Hub : Genes

Fign

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Fign 0.33 0.15 1.3e-05 0.12 0.18 0.14 0.15 9.9e-04 3.9e-05 2.8e-04 2.6e-04
2 NAcc alternative TSS XM_008761889.4 0.01 0.01 3.4e-03 0.02 0.01 0.01 0.02 5.7e-04 5.7e-03 4.7e-03 1.1e-03
3 Liver gene expression Fign 0.06 0.04 2.8e-06 0.05 0.03 0.03 0.04 3.9e-06 9.2e-05 7.1e-04 4.0e-05
4 NAcc gene expression Fign 0.04 0.02 8.2e-08 0.05 0.04 0.05 0.05 6.5e-08 1.9e-07 4.5e-08 9.3e-08
5 Adipose alternative TSS XM_063283273.1 0.04 0.03 9.5e-04 0.01 0.02 0.01 0.01 1.7e-02 2.7e-03 9.6e-03 7.1e-03
6 IL gene expression Fign 0.18 0.11 3.8e-03 0.06 0.07 0.03 0.04 1.2e-02 8.6e-03 6.9e-02 4.6e-02
7 IL alternative TSS XM_063283273.1 0.2 0.11 1.2e-03 0.11 0.08 0.09 0.07 1.4e-03 6.7e-03 4.1e-03 9.9e-03
8 Adipose gene expression Fign 0.11 0.05 1.4e-12 0.09 0.09 0.08 0.09 2.0e-10 4.4e-10 2.1e-09 2.3e-10
9 LHb gene expression Fign 0.17 0.1 3.4e-03 0.13 0.05 0.01 0.07 4.5e-04 2.6e-02 1.5e-01 1.2e-02
10 PL gene expression Fign 0.04 0.03 1.2e-03 0.03 0.03 0.03 0.02 3.6e-04 3.7e-04 4.8e-04 1.5e-03
11 OFC alternative TSS XM_008761889.4 0.22 0.15 5.5e-03 0.04 0.07 0.05 0.07 3.9e-02 8.9e-03 2.2e-02 1.1e-02
12 LHb mRNA stability Fign 0.47 0.18 4.7e-05 0.21 0.11 0.13 0.11 1.0e-05 1.3e-03 5.2e-04 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.70.5-0.6-0.30.6-0.20.30.90.10.2-0.1-0.50.5
Area under the delay curve0.10.10.6-0.30.10.5-0.20.5-0.4-0.20.5-0.00.1-0.00.8
BMI with tail0.20.63.0-0.2-0.60.2-1.20.8-0.80.40.50.2-0.2-0.91.7
BMI without tail0.10.30.70.3-0.8-0.1-0.1-0.20.10.6-0.10.8-0.7-0.60.8
Body weight0.83.38.11.5-2.3-1.50.2-0.60.62.2-0.62.3-2.1-2.82.6
Weight adjusted by age0.82.34.2-1.41.71.6-1.20.8-0.8-1.71.8-1.31.52.1-1.9
Bone surface0.81.52.61.4-1.2-1.51.6-1.21.31.6-1.10.9-0.9-1.00.2
Bone volume0.50.92.11.0-1.1-1.11.0-0.60.81.4-0.40.8-0.8-1.10.7
Breakpoint value in progressive ratio session1.62.94.8-2.01.61.6-1.82.1-2.2-1.42.0-1.61.51.10.8
Number of licking bursts0.00.10.2-0.20.10.50.30.2-0.1-0.5-0.2-0.40.50.3-0.1
Context. condit. distance diff. score0.30.40.70.6-0.7-0.50.5-0.20.40.8-0.30.6-0.6-0.80.8
Locomotion velocity, session 10.20.21.00.10.20.10.3-0.30.5-0.1-0.7-0.50.60.6-1.0
Locomotion distance, session 10.10.10.30.10.1-0.00.4-0.10.2-0.2-0.5-0.30.40.2-0.2
Locomotion velocity, session 21.21.42.5-1.21.31.3-0.81.0-0.9-0.91.2-1.61.61.4-0.7
Locomotion distance, session 20.70.91.41.1-1.0-1.21.0-0.80.91.0-0.80.9-0.8-1.10.6
Locomotion velocity, session 30.70.81.1-0.91.01.0-0.80.7-0.6-1.00.9-1.00.91.1-0.7
Locomotion distance, session 30.00.00.1-0.10.20.20.2-0.00.1-0.10.2-0.0-0.10.3-0.2
Stereotopy head waving bouts, day 31.61.94.41.2-1.5-1.30.6-0.60.61.2-1.01.7-1.8-2.11.9
Stereotopy head waving duration, day 30.81.02.21.1-1.1-1.00.7-0.60.60.8-1.01.2-1.2-1.51.2
Locomotion velocity, session 70.20.21.30.10.10.20.4-0.60.50.1-0.50.00.00.6-1.1
Locomotion distance, session 70.10.20.40.4-0.3-0.30.5-0.60.60.3-0.50.3-0.3-0.1-0.5
Stereotopy head waving bouts, day 70.50.62.80.4-0.6-0.70.20.1-0.10.6-0.30.7-0.7-1.21.7
Stereotopy head waving duration, day 70.40.50.90.6-0.7-0.80.5-0.30.30.9-0.60.8-0.8-0.90.9
Locomotion velocity, session 80.10.10.20.2-0.10.00.4-0.30.30.4-0.40.0-0.00.1-0.2
Locomotion distance, session 80.30.41.40.5-0.7-0.60.2-0.00.20.7-0.20.5-0.5-1.01.2
Degree of sensitization distance0.20.20.70.2-0.5-0.4-0.20.1-0.20.3-0.20.4-0.3-0.70.8
Degree of sensitization stereotypy0.40.51.7-0.60.50.3-0.71.1-0.9-0.30.7-0.40.4-0.21.3
Conditioned locomotion0.10.10.50.0-0.0-0.00.20.1-0.0-0.10.50.6-0.7-0.20.6
Cocaine response after cond. corrected2.03.16.3-2.01.61.9-2.51.9-2.1-1.22.4-1.41.41.10.2
Cocaine response after cond. not corrected0.30.51.6-0.60.30.4-1.30.8-0.9-0.11.10.0-0.1-0.20.8
Cocaine response before conditioning5.26.28.72.7-2.6-2.92.6-2.22.32.0-2.52.8-2.8-2.71.2
Saline control response0.20.30.8-0.30.30.3-0.70.8-0.6-0.30.9-0.30.3-0.30.9
Bone: connectivity density0.10.10.30.4-0.2-0.00.5-0.00.30.5-0.0-0.10.1-0.30.5
Bone: cortical apparent density0.00.10.30.10.10.20.20.00.2-0.2-0.0-0.50.60.1-0.2
Bone: cortical area5.18.211.13.2-3.2-3.32.6-2.72.73.0-2.33.3-3.2-3.11.0
Bone: cortical porosity2.22.33.51.5-1.7-1.91.4-1.21.11.7-1.21.8-1.8-1.71.1
Bone: cortical porosity3.23.55.12.0-2.1-2.32.0-1.81.82.1-1.82.0-1.9-1.70.4
Bone: cortical thickness2.64.37.72.2-2.4-2.51.6-1.51.62.2-1.32.3-2.2-2.81.6
Bone: cortical thickness3.84.77.52.3-2.5-2.31.9-1.61.62.4-1.62.5-2.3-2.71.7
Bone: cortical tissue density0.10.10.6-0.10.30.40.10.20.0-0.30.1-0.60.80.2-0.3
Condit. Reinf. active minus inactive responses2.42.73.61.8-1.9-1.61.9-1.61.61.4-1.51.9-1.9-1.70.7
Condit. Reinf. active-inactive response ratio0.60.61.30.8-0.9-0.70.7-0.60.60.4-0.41.2-1.1-0.90.5
Condit. Reinf. active responses3.14.07.02.3-2.0-1.82.6-2.42.41.9-2.31.8-1.8-1.3-0.5
Condit. Reinf. inactive responses2.53.26.11.9-1.4-1.32.3-2.42.32.0-2.50.8-0.8-0.4-1.8
Incentive salience index mean2.33.04.52.0-2.0-1.62.1-1.71.81.5-1.51.9-1.9-1.70.6
Condit. Reinf. lever presses0.30.40.70.8-0.8-0.20.8-0.70.80.4-0.20.8-0.8-0.70.2
Condit. Reinf. active minus inactive responses4.06.28.93.0-2.6-2.32.8-2.62.82.3-2.52.5-2.6-2.40.5
Condit. Reinf. active-inactive response ratio1.52.44.11.9-1.5-1.42.0-1.82.01.5-1.61.3-1.4-1.2-0.3
Condit. Reinf. active responses4.76.89.13.0-3.0-2.42.6-2.52.62.4-2.42.9-2.9-2.91.0
Condit. Reinf. inactive responses0.71.02.60.9-1.3-0.70.4-0.40.40.7-0.61.3-1.3-1.61.3
Condit. Reinf. lever presses6.08.711.53.4-3.4-3.13.2-2.93.13.0-3.03.0-2.9-2.90.7
Condit. Reinf. lever reinforcers received3.65.17.32.7-2.6-2.02.5-2.32.52.0-2.22.4-2.4-2.30.5
Conditioned reinforcement - actives0.83.04.71.7-2.2-1.81.4-1.31.21.9-1.61.9-1.9-2.11.4
Conditioned reinforcement - inactives0.20.51.20.6-1.0-0.80.6-0.70.40.7-0.61.1-1.0-0.70.4
Conditioned locomotion0.71.13.50.8-1.2-1.20.1-0.20.11.0-0.70.9-0.9-1.71.9
Patch foraging indifference point 0 sec0.10.40.9-0.60.10.2-0.90.9-0.9-0.10.7-0.60.5-0.20.8
Patch foraging indifference point AUC0.92.26.61.2-0.4-0.32.6-2.02.20.5-1.70.6-0.50.8-2.2
Delay disc. indifference point, 0s delay0.40.40.80.5-0.5-0.30.7-0.80.70.6-0.90.7-0.6-0.1-0.8
Delay disc. indifference point, 16s delay0.10.21.2-0.2-0.3-0.0-0.00.3-0.40.10.20.3-0.3-0.31.1
Delay disc. indifference point, 2s delay0.50.53.2-0.20.50.70.4-0.40.4-0.4-0.2-0.40.41.2-1.8
Delay disc. indifference point, 24s delay0.10.10.6-0.20.30.20.10.3-0.2-0.30.20.1-0.00.10.8
Delay disc. indifference point, 4s delay0.50.51.5-0.70.81.2-0.70.8-0.6-0.80.8-0.60.60.60.2
Delay disc. indifference point, 8s delay0.20.42.2-0.4-0.10.4-0.40.8-0.7-0.10.9-0.10.2-0.41.5
Indifference point function ln k0.10.31.3-0.50.10.0-1.10.6-0.7-0.20.5-0.2-0.0-0.20.5
Indifference point function log k0.10.31.3-0.50.10.0-1.10.6-0.7-0.20.5-0.2-0.0-0.20.5
Patch foraging total patch changes 0 sec0.30.91.9-1.00.50.7-1.41.3-1.3-0.51.2-1.00.90.10.7
Patch foraging total patch changes 12 sec1.21.73.11.4-1.4-1.21.8-1.51.51.5-1.31.1-1.1-0.8-0.4
Patch foraging total patch changes 18 sec0.61.43.81.2-1.3-0.71.9-1.51.40.9-1.30.9-0.9-0.4-0.7
Patch foraging total patch changes 24 sec0.51.72.91.5-1.7-1.21.5-1.11.21.6-1.01.2-1.1-1.51.0
Patch foraging total patch changes 6 sec0.10.20.6-0.50.50.6-0.00.4-0.4-0.30.5-0.80.70.6-0.2
Patch foraging time to switch 0 sec0.20.72.1-0.7-0.00.2-1.41.0-1.30.10.60.3-0.5-0.71.5
Patch foraging water rate 0 sec0.83.24.62.0-2.1-1.92.1-1.81.91.7-1.61.8-1.7-1.70.5
Patch foraging water rate 12 sec0.51.92.91.6-1.5-1.61.7-1.71.71.4-1.50.9-0.9-0.9-0.6
Patch foraging water rate 18 sec1.12.43.81.9-1.8-1.91.9-1.61.81.7-1.50.9-1.0-1.40.0
Patch foraging water rate 24 sec0.60.92.21.1-1.0-1.11.5-1.01.21.0-1.10.1-0.1-0.5-0.3
Patch foraging water rate 6 sec1.42.13.21.7-1.8-1.31.7-1.71.71.2-1.61.3-1.2-1.20.1
Seeking ratio, delayed vs. immediate footshock0.50.71.80.8-0.9-1.30.6-0.60.51.0-0.60.6-0.7-0.90.6
Distance traveled before self-admin2.14.66.82.1-2.6-2.61.8-1.71.62.6-2.42.1-2.1-2.41.1
Distance traveled after self-admin1.83.24.61.9-1.9-2.11.5-2.11.81.7-1.91.9-2.0-1.3-0.6
Extensor digitorum longus weight0.41.62.51.4-1.3-1.61.2-1.51.41.6-1.51.0-1.0-0.8-0.6
Bone: elastic displacement1.11.42.6-1.21.11.1-1.61.4-1.3-1.41.5-1.00.90.50.4
Bone: elastic work0.30.40.9-0.50.60.4-0.90.7-0.5-0.50.7-0.70.70.3-0.2
Bone: endosteal estimation1.12.64.41.7-1.5-1.72.1-2.01.91.6-1.81.4-1.5-0.7-0.8
Bone: endosteal perimeter2.04.88.42.4-1.9-2.22.7-2.92.81.7-2.41.9-2.0-0.9-1.5
Epididymis fat weight5.929.739.3-6.15.66.1-6.26.1-6.0-5.26.3-5.25.24.30.7
Delta time in closed arm before/after self-admin0.90.91.6-1.00.91.2-1.31.2-1.2-1.01.1-0.30.30.20.8
Delta time in open arm before/after self-admin0.40.40.90.6-0.7-0.50.8-0.90.90.6-0.70.2-0.2-0.0-1.0
Diff in mean of infusions in LGA sessions6.511.716.7-3.83.43.6-4.04.1-4.1-3.63.8-3.03.12.11.4
Delay discount exponential model param0.20.20.50.5-0.3-0.70.3-0.60.60.4-0.60.3-0.3-0.2-0.7
Extinction: sum of active levers before priming0.10.10.50.2-0.5-0.6-0.1-0.20.10.7-0.30.1-0.2-0.4-0.1
Active lever presses in extinction session 60.60.61.80.3-0.7-0.7-0.40.1-0.20.7-0.00.7-0.9-1.31.4
Bone: final force3.86.28.62.7-2.5-2.82.9-2.92.82.5-2.52.5-2.4-1.7-0.5
Bone: final moment3.55.67.72.6-2.4-2.72.8-2.82.72.4-2.42.3-2.3-1.5-0.7
Food consumed during 24 hour testing period0.71.32.01.3-1.4-1.31.2-1.01.00.9-0.91.4-1.2-1.40.7
Glucose0.30.51.00.8-0.6-0.80.7-1.00.80.2-0.70.9-0.9-0.4-0.5
Heart weight0.00.00.1-0.0-0.10.40.2-0.0-0.0-0.1-0.3-0.0-0.10.00.0
Delay discount hyperbolic model param0.20.20.50.5-0.3-0.70.2-0.50.40.4-0.50.4-0.4-0.4-0.3
Intermittent access intake day 1-15 change0.73.95.92.0-2.0-1.82.3-2.42.22.1-2.41.8-1.6-0.9-1.4
Intermittent access intake escalation0.63.35.31.9-1.8-1.72.2-2.32.11.9-2.31.6-1.4-0.7-1.6
Intermittent access intake escalation 21.01.74.81.2-1.0-1.01.5-1.81.61.1-1.60.7-0.60.1-2.2
Intermitt. access day 1 inactive lever presses0.10.92.0-1.10.71.2-1.21.0-1.2-1.01.4-0.30.30.60.5
Intermitt. access day 15 inactive lever presses0.00.20.60.4-0.4-0.40.3-0.50.40.5-0.10.8-0.8-0.2-0.2
Intermitt. access escalation Index0.30.82.0-0.81.41.4-0.50.7-0.5-1.01.0-0.50.71.0-0.5
Intermittent access day 1 total infusions0.10.32.00.1-0.6-0.5-0.40.2-0.30.60.00.1-0.3-0.81.4
Intermittent access day 15 total infusions1.02.33.81.5-1.8-2.01.4-1.41.21.9-1.71.4-1.4-1.50.7
Intermittent access terminal intake (last 3 days)1.22.03.21.5-1.8-1.81.3-1.41.31.8-1.51.2-1.2-1.40.4
Intermittent access total infusions1.21.52.71.2-1.5-1.60.9-0.90.81.6-1.21.0-1.0-1.41.2
Intermittent access day 1 locomotion0.50.93.8-0.70.30.1-1.41.3-1.3-0.40.7-0.70.6-0.62.0
Intermittent access day 15 total locomotion0.51.93.41.5-1.5-1.81.0-1.51.41.6-1.91.1-1.1-1.2-0.2
Intermittent access total locomotion0.50.61.30.8-1.0-1.00.0-0.50.41.0-0.80.6-0.7-1.10.8
Intermittent access standard deviation0.94.67.72.2-2.8-2.82.0-2.42.12.6-2.61.7-1.6-1.5-0.7
Left kidney weight0.64.67.42.4-2.3-1.92.1-2.72.62.2-2.22.3-2.2-1.3-1.0
Right kidney weight1.17.912.63.0-3.0-2.32.6-3.63.32.9-3.23.0-3.0-1.6-1.6
Cocaine induced anxiety1.33.75.9-1.81.81.9-2.02.4-2.0-2.02.2-2.02.00.81.7
Post-drug Anxiety0.10.10.60.2-0.2-0.4-0.10.00.00.0-0.20.4-0.4-0.40.8
Baseline Anxiety4.06.89.42.6-2.6-2.82.3-3.02.52.7-3.03.1-3.0-1.8-0.9
Tail length1.47.510.13.0-2.9-2.73.0-2.92.83.0-2.43.2-3.1-2.30.5
Length with tail1.66.911.02.8-2.9-2.62.1-2.32.33.0-1.83.3-3.2-3.01.5
Length without tail0.84.47.42.3-2.4-2.31.3-1.61.72.5-1.52.4-2.3-2.71.4
Times rat made contact with spout2.12.54.6-1.61.21.3-1.72.0-1.9-1.82.2-1.51.50.61.0
Lifetime Intake1.61.93.41.2-1.7-1.80.8-0.70.71.7-1.11.2-1.2-1.81.8
Liver weight, left1.01.72.81.4-1.6-1.60.7-1.00.91.6-1.21.3-1.3-1.70.8
Liver weight, right0.30.51.20.7-0.9-0.80.0-0.70.50.6-0.51.1-1.0-0.80.1
Locomotor activity2.54.05.62.4-2.0-2.32.3-2.12.21.8-2.41.7-1.6-2.00.3
Locomotor testing distance2.97.110.53.1-2.6-2.73.2-3.13.22.4-3.22.3-2.3-2.0-0.8
Locomotor testing rearing2.59.214.43.4-2.9-2.93.6-3.83.72.6-3.52.8-2.8-1.9-1.7
Locomotion in novel chamber0.30.42.3-0.0-0.3-0.7-0.20.4-0.50.30.00.2-0.6-0.91.5
Locomotion in novel chamber post-restriction0.10.42.60.3-0.5-0.20.10.5-0.30.00.2-0.00.0-1.21.6
Fecal boli incidents, locomotor time 10.61.73.0-1.31.61.4-1.01.0-1.0-1.50.9-1.71.51.6-0.7
Change in fecal boli incidents, locomotor task1.41.52.61.2-1.5-1.60.9-0.90.91.3-1.11.4-1.2-1.40.9
Time >=10cm from walls, locomotor time 10.50.71.30.7-1.1-1.00.8-0.30.41.0-0.80.5-0.7-1.11.0
Bouts of movement, locomotor time 15.57.211.9-2.82.52.6-3.03.5-3.2-2.52.8-2.72.71.21.9
Total resting periods, locomotor time 16.07.011.4-2.82.52.6-2.93.4-3.1-2.62.8-2.72.71.31.7
Rest time, locomotor task time 12.33.74.7-2.12.02.0-2.02.1-2.0-2.12.1-2.22.01.60.1
Distance moved, locomotor task time 11.54.25.32.1-2.2-2.22.1-2.32.22.2-2.22.3-2.1-1.5-0.8
Vertical activity count, locomotor time 10.10.40.80.6-0.7-0.40.7-0.80.80.6-0.90.6-0.4-0.1-0.9
Time >=10cm from walls, locomotor time 20.71.93.91.6-2.0-1.51.3-1.51.51.4-1.51.0-1.2-1.2-0.2
Bouts of movement, locomotor time 21.85.99.4-2.92.42.4-3.03.0-3.1-2.72.7-1.71.71.51.2
Total resting periods, locomotor time 21.97.611.5-3.22.82.6-3.33.3-3.4-3.03.0-2.22.11.81.1
Rest time, locomotor task time 21.22.13.2-1.71.61.4-1.51.8-1.7-1.31.7-1.51.31.00.5
Distance moved, locomotor task time 22.43.14.22.1-2.0-1.81.7-1.92.01.9-1.81.7-1.7-1.6-0.5
Vertical activity count, locomotor time 20.20.43.1-0.10.20.50.1-0.40.3-0.5-0.0-0.30.40.9-1.8
Light reinforcement 10.00.00.20.10.10.00.0-0.10.3-0.20.10.00.10.2-0.5
Light reinforcement 20.40.81.9-0.61.41.2-0.10.5-0.1-1.40.9-0.70.81.2-0.9
Bone: marrow area1.12.74.51.7-1.5-1.72.1-2.02.01.7-1.81.4-1.5-0.7-0.8
Bone: maximum diameter2.75.57.62.6-2.5-2.82.2-2.32.32.6-1.92.5-2.6-2.40.6
Bone: maximum force3.46.68.92.9-2.6-2.82.9-3.02.92.7-2.52.7-2.6-1.8-0.6
Bone: maximum moment3.36.38.82.8-2.5-2.72.8-3.02.92.6-2.52.5-2.5-1.7-0.8
Mean time between licks in bursts0.32.03.91.5-1.1-1.21.3-1.81.81.5-2.01.2-1.0-0.4-1.2
Mean num. licks in bursts0.20.51.8-0.70.60.2-1.10.8-0.9-0.51.3-0.40.30.10.5
Cd content in liver0.40.40.6-0.80.50.8-0.50.7-0.8-0.40.6-0.80.70.60.1
Co content in liver1.61.93.91.3-1.5-1.51.2-1.11.01.2-0.91.9-2.0-1.50.9
Cu content in liver0.30.41.20.20.3-0.10.8-0.60.70.0-0.8-0.20.30.8-1.1
Fe content in liver0.40.51.2-0.70.90.9-0.50.5-0.4-0.70.3-0.80.81.1-0.7
K content in liver1.21.22.71.0-0.5-0.61.1-1.61.60.6-1.31.0-0.90.3-1.6
Mg content in liver1.41.54.11.1-0.6-0.91.1-1.81.70.8-1.50.7-0.60.3-2.0
Mn content in liver4.14.68.02.5-1.8-2.12.5-2.72.81.8-2.81.7-1.7-1.2-1.0
Na content in liver4.55.07.32.7-2.1-2.42.0-2.52.72.1-2.62.3-2.3-1.8-0.2
Rb content in liver1.51.72.31.5-1.5-1.01.5-1.51.41.3-1.21.4-1.4-1.10.1
Se content in liver0.50.61.0-1.00.81.0-0.91.0-1.0-0.70.5-0.60.60.70.2
Sr content in liver0.30.30.40.6-0.6-0.50.7-0.50.50.5-0.50.5-0.6-0.60.2
Zn content in liver0.50.53.10.0-0.5-0.4-0.30.5-0.50.60.30.6-0.6-1.01.8
Bone: minimum diameter1.42.63.71.9-1.6-1.81.7-1.91.91.6-1.61.6-1.6-1.2-0.5
Time in familiar zone, hab. session 10.50.51.40.7-0.5-0.41.2-1.00.90.6-1.00.6-0.5-0.1-0.4
Time in novel zone, hab. session 11.11.32.4-1.21.21.0-1.61.2-1.2-0.91.2-1.31.20.9-0.3
Total zone transitions, hab. session 11.92.74.22.0-1.8-1.81.9-1.41.81.7-1.51.3-1.3-1.90.8
Total locomotion distance, hab. session 12.13.05.42.1-1.5-1.72.3-2.02.31.5-2.01.3-1.2-1.2-0.6
Locomotion velocity, hab. session 11.72.54.41.9-1.4-1.62.1-1.92.11.3-1.81.1-1.1-1.0-0.6
Time in familiar zone, hab. session 21.31.42.1-1.11.21.2-1.41.4-1.2-1.31.3-1.31.50.70.2
Time in novel zone, hab. session 20.91.01.90.8-1.2-1.01.0-1.00.71.4-1.11.1-1.2-0.80.2
Total zone transitions, hab. session 21.62.03.91.6-1.6-1.71.3-0.91.11.4-1.11.2-1.1-2.01.5
Total locomotion distance, hab. session 20.20.30.50.7-0.6-0.70.6-0.40.50.2-0.70.4-0.3-0.70.5
Locomotion velocity, hab. session 20.20.30.70.7-0.5-0.70.6-0.50.60.2-0.80.4-0.3-0.60.2
Novel to familiar place preference ratio0.60.84.8-0.2-0.4-0.0-0.91.0-1.00.40.40.4-0.3-1.22.2
Novelty place preference0.60.84.6-0.4-0.20.0-1.01.1-1.10.20.40.1-0.1-1.12.2
Time in novel zone, NPP test0.70.84.5-0.4-0.3-0.0-1.01.1-1.10.20.30.00.0-1.12.1
Total zone transitions, NPP test0.50.71.80.9-0.9-1.10.9-0.20.50.6-0.60.5-0.4-1.21.3
Total locomotion distance, NPP test0.81.11.81.2-1.0-1.31.4-0.91.20.6-1.30.8-0.8-1.00.4
Locomotion velocity, NPP test0.91.32.01.3-1.0-1.31.4-1.11.30.6-1.41.1-1.1-1.00.3
Intraocular pressure0.61.02.31.1-1.0-1.31.1-0.90.91.5-1.00.4-0.6-1.00.2
Delta distance traveled before/after self-admin0.80.92.8-0.81.10.9-0.60.1-0.2-1.31.0-0.50.41.5-1.7
Delta ambulatory time before/after self-admin0.30.52.50.6-0.2-0.50.6-1.11.0-0.1-0.20.5-0.50.4-1.6
Parametrial fat weight2.56.08.4-2.52.62.6-2.62.2-2.1-2.92.0-2.82.82.6-1.1
Pavlov. Cond. lever latency0.91.14.9-0.71.10.5-0.3-0.1-0.0-0.3-0.3-1.21.21.7-2.2
Pavlov. Cond. magazine entry latency0.10.20.40.2-0.6-0.10.1-0.1-0.00.30.10.5-0.5-0.60.7
Pavlov. Cond. change in total contacts0.80.81.90.9-1.2-0.50.9-0.70.70.5-0.21.2-1.4-1.00.9
Pavlov. Cond. index score0.81.01.90.9-1.3-0.60.7-0.60.50.7-0.11.3-1.4-1.41.2
Pavlov. Cond. latency score1.01.33.21.0-1.4-0.80.6-0.40.40.80.11.4-1.5-1.71.8
Pavlov. Cond. lever contacts1.21.44.11.1-1.5-0.80.7-0.30.50.60.01.4-1.5-1.92.0
Pavlov. Cond. magazine entry number0.10.10.4-0.40.60.0-0.50.5-0.3-0.30.1-0.50.50.2-0.1
Pavlov. Cond. intertrial magazine entries2.32.83.91.8-1.6-1.71.9-2.01.91.9-2.01.6-1.5-1.0-0.6
Pavlov. Cond. lever-magazine prob. diff.0.70.91.90.9-1.3-0.60.7-0.60.50.7-0.11.3-1.4-1.31.2
Pavlov. Cond. response bias0.10.20.40.4-0.70.00.4-0.40.30.10.00.6-0.6-0.40.3
Pavlov. Cond. lever latency4.46.29.8-2.73.12.9-2.52.1-2.2-2.72.3-2.42.32.8-1.4
Pavlov. Cond. magazine entry latency1.01.47.40.5-1.4-0.80.00.3-0.40.60.31.3-1.2-1.92.7
Pavlov. Cond. change in total contacts1.43.54.82.1-2.2-2.02.2-1.81.91.8-2.01.8-1.6-1.80.7
Pavlov. Cond. index score1.93.05.61.7-2.3-1.91.3-1.01.01.7-1.01.9-1.8-2.42.1
Pavlov. Cond. latency score1.42.24.61.3-2.0-1.71.0-0.70.71.3-0.71.7-1.6-2.12.1
Pavlov. Cond. lever contacts4.46.510.02.8-3.2-3.02.6-2.12.22.7-2.42.5-2.4-2.91.5
Pavlov. Cond. magazine entry number0.81.05.6-0.41.10.7-0.1-0.30.3-0.3-0.3-1.00.91.5-2.4
Pavlov. Cond. intertrial magazine entries0.51.02.91.0-0.3-0.61.0-1.41.40.8-1.00.8-0.80.1-1.7
Pavlov. Cond. lever-magazine prob. diff.1.52.34.31.4-2.0-1.61.1-0.80.81.4-0.91.7-1.6-2.11.9
Pavlov. Cond. response bias4.05.59.02.4-3.0-2.62.1-1.71.82.5-1.92.5-2.3-2.91.9
Time in closed arm before self-admin0.00.00.10.1-0.2-0.30.1-0.10.10.2-0.20.0-0.0-0.10.2
Time in closed arm after self-admin0.00.00.10.00.10.1-0.20.1-0.1-0.20.10.3-0.3-0.20.3
Time in open arm before self-admin1.01.21.9-1.11.11.0-1.11.4-1.3-0.91.3-1.01.00.51.0
Time in open arm after self-admin0.10.10.3-0.3-0.00.2-0.40.4-0.40.10.4-0.50.50.00.2
Bone: periosteal estimation3.17.39.53.0-2.9-3.12.9-2.92.82.9-2.52.8-2.9-2.30.0
Bone: periosteal perimeter3.97.710.23.1-2.8-3.02.9-3.23.12.7-2.72.9-3.0-2.2-0.5
Bone: post-yield work1.01.73.11.4-1.1-0.91.4-1.81.71.1-1.41.2-1.3-0.5-1.1
Progressive ratio test 1 active lever presses1.42.55.31.3-1.9-1.80.9-0.70.61.7-1.11.6-1.5-2.32.3
Progressive ratio test 1 breakpoint1.42.45.01.3-1.9-1.70.9-0.70.61.7-1.11.5-1.5-2.22.2
Progressive ratio test 1 inactive lever presses0.41.03.60.7-1.2-0.70.3-0.10.20.9-0.31.0-1.0-1.51.9
Progressive ratio test 2 active lever presses2.02.84.21.8-2.1-2.01.8-1.51.51.8-1.71.5-1.4-1.71.0
Progressive ratio test 2 breakpoint2.32.94.41.9-2.1-2.01.9-1.61.61.9-1.81.6-1.4-1.70.9
Progressive ratio test 2 inactive lever presses0.51.62.41.3-1.4-1.61.4-1.11.11.4-1.11.2-1.1-1.41.2
Incentive Sensitization - Responses0.51.42.01.3-1.3-1.11.4-1.21.31.2-1.21.2-1.1-1.00.5
Incentive Sensitization - Breakpoint0.61.32.11.3-1.2-1.11.5-1.31.31.1-1.21.2-1.0-0.80.2
Sum of active levers in priming session hrs 5-62.72.64.1-2.01.61.7-2.01.7-1.9-1.31.9-1.41.31.4-0.2
Progressive ratio0.41.24.60.6-1.3-0.9-0.00.1-0.20.80.01.2-1.2-1.92.1
Food seeking constrained by brief footshock0.40.41.0-0.70.80.8-0.70.7-0.7-1.00.8-0.10.20.50.4
Seeking ratio, punishment vs. effort0.30.61.8-0.61.10.8-0.30.1-0.1-0.90.4-0.60.61.3-1.2
Retroperitoneal fat weight2.410.917.3-3.53.44.2-4.13.4-3.2-3.43.5-3.13.12.9-0.4
Reaction time number correct0.10.20.50.4-0.4-0.40.2-0.60.50.1-0.70.3-0.2-0.2-0.7
Reaction time mean minus median0.21.32.8-1.21.21.7-0.51.1-0.9-1.20.9-1.51.31.4-0.1
Reaction time mean minus median AUC0.53.45.4-1.92.02.3-1.31.7-1.5-2.01.7-2.22.22.1-0.4
Reaction time num false alarms2.74.68.92.4-1.9-1.93.0-2.92.91.8-2.21.6-1.6-0.8-1.8
Reaction time num false alarms AUC2.35.29.62.6-2.2-2.13.1-2.92.92.0-2.41.8-1.9-1.1-1.4
Reaction time trials correct on left0.10.20.50.4-0.4-0.40.2-0.60.50.1-0.70.3-0.2-0.2-0.7
Reaction time trials on left0.10.20.60.5-0.4-0.40.3-0.60.60.1-0.80.3-0.2-0.2-0.8
Reaction time mean1.63.55.6-2.02.12.3-0.91.6-1.4-1.91.8-2.42.32.3-0.6
Reaction time mean AUC2.04.86.9-2.42.52.6-1.52.0-1.9-2.42.1-2.62.52.5-0.5
Median of all reaction times2.13.25.1-1.92.02.1-0.91.5-1.4-1.81.8-2.32.32.2-0.6
Reaction time omissions0.60.92.4-0.91.11.6-0.30.5-0.4-0.70.6-1.01.01.5-1.1
Reaction time false alarm rate2.33.26.52.0-1.7-1.62.5-2.22.31.7-1.71.5-1.5-0.9-0.9
Reaction time premature initiation rate0.10.10.50.2-0.2-0.10.40.10.10.20.00.0-0.1-0.40.7
Reaction time premature initiations0.00.10.20.4-0.3-0.20.5-0.30.40.2-0.30.2-0.3-0.40.2
Std. dev. reaction times0.41.42.6-1.21.31.6-0.30.9-0.7-1.10.8-1.61.41.6-0.5
Reaction time trials completed0.10.20.60.5-0.4-0.40.3-0.60.60.1-0.80.3-0.2-0.2-0.8
Reaction time trials AUC0.10.40.90.7-0.6-0.60.5-0.80.80.3-0.90.4-0.4-0.3-0.8
Run reversals in cocaine runway, females0.10.10.30.30.2-0.1-0.1-0.20.30.4-0.6-0.10.2-0.2-0.3
Run reversals in cocaine runway, males0.91.01.7-0.81.21.3-0.70.8-0.6-1.01.2-1.21.21.0-0.4
Latency to leave start box in cocaine runway0.10.10.2-0.10.20.1-0.30.3-0.1-0.30.2-0.40.5-0.10.4
Latency to leave start box in cocaine runway, F0.30.40.90.8-0.6-0.60.3-0.30.50.6-0.40.4-0.3-1.00.8
Latency to leave start box in cocaine runway, M2.12.02.8-1.51.61.4-1.21.3-1.2-1.71.2-1.71.71.5-0.6
Std. dev. time between licks in bursts1.22.34.11.6-1.6-1.61.3-1.71.62.0-2.01.4-1.2-1.1-0.2
Total sessions with >9 infusions2.12.611.11.1-1.8-1.60.6-0.10.11.6-0.81.2-1.2-2.63.3
Short access day 1 total inactive lever presses0.20.43.2-0.1-0.1-0.1-0.30.6-0.60.00.50.3-0.5-0.81.8
Short access day 10 total inactive lever presses0.10.81.7-1.01.01.3-1.10.5-0.6-0.80.8-0.30.31.3-0.9
Short access day 1 total infusions0.51.16.90.5-1.0-0.90.10.3-0.30.8-0.20.4-0.4-1.62.6
Short access day 10 total infusions1.62.75.61.5-2.0-1.80.7-0.80.71.9-1.41.7-1.7-2.42.0
Short access total infusions0.91.26.00.6-1.2-1.20.10.1-0.21.1-0.50.6-0.7-1.82.4
Short access day 1 locomotion0.30.52.30.3-0.8-0.4-0.30.2-0.30.7-0.40.2-0.2-1.21.5
Short access day 10 total locomotion0.10.62.2-0.60.30.2-1.21.0-1.0-0.30.7-0.10.1-0.51.5
Short access total locomotion0.60.95.80.2-0.6-0.7-0.60.5-0.60.7-0.10.5-0.5-1.62.4
One hour access (0.3 mA shock)2.93.55.02.1-2.0-2.21.6-1.91.82.2-2.01.8-1.7-1.80.6
Compulsive drug intake2.13.05.2-2.12.02.0-2.31.7-1.9-1.91.7-1.11.21.6-0.3
One hour access (shock baseline)1.53.85.62.3-2.3-2.42.0-1.81.92.3-2.01.5-1.5-2.10.9
Social response proportion1.51.93.1-1.71.51.8-1.31.4-1.5-1.51.6-0.90.91.4-0.0
Social responses2.83.76.62.0-2.1-1.52.2-2.12.02.0-1.82.6-2.2-1.40.2
Social time0.10.10.4-0.30.50.60.30.1-0.1-0.50.10.2-0.10.40.2
Soleus weight0.10.30.50.5-0.4-0.60.2-0.70.60.5-0.70.5-0.4-0.2-0.7
Bone: stiffness4.88.811.23.2-3.1-3.23.3-3.33.13.0-2.83.3-3.2-2.3-0.1
Tibialis anterior weight0.10.41.6-0.60.2-0.1-0.90.9-1.0-0.30.4-0.30.2-0.21.2
Time to tail flick, vehicle, before self-admin0.30.31.0-0.60.70.7-0.70.5-0.7-0.61.00.4-0.30.20.3
Time to tail flick, vehicle, after self-admin3.26.59.2-2.92.62.5-2.52.2-2.3-2.72.3-2.82.83.0-1.6
Time to tail flick, test, before self-admin1.31.52.7-1.11.61.3-1.10.9-0.8-1.61.4-1.21.11.4-0.9
Time to tail flick, test, after self-admin0.20.20.6-0.50.50.6-0.70.5-0.5-0.80.4-0.20.10.30.0
Delta time to tail flick, vehicle, before/after SA1.31.43.4-0.90.90.8-0.50.4-0.4-0.90.2-1.81.71.8-1.8
Delta time to tail flick, test, before/after SA0.10.10.70.0-0.4-0.1-0.00.2-0.20.1-0.10.1-0.1-0.40.8
Tibia length7.420.726.65.2-5.0-4.94.5-4.24.44.9-3.55.1-5.1-5.01.6
Ambulatory time before self-admin1.95.79.32.4-2.8-2.82.2-2.01.93.0-2.72.2-2.2-2.50.9
Ambulatory time after self-admin2.13.34.51.8-2.0-2.11.7-2.11.81.8-1.82.1-2.1-1.2-0.6
Bone: tissue strength0.50.61.10.8-0.4-0.71.0-1.01.10.6-1.00.6-0.4-0.1-0.8
Total heroin consumption1.01.23.1-1.30.50.6-1.41.5-1.8-0.51.2-0.70.6-0.01.4
Bone: trabecular number0.10.10.7-0.10.10.40.00.5-0.3-0.10.4-0.40.4-0.20.9
Bone: trabecular spacing0.10.20.60.0-0.3-0.2-0.50.1-0.30.30.40.7-0.6-0.60.7
Bone: trabecular thickness0.40.61.30.8-0.7-0.41.2-1.01.00.9-0.90.3-0.20.0-0.8
Bone: trabecular tissue density1.42.43.71.7-1.6-1.91.9-1.71.81.9-1.61.2-1.1-1.1-0.2
Water consumed over 24 hours1.01.94.41.2-1.7-1.60.6-0.60.51.0-0.61.8-1.8-2.11.6
Number of responses in last shaping day0.40.54.80.1-0.2-0.40.00.5-0.40.20.20.10.1-1.02.2