Hub : Genes

Fkrp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Fkrp 0.16 0.13 5.6e-17 0.08 0.11 0.1 0.11 4.2e-12 4.3e-16 4.7e-15 7.1e-16
2 Adipose mRNA stability Fkrp 0.03 0.03 5.1e-03 0.01 0.01 0.02 0.02 1.5e-02 1.7e-02 2.4e-03 6.1e-03
3 Liver mRNA stability Fkrp 0.03 0.03 7.7e-04 0.03 0.02 0.01 0.02 6.1e-04 9.9e-04 9.3e-03 1.3e-03
4 NAcc mRNA stability Fkrp 0.04 0.03 1.8e-06 0.03 0.03 0.03 0.03 1.8e-05 5.7e-06 1.2e-05 1.9e-05
5 NAcc intron excision ratio chr1_86610552_86613321 0.02 0.02 1.8e-03 0.01 0.01 0 0.01 1.3e-02 7.6e-03 6.3e-02 2.5e-02
6 Adipose gene expression Fkrp 0.07 0.06 2.1e-08 0.07 0.07 0.06 0.07 3.9e-08 5.6e-08 1.1e-07 3.1e-08
7 Eye gene expression Fkrp 0.23 0.2 8.6e-03 0.06 0.13 0.12 0.1 3.9e-02 5.0e-03 8.0e-03 1.1e-02
8 NAcc intron excision ratio chr1_86596881_86613321 0.02 0.02 1.8e-03 0.01 0.01 0 0.01 1.5e-02 5.3e-03 6.3e-02 2.7e-02
9 Brain mRNA stability Fkrp 0.04 0.04 9.4e-04 0.03 0.02 0.02 0.02 2.1e-03 2.2e-03 5.6e-03 4.1e-03
10 Brain isoform ratio NM_001025678.1 0.03 0.03 3.8e-03 0.02 0.02 0.04 0.03 5.3e-03 2.7e-03 2.6e-04 9.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.10.60.4-0.2-0.20.2-0.20.3-0.20.2-0.80.6
Area under the delay curve0.70.81.7-1.31.11.0-0.90.9-0.90.9-0.9-0.3-0.0
BMI with tail1.13.85.12.3-2.2-2.02.0-2.01.9-2.02.01.9-0.5
BMI without tail1.75.36.42.4-2.5-2.42.4-2.42.3-2.42.42.5-0.9
Body weight2.08.511.43.4-3.4-3.03.1-3.03.0-3.03.02.6-0.7
Weight adjusted by age0.10.20.70.2-0.4-0.30.4-0.40.3-0.40.40.8-0.4
Bone surface0.50.91.61.3-1.1-1.01.0-1.01.1-1.01.00.20.2
Bone volume0.30.50.80.9-0.8-0.70.7-0.70.8-0.70.7-0.20.4
Breakpoint value in progressive ratio session2.73.25.6-2.41.92.0-1.91.9-1.91.9-1.9-0.70.2
Number of licking bursts2.43.95.12.2-2.3-2.02.1-2.02.0-2.12.01.9-0.4
Context. condit. distance diff. score0.00.00.10.4-0.2-0.10.2-0.20.2-0.20.2-0.10.0
Locomotion velocity, session 10.40.41.0-0.50.70.5-0.50.5-0.70.5-0.5-1.00.6
Locomotion distance, session 10.00.00.2-0.10.10.2-0.10.1-0.10.1-0.1-0.40.2
Locomotion velocity, session 21.72.02.61.6-1.6-1.51.5-1.51.5-1.51.51.1-0.2
Locomotion distance, session 20.40.60.80.8-0.9-0.70.8-0.80.8-0.80.80.9-0.4
Locomotion velocity, session 30.30.30.60.8-0.5-0.50.6-0.60.6-0.60.60.3-0.0
Locomotion distance, session 30.80.91.5-1.21.21.0-1.00.9-0.90.9-0.9-0.70.1
Stereotopy head waving bouts, day 30.80.91.61.3-1.1-0.91.0-1.00.9-1.01.00.60.0
Stereotopy head waving duration, day 30.60.71.51.2-1.0-0.80.8-0.80.8-0.80.80.40.1
Locomotion velocity, session 70.70.81.5-0.50.90.9-0.90.9-0.80.9-0.9-1.20.7
Locomotion distance, session 70.10.10.30.6-0.1-0.00.1-0.10.3-0.10.1-0.30.2
Stereotopy head waving bouts, day 70.40.50.70.5-0.7-0.90.8-0.80.6-0.80.80.6-0.1
Stereotopy head waving duration, day 70.40.50.70.5-0.7-0.80.8-0.80.7-0.80.80.6-0.2
Locomotion velocity, session 80.00.00.20.00.20.2-0.20.2-0.10.2-0.2-0.40.3
Locomotion distance, session 80.00.00.00.2-0.2-0.00.1-0.10.2-0.10.10.1-0.1
Degree of sensitization distance0.80.82.21.5-1.1-0.80.9-0.90.9-0.90.90.40.1
Degree of sensitization stereotypy0.60.60.90.5-0.7-1.00.9-0.90.8-0.90.90.8-0.3
Conditioned locomotion0.20.20.6-0.80.40.4-0.40.4-0.30.4-0.40.5-0.5
Cocaine response after cond. corrected0.30.40.50.6-0.6-0.60.6-0.60.7-0.60.60.7-0.2
Cocaine response after cond. not corrected1.01.21.51.1-1.2-1.11.1-1.11.1-1.11.11.2-0.5
Cocaine response before conditioning2.02.33.51.9-1.8-1.61.6-1.61.5-1.61.61.4-0.5
Saline control response1.21.62.21.5-1.4-1.31.4-1.41.4-1.41.41.1-0.3
Bone: connectivity density0.00.10.10.3-0.3-0.30.2-0.20.3-0.20.2-0.30.3
Bone: cortical apparent density0.00.10.1-0.20.40.2-0.30.3-0.20.3-0.3-0.3-0.1
Bone: cortical area1.72.64.22.0-1.9-1.71.7-1.71.7-1.71.70.9-0.0
Bone: cortical porosity0.10.10.1-0.20.10.4-0.30.4-0.30.3-0.4-0.00.1
Bone: cortical porosity0.00.00.20.2-0.3-0.10.1-0.10.1-0.10.10.4-0.1
Bone: cortical thickness0.50.81.41.2-1.1-0.90.9-0.91.0-0.90.90.10.2
Bone: cortical thickness0.81.01.51.2-1.1-1.01.1-1.11.1-1.11.10.30.0
Bone: cortical tissue density0.10.10.2-0.30.50.3-0.40.4-0.30.4-0.4-0.4-0.0
Condit. Reinf. active minus inactive responses0.91.01.11.0-1.0-1.01.0-1.00.9-1.01.01.1-0.3
Condit. Reinf. active-inactive response ratio0.90.91.70.9-1.0-1.01.0-1.00.8-1.01.01.3-0.5
Condit. Reinf. active responses0.50.60.80.9-0.8-0.80.8-0.80.7-0.80.80.8-0.2
Condit. Reinf. inactive responses0.10.10.50.00.30.2-0.30.3-0.20.3-0.3-0.70.4
Incentive salience index mean0.70.91.11.1-1.0-1.01.0-1.00.9-1.01.00.9-0.2
Condit. Reinf. lever presses0.20.30.50.7-0.6-0.70.6-0.60.6-0.60.60.4-0.0
Condit. Reinf. active minus inactive responses0.00.00.10.3-0.1-0.20.1-0.10.1-0.10.1-0.20.2
Condit. Reinf. active-inactive response ratio0.10.10.10.4-0.2-0.30.2-0.20.3-0.20.2-0.30.3
Condit. Reinf. active responses0.10.10.1-0.20.30.3-0.30.3-0.30.3-0.3-0.40.1
Condit. Reinf. inactive responses0.30.40.6-0.70.70.7-0.70.7-0.80.7-0.7-0.50.0
Condit. Reinf. lever presses0.10.20.50.4-0.5-0.40.4-0.40.4-0.40.40.7-0.4
Condit. Reinf. lever reinforcers received0.10.10.1-0.30.40.3-0.30.3-0.30.3-0.3-0.40.1
Conditioned reinforcement - actives2.33.95.92.4-2.3-2.02.0-2.02.0-2.02.01.8-0.4
Conditioned reinforcement - inactives2.02.95.02.2-2.0-1.81.8-1.81.8-1.81.81.2-0.1
Conditioned locomotion1.51.93.31.8-1.7-1.31.5-1.41.5-1.41.41.0-0.0
Patch foraging indifference point 0 sec0.20.40.70.8-0.7-0.70.7-0.70.6-0.70.70.30.2
Patch foraging indifference point AUC4.05.89.03.0-2.6-2.52.5-2.52.6-2.52.52.0-0.6
Delay disc. indifference point, 0s delay0.40.40.5-0.70.60.7-0.60.6-0.50.6-0.6-0.70.6
Delay disc. indifference point, 16s delay0.20.30.5-0.60.70.6-0.50.5-0.60.5-0.50.10.0
Delay disc. indifference point, 2s delay1.51.62.7-1.61.61.4-1.31.3-1.31.3-1.3-0.70.0
Delay disc. indifference point, 24s delay0.10.10.6-0.20.1-0.10.1-0.1-0.1-0.10.10.8-0.5
Delay disc. indifference point, 4s delay0.10.10.20.1-0.3-0.30.4-0.50.5-0.40.40.3-0.2
Delay disc. indifference point, 8s delay1.31.53.2-1.81.51.3-1.31.3-1.21.3-1.2-0.50.2
Indifference point function ln k1.83.24.3-2.12.01.9-1.81.8-1.81.8-1.8-1.90.5
Indifference point function log k1.83.24.3-2.12.01.9-1.81.8-1.81.8-1.8-1.90.5
Patch foraging total patch changes 0 sec0.30.50.70.8-0.8-0.80.8-0.80.7-0.80.80.30.2
Patch foraging total patch changes 12 sec2.33.05.52.3-1.9-1.81.8-1.81.8-1.81.81.3-0.2
Patch foraging total patch changes 18 sec1.82.84.82.2-1.8-1.81.8-1.81.7-1.81.81.1-0.1
Patch foraging total patch changes 24 sec1.01.72.31.5-1.5-1.31.3-1.31.3-1.31.31.2-0.1
Patch foraging total patch changes 6 sec2.23.45.62.4-2.0-1.91.9-1.91.9-1.91.91.3-0.3
Patch foraging time to switch 0 sec1.63.24.3-2.11.91.9-1.91.9-1.91.9-1.9-1.30.4
Patch foraging water rate 0 sec1.83.95.12.3-2.2-2.12.1-2.12.1-2.12.11.3-0.3
Patch foraging water rate 12 sec0.00.10.10.2-0.4-0.20.3-0.30.3-0.20.2-0.10.3
Patch foraging water rate 18 sec0.00.00.10.0-0.2-0.10.2-0.20.2-0.20.2-0.20.2
Patch foraging water rate 24 sec0.00.00.2-0.2-0.1-0.10.1-0.10.1-0.10.1-0.40.5
Patch foraging water rate 6 sec0.71.01.90.8-1.1-1.01.0-1.01.0-1.01.01.4-0.5
Seeking ratio, delayed vs. immediate footshock2.22.73.7-1.91.91.6-1.61.6-1.71.6-1.6-1.80.7
Distance traveled before self-admin0.00.00.1-0.10.10.1-0.0-0.0-0.0-0.00.00.2-0.1
Distance traveled after self-admin0.80.91.7-1.31.11.1-1.01.0-0.91.0-1.0-0.4-0.1
Extensor digitorum longus weight2.08.010.63.2-3.3-3.13.0-3.03.1-3.03.02.0-0.6
Bone: elastic displacement0.81.01.9-0.81.00.9-1.01.0-1.01.0-1.0-1.40.8
Bone: elastic work0.20.20.50.7-0.4-0.40.4-0.30.3-0.30.3-0.40.7
Bone: endosteal estimation0.00.00.00.10.1-0.00.00.00.0-0.0-0.00.00.1
Bone: endosteal perimeter0.10.10.20.5-0.4-0.30.4-0.40.3-0.40.40.20.2
Epididymis fat weight0.10.41.5-0.40.60.5-0.50.5-0.60.6-0.5-1.20.7
Delta time in closed arm before/after self-admin0.60.61.5-0.80.80.7-0.70.7-0.70.7-0.7-1.20.4
Delta time in open arm before/after self-admin0.30.30.70.3-0.5-0.50.5-0.50.5-0.50.50.8-0.4
Diff in mean of infusions in LGA sessions2.12.64.4-2.11.91.7-1.71.7-1.71.7-1.6-0.90.3
Delay discount exponential model param0.50.61.31.1-1.0-0.80.7-0.70.7-0.70.70.10.1
Extinction: sum of active levers before priming0.00.00.1-0.20.00.1-0.10.1-0.20.1-0.1-0.0-0.0
Active lever presses in extinction session 60.50.52.10.1-0.5-0.50.6-0.60.5-0.70.71.4-0.9
Bone: final force0.60.91.31.0-1.2-1.01.0-1.01.0-1.01.00.8-0.2
Bone: final moment0.81.41.91.3-1.4-1.21.2-1.31.2-1.21.20.8-0.1
Food consumed during 24 hour testing period4.66.37.8-2.82.72.7-2.62.6-2.72.6-2.6-2.40.9
Glucose0.81.22.1-1.01.21.0-1.11.1-0.91.1-1.1-1.40.8
Heart weight1.21.92.91.7-1.6-1.41.4-1.41.4-1.41.41.3-0.2
Delay discount hyperbolic model param0.40.41.11.0-0.9-0.70.6-0.60.6-0.60.60.10.1
Intermittent access intake day 1-15 change0.10.20.40.7-0.4-0.60.5-0.50.3-0.50.50.10.3
Intermittent access intake escalation0.20.40.70.8-0.6-0.80.7-0.70.5-0.70.70.30.2
Intermittent access intake escalation 20.10.10.2-0.20.40.2-0.20.2-0.30.2-0.2-0.50.3
Intermitt. access day 1 inactive lever presses0.20.61.51.0-0.7-0.70.7-0.70.6-0.80.71.2-0.5
Intermitt. access day 15 inactive lever presses0.20.50.90.8-0.6-0.60.7-0.70.4-0.70.71.0-0.4
Intermitt. access escalation Index0.30.41.0-0.80.90.7-0.60.6-1.00.6-0.60.0-0.1
Intermittent access day 1 total infusions2.43.95.72.4-2.4-2.12.1-2.02.2-2.02.01.40.1
Intermittent access day 15 total infusions1.11.72.71.6-1.5-1.51.4-1.41.3-1.31.30.70.4
Intermittent access terminal intake (last 3 days)1.11.42.31.5-1.4-1.31.2-1.21.3-1.21.20.50.4
Intermittent access total infusions2.42.94.32.0-2.1-1.91.8-1.81.8-1.71.81.10.2
Intermittent access day 1 locomotion0.70.92.01.4-1.3-0.91.0-0.91.0-0.90.90.30.4
Intermittent access day 15 total locomotion0.20.40.70.8-0.8-0.60.6-0.60.6-0.50.6-0.20.8
Intermittent access total locomotion1.82.13.71.9-1.8-1.51.5-1.51.5-1.51.50.50.5
Intermittent access standard deviation0.20.30.5-0.70.60.5-0.60.6-0.60.6-0.6-0.60.5
Left kidney weight5.424.933.35.8-5.8-5.25.2-5.25.3-5.25.24.2-1.4
Right kidney weight4.721.327.95.3-5.3-4.94.9-4.94.9-4.94.93.8-1.2
Cocaine induced anxiety0.00.00.2-0.10.00.2-0.20.20.20.2-0.2-0.40.0
Post-drug Anxiety0.10.10.1-0.30.20.3-0.30.3-0.10.3-0.3-0.40.1
Baseline Anxiety0.80.91.4-1.01.10.9-0.91.0-1.20.9-0.9-0.80.5
Tail length1.03.95.12.2-2.3-2.12.0-2.02.1-2.02.02.0-0.8
Length with tail0.73.14.22.0-2.1-1.91.8-1.81.9-1.81.81.4-0.4
Length without tail0.41.32.21.5-1.4-1.21.2-1.21.2-1.21.20.60.1
Times rat made contact with spout0.30.40.8-0.50.70.6-0.60.6-0.60.6-0.6-0.90.5
Lifetime Intake2.83.45.02.2-2.2-2.01.9-1.92.0-1.91.91.40.2
Liver weight, left2.84.66.42.0-2.3-2.12.2-2.22.1-2.22.22.5-1.3
Liver weight, right1.93.44.11.8-2.0-1.91.9-1.91.9-1.91.92.0-0.6
Locomotor activity1.72.73.51.7-1.9-1.71.7-1.71.6-1.71.71.7-0.5
Locomotor testing distance1.32.33.11.5-1.8-1.51.6-1.61.4-1.61.61.6-0.4
Locomotor testing rearing4.69.311.73.4-3.4-3.13.2-3.23.0-3.23.23.1-0.9
Locomotion in novel chamber1.01.21.6-1.11.31.1-1.11.1-1.21.1-1.1-1.20.4
Locomotion in novel chamber post-restriction0.91.42.3-1.51.41.2-1.21.2-1.31.2-1.2-0.90.1
Fecal boli incidents, locomotor time 10.20.30.60.8-0.6-0.50.6-0.60.4-0.60.6-0.40.5
Change in fecal boli incidents, locomotor task0.70.71.1-0.71.10.7-0.90.9-0.90.9-0.9-0.50.3
Time >=10cm from walls, locomotor time 10.00.00.1-0.10.10.3-0.00.0-0.2-0.0-0.00.10.1
Bouts of movement, locomotor time 12.93.34.7-2.02.21.9-2.02.0-2.02.0-2.0-1.10.6
Total resting periods, locomotor time 13.53.95.4-2.12.32.1-2.12.1-2.12.1-2.1-1.50.7
Rest time, locomotor task time 10.20.30.7-0.10.50.6-0.50.4-0.50.4-0.5-0.80.7
Distance moved, locomotor task time 10.60.91.90.4-1.0-1.00.9-0.90.9-0.90.91.4-1.0
Vertical activity count, locomotor time 10.10.30.70.3-0.4-0.70.4-0.40.3-0.40.40.8-0.7
Time >=10cm from walls, locomotor time 20.00.00.10.3-0.1-0.10.1-0.10.1-0.10.1-0.30.1
Bouts of movement, locomotor time 24.26.811.1-3.32.82.7-2.82.8-2.82.8-2.8-1.40.8
Total resting periods, locomotor time 23.86.610.3-3.22.82.7-2.72.7-2.82.7-2.7-1.61.0
Rest time, locomotor task time 20.50.61.7-0.40.70.9-0.70.7-0.60.7-0.7-1.30.8
Distance moved, locomotor task time 21.11.32.31.0-1.2-1.41.1-1.11.2-1.11.11.5-0.9
Vertical activity count, locomotor time 20.20.30.90.4-0.3-0.80.3-0.30.3-0.30.30.9-0.8
Light reinforcement 10.10.31.00.4-0.6-0.40.5-0.50.3-0.60.51.0-0.4
Light reinforcement 20.71.12.21.1-1.2-1.01.0-1.01.0-1.01.01.5-0.7
Bone: marrow area0.00.00.00.10.0-0.10.1-0.10.1-0.10.10.1-0.0
Bone: maximum diameter2.54.66.12.4-2.5-2.22.2-2.22.2-2.22.22.2-0.7
Bone: maximum force0.30.50.80.8-0.9-0.80.8-0.80.8-0.80.80.40.0
Bone: maximum moment0.40.81.21.1-1.1-0.90.9-0.91.0-0.90.90.30.1
Mean time between licks in bursts0.00.00.1-0.1-0.00.0-0.00.0-0.00.0-0.00.4-0.2
Mean num. licks in bursts3.75.87.5-2.62.72.5-2.52.5-2.52.5-2.5-2.50.7
Cd content in liver0.40.41.0-0.40.60.7-0.60.6-0.70.6-0.6-1.00.4
Co content in liver1.01.11.7-1.31.21.1-1.11.1-1.21.1-1.1-0.90.3
Cu content in liver0.50.50.80.7-0.8-0.80.7-0.70.9-0.70.70.8-0.5
Fe content in liver3.23.95.02.2-2.2-2.12.1-2.02.0-2.02.01.8-0.6
K content in liver0.30.30.60.3-0.5-0.60.6-0.60.6-0.60.60.8-0.4
Mg content in liver0.90.92.20.6-1.0-0.80.9-0.90.9-0.90.91.5-0.9
Mn content in liver0.91.01.41.0-1.0-1.11.0-1.01.2-1.01.00.9-0.5
Na content in liver0.00.00.1-0.30.2-0.0-0.10.00.10.1-0.0-0.1-0.2
Rb content in liver0.00.00.1-0.1-0.1-0.00.2-0.20.2-0.20.20.4-0.4
Se content in liver5.26.211.12.1-2.5-2.52.5-2.52.4-2.52.53.3-1.7
Sr content in liver0.10.10.20.5-0.4-0.30.3-0.30.3-0.30.30.10.3
Zn content in liver2.02.33.91.2-1.6-1.51.6-1.51.5-1.61.62.0-0.9
Bone: minimum diameter0.30.60.90.9-0.8-0.80.8-0.80.9-0.80.80.10.2
Time in familiar zone, hab. session 10.20.20.60.8-0.6-0.30.4-0.30.3-0.30.3-0.30.5
Time in novel zone, hab. session 10.80.81.50.7-0.8-0.90.9-0.80.9-0.90.81.2-0.7
Total zone transitions, hab. session 10.00.00.10.3-0.2-0.10.2-0.20.1-0.20.2-0.20.2
Total locomotion distance, hab. session 10.40.50.7-0.70.70.8-0.70.7-0.70.7-0.7-0.80.4
Locomotion velocity, hab. session 11.11.51.9-1.21.41.4-1.31.3-1.31.3-1.3-1.30.5
Time in familiar zone, hab. session 20.40.51.11.1-0.8-0.70.7-0.70.6-0.70.7-0.10.5
Time in novel zone, hab. session 20.40.51.3-1.10.70.7-0.60.6-0.60.6-0.60.4-0.5
Total zone transitions, hab. session 20.30.40.60.8-0.8-0.70.7-0.70.6-0.70.70.4-0.0
Total locomotion distance, hab. session 20.50.60.9-0.90.90.8-0.80.8-0.90.8-0.8-0.90.4
Locomotion velocity, hab. session 20.30.30.5-0.60.60.7-0.60.6-0.60.6-0.6-0.70.3
Novel to familiar place preference ratio0.60.61.00.7-0.8-0.80.8-0.80.8-0.80.81.0-0.5
Novelty place preference0.50.50.80.7-0.7-0.70.7-0.70.7-0.70.70.9-0.4
Time in novel zone, NPP test0.50.60.80.7-0.8-0.70.8-0.80.8-0.80.80.9-0.4
Total zone transitions, NPP test0.10.10.30.4-0.5-0.30.4-0.40.3-0.40.40.20.0
Total locomotion distance, NPP test0.00.00.10.3-0.2-0.10.2-0.20.1-0.20.20.00.1
Locomotion velocity, NPP test0.00.00.10.3-0.3-0.10.2-0.20.1-0.20.20.00.2
Intraocular pressure0.10.10.7-0.10.30.3-0.30.3-0.30.3-0.3-0.80.3
Delta distance traveled before/after self-admin0.80.91.6-1.31.11.0-1.01.0-0.91.0-1.0-0.5-0.0
Delta ambulatory time before/after self-admin0.20.20.3-0.60.50.4-0.50.5-0.40.5-0.5-0.5-0.1
Parametrial fat weight0.00.10.20.4-0.0-0.30.2-0.20.3-0.20.2-0.40.0
Pavlov. Cond. lever latency0.50.71.0-0.60.80.9-0.90.9-0.70.9-0.9-1.00.4
Pavlov. Cond. magazine entry latency0.30.40.90.3-0.6-0.60.6-0.60.5-0.60.61.0-0.6
Pavlov. Cond. change in total contacts0.40.41.0-1.00.70.6-0.60.6-0.80.6-0.6-0.1-0.1
Pavlov. Cond. index score0.40.51.30.4-0.7-0.70.7-0.70.6-0.70.71.1-0.6
Pavlov. Cond. latency score0.20.20.60.1-0.4-0.40.4-0.40.2-0.40.40.8-0.4
Pavlov. Cond. lever contacts0.40.40.80.5-0.7-0.70.7-0.70.5-0.70.70.9-0.3
Pavlov. Cond. magazine entry number0.20.20.6-0.10.40.4-0.40.4-0.30.4-0.4-0.80.6
Pavlov. Cond. intertrial magazine entries0.00.00.10.2-0.1-0.00.0-0.00.1-0.00.0-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.50.61.30.5-0.8-0.80.8-0.80.6-0.80.81.1-0.6
Pavlov. Cond. response bias1.21.52.31.1-1.3-1.31.3-1.31.1-1.31.31.5-0.7
Pavlov. Cond. lever latency0.10.10.2-0.50.40.4-0.40.4-0.30.4-0.4-0.30.2
Pavlov. Cond. magazine entry latency0.00.00.10.0-0.1-0.00.0-0.0-0.0-0.00.00.3-0.1
Pavlov. Cond. change in total contacts0.30.40.6-0.70.70.6-0.60.6-0.60.6-0.6-0.80.3
Pavlov. Cond. index score0.00.00.0-0.10.00.1-0.00.0-0.10.0-0.00.2-0.1
Pavlov. Cond. latency score0.00.00.0-0.20.10.2-0.20.2-0.20.2-0.2-0.0-0.0
Pavlov. Cond. lever contacts0.30.30.50.7-0.7-0.60.6-0.60.6-0.60.60.6-0.2
Pavlov. Cond. magazine entry number0.20.30.40.5-0.5-0.60.6-0.60.6-0.60.60.3-0.2
Pavlov. Cond. intertrial magazine entries0.00.00.10.2-0.0-0.10.1-0.10.1-0.10.1-0.30.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.1-0.2-0.10.1-0.10.0-0.10.10.3-0.1
Pavlov. Cond. response bias0.00.00.10.2-0.2-0.10.2-0.20.1-0.20.20.3-0.1
Time in closed arm before self-admin0.50.71.41.2-1.0-0.90.9-0.90.8-0.90.90.40.0
Time in closed arm after self-admin1.51.72.0-1.41.41.3-1.31.3-1.31.3-1.3-1.40.5
Time in open arm before self-admin0.40.40.7-0.90.70.7-0.60.6-0.70.6-0.6-0.40.3
Time in open arm after self-admin0.00.00.2-0.0-0.2-0.10.1-0.10.2-0.10.10.4-0.2
Bone: periosteal estimation0.40.81.21.1-1.0-0.90.9-0.91.0-0.90.90.6-0.1
Bone: periosteal perimeter0.61.11.91.4-1.2-1.01.1-1.11.0-1.11.10.50.1
Bone: post-yield work0.20.30.4-0.60.60.7-0.70.6-0.50.7-0.6-0.50.2
Progressive ratio test 1 active lever presses3.64.57.12.7-2.5-2.42.2-2.22.3-2.12.21.40.3
Progressive ratio test 1 breakpoint3.34.16.42.5-2.4-2.32.1-2.12.2-2.02.11.30.4
Progressive ratio test 1 inactive lever presses2.43.55.02.2-2.2-2.11.9-1.91.9-1.91.91.6-0.0
Progressive ratio test 2 active lever presses3.94.56.82.6-2.5-2.32.2-2.22.1-2.22.21.70.1
Progressive ratio test 2 breakpoint4.24.87.32.7-2.6-2.32.3-2.32.1-2.32.31.80.0
Progressive ratio test 2 inactive lever presses1.52.44.22.0-1.7-1.71.7-1.71.5-1.61.61.1-0.1
Incentive Sensitization - Responses2.02.84.42.1-2.0-1.71.8-1.81.5-1.81.81.3-0.1
Incentive Sensitization - Breakpoint2.02.64.32.1-1.9-1.71.7-1.71.5-1.71.71.3-0.1
Sum of active levers in priming session hrs 5-60.90.91.7-1.31.11.1-1.01.0-1.00.9-0.9-0.4-0.2
Progressive ratio1.11.73.4-1.91.51.4-1.41.3-1.41.3-1.3-0.50.2
Food seeking constrained by brief footshock3.34.05.4-2.32.32.1-2.01.9-2.22.0-1.9-2.10.8
Seeking ratio, punishment vs. effort0.10.20.9-0.10.40.3-0.30.3-0.30.3-0.3-1.00.4
Retroperitoneal fat weight0.00.10.20.3-0.2-0.50.2-0.20.3-0.20.2-0.50.2
Reaction time number correct2.03.85.12.0-2.3-2.02.0-2.02.1-2.02.01.7-0.9
Reaction time mean minus median0.51.31.8-1.11.31.1-1.21.2-1.21.2-1.2-1.20.3
Reaction time mean minus median AUC0.10.20.4-0.30.50.4-0.50.5-0.40.5-0.5-0.60.1
Reaction time num false alarms5.07.09.32.8-3.0-2.82.8-2.82.8-2.82.82.5-0.7
Reaction time num false alarms AUC4.16.48.32.7-2.9-2.72.7-2.62.7-2.62.62.3-0.6
Reaction time trials correct on left2.03.85.12.0-2.3-2.02.0-2.02.1-2.02.01.7-0.9
Reaction time trials on left2.03.85.32.0-2.3-2.02.0-2.02.1-2.02.01.8-0.9
Reaction time mean1.62.53.4-1.71.91.6-1.71.7-1.61.7-1.7-1.30.3
Reaction time mean AUC1.22.02.7-1.61.61.4-1.51.5-1.41.5-1.5-1.20.2
Median of all reaction times1.42.02.8-1.71.71.4-1.51.5-1.51.5-1.5-1.00.2
Reaction time omissions0.10.10.40.1-0.4-0.30.2-0.20.3-0.20.30.6-0.3
Reaction time false alarm rate0.60.91.21.0-1.1-1.01.0-1.01.0-1.01.00.90.0
Reaction time premature initiation rate0.30.40.9-0.50.70.5-0.60.6-0.60.6-0.6-0.90.7
Reaction time premature initiations0.10.10.10.3-0.3-0.40.3-0.30.3-0.30.3-0.20.2
Std. dev. reaction times0.71.31.8-1.21.31.1-1.21.2-1.11.2-1.2-1.10.3
Reaction time trials completed2.03.85.32.0-2.3-2.02.0-2.02.1-2.02.01.8-0.9
Reaction time trials AUC2.65.06.82.4-2.6-2.32.3-2.32.4-2.32.32.0-1.0
Run reversals in cocaine runway, females0.50.50.7-0.60.50.7-0.80.8-0.60.8-0.8-0.60.2
Run reversals in cocaine runway, males0.30.30.50.7-0.5-0.50.6-0.60.5-0.60.60.3-0.2
Latency to leave start box in cocaine runway0.20.20.8-0.10.30.3-0.40.4-0.20.4-0.4-0.80.9
Latency to leave start box in cocaine runway, F0.10.20.50.6-0.4-0.30.2-0.20.4-0.20.2-0.40.7
Latency to leave start box in cocaine runway, M0.20.20.2-0.40.40.4-0.40.4-0.40.4-0.4-0.30.2
Std. dev. time between licks in bursts0.20.30.80.2-0.4-0.50.5-0.40.5-0.50.50.9-0.6
Total sessions with >9 infusions3.34.05.72.3-2.4-2.22.1-2.12.2-2.12.11.60.1
Short access day 1 total inactive lever presses2.63.45.02.2-2.1-1.91.9-1.91.8-1.91.91.5-0.2
Short access day 10 total inactive lever presses0.41.01.4-1.11.01.2-1.11.1-1.01.0-1.1-0.90.3
Short access day 1 total infusions2.12.84.12.0-2.0-1.81.7-1.71.8-1.71.71.20.1
Short access day 10 total infusions4.25.36.82.6-2.6-2.42.4-2.42.4-2.42.42.2-0.4
Short access total infusions2.83.64.92.1-2.2-2.12.0-1.92.0-1.91.91.7-0.1
Short access day 1 locomotion4.04.97.12.4-2.7-2.42.3-2.32.5-2.32.31.8-0.2
Short access day 10 total locomotion0.10.10.50.10.10.3-0.20.2-0.30.2-0.2-0.60.7
Short access total locomotion0.81.01.61.3-1.2-1.01.0-1.01.0-1.01.00.50.3
One hour access (0.3 mA shock)0.20.20.40.6-0.6-0.50.4-0.40.5-0.40.40.20.5
Compulsive drug intake0.10.10.20.4-0.2-0.20.2-0.20.1-0.20.20.4-0.4
One hour access (shock baseline)1.01.52.51.3-1.6-1.31.2-1.21.5-1.21.20.80.4
Social response proportion0.60.61.50.6-0.7-0.60.7-0.70.8-0.70.71.2-0.8
Social responses0.81.02.80.5-0.9-0.91.0-1.00.8-1.01.01.7-1.1
Social time2.53.46.3-2.52.21.9-1.91.9-2.01.9-1.9-1.0-0.1
Soleus weight0.20.61.00.7-1.0-0.80.8-0.80.7-0.80.80.9-0.4
Bone: stiffness0.81.41.81.2-1.3-1.21.2-1.21.3-1.21.21.1-0.4
Tibialis anterior weight3.913.117.24.0-4.1-3.83.8-3.83.9-3.83.83.0-1.0
Time to tail flick, vehicle, before self-admin1.61.72.51.6-1.4-1.51.3-1.31.6-1.31.30.7-0.4
Time to tail flick, vehicle, after self-admin0.30.40.5-0.70.70.7-0.60.6-0.70.6-0.6-0.60.5
Time to tail flick, test, before self-admin0.70.82.4-0.70.80.7-0.80.8-0.50.9-0.8-1.50.7
Time to tail flick, test, after self-admin0.10.10.50.5-0.3-0.0-0.00.00.10.0-0.0-0.70.7
Delta time to tail flick, vehicle, before/after SA0.40.40.6-0.60.70.7-0.60.6-0.70.6-0.6-0.70.4
Delta time to tail flick, test, before/after SA1.11.22.31.5-1.3-1.01.1-1.10.9-1.11.10.8-0.1
Tibia length0.51.33.01.2-1.4-1.01.1-1.11.0-1.11.11.7-0.6
Ambulatory time before self-admin0.10.10.2-0.40.40.4-0.20.2-0.30.2-0.20.1-0.1
Ambulatory time after self-admin1.21.42.3-1.51.31.3-1.31.2-1.21.2-1.2-0.6-0.1
Bone: tissue strength0.40.40.6-0.80.60.7-0.60.6-0.70.6-0.6-0.60.3
Total heroin consumption0.10.10.5-0.1-0.1-0.10.2-0.20.1-0.20.20.7-0.5
Bone: trabecular number0.00.10.40.2-0.1-0.10.0-0.00.10.00.0-0.60.6
Bone: trabecular spacing0.00.00.2-0.30.10.0-0.0-0.0-0.1-0.00.00.4-0.5
Bone: trabecular thickness1.21.52.91.7-1.4-1.31.3-1.31.3-1.31.30.40.3
Bone: trabecular tissue density0.10.20.50.5-0.4-0.30.3-0.30.3-0.40.30.7-0.4
Water consumed over 24 hours0.60.71.4-0.80.90.9-0.80.8-0.90.9-0.8-1.20.6
Number of responses in last shaping day1.82.02.81.7-1.7-1.31.4-1.41.4-1.41.41.6-0.3