Hub : Genes

Fign

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Fign 0.33 0.15 1.3e-05 0.12 0.18 0.14 0.14 9.9e-04 3.9e-05 2.8e-04 2.7e-04
2 NAcc alternative TSS XM_008761889.4 0.01 0.01 3.4e-03 0.02 0.01 0.01 0.02 5.7e-04 5.7e-03 4.7e-03 1.2e-03
3 Liver gene expression Fign 0.06 0.04 2.8e-06 0.05 0.03 0.03 0.04 3.9e-06 9.2e-05 6.2e-04 4.1e-05
4 NAcc gene expression Fign 0.04 0.02 8.2e-08 0.05 0.04 0.05 0.05 6.5e-08 1.9e-07 4.5e-08 9.2e-08
5 Adipose alternative TSS XM_063283273.1 0.04 0.03 9.5e-04 0.01 0.02 0.01 0.01 1.7e-02 2.7e-03 9.6e-03 6.9e-03
6 IL gene expression Fign 0.18 0.11 3.8e-03 0.06 0.07 0.03 0.04 1.2e-02 8.6e-03 6.9e-02 4.2e-02
7 IL alternative TSS XM_063283273.1 0.2 0.11 1.2e-03 0.11 0.08 0.09 0.07 1.4e-03 6.7e-03 4.1e-03 9.7e-03
8 Adipose gene expression Fign 0.11 0.05 1.4e-12 0.09 0.09 0.08 0.09 2.0e-10 4.4e-10 2.1e-09 2.1e-10
9 LHb gene expression Fign 0.17 0.1 3.4e-03 0.13 0.05 0.01 0.07 4.5e-04 2.6e-02 1.5e-01 9.9e-03
10 PL gene expression Fign 0.04 0.03 1.2e-03 0.03 0.03 0.03 0.02 3.6e-04 3.7e-04 4.8e-04 1.4e-03
11 OFC alternative TSS XM_008761889.4 0.22 0.15 5.5e-03 0.04 0.07 0.05 0.07 3.9e-02 8.9e-03 2.2e-02 1.1e-02
12 LHb mRNA stability Fign 0.47 0.18 4.7e-05 0.21 0.11 0.13 0.11 1.0e-05 1.3e-03 5.2e-04 1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.70.50.60.3-0.6-0.20.3-0.9-0.1-0.20.1-0.5-0.5
Area under the delay curve0.10.10.6-0.3-0.1-0.50.20.5-0.40.2-0.50.0-0.1-0.0-0.8
BMI with tail0.20.63.0-0.20.6-0.21.20.8-0.8-0.4-0.5-0.20.2-0.9-1.7
BMI without tail0.10.30.70.30.80.10.1-0.20.1-0.60.1-0.80.7-0.6-0.8
Body weight0.83.38.11.52.31.5-0.2-0.60.6-2.20.6-2.32.1-2.8-2.6
Weight adjusted by age1.52.34.2-1.4-1.7-1.61.20.8-0.81.7-1.81.3-1.52.11.9
Bone surface0.81.52.61.41.21.5-1.6-1.21.3-1.61.1-0.90.9-1.0-0.2
Bone volume0.50.92.11.01.11.1-1.0-0.60.8-1.40.4-0.80.8-1.1-0.7
Breakpoint value in progressive ratio session2.42.94.8-2.0-1.6-1.61.82.1-2.21.4-2.01.6-1.51.1-0.8
Number of licking bursts0.10.10.2-0.2-0.1-0.5-0.30.2-0.10.50.20.4-0.50.30.1
Context. condit. distance diff. score0.30.40.70.60.70.5-0.5-0.20.4-0.80.3-0.60.6-0.8-0.8
Locomotion velocity, session 10.20.21.00.1-0.2-0.1-0.3-0.30.50.10.70.5-0.60.61.0
Locomotion distance, session 10.10.10.30.1-0.10.0-0.4-0.10.20.20.50.3-0.40.20.2
Locomotion velocity, session 21.21.42.5-1.2-1.3-1.30.81.0-0.90.9-1.21.6-1.61.40.7
Locomotion distance, session 20.70.91.41.11.01.2-1.0-0.80.9-1.00.8-0.90.8-1.1-0.6
Locomotion velocity, session 30.70.81.1-0.9-1.0-1.00.80.7-0.61.0-0.91.0-0.91.10.7
Locomotion distance, session 30.00.00.1-0.1-0.2-0.2-0.2-0.00.10.1-0.20.00.10.30.2
Stereotopy head waving bouts, day 31.61.94.41.21.51.3-0.6-0.60.6-1.21.0-1.71.8-2.1-1.9
Stereotopy head waving duration, day 30.91.02.21.11.11.0-0.7-0.60.6-0.81.0-1.21.2-1.5-1.2
Locomotion velocity, session 70.20.21.30.1-0.1-0.2-0.4-0.60.5-0.10.5-0.0-0.00.61.1
Locomotion distance, session 70.10.20.40.40.30.3-0.5-0.60.6-0.30.5-0.30.3-0.10.5
Stereotopy head waving bouts, day 70.50.62.80.40.60.7-0.20.1-0.1-0.60.3-0.70.7-1.2-1.7
Stereotopy head waving duration, day 70.40.50.90.60.70.8-0.5-0.30.3-0.90.6-0.80.8-0.9-0.9
Locomotion velocity, session 80.10.10.20.20.1-0.0-0.4-0.30.3-0.40.4-0.00.00.10.2
Locomotion distance, session 80.30.41.40.50.70.6-0.2-0.00.2-0.70.2-0.50.5-1.0-1.2
Degree of sensitization distance0.20.20.70.20.50.40.20.1-0.2-0.30.2-0.40.3-0.7-0.8
Degree of sensitization stereotypy0.40.51.7-0.6-0.5-0.30.71.1-0.90.3-0.70.4-0.4-0.2-1.3
Conditioned locomotion0.10.10.50.00.00.0-0.20.1-0.00.1-0.5-0.60.7-0.2-0.6
Cocaine response after cond. corrected2.53.16.3-2.0-1.6-1.92.51.9-2.11.2-2.41.4-1.41.1-0.2
Cocaine response after cond. not corrected0.40.51.6-0.6-0.3-0.41.30.8-0.90.1-1.1-0.00.1-0.2-0.8
Cocaine response before conditioning5.26.28.72.72.62.9-2.6-2.22.3-2.02.5-2.82.8-2.7-1.2
Saline control response0.20.30.8-0.3-0.3-0.30.70.8-0.60.3-0.90.3-0.3-0.3-0.9
Bone: connectivity density0.10.10.30.40.20.0-0.5-0.00.3-0.50.00.1-0.1-0.3-0.5
Bone: cortical apparent density0.00.10.30.1-0.1-0.2-0.20.00.20.20.00.5-0.60.10.2
Bone: cortical area5.48.211.13.23.23.3-2.6-2.72.7-3.02.3-3.33.2-3.1-1.0
Bone: cortical porosity2.22.33.51.51.71.9-1.4-1.21.1-1.71.2-1.81.8-1.7-1.1
Bone: cortical porosity3.33.55.12.02.12.3-2.0-1.81.8-2.11.8-2.01.9-1.7-0.4
Bone: cortical thickness2.64.37.72.22.42.5-1.6-1.51.6-2.21.3-2.32.2-2.8-1.6
Bone: cortical thickness4.04.77.52.32.52.3-1.9-1.61.6-2.41.6-2.52.3-2.7-1.7
Bone: cortical tissue density0.10.10.6-0.1-0.3-0.4-0.10.20.00.3-0.10.6-0.80.20.3
Condit. Reinf. active minus inactive responses2.52.73.61.81.91.6-1.9-1.61.6-1.41.5-1.91.9-1.7-0.7
Condit. Reinf. active-inactive response ratio0.60.61.30.80.90.7-0.7-0.60.6-0.40.4-1.21.1-0.9-0.5
Condit. Reinf. active responses3.24.07.02.32.01.8-2.6-2.42.4-1.92.3-1.81.8-1.30.5
Condit. Reinf. inactive responses2.63.26.11.91.41.3-2.3-2.42.3-2.02.5-0.80.8-0.41.8
Incentive salience index mean2.43.04.52.02.01.6-2.1-1.71.8-1.51.5-1.91.9-1.7-0.6
Condit. Reinf. lever presses0.30.40.70.80.80.2-0.8-0.70.8-0.40.2-0.80.8-0.7-0.2
Condit. Reinf. active minus inactive responses4.86.28.93.02.62.3-2.8-2.62.8-2.32.5-2.52.6-2.4-0.5
Condit. Reinf. active-inactive response ratio2.12.44.11.91.51.4-2.0-1.82.0-1.51.6-1.31.4-1.20.3
Condit. Reinf. active responses4.96.89.13.03.02.4-2.6-2.52.6-2.42.4-2.92.9-2.9-1.0
Condit. Reinf. inactive responses0.81.02.60.91.30.7-0.4-0.40.4-0.70.6-1.31.3-1.6-1.3
Condit. Reinf. lever presses6.38.711.53.43.43.1-3.2-2.93.1-3.03.0-3.02.9-2.9-0.7
Condit. Reinf. lever reinforcers received3.75.17.32.72.62.0-2.5-2.32.5-2.02.2-2.42.4-2.3-0.5
Conditioned reinforcement - actives1.83.04.71.72.21.8-1.4-1.31.2-1.91.6-1.91.9-2.1-1.4
Conditioned reinforcement - inactives0.40.51.20.61.00.8-0.6-0.70.4-0.70.6-1.11.0-0.7-0.4
Conditioned locomotion0.91.13.50.81.21.2-0.1-0.20.1-1.00.7-0.90.9-1.7-1.9
Patch foraging indifference point 0 sec0.20.40.9-0.6-0.1-0.20.90.9-0.90.1-0.70.6-0.5-0.2-0.8
Patch foraging indifference point AUC1.52.26.61.20.40.3-2.6-2.02.2-0.51.7-0.60.50.82.2
Delay disc. indifference point, 0s delay0.40.40.80.50.50.3-0.7-0.80.7-0.60.9-0.70.6-0.10.8
Delay disc. indifference point, 16s delay0.10.21.2-0.20.30.00.00.3-0.4-0.1-0.2-0.30.3-0.3-1.1
Delay disc. indifference point, 2s delay0.50.53.2-0.2-0.5-0.7-0.4-0.40.40.40.20.4-0.41.21.8
Delay disc. indifference point, 24s delay0.10.10.6-0.2-0.3-0.2-0.10.3-0.20.3-0.2-0.10.00.1-0.8
Delay disc. indifference point, 4s delay0.50.51.5-0.7-0.8-1.20.70.8-0.60.8-0.80.6-0.60.6-0.2
Delay disc. indifference point, 8s delay0.30.42.2-0.40.1-0.40.40.8-0.70.1-0.90.1-0.2-0.4-1.5
Indifference point function ln k0.10.31.3-0.5-0.1-0.01.10.6-0.70.2-0.50.20.0-0.2-0.5
Indifference point function log k0.10.31.3-0.5-0.1-0.01.10.6-0.70.2-0.50.20.0-0.2-0.5
Patch foraging total patch changes 0 sec0.50.91.9-1.0-0.5-0.71.41.3-1.30.5-1.21.0-0.90.1-0.7
Patch foraging total patch changes 12 sec1.31.73.11.41.41.2-1.8-1.51.5-1.51.3-1.11.1-0.80.4
Patch foraging total patch changes 18 sec0.91.43.81.21.30.7-1.9-1.51.4-0.91.3-0.90.9-0.40.7
Patch foraging total patch changes 24 sec1.01.72.91.51.71.2-1.5-1.11.2-1.61.0-1.21.1-1.5-1.0
Patch foraging total patch changes 6 sec0.20.20.6-0.5-0.5-0.60.00.4-0.40.3-0.50.8-0.70.60.2
Patch foraging time to switch 0 sec0.30.72.1-0.70.0-0.21.41.0-1.3-0.1-0.6-0.30.5-0.7-1.5
Patch foraging water rate 0 sec1.53.24.62.02.11.9-2.1-1.81.9-1.71.6-1.81.7-1.7-0.5
Patch foraging water rate 12 sec0.91.92.91.61.51.6-1.7-1.71.7-1.41.5-0.90.9-0.90.6
Patch foraging water rate 18 sec1.62.43.81.91.81.9-1.9-1.61.8-1.71.5-0.91.0-1.4-0.0
Patch foraging water rate 24 sec0.70.92.21.11.01.1-1.5-1.01.2-1.01.1-0.10.1-0.50.3
Patch foraging water rate 6 sec1.52.13.21.71.81.3-1.7-1.71.7-1.21.6-1.31.2-1.2-0.1
Seeking ratio, delayed vs. immediate footshock0.50.71.80.80.91.3-0.6-0.60.5-1.00.6-0.60.7-0.9-0.6
Distance traveled before self-admin3.54.66.82.12.62.6-1.8-1.71.6-2.62.4-2.12.1-2.4-1.1
Distance traveled after self-admin2.63.24.61.91.92.1-1.5-2.11.8-1.71.9-1.92.0-1.30.6
Extensor digitorum longus weight0.41.62.51.41.31.6-1.2-1.51.4-1.61.5-1.01.0-0.80.6
Bone: elastic displacement1.21.42.6-1.2-1.1-1.11.61.4-1.31.4-1.51.0-0.90.5-0.4
Bone: elastic work0.30.40.9-0.5-0.6-0.40.90.7-0.50.5-0.70.7-0.70.30.2
Bone: endosteal estimation1.22.64.41.71.51.7-2.1-2.01.9-1.61.8-1.41.5-0.70.8
Bone: endosteal perimeter2.24.88.42.41.92.2-2.7-2.92.8-1.72.4-1.92.0-0.91.5
Epididymis fat weight8.729.739.3-6.1-5.6-6.16.26.1-6.05.2-6.35.2-5.24.3-0.7
Delta time in closed arm before/after self-admin0.90.91.6-1.0-0.9-1.21.31.2-1.21.0-1.10.3-0.30.2-0.8
Delta time in open arm before/after self-admin0.40.40.90.60.70.5-0.8-0.90.9-0.60.7-0.20.2-0.01.0
Diff in mean of infusions in LGA sessions9.611.716.7-3.8-3.4-3.64.04.1-4.13.6-3.83.0-3.12.1-1.4
Delay discount exponential model param0.20.20.50.50.30.7-0.3-0.60.6-0.40.6-0.30.3-0.20.7
Extinction: sum of active levers before priming0.10.10.50.20.50.60.1-0.20.1-0.70.3-0.10.2-0.40.1
Active lever presses in extinction session 60.60.61.80.30.70.70.40.1-0.2-0.70.0-0.70.9-1.3-1.4
Bone: final force3.96.28.62.72.52.8-2.9-2.92.8-2.52.5-2.52.4-1.70.5
Bone: final moment3.55.67.72.62.42.7-2.8-2.82.7-2.42.4-2.32.3-1.50.7
Food consumed during 24 hour testing period1.01.32.01.31.41.3-1.2-1.01.0-0.90.9-1.41.2-1.4-0.7
Glucose0.30.51.00.80.60.8-0.7-1.00.8-0.20.7-0.90.9-0.40.5
Heart weight0.00.00.1-0.00.1-0.4-0.2-0.0-0.00.10.30.00.10.0-0.0
Delay discount hyperbolic model param0.20.20.50.50.30.7-0.2-0.50.4-0.40.5-0.40.4-0.40.3
Intermittent access intake day 1-15 change1.93.95.92.02.01.8-2.3-2.42.2-2.12.4-1.81.6-0.91.4
Intermittent access intake escalation1.63.35.31.91.81.7-2.2-2.32.1-1.92.3-1.61.4-0.71.6
Intermittent access intake escalation 21.51.74.81.21.01.0-1.5-1.81.6-1.11.6-0.70.60.12.2
Intermitt. access day 1 inactive lever presses0.20.92.0-1.1-0.7-1.21.21.0-1.21.0-1.40.3-0.30.6-0.5
Intermitt. access day 15 inactive lever presses0.10.20.60.40.40.4-0.3-0.50.4-0.50.1-0.80.8-0.20.2
Intermitt. access escalation Index0.60.82.0-0.8-1.4-1.40.50.7-0.51.0-1.00.5-0.71.00.5
Intermittent access day 1 total infusions0.20.32.00.10.60.50.40.2-0.3-0.6-0.0-0.10.3-0.8-1.4
Intermittent access day 15 total infusions1.62.33.81.51.82.0-1.4-1.41.2-1.91.7-1.41.4-1.5-0.7
Intermittent access terminal intake (last 3 days)1.62.03.21.51.81.8-1.3-1.41.3-1.81.5-1.21.2-1.4-0.4
Intermittent access total infusions1.21.52.71.21.51.6-0.9-0.90.8-1.61.2-1.01.0-1.4-1.2
Intermittent access day 1 locomotion0.70.93.8-0.7-0.3-0.11.41.3-1.30.4-0.70.7-0.6-0.6-2.0
Intermittent access day 15 total locomotion1.01.93.41.51.51.8-1.0-1.51.4-1.61.9-1.11.1-1.20.2
Intermittent access total locomotion0.50.61.30.81.01.0-0.0-0.50.4-1.00.8-0.60.7-1.1-0.8
Intermittent access standard deviation2.24.67.72.22.82.8-2.0-2.42.1-2.62.6-1.71.6-1.50.7
Left kidney weight1.04.67.42.42.31.9-2.1-2.72.6-2.22.2-2.32.2-1.31.0
Right kidney weight1.77.912.63.03.02.3-2.6-3.63.3-2.93.2-3.03.0-1.61.6
Cocaine induced anxiety2.63.75.9-1.8-1.8-1.92.02.4-2.02.0-2.22.0-2.00.8-1.7
Post-drug Anxiety0.10.10.60.20.20.40.10.00.0-0.00.2-0.40.4-0.4-0.8
Baseline Anxiety5.86.89.42.62.62.8-2.3-3.02.5-2.73.0-3.13.0-1.80.9
Tail length1.97.510.13.02.92.7-3.0-2.92.8-3.02.4-3.23.1-2.3-0.5
Length with tail1.66.911.02.82.92.6-2.1-2.32.3-3.01.8-3.33.2-3.0-1.5
Length without tail1.44.47.42.32.42.3-1.3-1.61.7-2.51.5-2.42.3-2.7-1.4
Times rat made contact with spout2.12.54.6-1.6-1.2-1.31.72.0-1.91.8-2.21.5-1.50.6-1.0
Lifetime Intake1.61.93.41.21.71.8-0.8-0.70.7-1.71.1-1.21.2-1.8-1.8
Liver weight, left1.01.72.81.41.61.6-0.7-1.00.9-1.61.2-1.31.3-1.7-0.8
Liver weight, right0.30.51.20.70.90.8-0.0-0.70.5-0.60.5-1.11.0-0.8-0.1
Locomotor activity2.54.05.62.42.02.3-2.3-2.12.2-1.82.4-1.71.6-2.0-0.3
Locomotor testing distance3.97.110.53.12.62.7-3.2-3.13.2-2.43.2-2.32.3-2.00.8
Locomotor testing rearing4.69.214.43.42.92.9-3.6-3.83.7-2.63.5-2.82.8-1.91.7
Locomotion in novel chamber0.30.42.3-0.00.30.70.20.4-0.5-0.3-0.0-0.20.6-0.9-1.5
Locomotion in novel chamber post-restriction0.20.42.60.30.50.2-0.10.5-0.3-0.0-0.20.0-0.0-1.2-1.6
Fecal boli incidents, locomotor time 11.21.73.0-1.3-1.6-1.41.01.0-1.01.5-0.91.7-1.51.60.7
Change in fecal boli incidents, locomotor task1.51.52.61.21.51.6-0.9-0.90.9-1.31.1-1.41.2-1.4-0.9
Time >=10cm from walls, locomotor time 10.60.71.30.71.11.0-0.8-0.30.4-1.00.8-0.50.7-1.1-1.0
Bouts of movement, locomotor time 16.37.211.9-2.8-2.5-2.63.03.5-3.22.5-2.82.7-2.71.2-1.9
Total resting periods, locomotor time 16.37.011.4-2.8-2.5-2.62.93.4-3.12.6-2.82.7-2.71.3-1.7
Rest time, locomotor task time 13.03.74.7-2.1-2.0-2.02.02.1-2.02.1-2.12.2-2.01.6-0.1
Distance moved, locomotor task time 12.84.25.32.12.22.2-2.1-2.32.2-2.22.2-2.32.1-1.50.8
Vertical activity count, locomotor time 10.20.40.80.60.70.4-0.7-0.80.8-0.60.9-0.60.4-0.10.9
Time >=10cm from walls, locomotor time 21.31.93.91.62.01.5-1.3-1.51.5-1.41.5-1.01.2-1.20.2
Bouts of movement, locomotor time 23.75.99.4-2.9-2.4-2.43.03.0-3.12.7-2.71.7-1.71.5-1.2
Total resting periods, locomotor time 24.37.611.5-3.2-2.8-2.63.33.3-3.43.0-3.02.2-2.11.8-1.1
Rest time, locomotor task time 21.72.13.2-1.7-1.6-1.41.51.8-1.71.3-1.71.5-1.31.0-0.5
Distance moved, locomotor task time 22.63.14.22.12.01.8-1.7-1.92.0-1.91.8-1.71.7-1.60.5
Vertical activity count, locomotor time 20.30.43.1-0.1-0.2-0.5-0.1-0.40.30.50.00.3-0.40.91.8
Light reinforcement 10.00.00.20.1-0.1-0.0-0.0-0.10.30.2-0.1-0.0-0.10.20.5
Light reinforcement 20.50.81.9-0.6-1.4-1.20.10.5-0.11.4-0.90.7-0.81.20.9
Bone: marrow area1.22.74.51.71.51.7-2.1-2.02.0-1.71.8-1.41.5-0.70.8
Bone: maximum diameter2.95.57.62.62.52.8-2.2-2.32.3-2.61.9-2.52.6-2.4-0.6
Bone: maximum force3.76.68.92.92.62.8-2.9-3.02.9-2.72.5-2.72.6-1.80.6
Bone: maximum moment3.66.38.82.82.52.7-2.8-3.02.9-2.62.5-2.52.5-1.70.8
Mean time between licks in bursts0.82.03.91.51.11.2-1.3-1.81.8-1.52.0-1.21.0-0.41.2
Mean num. licks in bursts0.30.51.8-0.7-0.6-0.21.10.8-0.90.5-1.30.4-0.30.1-0.5
Cd content in liver0.40.40.6-0.8-0.5-0.80.50.7-0.80.4-0.60.8-0.70.6-0.1
Co content in liver1.61.93.91.31.51.5-1.2-1.11.0-1.20.9-1.92.0-1.5-0.9
Cu content in liver0.30.41.20.2-0.30.1-0.8-0.60.7-0.00.80.2-0.30.81.1
Fe content in liver0.40.51.2-0.7-0.9-0.90.50.5-0.40.7-0.30.8-0.81.10.7
K content in liver1.21.22.71.00.50.6-1.1-1.61.6-0.61.3-1.00.90.31.6
Mg content in liver1.51.54.11.10.60.9-1.1-1.81.7-0.81.5-0.70.60.32.0
Mn content in liver4.14.68.02.51.82.1-2.5-2.72.8-1.82.8-1.71.7-1.21.0
Na content in liver4.75.07.32.72.12.4-2.0-2.52.7-2.12.6-2.32.3-1.80.2
Rb content in liver1.51.72.31.51.51.0-1.5-1.51.4-1.31.2-1.41.4-1.1-0.1
Se content in liver0.50.61.0-1.0-0.8-1.00.91.0-1.00.7-0.50.6-0.60.7-0.2
Sr content in liver0.30.30.40.60.60.5-0.7-0.50.5-0.50.5-0.50.6-0.6-0.2
Zn content in liver0.50.53.10.00.50.40.30.5-0.5-0.6-0.3-0.60.6-1.0-1.8
Bone: minimum diameter1.42.63.71.91.61.8-1.7-1.91.9-1.61.6-1.61.6-1.20.5
Time in familiar zone, hab. session 10.50.51.40.70.50.4-1.2-1.00.9-0.61.0-0.60.5-0.10.4
Time in novel zone, hab. session 11.31.32.4-1.2-1.2-1.01.61.2-1.20.9-1.21.3-1.20.90.3
Total zone transitions, hab. session 11.92.74.22.01.81.8-1.9-1.41.8-1.71.5-1.31.3-1.9-0.8
Total locomotion distance, hab. session 12.13.05.42.11.51.7-2.3-2.02.3-1.52.0-1.31.2-1.20.6
Locomotion velocity, hab. session 11.72.54.41.91.41.6-2.1-1.92.1-1.31.8-1.11.1-1.00.6
Time in familiar zone, hab. session 21.31.42.1-1.1-1.2-1.21.41.4-1.21.3-1.31.3-1.50.7-0.2
Time in novel zone, hab. session 21.01.01.90.81.21.0-1.0-1.00.7-1.41.1-1.11.2-0.8-0.2
Total zone transitions, hab. session 21.62.03.91.61.61.7-1.3-0.91.1-1.41.1-1.21.1-2.0-1.5
Total locomotion distance, hab. session 20.20.30.50.70.60.7-0.6-0.40.5-0.20.7-0.40.3-0.7-0.5
Locomotion velocity, hab. session 20.20.30.70.70.50.7-0.6-0.50.6-0.20.8-0.40.3-0.6-0.2
Novel to familiar place preference ratio0.70.84.8-0.20.40.00.91.0-1.0-0.4-0.4-0.40.3-1.2-2.2
Novelty place preference0.80.84.6-0.40.2-0.01.01.1-1.1-0.2-0.4-0.10.1-1.1-2.2
Time in novel zone, NPP test0.70.84.5-0.40.30.01.01.1-1.1-0.2-0.3-0.0-0.0-1.1-2.1
Total zone transitions, NPP test0.50.71.80.90.91.1-0.9-0.20.5-0.60.6-0.50.4-1.2-1.3
Total locomotion distance, NPP test0.81.11.81.21.01.3-1.4-0.91.2-0.61.3-0.80.8-1.0-0.4
Locomotion velocity, NPP test0.91.32.01.31.01.3-1.4-1.11.3-0.61.4-1.11.1-1.0-0.3
Intraocular pressure0.71.02.31.11.01.3-1.1-0.90.9-1.51.0-0.40.6-1.0-0.2
Delta distance traveled before/after self-admin0.90.92.8-0.8-1.1-0.90.60.1-0.21.3-1.00.5-0.41.51.7
Delta ambulatory time before/after self-admin0.40.52.50.60.20.5-0.6-1.11.00.10.2-0.50.50.41.6
Parametrial fat weight2.56.08.4-2.5-2.6-2.62.62.2-2.12.9-2.02.8-2.82.61.1
Pavlov. Cond. lever latency0.91.14.9-0.7-1.1-0.50.3-0.1-0.00.30.31.2-1.21.72.2
Pavlov. Cond. magazine entry latency0.10.20.40.20.60.1-0.1-0.1-0.0-0.3-0.1-0.50.5-0.6-0.7
Pavlov. Cond. change in total contacts0.80.81.90.91.20.5-0.9-0.70.7-0.50.2-1.21.4-1.0-0.9
Pavlov. Cond. index score0.81.01.90.91.30.6-0.7-0.60.5-0.70.1-1.31.4-1.4-1.2
Pavlov. Cond. latency score1.01.33.21.01.40.8-0.6-0.40.4-0.8-0.1-1.41.5-1.7-1.8
Pavlov. Cond. lever contacts1.21.44.11.11.50.8-0.7-0.30.5-0.6-0.0-1.41.5-1.9-2.0
Pavlov. Cond. magazine entry number0.10.10.4-0.4-0.6-0.00.50.5-0.30.3-0.10.5-0.50.20.1
Pavlov. Cond. intertrial magazine entries2.32.83.91.81.61.7-1.9-2.01.9-1.92.0-1.61.5-1.00.6
Pavlov. Cond. lever-magazine prob. diff.0.80.91.90.91.30.6-0.7-0.60.5-0.70.1-1.31.4-1.3-1.2
Pavlov. Cond. response bias0.10.20.40.40.7-0.0-0.4-0.40.3-0.1-0.0-0.60.6-0.4-0.3
Pavlov. Cond. lever latency4.66.29.8-2.7-3.1-2.92.52.1-2.22.7-2.32.4-2.32.81.4
Pavlov. Cond. magazine entry latency1.21.47.40.51.40.8-0.00.3-0.4-0.6-0.3-1.31.2-1.9-2.7
Pavlov. Cond. change in total contacts2.23.54.82.12.22.0-2.2-1.81.9-1.82.0-1.81.6-1.8-0.7
Pavlov. Cond. index score2.23.05.61.72.31.9-1.3-1.01.0-1.71.0-1.91.8-2.4-2.1
Pavlov. Cond. latency score1.72.24.61.32.01.7-1.0-0.70.7-1.30.7-1.71.6-2.1-2.1
Pavlov. Cond. lever contacts4.76.510.02.83.23.0-2.6-2.12.2-2.72.4-2.52.4-2.9-1.5
Pavlov. Cond. magazine entry number0.81.05.6-0.4-1.1-0.70.1-0.30.30.30.31.0-0.91.52.4
Pavlov. Cond. intertrial magazine entries0.71.02.91.00.30.6-1.0-1.41.4-0.81.0-0.80.80.11.7
Pavlov. Cond. lever-magazine prob. diff.1.72.34.31.42.01.6-1.1-0.80.8-1.40.9-1.71.6-2.1-1.9
Pavlov. Cond. response bias4.05.59.02.43.02.6-2.1-1.71.8-2.51.9-2.52.3-2.9-1.9
Time in closed arm before self-admin0.00.00.10.10.20.3-0.1-0.10.1-0.20.2-0.00.0-0.1-0.2
Time in closed arm after self-admin0.00.00.10.0-0.1-0.10.20.1-0.10.2-0.1-0.30.3-0.2-0.3
Time in open arm before self-admin1.11.21.9-1.1-1.1-1.01.11.4-1.30.9-1.31.0-1.00.5-1.0
Time in open arm after self-admin0.10.10.3-0.30.0-0.20.40.4-0.4-0.1-0.40.5-0.50.0-0.2
Bone: periosteal estimation3.47.39.53.02.93.1-2.9-2.92.8-2.92.5-2.82.9-2.3-0.0
Bone: periosteal perimeter4.57.710.23.12.83.0-2.9-3.23.1-2.72.7-2.93.0-2.20.5
Bone: post-yield work1.11.73.11.41.10.9-1.4-1.81.7-1.11.4-1.21.3-0.51.1
Progressive ratio test 1 active lever presses2.02.55.31.31.91.8-0.9-0.70.6-1.71.1-1.61.5-2.3-2.3
Progressive ratio test 1 breakpoint1.92.45.01.31.91.7-0.9-0.70.6-1.71.1-1.51.5-2.2-2.2
Progressive ratio test 1 inactive lever presses0.71.03.60.71.20.7-0.3-0.10.2-0.90.3-1.01.0-1.5-1.9
Progressive ratio test 2 active lever presses2.42.84.21.82.12.0-1.8-1.51.5-1.81.7-1.51.4-1.7-1.0
Progressive ratio test 2 breakpoint2.62.94.41.92.12.0-1.9-1.61.6-1.91.8-1.61.4-1.7-0.9
Progressive ratio test 2 inactive lever presses1.01.62.41.31.41.6-1.4-1.11.1-1.41.1-1.21.1-1.4-1.2
Incentive Sensitization - Responses1.01.42.01.31.31.1-1.4-1.21.3-1.21.2-1.21.1-1.0-0.5
Incentive Sensitization - Breakpoint1.01.32.11.31.21.1-1.5-1.31.3-1.11.2-1.21.0-0.8-0.2
Sum of active levers in priming session hrs 5-62.82.64.1-2.0-1.6-1.72.01.7-1.91.3-1.91.4-1.31.40.2
Progressive ratio0.81.24.60.61.30.90.00.1-0.2-0.8-0.0-1.21.2-1.9-2.1
Food seeking constrained by brief footshock0.40.41.0-0.7-0.8-0.80.70.7-0.71.0-0.80.1-0.20.5-0.4
Seeking ratio, punishment vs. effort0.40.61.8-0.6-1.1-0.80.30.1-0.10.9-0.40.6-0.61.31.2
Retroperitoneal fat weight2.510.917.3-3.5-3.4-4.24.13.4-3.23.4-3.53.1-3.12.90.4
Reaction time number correct0.10.20.50.40.40.4-0.2-0.60.5-0.10.7-0.30.2-0.20.7
Reaction time mean minus median0.51.32.8-1.2-1.2-1.70.51.1-0.91.2-0.91.5-1.31.40.1
Reaction time mean minus median AUC1.33.45.4-1.9-2.0-2.31.31.7-1.52.0-1.72.2-2.22.10.4
Reaction time num false alarms3.34.68.92.41.91.9-3.0-2.92.9-1.82.2-1.61.6-0.81.8
Reaction time num false alarms AUC3.35.29.62.62.22.1-3.1-2.92.9-2.02.4-1.81.9-1.11.4
Reaction time trials correct on left0.10.20.50.40.40.4-0.2-0.60.5-0.10.7-0.30.2-0.20.7
Reaction time trials on left0.10.20.60.50.40.4-0.3-0.60.6-0.10.8-0.30.2-0.20.8
Reaction time mean2.23.55.6-2.0-2.1-2.30.91.6-1.41.9-1.82.4-2.32.30.6
Reaction time mean AUC3.04.86.9-2.4-2.5-2.61.52.0-1.92.4-2.12.6-2.52.50.5
Median of all reaction times2.33.25.1-1.9-2.0-2.10.91.5-1.41.8-1.82.3-2.32.20.6
Reaction time omissions0.60.92.4-0.9-1.1-1.60.30.5-0.40.7-0.61.0-1.01.51.1
Reaction time false alarm rate2.33.26.52.01.71.6-2.5-2.22.3-1.71.7-1.51.5-0.90.9
Reaction time premature initiation rate0.10.10.50.20.20.1-0.40.10.1-0.2-0.0-0.00.1-0.4-0.7
Reaction time premature initiations0.10.10.20.40.30.2-0.5-0.30.4-0.20.3-0.20.3-0.4-0.2
Std. dev. reaction times0.71.42.6-1.2-1.3-1.60.30.9-0.71.1-0.81.6-1.41.60.5
Reaction time trials completed0.10.20.60.50.40.4-0.3-0.60.6-0.10.8-0.30.2-0.20.8
Reaction time trials AUC0.20.40.90.70.60.6-0.5-0.80.8-0.30.9-0.40.4-0.30.8
Run reversals in cocaine runway, females0.10.10.30.3-0.20.10.1-0.20.3-0.40.60.1-0.2-0.20.3
Run reversals in cocaine runway, males1.01.01.7-0.8-1.2-1.30.70.8-0.61.0-1.21.2-1.21.00.4
Latency to leave start box in cocaine runway0.10.10.2-0.1-0.2-0.10.30.3-0.10.3-0.20.4-0.5-0.1-0.4
Latency to leave start box in cocaine runway, F0.30.40.90.80.60.6-0.3-0.30.5-0.60.4-0.40.3-1.0-0.8
Latency to leave start box in cocaine runway, M2.22.02.8-1.5-1.6-1.41.21.3-1.21.7-1.21.7-1.71.50.6
Std. dev. time between licks in bursts1.72.34.11.61.61.6-1.3-1.71.6-2.02.0-1.41.2-1.10.2
Total sessions with >9 infusions2.22.611.11.11.81.6-0.6-0.10.1-1.60.8-1.21.2-2.6-3.3
Short access day 1 total inactive lever presses0.30.43.2-0.10.10.10.30.6-0.6-0.0-0.5-0.30.5-0.8-1.8
Short access day 10 total inactive lever presses0.30.81.7-1.0-1.0-1.31.10.5-0.60.8-0.80.3-0.31.30.9
Short access day 1 total infusions0.81.16.90.51.00.9-0.10.3-0.3-0.80.2-0.40.4-1.6-2.6
Short access day 10 total infusions2.12.75.61.52.01.8-0.7-0.80.7-1.91.4-1.71.7-2.4-2.0
Short access total infusions1.01.26.00.61.21.2-0.10.1-0.2-1.10.5-0.60.7-1.8-2.4
Short access day 1 locomotion0.40.52.30.30.80.40.30.2-0.3-0.70.4-0.20.2-1.2-1.5
Short access day 10 total locomotion0.30.62.2-0.6-0.3-0.21.21.0-1.00.3-0.70.1-0.1-0.5-1.5
Short access total locomotion0.80.95.80.20.60.70.60.5-0.6-0.70.1-0.50.5-1.6-2.4
One hour access (0.3 mA shock)3.03.55.02.12.02.2-1.6-1.91.8-2.22.0-1.81.7-1.8-0.6
Compulsive drug intake2.53.05.2-2.1-2.0-2.02.31.7-1.91.9-1.71.1-1.21.60.3
One hour access (shock baseline)2.53.85.62.32.32.4-2.0-1.81.9-2.32.0-1.51.5-2.1-0.9
Social response proportion1.61.93.1-1.7-1.5-1.81.31.4-1.51.5-1.60.9-0.91.40.0
Social responses2.93.76.62.02.11.5-2.2-2.12.0-2.01.8-2.62.2-1.4-0.2
Social time0.10.10.4-0.3-0.5-0.6-0.30.1-0.10.5-0.1-0.20.10.4-0.2
Soleus weight0.10.30.50.50.40.6-0.2-0.70.6-0.50.7-0.50.4-0.20.7
Bone: stiffness5.48.811.23.23.13.2-3.3-3.33.1-3.02.8-3.33.2-2.30.1
Tibialis anterior weight0.10.41.6-0.6-0.20.10.90.9-1.00.3-0.40.3-0.2-0.2-1.2
Time to tail flick, vehicle, before self-admin0.30.31.0-0.6-0.7-0.70.70.5-0.70.6-1.0-0.40.30.2-0.3
Time to tail flick, vehicle, after self-admin4.96.59.2-2.9-2.6-2.52.52.2-2.32.7-2.32.8-2.83.01.6
Time to tail flick, test, before self-admin1.51.52.7-1.1-1.6-1.31.10.9-0.81.6-1.41.2-1.11.40.9
Time to tail flick, test, after self-admin0.20.20.6-0.5-0.5-0.60.70.5-0.50.8-0.40.2-0.10.3-0.0
Delta time to tail flick, vehicle, before/after SA1.41.43.4-0.9-0.9-0.80.50.4-0.40.9-0.21.8-1.71.81.8
Delta time to tail flick, test, before/after SA0.10.10.70.00.40.10.00.2-0.2-0.10.1-0.10.1-0.4-0.8
Tibia length7.520.726.65.25.04.9-4.5-4.24.4-4.93.5-5.15.1-5.0-1.6
Ambulatory time before self-admin3.85.79.32.42.82.8-2.2-2.01.9-3.02.7-2.22.2-2.5-0.9
Ambulatory time after self-admin2.83.34.51.82.02.1-1.7-2.11.8-1.81.8-2.12.1-1.20.6
Bone: tissue strength0.60.61.10.80.40.7-1.0-1.01.1-0.61.0-0.60.4-0.10.8
Total heroin consumption1.01.23.1-1.3-0.5-0.61.41.5-1.80.5-1.20.7-0.6-0.0-1.4
Bone: trabecular number0.10.10.7-0.1-0.1-0.4-0.00.5-0.30.1-0.40.4-0.4-0.2-0.9
Bone: trabecular spacing0.20.20.60.00.30.20.50.1-0.3-0.3-0.4-0.70.6-0.6-0.7
Bone: trabecular thickness0.50.61.30.80.70.4-1.2-1.01.0-0.90.9-0.30.20.00.8
Bone: trabecular tissue density1.62.43.71.71.61.9-1.9-1.71.8-1.91.6-1.21.1-1.10.2
Water consumed over 24 hours1.41.94.41.21.71.6-0.6-0.60.5-1.00.6-1.81.8-2.1-1.6
Number of responses in last shaping day0.50.54.80.10.20.4-0.00.5-0.4-0.2-0.2-0.1-0.1-1.0-2.2