Hub : Genes

Fkbp11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA isoform ratio XM_006257344.5 0.06 0.05 1.8e-04 0.04 0.04 0.04 0.04 3.0e-04 2.3e-04 3.9e-04 3.3e-04
2 Liver intron excision ratio chr7_131753830_131754041 0.23 0.11 0.0e+00 0.26 0.27 0.27 0.27 2.8e-29 7.9e-30 9.5e-30 1.3e-29
3 pVTA alternative TSS NM_001013105.2 0.04 0.03 1.3e-03 0.02 0.02 0.02 0.01 4.2e-03 1.2e-02 1.2e-02 2.8e-02
4 Liver alternative TSS NM_001013105.2 0.14 0.08 0.0e+00 0.16 0.17 0.16 0.17 1.1e-17 1.1e-18 5.8e-18 3.8e-18
5 pVTA alternative TSS XM_006257344.5 0.05 0.04 4.4e-04 0.03 0.03 0.03 0.03 1.5e-03 2.4e-03 2.4e-03 3.4e-03
6 IC gene expression Fkbp11 0.09 0.07 2.9e-03 0.03 0.02 0.03 0.01 2.5e-02 4.6e-02 2.0e-02 8.4e-02
7 Brain gene expression Fkbp11 0.08 0.05 2.0e-07 0.07 0.06 0.04 0.06 6.4e-07 4.1e-06 6.7e-05 1.9e-06
8 Liver isoform ratio NM_001013105.2 0.15 0.08 0.0e+00 0.2 0.2 0.19 0.19 1.3e-21 1.7e-21 1.5e-20 4.5e-21
9 Liver isoform ratio XM_063263376.1 0.1 0.06 1.6e-15 0.13 0.13 0.12 0.12 2.1e-14 6.1e-14 1.0e-13 9.8e-14
10 Liver intron excision ratio chr7_131753357_131753765 0.08 0.05 6.5e-10 0.09 0.08 0.08 0.08 8.8e-10 4.7e-09 3.2e-09 1.7e-09
11 BLA gene expression Fkbp11 0.06 0.05 1.8e-03 0.04 0.05 0.04 0.04 2.1e-03 9.5e-04 3.1e-03 2.0e-03
12 Liver alternative TSS XM_063263378.1 0.11 0.07 1.7e-16 0.13 0.14 0.14 0.14 4.2e-14 8.1e-15 7.5e-15 9.8e-15
13 pVTA gene expression Fkbp11 0.14 0.09 6.9e-07 0.08 0.07 0.07 0.08 5.6e-07 4.8e-06 4.2e-06 7.3e-07
14 PL gene expression Fkbp11 0.03 0.03 1.9e-03 0.02 0.02 0.02 0.02 1.8e-03 4.7e-03 2.2e-03 3.7e-03
15 Liver gene expression Fkbp11 0.13 0.08 2.8e-08 0.06 0.05 0.06 0.06 7.4e-07 6.8e-06 1.8e-07 8.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density8.715.119.44.4-4.1-4.3-4.04.14.34.0-4.04.04.03.93.73.13.12.5
Area under the delay curve0.70.91.51.2-1.0-0.8-0.90.91.21.0-1.11.11.00.90.80.70.7-0.1
BMI with tail6.622.627.95.2-5.0-4.8-4.84.95.34.9-5.05.14.94.74.84.14.03.4
BMI without tail2.06.17.72.4-2.5-2.3-2.42.62.42.5-2.62.82.42.42.52.42.32.2
Body weight6.930.434.75.9-5.7-5.3-5.65.85.95.8-5.75.85.85.55.55.04.94.2
Weight adjusted by age3.14.77.21.6-2.0-1.9-2.12.01.52.1-1.92.22.02.22.62.62.42.7
Bone surface10.318.823.14.8-4.6-4.7-4.54.54.74.5-4.54.44.54.44.23.63.72.7
Bone volume8.014.317.84.2-4.0-4.1-3.94.04.14.0-3.93.74.03.83.73.13.22.5
Breakpoint value in progressive ratio session1.21.42.11.2-1.3-1.1-1.31.21.31.3-1.11.21.11.21.41.11.01.3
Number of licking bursts0.20.30.9-0.90.40.70.3-0.3-0.9-0.30.30.0-0.3-0.20.00.30.40.9
Context. condit. distance diff. score0.40.51.00.5-0.6-0.5-0.60.70.60.6-0.60.90.60.70.70.80.71.0
Locomotion velocity, session 10.91.01.5-1.21.01.01.0-1.1-1.2-1.11.0-1.2-1.0-0.9-0.8-0.6-0.6-0.6
Locomotion distance, session 13.24.06.1-1.61.91.82.0-1.9-1.5-1.91.9-2.3-1.9-2.1-2.1-2.1-2.2-2.5
Locomotion velocity, session 20.40.41.3-0.40.60.40.6-0.6-0.3-0.60.7-0.9-0.6-0.6-0.6-0.7-0.7-1.1
Locomotion distance, session 22.73.85.2-1.51.91.71.9-1.9-1.5-1.91.9-2.3-1.9-2.0-1.9-2.1-2.2-2.3
Locomotion velocity, session 34.14.65.6-2.02.22.12.2-2.1-1.9-2.12.1-2.4-2.1-2.2-2.3-2.2-2.2-2.3
Locomotion distance, session 35.05.46.4-2.22.42.22.4-2.4-2.3-2.32.3-2.5-2.3-2.4-2.4-2.3-2.3-2.3
Stereotopy head waving bouts, day 31.21.42.01.0-1.2-1.4-1.31.20.91.1-1.10.91.11.31.41.41.41.0
Stereotopy head waving duration, day 30.50.61.00.7-0.8-1.0-0.90.70.60.7-0.70.40.70.90.90.90.80.6
Locomotion velocity, session 70.10.10.3-0.50.40.30.3-0.3-0.5-0.20.1-0.1-0.1-0.30.2-0.2-0.00.4
Locomotion distance, session 71.01.22.2-1.51.31.31.3-1.2-1.5-1.11.0-0.8-1.1-1.2-0.7-0.9-0.8-0.0
Stereotopy head waving bouts, day 71.71.93.40.9-1.3-1.3-1.41.40.81.3-1.21.31.31.51.61.81.81.8
Stereotopy head waving duration, day 71.21.42.40.8-1.2-1.1-1.21.20.81.1-1.11.11.11.31.21.51.51.4
Locomotion velocity, session 80.00.00.10.1-0.10.1-0.10.20.30.2-0.10.10.20.10.10.30.2-0.3
Locomotion distance, session 81.21.82.6-1.11.31.31.4-1.3-0.8-1.41.4-1.2-1.4-1.4-1.4-1.5-1.6-1.3
Degree of sensitization distance0.90.92.50.6-0.8-0.7-0.80.80.60.8-0.91.20.80.91.21.01.01.6
Degree of sensitization stereotypy0.40.41.40.1-0.5-0.3-0.50.60.00.5-0.40.60.50.60.71.01.01.2
Conditioned locomotion0.20.20.8-0.4-0.1-0.2-0.30.1-0.50.1-0.1-0.00.10.40.60.90.90.9
Cocaine response after cond. corrected0.30.42.50.50.10.00.2-0.10.60.0-0.1-0.2-0.0-0.4-0.6-0.9-0.9-1.6
Cocaine response after cond. not corrected1.01.23.4-0.40.90.81.0-0.9-0.3-0.90.9-0.9-0.9-1.1-1.4-1.5-1.6-1.8
Cocaine response before conditioning4.04.76.7-2.52.32.12.2-2.3-2.5-2.42.6-2.0-2.5-2.1-2.0-1.8-1.8-0.7
Saline control response0.00.00.10.1-0.0-0.2-0.0-0.10.2-0.10.20.2-0.1-0.0-0.0-0.2-0.30.3
Bone: connectivity density5.78.812.43.5-3.2-3.4-3.13.13.53.1-3.13.13.13.02.72.22.31.6
Bone: cortical apparent density0.20.30.6-0.80.60.40.5-0.7-0.8-0.60.6-0.5-0.6-0.5-0.3-0.3-0.20.4
Bone: cortical area11.417.619.74.2-4.3-4.1-4.34.44.24.4-4.44.24.44.34.34.04.03.4
Bone: cortical porosity1.21.32.1-1.21.10.81.0-1.2-1.2-1.21.3-1.4-1.3-1.1-1.1-1.0-1.0-0.7
Bone: cortical porosity1.41.52.2-1.41.20.91.2-1.3-1.5-1.41.4-1.5-1.4-1.2-1.2-1.0-1.0-0.7
Bone: cortical thickness4.98.29.72.9-2.9-2.5-2.93.12.93.1-3.12.73.12.92.92.82.72.2
Bone: cortical thickness0.40.50.90.6-0.6-0.3-0.50.80.60.8-0.80.70.80.61.00.60.50.9
Bone: cortical tissue density0.30.40.8-0.90.70.50.6-0.8-0.9-0.80.7-0.6-0.7-0.6-0.4-0.4-0.30.3
Condit. Reinf. active minus inactive responses0.20.21.00.00.30.20.3-0.3-0.0-0.30.3-0.8-0.3-0.4-0.5-0.7-0.7-1.0
Condit. Reinf. active-inactive response ratio0.20.20.50.7-0.4-0.6-0.40.40.60.3-0.4-0.10.40.30.2-0.1-0.1-0.5
Condit. Reinf. active responses0.70.81.7-0.60.80.80.9-0.8-0.6-0.90.8-1.3-0.9-0.9-0.9-1.1-1.1-1.2
Condit. Reinf. inactive responses2.43.03.7-1.91.81.91.8-1.8-1.8-1.81.8-1.7-1.9-1.8-1.6-1.5-1.6-1.0
Incentive salience index mean0.00.10.20.4-0.2-0.1-0.20.30.30.2-0.3-0.20.20.10.1-0.0-0.1-0.4
Condit. Reinf. lever presses0.20.30.60.6-0.5-0.3-0.50.70.50.7-0.80.20.70.50.50.50.50.0
Condit. Reinf. active minus inactive responses0.00.10.3-0.30.20.10.2-0.2-0.4-0.20.2-0.0-0.2-0.10.0-0.1-0.10.5
Condit. Reinf. active-inactive response ratio0.30.30.4-0.50.60.60.6-0.5-0.5-0.60.5-0.6-0.6-0.6-0.4-0.6-0.7-0.2
Condit. Reinf. active responses0.20.30.6-0.70.60.40.6-0.6-0.8-0.60.6-0.3-0.6-0.5-0.5-0.5-0.40.3
Condit. Reinf. inactive responses0.60.71.5-1.10.90.80.8-0.9-1.2-1.01.0-0.6-1.0-0.8-0.9-0.6-0.50.0
Condit. Reinf. lever presses0.00.00.20.2-0.1-0.2-0.10.10.20.1-0.00.40.10.00.2-0.2-0.10.4
Condit. Reinf. lever reinforcers received0.50.71.1-0.90.90.70.9-0.9-1.0-0.90.9-0.6-0.9-0.8-0.8-0.8-0.70.0
Conditioned reinforcement - actives0.71.21.9-1.31.21.41.2-1.2-1.3-1.01.0-1.1-0.8-1.1-1.1-0.8-0.8-0.7
Conditioned reinforcement - inactives3.14.66.0-2.22.32.52.3-2.1-2.2-2.12.0-2.3-2.0-2.2-2.2-2.0-1.9-1.7
Conditioned locomotion0.20.20.7-0.80.50.40.4-0.5-0.8-0.50.5-0.3-0.5-0.3-0.30.0-0.10.5
Patch foraging indifference point 0 sec1.93.54.7-1.81.92.01.9-1.9-1.8-1.81.9-1.8-1.9-1.9-2.2-1.8-1.9-1.6
Patch foraging indifference point AUC0.81.11.5-1.21.11.01.1-1.2-1.1-1.21.2-0.7-1.2-1.0-1.0-1.0-0.9-0.4
Delay disc. indifference point, 0s delay1.11.21.81.0-1.1-1.1-1.20.81.01.0-1.31.01.11.21.31.11.40.8
Delay disc. indifference point, 16s delay0.91.01.41.0-1.0-0.8-1.01.11.01.1-1.11.11.21.01.01.01.00.6
Delay disc. indifference point, 2s delay1.01.11.51.1-1.1-1.2-1.11.01.11.1-1.01.10.91.11.01.00.90.7
Delay disc. indifference point, 24s delay1.01.21.51.1-1.1-0.9-1.11.01.21.2-1.11.21.21.11.01.01.00.8
Delay disc. indifference point, 4s delay0.30.41.01.0-0.6-0.6-0.50.61.00.6-0.70.60.60.40.30.10.2-0.7
Delay disc. indifference point, 8s delay2.02.33.81.9-1.6-1.4-1.51.61.91.6-1.71.71.61.51.31.21.10.3
Indifference point function ln k2.84.95.52.1-2.3-2.3-2.32.32.02.2-2.22.12.12.32.32.32.12.1
Indifference point function log k2.84.95.52.1-2.3-2.3-2.32.32.02.2-2.22.12.12.32.32.32.12.1
Patch foraging total patch changes 0 sec1.83.54.6-1.81.92.01.9-1.9-1.8-1.82.0-1.8-1.9-1.9-2.1-1.8-1.9-1.4
Patch foraging total patch changes 12 sec2.12.73.7-1.81.71.91.7-1.6-1.8-1.61.9-1.5-1.7-1.6-1.8-1.3-1.3-1.1
Patch foraging total patch changes 18 sec3.55.46.9-2.62.42.32.4-2.6-2.6-2.62.4-2.0-2.5-2.3-2.3-2.2-1.9-1.3
Patch foraging total patch changes 24 sec1.42.43.9-1.91.71.81.6-1.5-2.0-1.61.6-1.4-1.6-1.5-1.6-1.1-1.1-0.7
Patch foraging total patch changes 6 sec2.43.74.5-1.92.02.02.0-2.0-1.9-1.92.1-1.8-1.9-2.0-2.1-1.8-1.9-1.5
Patch foraging time to switch 0 sec1.63.34.4-1.91.91.91.9-1.8-1.9-1.92.1-1.8-1.8-1.9-1.9-1.6-1.6-1.3
Patch foraging water rate 0 sec2.65.46.72.3-2.4-2.3-2.42.32.32.4-2.62.22.42.42.42.22.31.8
Patch foraging water rate 12 sec2.55.36.12.2-2.3-2.5-2.42.42.02.2-2.42.22.32.42.42.42.32.2
Patch foraging water rate 18 sec0.40.61.00.7-0.7-0.5-0.70.80.61.0-0.90.70.90.80.70.80.80.8
Patch foraging water rate 24 sec3.24.55.81.8-2.1-2.1-2.22.01.72.0-2.02.02.12.22.42.42.42.3
Patch foraging water rate 6 sec4.46.47.72.3-2.5-2.6-2.62.62.22.6-2.72.22.52.62.82.72.62.3
Seeking ratio, delayed vs. immediate footshock0.20.20.80.8-0.4-0.3-0.20.30.90.4-0.40.30.40.10.1-0.5-0.3-0.8
Distance traveled before self-admin0.60.81.5-1.20.91.00.9-1.0-1.2-0.90.9-1.0-1.0-0.8-0.7-0.4-0.5-0.3
Distance traveled after self-admin0.30.30.6-0.30.50.50.6-0.6-0.3-0.70.5-0.8-0.6-0.6-0.4-0.8-0.8-0.6
Extensor digitorum longus weight4.517.820.54.1-4.3-3.7-4.24.54.04.5-4.54.44.54.34.04.34.33.6
Bone: elastic displacement4.55.26.7-2.32.32.22.3-2.4-2.3-2.42.4-2.6-2.4-2.3-2.2-2.2-2.1-1.9
Bone: elastic work0.00.00.2-0.10.1-0.20.0-0.2-0.1-0.20.1-0.5-0.1-0.10.1-0.2-0.1-0.2
Bone: endosteal estimation7.316.118.34.0-4.2-4.3-4.24.13.84.0-4.04.24.04.24.23.83.83.6
Bone: endosteal perimeter7.115.117.53.9-4.0-3.8-4.04.23.84.0-3.94.13.94.03.83.73.63.4
Epididymis fat weight0.72.53.41.7-1.6-1.8-1.61.41.71.5-1.81.51.71.61.81.21.41.0
Delta time in closed arm before/after self-admin0.10.10.60.10.20.20.2-0.30.2-0.20.2-0.1-0.1-0.3-0.4-0.5-0.7-0.8
Delta time in open arm before/after self-admin0.80.81.4-1.21.01.10.9-0.9-1.2-0.90.8-1.0-0.9-0.8-0.6-0.6-0.5-0.1
Diff in mean of infusions in LGA sessions0.81.01.61.2-1.1-1.2-1.01.01.21.3-1.00.91.11.00.90.80.70.1
Delay discount exponential model param0.70.71.4-1.10.90.80.8-0.9-1.2-0.91.0-1.0-0.9-0.8-0.7-0.6-0.60.1
Extinction: sum of active levers before priming1.41.52.21.1-1.3-1.3-1.41.21.01.1-1.21.01.31.41.51.31.41.1
Active lever presses in extinction session 61.01.01.61.3-1.1-1.1-1.11.11.31.0-0.90.81.01.01.00.70.60.7
Bone: final force10.116.119.04.4-4.3-4.2-4.24.24.34.2-4.23.84.24.14.03.53.52.6
Bone: final moment10.516.920.44.5-4.4-4.4-4.34.34.54.3-4.33.94.34.24.13.53.52.6
Food consumed during 24 hour testing period1.21.73.21.8-1.4-1.5-1.31.41.81.3-1.31.41.41.21.10.70.70.5
Glucose0.40.62.60.4-0.6-0.4-0.60.70.40.7-0.70.90.70.70.90.90.81.6
Heart weight0.10.10.50.4-0.3-0.3-0.30.30.50.3-0.30.70.30.30.30.10.10.2
Delay discount hyperbolic model param0.60.71.4-1.10.90.80.8-0.8-1.2-0.91.0-1.0-0.9-0.8-0.6-0.5-0.50.2
Intermittent access intake day 1-15 change0.00.10.4-0.00.20.30.3-0.30.10.10.00.20.1-0.3-0.2-0.3-0.2-0.7
Intermittent access intake escalation0.00.10.30.2-0.00.00.1-0.10.30.3-0.20.30.3-0.1-0.0-0.2-0.0-0.5
Intermittent access intake escalation 20.10.10.5-0.10.30.40.4-0.3-0.00.00.1-0.10.0-0.4-0.3-0.5-0.3-0.7
Intermitt. access day 1 inactive lever presses0.41.53.4-1.81.21.11.0-1.4-1.8-1.41.4-1.2-1.4-0.9-0.8-0.5-0.60.7
Intermitt. access day 15 inactive lever presses0.71.42.2-1.31.21.21.2-1.2-1.3-1.31.3-0.9-1.5-1.2-1.3-1.0-1.2-0.6
Intermitt. access escalation Index0.50.71.30.7-0.8-0.7-0.91.00.70.8-0.81.10.70.90.81.00.71.1
Intermittent access day 1 total infusions0.81.21.6-1.01.11.21.2-1.1-0.9-1.11.1-1.2-1.0-1.1-1.3-1.0-1.1-1.0
Intermittent access day 15 total infusions0.50.71.2-0.90.91.11.0-0.9-0.8-0.70.8-0.7-0.6-0.9-0.9-0.7-0.6-0.7
Intermittent access terminal intake (last 3 days)0.91.21.5-1.11.21.21.2-1.2-1.1-1.01.0-1.1-0.9-1.2-1.1-1.1-1.0-1.0
Intermittent access total infusions1.31.52.3-1.31.31.51.4-1.2-1.2-1.21.1-1.3-1.0-1.3-1.3-1.0-1.0-1.0
Intermittent access day 1 locomotion0.10.10.4-0.60.30.40.2-0.4-0.6-0.40.2-0.3-0.3-0.2-0.10.10.10.6
Intermittent access day 15 total locomotion0.10.20.6-0.80.40.40.3-0.5-0.8-0.30.1-0.1-0.1-0.20.00.20.40.7
Intermittent access total locomotion0.91.02.4-1.61.21.21.1-1.2-1.6-1.10.9-1.0-0.9-0.9-0.7-0.5-0.30.1
Intermittent access standard deviation0.20.30.7-0.40.60.80.6-0.5-0.3-0.30.5-0.4-0.3-0.6-0.7-0.6-0.6-0.8
Left kidney weight0.83.88.12.7-2.1-1.9-1.92.22.82.2-2.31.62.21.71.61.01.1-0.4
Right kidney weight4.118.721.94.6-4.5-4.4-4.44.54.74.7-4.64.24.64.44.33.94.02.5
Cocaine induced anxiety3.04.35.41.9-2.1-1.9-2.12.21.82.1-2.02.32.12.12.02.22.02.0
Post-drug Anxiety3.13.44.61.9-1.9-1.9-1.92.01.91.8-1.92.21.81.91.81.71.51.3
Baseline Anxiety0.00.00.20.3-0.1-0.1-0.10.20.40.0-0.3-0.10.10.10.1-0.1-0.1-0.4
Tail length0.00.10.20.1-0.2-0.1-0.20.40.20.3-0.10.50.20.20.10.40.30.5
Length with tail1.77.59.02.8-2.8-2.5-2.83.02.82.9-2.82.72.92.82.72.62.62.1
Length without tail5.417.524.04.8-4.4-4.1-4.34.54.94.5-4.54.04.64.14.13.43.52.2
Times rat made contact with spout0.10.10.20.10.10.40.2-0.10.2-0.0-0.1-0.3-0.0-0.2-0.1-0.4-0.3-0.4
Lifetime Intake1.51.83.0-1.51.51.71.5-1.3-1.4-1.31.2-1.4-1.1-1.4-1.4-1.1-1.1-1.1
Liver weight, left9.916.417.84.2-4.2-4.0-4.14.14.24.2-4.14.24.24.14.13.83.83.3
Liver weight, right2.44.25.22.1-2.1-2.3-2.12.02.02.0-2.12.02.02.12.31.81.81.9
Locomotor activity0.91.42.3-1.51.31.41.3-1.1-1.5-1.01.3-1.3-1.2-1.2-1.0-0.8-0.9-0.3
Locomotor testing distance2.23.95.9-2.42.22.22.1-2.1-2.4-1.92.0-2.1-2.0-2.0-1.7-1.5-1.5-0.7
Locomotor testing rearing1.63.25.3-2.32.02.01.9-1.9-2.3-1.92.0-1.6-1.9-1.8-1.4-1.2-1.30.0
Locomotion in novel chamber1.41.92.91.2-1.3-1.2-1.41.31.21.3-1.41.21.31.41.71.41.41.6
Locomotion in novel chamber post-restriction0.00.00.1-0.10.10.10.1-0.3-0.1-0.1-0.4-0.30.1-0.10.4-0.10.2-0.1
Fecal boli incidents, locomotor time 11.72.47.4-0.71.41.61.5-1.0-0.7-1.00.9-1.9-1.0-1.6-1.7-2.0-1.8-2.7
Change in fecal boli incidents, locomotor task0.70.61.10.6-0.8-1.0-0.90.80.60.8-0.50.80.70.90.81.10.90.8
Time >=10cm from walls, locomotor time 10.10.10.40.5-0.3-0.3-0.20.40.60.4-0.60.30.50.20.2-0.10.1-0.5
Bouts of movement, locomotor time 10.10.10.50.3-0.1-0.1-0.10.30.20.5-0.6-0.40.60.00.3-0.10.2-0.7
Total resting periods, locomotor time 10.20.31.3-0.20.40.40.5-0.2-0.30.0-0.1-1.00.0-0.5-0.3-0.6-0.4-1.2
Rest time, locomotor task time 10.30.31.6-0.20.40.60.5-0.2-0.2-0.20.0-1.0-0.0-0.5-0.4-0.7-0.5-1.3
Distance moved, locomotor task time 10.10.10.5-0.2-0.0-0.2-0.1-0.1-0.1-0.20.50.7-0.40.0-0.10.2-0.10.7
Vertical activity count, locomotor time 10.61.43.01.5-1.3-1.2-1.21.11.61.2-1.11.71.21.10.90.80.90.6
Time >=10cm from walls, locomotor time 20.40.61.2-0.80.80.90.8-0.7-0.7-0.60.6-1.1-0.7-0.8-0.8-0.7-0.6-0.9
Bouts of movement, locomotor time 22.33.64.81.6-1.9-1.9-1.91.61.52.1-2.01.82.12.02.12.02.21.7
Total resting periods, locomotor time 22.34.05.31.6-2.0-2.0-2.01.71.62.2-2.12.02.22.12.22.12.31.9
Rest time, locomotor task time 20.10.10.40.3-0.20.0-0.20.30.30.5-0.70.00.60.20.40.00.3-0.2
Distance moved, locomotor task time 20.20.20.6-0.50.40.20.4-0.5-0.4-0.60.7-0.2-0.8-0.4-0.5-0.3-0.6-0.2
Vertical activity count, locomotor time 20.10.10.30.2-0.3-0.2-0.30.30.20.1-0.30.60.20.30.30.40.40.5
Light reinforcement 11.94.68.8-2.82.42.42.2-2.2-3.0-2.22.3-1.9-2.2-2.1-2.0-1.4-1.3-0.5
Light reinforcement 20.60.91.4-1.11.01.11.0-0.7-1.2-0.81.0-0.9-0.9-1.0-1.1-0.6-0.7-0.9
Bone: marrow area7.215.717.83.9-4.1-4.2-4.14.13.73.9-3.94.13.94.14.13.83.73.6
Bone: maximum diameter4.68.610.32.8-3.0-2.6-3.03.22.73.1-3.13.13.13.02.92.92.92.7
Bone: maximum force14.225.129.45.2-5.3-5.4-5.35.15.15.1-5.15.05.15.25.14.64.53.9
Bone: maximum moment14.625.631.35.4-5.4-5.6-5.35.15.35.1-5.15.05.15.25.24.54.53.8
Mean time between licks in bursts0.10.40.6-0.60.60.30.5-0.7-0.5-0.70.7-0.6-0.6-0.6-0.6-0.6-0.6-0.8
Mean num. licks in bursts0.30.42.70.60.1-0.10.2-0.10.6-0.10.1-0.7-0.1-0.4-0.5-1.0-1.0-1.6
Cd content in liver0.80.81.4-0.60.91.01.0-0.8-0.6-0.90.8-0.9-0.9-1.0-0.9-1.2-1.2-0.9
Co content in liver0.10.10.4-0.20.20.60.20.1-0.20.1-0.20.10.2-0.1-0.20.10.2-0.6
Cu content in liver1.51.82.51.6-1.4-1.1-1.31.51.61.6-1.60.91.61.31.31.21.20.2
Fe content in liver1.51.82.9-1.31.41.71.4-1.2-1.3-1.31.3-1.3-1.3-1.4-1.5-1.2-1.2-1.4
K content in liver0.20.20.30.4-0.30.1-0.30.50.50.5-0.50.20.50.30.50.40.50.5
Mg content in liver0.10.10.4-0.10.20.30.3-0.1-0.1-0.10.2-0.5-0.1-0.3-0.4-0.3-0.3-0.7
Mn content in liver0.10.10.2-0.40.2-0.10.1-0.4-0.5-0.20.2-0.4-0.2-0.00.00.10.2-0.1
Na content in liver0.10.10.6-0.30.00.3-0.00.1-0.20.0-0.00.10.10.10.20.40.40.8
Rb content in liver0.10.10.30.1-0.10.3-0.10.30.20.5-0.40.30.40.20.10.40.4-0.5
Se content in liver1.21.41.9-1.21.31.41.3-1.2-1.1-1.21.1-1.2-1.1-1.3-1.2-1.2-1.1-1.1
Sr content in liver1.91.72.01.2-1.3-1.2-1.31.31.01.3-1.41.11.31.31.41.31.41.4
Zn content in liver0.60.71.2-0.90.91.10.9-0.7-1.0-0.80.8-1.0-0.8-0.8-0.6-0.6-0.70.2
Bone: minimum diameter9.517.318.64.1-4.3-4.2-4.34.33.94.2-4.24.24.24.34.34.04.03.7
Time in familiar zone, hab. session 10.40.41.2-0.30.50.50.6-0.5-0.2-0.60.6-0.7-0.6-0.6-0.7-0.8-0.8-1.1
Time in novel zone, hab. session 10.50.51.60.1-0.5-0.5-0.60.50.10.5-0.60.70.50.70.81.01.11.3
Total zone transitions, hab. session 10.30.40.6-0.70.70.70.6-0.6-0.7-0.60.6-0.6-0.6-0.6-0.7-0.4-0.4-0.6
Total locomotion distance, hab. session 10.00.00.20.1-0.0-0.30.0-0.00.1-0.10.1-0.2-0.1-0.0-0.1-0.1-0.2-0.4
Locomotion velocity, hab. session 10.00.00.10.1-0.1-0.4-0.10.00.10.0-0.0-0.1-0.00.10.1-0.0-0.1-0.1
Time in familiar zone, hab. session 20.20.20.60.7-0.5-0.5-0.40.40.80.4-0.40.30.40.30.1-0.0-0.0-0.5
Time in novel zone, hab. session 20.30.31.2-0.90.50.50.3-0.4-1.0-0.50.4-0.2-0.4-0.20.00.30.31.1
Total zone transitions, hab. session 20.30.41.5-0.30.60.60.6-0.5-0.3-0.40.4-0.8-0.5-0.6-0.7-0.7-0.8-1.2
Total locomotion distance, hab. session 20.20.21.0-0.10.40.00.4-0.4-0.1-0.40.4-0.7-0.4-0.5-0.4-0.6-0.7-1.0
Locomotion velocity, hab. session 20.10.10.90.10.2-0.10.2-0.20.1-0.20.2-0.5-0.2-0.3-0.3-0.5-0.6-0.9
Novel to familiar place preference ratio2.32.55.51.0-1.4-1.4-1.51.41.11.5-1.41.91.41.61.91.81.82.3
Novelty place preference1.81.95.10.8-1.2-1.1-1.31.10.81.2-1.11.71.21.41.71.61.62.3
Time in novel zone, NPP test1.61.75.50.6-1.1-1.0-1.21.00.61.1-1.01.61.01.31.61.61.62.4
Total zone transitions, NPP test1.31.94.5-1.01.31.41.4-1.1-1.0-1.21.1-1.6-1.1-1.4-1.5-1.4-1.5-2.1
Total locomotion distance, NPP test1.82.53.5-1.31.61.31.6-1.5-1.3-1.61.5-1.9-1.5-1.6-1.6-1.7-1.7-1.9
Locomotion velocity, NPP test1.01.42.9-0.81.10.91.2-1.0-0.9-1.11.1-1.5-1.1-1.2-1.2-1.3-1.4-1.7
Intraocular pressure6.99.911.8-3.43.33.03.2-3.2-3.4-3.43.3-3.3-3.3-3.1-3.2-2.9-2.8-2.3
Delta distance traveled before/after self-admin0.10.10.40.4-0.0-0.20.1-0.00.5-0.2-0.1-0.00.0-0.20.0-0.6-0.5-0.4
Delta ambulatory time before/after self-admin0.00.00.10.10.10.10.2-0.20.2-0.20.0-0.0-0.1-0.2-0.0-0.4-0.3-0.1
Parametrial fat weight0.71.62.5-1.31.41.61.4-1.2-1.3-1.21.1-1.2-1.1-1.4-1.1-1.3-1.2-1.0
Pavlov. Cond. lever latency0.00.00.2-0.1-0.1-0.5-0.2-0.2-0.0-0.20.20.0-0.20.10.30.10.10.4
Pavlov. Cond. magazine entry latency0.10.10.50.10.20.20.3-0.20.1-0.10.1-0.2-0.2-0.3-0.5-0.5-0.5-0.7
Pavlov. Cond. change in total contacts0.10.10.20.3-0.30.0-0.20.40.40.4-0.40.40.40.30.20.40.20.3
Pavlov. Cond. index score0.10.20.40.4-0.30.0-0.30.50.40.6-0.60.40.60.30.10.40.40.1
Pavlov. Cond. latency score0.10.10.30.4-0.30.1-0.20.50.40.6-0.50.40.50.20.10.30.3-0.1
Pavlov. Cond. lever contacts0.20.20.8-0.40.50.90.6-0.3-0.4-0.20.3-0.3-0.3-0.5-0.7-0.4-0.4-0.4
Pavlov. Cond. magazine entry number0.00.00.1-0.20.0-0.1-0.0-0.1-0.2-0.10.2-0.0-0.10.10.20.10.20.3
Pavlov. Cond. intertrial magazine entries0.40.51.3-0.50.70.60.7-0.7-0.4-0.70.7-1.1-0.7-0.7-0.5-0.8-0.8-1.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.7-0.6-0.2-0.50.80.70.9-0.80.60.80.50.40.60.60.2
Pavlov. Cond. response bias0.10.10.5-0.10.30.50.4-0.2-0.0-0.20.2-0.3-0.2-0.4-0.6-0.4-0.5-0.7
Pavlov. Cond. lever latency0.00.10.20.1-0.3-0.3-0.30.20.10.2-0.20.10.20.30.30.40.30.2
Pavlov. Cond. magazine entry latency0.91.11.41.1-1.1-1.1-1.11.01.11.0-0.91.21.01.11.00.90.81.1
Pavlov. Cond. change in total contacts1.72.73.51.8-1.7-1.5-1.61.91.91.8-1.71.91.81.61.61.31.31.3
Pavlov. Cond. index score0.70.91.31.1-1.0-0.9-1.01.01.11.0-1.01.11.00.91.00.80.80.9
Pavlov. Cond. latency score0.60.81.01.0-0.9-0.8-0.90.91.00.9-0.91.00.90.90.90.70.70.8
Pavlov. Cond. lever contacts0.00.00.10.10.10.20.1-0.00.10.0-0.00.00.1-0.1-0.1-0.2-0.2-0.1
Pavlov. Cond. magazine entry number2.63.23.6-1.71.81.71.8-1.8-1.7-1.81.7-1.9-1.8-1.8-1.9-1.7-1.7-1.9
Pavlov. Cond. intertrial magazine entries5.78.510.2-2.73.03.03.0-2.9-2.7-2.92.8-3.2-2.9-3.0-3.0-2.9-2.9-2.9
Pavlov. Cond. lever-magazine prob. diff.1.01.31.71.2-1.2-1.1-1.11.21.21.1-1.11.31.11.11.10.91.01.1
Pavlov. Cond. response bias0.10.10.20.4-0.3-0.2-0.30.40.40.3-0.30.40.40.30.30.20.20.3
Time in closed arm before self-admin2.32.94.11.5-1.8-1.7-1.81.81.41.7-1.52.01.61.81.62.01.91.6
Time in closed arm after self-admin0.10.10.30.3-0.3-0.4-0.30.20.20.2-0.10.60.20.30.10.40.3-0.1
Time in open arm before self-admin0.00.00.1-0.30.20.10.1-0.2-0.3-0.00.1-0.3-0.0-0.1-0.1-0.00.10.0
Time in open arm after self-admin0.10.10.5-0.30.10.20.1-0.1-0.3-0.1-0.0-0.4-0.1-0.00.3-0.00.10.7
Bone: periosteal estimation12.827.029.95.2-5.4-5.2-5.45.55.15.3-5.35.35.35.35.34.94.94.4
Bone: periosteal perimeter10.718.421.44.6-4.5-4.3-4.44.64.54.5-4.54.34.54.44.23.83.83.0
Bone: post-yield work7.911.614.13.2-3.5-3.7-3.63.43.13.3-3.33.73.33.63.43.53.43.0
Progressive ratio test 1 active lever presses4.04.97.8-2.72.52.62.4-2.3-2.8-2.22.1-2.3-2.1-2.2-2.0-1.7-1.6-0.9
Progressive ratio test 1 breakpoint3.64.47.2-2.62.32.52.3-2.2-2.7-2.12.0-2.2-2.0-2.1-1.9-1.5-1.5-0.8
Progressive ratio test 1 inactive lever presses1.52.23.5-1.91.61.81.6-1.5-1.9-1.61.4-1.5-1.5-1.5-1.4-1.0-1.0-0.5
Progressive ratio test 2 active lever presses1.21.43.1-1.71.41.41.3-1.2-1.8-1.11.2-1.2-1.0-1.2-1.0-0.6-0.6-0.1
Progressive ratio test 2 breakpoint1.11.33.0-1.71.31.31.2-1.1-1.7-1.01.1-1.1-1.0-1.1-1.0-0.6-0.5-0.1
Progressive ratio test 2 inactive lever presses0.81.42.6-1.61.31.31.3-1.1-1.6-1.11.2-1.2-1.1-1.1-1.1-0.7-0.7-0.2
Incentive Sensitization - Responses0.30.40.60.4-0.5-0.6-0.50.70.30.8-0.50.60.70.60.60.80.80.6
Incentive Sensitization - Breakpoint0.20.30.50.3-0.4-0.5-0.40.50.20.7-0.40.50.60.50.50.70.70.5
Sum of active levers in priming session hrs 5-60.00.00.10.0-0.0-0.1-0.0-0.10.1-0.20.2-0.0-0.20.0-0.2-0.2-0.2-0.2
Progressive ratio0.20.30.6-0.30.50.40.6-0.5-0.3-0.60.5-0.4-0.6-0.6-0.7-0.8-0.8-0.5
Food seeking constrained by brief footshock0.50.71.2-0.80.91.10.9-0.6-0.8-0.90.4-0.7-0.7-0.8-1.0-0.6-0.7-1.0
Seeking ratio, punishment vs. effort0.00.00.1-0.20.10.20.00.0-0.2-0.1-0.2-0.10.00.0-0.10.30.2-0.3
Retroperitoneal fat weight0.31.22.3-0.91.11.21.1-1.1-0.9-0.90.8-1.5-0.8-1.2-0.9-1.2-0.9-1.5
Reaction time number correct0.71.32.71.2-1.3-1.6-1.31.21.01.1-0.90.71.01.21.21.11.00.9
Reaction time mean minus median4.611.414.7-2.93.43.43.5-3.4-2.7-3.23.5-3.2-3.3-3.5-3.7-3.5-3.8-3.3
Reaction time mean minus median AUC3.28.010.7-2.52.92.72.9-2.9-2.3-2.83.0-2.6-2.8-3.0-3.1-2.9-3.3-2.7
Reaction time num false alarms1.82.53.2-1.31.51.41.6-1.6-1.3-1.71.7-1.5-1.7-1.6-1.6-1.8-1.8-1.3
Reaction time num false alarms AUC2.43.85.4-1.51.91.71.9-2.0-1.4-2.12.1-1.8-2.1-2.0-2.1-2.3-2.3-1.7
Reaction time trials correct on left0.71.32.71.2-1.3-1.6-1.31.21.01.1-0.90.71.01.21.21.11.00.9
Reaction time trials on left0.50.92.11.0-1.1-1.5-1.11.10.90.9-0.80.50.81.01.01.00.90.7
Reaction time mean0.50.71.1-0.70.90.91.0-0.9-0.6-0.80.7-0.7-0.6-1.0-0.9-0.9-1.0-1.0
Reaction time mean AUC0.20.40.8-0.40.60.70.7-0.7-0.2-0.50.4-0.5-0.4-0.7-0.6-0.7-0.8-0.9
Median of all reaction times0.10.10.20.3-0.2-0.1-0.20.20.40.3-0.50.40.50.20.30.10.2-0.0
Reaction time omissions9.814.316.6-3.53.83.83.9-3.7-3.5-3.73.7-3.9-3.7-3.9-4.1-3.8-3.8-3.8
Reaction time false alarm rate2.63.64.9-1.61.92.02.0-2.0-1.5-2.01.9-1.6-2.0-2.0-2.0-2.2-2.2-1.6
Reaction time premature initiation rate4.25.98.2-2.82.72.92.6-2.3-2.7-2.52.5-2.2-2.5-2.5-2.4-2.1-2.2-1.0
Reaction time premature initiations1.73.04.3-2.01.91.81.8-1.6-2.1-1.81.9-1.7-1.9-1.8-1.6-1.4-1.5-0.5
Std. dev. reaction times4.78.710.6-2.63.03.03.1-3.0-2.4-2.92.9-2.8-2.8-3.1-3.2-3.1-3.3-2.9
Reaction time trials completed0.50.92.11.0-1.1-1.5-1.11.10.90.9-0.80.50.81.01.01.00.90.7
Reaction time trials AUC0.91.73.31.3-1.4-1.8-1.41.41.21.2-1.10.81.21.41.41.31.21.0
Run reversals in cocaine runway, females0.00.00.3-0.1-0.0-0.1-0.0-0.1-0.0-0.00.10.3-0.10.00.20.20.00.5
Run reversals in cocaine runway, males1.21.21.5-1.21.11.11.1-1.2-1.2-1.21.1-1.2-1.0-1.1-1.1-0.9-0.8-0.8
Latency to leave start box in cocaine runway0.00.00.1-0.20.20.20.2-0.2-0.3-0.30.20.1-0.1-0.1-0.1-0.3-0.00.1
Latency to leave start box in cocaine runway, F1.01.12.0-1.31.11.11.0-1.2-1.4-1.31.2-0.9-1.2-1.0-1.0-0.9-0.6-0.2
Latency to leave start box in cocaine runway, M1.71.62.31.5-1.3-1.3-1.31.21.51.3-1.31.41.31.21.40.80.90.9
Std. dev. time between licks in bursts0.60.81.5-1.21.01.01.0-1.0-1.2-1.00.9-0.7-1.0-0.9-0.8-0.6-0.6-0.3
Total sessions with >9 infusions1.21.52.6-1.31.41.61.4-1.1-1.3-1.10.9-1.3-0.9-1.3-1.3-1.1-1.0-1.2
Short access day 1 total inactive lever presses1.31.72.7-1.31.41.61.4-1.2-1.3-1.31.2-1.4-1.2-1.4-1.4-1.2-1.3-0.9
Short access day 10 total inactive lever presses0.10.20.4-0.60.50.50.4-0.5-0.6-0.50.6-0.5-0.5-0.4-0.4-0.2-0.30.2
Short access day 1 total infusions0.30.50.8-0.60.70.90.8-0.5-0.6-0.50.4-0.8-0.5-0.7-0.8-0.6-0.7-0.9
Short access day 10 total infusions0.91.12.3-1.11.21.51.2-0.9-1.0-0.90.9-1.0-0.8-1.1-1.1-0.9-0.8-0.9
Short access total infusions1.51.93.3-1.51.51.81.6-1.3-1.5-1.31.2-1.4-1.2-1.5-1.4-1.1-1.1-1.0
Short access day 1 locomotion0.10.10.3-0.50.30.50.3-0.2-0.5-0.2-0.0-0.1-0.1-0.2-0.10.00.10.5
Short access day 10 total locomotion0.20.41.2-1.10.60.60.4-0.6-1.1-0.70.4-0.4-0.4-0.3-0.10.10.20.9
Short access total locomotion0.60.71.8-1.30.91.10.8-0.9-1.4-0.90.6-0.6-0.7-0.7-0.5-0.3-0.10.4
One hour access (0.3 mA shock)0.00.00.2-0.10.20.40.3-0.2-0.10.10.10.00.1-0.2-0.3-0.0-0.1-0.3
Compulsive drug intake0.10.10.70.10.10.20.2-0.20.1-0.40.3-0.2-0.5-0.3-0.5-0.4-0.8-0.6
One hour access (shock baseline)0.10.10.60.2-0.2-0.0-0.10.30.20.5-0.40.40.80.20.30.40.70.1
Social response proportion0.10.20.4-0.20.30.50.4-0.0-0.2-0.40.5-0.2-0.4-0.4-0.6-0.3-0.5-0.4
Social responses6.98.911.2-3.23.13.23.1-2.9-3.1-3.23.3-2.6-3.2-3.0-3.3-2.6-2.7-2.0
Social time0.20.31.80.5-0.1-0.00.10.10.60.10.2-0.2-0.0-0.2-0.7-0.7-0.7-1.3
Soleus weight0.61.61.91.3-1.3-1.2-1.31.41.21.3-1.31.31.31.31.11.31.31.0
Bone: stiffness16.927.531.65.4-5.5-5.6-5.55.45.35.4-5.45.45.45.45.24.94.93.9
Tibialis anterior weight1.55.17.21.7-2.0-1.4-2.12.31.72.4-2.42.72.42.22.22.72.62.7
Time to tail flick, vehicle, before self-admin2.12.23.4-1.41.41.21.4-1.3-1.3-1.51.8-1.5-1.7-1.5-1.6-1.6-1.7-1.1
Time to tail flick, vehicle, after self-admin0.10.10.5-0.0-0.3-0.4-0.40.2-0.10.3-0.20.20.20.40.20.70.60.5
Time to tail flick, test, before self-admin0.50.52.4-0.50.60.40.6-0.8-0.4-0.60.5-0.9-0.6-0.6-0.6-0.7-0.6-1.5
Time to tail flick, test, after self-admin0.50.51.00.9-0.8-1.0-0.80.50.90.7-0.80.80.80.70.60.50.5-0.0
Delta time to tail flick, vehicle, before/after SA0.60.60.90.8-0.8-0.7-0.80.80.70.8-1.00.80.90.80.70.90.90.4
Delta time to tail flick, test, before/after SA0.30.30.70.6-0.5-0.5-0.50.60.50.4-0.60.70.60.50.50.40.50.8
Tibia length7.621.024.44.6-4.7-4.5-4.74.84.64.7-4.64.94.74.74.64.44.43.7
Ambulatory time before self-admin1.52.33.4-1.81.61.71.5-1.7-1.9-1.51.5-1.8-1.6-1.4-1.3-1.1-1.0-0.7
Ambulatory time after self-admin0.91.01.4-1.21.11.21.1-1.2-1.1-1.11.0-1.2-1.0-1.1-0.7-0.9-0.8-0.2
Bone: tissue strength0.70.71.30.8-0.9-1.1-1.00.70.80.7-0.70.80.70.90.80.80.80.7
Total heroin consumption1.21.43.60.5-1.0-0.9-1.10.70.61.1-1.01.01.01.21.61.61.61.9
Bone: trabecular number5.08.313.33.6-3.1-3.4-3.03.03.62.9-2.93.02.92.82.61.81.91.2
Bone: trabecular spacing1.82.44.9-2.21.71.91.6-1.6-2.2-1.51.6-1.7-1.5-1.4-1.2-0.7-0.7-0.0
Bone: trabecular thickness0.10.10.30.10.20.20.3-0.10.1-0.10.1-0.3-0.2-0.3-0.2-0.5-0.6-0.3
Bone: trabecular tissue density0.10.10.9-0.60.20.00.1-0.3-0.6-0.20.2-0.1-0.20.00.30.40.40.9
Water consumed over 24 hours0.10.10.20.4-0.3-0.4-0.30.30.40.2-0.30.10.20.20.40.10.10.4
Number of responses in last shaping day0.10.21.2-0.50.20.20.1-0.1-0.6-0.10.00.1-0.00.10.20.40.41.1