Hub : Genes

Fkbp11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_001013105.2 0.03 0.02 2.2e-04 0.03 0.03 0.03 0.03 1.3e-04 2.2e-04 6.0e-04 2.3e-04
2 Adipose alternative TSS XM_006257344.4 0.03 0.02 4.2e-04 0.03 0.03 0.02 0.03 2.6e-04 4.1e-04 1.2e-03 4.6e-04
3 PL mRNA stability Fkbp11 0.02 0.02 1.4e-03 0.02 0.02 0.02 0.02 2.5e-03 1.2e-03 3.3e-03 2.4e-03
4 BLA alternative TSS NM_001013105.2 0.05 0.04 8.2e-03 0.04 0.04 0.04 0.04 2.1e-03 4.1e-03 5.9e-03 3.1e-03
5 Liver intron excision ratio chr7_129874872_129875083 0.22 0.11 0.0e+00 0.25 0.26 0.26 0.26 1.9e-27 7.3e-29 1.3e-28 1.1e-28
6 Adipose mRNA stability Fkbp11 0.02 0.02 6.1e-03 0.01 0.02 0.01 0.01 9.5e-03 4.6e-03 8.6e-03 7.9e-03
7 Liver mRNA stability Fkbp11 0.07 0.05 2.9e-08 0.06 0.06 0.06 0.06 1.3e-07 2.7e-07 2.4e-07 1.7e-07
8 Brain gene expression Fkbp11 0.06 0.04 6.1e-07 0.07 0.06 0.05 0.07 1.9e-07 2.1e-06 1.6e-05 5.7e-07
9 Liver gene expression Fkbp11 0.11 0.07 6.1e-06 0.04 0.03 0.03 0.03 1.4e-05 3.3e-04 6.8e-04 1.9e-04
10 PL gene expression Fkbp11 0.07 0.09 1.3e-04 0.04 0.03 0.03 0.03 6.4e-05 1.7e-04 1.4e-04 1.1e-04
11 RMTg alternative TSS NM_001013105.2 0.13 0.13 6.6e-03 0.06 0.06 0.05 0.06 8.3e-03 1.1e-02 1.4e-02 1.3e-02
12 pVTA gene expression Fkbp11 0.14 0.12 7.8e-03 0.04 0.03 0.03 0.03 1.1e-02 1.3e-02 1.5e-02 2.3e-02
13 BLA gene expression Fkbp11 0.06 0.05 1.0e-03 0.08 0.06 0.09 0.08 4.0e-05 3.9e-04 2.8e-05 6.0e-05
14 NAcc mRNA stability Fkbp11 0.09 0.07 1.8e-03 0.01 0 0.03 0.02 6.8e-03 6.8e-02 1.7e-04 2.0e-03
15 Liver intron excision ratio chr7_129874399_129874807 0.07 0.05 1.8e-09 0.08 0.07 0.07 0.08 4.4e-09 9.8e-09 1.2e-08 4.2e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density7.612.718.8-4.34.3-4.24.2-4.24.04.1-4.1-3.1-3.1-3.1-3.1-3.50.30.0
Area under the delay curve0.70.81.5-0.80.8-1.11.0-1.11.01.2-1.1-0.8-0.8-0.9-0.8-0.80.20.0
BMI with tail3.410.916.4-3.63.6-3.93.6-3.93.74.1-3.9-3.3-3.3-3.3-3.0-2.70.40.0
BMI without tail0.10.10.60.3-0.3-0.0-0.3-0.10.10.6-0.3-0.4-0.5-0.5-0.10.1-0.80.0
Body weight5.221.931.2-4.94.9-5.24.9-5.35.25.6-5.3-4.9-5.0-5.0-4.7-4.21.50.0
Weight adjusted by age2.52.84.5-1.41.4-1.61.5-1.61.81.8-1.7-1.9-2.0-2.1-1.9-1.71.70.0
Bone surface9.216.222.7-4.84.8-4.74.8-4.64.54.5-4.5-3.7-3.7-3.7-3.7-4.00.40.0
Bone volume6.911.616.8-4.14.1-4.04.1-3.93.83.8-3.8-3.1-3.1-3.1-3.1-3.50.00.0
Breakpoint value in progressive ratio session0.20.20.6-0.50.5-0.50.5-0.50.50.4-0.5-0.3-0.3-0.4-0.6-0.20.70.0
Number of licking bursts0.20.30.70.8-0.80.6-0.80.5-0.3-0.30.4-0.3-0.3-0.3-0.3-0.00.80.0
Context. condit. distance diff. score0.30.41.3-0.50.5-0.50.4-0.60.60.6-0.6-0.7-0.7-0.7-0.8-0.31.20.0
Locomotion velocity, session 10.80.81.31.1-1.11.1-1.01.1-1.0-1.11.20.70.70.70.80.80.40.0
Locomotion distance, session 12.93.75.41.9-1.91.9-1.82.0-2.1-2.02.02.32.32.32.32.0-0.60.0
Locomotion velocity, session 20.30.30.60.4-0.40.5-0.40.6-0.6-0.70.70.80.80.80.70.2-0.70.0
Locomotion distance, session 22.33.24.71.7-1.71.8-1.61.9-2.0-1.92.02.22.22.22.21.5-0.60.0
Locomotion velocity, session 33.44.04.92.1-2.12.2-2.02.2-2.2-2.12.12.22.22.22.21.8-1.50.0
Locomotion distance, session 34.34.76.02.2-2.22.4-2.12.4-2.5-2.32.32.42.42.42.41.7-1.50.0
Stereotopy head waving bouts, day 31.31.52.5-1.31.3-1.21.3-1.21.31.1-1.1-1.3-1.3-1.3-1.4-1.60.60.0
Stereotopy head waving duration, day 30.50.60.8-0.90.9-0.80.9-0.80.80.6-0.6-0.8-0.8-0.8-0.8-0.90.50.0
Locomotion velocity, session 70.10.10.20.4-0.40.5-0.40.4-0.4-0.20.20.10.10.10.2-0.10.10.0
Locomotion distance, session 71.01.22.11.4-1.41.4-1.41.4-1.3-1.11.20.90.90.91.10.7-0.10.0
Stereotopy head waving bouts, day 71.11.32.2-1.11.1-1.01.2-1.11.20.9-1.0-1.4-1.4-1.4-1.5-1.50.20.0
Stereotopy head waving duration, day 71.31.52.6-1.21.2-1.21.3-1.31.41.1-1.1-1.5-1.5-1.5-1.6-1.30.30.0
Locomotion velocity, session 80.00.00.20.0-0.0-0.1-0.0-0.10.10.1-0.1-0.1-0.1-0.1-0.10.10.40.0
Locomotion distance, session 81.21.82.61.3-1.31.3-1.31.4-1.4-1.41.41.61.61.61.61.40.20.0
Degree of sensitization distance0.70.71.2-0.70.7-0.70.6-0.80.80.9-0.8-1.0-1.0-1.0-0.9-0.71.10.0
Degree of sensitization stereotypy0.40.41.0-0.30.3-0.40.5-0.50.60.4-0.4-0.9-0.9-0.9-1.0-0.80.10.0
Conditioned locomotion0.30.42.4-0.20.2-0.20.3-0.20.40.1-0.1-0.7-0.7-0.7-0.8-0.71.50.0
Cocaine response after cond. corrected0.30.42.80.0-0.00.0-0.20.1-0.30.1-0.00.70.70.70.90.5-1.70.0
Cocaine response after cond. not corrected1.11.22.60.7-0.70.8-0.90.8-1.0-0.90.81.41.41.41.51.2-1.60.0
Cocaine response before conditioning3.03.66.32.0-2.02.2-1.92.2-2.1-2.52.41.91.91.91.81.70.00.0
Saline control response0.10.10.4-0.50.5-0.30.5-0.30.3-0.0-0.00.00.00.0-0.2-0.20.60.0
Bone: connectivity density5.28.212.8-3.63.6-3.53.5-3.43.23.3-3.3-2.4-2.4-2.4-2.4-2.8-0.20.0
Bone: cortical apparent density0.20.30.80.5-0.50.6-0.70.7-0.6-0.70.70.40.40.40.40.20.90.0
Bone: cortical area8.312.516.3-3.83.8-3.93.9-4.03.94.0-4.0-3.6-3.6-3.6-3.6-3.5-0.10.0
Bone: cortical porosity0.70.81.70.8-0.81.0-0.61.1-1.0-1.31.30.90.90.90.90.80.30.0
Bone: cortical porosity1.01.12.31.0-1.01.2-0.81.3-1.2-1.51.51.01.01.01.00.90.00.0
Bone: cortical thickness3.25.37.9-2.32.3-2.52.4-2.62.52.8-2.8-2.3-2.3-2.3-2.3-2.3-1.00.0
Bone: cortical thickness0.10.20.4-0.30.3-0.40.3-0.50.40.6-0.6-0.4-0.4-0.4-0.4-0.3-0.40.0
Bone: cortical tissue density0.30.41.00.6-0.60.8-0.80.8-0.7-0.80.80.50.50.50.50.31.00.0
Condit. Reinf. active minus inactive responses0.20.21.00.2-0.20.2-0.20.2-0.4-0.20.20.60.60.60.60.2-1.00.0
Condit. Reinf. active-inactive response ratio0.10.10.3-0.60.6-0.50.5-0.40.30.4-0.40.10.10.10.0-0.3-0.40.0
Condit. Reinf. active responses0.60.71.10.8-0.80.8-0.90.8-0.9-0.80.81.01.01.01.00.7-0.70.0
Condit. Reinf. inactive responses2.12.53.51.9-1.91.8-1.91.8-1.7-1.81.81.51.51.51.51.50.00.0
Incentive salience index mean0.00.00.2-0.10.1-0.20.1-0.20.20.3-0.3-0.0-0.0-0.0-0.0-0.3-0.40.0
Condit. Reinf. lever presses0.20.30.6-0.30.3-0.50.4-0.60.50.8-0.7-0.6-0.6-0.6-0.5-0.60.20.0
Condit. Reinf. active minus inactive responses0.00.00.10.1-0.10.2-0.10.2-0.1-0.20.20.00.00.00.10.0-0.10.0
Condit. Reinf. active-inactive response ratio0.30.30.40.6-0.60.6-0.60.6-0.6-0.60.60.60.60.60.60.6-0.60.0
Condit. Reinf. active responses0.10.20.40.4-0.40.5-0.40.6-0.5-0.60.60.30.30.30.40.3-0.10.0
Condit. Reinf. inactive responses0.40.51.00.8-0.80.9-0.80.9-0.8-1.01.00.60.60.60.60.60.40.0
Condit. Reinf. lever presses0.00.00.1-0.10.10.0-0.00.1-0.1-0.20.10.20.20.20.2-0.00.30.0
Condit. Reinf. lever reinforcers received0.40.60.90.8-0.80.9-0.80.9-0.9-0.90.90.70.70.70.80.7-0.30.0
Conditioned reinforcement - actives1.31.32.11.5-1.51.3-1.11.2-1.2-1.21.11.11.11.11.01.1-0.40.0
Conditioned reinforcement - inactives1.71.93.01.7-1.71.5-1.51.4-1.5-1.21.21.31.21.31.41.4-1.40.0
Conditioned locomotion0.20.30.80.9-0.90.7-0.50.6-0.5-0.60.60.30.20.20.30.60.30.0
Patch foraging indifference point 0 sec1.82.93.71.9-1.91.9-1.91.9-1.9-1.81.91.71.61.61.81.8-1.00.0
Patch foraging indifference point AUC0.20.21.10.5-0.50.5-0.30.5-0.4-0.50.60.30.20.30.4-0.0-1.10.0
Delay disc. indifference point, 0s delay1.21.32.1-1.01.0-1.21.3-1.21.21.3-1.2-1.4-1.4-1.4-1.2-1.2-0.20.0
Delay disc. indifference point, 16s delay0.91.01.4-0.80.8-1.01.0-1.11.11.2-1.1-1.2-1.2-1.2-1.1-0.90.30.0
Delay disc. indifference point, 2s delay1.11.31.6-1.31.3-1.21.2-1.21.21.0-1.2-1.0-1.0-1.1-1.1-1.11.30.0
Delay disc. indifference point, 24s delay1.21.21.5-1.11.1-1.21.2-1.21.21.2-1.2-1.2-1.2-1.2-1.1-1.00.60.0
Delay disc. indifference point, 4s delay0.10.10.3-0.40.4-0.50.4-0.50.30.6-0.5-0.1-0.1-0.1-0.0-0.30.30.0
Delay disc. indifference point, 8s delay2.12.23.5-1.51.5-1.71.8-1.71.61.9-1.8-1.4-1.4-1.5-1.3-1.20.10.0
Indifference point function ln k3.14.35.5-2.32.3-2.32.3-2.32.32.2-2.1-2.1-2.1-2.1-1.9-1.91.30.0
Indifference point function log k3.14.35.5-2.32.3-2.32.3-2.32.32.2-2.1-2.1-2.1-2.1-1.9-1.91.30.0
Patch foraging total patch changes 0 sec1.72.73.61.9-1.91.9-1.91.8-1.8-1.81.81.51.51.51.71.7-0.90.0
Patch foraging total patch changes 12 sec1.41.93.21.8-1.81.6-1.61.5-1.5-1.61.51.21.21.21.01.0-0.80.0
Patch foraging total patch changes 18 sec3.03.96.42.3-2.32.4-2.22.4-2.2-2.22.51.61.61.62.01.6-1.10.0
Patch foraging total patch changes 24 sec1.21.42.61.6-1.61.6-1.61.5-1.4-1.31.40.80.70.60.90.8-0.50.0
Patch foraging total patch changes 6 sec2.13.14.12.0-2.01.9-1.81.9-1.9-2.01.91.81.81.81.71.4-1.80.0
Patch foraging time to switch 0 sec2.03.14.71.8-1.81.9-2.01.9-1.9-2.21.91.91.91.91.51.50.90.0
Patch foraging water rate 0 sec2.84.56.3-2.12.1-2.22.2-2.32.32.5-2.3-2.5-2.5-2.5-2.1-2.0-0.70.0
Patch foraging water rate 12 sec3.35.06.5-2.52.5-2.42.5-2.42.42.5-2.2-2.5-2.5-2.4-2.1-2.10.80.0
Patch foraging water rate 18 sec0.30.40.8-0.50.5-0.60.6-0.70.70.8-0.9-0.8-0.8-0.8-0.8-0.30.60.0
Patch foraging water rate 24 sec3.04.15.7-2.22.2-2.12.0-2.12.21.9-1.9-2.3-2.3-2.2-2.4-1.91.60.0
Patch foraging water rate 6 sec3.45.06.4-2.42.4-2.42.4-2.42.42.5-2.4-2.5-2.5-2.5-2.3-2.10.70.0
Seeking ratio, delayed vs. immediate footshock0.20.31.1-0.60.6-0.60.6-0.60.40.7-0.7-0.00.00.00.1-0.2-1.00.0
Distance traveled before self-admin0.70.81.31.1-1.11.1-1.11.1-1.0-1.11.10.60.60.60.60.70.70.0
Distance traveled after self-admin0.20.20.40.4-0.40.4-0.40.4-0.5-0.40.60.50.60.60.60.30.10.0
Extensor digitorum longus weight3.814.820.1-3.63.6-4.13.7-4.34.34.5-4.5-4.3-4.3-4.3-4.4-3.41.60.0
Bone: elastic displacement3.84.35.72.2-2.22.3-2.42.4-2.3-2.42.42.12.12.12.12.20.10.0
Bone: elastic work0.10.11.7-0.20.20.00.00.1-0.1-0.20.20.10.10.10.10.21.30.0
Bone: endosteal estimation6.414.017.8-4.24.2-4.14.2-4.14.13.8-3.8-3.8-3.8-3.8-3.8-3.72.40.0
Bone: endosteal perimeter5.812.014.9-3.73.7-3.83.8-3.83.93.8-3.8-3.6-3.6-3.6-3.6-3.41.20.0
Epididymis fat weight0.10.30.8-0.60.6-0.60.5-0.60.50.9-0.6-0.4-0.5-0.6-0.2-0.3-0.50.0
Delta time in closed arm before/after self-admin0.30.32.4-0.50.5-0.50.6-0.50.30.3-0.50.40.30.30.1-0.1-1.60.0
Delta time in open arm before/after self-admin3.23.14.62.2-2.22.1-2.12.0-1.9-2.02.01.51.61.61.61.60.20.0
Diff in mean of infusions in LGA sessions1.11.22.2-1.41.4-1.31.2-1.31.21.1-1.5-0.8-0.8-0.8-1.2-0.90.20.0
Delay discount exponential model param0.60.71.20.8-0.81.0-0.91.0-0.9-1.11.10.70.70.80.70.7-0.40.0
Extinction: sum of active levers before priming0.40.40.7-0.70.7-0.60.7-0.60.70.5-0.5-0.7-0.7-0.7-0.8-0.50.70.0
Active lever presses in extinction session 60.30.30.5-0.70.7-0.70.7-0.70.60.5-0.6-0.2-0.2-0.2-0.5-0.50.40.0
Bone: final force7.912.817.2-4.14.1-4.14.1-4.14.04.1-4.1-3.4-3.4-3.4-3.4-3.41.00.0
Bone: final moment8.113.118.1-4.34.3-4.24.2-4.24.04.1-4.1-3.3-3.3-3.3-3.3-3.41.10.0
Food consumed during 24 hour testing period1.11.32.6-1.51.5-1.51.6-1.41.31.2-1.2-0.6-0.6-0.6-0.8-1.2-0.90.0
Glucose0.20.20.6-0.10.1-0.30.1-0.40.50.7-0.6-0.8-0.7-0.7-0.7-0.3-0.20.0
Heart weight0.00.00.1-0.20.2-0.20.2-0.20.10.0-0.20.30.30.30.10.2-0.20.0
Delay discount hyperbolic model param0.60.61.10.8-0.81.0-0.91.0-0.9-1.01.00.70.70.80.70.7-0.50.0
Intermittent access intake day 1-15 change1.21.21.61.3-1.31.2-1.21.1-1.2-1.00.91.21.21.21.10.9-1.10.0
Intermittent access intake escalation0.90.91.31.1-1.11.0-1.00.9-1.0-0.80.71.11.11.11.00.8-1.10.0
Intermittent access intake escalation 21.41.31.81.4-1.41.2-1.31.2-1.3-1.00.91.21.31.31.11.0-1.30.0
Intermitt. access day 1 inactive lever presses2.32.54.11.6-1.61.8-1.81.9-1.7-2.02.01.31.31.31.31.51.50.0
Intermitt. access day 15 inactive lever presses0.91.01.71.2-1.21.2-1.31.2-1.1-1.01.30.90.70.70.90.90.50.0
Intermitt. access escalation Index0.20.20.80.3-0.30.5-0.60.5-0.4-0.50.50.30.30.30.30.40.90.0
Intermittent access day 1 total infusions1.11.31.71.3-1.31.2-1.21.2-1.2-1.11.11.21.21.21.21.2-0.90.0
Intermittent access day 15 total infusions2.12.43.61.9-1.91.7-1.81.7-1.7-1.51.41.61.51.51.51.4-1.10.0
Intermittent access terminal intake (last 3 days)2.42.63.71.9-1.91.8-1.81.7-1.8-1.51.51.61.51.51.71.4-1.50.0
Intermittent access total infusions2.12.43.51.9-1.91.7-1.71.7-1.7-1.51.51.61.51.51.61.4-1.10.0
Intermittent access day 1 locomotion0.60.61.01.0-1.01.0-1.01.0-0.8-0.81.00.50.30.30.60.90.60.0
Intermittent access day 15 total locomotion0.91.02.51.6-1.61.3-1.21.2-1.1-0.91.00.40.30.30.71.00.10.0
Intermittent access total locomotion2.12.44.72.2-2.22.0-1.91.9-1.7-1.61.81.00.90.91.21.50.60.0
Intermittent access standard deviation0.50.50.80.8-0.80.7-0.80.7-0.7-0.70.50.90.90.90.70.7-0.50.0
Left kidney weight0.30.72.0-1.01.0-1.11.1-1.00.81.1-1.2-0.1-0.1-0.1-0.2-0.4-1.40.0
Right kidney weight2.36.38.8-2.62.6-2.82.8-2.82.82.9-3.0-2.6-2.6-2.6-2.6-2.30.20.0
Cocaine induced anxiety1.11.31.9-1.11.1-1.11.2-1.21.21.1-1.2-1.2-1.2-1.2-1.4-1.11.10.0
Post-drug Anxiety4.44.85.8-2.42.4-2.42.4-2.42.42.2-2.2-2.3-2.3-2.3-2.4-2.21.90.0
Baseline Anxiety0.80.81.5-1.01.0-1.10.8-1.11.01.2-0.9-1.0-1.0-1.0-0.8-0.90.30.0
Tail length0.00.10.40.6-0.60.5-0.50.5-0.4-0.20.50.1-0.0-0.00.20.2-0.10.0
Length with tail1.76.07.6-2.72.7-2.72.7-2.72.72.8-2.6-2.5-2.6-2.6-2.5-2.41.10.0
Length without tail5.712.617.3-4.14.1-4.24.1-4.14.04.0-4.1-3.2-3.3-3.3-3.4-3.21.00.0
Times rat made contact with spout0.20.21.60.4-0.40.2-0.50.2-0.3-0.00.20.40.40.40.40.4-1.30.0
Lifetime Intake1.92.13.61.9-1.91.6-1.71.6-1.6-1.31.31.41.31.31.51.3-1.40.0
Liver weight, left1.62.63.9-1.61.6-1.81.7-1.81.81.9-2.0-1.6-1.7-1.7-1.7-1.30.50.0
Liver weight, right1.42.43.6-1.61.6-1.61.6-1.61.61.9-1.8-1.7-1.8-1.8-1.6-1.30.20.0
Locomotor activity0.71.12.21.5-1.51.3-1.21.2-1.2-1.10.90.90.80.80.70.8-0.40.0
Locomotor testing distance2.03.45.32.3-2.32.2-2.12.2-2.1-2.01.91.71.71.71.71.5-0.70.0
Locomotor testing rearing1.62.43.91.9-1.91.9-2.01.9-1.7-1.91.81.31.31.21.21.30.60.0
Locomotion in novel chamber0.60.71.1-0.80.8-0.80.8-0.90.91.0-0.8-1.0-0.9-1.0-0.9-1.0-0.20.0
Locomotion in novel chamber post-restriction0.10.10.4-0.10.1-0.20.2-0.20.20.6-0.2-0.6-0.6-0.7-0.0-0.40.00.0
Fecal boli incidents, locomotor time 12.32.66.11.6-1.61.4-1.61.4-1.7-1.01.01.91.91.71.91.4-2.50.0
Change in fecal boli incidents, locomotor task1.31.22.8-1.21.2-1.21.2-1.11.10.9-1.0-1.0-1.0-1.0-1.1-1.11.70.0
Time >=10cm from walls, locomotor time 10.20.20.6-0.40.4-0.40.4-0.40.40.8-0.6-0.4-0.4-0.5-0.1-0.2-0.50.0
Bouts of movement, locomotor time 10.10.10.6-0.10.1-0.10.0-0.10.10.6-0.4-0.3-0.3-0.20.20.3-0.80.0
Total resting periods, locomotor time 10.20.20.80.4-0.40.4-0.50.4-0.50.00.20.30.30.30.70.9-0.90.0
Rest time, locomotor task time 10.30.30.80.6-0.60.5-0.70.5-0.6-0.20.40.50.50.40.80.9-0.70.0
Distance moved, locomotor task time 10.10.10.5-0.30.3-0.10.1-0.00.1-0.40.00.10.10.1-0.2-0.30.70.0
Vertical activity count, locomotor time 11.01.01.7-1.11.1-1.21.3-1.21.11.1-1.3-0.7-0.7-0.7-0.9-1.1-0.80.0
Time >=10cm from walls, locomotor time 20.40.40.91.0-1.00.8-0.70.7-0.7-0.50.40.60.60.60.60.6-0.60.0
Bouts of movement, locomotor time 22.52.73.8-1.61.6-1.71.6-1.71.81.7-1.7-1.9-1.9-2.0-1.8-1.30.90.0
Total resting periods, locomotor time 22.93.14.2-1.71.7-1.81.7-1.81.91.8-1.8-2.0-2.0-2.0-1.9-1.51.30.0
Rest time, locomotor task time 20.10.10.4-0.20.2-0.2-0.1-0.20.20.6-0.4-0.4-0.4-0.4-0.00.00.40.0
Distance moved, locomotor task time 20.10.10.40.2-0.20.3-0.20.4-0.4-0.70.50.50.50.50.30.3-0.10.0
Vertical activity count, locomotor time 20.10.11.00.0-0.0-0.10.4-0.20.20.3-0.3-0.4-0.4-0.4-0.3-0.4-1.00.0
Light reinforcement 11.83.25.42.3-2.32.3-2.22.3-2.0-2.22.11.31.41.41.31.30.10.0
Light reinforcement 20.60.81.61.3-1.31.1-1.01.0-1.0-0.90.80.80.90.80.70.80.00.0
Bone: marrow area6.313.817.3-4.24.2-4.14.1-4.04.13.8-3.8-3.8-3.8-3.8-3.8-3.62.50.0
Bone: maximum diameter3.56.58.2-2.52.5-2.72.7-2.82.82.9-2.9-2.8-2.8-2.8-2.8-2.6-0.30.0
Bone: maximum force11.419.726.4-5.15.1-5.05.1-5.04.94.8-4.8-4.3-4.3-4.3-4.2-4.22.50.0
Bone: maximum moment11.519.927.9-5.35.3-5.15.2-5.04.94.8-4.8-4.2-4.2-4.2-4.2-4.22.70.0
Mean time between licks in bursts0.20.21.30.1-0.10.3-0.20.4-0.4-0.60.50.50.50.50.40.11.20.0
Mean num. licks in bursts0.40.53.1-0.10.1-0.10.20.1-0.3-0.10.11.01.01.01.00.6-1.80.0
Cd content in liver0.40.40.80.9-0.90.8-0.90.7-0.7-0.60.60.60.60.60.50.50.00.0
Co content in liver0.30.31.21.1-1.10.6-0.90.4-0.4-0.10.10.10.20.10.10.5-0.80.0
Cu content in liver0.70.81.5-0.70.7-1.00.6-1.11.01.1-1.2-1.1-1.0-1.0-1.1-0.60.70.0
Fe content in liver0.20.31.00.8-0.80.6-1.00.4-0.5-0.30.30.30.40.30.30.6-0.40.0
K content in liver0.30.30.6-0.30.3-0.50.4-0.60.50.8-0.7-0.5-0.6-0.6-0.5-0.2-0.10.0
Mg content in liver0.10.10.90.1-0.10.0-0.00.0-0.10.2-0.00.10.0-0.00.1-0.1-1.00.0
Mn content in liver0.10.10.2-0.40.4-0.20.2-0.10.20.0-0.1-0.3-0.3-0.3-0.3-0.30.10.0
Na content in liver0.10.11.70.3-0.30.2-0.50.1-0.1-0.1-0.0-0.1-0.1-0.1-0.20.11.30.0
Rb content in liver0.20.20.60.8-0.80.6-0.80.5-0.5-0.10.30.10.1-0.00.10.5-0.60.0
Se content in liver0.60.83.20.9-0.90.8-0.90.8-0.8-0.70.70.80.80.80.80.6-1.80.0
Sr content in liver0.60.61.0-0.50.5-0.60.6-0.70.71.0-0.8-0.8-0.8-1.0-0.8-1.0-1.00.0
Zn content in liver1.01.12.51.6-1.61.4-1.61.3-1.2-0.81.10.70.60.60.80.9-0.50.0
Bone: minimum diameter7.814.517.8-4.14.1-4.24.2-4.24.24.1-4.1-4.0-4.0-4.0-4.0-3.81.60.0
Time in familiar zone, hab. session 10.50.40.90.5-0.50.5-0.60.6-0.7-0.60.60.90.90.90.90.7-0.40.0
Time in novel zone, hab. session 10.60.61.2-0.50.5-0.50.5-0.60.70.6-0.6-1.1-1.1-1.1-1.1-0.71.00.0
Total zone transitions, hab. session 10.30.40.60.7-0.70.7-0.70.7-0.6-0.60.70.50.50.50.50.70.80.0
Total locomotion distance, hab. session 10.00.10.4-0.20.2-0.10.20.0-0.0-0.10.10.20.20.20.2-0.20.60.0
Locomotion velocity, hab. session 10.00.10.6-0.30.3-0.10.3-0.10.1-0.00.00.10.10.10.0-0.20.80.0
Time in familiar zone, hab. session 20.10.10.3-0.60.6-0.50.6-0.50.40.4-0.4-0.0-0.0-0.00.0-0.2-0.30.0
Time in novel zone, hab. session 20.20.21.50.5-0.50.5-0.50.5-0.3-0.50.4-0.3-0.3-0.3-0.30.11.20.0
Total zone transitions, hab. session 20.30.40.80.6-0.60.6-0.60.6-0.7-0.40.50.80.80.80.90.6-0.50.0
Total locomotion distance, hab. session 20.10.20.60.1-0.10.3-0.20.4-0.5-0.40.40.70.70.70.70.10.10.0
Locomotion velocity, hab. session 20.10.10.4-0.10.10.1-0.10.2-0.3-0.20.20.60.60.60.6-0.1-0.10.0
Novel to familiar place preference ratio1.81.92.8-1.31.3-1.41.1-1.41.51.3-1.3-1.7-1.7-1.7-1.7-1.11.20.0
Novelty place preference1.41.42.3-1.11.1-1.10.9-1.21.31.1-1.1-1.5-1.5-1.5-1.5-0.91.20.0
Time in novel zone, NPP test1.21.32.2-1.01.0-1.00.8-1.01.21.0-1.0-1.5-1.5-1.5-1.5-0.81.30.0
Total zone transitions, NPP test1.21.72.51.4-1.41.3-1.31.3-1.4-1.11.21.51.51.51.61.3-0.80.0
Total locomotion distance, NPP test1.62.13.21.3-1.31.5-1.41.6-1.6-1.61.61.81.81.81.81.1-0.40.0
Locomotion velocity, NPP test0.91.32.11.0-1.01.1-1.01.1-1.2-1.11.21.41.41.41.40.8-0.60.0
Intraocular pressure6.18.511.63.2-3.23.3-3.23.3-3.2-3.43.42.92.92.92.92.6-0.50.0
Delta distance traveled before/after self-admin0.10.10.2-0.30.3-0.30.3-0.20.10.3-0.20.20.30.20.30.1-0.40.0
Delta ambulatory time before/after self-admin0.00.00.4-0.00.0-0.10.1-0.10.00.2-0.10.10.20.20.20.1-0.70.0
Parametrial fat weight1.93.74.62.1-2.12.0-2.12.0-2.1-1.91.92.02.02.02.11.9-1.70.0
Pavlov. Cond. lever latency0.30.34.4-0.40.4-0.20.3-0.00.1-0.20.2-0.0-0.0-0.0-0.00.32.10.0
Pavlov. Cond. magazine entry latency0.10.11.2-0.00.0-0.00.10.0-0.10.00.00.40.40.40.40.2-1.10.0
Pavlov. Cond. change in total contacts0.10.21.6-0.00.0-0.20.1-0.30.20.3-0.4-0.2-0.2-0.2-0.3-0.4-1.30.0
Pavlov. Cond. index score0.20.32.0-0.00.0-0.20.1-0.30.30.6-0.6-0.4-0.4-0.4-0.4-0.5-1.40.0
Pavlov. Cond. latency score0.20.32.90.0-0.0-0.10.1-0.30.20.5-0.5-0.3-0.3-0.3-0.3-0.5-1.70.0
Pavlov. Cond. lever contacts0.50.53.90.9-0.90.6-0.80.5-0.6-0.30.20.40.40.40.40.3-2.00.0
Pavlov. Cond. magazine entry number0.10.11.1-0.20.2-0.10.2-0.10.1-0.10.0-0.2-0.2-0.2-0.2-0.11.00.0
Pavlov. Cond. intertrial magazine entries0.40.50.70.6-0.60.6-0.60.6-0.7-0.70.60.80.80.80.90.8-0.80.0
Pavlov. Cond. lever-magazine prob. diff.0.40.41.9-0.30.3-0.50.4-0.60.60.9-0.9-0.6-0.6-0.6-0.6-0.7-1.40.0
Pavlov. Cond. response bias0.20.22.40.3-0.30.2-0.30.2-0.3-0.10.10.40.40.40.40.2-1.50.0
Pavlov. Cond. lever latency0.00.00.0-0.10.1-0.10.2-0.10.1-0.00.00.00.00.0-0.0-0.00.10.0
Pavlov. Cond. magazine entry latency0.80.91.5-1.11.1-1.11.2-1.11.10.9-1.0-0.9-0.8-0.8-0.9-0.90.10.0
Pavlov. Cond. change in total contacts1.11.52.5-1.31.3-1.41.2-1.51.41.5-1.6-1.2-1.2-1.2-1.2-1.2-0.10.0
Pavlov. Cond. index score0.40.50.7-0.80.8-0.80.7-0.80.80.8-0.8-0.7-0.7-0.7-0.7-0.70.10.0
Pavlov. Cond. latency score0.40.50.8-0.80.8-0.90.8-0.90.80.9-0.9-0.7-0.7-0.7-0.7-0.7-0.20.0
Pavlov. Cond. lever contacts0.10.10.20.4-0.40.4-0.50.3-0.4-0.30.30.30.40.40.40.3-0.30.0
Pavlov. Cond. magazine entry number2.02.43.01.6-1.61.7-1.71.7-1.7-1.61.71.71.71.71.71.5-0.70.0
Pavlov. Cond. intertrial magazine entries4.35.67.02.6-2.62.6-2.62.6-2.6-2.32.52.32.32.32.52.1-2.20.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.2-1.01.0-1.11.0-1.11.11.0-1.1-1.0-1.0-1.0-1.0-1.00.40.0
Pavlov. Cond. response bias0.00.00.00.1-0.10.0-0.10.0-0.0-0.1-0.00.10.10.10.00.00.10.0
Time in closed arm before self-admin1.61.83.4-1.21.2-1.31.3-1.31.41.0-1.2-1.6-1.5-1.5-1.5-1.21.80.0
Time in closed arm after self-admin0.50.50.8-0.90.9-0.80.9-0.80.80.6-0.8-0.5-0.6-0.7-0.6-0.60.30.0
Time in open arm before self-admin0.80.81.4-1.01.0-0.90.8-0.90.91.2-0.9-1.0-1.1-1.1-0.9-0.8-0.30.0
Time in open arm after self-admin0.20.20.40.6-0.60.5-0.60.5-0.5-0.40.60.10.20.20.30.40.50.0
Bone: periosteal estimation10.020.726.2-5.05.0-5.05.1-5.05.05.0-5.0-4.6-4.6-4.6-4.6-4.51.20.0
Bone: periosteal perimeter8.313.817.9-4.14.1-4.24.2-4.24.14.2-4.2-3.7-3.7-3.7-3.7-3.60.20.0
Bone: post-yield work7.39.912.3-3.53.5-3.43.5-3.33.43.1-3.1-3.2-3.2-3.2-3.2-2.93.00.0
Progressive ratio test 1 active lever presses3.13.35.62.4-2.42.2-2.12.1-2.0-1.81.91.61.51.51.71.7-0.80.0
Progressive ratio test 1 breakpoint2.83.05.32.3-2.32.1-2.02.0-1.9-1.71.81.51.41.41.61.6-0.80.0
Progressive ratio test 1 inactive lever presses2.62.94.72.2-2.22.0-2.02.0-1.9-1.71.91.41.31.31.71.9-0.00.0
Progressive ratio test 2 active lever presses1.51.63.21.8-1.81.6-1.81.5-1.4-1.21.31.00.90.90.91.00.30.0
Progressive ratio test 2 breakpoint2.02.24.12.0-2.01.9-2.01.8-1.7-1.51.51.31.11.11.11.20.30.0
Progressive ratio test 2 inactive lever presses2.02.33.61.9-1.91.8-1.81.7-1.7-1.81.61.51.41.41.31.40.30.0
Incentive Sensitization - Responses0.10.10.30.1-0.1-0.10.1-0.20.20.2-0.4-0.3-0.4-0.4-0.5-0.50.20.0
Incentive Sensitization - Breakpoint0.00.00.20.2-0.20.0-0.1-0.00.10.1-0.3-0.2-0.2-0.2-0.4-0.40.20.0
Sum of active levers in priming session hrs 5-60.10.10.40.1-0.10.2-0.20.3-0.3-0.40.40.30.40.30.40.40.60.0
Progressive ratio0.10.21.40.1-0.10.2-0.10.2-0.3-0.20.30.40.40.40.50.2-1.20.0
Food seeking constrained by brief footshock0.30.31.40.7-0.70.6-0.70.5-0.5-0.10.60.20.20.20.40.8-1.20.0
Seeking ratio, punishment vs. effort0.00.10.10.1-0.10.0-0.2-0.00.10.2-0.1-0.4-0.4-0.3-0.40.10.40.0
Retroperitoneal fat weight0.51.75.21.4-1.41.2-1.31.1-1.3-0.90.61.41.41.41.41.2-2.30.0
Reaction time number correct1.01.52.8-1.61.6-1.41.7-1.31.30.9-1.1-1.0-0.9-0.8-1.2-1.41.10.0
Reaction time mean minus median7.910.413.73.3-3.33.3-3.43.4-3.5-3.33.23.73.73.63.53.1-2.20.0
Reaction time mean minus median AUC5.77.410.02.8-2.82.8-2.92.9-3.0-2.82.73.23.13.13.02.7-1.40.0
Reaction time num false alarms1.72.33.31.4-1.41.6-1.51.6-1.6-1.81.81.81.81.81.71.2-0.80.0
Reaction time num false alarms AUC2.63.65.51.7-1.71.9-1.81.9-2.0-2.22.12.32.32.32.21.6-0.80.0
Reaction time trials correct on left1.01.52.8-1.61.6-1.41.7-1.31.30.9-1.1-1.0-0.9-0.8-1.2-1.41.10.0
Reaction time trials on left0.81.12.2-1.51.5-1.21.5-1.11.10.7-0.9-0.8-0.7-0.7-1.0-1.31.00.0
Reaction time mean0.60.81.21.0-1.00.9-1.10.9-0.9-0.60.71.00.90.90.90.8-1.10.0
Reaction time mean AUC0.40.51.10.7-0.70.6-0.90.6-0.7-0.40.50.80.80.80.70.6-1.10.0
Median of all reaction times0.00.10.3-0.00.0-0.2-0.0-0.20.20.5-0.3-0.2-0.2-0.2-0.2-0.3-0.60.0
Reaction time omissions8.511.614.23.7-3.73.7-3.63.7-3.8-3.53.63.53.53.53.63.1-2.30.0
Reaction time false alarm rate2.63.64.61.9-1.92.0-2.12.0-2.0-2.02.02.12.12.02.21.8-1.10.0
Reaction time premature initiation rate4.66.110.43.2-3.23.0-2.92.8-2.7-2.62.72.22.12.22.12.3-0.40.0
Reaction time premature initiations2.23.14.82.2-2.22.1-1.92.0-1.9-2.12.01.61.61.71.41.40.20.0
Std. dev. reaction times5.67.910.02.9-2.93.0-3.13.0-3.1-2.82.83.23.13.13.12.7-1.80.0
Reaction time trials completed0.81.12.2-1.51.5-1.21.5-1.11.10.7-0.9-0.8-0.7-0.7-1.0-1.31.00.0
Reaction time trials AUC1.31.93.4-1.81.8-1.61.8-1.51.51.1-1.2-1.2-1.1-1.0-1.3-1.61.20.0
Run reversals in cocaine runway, females0.00.00.10.1-0.10.1-0.10.1-0.0-0.30.00.00.10.1-0.20.40.30.0
Run reversals in cocaine runway, males1.21.21.51.2-1.21.2-1.21.2-1.2-1.21.21.01.01.01.10.9-0.80.0
Latency to leave start box in cocaine runway0.00.00.50.1-0.10.1-0.10.1-0.1-0.00.20.0-0.0-0.00.10.0-0.70.0
Latency to leave start box in cocaine runway, F1.31.52.51.4-1.41.5-1.31.4-1.4-1.41.61.11.01.01.11.0-0.30.0
Latency to leave start box in cocaine runway, M1.51.42.1-1.41.4-1.41.4-1.41.31.4-1.4-1.1-1.1-1.1-1.0-1.0-0.40.0
Std. dev. time between licks in bursts0.60.71.31.1-1.11.1-1.01.1-1.0-1.01.00.70.70.70.60.40.00.0
Total sessions with >9 infusions0.60.72.61.3-1.30.9-0.80.8-0.8-0.50.50.40.40.40.60.6-1.60.0
Short access day 1 total inactive lever presses1.01.12.31.4-1.41.3-1.51.2-1.2-1.01.00.90.80.80.91.0-0.20.0
Short access day 10 total inactive lever presses0.40.54.00.4-0.40.6-0.70.6-0.4-0.80.70.20.30.30.20.52.00.0
Short access day 1 total infusions0.10.10.60.4-0.40.1-0.30.1-0.10.2-0.1-0.1-0.2-0.20.00.1-0.70.0
Short access day 10 total infusions0.80.92.51.3-1.31.0-1.00.9-0.9-0.70.50.80.80.80.90.9-1.60.0
Short access total infusions0.40.41.81.0-1.00.7-0.70.6-0.6-0.30.30.40.40.30.50.4-1.30.0
Short access day 1 locomotion0.10.10.30.5-0.50.3-0.40.2-0.10.20.1-0.2-0.3-0.5-0.20.2-0.10.0
Short access day 10 total locomotion0.20.21.50.4-0.40.4-0.40.4-0.2-0.30.5-0.4-0.5-0.5-0.00.31.20.0
Short access total locomotion0.30.30.70.9-0.90.7-0.70.6-0.4-0.20.5-0.1-0.1-0.30.10.50.70.0
One hour access (0.3 mA shock)0.20.31.00.8-0.80.5-0.50.4-0.5-0.50.20.50.50.50.30.4-1.00.0
Compulsive drug intake0.70.71.3-1.21.2-1.00.9-0.90.90.7-0.7-0.6-0.6-0.6-0.7-0.80.70.0
One hour access (shock baseline)0.10.21.00.7-0.70.4-0.30.3-0.3-0.1-0.00.20.10.10.10.2-1.00.0
Social response proportion0.20.20.30.5-0.50.3-0.40.3-0.4-0.40.40.50.50.50.40.50.20.0
Social responses6.48.211.33.3-3.33.2-3.23.2-3.1-3.43.32.82.82.92.62.7-0.30.0
Social time0.20.30.80.2-0.20.1-0.10.1-0.3-0.40.20.90.90.80.50.8-0.60.0
Soleus weight0.61.62.2-1.31.3-1.31.3-1.31.41.4-1.3-1.5-1.5-1.5-1.5-1.10.60.0
Bone: stiffness13.721.628.6-5.35.3-5.25.3-5.25.15.1-5.1-4.5-4.5-4.5-4.5-4.62.00.0
Tibialis anterior weight1.24.17.3-1.41.4-1.91.3-2.12.22.3-2.5-2.6-2.6-2.6-2.7-1.70.90.0
Time to tail flick, vehicle, before self-admin1.01.11.70.9-0.91.0-0.91.1-1.1-1.21.11.31.31.31.20.8-0.40.0
Time to tail flick, vehicle, after self-admin0.50.52.7-0.50.5-0.50.6-0.50.60.3-0.5-0.8-0.8-0.8-0.9-0.51.70.0
Time to tail flick, test, before self-admin0.40.30.80.6-0.60.6-0.50.6-0.6-0.60.50.60.60.60.60.9-0.40.0
Time to tail flick, test, after self-admin0.10.20.3-0.50.5-0.40.5-0.40.40.5-0.4-0.4-0.4-0.4-0.3-0.2-0.30.0
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.60.6-0.70.6-0.70.80.7-0.7-0.9-0.9-0.8-0.8-0.60.80.0
Delta time to tail flick, test, before/after SA0.20.20.3-0.50.5-0.40.4-0.40.40.5-0.3-0.6-0.6-0.5-0.3-0.5-0.10.0
Tibia length6.317.922.1-4.54.5-4.64.6-4.74.74.6-4.6-4.4-4.4-4.4-4.4-4.22.00.0
Ambulatory time before self-admin2.93.04.42.0-2.02.1-2.12.0-1.9-2.02.01.51.41.41.51.60.60.0
Ambulatory time after self-admin1.21.32.01.4-1.41.4-1.41.4-1.3-1.31.31.01.01.00.91.00.30.0
Bone: tissue strength1.00.93.4-1.21.2-1.01.1-0.90.90.7-0.7-0.8-0.8-0.8-0.8-0.71.90.0
Total heroin consumption2.32.74.6-1.51.5-1.51.5-1.51.71.6-1.6-2.0-2.0-2.1-2.1-1.31.60.0
Bone: trabecular number4.16.411.9-3.43.4-3.23.3-3.02.82.9-2.9-1.7-1.7-1.7-1.7-2.4-0.30.0
Bone: trabecular spacing1.31.73.71.9-1.91.7-1.71.6-1.4-1.61.60.70.70.70.71.10.30.0
Bone: trabecular thickness0.20.30.90.3-0.30.3-0.30.3-0.5-0.30.30.70.70.70.70.3-0.90.0
Bone: trabecular tissue density0.00.10.20.2-0.20.3-0.20.3-0.2-0.30.3-0.1-0.1-0.1-0.1-0.20.40.0
Water consumed over 24 hours0.00.00.3-0.20.2-0.10.3-0.0-0.00.00.10.20.20.20.2-0.1-0.50.0
Number of responses in last shaping day0.30.31.5-0.00.0-0.20.0-0.30.40.5-0.4-0.7-0.7-0.8-0.7-0.41.20.0