Hub : Genes

Flacc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Flacc1	0.04	0.03	5.6e-03	0.03	0.01	0.02	0.03	1.8e-04	8.0e-03	9.0e-04	4.4e-04
2	Liver	gene expression	Flacc1	0.14	0.07	1.8e-06	0.06	0.05	0.06	0.06	7.7e-07	2.1e-06	1.0e-06	5.2e-07
3	Liver	intron excision ratio	chr9_67810932_67816288	0.06	0.03	8.1e-06	0.01	0.04	0.03	0.03	1.7e-02	3.3e-05	1.4e-04	6.4e-04
4	Adipose	gene expression	Flacc1	0.07	0.04	6.1e-05	0.01	0.03	0.03	0.01	2.7e-02	8.1e-04	4.7e-04	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.6	2.9	4.8	-1.7	0.1	2.2	-1.9
Area under the delay curve	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.4
BMI with tail	3.6	12.7	24.0	4.9	-4.5	-2.5	-0.2
BMI without tail	0.5	2.8	6.8	1.9	-2.6	-0.6	0.6
Body weight	0.1	0.3	0.7	-0.7	-0.2	0.9	-0.2
Weight adjusted by age	0.4	1.1	1.8	-1.0	0.4	1.3	-1.2
Bone surface	1.9	3.6	7.2	-2.7	0.9	1.9	-1.7
Bone volume	1.7	3.3	5.6	-2.4	0.7	2.0	-1.8
Breakpoint value in progressive ratio session	0.4	0.7	0.9	-0.8	0.8	0.7	-0.9
Number of licking bursts	0.1	0.4	0.6	-0.4	0.6	0.5	-0.8
Context. condit. distance diff. score	0.9	1.1	3.5	0.6	0.6	0.5	1.9
Locomotion velocity, session 1	1.6	1.8	4.9	1.1	-0.5	-0.9	2.2
Locomotion distance, session 1	0.4	0.6	0.9	0.9	-1.0	0.4	0.5
Locomotion velocity, session 2	0.5	0.5	0.9	0.6	-1.0	-0.1	1.0
Locomotion distance, session 2	1.1	1.5	5.1	0.7	-2.3	-0.4	0.4
Locomotion velocity, session 3	0.8	0.9	2.6	0.6	-0.7	0.4	1.6
Locomotion distance, session 3	0.3	0.3	0.6	-0.6	0.4	0.6	0.8
Stereotopy head waving bouts, day 3	0.6	0.7	1.4	1.2	-0.5	-1.0	-0.4
Stereotopy head waving duration, day 3	1.1	1.4	2.4	1.6	-1.5	-0.8	-0.6
Locomotion velocity, session 7	1.0	1.1	2.2	1.5	-0.9	-0.9	0.9
Locomotion distance, session 7	0.4	0.5	1.4	0.3	-0.3	-0.6	1.2
Stereotopy head waving bouts, day 7	0.9	1.1	2.3	-1.1	0.8	1.5	-0.2
Stereotopy head waving duration, day 7	0.4	0.5	1.4	-0.2	-0.6	1.2	-0.3
Locomotion velocity, session 8	0.5	0.6	1.9	0.2	-0.1	0.8	1.4
Locomotion distance, session 8	0.5	0.7	2.4	0.4	-0.3	0.5	1.5
Degree of sensitization distance	0.3	0.4	0.6	0.8	-0.6	-0.7	0.0
Degree of sensitization stereotypy	1.5	1.6	3.8	-1.5	0.4	2.0	0.4
Conditioned locomotion	0.4	0.5	1.5	-1.2	0.3	0.1	0.6
Cocaine response after cond. corrected	1.0	1.5	2.2	-1.5	1.1	1.3	1.1
Cocaine response after cond. not corrected	2.0	2.9	4.7	-2.1	1.5	2.2	-0.6
Cocaine response before conditioning	2.8	3.4	11.4	-0.7	0.5	1.2	-3.4
Saline control response	0.3	0.5	1.1	-0.5	0.1	1.0	-0.7
Bone: connectivity density	1.6	2.6	5.2	-1.0	-1.0	1.7	-2.3
Bone: cortical apparent density	2.5	3.9	8.8	2.4	-0.3	-3.0	1.0
Bone: cortical area	0.6	1.0	1.9	-1.1	1.4	-1.0	-0.2
Bone: cortical porosity	2.7	2.9	4.8	-2.1	2.2	1.3	-0.6
Bone: cortical porosity	3.9	4.3	6.9	-2.6	2.3	1.8	-1.3
Bone: cortical thickness	0.9	1.5	5.4	0.8	0.3	-2.3	0.2
Bone: cortical thickness	0.4	0.5	1.1	1.0	-0.1	-0.9	-0.6
Bone: cortical tissue density	2.6	4.1	8.7	2.5	-0.4	-3.0	1.0
Condit. Reinf. active minus inactive responses	1.3	1.5	2.9	-0.8	1.4	0.5	-1.7
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.5	-0.2	0.6	0.1	-1.2
Condit. Reinf. active responses	1.6	2.0	2.9	-1.6	1.7	0.9	-1.4
Condit. Reinf. inactive responses	0.3	0.4	1.0	-1.0	0.8	0.2	0.1
Incentive salience index mean	2.1	2.7	4.8	-1.4	1.9	0.9	-2.2
Condit. Reinf. lever presses	1.1	1.6	3.0	-1.3	1.7	0.8	-1.1
Condit. Reinf. active minus inactive responses	2.3	3.5	4.8	-2.2	2.0	2.0	-1.1
Condit. Reinf. active-inactive response ratio	1.6	2.5	4.5	-1.3	2.1	1.6	-1.1
Condit. Reinf. active responses	2.2	3.1	4.8	-2.2	2.1	1.6	-1.0
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.9	0.5	-0.0	-0.2
Condit. Reinf. lever presses	0.6	0.8	2.0	0.2	1.1	-0.0	-1.4
Condit. Reinf. lever reinforcers received	2.3	3.2	4.6	-2.1	2.1	1.6	-1.1
Conditioned reinforcement - actives	0.1	0.3	0.6	0.6	-0.2	-0.8	-0.5
Conditioned reinforcement - inactives	0.4	1.1	2.8	-0.8	1.7	-1.0	0.2
Conditioned locomotion	0.6	0.9	1.3	1.0	-1.1	-1.1	0.3
Patch foraging indifference point 0 sec	0.2	0.4	0.8	0.7	-0.3	-0.9	-0.7
Patch foraging indifference point AUC	0.3	0.7	1.2	-0.8	1.1	0.1	-1.0
Delay disc. indifference point, 0s delay	1.6	1.8	3.8	1.6	-1.9	-0.8	-0.0
Delay disc. indifference point, 16s delay	0.5	0.7	1.4	-0.8	0.6	1.2	-0.5
Delay disc. indifference point, 2s delay	0.8	0.9	2.1	1.1	-1.4	-0.4	0.3
Delay disc. indifference point, 24s delay	0.2	0.3	1.1	-0.3	-0.1	-0.0	-1.1
Delay disc. indifference point, 4s delay	0.6	0.6	0.9	0.8	-0.6	-0.7	1.0
Delay disc. indifference point, 8s delay	0.3	0.5	1.6	-1.3	0.5	0.4	0.4
Indifference point function ln k	0.1	0.3	0.7	0.3	-0.6	0.3	0.9
Indifference point function log k	0.1	0.3	0.7	0.3	-0.6	0.3	0.9
Patch foraging total patch changes 0 sec	0.2	0.7	1.1	1.0	-0.4	-0.8	-1.1
Patch foraging total patch changes 12 sec	0.4	0.5	1.0	0.3	0.5	-1.0	-0.9
Patch foraging total patch changes 18 sec	0.8	1.9	3.3	1.6	-0.6	-1.8	-1.2
Patch foraging total patch changes 24 sec	0.2	0.6	1.5	-0.4	0.9	0.1	-1.2
Patch foraging total patch changes 6 sec	0.6	1.0	3.3	0.5	-0.8	-0.2	-1.8
Patch foraging time to switch 0 sec	0.1	0.3	0.8	0.7	-0.9	-0.2	-0.1
Patch foraging water rate 0 sec	0.1	0.3	0.6	-0.8	0.7	0.2	0.2
Patch foraging water rate 12 sec	0.1	0.5	1.5	-0.1	-0.6	1.2	-0.5
Patch foraging water rate 18 sec	0.3	0.6	0.9	-0.5	0.7	0.8	-0.9
Patch foraging water rate 24 sec	0.3	0.5	1.3	-0.3	-0.7	1.2	-0.1
Patch foraging water rate 6 sec	0.1	0.1	0.4	0.2	-0.6	0.1	0.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	2.9	-1.0	-0.5	1.7	-0.6
Distance traveled before self-admin	0.8	1.8	3.6	-1.9	1.1	1.3	-0.8
Distance traveled after self-admin	0.1	0.2	0.3	-0.6	-0.2	-0.1	-0.5
Extensor digitorum longus weight	1.5	5.9	11.0	2.4	-3.3	-2.6	-0.3
Bone: elastic displacement	0.3	0.4	0.6	0.7	-0.2	0.6	-0.8
Bone: elastic work	0.2	0.3	0.9	-0.2	0.1	0.4	-1.0
Bone: endosteal estimation	1.7	4.3	7.0	-2.6	2.0	1.8	-1.8
Bone: endosteal perimeter	1.4	3.5	6.7	-2.6	1.6	1.9	-1.2
Epididymis fat weight	0.1	0.5	0.7	-0.7	-0.8	-0.2	0.8
Delta time in closed arm before/after self-admin	0.3	0.2	0.4	-0.5	0.6	0.4	-0.4
Delta time in open arm before/after self-admin	3.6	4.2	7.3	-2.7	2.6	1.6	-0.3
Diff in mean of infusions in LGA sessions	1.1	2.0	3.8	-0.6	0.4	1.9	-2.0
Delay discount exponential model param	0.0	0.0	0.0	0.1	0.1	0.0	-0.2
Extinction: sum of active levers before priming	0.3	0.5	1.2	-0.5	0.2	0.7	-1.1
Active lever presses in extinction session 6	0.5	0.5	0.9	-0.6	0.9	0.2	0.9
Bone: final force	0.9	1.5	2.7	-1.6	1.1	0.0	-1.4
Bone: final moment	0.7	1.2	2.9	-1.1	0.7	-0.1	-1.7
Food consumed during 24 hour testing period	0.5	1.0	2.1	1.4	-1.0	-1.0	-0.0
Glucose	0.9	1.4	2.5	1.4	-1.6	-1.0	-0.3
Heart weight	1.3	2.2	3.5	-1.5	0.2	1.7	-1.9
Delay discount hyperbolic model param	0.0	0.1	0.2	0.1	0.2	0.2	-0.4
Intermittent access intake day 1-15 change	0.1	0.7	1.6	0.9	-0.7	0.1	-1.3
Intermittent access intake escalation	0.2	1.1	2.5	1.1	-0.9	-0.1	-1.6
Intermittent access intake escalation 2	0.4	0.7	1.5	-0.2	0.2	1.0	-1.2
Intermitt. access day 1 inactive lever presses	0.3	3.5	6.4	2.5	-1.5	-2.3	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.8	2.3	0.7	-0.5	-0.5	-1.5
Intermitt. access escalation Index	0.5	1.7	3.6	1.0	-0.9	-1.9	1.2
Intermittent access day 1 total infusions	0.1	0.3	0.4	0.6	0.5	-0.7	0.4
Intermittent access day 15 total infusions	0.7	1.8	3.5	1.9	-0.8	-1.4	-1.0
Intermittent access terminal intake (last 3 days)	0.9	1.6	3.4	1.9	-0.7	-1.1	-1.1
Intermittent access total infusions	0.8	1.0	2.1	1.4	-0.4	-1.2	-0.6
Intermittent access day 1 locomotion	0.3	0.6	1.4	0.9	0.3	-1.2	-0.1
Intermittent access day 15 total locomotion	0.1	0.5	1.2	0.5	-0.1	-0.6	-1.1
Intermittent access total locomotion	0.5	0.6	1.3	1.1	-0.4	-0.9	-0.1
Intermittent access standard deviation	0.1	0.3	1.2	1.1	0.2	0.0	-0.2
Left kidney weight	0.3	2.5	4.8	0.7	-2.1	-0.2	-2.2
Right kidney weight	0.3	2.2	6.4	0.2	-2.5	0.3	-1.5
Cocaine induced anxiety	0.1	0.3	0.7	-0.1	-0.9	-0.7	0.2
Post-drug Anxiety	0.4	0.4	0.9	-0.1	-1.0	0.3	0.8
Baseline Anxiety	0.6	1.0	2.4	-0.2	0.3	1.6	1.1
Tail length	2.3	12.5	28.6	-5.3	3.5	2.9	0.7
Length with tail	3.5	15.5	31.1	-5.6	4.2	3.6	-0.1
Length without tail	1.0	5.1	8.1	-2.8	2.2	2.3	-1.5
Times rat made contact with spout	1.0	1.1	1.7	1.3	-1.0	-0.8	1.1
Lifetime Intake	0.9	1.2	2.7	1.6	-0.7	-1.2	-0.5
Liver weight, left	0.6	1.0	2.0	-1.4	0.8	0.7	0.9
Liver weight, right	1.8	3.1	6.8	-1.3	0.3	1.9	-2.6
Locomotor activity	0.5	0.8	1.4	0.7	-1.1	-1.2	-0.3
Locomotor testing distance	0.7	1.7	2.7	1.3	-1.6	-1.0	-1.3
Locomotor testing rearing	0.0	0.0	0.1	0.0	-0.2	-0.2	0.3
Locomotion in novel chamber	2.9	3.9	9.3	2.0	-1.5	0.4	-3.1
Locomotion in novel chamber post-restriction	0.3	0.9	2.6	-0.6	0.6	0.7	-1.6
Fecal boli incidents, locomotor time 1	0.3	0.7	0.8	-0.7	0.9	0.9	-0.9
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	0.7	-0.7	-0.8	0.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.4	0.6	-0.6	0.0
Bouts of movement, locomotor time 1	0.7	0.9	3.6	-0.1	1.9	-0.3	-0.0
Total resting periods, locomotor time 1	0.9	1.0	2.5	0.7	1.6	-1.0	0.5
Rest time, locomotor task time 1	2.1	3.3	6.6	1.5	0.4	-2.6	2.1
Distance moved, locomotor task time 1	0.9	2.7	6.2	-2.5	0.5	1.9	-0.9
Vertical activity count, locomotor time 1	0.1	0.8	1.8	-1.4	0.3	1.1	-0.0
Time >=10cm from walls, locomotor time 2	0.2	0.6	2.0	0.2	-1.4	-0.4	0.1
Bouts of movement, locomotor time 2	0.0	0.2	0.2	0.2	-0.4	0.4	-0.5
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.3	-0.1	0.2	-0.5
Rest time, locomotor task time 2	1.2	2.0	4.1	1.1	0.9	-2.0	1.4
Distance moved, locomotor task time 2	0.6	0.8	1.1	-1.0	-0.7	0.8	-1.0
Vertical activity count, locomotor time 2	0.9	2.2	6.4	1.3	-2.5	-0.7	-0.5
Light reinforcement 1	1.3	5.9	9.6	2.9	-3.1	-2.3	0.4
Light reinforcement 2	0.1	0.2	0.6	-0.1	-0.8	-0.2	-0.2
Bone: marrow area	1.7	4.2	6.9	-2.6	2.0	1.7	-1.8
Bone: maximum diameter	1.4	2.8	6.0	-2.2	2.5	0.3	0.1
Bone: maximum force	0.9	1.9	4.3	-1.6	0.5	0.6	-2.1
Bone: maximum moment	0.9	1.7	5.5	-1.0	0.0	0.5	-2.3
Mean time between licks in bursts	0.4	2.3	3.2	1.0	-1.4	-1.8	1.7
Mean num. licks in bursts	0.7	1.9	2.0	1.4	-1.4	-1.4	1.3
Cd content in liver	0.2	0.2	0.6	-0.0	0.2	0.0	0.8
Co content in liver	0.9	1.1	2.5	0.1	1.6	0.3	1.3
Cu content in liver	0.2	0.2	0.4	-0.6	0.2	-0.1	-0.7
Fe content in liver	1.3	1.6	2.9	-0.8	0.7	1.7	-1.5
K content in liver	0.8	0.8	1.3	-1.1	1.2	0.2	0.7
Mg content in liver	0.3	0.3	0.5	-0.7	0.7	0.4	-0.1
Mn content in liver	1.7	1.9	3.5	1.9	-0.0	-1.8	1.0
Na content in liver	1.2	1.3	2.9	-1.7	1.4	0.7	-0.4
Rb content in liver	0.3	0.4	0.7	-0.7	-0.1	0.6	0.8
Se content in liver	0.1	0.1	0.3	-0.4	0.2	0.1	-0.5
Sr content in liver	0.7	0.6	1.5	0.3	0.1	-1.2	0.8
Zn content in liver	0.1	0.2	0.7	-0.0	-0.1	-0.8	0.1
Bone: minimum diameter	0.9	1.7	3.0	-1.4	1.2	-0.2	-1.7
Time in familiar zone, hab. session 1	0.7	0.8	2.6	0.1	-0.6	1.6	-0.5
Time in novel zone, hab. session 1	0.8	0.9	1.7	-0.1	0.9	-1.3	0.9
Total zone transitions, hab. session 1	0.6	0.9	1.7	-1.1	0.8	1.3	0.2
Total locomotion distance, hab. session 1	1.3	1.9	2.6	-1.4	1.6	1.3	-1.1
Locomotion velocity, hab. session 1	1.0	1.4	1.8	-1.3	1.4	0.9	-1.2
Time in familiar zone, hab. session 2	0.3	0.4	1.0	0.6	0.2	0.2	-1.0
Time in novel zone, hab. session 2	0.5	0.5	0.9	0.3	-0.7	-0.8	1.0
Total zone transitions, hab. session 2	0.3	0.4	0.9	0.5	-1.0	0.2	0.5
Total locomotion distance, hab. session 2	0.3	0.4	1.4	0.5	-1.2	0.2	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	1.2	0.5	-1.1	-0.0	-0.1
Novel to familiar place preference ratio	0.1	0.1	0.4	0.1	-0.7	0.0	0.3
Novelty place preference	0.1	0.1	0.4	0.2	-0.6	-0.0	0.1
Time in novel zone, NPP test	0.1	0.2	0.5	0.2	-0.7	0.1	-0.1
Total zone transitions, NPP test	0.1	0.2	0.4	-0.3	0.4	0.7	0.1
Total locomotion distance, NPP test	0.5	0.8	2.5	0.2	-0.2	0.7	-1.6
Locomotion velocity, NPP test	0.4	0.6	2.1	0.4	-0.2	0.2	-1.4
Intraocular pressure	2.1	3.4	6.6	2.6	-1.8	-1.9	-0.2
Delta distance traveled before/after self-admin	1.0	1.1	1.8	1.1	-1.2	-1.3	0.1
Delta ambulatory time before/after self-admin	0.8	1.4	3.3	1.1	-0.8	-1.8	0.6
Parametrial fat weight	0.9	2.1	2.9	1.3	-1.0	-1.7	1.7
Pavlov. Cond. lever latency	1.3	1.7	2.3	1.3	-1.5	-1.4	0.9
Pavlov. Cond. magazine entry latency	1.9	2.4	4.8	-1.2	1.4	1.2	-2.2
Pavlov. Cond. change in total contacts	1.7	1.8	3.6	-1.0	1.1	1.2	-1.9
Pavlov. Cond. index score	2.2	2.7	4.1	-1.4	2.0	1.5	-1.6
Pavlov. Cond. latency score	2.4	3.1	4.2	-1.6	2.0	1.7	-1.6
Pavlov. Cond. lever contacts	1.2	1.4	2.0	-0.9	1.4	1.2	-1.2
Pavlov. Cond. magazine entry number	1.7	2.1	3.7	1.3	-1.3	-1.2	1.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.4	0.1	0.5	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.6	-1.2	1.9	1.3	-1.6
Pavlov. Cond. response bias	2.0	2.4	3.7	-1.4	1.9	1.2	-1.6
Pavlov. Cond. lever latency	0.4	0.6	1.5	-0.2	-1.2	0.2	1.0
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	0.4	0.9	-0.4	0.2
Pavlov. Cond. change in total contacts	0.9	2.1	7.2	-1.1	2.7	0.2	-0.3
Pavlov. Cond. index score	0.6	1.0	3.8	-0.1	2.0	-0.3	-0.3
Pavlov. Cond. latency score	0.6	0.9	3.5	-0.1	1.9	-0.3	-0.4
Pavlov. Cond. lever contacts	0.7	1.1	2.6	-0.1	1.6	0.2	-1.3
Pavlov. Cond. magazine entry number	0.4	0.6	2.0	0.0	-1.4	0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	1.0	1.5	-0.2	-1.2	1.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	4.1	-0.2	2.0	-0.3	-0.2
Pavlov. Cond. response bias	0.5	0.7	2.2	-0.1	1.5	0.2	-0.8
Time in closed arm before self-admin	0.6	1.0	1.6	-1.2	1.3	0.8	0.3
Time in closed arm after self-admin	1.0	1.1	2.0	-1.2	1.1	1.4	0.2
Time in open arm before self-admin	3.9	4.8	6.8	2.6	-2.4	-2.6	-0.1
Time in open arm after self-admin	0.7	0.8	1.9	-1.0	1.4	0.2	-0.6
Bone: periosteal estimation	1.5	3.5	6.6	-2.6	2.2	0.7	-1.3
Bone: periosteal perimeter	1.0	2.0	3.6	-1.9	1.7	0.8	-0.9
Bone: post-yield work	0.7	1.2	3.3	0.5	-1.1	-0.1	-1.8
Progressive ratio test 1 active lever presses	0.7	1.3	1.8	1.4	-0.3	-1.2	-1.3
Progressive ratio test 1 breakpoint	0.6	1.0	1.7	1.2	-0.2	-1.0	-1.3
Progressive ratio test 1 inactive lever presses	2.4	6.4	11.6	3.4	-2.4	-2.9	0.0
Progressive ratio test 2 active lever presses	0.7	1.0	1.5	1.0	-0.0	-1.2	-1.2
Progressive ratio test 2 breakpoint	0.7	0.9	1.4	1.0	-0.1	-1.2	-1.2
Progressive ratio test 2 inactive lever presses	0.4	1.2	2.6	1.3	-0.0	-1.6	-0.6
Incentive Sensitization - Responses	0.1	0.3	0.7	-0.4	0.9	-0.5	0.0
Incentive Sensitization - Breakpoint	0.1	0.3	0.6	-0.4	0.8	-0.6	0.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	-1.2	0.9	0.2	-0.1
Progressive ratio	0.2	0.7	0.8	0.9	-0.6	-0.9	0.9
Food seeking constrained by brief footshock	0.8	1.1	2.6	-0.7	0.0	1.1	-1.6
Seeking ratio, punishment vs. effort	1.3	2.8	3.8	-1.9	0.7	1.9	-1.9
Retroperitoneal fat weight	0.8	3.5	7.6	1.5	-1.4	-1.5	2.8
Reaction time number correct	0.1	0.4	0.8	0.7	-0.7	0.1	-0.9
Reaction time mean minus median	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.2	0.5	0.1	0.5	0.4	-0.7
Reaction time num false alarms	1.4	2.4	4.0	1.7	-2.0	-1.5	0.6
Reaction time num false alarms AUC	1.2	2.7	4.7	1.8	-2.2	-1.6	0.5
Reaction time trials correct on left	0.1	0.4	0.8	0.7	-0.7	0.1	-0.9
Reaction time trials on left	0.1	0.4	0.7	0.7	-0.7	0.1	-0.9
Reaction time mean	0.9	2.0	3.2	-1.5	1.8	0.4	1.6
Reaction time mean AUC	0.6	1.5	2.5	-1.2	1.6	0.2	1.4
Median of all reaction times	2.1	3.2	5.1	-1.9	2.3	0.3	2.1
Reaction time omissions	0.1	0.1	0.3	-0.2	-0.1	0.4	0.5
Reaction time false alarm rate	1.1	1.5	2.0	1.1	-1.4	-1.4	0.9
Reaction time premature initiation rate	1.1	1.8	6.9	0.4	-0.1	0.0	-2.6
Reaction time premature initiations	0.7	2.2	7.8	0.8	-0.6	-0.0	-2.8
Std. dev. reaction times	0.2	0.7	1.4	-1.2	0.9	0.8	0.0
Reaction time trials completed	0.1	0.4	0.7	0.7	-0.7	0.1	-0.9
Reaction time trials AUC	0.1	0.3	0.5	0.6	-0.6	0.1	-0.7
Run reversals in cocaine runway, females	0.2	0.2	0.7	0.1	0.3	-0.4	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.9	0.0	0.9	0.2	0.1
Latency to leave start box in cocaine runway	2.4	3.3	6.3	2.5	-1.9	-1.7	0.2
Latency to leave start box in cocaine runway, F	1.4	1.7	2.6	1.6	-1.0	-1.5	1.0
Latency to leave start box in cocaine runway, M	3.3	3.1	4.8	2.1	-2.2	-0.7	-1.6
Std. dev. time between licks in bursts	0.6	1.2	1.6	1.3	-1.3	-1.2	0.1
Total sessions with >9 infusions	1.9	2.3	4.5	2.1	-1.1	-1.7	-0.8
Short access day 1 total inactive lever presses	0.1	0.2	0.5	0.4	-0.5	-0.7	0.2
Short access day 10 total inactive lever presses	0.1	0.5	0.6	0.6	-0.8	-0.7	0.8
Short access day 1 total infusions	0.4	0.9	2.1	1.5	-0.6	-0.9	-0.4
Short access day 10 total infusions	0.7	1.1	2.6	1.6	-0.8	-1.1	-0.3
Short access total infusions	1.0	1.4	3.3	1.8	-0.8	-1.3	-0.0
Short access day 1 locomotion	1.2	2.0	3.4	1.4	-0.6	-1.9	-1.6
Short access day 10 total locomotion	0.2	0.7	1.8	1.3	-0.3	-0.8	-0.4
Short access total locomotion	1.6	2.5	4.3	2.1	-1.4	-1.9	-0.3
One hour access (0.3 mA shock)	0.3	0.4	0.5	0.7	0.6	-0.5	-0.7
Compulsive drug intake	0.1	0.1	0.2	0.4	0.2	-0.4	0.0
One hour access (shock baseline)	0.1	0.2	0.4	0.7	-0.1	-0.3	-0.5
Social response proportion	0.8	1.0	2.5	-1.6	0.5	0.8	-0.7
Social responses	0.8	1.1	2.9	-1.7	1.0	0.3	-0.7
Social time	0.2	0.3	0.8	-0.9	0.6	0.2	-0.4
Soleus weight	0.6	1.7	4.0	0.2	-2.0	0.1	-1.6
Bone: stiffness	1.6	2.8	7.1	-2.7	1.3	1.3	-0.9
Tibialis anterior weight	0.0	0.1	0.3	0.2	-0.5	-0.5	-0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.2	0.3	-0.6	0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.2	-0.6	-0.4	0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.7	-0.0	0.1	-0.7	0.9
Time to tail flick, test, after self-admin	0.5	0.5	1.0	1.0	-0.6	0.6	-0.5
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.2	0.7	-1.1	0.1	-0.0
Delta time to tail flick, test, before/after SA	0.9	1.1	2.4	1.1	-0.6	0.7	-1.5
Tibia length	2.3	6.5	13.5	-3.7	2.7	1.9	-1.3
Ambulatory time before self-admin	0.4	1.2	2.5	-1.6	0.2	1.4	-0.5
Ambulatory time after self-admin	0.2	0.3	0.4	-0.4	-0.7	-0.6	-0.6
Bone: tissue strength	0.9	0.9	2.2	-0.3	-1.0	0.6	-1.5
Total heroin consumption	0.3	0.4	1.4	-0.3	-0.0	-0.0	-1.2
Bone: trabecular number	1.6	3.1	6.2	-1.8	-0.1	2.5	-1.7
Bone: trabecular spacing	1.1	1.6	4.2	0.6	0.7	-1.2	2.1
Bone: trabecular thickness	0.8	1.1	2.6	-0.7	-0.4	1.1	-1.6
Bone: trabecular tissue density	0.7	1.2	2.9	-0.1	1.7	-1.1	0.8
Water consumed over 24 hours	1.0	1.9	3.7	1.9	-1.6	-0.8	-0.9
Number of responses in last shaping day	0.6	0.8	1.7	0.7	-0.2	-1.0	-1.3