Hub : Genes

Fign

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Fign 0.39 0.17 1.4e-05 0.1 0.18 0.15 0.15 1.9e-03 5.3e-05 2.1e-04 2.6e-04
2 IL gene expression Fign 0.16 0.1 4.5e-03 0.08 0.08 0.05 0.06 6.9e-03 6.5e-03 2.8e-02 1.3e-02
3 Adipose gene expression Fign 0.12 0.06 8.5e-14 0.09 0.09 0.09 0.09 9.7e-10 4.8e-10 3.0e-10 1.7e-10
4 Brain gene expression Fign 0.03 0.02 2.0e-03 0.03 0.03 0.01 0.03 3.4e-04 7.6e-04 3.0e-02 3.8e-04
5 NAcc gene expression Fign 0.03 0.02 1.2e-03 0.02 0.02 0.02 0.02 1.3e-03 7.4e-04 1.8e-03 2.8e-03
6 Liver gene expression Fign 0.07 0.06 4.3e-06 0.05 0.03 0.04 0.04 6.4e-06 1.0e-04 3.0e-05 5.0e-05
7 Liver alternative TSS XM_008761889.3 0.04 0.03 6.2e-05 0.04 0.03 0.03 0.03 6.5e-05 1.4e-04 7.0e-04 2.1e-04
8 PL gene expression Fign 0.07 0.05 2.4e-04 0.02 0.04 0.04 0.04 3.4e-03 3.7e-05 2.0e-05 4.8e-05
9 OFC alternative TSS XM_008761889.3 0.13 0.09 9.6e-03 0.08 0.03 0.06 0.06 5.7e-03 5.8e-02 1.3e-02 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.20.70.40.30.20.1-0.4-0.70.60.30.8
Area under the delay curve0.20.20.4-0.3-0.4-0.2-0.70.30.6-0.20.5-0.4
BMI with tail0.62.15.5-1.0-1.4-1.4-0.81.80.5-2.3-0.7-1.9
BMI without tail0.00.10.2-0.4-0.3-0.5-0.40.20.2-0.20.40.1
Body weight0.41.87.71.40.60.51.8-0.0-1.6-0.4-2.8-0.3
Weight adjusted by age1.21.43.2-1.2-0.8-1.6-1.40.61.3-0.41.8-0.7
Bone surface1.01.83.01.41.31.41.0-1.4-1.31.7-0.31.6
Bone volume0.50.81.50.90.80.80.9-0.8-1.21.0-0.41.1
Breakpoint value in progressive ratio session1.41.62.5-1.4-1.4-1.2-1.21.21.6-1.00.9-1.4
Number of licking bursts0.10.10.3-0.3-0.30.1-0.50.20.5-0.10.6-0.1
Context. condit. distance diff. score0.10.10.30.60.40.50.2-0.4-0.20.5-0.20.2
Locomotion velocity, session 10.20.20.50.10.30.6-0.1-0.5-0.10.60.70.7
Locomotion distance, session 10.10.20.50.10.20.20.0-0.3-0.20.70.60.7
Locomotion velocity, session 21.21.43.2-1.2-1.0-1.2-1.50.71.4-0.31.8-0.6
Locomotion distance, session 20.71.01.81.11.00.51.1-0.9-1.11.3-0.60.9
Locomotion velocity, session 30.50.61.2-0.9-0.7-0.6-0.90.60.9-0.51.1-0.4
Locomotion distance, session 30.10.10.4-0.00.10.3-0.0-0.1-0.10.20.50.6
Stereotopy head waving bouts, day 30.91.03.21.20.70.71.3-0.4-1.20.5-1.80.1
Stereotopy head waving duration, day 30.60.71.41.10.80.81.2-0.6-0.70.9-1.00.2
Locomotion velocity, session 70.10.10.30.10.40.60.1-0.50.30.3-0.20.1
Locomotion distance, session 70.20.20.40.50.60.60.3-0.60.00.4-0.4-0.0
Stereotopy head waving bouts, day 70.20.20.50.50.30.20.6-0.2-0.60.7-0.10.6
Stereotopy head waving duration, day 70.40.51.00.60.50.61.0-0.4-1.00.8-0.40.8
Locomotion velocity, session 80.10.20.40.20.30.60.0-0.4-0.00.60.30.5
Locomotion distance, session 80.10.10.30.50.30.00.3-0.1-0.20.5-0.10.1
Degree of sensitization distance0.20.20.70.30.0-0.20.30.10.0-0.3-0.8-0.8
Degree of sensitization stereotypy0.30.40.7-0.6-0.8-0.8-0.10.8-0.0-0.40.80.1
Conditioned locomotion0.00.10.20.00.0-0.5-0.3-0.00.20.20.00.1
Cocaine response after cond. corrected4.45.08.1-2.1-2.2-2.2-2.32.32.2-2.70.6-2.8
Cocaine response after cond. not corrected1.31.54.6-0.7-1.0-1.0-0.91.21.2-1.4-0.6-2.1
Cocaine response before conditioning5.06.08.02.82.62.32.8-2.5-2.12.8-2.21.9
Saline control response0.40.51.0-0.5-0.9-0.7-0.61.00.2-0.90.6-0.3
Bone: connectivity density0.20.31.00.40.30.1-0.0-0.5-0.30.90.91.0
Bone: cortical apparent density0.10.10.30.10.10.10.4-0.2-0.30.30.50.6
Bone: cortical area3.75.67.22.72.42.42.6-2.1-2.72.0-2.51.9
Bone: cortical porosity1.92.13.71.41.31.41.7-1.1-1.91.0-1.61.5
Bone: cortical porosity3.43.75.52.01.91.82.1-1.7-2.31.6-1.72.0
Bone: cortical thickness1.52.45.51.61.11.22.0-0.9-2.30.9-1.71.4
Bone: cortical thickness3.33.97.62.11.61.72.2-1.3-2.81.4-2.12.0
Bone: cortical tissue density0.10.10.5-0.0-0.0-0.00.3-0.1-0.20.20.70.5
Condit. Reinf. active minus inactive responses3.94.49.31.91.71.82.1-1.6-3.01.5-1.43.0
Condit. Reinf. active-inactive response ratio1.11.13.20.80.70.71.2-0.5-1.80.3-0.91.7
Condit. Reinf. active responses4.35.27.82.32.42.42.1-2.4-2.42.3-1.22.8
Condit. Reinf. inactive responses2.63.15.51.82.22.21.3-2.3-0.92.0-1.01.1
Incentive salience index mean3.84.59.42.01.91.92.1-1.8-2.91.8-1.23.1
Condit. Reinf. lever presses0.50.71.20.90.90.70.8-0.8-0.90.7-0.41.1
Condit. Reinf. active minus inactive responses5.16.48.83.02.82.52.7-2.6-2.12.7-1.72.3
Condit. Reinf. active-inactive response ratio2.93.14.61.92.01.71.7-2.0-1.32.1-0.81.9
Condit. Reinf. active responses4.66.39.13.02.72.43.0-2.4-2.42.3-2.51.8
Condit. Reinf. inactive responses0.50.62.20.90.50.51.2-0.2-0.9-0.0-1.5-0.2
Condit. Reinf. lever presses5.16.99.33.02.82.73.0-2.7-2.32.7-2.12.2
Condit. Reinf. lever reinforcers received3.54.97.22.72.52.22.5-2.3-1.92.2-1.91.7
Conditioned reinforcement - actives1.01.01.31.10.90.91.1-0.8-1.11.0-1.10.7
Conditioned reinforcement - inactives0.30.40.90.50.60.40.4-0.60.50.5-0.9-0.8
Conditioned locomotion0.40.52.10.70.30.60.9-0.0-0.80.2-1.4-0.3
Patch foraging indifference point 0 sec0.20.41.0-0.4-0.8-0.3-0.10.9-0.8-1.0-0.5-0.0
Patch foraging indifference point AUC2.12.46.90.91.61.4-0.2-2.21.12.61.41.2
Delay disc. indifference point, 0s delay0.20.31.10.50.61.00.3-0.6-0.20.1-0.40.0
Delay disc. indifference point, 16s delay0.10.10.3-0.3-0.5-0.1-0.10.5-0.2-0.4-0.2-0.3
Delay disc. indifference point, 2s delay0.20.20.5-0.10.30.5-0.7-0.50.00.10.70.6
Delay disc. indifference point, 24s delay0.20.20.8-0.1-0.00.0-0.1-0.10.90.60.9-0.1
Delay disc. indifference point, 4s delay0.91.02.2-0.7-0.7-0.7-1.50.61.4-0.61.3-0.7
Delay disc. indifference point, 8s delay0.20.20.4-0.4-0.6-0.6-0.60.70.2-0.40.1-0.4
Indifference point function ln k0.50.72.0-0.4-0.7-0.6-0.11.0-0.8-1.4-1.0-0.4
Indifference point function log k0.50.72.0-0.4-0.7-0.6-0.11.0-0.8-1.4-1.0-0.4
Patch foraging total patch changes 0 sec0.50.92.1-0.9-1.3-0.8-0.61.4-0.3-1.4-0.1-0.4
Patch foraging total patch changes 12 sec1.11.42.01.21.31.31.1-1.3-1.01.4-0.51.3
Patch foraging total patch changes 18 sec1.31.62.21.01.31.41.1-1.4-1.31.5-0.71.5
Patch foraging total patch changes 24 sec1.61.93.31.51.21.41.3-1.1-1.81.5-0.81.6
Patch foraging total patch changes 6 sec0.20.30.5-0.7-0.6-0.4-0.70.50.6-0.40.6-0.2
Patch foraging time to switch 0 sec0.81.33.1-0.5-1.0-0.60.31.4-0.3-1.8-1.5-1.6
Patch foraging water rate 0 sec2.03.24.02.01.91.61.6-1.8-1.92.0-1.12.0
Patch foraging water rate 12 sec1.42.22.81.61.71.41.6-1.6-1.61.3-0.81.4
Patch foraging water rate 18 sec2.73.75.02.12.01.52.0-2.0-2.22.1-0.52.2
Patch foraging water rate 24 sec0.91.22.31.01.11.00.7-1.3-1.01.40.61.5
Patch foraging water rate 6 sec1.62.43.01.71.71.51.4-1.6-1.61.6-1.01.5
Seeking ratio, delayed vs. immediate footshock0.50.61.30.70.60.51.1-0.5-0.90.4-1.10.4
Distance traveled before self-admin6.46.810.52.72.43.03.2-2.1-2.81.9-3.21.6
Distance traveled after self-admin3.84.35.42.02.22.22.0-2.2-2.11.7-2.31.8
Extensor digitorum longus weight0.41.72.71.41.41.61.6-1.4-1.10.9-1.50.4
Bone: elastic displacement1.31.52.7-1.2-1.4-1.6-0.61.60.6-1.70.6-0.9
Bone: elastic work0.40.51.1-0.5-0.8-0.8-0.20.90.5-1.00.4-0.6
Bone: endosteal estimation1.22.74.51.62.02.01.3-2.1-0.82.1-0.81.3
Bone: endosteal perimeter2.65.48.92.52.92.81.6-3.0-1.32.7-1.32.0
Epididymis fat weight10.123.629.0-5.1-5.3-5.4-4.55.24.6-5.03.5-4.9
Delta time in closed arm before/after self-admin0.30.30.7-0.3-0.6-0.6-0.20.80.1-0.8-0.2-0.5
Delta time in open arm before/after self-admin0.40.30.80.40.60.60.5-0.6-0.90.3-0.30.8
Diff in mean of infusions in LGA sessions10.011.115.0-3.7-3.9-3.7-3.53.82.7-3.42.7-2.4
Delay discount exponential model param0.30.30.70.50.50.40.8-0.4-0.80.3-0.80.5
Extinction: sum of active levers before priming0.80.82.00.80.80.91.1-0.7-1.10.4-1.40.4
Active lever presses in extinction session 60.80.83.80.3-0.1-0.20.60.5-1.4-0.7-2.0-0.1
Bone: final force3.15.07.22.22.42.71.9-2.5-2.12.4-1.32.4
Bone: final moment2.74.46.52.12.32.61.8-2.3-2.12.1-1.22.3
Food consumed during 24 hour testing period1.01.31.91.21.00.91.4-0.9-1.40.9-1.11.1
Glucose0.50.81.50.60.71.00.9-0.6-1.20.4-1.11.0
Heart weight0.20.20.80.30.10.00.70.1-0.3-0.6-0.9-0.7
Delay discount hyperbolic model param0.30.30.80.50.40.20.9-0.3-0.80.2-0.90.4
Intermittent access intake day 1-15 change4.04.06.12.12.42.51.7-2.5-1.61.9-1.51.4
Intermittent access intake escalation3.63.55.42.02.32.31.7-2.3-1.51.8-1.41.3
Intermittent access intake escalation 21.61.52.51.11.51.40.9-1.6-1.31.1-0.21.5
Intermitt. access day 1 inactive lever presses0.60.72.6-0.0-0.2-0.5-0.20.50.9-0.9-1.1-1.6
Intermitt. access day 15 inactive lever presses0.30.31.00.70.70.40.5-0.60.30.5-1.0-0.1
Intermitt. access escalation Index0.40.31.1-0.3-0.4-0.4-0.40.5-1.0-0.5-0.01.0
Intermittent access day 1 total infusions0.10.20.70.0-0.2-0.10.40.4-0.3-0.2-0.9-0.5
Intermittent access day 15 total infusions2.02.23.01.51.51.71.6-1.4-1.71.3-1.70.8
Intermittent access terminal intake (last 3 days)2.12.34.21.61.41.61.4-1.3-2.01.4-1.01.7
Intermittent access total infusions1.01.12.21.10.91.01.1-0.8-1.50.9-1.10.8
Intermittent access day 1 locomotion0.70.72.0-0.3-0.7-0.30.21.0-0.1-0.9-1.3-1.4
Intermittent access day 15 total locomotion2.02.24.51.51.51.91.6-1.4-1.31.0-2.10.4
Intermittent access total locomotion0.40.52.60.70.40.70.5-0.1-0.6-0.1-1.6-0.3
Intermittent access standard deviation3.43.65.11.92.12.32.1-2.1-1.91.6-1.90.9
Left kidney weight1.95.410.93.02.52.42.7-2.0-1.91.3-3.30.6
Right kidney weight1.43.98.32.62.22.22.1-1.8-1.50.8-2.90.2
Cocaine induced anxiety2.52.94.9-1.8-2.1-2.0-1.92.20.8-1.81.3-0.5
Post-drug Anxiety0.40.51.0-0.5-0.8-0.7-0.41.00.5-0.8-0.3-0.8
Baseline Anxiety1.51.64.81.21.31.41.4-1.1-0.50.5-2.2-0.5
Tail length2.47.111.62.62.92.62.4-3.1-2.13.4-1.43.0
Length with tail1.55.58.42.72.32.32.6-2.0-2.51.9-2.91.7
Length without tail1.32.99.82.01.21.42.1-0.6-1.90.3-3.1-0.0
Times rat made contact with spout2.22.54.3-1.5-1.8-2.1-1.01.91.4-1.61.0-1.7
Lifetime Intake1.41.63.61.20.91.11.4-0.7-1.90.9-1.61.0
Liver weight, left0.10.20.50.40.40.50.3-0.30.10.1-0.7-0.5
Liver weight, right0.61.04.71.11.00.60.8-0.7-0.20.1-2.2-0.9
Locomotor activity3.04.86.42.42.32.52.4-2.2-2.12.3-1.41.9
Locomotor testing distance5.49.113.03.13.13.63.1-3.0-3.12.7-2.32.8
Locomotor testing rearing6.710.412.43.33.53.53.2-3.4-3.23.0-2.82.9
Locomotion in novel chamber0.30.30.8-0.4-0.8-0.5-0.00.90.1-0.7-0.4-0.8
Locomotion in novel chamber post-restriction0.10.20.40.2-0.3-0.30.60.5-0.6-0.1-0.5-0.1
Fecal boli incidents, locomotor time 10.80.93.0-1.0-0.8-0.5-1.40.50.9-0.41.7-0.4
Change in fecal boli incidents, locomotor task1.81.74.31.31.21.42.1-1.0-1.11.2-1.30.4
Time >=10cm from walls, locomotor time 10.40.41.00.60.50.81.0-0.4-0.60.4-0.50.6
Bouts of movement, locomotor time 16.67.210.2-2.8-3.2-2.7-2.63.12.2-2.62.6-2.0
Total resting periods, locomotor time 16.37.010.0-2.8-3.2-2.7-2.63.12.1-2.52.6-1.9
Rest time, locomotor task time 13.53.84.5-2.1-2.1-2.1-2.02.01.9-1.72.0-1.5
Distance moved, locomotor task time 13.84.27.32.22.22.12.1-2.0-2.01.4-2.71.4
Vertical activity count, locomotor time 10.50.50.90.60.80.90.6-0.7-0.80.3-0.80.5
Time >=10cm from walls, locomotor time 21.61.72.41.51.51.51.5-1.4-1.00.9-1.40.5
Bouts of movement, locomotor time 25.86.310.0-2.9-3.1-2.4-2.43.21.6-3.11.3-2.0
Total resting periods, locomotor time 27.58.012.3-3.3-3.5-2.7-2.73.51.9-3.31.7-2.2
Rest time, locomotor task time 22.52.83.4-1.8-1.9-1.8-1.91.81.5-1.51.5-1.4
Distance moved, locomotor task time 22.73.15.12.12.01.81.6-1.8-1.71.1-2.31.1
Vertical activity count, locomotor time 20.00.10.2-0.10.20.1-0.5-0.3-0.0-0.3-0.10.1
Light reinforcement 10.10.20.70.20.20.00.1-0.2-0.50.50.50.8
Light reinforcement 20.91.25.5-0.4-0.1-0.4-1.0-0.10.10.72.31.9
Bone: marrow area1.32.84.61.72.02.11.3-2.2-0.92.1-0.71.3
Bone: maximum diameter2.64.96.52.52.42.32.4-2.2-2.12.2-2.11.6
Bone: maximum force3.15.47.62.52.62.82.0-2.6-2.12.3-1.72.2
Bone: maximum moment2.95.07.22.42.52.72.0-2.5-2.02.1-1.72.1
Mean time between licks in bursts0.81.12.11.31.51.40.5-1.4-0.21.1-0.90.3
Mean num. licks in bursts0.40.51.5-0.6-0.7-1.2-0.10.80.3-0.8-0.1-0.8
Cd content in liver1.31.42.8-1.2-1.0-1.1-1.70.91.5-1.11.1-1.1
Co content in liver0.91.13.41.20.90.41.4-0.7-0.90.8-1.90.2
Cu content in liver0.40.51.20.40.70.60.4-0.8-0.31.00.51.1
Fe content in liver2.12.53.1-1.8-1.7-1.4-1.81.61.5-1.61.7-1.1
K content in liver2.02.03.51.41.81.50.7-1.9-0.71.8-0.71.5
Mg content in liver2.02.03.11.51.71.50.9-1.8-1.11.6-1.11.5
Mn content in liver6.77.613.42.72.92.92.2-3.0-2.63.0-1.03.7
Na content in liver4.54.76.62.62.52.41.9-2.3-1.82.3-1.72.0
Rb content in liver1.11.42.11.41.31.11.3-1.2-0.81.4-1.30.5
Se content in liver0.40.50.9-0.8-0.9-0.5-0.70.90.4-0.90.6-0.4
Sr content in liver1.21.11.71.21.00.81.3-0.9-1.30.8-1.01.0
Zn content in liver0.20.20.4-0.1-0.5-0.60.20.60.1-0.2-0.4-0.5
Bone: minimum diameter1.42.64.01.81.92.01.6-1.8-1.21.6-1.51.0
Time in familiar zone, hab. session 10.80.71.90.71.01.20.4-1.10.21.40.10.5
Time in novel zone, hab. session 11.51.53.1-1.2-1.4-1.4-1.01.50.7-1.80.4-1.2
Total zone transitions, hab. session 12.02.84.22.11.71.41.6-1.6-1.71.9-0.81.9
Total locomotion distance, hab. session 12.43.55.52.22.22.01.0-2.2-1.32.3-0.52.0
Locomotion velocity, hab. session 12.02.84.41.92.01.80.9-2.0-1.22.1-0.51.8
Time in familiar zone, hab. session 21.41.42.3-1.0-1.2-1.3-1.01.11.5-0.81.1-1.5
Time in novel zone, hab. session 21.01.02.30.70.71.01.2-0.7-1.50.4-1.21.0
Total zone transitions, hab. session 21.41.82.71.61.20.91.6-1.0-1.61.5-1.01.2
Total locomotion distance, hab. session 20.30.50.90.70.50.70.4-0.5-0.90.8-0.20.9
Locomotion velocity, hab. session 20.30.40.70.70.60.80.3-0.6-0.70.9-0.20.8
Novel to familiar place preference ratio0.70.71.8-0.3-0.9-0.7-0.31.20.2-1.3-0.5-1.3
Novelty place preference0.90.92.0-0.5-1.0-0.8-0.31.40.2-1.4-0.3-1.4
Time in novel zone, NPP test0.90.92.1-0.5-1.0-0.8-0.31.30.2-1.4-0.3-1.5
Total zone transitions, NPP test0.30.41.20.90.60.30.7-0.6-0.51.10.20.6
Total locomotion distance, NPP test0.81.22.81.31.21.10.5-1.2-0.71.70.11.2
Locomotion velocity, NPP test0.91.32.81.31.31.20.5-1.3-0.71.7-0.21.3
Intraocular pressure1.01.32.61.21.11.01.4-1.1-1.61.0-0.61.1
Delta distance traveled before/after self-admin0.70.71.8-1.0-0.5-1.1-1.30.31.1-0.50.7-0.5
Delta ambulatory time before/after self-admin0.10.10.40.10.5-0.1-0.3-0.60.00.5-0.20.4
Parametrial fat weight4.18.112.2-3.1-2.8-2.8-2.82.53.5-2.62.3-3.1
Pavlov. Cond. lever latency0.40.51.1-0.9-0.4-0.1-1.00.21.1-0.50.8-0.6
Pavlov. Cond. magazine entry latency0.20.20.70.2-0.0-0.20.70.1-0.2-0.3-0.9-0.6
Pavlov. Cond. change in total contacts0.60.70.90.90.80.40.9-0.8-0.80.9-0.70.8
Pavlov. Cond. index score0.50.61.21.00.70.31.1-0.5-0.80.6-1.10.3
Pavlov. Cond. latency score0.50.71.51.00.70.21.2-0.4-0.90.6-1.10.4
Pavlov. Cond. lever contacts0.70.91.81.10.70.21.4-0.4-1.30.7-1.00.8
Pavlov. Cond. magazine entry number0.10.10.3-0.3-0.4-0.2-0.50.50.1-0.40.2-0.3
Pavlov. Cond. intertrial magazine entries2.32.83.81.81.91.81.3-1.9-1.41.7-1.61.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.51.00.70.31.1-0.5-0.90.5-1.20.3
Pavlov. Cond. response bias0.10.10.40.40.30.20.6-0.3-0.40.2-0.60.2
Pavlov. Cond. lever latency5.06.811.7-2.8-2.5-2.6-3.42.42.7-2.42.4-2.0
Pavlov. Cond. magazine entry latency0.40.51.60.5-0.1-0.51.30.4-0.6-0.0-1.1-0.5
Pavlov. Cond. change in total contacts2.33.24.92.01.91.92.2-1.9-1.32.2-1.01.3
Pavlov. Cond. index score1.51.94.91.61.10.92.2-0.9-1.51.1-1.70.5
Pavlov. Cond. latency score1.11.43.81.40.90.62.0-0.7-1.31.0-1.50.4
Pavlov. Cond. lever contacts3.95.39.72.62.22.23.1-2.0-2.52.1-2.01.7
Pavlov. Cond. magazine entry number0.30.31.3-0.5-0.10.3-1.1-0.10.3-0.30.80.5
Pavlov. Cond. intertrial magazine entries0.70.91.40.91.21.20.4-1.1-0.80.8-0.91.0
Pavlov. Cond. lever-magazine prob. diff.1.21.54.01.41.00.82.0-0.8-1.31.0-1.50.4
Pavlov. Cond. response bias2.83.88.82.21.71.63.0-1.5-2.01.6-2.01.0
Time in closed arm before self-admin0.30.30.9-0.5-0.3-0.2-0.60.11.0-0.30.8-0.4
Time in closed arm after self-admin0.10.10.20.40.40.30.3-0.30.00.2-0.20.1
Time in open arm before self-admin0.50.51.0-0.6-0.8-1.0-0.50.61.00.30.6-0.9
Time in open arm after self-admin0.00.00.1-0.1-0.2-0.20.30.2-0.3-0.1-0.1-0.2
Bone: periosteal estimation2.96.18.02.72.72.82.5-2.6-2.32.4-2.12.0
Bone: periosteal perimeter4.57.49.83.13.13.12.5-3.0-2.22.7-2.42.1
Bone: post-yield work1.21.62.31.31.51.50.8-1.5-1.11.2-1.01.2
Progressive ratio test 1 active lever presses1.31.34.91.10.50.71.4-0.2-1.60.5-2.20.4
Progressive ratio test 1 breakpoint1.81.95.61.40.70.91.6-0.4-2.00.7-2.40.8
Progressive ratio test 1 inactive lever presses0.60.63.00.80.30.10.80.1-0.4-0.1-1.7-0.9
Progressive ratio test 2 active lever presses1.71.82.81.41.31.41.2-1.4-1.31.7-0.91.3
Progressive ratio test 2 breakpoint2.02.23.01.61.61.51.3-1.6-1.51.7-1.11.4
Progressive ratio test 2 inactive lever presses1.01.22.31.11.11.11.0-1.2-0.81.5-0.80.8
Incentive Sensitization - Responses1.91.93.21.41.61.41.0-1.6-1.11.8-0.41.7
Incentive Sensitization - Breakpoint1.92.03.21.41.61.50.9-1.7-1.01.8-0.21.7
Sum of active levers in priming session hrs 5-61.91.83.6-1.5-1.5-1.5-1.01.60.5-1.9-0.3-1.3
Progressive ratio0.60.73.30.4-0.10.11.10.4-1.2-0.4-1.8-0.2
Food seeking constrained by brief footshock0.40.51.0-0.9-0.8-0.7-1.00.8-0.2-0.60.20.6
Seeking ratio, punishment vs. effort0.30.31.2-0.5-0.2-0.3-1.1-0.00.5-0.11.00.3
Retroperitoneal fat weight4.113.319.9-3.3-3.5-3.7-3.63.64.1-4.02.0-4.5
Reaction time number correct0.10.20.80.40.30.30.3-0.1-0.6-0.5-0.9-0.1
Reaction time mean minus median1.11.55.9-1.2-1.0-0.9-1.30.71.5-0.22.4-0.2
Reaction time mean minus median AUC2.32.98.6-1.9-1.6-1.6-1.81.22.0-0.72.9-0.5
Reaction time num false alarms3.64.98.32.42.82.41.4-2.9-1.52.6-1.32.0
Reaction time num false alarms AUC4.05.58.62.52.82.61.7-2.9-1.82.6-1.62.0
Reaction time trials correct on left0.10.20.80.40.30.30.3-0.1-0.6-0.5-0.9-0.1
Reaction time trials on left0.10.20.70.40.30.40.3-0.2-0.5-0.5-0.8-0.1
Reaction time mean2.43.411.4-1.9-1.4-1.6-2.20.92.3-0.23.4-0.3
Reaction time mean AUC3.34.412.3-2.2-1.9-2.0-2.51.42.5-0.73.5-0.6
Median of all reaction times2.12.99.4-1.8-1.4-1.6-2.10.92.0-0.23.1-0.3
Reaction time omissions1.01.32.7-1.1-0.8-0.8-1.60.71.6-0.61.5-1.0
Reaction time false alarm rate2.73.86.82.02.32.01.3-2.5-1.22.6-0.91.8
Reaction time premature initiation rate0.10.10.60.20.10.1-0.4-0.20.80.40.5-0.2
Reaction time premature initiations0.10.10.20.30.30.3-0.3-0.30.50.10.0-0.2
Std. dev. reaction times1.11.66.6-1.2-0.8-0.8-1.40.41.70.22.6-0.2
Reaction time trials completed0.10.20.70.40.30.40.3-0.2-0.5-0.5-0.8-0.1
Reaction time trials AUC0.30.40.80.60.60.60.5-0.4-0.9-0.2-0.90.4
Run reversals in cocaine runway, females0.30.30.9-0.1-0.10.2-0.70.10.9-0.70.4-0.9
Run reversals in cocaine runway, males0.90.91.5-1.0-0.9-1.2-1.20.80.9-0.51.2-0.0
Latency to leave start box in cocaine runway0.10.20.7-0.0-0.1-0.4-0.30.00.60.20.8-0.1
Latency to leave start box in cocaine runway, F0.30.40.80.90.70.30.8-0.7-0.00.90.00.3
Latency to leave start box in cocaine runway, M1.61.52.7-1.3-1.3-1.2-1.61.11.0-1.01.6-0.6
Std. dev. time between licks in bursts1.82.23.91.61.62.01.2-1.6-1.41.4-1.01.4
Total sessions with >9 infusions1.31.57.41.00.40.71.6-0.0-1.30.4-2.7-0.1
Short access day 1 total inactive lever presses0.30.41.70.50.1-0.20.70.10.30.3-1.3-0.7
Short access day 10 total inactive lever presses0.10.10.40.10.30.2-0.1-0.20.5-0.2-0.4-0.6
Short access day 1 total infusions1.21.32.81.20.60.81.5-0.4-1.71.0-1.41.1
Short access day 10 total infusions2.42.78.81.61.01.42.1-0.6-2.20.6-3.00.6
Short access total infusions1.21.43.61.00.50.91.5-0.3-1.90.6-1.90.7
Short access day 1 locomotion0.80.83.11.00.50.91.1-0.3-0.90.3-1.8-0.2
Short access day 10 total locomotion0.70.81.6-0.8-1.1-0.9-0.51.30.2-1.2-0.6-0.8
Short access total locomotion0.60.62.90.1-0.5-0.10.60.8-0.6-0.7-1.7-0.8
One hour access (0.3 mA shock)1.01.21.81.21.21.31.2-1.2-0.51.3-0.80.4
Compulsive drug intake4.74.813.2-1.7-1.8-1.9-1.31.93.2-2.00.7-3.6
One hour access (shock baseline)2.52.95.71.71.51.61.5-1.5-2.21.8-0.52.4
Social response proportion1.51.62.5-1.6-1.3-1.6-1.61.21.1-1.01.3-0.5
Social responses2.93.85.02.12.21.71.7-2.2-1.62.2-1.61.9
Social time0.20.20.6-0.10.1-0.2-0.3-0.20.80.80.7-0.1
Soleus weight0.10.40.90.70.70.90.3-0.70.10.3-0.9-0.5
Bone: stiffness5.18.110.32.93.03.22.6-3.0-2.82.8-2.42.7
Tibialis anterior weight0.20.61.5-0.7-0.9-0.60.11.00.4-1.0-0.1-1.2
Time to tail flick, vehicle, before self-admin2.32.34.2-1.4-1.5-1.8-1.21.51.7-1.70.3-2.1
Time to tail flick, vehicle, after self-admin4.54.87.2-2.7-2.2-2.1-2.51.92.0-2.32.3-1.4
Time to tail flick, test, before self-admin1.61.62.5-1.4-1.2-1.6-1.61.21.1-1.11.5-0.3
Time to tail flick, test, after self-admin0.20.20.6-0.4-0.3-0.5-0.50.40.6-0.4-0.0-0.8
Delta time to tail flick, vehicle, before/after SA0.60.62.5-0.5-0.00.2-0.8-0.3-0.10.21.61.2
Delta time to tail flick, test, before/after SA0.10.10.40.30.30.20.4-0.30.20.6-0.0-0.3
Tibia length7.521.327.65.24.74.24.7-4.2-5.34.3-4.24.6
Ambulatory time before self-admin7.98.212.53.12.83.33.5-2.6-2.82.4-3.31.7
Ambulatory time after self-admin3.43.84.91.92.21.91.8-2.2-1.81.8-2.21.7
Bone: tissue strength0.60.60.80.80.90.90.7-0.9-0.40.8-0.10.8
Total heroin consumption1.01.23.0-1.1-1.3-0.9-0.51.40.1-1.7-0.4-1.1
Bone: trabecular number0.20.31.6-0.2-0.3-0.3-0.60.2-0.10.21.30.6
Bone: trabecular spacing0.30.31.10.0-0.2-0.50.30.50.1-0.7-1.1-0.8
Bone: trabecular thickness0.91.01.90.81.01.20.7-1.2-1.01.1-0.21.4
Bone: trabecular tissue density1.62.33.51.81.91.71.3-1.9-0.91.8-1.10.8
Water consumed over 24 hours1.21.44.51.00.60.61.7-0.2-1.80.2-2.10.6
Number of responses in last shaping day0.90.93.10.50.20.30.9-0.3-1.61.0-0.21.8