Hub : Genes

Fgf22

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Fgf22	0.06	0.04	2.8e-06	0.05	0.05	0.05	0.05	6.4e-07	1.0e-06	8.2e-07	1.3e-06
2	Brain	gene expression	Fgf22	0.09	0.06	7.8e-05	0.04	0.03	0.03	0.04	1.6e-04	3.4e-04	4.0e-04	3.0e-04
3	PL	gene expression	Fgf22	0.07	0.06	4.4e-07	0.07	0.06	0.06	0.06	5.5e-08	1.1e-06	5.3e-07	7.6e-07
4	BLA	gene expression	Fgf22	0.21	0.13	2.7e-06	0.14	0.1	0.11	0.11	9.1e-08	5.3e-06	2.7e-06	1.2e-06
5	LHb	gene expression	Fgf22	0.15	0.11	1.3e-03	0.08	0.09	0.06	0.07	5.2e-03	3.9e-03	1.8e-02	7.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.1	0.9	1.0	0.8	0.8	0.5
Area under the delay curve	2.4	2.6	2.8	-1.7	-1.5	-1.6	-1.6	1.7
BMI with tail	7.1	23.0	23.8	-4.8	-4.9	-4.9	-4.7	4.8
BMI without tail	3.4	7.1	8.4	-2.7	-2.6	-2.9	-2.9	2.1
Body weight	1.3	5.6	5.9	-2.3	-2.4	-2.4	-2.4	2.3
Weight adjusted by age	1.3	1.4	1.7	-1.3	-1.3	-1.3	-1.3	0.7
Bone surface	1.6	2.8	4.1	1.9	2.0	1.7	1.9	-0.1
Bone volume	1.4	2.3	3.5	1.7	1.9	1.6	1.7	0.1
Breakpoint value in progressive ratio session	4.5	5.0	6.7	2.1	2.1	2.2	2.1	-2.6
Number of licking bursts	0.4	0.5	0.7	-0.8	-0.9	-0.7	-0.7	0.1
Context. condit. distance diff. score	0.2	0.2	0.5	-0.4	-0.3	-0.6	-0.7	0.2
Locomotion velocity, session 1	1.1	1.2	1.7	1.0	1.2	1.3	1.2	-0.6
Locomotion distance, session 1	1.7	2.1	3.3	1.8	1.8	1.4	1.4	-0.6
Locomotion velocity, session 2	7.9	9.2	10.9	3.3	3.3	3.1	3.0	-2.4
Locomotion distance, session 2	3.8	5.3	6.6	2.5	2.4	2.4	2.6	-1.3
Locomotion velocity, session 3	6.1	7.1	9.4	2.6	2.5	2.5	2.5	-3.1
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	-0.2	-0.2	-0.2	-0.2
Stereotopy head waving bouts, day 3	7.0	8.3	9.0	3.0	2.8	2.8	2.9	-2.8
Stereotopy head waving duration, day 3	7.2	8.7	9.0	2.9	2.9	3.0	2.9	-3.0
Locomotion velocity, session 7	0.6	0.6	1.2	1.0	0.8	0.6	0.3	-1.1
Locomotion distance, session 7	0.5	0.6	1.1	-0.8	-0.8	-0.9	-1.0	0.3
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	0.9	0.7	0.6	0.7	-0.2
Stereotopy head waving duration, day 7	0.8	0.9	1.2	1.1	1.0	1.0	1.1	-0.5
Locomotion velocity, session 8	2.1	2.5	3.4	1.9	1.7	1.6	1.6	-1.1
Locomotion distance, session 8	0.7	1.0	1.4	1.1	1.2	0.9	0.9	-0.7
Degree of sensitization distance	0.3	0.3	0.5	-0.5	-0.4	-0.6	-0.7	0.6
Degree of sensitization stereotypy	1.2	1.3	2.2	-0.9	-1.0	-1.1	-1.0	1.5
Conditioned locomotion	2.6	3.0	3.7	-1.7	-1.9	-1.8	-1.9	1.2
Cocaine response after cond. corrected	8.9	9.9	11.8	-3.4	-3.3	-3.2	-3.3	2.5
Cocaine response after cond. not corrected	9.3	10.3	11.6	-3.4	-3.3	-3.3	-3.4	2.5
Cocaine response before conditioning	0.7	0.8	1.2	1.1	0.9	0.6	0.8	-0.9
Saline control response	0.1	0.1	0.2	-0.3	-0.5	-0.4	-0.3	0.3
Bone: connectivity density	0.1	0.2	0.6	0.4	0.5	0.3	0.3	0.8
Bone: cortical apparent density	1.1	1.5	2.3	-1.5	-1.2	-1.0	-1.0	1.3
Bone: cortical area	0.2	0.4	0.9	-0.4	-0.4	-0.6	-0.6	1.0
Bone: cortical porosity	0.8	0.9	1.3	1.1	1.0	1.0	1.0	-0.6
Bone: cortical porosity	0.4	0.5	0.8	0.9	0.7	0.7	0.7	-0.1
Bone: cortical thickness	0.8	1.4	2.3	-1.0	-1.1	-1.1	-1.1	1.5
Bone: cortical thickness	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.1
Bone: cortical tissue density	0.8	1.1	1.8	-1.4	-1.1	-0.8	-0.8	1.1
Condit. Reinf. active minus inactive responses	5.1	5.7	6.4	2.4	2.4	2.3	2.3	-2.5
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.5	0.9	1.1	1.3	1.2	-1.6
Condit. Reinf. active responses	5.9	7.3	8.6	2.9	2.8	2.7	2.7	-2.4
Condit. Reinf. inactive responses	2.5	3.0	4.5	2.1	1.8	1.8	1.8	-1.0
Incentive salience index mean	4.0	4.9	6.1	2.5	2.3	2.2	2.1	-2.0
Condit. Reinf. lever presses	0.9	1.2	2.2	1.5	1.2	1.1	1.1	-0.1
Condit. Reinf. active minus inactive responses	0.8	1.0	2.2	0.8	0.7	0.8	1.0	-1.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.8	-0.8	-0.5	-0.3	0.1
Condit. Reinf. active responses	1.0	1.4	2.5	1.0	0.9	1.0	1.2	-1.6
Condit. Reinf. inactive responses	0.9	1.1	1.8	1.0	1.0	0.8	0.9	-1.3
Condit. Reinf. lever presses	1.2	1.7	2.9	1.2	1.1	1.2	1.2	-1.7
Condit. Reinf. lever reinforcers received	0.5	0.7	1.8	0.6	0.5	0.7	0.8	-1.3
Conditioned reinforcement - actives	2.2	2.2	2.6	1.6	1.5	1.5	1.4	-1.4
Conditioned reinforcement - inactives	0.6	0.7	1.1	-0.8	-0.8	-0.8	-1.1	0.6
Conditioned locomotion	7.1	8.5	8.9	3.0	2.9	2.9	2.8	-2.9
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.3	-0.4	-0.3	-0.3	0.6
Patch foraging indifference point AUC	0.6	0.7	0.8	0.8	0.8	0.8	0.9	-0.9
Delay disc. indifference point, 0s delay	3.7	4.0	8.7	-1.7	-1.7	-1.7	-1.7	2.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.5	-0.4	-0.3	-0.3	0.4
Delay disc. indifference point, 2s delay	4.4	4.9	6.7	-2.0	-2.0	-2.2	-2.1	2.6
Delay disc. indifference point, 24s delay	1.3	1.3	1.6	-1.3	-1.2	-1.0	-1.1	1.0
Delay disc. indifference point, 4s delay	0.7	0.7	1.0	-0.8	-0.7	-0.8	-0.8	1.0
Delay disc. indifference point, 8s delay	2.1	2.2	2.6	-1.5	-1.4	-1.6	-1.6	1.2
Indifference point function ln k	0.4	0.5	0.7	-0.8	-0.8	-0.7	-0.8	0.6
Indifference point function log k	0.4	0.5	0.7	-0.8	-0.8	-0.7	-0.8	0.6
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.3	0.5
Patch foraging total patch changes 12 sec	0.5	0.7	0.8	-0.8	-0.8	-0.8	-0.9	0.7
Patch foraging total patch changes 18 sec	1.1	1.4	1.4	1.2	1.1	1.1	1.2	-1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.2	0.3	0.3	0.4	-0.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	0.4	0.4	0.7	0.7	-0.3
Patch foraging time to switch 0 sec	0.2	0.3	1.2	0.1	0.1	-0.2	-0.2	1.1
Patch foraging water rate 0 sec	0.7	1.1	1.6	-1.1	-1.3	-1.1	-1.1	-0.0
Patch foraging water rate 12 sec	3.0	4.6	5.8	-2.4	-2.3	-2.2	-2.2	1.3
Patch foraging water rate 18 sec	1.2	1.6	2.1	-1.4	-1.4	-1.3	-1.4	-0.2
Patch foraging water rate 24 sec	2.4	3.4	4.5	-2.0	-2.1	-2.0	-2.0	0.6
Patch foraging water rate 6 sec	0.3	0.4	0.5	-0.7	-0.6	-0.7	-0.6	-0.5
Seeking ratio, delayed vs. immediate footshock	4.7	5.4	5.8	2.2	2.4	2.3	2.4	-2.3
Distance traveled before self-admin	0.4	0.4	0.8	-0.7	-0.5	-0.6	-0.5	0.9
Distance traveled after self-admin	0.6	0.7	0.8	0.8	0.9	0.9	0.9	-0.7
Extensor digitorum longus weight	5.4	21.1	24.0	-4.5	-4.7	-4.7	-4.9	4.1
Bone: elastic displacement	0.1	0.1	0.3	0.2	0.3	0.3	0.5	-0.2
Bone: elastic work	0.3	0.4	0.6	-0.7	-0.5	-0.6	-0.4	0.8
Bone: endosteal estimation	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.4	0.4
Bone: endosteal perimeter	0.5	0.9	1.2	1.1	1.1	1.0	0.9	-0.8
Epididymis fat weight	0.2	0.5	0.7	0.7	0.7	0.7	0.7	-0.8
Delta time in closed arm before/after self-admin	2.8	2.7	3.5	-1.9	-1.7	-1.8	-1.8	0.8
Delta time in open arm before/after self-admin	0.8	0.8	1.5	-0.8	-0.8	-0.8	-0.8	1.2
Diff in mean of infusions in LGA sessions	2.1	2.3	2.5	1.5	1.5	1.5	1.5	-1.6
Delay discount exponential model param	2.4	2.5	2.7	1.6	1.5	1.6	1.6	-1.6
Extinction: sum of active levers before priming	0.7	0.7	1.4	0.8	0.8	0.7	0.6	-1.2
Active lever presses in extinction session 6	2.7	2.6	2.9	1.5	1.7	1.7	1.6	-1.5
Bone: final force	0.9	1.5	2.1	-1.1	-1.1	-1.2	-1.2	1.5
Bone: final moment	0.7	1.2	1.7	-1.0	-1.0	-1.1	-1.0	1.3
Food consumed during 24 hour testing period	1.0	1.2	2.0	-1.4	-1.0	-1.0	-1.0	0.9
Glucose	1.9	2.9	3.4	-1.8	-1.9	-1.7	-1.5	1.7
Heart weight	0.0	0.1	0.2	-0.0	0.0	0.3	0.2	-0.4
Delay discount hyperbolic model param	3.1	3.3	3.5	1.8	1.7	1.8	1.8	-1.9
Intermittent access intake day 1-15 change	5.8	5.7	7.3	2.3	2.3	2.3	2.2	-2.7
Intermittent access intake escalation	4.1	4.0	6.8	1.9	1.9	1.9	1.7	-2.6
Intermittent access intake escalation 2	5.1	5.0	8.0	2.1	2.1	2.1	2.0	-2.8
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.6	0.6	0.6	0.5	-0.8
Intermitt. access escalation Index	0.1	0.0	0.2	-0.1	-0.0	-0.0	0.1	0.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.2	0.3
Intermittent access day 15 total infusions	1.4	1.6	2.4	1.1	1.2	1.2	1.0	-1.5
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.2	1.0	1.1	1.1	0.8	-1.1
Intermittent access total infusions	0.1	0.1	0.2	0.3	0.4	0.4	0.2	-0.5
Intermittent access day 1 locomotion	0.3	0.4	0.5	0.5	0.6	0.6	0.5	-0.7
Intermittent access day 15 total locomotion	3.5	3.8	4.3	1.9	2.0	2.0	1.8	-2.1
Intermittent access total locomotion	1.0	1.2	1.3	1.1	1.2	1.2	1.0	-1.1
Intermittent access standard deviation	1.7	1.8	2.9	1.3	1.2	1.2	1.2	-1.7
Left kidney weight	0.1	0.2	0.3	0.4	0.5	0.4	0.5	-0.2
Right kidney weight	1.3	3.7	4.2	1.7	2.1	1.9	1.9	-2.0
Cocaine induced anxiety	1.2	1.4	1.6	1.2	1.3	1.3	1.3	-0.6
Post-drug Anxiety	1.2	1.4	1.6	1.3	1.3	1.3	1.3	-0.7
Baseline Anxiety	0.0	0.1	0.3	0.0	-0.0	-0.0	-0.0	-0.5
Tail length	2.7	8.2	11.0	2.8	2.9	2.7	2.5	-3.3
Length with tail	2.0	7.3	7.9	2.8	2.8	2.6	2.6	-2.7
Length without tail	0.3	0.6	1.0	1.0	0.8	0.8	0.9	-0.3
Times rat made contact with spout	0.7	0.8	1.2	-1.1	-0.9	-1.0	-0.9	0.4
Lifetime Intake	0.1	0.1	0.1	0.3	0.3	0.3	0.1	-0.3
Liver weight, left	2.3	3.7	4.0	-1.8	-1.9	-2.0	-2.0	1.9
Liver weight, right	1.1	1.8	2.2	-1.2	-1.1	-1.4	-1.4	1.5
Locomotor activity	4.1	6.6	7.9	2.7	2.8	2.5	2.6	-2.1
Locomotor testing distance	2.3	3.8	4.4	2.0	2.1	2.0	2.0	-1.6
Locomotor testing rearing	0.1	0.1	0.1	-0.3	-0.3	-0.4	-0.3	-0.1
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	0.0	0.0	0.2	-0.4
Locomotion in novel chamber post-restriction	0.5	0.7	1.4	0.8	0.7	0.6	0.6	-1.2
Fecal boli incidents, locomotor time 1	2.0	2.1	2.6	-1.4	-1.4	-1.6	-1.6	1.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.3	0.4	0.4	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.0	-0.5	-0.4	-0.4	-0.4	1.0
Bouts of movement, locomotor time 1	0.1	0.2	0.4	0.3	0.4	0.2	0.2	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.5	0.5	0.6	0.4	0.4	-0.7
Rest time, locomotor task time 1	0.7	0.8	1.0	1.0	1.0	0.7	0.7	-0.9
Distance moved, locomotor task time 1	0.4	0.4	1.3	-0.6	-0.5	-0.4	-0.3	1.1
Vertical activity count, locomotor time 1	1.0	1.1	1.5	-1.2	-1.2	-0.9	-0.9	0.8
Time >=10cm from walls, locomotor time 2	2.4	2.6	2.8	-1.6	-1.6	-1.7	-1.7	1.4
Bouts of movement, locomotor time 2	1.3	1.4	1.8	1.2	1.3	1.3	1.3	-0.7
Total resting periods, locomotor time 2	1.3	1.4	1.7	1.2	1.3	1.3	1.3	-0.7
Rest time, locomotor task time 2	1.0	1.1	1.5	1.0	1.2	1.1	1.1	-0.8
Distance moved, locomotor task time 2	0.9	1.1	1.2	-1.0	-1.0	-1.1	-1.1	0.9
Vertical activity count, locomotor time 2	1.5	1.7	2.1	-1.3	-1.4	-1.4	-1.5	0.9
Light reinforcement 1	7.3	13.3	14.3	3.7	3.8	3.6	3.7	-3.4
Light reinforcement 2	2.6	3.5	4.1	2.0	1.9	1.9	2.0	-1.6
Bone: marrow area	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.4	0.4
Bone: maximum diameter	1.2	2.2	2.6	1.6	1.6	1.5	1.5	-1.1
Bone: maximum force	1.1	1.9	2.1	-1.3	-1.3	-1.4	-1.3	1.5
Bone: maximum moment	0.9	1.5	1.8	-1.2	-1.2	-1.3	-1.2	1.3
Mean time between licks in bursts	3.6	5.1	6.3	2.2	2.0	2.4	2.2	-2.5
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	0.2
Cd content in liver	0.3	0.3	0.5	-0.5	-0.7	-0.5	-0.4	0.7
Co content in liver	0.5	0.5	0.8	0.9	0.7	0.5	0.6	-0.9
Cu content in liver	0.0	0.1	0.1	0.3	0.3	-0.0	0.1	0.3
Fe content in liver	0.1	0.1	0.3	0.6	0.1	-0.0	-0.1	-0.5
K content in liver	0.4	0.4	1.2	1.1	0.6	0.3	0.5	-0.2
Mg content in liver	0.3	0.3	0.8	0.9	0.5	0.4	0.5	-0.0
Mn content in liver	3.1	3.5	5.4	2.3	2.1	1.8	1.8	-1.2
Na content in liver	0.2	0.2	0.5	0.4	-0.1	-0.5	-0.4	0.7
Rb content in liver	0.1	0.1	0.4	0.1	0.0	-0.1	-0.0	0.7
Se content in liver	0.6	0.7	1.2	1.1	1.0	0.4	0.6	-0.9
Sr content in liver	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.1
Zn content in liver	0.5	0.5	1.8	0.3	0.4	0.5	0.5	-1.3
Bone: minimum diameter	0.0	0.0	0.2	0.4	0.2	0.1	0.1	-0.1
Time in familiar zone, hab. session 1	1.6	1.5	2.3	1.0	1.3	1.2	1.0	-1.5
Time in novel zone, hab. session 1	0.6	0.6	1.3	-0.5	-0.7	-0.7	-0.5	1.1
Total zone transitions, hab. session 1	2.3	3.3	4.2	2.1	1.9	1.9	1.9	-1.2
Total locomotion distance, hab. session 1	3.3	4.7	6.8	2.6	2.4	2.2	2.1	-1.4
Locomotion velocity, hab. session 1	4.1	5.8	8.0	2.8	2.6	2.4	2.4	-1.7
Time in familiar zone, hab. session 2	4.6	4.7	6.9	1.8	2.1	2.1	2.1	-2.6
Time in novel zone, hab. session 2	3.8	3.8	5.4	-2.0	-1.8	-1.8	-1.8	2.3
Total zone transitions, hab. session 2	0.5	0.6	0.9	0.7	0.9	0.9	0.9	0.3
Total locomotion distance, hab. session 2	2.7	3.5	4.6	1.8	2.1	2.1	2.0	-1.2
Locomotion velocity, hab. session 2	3.0	4.0	5.3	1.9	2.3	2.3	2.2	-1.2
Novel to familiar place preference ratio	2.7	2.8	5.2	-1.4	-1.6	-1.6	-1.5	2.3
Novelty place preference	1.5	1.5	3.1	-1.0	-1.1	-1.1	-1.0	1.8
Time in novel zone, NPP test	1.8	1.9	3.4	-1.2	-1.2	-1.3	-1.2	1.8
Total zone transitions, NPP test	0.5	0.7	1.0	0.9	0.9	0.9	1.0	0.0
Total locomotion distance, NPP test	0.5	0.7	1.1	1.0	0.9	0.9	0.8	-0.0
Locomotion velocity, NPP test	0.8	1.1	1.5	1.2	1.1	1.1	1.1	-0.3
Intraocular pressure	0.4	0.6	1.2	-1.1	-0.9	-0.6	-0.7	0.1
Delta distance traveled before/after self-admin	2.0	2.1	2.5	1.6	1.4	1.4	1.4	-1.5
Delta ambulatory time before/after self-admin	2.3	2.6	3.0	1.7	1.6	1.5	1.5	-1.6
Parametrial fat weight	0.2	0.4	0.9	0.4	0.7	0.6	0.5	-0.9
Pavlov. Cond. lever latency	0.5	0.6	1.4	-1.2	-1.0	-0.5	-0.5	0.3
Pavlov. Cond. magazine entry latency	4.0	5.1	6.2	2.4	2.3	2.1	2.0	-2.5
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	0.9	0.8	0.5	0.4	-0.7
Pavlov. Cond. index score	1.6	2.0	3.3	1.8	1.6	1.2	1.1	-1.2
Pavlov. Cond. latency score	1.9	2.4	4.0	2.0	1.7	1.3	1.2	-1.2
Pavlov. Cond. lever contacts	0.9	1.1	2.2	1.5	1.2	0.8	0.8	-0.5
Pavlov. Cond. magazine entry number	1.5	1.8	2.4	-1.6	-1.4	-1.2	-1.1	1.4
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.4	-0.2	-0.2	-0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.6	3.9	2.0	1.8	1.4	1.3	-1.5
Pavlov. Cond. response bias	2.1	2.5	3.5	1.9	1.6	1.4	1.3	-1.6
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.6	-0.5	-0.5	-0.6	0.8
Pavlov. Cond. magazine entry latency	0.4	0.4	0.6	0.7	0.6	0.5	0.5	-0.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	0.4	0.3	0.5	0.5	-0.7
Pavlov. Cond. index score	0.4	0.5	0.8	0.7	0.5	0.5	0.6	-0.9
Pavlov. Cond. latency score	0.4	0.5	0.7	0.7	0.6	0.6	0.7	-0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.5	0.3	0.4	0.4	-0.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	-1.0	-0.8	-0.7	-0.7	1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.1	-1.0	-1.0	-1.0	-1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	0.8	0.7	0.6	0.7	-0.9
Pavlov. Cond. response bias	0.8	1.0	2.1	0.9	0.8	0.8	0.9	-1.4
Time in closed arm before self-admin	0.1	0.1	0.7	0.1	-0.1	-0.1	-0.1	0.8
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	-0.2
Time in open arm before self-admin	0.4	0.4	0.8	0.6	0.6	0.6	0.6	-0.9
Time in open arm after self-admin	0.9	1.0	1.1	-1.1	-1.0	-1.0	-1.0	1.1
Bone: periosteal estimation	0.1	0.2	0.5	-0.3	-0.2	-0.4	-0.3	0.7
Bone: periosteal perimeter	0.2	0.4	0.6	0.8	0.7	0.6	0.6	-0.3
Bone: post-yield work	0.6	0.8	1.2	-0.7	-0.9	-1.1	-1.1	0.6
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	-0.4	-0.4	-0.5	0.1
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	-0.6	-0.5	-0.5	-0.6	0.2
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.1	0.3	0.3	0.2	-0.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.0	0.0	0.0	-0.1	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	0.3	0.3	0.2	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	0.5	0.5	0.2	-0.2
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.0	0.1	0.1	-0.1	-0.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.2	0.1	0.1	0.1
Progressive ratio	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.4	0.2
Food seeking constrained by brief footshock	0.8	1.0	1.3	1.1	1.1	1.0	0.9	-0.9
Seeking ratio, punishment vs. effort	0.4	0.5	0.6	0.8	0.7	0.7	0.8	-0.5
Retroperitoneal fat weight	0.2	0.8	0.9	-0.9	-0.9	-0.9	-1.0	0.7
Reaction time number correct	1.7	2.5	3.0	-1.7	-1.7	-1.7	-1.7	0.7
Reaction time mean minus median	0.3	0.4	0.8	0.6	0.5	0.6	0.5	-0.9
Reaction time mean minus median AUC	0.1	0.1	0.1	0.4	0.3	0.3	0.2	-0.0
Reaction time num false alarms	0.6	0.8	1.3	-0.8	-1.0	-1.0	-1.1	0.3
Reaction time num false alarms AUC	0.8	1.1	1.7	-0.9	-1.2	-1.2	-1.3	0.4
Reaction time trials correct on left	1.7	2.5	3.0	-1.7	-1.7	-1.7	-1.7	0.7
Reaction time trials on left	1.7	2.4	3.0	-1.7	-1.7	-1.7	-1.7	0.7
Reaction time mean	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.0	0.2
Reaction time mean AUC	0.0	0.1	0.1	-0.2	-0.2	-0.2	-0.0	0.4
Median of all reaction times	0.2	0.3	0.6	-0.5	-0.5	-0.6	-0.3	0.7
Reaction time omissions	0.2	0.3	0.6	0.3	0.5	0.7	0.8	-0.3
Reaction time false alarm rate	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.4	0.2
Reaction time premature initiation rate	0.5	0.6	1.1	0.5	0.6	0.8	0.8	-1.0
Reaction time premature initiations	0.1	0.2	0.6	-0.3	-0.3	-0.0	-0.0	-0.8
Std. dev. reaction times	0.1	0.1	0.1	0.3	0.1	0.2	0.3	-0.4
Reaction time trials completed	1.7	2.4	3.0	-1.7	-1.7	-1.7	-1.7	0.7
Reaction time trials AUC	1.8	2.6	3.3	-1.8	-1.8	-1.7	-1.8	0.7
Run reversals in cocaine runway, females	0.6	0.6	0.7	0.7	0.8	0.8	0.8	-0.8
Run reversals in cocaine runway, males	2.0	2.0	2.2	1.4	1.4	1.5	1.5	-1.3
Latency to leave start box in cocaine runway	1.0	1.1	1.9	1.2	1.1	1.0	1.4	-0.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.4	0.3	0.2	0.6	0.7
Latency to leave start box in cocaine runway, M	1.5	1.5	3.1	1.1	1.0	1.0	1.0	-1.8
Std. dev. time between licks in bursts	0.8	0.9	1.2	1.0	0.8	1.1	1.0	-0.9
Total sessions with >9 infusions	0.0	0.0	0.0	-0.0	0.1	0.1	-0.0	0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.3	0.4	0.5	0.5	0.3	-0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	0.0
Short access day 1 total infusions	0.6	0.7	0.9	0.9	1.0	1.0	0.8	-0.4
Short access day 10 total infusions	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.2	-0.3
Short access total infusions	0.0	0.0	0.0	0.1	0.2	0.2	0.0	0.0
Short access day 1 locomotion	1.4	1.5	1.9	1.2	1.4	1.4	1.2	-1.0
Short access day 10 total locomotion	2.8	3.2	4.4	1.8	1.7	1.7	1.7	-2.1
Short access total locomotion	0.9	0.9	1.1	1.0	1.0	1.0	0.9	-0.9
One hour access (0.3 mA shock)	0.1	0.2	0.2	-0.3	-0.4	-0.4	-0.5	0.4
Compulsive drug intake	0.9	0.9	1.6	-0.8	-0.9	-0.9	-0.8	1.3
One hour access (shock baseline)	0.0	0.0	0.2	-0.0	-0.1	-0.1	-0.2	-0.4
Social response proportion	1.3	1.4	2.0	1.2	1.1	1.3	1.4	-0.8
Social responses	7.8	10.0	10.7	3.3	3.2	3.2	3.2	-3.0
Social time	0.4	0.5	0.9	-0.6	-0.7	-0.7	-0.5	0.9
Soleus weight	9.2	27.0	28.5	-5.1	-5.1	-5.1	-5.3	5.3
Bone: stiffness	2.2	3.5	4.0	-1.6	-1.8	-1.9	-2.0	2.0
Tibialis anterior weight	1.1	3.6	4.4	-1.6	-1.9	-2.0	-2.1	1.8
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.3	1.0	1.1	1.1	1.1	-0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.2	-0.5
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.8	0.9	0.8	0.8	-0.3
Time to tail flick, test, after self-admin	0.5	0.5	0.6	0.8	0.7	0.8	0.8	-0.6
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.6	-1.0	-1.1	-1.2	-1.3	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.1	0.0	0.1	0.0	-0.6
Tibia length	0.7	2.0	2.6	1.4	1.4	1.3	1.3	-1.6
Ambulatory time before self-admin	0.4	0.4	0.7	-0.7	-0.5	-0.6	-0.5	0.9
Ambulatory time after self-admin	0.4	0.4	0.5	0.6	0.7	0.6	0.7	-0.5
Bone: tissue strength	1.4	1.4	2.1	-1.1	-1.1	-1.1	-1.0	1.5
Total heroin consumption	2.1	2.5	2.7	1.5	1.6	1.6	1.6	-1.5
Bone: trabecular number	1.5	2.4	3.2	1.7	1.8	1.6	1.5	-0.8
Bone: trabecular spacing	2.2	2.9	3.8	-1.9	-1.9	-1.9	-1.8	0.6
Bone: trabecular thickness	1.1	1.3	1.8	1.2	1.4	1.2	1.2	0.5
Bone: trabecular tissue density	1.7	2.4	2.7	-1.6	-1.6	-1.6	-1.6	1.4
Water consumed over 24 hours	0.4	0.5	0.8	-0.7	-0.6	-0.8	-0.6	0.9
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.4	0.4	0.2	-0.3