmnl1 0.02 0.02 3.9e-03 0.02 0.01 0.01 0.01 1.3e-03 2.9e-02 6.1e-02 4.3e-02
8 PL gene expression Fmnl1 0.06 0.03 3.6e-06 0.06 0.05 0.04 0.05 3.4e-07 4.7e-06 7.2e-05 3.2e-06
9 Adipose gene expression Fmnl1 0.25 0.09 0.0e+00 0.2 0.17 0.18 0.19 1.2e-21 7.2e-19 6.0e-20 2.5e-20
10 Adipose mRNA stability Fmnl1 0.09 0.04 3.6e-10 0.06 0.07 0.06 0.07 1.1e-07 2.1e-08 2.0e-07 3.6e-08
11 Brain mRNA stability Fmnl1 0.14 0.08 7.2e-05 0.01 0.04 0.04 0.03 2.0e-02 4.8e-05 1.4e-04 1.1e-03
12 Adipose isoform ratio NM_001105846.1 0.09 0.06 1.0e-03 0.01 0.03 0.02 0.01 3.2e-02 3.5e-04 1.6e-03 6.8e-03
13 Brain gene expression Fmnl1 0.09 0.04 1.1e-05 0.03 0.06 0.05 0.04 1.0e-03 5.2e-06 4.1e-05 6.5e-05
14 Adipose alternative polyA XM_006247499.5 0.15 0.06 1.9e-09 0.03 0.07 0.08 0.07 1.1e-04 1.2e-08 4.7e-09 1.4e-08
15 Adipose alternative polyA NM_001105846.1 0.15 0.06 2.8e-09 0.03 0.07 0.08 0.07 1.4e-04 1.7e-08 7.1e-09 1.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.83.35.41.8-1.9-2.1-2.12.01.2-2.02.0-1.92.1-0.81.7-2.31.2-1.2
Area under the delay curve0.10.10.90.00.10.90.0-0.10.10.1-0.00.4-0.40.2-0.60.4-0.40.4
BMI with tail1.24.19.2-0.52.80.52.0-2.1-2.92.4-2.22.8-2.33.0-1.51.0-0.00.0
BMI without tail0.31.67.61.31.3-0.30.7-0.8-1.51.1-1.11.7-1.22.7-1.3-0.1-0.50.5
Body weight0.94.222.82.01.5-2.31.2-1.3-2.81.5-1.72.2-1.84.8-2.00.4-0.30.3
Weight adjusted by age0.30.82.90.5-0.30.60.2-0.20.00.1-0.20.2-0.70.9-1.71.3-1.51.6
Bone surface2.54.912.83.6-2.8-1.2-2.82.81.8-2.72.7-2.52.3-0.10.3-2.5-0.00.1
Bone volume2.04.07.82.8-2.3-1.3-2.62.61.7-2.42.4-2.12.3-0.30.8-2.50.6-0.6
Breakpoint value in progressive ratio session0.61.23.11.1-1.21.8-0.90.91.3-0.90.8-0.70.4-0.9-0.4-0.2-1.61.6
Number of licking bursts0.61.93.4-0.51.1-0.21.8-1.8-1.81.3-1.81.2-1.71.3-0.91.4-1.11.1
Context. condit. distance diff. score1.82.24.1-1.71.8-0.41.7-1.8-1.52.0-1.71.9-1.61.4-0.71.70.0-0.0
Locomotion velocity, session 10.30.40.80.2-0.5-0.5-0.80.80.7-0.50.6-0.60.9-0.20.4-0.70.6-0.7
Locomotion distance, session 10.20.20.6-0.0-0.1-0.0-0.60.50.5-0.00.6-0.10.7-0.20.4-0.70.7-0.8
Locomotion velocity, session 20.91.02.0-0.0-1.0-0.9-1.21.21.2-1.11.3-1.11.4-1.10.8-0.60.8-0.8
Locomotion distance, session 20.30.51.20.2-0.6-0.2-0.80.80.9-0.60.8-0.71.1-0.70.4-0.80.4-0.4
Locomotion velocity, session 30.40.41.9-0.10.1-1.2-0.20.2-0.40.00.30.00.20.40.7-0.41.4-1.4
Locomotion distance, session 30.30.30.9-0.30.4-0.40.6-0.6-0.80.9-0.60.7-0.70.8-0.40.70.1-0.1
Stereotopy head waving bouts, day 30.91.04.1-0.50.20.2-0.70.70.3-0.51.0-0.20.7-1.11.5-0.92.0-2.0
Stereotopy head waving duration, day 30.30.30.9-0.70.40.8-0.30.30.4-0.40.60.10.2-0.90.8-0.20.9-0.9
Locomotion velocity, session 70.80.82.3-1.21.0-1.10.7-0.8-0.90.3-0.70.7-0.30.11.10.21.5-1.5
Locomotion distance, session 70.20.30.8-0.90.5-0.80.6-0.6-0.40.3-0.40.6-0.40.4-0.10.80.1-0.0
Stereotopy head waving bouts, day 70.60.71.90.3-0.8-0.6-0.40.50.1-1.20.7-1.30.7-1.41.3-0.60.7-0.7
Stereotopy head waving duration, day 70.50.73.3-0.3-0.4-0.1-0.00.20.1-1.00.4-1.10.6-1.81.5-0.30.8-0.8
Locomotion velocity, session 80.50.61.8-0.41.3-0.40.4-0.5-0.91.1-0.51.1-0.31.00.1-0.40.9-1.0
Locomotion distance, session 80.20.31.5-1.20.7-0.10.5-0.5-0.10.9-0.50.7-0.20.1-0.10.60.3-0.3
Degree of sensitization distance0.10.20.60.00.3-0.50.1-0.10.10.0-0.10.4-0.20.8-0.60.4-0.50.5
Degree of sensitization stereotypy0.30.31.00.0-0.5-1.00.1-0.0-0.3-1.00.1-1.00.3-0.90.90.10.2-0.2
Conditioned locomotion0.10.10.6-0.20.0-0.80.0-0.00.00.10.10.1-0.00.10.5-0.00.7-0.7
Cocaine response after cond. corrected0.40.65.50.10.1-2.30.1-0.1-1.00.1-0.1-0.00.01.00.40.01.0-0.9
Cocaine response after cond. not corrected0.91.311.70.5-0.7-3.4-0.50.5-0.5-0.60.5-0.90.80.60.9-0.51.2-1.1
Cocaine response before conditioning0.81.01.80.6-1.2-0.9-1.21.20.9-1.31.1-1.31.3-1.10.8-1.0-0.00.1
Saline control response0.20.30.90.7-0.30.6-0.40.30.6-0.30.30.00.1-0.1-0.2-0.6-0.90.9
Bone: connectivity density2.43.96.62.4-2.6-1.7-2.42.41.9-2.42.3-2.42.3-0.90.9-2.10.2-0.2
Bone: cortical apparent density1.42.110.4-2.30.30.8-0.00.10.7-0.40.6-0.60.9-3.22.5-0.41.9-1.9
Bone: cortical area1.72.85.42.2-1.6-0.4-2.02.01.1-2.22.0-1.81.9-0.51.0-2.31.1-1.0
Bone: cortical porosity4.65.017.74.2-2.9-1.4-2.82.81.9-2.22.4-2.01.91.3-1.1-2.1-1.11.1
Bone: cortical porosity2.52.811.93.5-1.7-1.7-2.01.90.8-1.41.6-1.11.21.9-1.0-1.7-0.50.5
Bone: cortical thickness1.62.78.6-0.3-0.4-2.1-0.40.5-0.2-1.50.7-1.31.4-1.42.9-1.52.9-2.8
Bone: cortical thickness2.02.54.80.1-1.5-2.1-1.01.11.1-2.11.2-2.11.7-1.62.2-0.91.7-1.6
Bone: cortical tissue density1.32.110.9-2.30.20.9-0.10.20.8-0.50.6-0.60.9-3.32.5-0.41.7-1.7
Condit. Reinf. active minus inactive responses0.91.13.01.1-1.30.9-0.70.71.3-0.90.5-0.70.30.1-1.30.1-1.71.7
Condit. Reinf. active-inactive response ratio0.80.93.60.4-0.80.8-0.10.10.9-0.30.1-0.3-0.20.3-1.61.0-1.91.9
Condit. Reinf. active responses1.01.32.91.3-1.40.7-1.31.31.7-1.41.2-0.90.9-0.4-0.6-0.7-1.31.2
Condit. Reinf. inactive responses1.31.64.10.8-0.7-0.5-1.71.61.1-1.31.6-0.81.5-1.01.5-2.01.0-1.0
Incentive salience index mean1.01.32.51.3-1.60.7-1.11.01.5-1.40.8-1.20.7-0.4-0.8-0.4-1.51.5
Condit. Reinf. lever presses0.50.81.70.7-1.0-0.0-1.11.11.0-1.31.0-1.01.1-0.90.5-1.1-0.20.1
Condit. Reinf. active minus inactive responses3.24.99.52.9-3.1-1.1-2.62.72.7-3.02.5-2.52.2-0.5-0.4-1.4-1.41.4
Condit. Reinf. active-inactive response ratio2.13.47.32.7-2.6-0.4-1.91.92.0-2.51.7-2.11.5-0.3-0.9-0.8-1.92.0
Condit. Reinf. active responses4.05.711.12.8-3.3-0.6-2.92.93.2-3.22.8-2.62.5-0.8-0.4-1.6-1.51.5
Condit. Reinf. inactive responses1.31.94.40.5-1.50.1-1.81.82.1-1.51.7-1.31.8-1.40.8-1.50.2-0.3
Condit. Reinf. lever presses1.72.56.01.5-2.10.3-1.91.92.4-2.21.8-1.61.6-0.9-0.1-1.0-0.90.9
Condit. Reinf. lever reinforcers received3.65.19.92.5-3.1-0.4-2.82.83.1-3.02.7-2.42.4-0.9-0.2-1.5-1.31.3
Conditioned reinforcement - actives0.10.21.40.60.01.20.1-0.10.30.0-0.10.3-0.30.0-0.20.0-0.70.7
Conditioned reinforcement - inactives0.20.52.91.7-0.5-0.5-0.70.70.1-0.60.6-0.40.60.30.4-1.30.2-0.3
Conditioned locomotion0.40.61.91.0-0.30.60.1-0.20.20.2-0.30.4-0.61.3-1.40.5-1.31.3
Patch foraging indifference point 0 sec1.33.75.71.2-1.5-1.6-2.32.32.0-1.92.4-1.52.3-1.12.0-2.41.9-1.9
Patch foraging indifference point AUC0.20.61.50.4-0.1-1.10.6-0.6-0.30.6-0.50.3-0.51.2-1.00.7-1.11.1
Delay disc. indifference point, 0s delay0.20.20.8-0.2-0.30.9-0.20.20.6-0.20.3-0.0-0.0-0.4-0.50.6-0.70.7
Delay disc. indifference point, 16s delay0.60.91.5-0.30.90.80.9-0.9-1.00.9-1.01.1-1.21.2-1.11.0-0.40.4
Delay disc. indifference point, 2s delay1.31.53.11.2-1.60.1-1.81.71.6-1.21.7-1.11.3-0.6-0.1-0.9-0.50.5
Delay disc. indifference point, 24s delay0.20.30.80.3-0.1-0.30.2-0.20.10.1-0.20.2-0.40.8-0.90.7-0.90.9
Delay disc. indifference point, 4s delay0.20.21.5-0.1-0.11.2-0.10.10.40.20.20.3-0.2-0.1-0.60.5-0.60.7
Delay disc. indifference point, 8s delay0.10.20.6-0.1-0.00.6-0.20.20.3-0.40.3-0.20.2-0.80.5-0.20.6-0.6
Indifference point function ln k0.51.52.80.9-1.2-0.0-1.51.51.1-1.71.2-1.51.4-0.91.0-1.41.1-1.1
Indifference point function log k0.51.52.80.9-1.2-0.0-1.51.51.1-1.71.2-1.51.4-0.91.0-1.41.1-1.1
Patch foraging total patch changes 0 sec1.44.06.71.5-1.5-1.6-2.42.41.9-2.02.4-1.62.4-1.01.9-2.62.0-2.0
Patch foraging total patch changes 12 sec1.82.44.81.1-1.7-0.9-2.02.02.2-1.42.2-1.42.0-1.21.0-1.90.2-0.3
Patch foraging total patch changes 18 sec0.10.30.80.9-0.7-0.9-0.70.70.6-0.30.8-0.20.50.4-0.1-0.40.1-0.1
Patch foraging total patch changes 24 sec0.92.95.01.3-1.5-1.4-2.02.01.6-1.62.2-1.42.0-1.11.7-2.21.5-1.5
Patch foraging total patch changes 6 sec0.50.82.30.6-1.0-1.5-1.01.01.0-0.71.1-0.71.1-0.10.8-1.00.7-0.7
Patch foraging time to switch 0 sec0.00.10.4-0.30.1-0.00.1-0.10.10.0-0.10.6-0.20.1-0.60.6-0.60.6
Patch foraging water rate 0 sec0.10.31.30.50.2-0.3-0.30.3-0.2-0.10.2-0.20.30.40.6-0.71.2-1.1
Patch foraging water rate 12 sec0.10.51.7-0.10.3-0.80.6-0.6-0.90.0-0.60.1-0.40.70.20.61.3-1.2
Patch foraging water rate 18 sec1.22.66.3-0.0-0.4-2.3-1.11.20.3-1.61.3-1.31.5-1.22.5-1.62.5-2.5
Patch foraging water rate 24 sec0.50.82.5-0.60.00.0-0.70.70.4-0.80.9-0.60.7-1.01.2-0.51.6-1.5
Patch foraging water rate 6 sec0.60.81.71.1-1.1-1.0-1.01.00.5-1.20.8-1.31.0-0.20.6-1.00.7-0.6
Seeking ratio, delayed vs. immediate footshock1.82.66.40.51.10.61.3-1.3-1.21.5-1.51.9-1.82.5-2.51.6-1.91.8
Distance traveled before self-admin0.30.62.00.7-1.01.4-0.80.81.2-0.60.7-0.60.5-0.6-0.4-0.1-0.80.8
Distance traveled after self-admin0.10.32.0-0.30.11.40.0-0.00.40.10.10.2-0.20.0-0.70.4-0.60.6
Extensor digitorum longus weight4.718.930.2-3.44.82.65.1-5.2-4.34.9-5.15.4-5.53.7-3.65.2-1.81.8
Bone: elastic displacement0.30.42.60.4-0.8-1.6-0.10.1-0.1-0.7-0.0-0.90.5-0.20.8-0.30.4-0.4
Bone: elastic work1.11.43.01.4-1.5-1.7-1.21.20.8-1.51.0-1.41.3-0.21.0-1.40.5-0.5
Bone: endosteal estimation1.84.313.03.6-1.92.2-2.12.01.8-0.91.7-0.50.51.8-3.2-0.6-2.52.5
Bone: endosteal perimeter2.04.817.74.2-1.82.3-2.12.01.4-0.91.6-0.60.42.1-3.2-1.0-2.82.8
Epididymis fat weight0.10.41.30.60.6-0.40.4-0.4-1.10.1-0.50.7-0.61.2-0.70.2-0.50.5
Delta time in closed arm before/after self-admin2.92.77.3-2.02.3-0.21.4-1.4-2.01.4-1.41.5-0.70.11.5-0.42.7-2.7
Delta time in open arm before/after self-admin1.41.712.20.5-0.63.5-0.20.21.1-0.20.2-0.3-0.2-1.1-0.90.3-2.22.1
Diff in mean of infusions in LGA sessions0.30.51.10.8-0.80.8-0.50.51.0-0.70.5-0.70.4-0.6-0.2-0.2-1.11.0
Delay discount exponential model param0.10.20.9-0.1-0.1-0.9-0.00.0-0.1-0.2-0.0-0.40.4-0.30.6-0.40.5-0.5
Extinction: sum of active levers before priming0.10.11.2-0.10.21.1-0.0-0.00.40.30.00.3-0.1-0.50.5-0.3-0.10.0
Active lever presses in extinction session 61.31.45.02.2-1.01.2-0.60.60.7-0.60.5-0.4-0.10.7-1.3-0.2-2.12.1
Bone: final force2.03.25.81.4-1.4-1.2-2.02.01.2-1.92.1-1.82.2-1.01.9-2.41.9-1.8
Bone: final moment2.54.06.61.5-1.7-1.5-2.22.21.4-2.22.3-2.12.4-1.12.1-2.62.0-2.0
Food consumed during 24 hour testing period0.30.51.90.00.60.00.8-0.9-1.10.8-1.40.6-0.71.2-0.40.1-0.0-0.0
Glucose0.81.22.6-1.41.60.51.2-1.2-1.41.3-1.11.4-1.10.5-0.21.00.7-0.7
Heart weight1.52.47.30.71.7-1.21.6-1.6-2.71.4-1.61.7-1.92.6-0.60.60.4-0.4
Delay discount hyperbolic model param0.10.21.0-0.30.1-1.00.2-0.2-0.30.0-0.2-0.20.2-0.10.6-0.20.6-0.6
Intermittent access intake day 1-15 change0.21.02.9-1.01.70.70.8-0.9-1.51.4-0.91.6-0.90.8-0.30.30.6-0.6
Intermittent access intake escalation0.10.82.3-0.81.50.80.4-0.5-1.11.3-0.51.5-0.60.7-0.2-0.00.7-0.8
Intermittent access intake escalation 20.30.51.6-0.41.30.60.2-0.3-1.11.1-0.41.2-0.40.6-0.2-0.40.6-0.6
Intermitt. access day 1 inactive lever presses0.11.56.52.5-0.92.1-0.90.90.2-1.00.7-0.90.50.1-0.4-1.7-1.21.2
Intermitt. access day 15 inactive lever presses0.73.97.02.5-2.62.3-2.12.22.1-2.32.0-2.31.7-0.9-1.0-1.3-1.61.6
Intermitt. access escalation Index0.31.04.5-0.60.82.11.0-1.0-1.11.1-0.90.8-1.10.4-1.01.0-0.60.6
Intermittent access day 1 total infusions0.20.63.20.9-0.11.80.4-0.40.10.1-0.40.5-0.80.4-0.90.7-1.11.2
Intermittent access day 15 total infusions0.51.37.60.21.02.80.5-0.6-0.61.2-0.71.6-1.11.1-1.40.5-0.70.7
Intermittent access terminal intake (last 3 days)0.81.48.40.90.12.90.1-0.20.10.6-0.31.0-0.71.0-1.80.5-1.61.6
Intermittent access total infusions1.51.75.50.60.72.40.9-0.9-0.61.2-1.11.5-1.41.5-1.80.9-1.51.5
Intermittent access day 1 locomotion0.30.51.91.0-0.20.80.3-0.30.10.2-0.50.3-0.51.4-1.30.2-1.01.0
Intermittent access day 15 total locomotion0.20.72.7-0.10.80.50.7-0.7-0.40.9-0.91.2-0.81.6-1.20.6-0.40.3
Intermittent access total locomotion0.70.93.81.1-0.10.40.2-0.20.10.4-0.50.6-0.51.9-1.80.4-1.31.2
Intermittent access standard deviation0.00.21.20.30.31.1-0.30.3-0.20.00.20.20.2-0.50.4-1.0-0.30.2
Left kidney weight0.21.49.5-0.20.6-3.10.5-0.5-1.60.6-0.60.5-0.21.60.50.01.6-1.5
Right kidney weight0.32.08.90.40.9-3.01.1-1.1-2.21.0-1.31.1-1.02.5-0.20.51.0-0.9
Cocaine induced anxiety0.41.25.3-0.60.8-2.30.4-0.4-1.20.2-0.30.00.1-0.11.5-0.61.8-1.8
Post-drug Anxiety0.91.09.80.40.2-3.10.1-0.1-0.80.0-0.2-0.20.20.70.9-0.61.1-1.1
Baseline Anxiety0.81.44.71.7-1.30.5-0.50.41.0-0.40.3-0.40.01.1-1.80.4-2.22.2
Tail length0.52.89.03.0-2.1-2.6-1.81.81.1-2.01.3-1.71.60.40.5-1.8-0.00.0
Length with tail0.41.912.12.7-0.5-3.5-0.40.3-0.7-0.3-0.10.20.02.9-0.6-0.60.1-0.1
Length without tail0.63.111.30.21.4-2.81.7-1.7-2.51.3-1.81.8-1.63.4-1.11.40.5-0.5
Times rat made contact with spout0.40.51.2-0.20.5-1.10.7-0.7-1.10.3-1.10.0-0.20.20.9-0.40.8-0.8
Lifetime Intake1.01.34.41.20.22.10.5-0.5-0.20.8-0.71.0-1.11.2-1.50.6-1.61.6
Liver weight, left0.61.04.32.1-0.8-2.0-0.70.7-0.2-0.50.4-0.50.61.7-0.7-0.7-0.20.2
Liver weight, right0.61.04.90.4-0.2-2.20.1-0.0-0.9-0.7-0.1-0.90.50.21.4-0.51.7-1.6
Locomotor activity1.32.03.51.9-1.70.2-1.81.81.7-1.51.7-1.51.4-0.6-0.0-1.5-1.01.0
Locomotor testing distance1.22.95.72.1-2.00.9-2.22.22.4-1.62.1-1.41.5-0.7-0.5-1.5-1.41.3
Locomotor testing rearing0.51.85.41.2-1.61.0-1.71.72.3-1.01.7-0.81.1-0.6-0.8-0.7-1.41.4
Locomotion in novel chamber1.01.43.40.6-1.6-1.5-0.90.91.4-0.70.7-1.00.71.0-1.80.9-1.41.4
Locomotion in novel chamber post-restriction0.10.30.90.7-0.2-0.5-0.60.50.2-0.30.4-0.30.60.30.3-1.00.7-0.7
Fecal boli incidents, locomotor time 10.10.20.7-0.10.2-0.3-0.20.2-0.1-0.30.3-0.20.4-0.60.8-0.60.7-0.7
Change in fecal boli incidents, locomotor task0.10.11.50.1-0.2-1.20.0-0.00.00.2-0.00.0-0.00.6-0.10.10.0-0.0
Time >=10cm from walls, locomotor time 10.40.52.3-0.80.1-0.40.9-0.8-0.30.1-0.70.1-0.70.4-0.71.5-0.50.6
Bouts of movement, locomotor time 10.50.61.8-1.30.90.61.0-1.0-1.10.8-0.90.5-0.8-0.20.20.70.4-0.4
Total resting periods, locomotor time 10.70.81.9-1.31.10.11.2-1.2-1.41.0-1.20.6-0.90.10.20.80.4-0.4
Rest time, locomotor task time 10.00.10.3-0.3-0.10.30.2-0.2-0.1-0.1-0.1-0.4-0.1-0.50.20.3-0.20.2
Distance moved, locomotor task time 10.20.62.60.40.3-0.30.4-0.4-0.40.8-0.50.8-0.71.6-1.40.7-0.80.8
Vertical activity count, locomotor time 10.10.52.00.10.30.50.2-0.3-0.30.8-0.40.7-0.71.2-1.40.7-0.70.7
Time >=10cm from walls, locomotor time 20.10.20.60.4-0.8-0.8-0.30.40.4-0.60.3-0.70.40.2-0.30.0-0.30.3
Bouts of movement, locomotor time 20.10.30.50.2-0.6-0.6-0.60.60.4-0.50.6-0.70.6-0.50.7-0.70.6-0.5
Total resting periods, locomotor time 20.00.20.6-0.1-0.2-0.4-0.30.3-0.0-0.20.3-0.40.3-0.40.7-0.40.8-0.7
Rest time, locomotor task time 20.61.02.1-0.81.20.81.4-1.4-1.41.1-1.41.0-1.20.5-0.10.80.3-0.3
Distance moved, locomotor task time 20.10.10.50.3-0.3-0.1-0.30.30.5-0.10.30.00.10.5-0.70.3-0.50.5
Vertical activity count, locomotor time 20.30.71.60.6-1.00.9-1.01.01.3-0.81.1-0.80.7-0.6-0.2-0.4-0.50.5
Light reinforcement 10.42.03.71.2-1.40.1-1.71.81.5-1.61.8-1.41.6-1.41.3-1.90.6-0.6
Light reinforcement 20.81.93.51.0-1.4-0.2-1.81.81.4-1.31.9-1.41.6-1.41.2-1.80.4-0.4
Bone: marrow area1.74.212.73.6-1.82.2-2.12.01.8-0.91.7-0.50.51.8-3.2-0.7-2.42.4
Bone: maximum diameter1.42.98.02.8-1.81.3-2.32.31.6-1.82.2-1.51.5-0.1-0.4-2.0-0.30.3
Bone: maximum force0.91.84.01.8-1.1-0.7-1.81.80.8-1.21.8-0.91.50.30.7-2.01.2-1.2
Bone: maximum moment1.32.44.41.9-1.3-1.1-2.12.01.1-1.52.0-1.21.80.10.8-2.11.3-1.3
Mean time between licks in bursts0.74.310.4-0.72.6-0.32.4-2.4-3.22.4-2.42.5-2.52.6-1.31.7-0.20.2
Mean num. licks in bursts0.41.02.30.2-0.4-0.0-1.11.10.9-0.70.8-0.81.2-1.01.2-1.41.5-1.5
Cd content in liver2.02.27.6-2.82.01.61.7-1.7-0.91.5-1.31.7-1.5-0.5-0.01.7-0.00.0
Co content in liver1.72.06.7-0.5-0.30.11.0-1.00.20.9-1.20.3-1.00.8-2.12.3-2.62.6
Cu content in liver0.40.51.40.9-1.10.10.1-0.00.3-0.8-0.2-1.10.1-0.4-0.40.1-1.21.2
Fe content in liver0.50.72.7-1.60.4-0.60.8-0.7-0.30.6-0.70.1-0.3-0.91.10.61.0-1.0
K content in liver1.71.74.50.7-2.1-0.1-0.91.01.7-1.91.1-2.11.3-1.80.5-0.3-0.90.9
Mg content in liver1.71.99.8-0.7-1.60.5-0.30.51.6-1.90.7-2.31.2-3.11.30.1-0.30.3
Mn content in liver5.25.812.50.7-2.2-1.0-1.92.12.1-2.92.2-3.32.9-3.53.3-2.51.7-1.7
Na content in liver0.91.03.20.2-1.31.1-1.00.91.8-0.51.0-0.70.5-1.3-0.3-0.1-1.41.4
Rb content in liver1.21.43.8-0.2-1.6-0.7-0.70.81.6-1.71.1-1.81.3-2.00.60.1-0.30.4
Se content in liver1.31.63.9-1.81.31.02.0-1.9-1.51.0-1.70.7-1.4-0.70.41.1-0.10.1
Sr content in liver1.21.12.5-0.20.50.61.1-1.1-1.01.1-1.20.7-1.21.3-1.61.5-0.70.8
Zn content in liver0.10.10.4-0.5-0.3-0.40.3-0.20.1-0.4-0.1-0.4-0.0-0.60.30.5-0.30.3
Bone: minimum diameter2.44.520.54.5-2.30.7-2.42.41.6-1.92.0-1.41.41.6-2.0-1.9-1.71.7
Time in familiar zone, hab. session 10.80.82.3-1.01.51.01.0-1.0-0.81.2-0.81.2-1.00.4-0.30.7-0.30.3
Time in novel zone, hab. session 10.20.20.80.5-0.9-0.8-0.30.30.2-0.60.1-0.70.30.1-0.10.10.2-0.1
Total zone transitions, hab. session 11.42.03.5-1.21.80.21.9-1.9-1.61.6-1.81.5-1.51.4-0.81.40.4-0.5
Total locomotion distance, hab. session 10.10.20.70.8-0.2-0.5-0.50.50.2-0.60.5-0.20.40.8-0.4-0.30.2-0.2
Locomotion velocity, hab. session 10.20.30.91.0-0.3-0.4-0.60.60.4-0.60.6-0.10.40.9-0.5-0.40.0-0.0
Time in familiar zone, hab. session 20.91.02.1-1.01.4-0.71.1-1.1-1.21.4-1.01.5-1.11.00.00.6-0.10.1
Time in novel zone, hab. session 21.01.12.30.9-1.5-0.2-1.21.21.0-1.51.1-1.51.2-0.80.2-0.60.6-0.5
Total zone transitions, hab. session 21.31.73.5-1.71.30.01.8-1.8-1.11.4-1.91.2-1.40.8-0.81.9-0.30.3
Total locomotion distance, hab. session 20.50.71.3-1.01.00.11.1-1.1-0.70.7-1.00.8-0.90.5-0.41.1-0.0-0.0
Locomotion velocity, hab. session 20.50.71.3-1.11.10.21.1-1.1-0.80.8-1.00.9-0.90.6-0.41.10.1-0.2
Novel to familiar place preference ratio0.30.51.31.1-0.7-0.1-1.01.00.6-0.70.9-0.40.70.10.0-0.90.2-0.2
Novelty place preference0.40.51.11.0-0.7-0.3-1.01.00.6-0.70.9-0.50.8-0.00.1-0.90.3-0.3
Time in novel zone, NPP test0.40.50.90.9-0.7-0.5-0.90.90.5-0.80.8-0.60.8-0.10.4-0.90.6-0.6
Total zone transitions, NPP test0.40.62.5-1.61.10.30.9-0.9-0.71.0-0.70.6-0.4-0.10.10.80.7-0.7
Total locomotion distance, NPP test0.10.10.4-0.30.0-0.2-0.10.10.1-0.20.2-0.20.4-0.10.3-0.20.6-0.6
Locomotion velocity, NPP test0.00.00.1-0.30.30.30.1-0.1-0.10.1-0.00.20.00.2-0.20.10.2-0.2
Intraocular pressure0.40.61.0-0.30.50.70.8-0.8-0.80.8-0.90.8-1.00.7-0.90.7-1.01.0
Delta distance traveled before/after self-admin0.20.20.6-0.70.80.30.5-0.5-0.50.4-0.40.4-0.30.10.20.00.4-0.5
Delta ambulatory time before/after self-admin0.30.51.4-0.61.2-0.20.6-0.6-0.90.8-0.50.8-0.50.60.3-0.30.7-0.8
Parametrial fat weight0.61.43.90.6-0.9-2.0-1.21.20.5-1.01.2-1.01.4-0.41.3-1.51.1-1.0
Pavlov. Cond. lever latency1.41.75.4-2.31.61.81.6-1.5-0.81.3-1.31.1-1.2-0.80.41.20.7-0.7
Pavlov. Cond. magazine entry latency4.15.38.72.4-2.7-2.4-2.92.92.5-2.72.8-2.42.8-0.91.1-2.60.2-0.2
Pavlov. Cond. change in total contacts1.92.04.01.9-2.0-0.7-1.61.61.6-1.91.3-1.81.5-0.70.1-1.4-0.90.9
Pavlov. Cond. index score2.73.46.02.4-2.2-1.7-2.52.41.8-2.22.2-1.82.1-0.30.4-2.1-0.30.2
Pavlov. Cond. latency score2.22.85.62.4-2.0-2.0-2.22.11.5-2.01.9-1.61.90.00.3-1.8-0.30.3
Pavlov. Cond. lever contacts1.41.74.92.2-1.7-1.6-1.61.61.0-1.41.3-1.11.20.6-0.4-1.2-0.90.8
Pavlov. Cond. magazine entry number4.96.310.1-2.22.91.93.2-3.2-2.93.1-3.12.7-3.11.6-1.62.8-0.50.5
Pavlov. Cond. intertrial magazine entries0.70.84.1-0.00.82.00.7-0.7-0.40.6-0.70.9-1.00.3-0.90.4-1.21.1
Pavlov. Cond. lever-magazine prob. diff.3.13.96.92.6-2.4-1.7-2.62.62.0-2.42.3-2.02.2-0.30.3-2.1-0.40.4
Pavlov. Cond. response bias5.26.511.12.8-3.1-2.2-3.33.32.8-3.13.1-2.73.0-1.01.0-2.80.1-0.1
Pavlov. Cond. lever latency0.60.81.7-0.81.30.11.0-1.0-1.31.3-1.01.1-0.90.6-0.10.50.5-0.5
Pavlov. Cond. magazine entry latency0.30.51.2-0.90.70.60.8-0.8-0.40.8-0.60.8-0.80.2-0.51.1-0.30.3
Pavlov. Cond. change in total contacts0.61.54.30.8-1.80.3-0.80.82.0-1.00.8-1.10.6-0.5-1.00.3-2.12.0
Pavlov. Cond. index score0.20.41.00.4-0.90.5-0.30.41.0-0.70.4-0.50.3-0.2-0.70.3-1.01.0
Pavlov. Cond. latency score0.20.40.90.5-0.90.5-0.40.40.9-0.60.4-0.50.2-0.1-0.70.2-0.91.0
Pavlov. Cond. lever contacts0.60.81.80.7-1.3-0.2-1.01.01.3-1.41.0-1.21.0-0.80.3-0.6-0.40.4
Pavlov. Cond. magazine entry number0.10.20.90.9-0.3-0.1-0.40.4-0.1-0.30.1-0.30.30.3-0.0-0.8-0.30.2
Pavlov. Cond. intertrial magazine entries0.81.76.72.6-1.40.3-1.41.30.7-1.30.8-1.11.10.5-0.9-1.7-1.31.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.80.3-0.70.5-0.20.20.8-0.50.2-0.40.1-0.1-0.70.5-0.90.9
Pavlov. Cond. response bias0.40.51.30.3-1.0-0.2-0.80.81.1-1.00.8-0.90.9-0.90.4-0.4-0.10.1
Time in closed arm before self-admin0.61.04.4-0.60.2-1.2-0.10.20.2-0.70.5-0.60.7-1.52.1-0.71.6-1.6
Time in closed arm after self-admin3.23.610.3-3.12.4-0.91.4-1.4-1.71.1-1.11.2-0.5-0.92.5-0.13.2-3.2
Time in open arm before self-admin2.53.18.5-0.61.6-0.61.7-1.7-2.01.9-1.82.0-2.12.9-2.12.1-0.50.6
Time in open arm after self-admin2.32.69.11.7-0.41.60.3-0.40.00.6-0.70.6-1.11.9-2.81.1-3.03.0
Bone: periosteal estimation1.94.515.33.9-2.41.0-2.82.82.0-2.22.5-1.71.70.8-1.3-2.1-0.90.9
Bone: periosteal perimeter1.12.210.13.2-1.60.7-1.81.71.0-1.11.4-0.70.71.4-1.6-1.1-1.21.2
Bone: post-yield work0.81.48.01.50.40.10.1-0.2-0.90.9-0.41.1-1.02.8-2.20.5-0.90.9
Progressive ratio test 1 active lever presses0.61.15.31.5-0.82.3-0.30.30.7-0.30.10.0-0.20.4-1.40.2-1.61.6
Progressive ratio test 1 breakpoint0.61.15.61.7-0.82.4-0.40.40.7-0.30.10.0-0.10.4-1.3-0.1-1.51.6
Progressive ratio test 1 inactive lever presses0.61.65.82.4-1.41.6-1.21.10.9-1.20.9-1.00.7-0.2-0.3-1.4-1.31.3
Progressive ratio test 2 active lever presses0.81.13.41.4-0.81.9-0.40.40.7-0.30.2-0.1-0.10.7-1.60.1-1.81.8
Progressive ratio test 2 breakpoint0.91.23.71.5-0.81.9-0.50.50.8-0.30.2-0.1-0.00.7-1.70.1-1.81.8
Progressive ratio test 2 inactive lever presses0.30.94.42.0-0.52.1-0.30.30.1-0.30.1-0.1-0.10.4-0.8-0.7-1.41.4
Incentive Sensitization - Responses0.51.34.11.1-1.20.6-0.80.81.0-0.50.7-0.50.30.9-2.00.4-1.91.9
Incentive Sensitization - Breakpoint0.61.34.21.0-1.20.7-0.80.81.0-0.50.6-0.40.30.9-2.00.5-1.91.9
Sum of active levers in priming session hrs 5-61.51.45.7-0.4-0.52.40.0-0.00.90.10.00.2-0.5-0.5-1.51.4-2.22.2
Progressive ratio0.10.31.1-0.0-0.31.1-0.70.70.9-0.40.7-0.30.7-0.80.1-0.6-0.10.0
Food seeking constrained by brief footshock0.30.41.8-0.00.11.00.2-0.20.10.3-0.30.2-0.20.4-1.00.2-1.31.3
Seeking ratio, punishment vs. effort0.20.41.40.4-0.10.20.5-0.5-0.30.4-0.50.2-0.60.8-0.80.5-1.21.2
Retroperitoneal fat weight0.10.55.40.4-0.1-2.3-0.20.2-0.2-0.70.2-0.20.40.70.2-0.10.4-0.4
Reaction time number correct0.00.10.40.40.30.10.3-0.3-0.60.1-0.50.1-0.50.4-0.10.2-0.10.1
Reaction time mean minus median0.00.30.70.4-0.70.8-0.20.20.5-0.60.0-0.80.4-0.70.0-0.5-0.80.8
Reaction time mean minus median AUC0.10.93.40.1-1.10.9-0.60.71.1-1.20.6-1.51.0-1.81.0-0.9-0.00.0
Reaction time num false alarms0.10.20.90.80.10.90.0-0.1-0.40.6-0.40.2-0.30.6-0.4-0.6-0.10.1
Reaction time num false alarms AUC0.10.20.90.9-0.10.7-0.30.2-0.30.2-0.2-0.10.10.4-0.2-1.0-0.00.0
Reaction time trials correct on left0.00.10.40.40.30.10.3-0.3-0.60.1-0.50.1-0.50.4-0.10.2-0.10.1
Reaction time trials on left0.00.10.30.50.10.10.2-0.2-0.5-0.1-0.4-0.1-0.40.3-0.10.1-0.10.1
Reaction time mean0.61.43.00.5-1.70.5-0.90.91.7-1.40.9-1.61.2-1.70.4-0.6-1.01.0
Reaction time mean AUC0.51.33.60.3-1.51.0-0.70.81.7-1.30.9-1.51.1-1.90.4-0.5-1.11.1
Median of all reaction times1.01.53.30.7-1.80.4-1.01.01.8-1.41.1-1.71.2-1.70.3-0.6-1.11.1
Reaction time omissions3.45.510.91.9-3.3-0.1-2.82.83.1-2.92.6-3.22.8-2.00.7-2.0-0.60.6
Reaction time false alarm rate0.10.20.80.6-0.20.9-0.30.3-0.00.20.0-0.00.20.1-0.2-0.9-0.10.0
Reaction time premature initiation rate0.30.41.50.5-0.5-0.8-0.90.80.3-0.20.7-0.30.70.10.5-1.20.4-0.5
Reaction time premature initiations0.10.31.60.7-0.4-0.5-0.80.70.2-0.20.5-0.30.50.20.4-1.30.4-0.4
Std. dev. reaction times0.41.23.50.2-1.40.6-0.80.81.4-1.40.7-1.71.3-1.90.7-0.9-0.50.5
Reaction time trials completed0.00.10.30.50.10.10.2-0.2-0.5-0.1-0.4-0.1-0.40.3-0.10.1-0.10.1
Reaction time trials AUC0.00.10.20.40.10.20.2-0.2-0.4-0.0-0.4-0.1-0.40.3-0.10.1-0.10.1
Run reversals in cocaine runway, females1.11.33.7-0.71.2-0.31.2-1.3-1.91.2-1.41.1-1.31.5-1.00.9-0.00.1
Run reversals in cocaine runway, males0.50.52.00.9-0.6-1.4-0.80.80.1-0.40.8-0.50.80.40.3-0.90.6-0.6
Latency to leave start box in cocaine runway0.70.91.9-0.71.2-1.00.9-0.9-1.31.3-1.01.4-0.91.2-0.20.60.5-0.4
Latency to leave start box in cocaine runway, F3.03.87.4-1.02.3-0.01.9-2.0-2.72.6-2.12.7-2.32.5-1.51.8-0.00.1
Latency to leave start box in cocaine runway, M2.01.93.30.3-1.3-1.5-1.31.41.8-1.51.4-1.61.8-1.71.7-1.30.6-0.7
Std. dev. time between licks in bursts0.40.81.3-0.20.90.40.8-0.8-0.81.0-0.71.1-1.21.1-1.11.1-0.80.8
Total sessions with >9 infusions1.92.34.80.60.82.21.4-1.4-0.91.5-1.51.6-2.01.6-1.81.7-1.61.6
Short access day 1 total inactive lever presses0.30.62.11.4-1.0-0.7-0.50.50.5-0.30.4-0.40.11.1-0.90.3-0.91.0
Short access day 10 total inactive lever presses0.11.04.02.0-1.11.0-1.01.00.5-1.00.8-1.10.8-0.1-0.2-1.3-0.70.7
Short access day 1 total infusions0.40.86.01.5-0.62.4-0.30.30.5-0.20.4-0.1-0.2-0.5-0.1-0.1-1.01.0
Short access day 10 total infusions0.40.62.01.1-0.11.40.2-0.3-0.10.3-0.40.6-0.70.8-1.00.4-1.21.2
Short access total infusions0.50.73.41.4-0.31.90.2-0.20.00.2-0.20.3-0.70.4-0.70.3-1.31.3
Short access day 1 locomotion0.40.72.81.7-0.81.6-0.40.30.7-0.10.3-0.0-0.20.7-1.00.1-1.01.0
Short access day 10 total locomotion0.20.93.51.9-0.80.3-0.50.50.6-0.40.1-0.30.31.4-1.3-0.7-1.61.5
Short access total locomotion1.11.74.52.1-0.31.60.3-0.3-0.10.4-0.70.6-0.92.1-2.10.3-2.01.9
One hour access (0.3 mA shock)0.40.51.80.00.41.30.1-0.2-0.10.6-0.30.8-0.50.9-1.30.6-0.70.7
Compulsive drug intake0.20.44.1-0.7-0.1-2.0-0.10.10.1-0.00.2-0.30.30.20.10.40.5-0.5
One hour access (shock baseline)0.51.34.00.50.72.00.7-0.8-0.61.0-1.01.2-1.11.4-1.80.8-1.31.3
Social response proportion1.51.95.70.50.7-1.21.6-1.6-2.01.3-1.90.8-1.52.4-1.21.0-0.70.7
Social responses0.10.21.00.7-0.2-1.0-0.10.1-0.3-0.1-0.1-0.10.10.60.3-0.60.4-0.4
Social time0.81.23.61.9-0.5-0.70.6-0.6-0.80.0-0.8-0.1-0.81.6-1.40.4-1.91.9
Soleus weight0.41.22.90.20.80.21.1-1.1-1.50.8-1.30.8-1.31.7-1.51.1-0.80.9
Bone: stiffness0.10.20.8-0.10.40.6-0.40.40.10.20.50.40.20.20.2-0.60.9-0.9
Tibialis anterior weight0.72.54.50.11.20.61.7-1.7-1.51.2-1.91.4-1.92.1-2.01.7-1.61.6
Time to tail flick, vehicle, before self-admin0.20.31.8-1.30.1-0.40.00.0-0.1-0.10.1-0.10.3-0.70.40.40.8-0.8
Time to tail flick, vehicle, after self-admin0.30.51.30.7-0.80.1-0.90.80.9-0.70.8-0.70.9-0.70.7-1.10.0-0.1
Time to tail flick, test, before self-admin1.21.43.8-1.00.80.41.6-1.5-1.00.8-1.40.6-1.40.7-1.21.9-1.11.2
Time to tail flick, test, after self-admin0.10.10.8-0.0-0.10.90.1-0.1-0.1-0.2-0.1-0.3-0.1-0.4-0.10.0-0.60.6
Delta time to tail flick, vehicle, before/after SA0.91.03.51.9-1.20.4-1.11.11.0-1.00.9-0.90.9-0.1-0.2-1.2-0.80.7
Delta time to tail flick, test, before/after SA0.70.91.71.3-1.30.2-1.31.21.2-1.01.1-1.00.9-0.4-0.0-0.9-0.50.5
Tibia length1.02.99.5-0.71.7-2.70.6-0.7-2.10.5-0.71.0-0.20.92.2-1.03.1-3.1
Ambulatory time before self-admin0.20.81.81.0-1.11.3-0.90.91.3-0.70.8-0.70.7-0.7-0.3-0.3-0.70.8
Ambulatory time after self-admin0.10.10.30.4-0.20.3-0.40.40.5-0.20.5-0.10.4-0.10.2-0.50.2-0.2
Bone: tissue strength1.11.13.3-1.21.4-0.90.5-0.5-1.21.0-0.20.9-0.2-0.21.5-0.51.8-1.8
Total heroin consumption1.72.04.01.4-2.00.9-1.61.62.0-1.41.6-1.41.1-0.9-0.7-0.3-1.71.7
Bone: trabecular number2.85.48.02.5-2.7-2.5-2.82.82.0-2.62.6-2.52.8-0.91.6-2.80.9-0.9
Bone: trabecular spacing1.82.64.7-1.51.91.51.9-1.9-1.42.2-1.92.0-1.80.9-1.31.6-0.90.8
Bone: trabecular thickness0.50.82.31.5-1.0-0.9-1.01.00.3-0.80.8-0.70.70.60.3-1.10.8-0.8
Bone: trabecular tissue density0.40.72.1-0.70.1-0.9-0.40.4-0.1-0.10.6-0.20.7-0.91.4-0.71.4-1.4
Water consumed over 24 hours0.30.71.8-0.60.6-0.50.6-0.6-1.20.1-0.9-0.1-0.0-0.31.3-0.51.3-1.3
Number of responses in last shaping day0.30.42.61.6-0.10.8-0.30.2-0.60.40.00.4-0.31.1-0.6-0.7-0.20.3