Fgf22

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Fgf22	0.12	0.07	2.0e-06	0.06	0.06	0.06	0.06	7.4e-06	4.7e-06	4.2e-06	4.4e-06
2	PL	gene expression	Fgf22	0.07	0.05	1.1e-06	0.05	0.06	0.05	0.06	5.2e-06	7.3e-07	3.6e-06	1.0e-06
3	pVTA	gene expression	Fgf22	0.06	0.05	1.8e-04	0.04	0.04	0.04	0.04	3.2e-04	3.4e-04	1.6e-04	2.1e-04
4	BLA	gene expression	Fgf22	0.2	0.13	1.7e-05	0.12	0.09	0.09	0.1	8.7e-07	3.0e-05	2.5e-05	7.4e-06
5	NAcc	gene expression	Fgf22	0.06	0.04	9.6e-11	0.05	0.06	0.06	0.06	5.0e-08	5.0e-10	1.7e-09	7.2e-10
6	LHb	gene expression	Fgf22	0.17	0.11	4.7e-04	0.09	0.1	0.08	0.09	3.2e-03	2.3e-03	6.8e-03	4.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	1.2	1.1	-0.2	0.3	0.7	0.2	0.7
Area under the delay curve	1.7	2.6	2.7	-1.5	1.6	-1.7	-1.6	1.7	1.6
BMI with tail	6.6	23.0	24.3	-4.4	4.9	-4.9	-4.8	4.9	4.8
BMI without tail	1.3	7.1	8.0	-2.7	2.7	-2.8	-2.8	2.6	2.4
Body weight	1.0	4.2	4.6	-1.9	2.1	-2.1	-2.1	2.1	2.1
Weight adjusted by age	0.3	1.0	1.4	-1.2	1.0	-1.0	-1.1	0.9	0.7
Bone surface	0.9	1.8	4.6	2.2	-1.1	1.2	1.7	-0.6	0.0
Bone volume	0.7	1.4	3.9	2.0	-0.9	1.0	1.6	-0.4	0.2
Breakpoint value in progressive ratio session	2.3	4.1	4.8	1.7	-2.1	2.1	1.9	-2.1	-2.2
Number of licking bursts	0.1	0.3	0.5	-0.7	0.5	-0.5	-0.7	0.3	0.0
Context. condit. distance diff. score	0.2	0.2	0.5	-0.3	0.4	-0.6	-0.7	0.3	0.2
Locomotion velocity, session 1	0.9	1.1	1.8	1.3	-1.0	1.0	1.2	-0.8	-0.5
Locomotion distance, session 1	1.4	1.7	4.0	2.0	-1.4	1.2	1.4	-1.0	-0.5
Locomotion velocity, session 2	7.0	8.4	10.5	3.2	-3.0	2.9	3.0	-2.8	-2.4
Locomotion distance, session 2	3.3	4.6	6.9	2.6	-2.1	2.2	2.6	-1.8	-1.2
Locomotion velocity, session 3	6.6	7.5	9.2	2.3	-2.8	2.8	2.5	-2.9	-3.0
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.2	-0.1	-0.2
Stereotopy head waving bouts, day 3	6.9	8.2	8.7	2.8	-2.9	2.9	2.8	-2.9	-2.8
Stereotopy head waving duration, day 3	7.3	9.0	9.5	2.9	-3.1	3.1	2.9	-3.1	-3.0
Locomotion velocity, session 7	0.6	0.6	1.1	0.8	-0.9	0.6	0.3	-0.9	-1.1
Locomotion distance, session 7	0.4	0.5	1.2	-0.8	0.7	-0.8	-1.1	0.5	0.3
Stereotopy head waving bouts, day 7	0.2	0.3	1.0	1.0	-0.4	0.4	0.5	-0.3	-0.0
Stereotopy head waving duration, day 7	0.9	1.1	2.3	1.5	-1.0	1.0	1.2	-0.8	-0.5
Locomotion velocity, session 8	1.7	2.1	2.6	1.6	-1.5	1.5	1.6	-1.3	-1.0
Locomotion distance, session 8	0.6	0.9	1.7	1.3	-1.0	0.9	0.9	-0.9	-0.7
Degree of sensitization distance	0.4	0.4	0.6	-0.4	0.6	-0.7	-0.8	0.6	0.6
Degree of sensitization stereotypy	1.1	1.2	2.1	-0.5	1.1	-1.1	-0.9	1.3	1.4
Conditioned locomotion	2.3	2.7	4.5	-2.1	1.6	-1.6	-1.8	1.4	1.1
Cocaine response after cond. corrected	6.5	9.7	11.8	-3.4	3.2	-3.2	-3.3	2.9	2.5
Cocaine response after cond. not corrected	6.8	9.8	11.6	-3.4	3.2	-3.3	-3.4	2.9	2.5
Cocaine response before conditioning	0.8	1.0	1.4	1.2	-1.0	0.9	0.9	-1.0	-0.9
Saline control response	0.3	0.4	0.7	-0.8	0.6	-0.6	-0.6	0.5	0.4
Bone: connectivity density	0.1	0.2	0.7	0.6	0.2	-0.1	0.1	0.5	0.8
Bone: cortical apparent density	1.0	1.6	2.0	-1.2	1.4	-1.1	-1.0	1.4	1.4
Bone: cortical area	0.2	0.3	0.7	0.1	0.5	-0.5	-0.4	0.7	0.8
Bone: cortical porosity	0.3	0.3	0.5	0.7	-0.5	0.6	0.7	-0.4	-0.2
Bone: cortical porosity	0.2	0.3	0.7	0.8	-0.4	0.5	0.7	-0.2	0.1
Bone: cortical thickness	0.8	1.3	2.1	-0.5	1.2	-1.1	-1.0	1.3	1.5
Bone: cortical thickness	0.1	0.2	0.3	-0.5	0.4	-0.4	-0.6	0.2	-0.1
Bone: cortical tissue density	0.7	1.2	1.5	-1.1	1.2	-1.0	-0.8	1.2	1.2
Condit. Reinf. active minus inactive responses	4.9	5.6	6.2	2.0	-2.4	2.4	2.3	-2.5	-2.5
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.5	0.8	-1.3	1.3	1.2	-1.4	-1.6
Condit. Reinf. active responses	5.0	6.4	7.3	2.4	-2.6	2.6	2.7	-2.5	-2.3
Condit. Reinf. inactive responses	1.8	2.3	3.3	1.8	-1.5	1.5	1.8	-1.3	-0.9
Incentive salience index mean	3.5	4.5	4.9	2.1	-2.2	2.2	2.1	-2.1	-2.0
Condit. Reinf. lever presses	0.6	0.8	2.0	1.4	-0.9	0.8	1.1	-0.5	-0.1
Condit. Reinf. active minus inactive responses	0.9	1.4	2.4	0.7	-1.1	1.2	1.0	-1.3	-1.5
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.6	-0.7	0.5	-0.3	-0.3	0.3	0.1
Condit. Reinf. active responses	1.3	1.9	2.7	1.0	-1.3	1.4	1.2	-1.5	-1.6
Condit. Reinf. inactive responses	0.9	1.3	1.9	0.8	-1.2	1.1	0.9	-1.3	-1.4
Condit. Reinf. lever presses	1.1	1.6	2.4	0.9	-1.3	1.3	1.1	-1.4	-1.6
Condit. Reinf. lever reinforcers received	0.7	1.0	1.9	0.6	-1.0	1.0	0.8	-1.2	-1.4
Conditioned reinforcement - actives	0.2	0.8	1.5	0.7	-0.9	0.7	0.5	-1.0	-1.2
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.2	0.3	-0.3	-0.5	0.2	0.1
Conditioned locomotion	6.1	9.1	9.9	2.9	-3.0	3.1	3.0	-3.1	-3.0
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.2	0.5	-0.5	-0.3	0.6	0.7
Patch foraging indifference point AUC	0.3	0.8	0.9	0.7	-0.9	0.9	0.9	-0.9	-1.0
Delay disc. indifference point, 0s delay	5.1	5.7	9.9	-1.4	2.4	-2.3	-1.9	2.8	3.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.2	-0.5	0.4	-0.4	-0.4	0.5	0.5
Delay disc. indifference point, 2s delay	5.0	5.6	7.3	-1.8	2.4	-2.4	-2.2	2.6	2.7
Delay disc. indifference point, 24s delay	0.7	1.2	1.6	-1.2	1.1	-1.0	-1.1	1.1	1.0
Delay disc. indifference point, 4s delay	0.9	1.0	1.3	-0.8	1.0	-1.0	-0.9	1.1	1.1
Delay disc. indifference point, 8s delay	1.3	2.2	2.7	-1.5	1.4	-1.6	-1.7	1.4	1.2
Indifference point function ln k	0.1	0.3	0.5	-0.7	0.6	-0.6	-0.7	0.5	0.4
Indifference point function log k	0.1	0.3	0.5	-0.7	0.6	-0.6	-0.7	0.5	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.2	0.4	-0.4	-0.2	0.5	0.5
Patch foraging total patch changes 12 sec	0.5	0.7	0.9	-0.7	0.9	-0.9	-0.9	0.8	0.8
Patch foraging total patch changes 18 sec	0.5	1.2	1.4	1.1	-1.1	1.1	1.2	-1.1	-1.0
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.5	-0.3	0.4	0.5	-0.2	-0.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	0.6	-0.4	0.5	0.8	-0.4	-0.2
Patch foraging time to switch 0 sec	0.1	0.5	1.5	0.5	0.5	-0.5	-0.2	0.8	1.2
Patch foraging water rate 0 sec	0.2	0.7	2.0	-1.4	0.7	-0.8	-1.0	0.3	-0.1
Patch foraging water rate 12 sec	0.9	3.7	6.5	-2.6	1.9	-1.9	-2.2	1.6	1.2
Patch foraging water rate 18 sec	0.5	1.1	3.0	-1.7	0.8	-1.0	-1.3	0.3	-0.4
Patch foraging water rate 24 sec	1.9	2.8	6.3	-2.5	1.5	-1.6	-2.0	1.1	0.5
Patch foraging water rate 6 sec	0.2	0.3	1.1	-1.0	0.1	-0.2	-0.6	-0.2	-0.6
Seeking ratio, delayed vs. immediate footshock	3.6	5.1	5.8	2.0	-2.3	2.4	2.4	-2.3	-2.2
Distance traveled before self-admin	0.1	0.2	0.3	-0.3	0.4	-0.4	-0.2	0.5	0.6
Distance traveled after self-admin	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.0
Extensor digitorum longus weight	4.8	19.0	22.1	-4.4	4.3	-4.6	-4.7	4.2	3.8
Bone: elastic displacement	0.0	0.0	0.2	0.1	-0.1	0.2	0.4	-0.1	-0.1
Bone: elastic work	0.4	0.6	0.8	-0.6	0.8	-0.8	-0.6	0.9	0.9
Bone: endosteal estimation	0.1	0.2	0.2	-0.4	0.4	-0.5	-0.4	0.4	0.4
Bone: endosteal perimeter	0.4	1.0	1.4	1.2	-1.0	0.9	0.9	-1.0	-0.8
Epididymis fat weight	0.0	0.1	0.3	-0.4	0.3	-0.4	-0.6	0.1	-0.2
Delta time in closed arm before/after self-admin	2.3	2.2	4.3	-2.1	1.4	-1.5	-1.7	1.1	0.7
Delta time in open arm before/after self-admin	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.7	0.8	0.8
Diff in mean of infusions in LGA sessions	1.3	2.4	2.6	1.4	-1.6	1.6	1.5	-1.6	-1.5
Delay discount exponential model param	1.7	2.3	2.4	1.4	-1.5	1.5	1.5	-1.5	-1.5
Extinction: sum of active levers before priming	0.5	0.7	1.1	0.7	-0.9	0.8	0.6	-0.9	-1.0
Active lever presses in extinction session 6	2.2	2.2	2.4	1.5	-1.5	1.6	1.5	-1.5	-1.3
Bone: final force	0.9	1.5	2.1	-0.7	1.2	-1.3	-1.1	1.4	1.5
Bone: final moment	0.8	1.2	1.8	-0.7	1.1	-1.2	-1.0	1.2	1.3
Food consumed during 24 hour testing period	0.5	1.1	1.2	-1.1	1.0	-1.1	-1.1	1.0	0.9
Glucose	3.3	5.2	5.7	-2.2	2.4	-2.3	-2.2	2.4	2.3
Heart weight	0.2	0.3	0.9	0.2	-0.5	0.4	0.2	-0.7	-1.0
Delay discount hyperbolic model param	2.8	3.6	3.9	1.7	-1.9	2.0	1.9	-2.0	-1.9
Intermittent access intake day 1-15 change	0.9	5.1	7.4	1.7	-2.4	2.1	1.9	-2.6	-2.7
Intermittent access intake escalation	0.8	4.4	6.6	1.5	-2.2	2.0	1.8	-2.4	-2.6
Intermittent access intake escalation 2	2.4	4.0	5.5	1.6	-2.1	1.9	1.8	-2.2	-2.4
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	-0.6	0.1	-0.3	-0.6	-0.1	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.6	0.7	0.8	-0.8	0.8	0.7	-0.8	-0.8
Intermitt. access escalation Index	0.2	0.5	1.2	-0.4	0.7	-0.6	-0.3	0.9	1.1
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.1	-0.1	0.1	-0.2	-0.3	-0.4
Intermittent access day 15 total infusions	1.1	2.8	4.1	1.4	-1.8	1.6	1.3	-1.9	-2.0
Intermittent access terminal intake (last 3 days)	1.2	2.1	2.9	1.4	-1.5	1.3	1.0	-1.6	-1.7
Intermittent access total infusions	0.7	0.8	1.3	0.8	-0.9	0.8	0.6	-1.0	-1.1
Intermittent access day 1 locomotion	0.6	1.2	2.3	0.6	-1.1	1.0	0.7	-1.3	-1.5
Intermittent access day 15 total locomotion	1.1	4.3	6.2	1.5	-2.1	2.1	1.8	-2.3	-2.5
Intermittent access total locomotion	1.8	2.2	3.3	1.1	-1.5	1.5	1.2	-1.7	-1.8
Intermittent access standard deviation	1.3	6.9	7.8	2.5	-2.7	2.6	2.4	-2.8	-2.8
Left kidney weight	0.0	0.3	0.8	-0.9	0.3	-0.5	-0.8	0.0	-0.3
Right kidney weight	0.1	1.0	2.6	0.0	-1.0	0.8	0.5	-1.3	-1.6
Cocaine induced anxiety	1.0	2.8	4.2	2.0	-1.6	1.7	1.9	-1.4	-1.1
Post-drug Anxiety	2.5	2.9	4.3	2.1	-1.7	1.8	1.9	-1.5	-1.1
Baseline Anxiety	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	-0.2	-0.3
Tail length	2.2	11.6	14.7	2.7	-3.6	3.4	3.1	-3.7	-3.8
Length with tail	1.7	7.7	9.7	2.3	-2.9	2.7	2.5	-3.0	-3.1
Length without tail	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3	0.1	0.1
Times rat made contact with spout	0.5	0.6	1.4	-1.2	0.7	-0.7	-0.8	0.6	0.4
Lifetime Intake	0.3	0.4	0.7	0.6	-0.7	0.6	0.3	-0.7	-0.8
Liver weight, left	1.1	1.8	2.1	-1.4	1.4	-1.3	-1.3	1.4	1.3
Liver weight, right	0.9	1.6	2.3	-1.5	1.2	-1.3	-1.5	1.1	0.9
Locomotor activity	3.8	6.0	7.2	2.7	-2.5	2.5	2.6	-2.3	-2.0
Locomotor testing distance	1.5	3.8	4.8	2.2	-2.0	2.0	2.1	-1.8	-1.5
Locomotor testing rearing	0.0	0.1	0.2	-0.5	0.1	-0.1	-0.3	-0.0	-0.2
Locomotion in novel chamber	0.5	0.7	1.0	0.5	-0.8	0.9	0.9	-0.9	-1.0
Locomotion in novel chamber post-restriction	0.5	1.5	2.4	0.9	-1.3	1.2	0.9	-1.4	-1.5
Fecal boli incidents, locomotor time 1	0.7	1.8	2.1	-1.1	1.3	-1.4	-1.5	1.3	1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	0.5	-0.5	0.5	0.4	-0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.0	-0.2	0.5	-0.5	-0.3	0.7	1.0
Bouts of movement, locomotor time 1	0.3	0.4	0.8	0.3	-0.7	0.6	0.4	-0.8	-0.9
Total resting periods, locomotor time 1	0.5	0.5	0.9	0.5	-0.8	0.7	0.5	-0.9	-0.9
Rest time, locomotor task time 1	0.5	0.7	1.0	0.8	-1.0	0.8	0.7	-0.9	-0.9
Distance moved, locomotor task time 1	0.3	0.7	1.7	-0.3	0.9	-0.7	-0.4	1.1	1.3
Vertical activity count, locomotor time 1	0.2	1.1	1.4	-1.2	1.1	-1.0	-0.9	1.0	0.9
Time >=10cm from walls, locomotor time 2	0.8	2.4	2.8	-1.6	1.5	-1.6	-1.7	1.5	1.4
Bouts of movement, locomotor time 2	0.3	0.9	1.4	1.1	-1.0	1.0	1.2	-0.8	-0.6
Total resting periods, locomotor time 2	0.2	0.9	1.4	1.2	-0.9	1.0	1.2	-0.8	-0.5
Rest time, locomotor task time 2	0.7	1.2	1.4	1.2	-1.1	1.1	1.2	-1.0	-0.9
Distance moved, locomotor task time 2	0.6	0.9	1.0	-0.9	0.9	-1.0	-1.0	0.9	0.8
Vertical activity count, locomotor time 2	0.5	1.2	1.8	-1.2	1.1	-1.2	-1.4	0.9	0.7
Light reinforcement 1	2.9	13.4	14.6	3.8	-3.7	3.8	3.8	-3.6	-3.3
Light reinforcement 2	1.6	3.6	4.4	2.1	-1.8	2.0	2.1	-1.7	-1.5
Bone: marrow area	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4	0.4	0.4
Bone: maximum diameter	1.3	2.5	3.9	2.0	-1.6	1.6	1.6	-1.5	-1.3
Bone: maximum force	0.9	1.8	2.1	-1.0	1.4	-1.4	-1.3	1.4	1.5
Bone: maximum moment	0.8	1.6	1.9	-1.0	1.3	-1.3	-1.2	1.4	1.4
Mean time between licks in bursts	1.0	5.8	6.6	1.9	-2.4	2.5	2.4	-2.5	-2.6
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.0	0.1	0.2
Cd content in liver	0.1	0.1	0.3	0.3	-0.3	0.5	0.6	-0.3	-0.2
Co content in liver	1.1	1.3	1.7	0.9	-1.2	1.2	1.1	-1.2	-1.3
Cu content in liver	0.6	0.7	1.2	1.1	-0.9	0.8	0.9	-0.7	-0.5
Fe content in liver	0.3	0.4	0.6	0.6	-0.6	0.4	0.2	-0.7	-0.8
K content in liver	0.3	0.3	0.9	0.9	-0.5	0.5	0.6	-0.4	-0.2
Mg content in liver	0.4	0.4	0.6	0.7	-0.6	0.7	0.8	-0.5	-0.4
Mn content in liver	2.9	3.3	5.0	2.2	-1.8	1.8	1.9	-1.6	-1.3
Na content in liver	0.2	0.3	0.7	0.4	0.3	-0.4	-0.3	0.6	0.8
Rb content in liver	0.3	0.3	1.0	1.0	-0.4	0.5	0.7	-0.2	0.0
Se content in liver	0.5	0.6	0.8	0.8	-0.8	0.6	0.4	-0.8	-0.9
Sr content in liver	0.1	0.1	0.1	-0.4	0.2	-0.2	-0.3	0.1	0.0
Zn content in liver	1.6	1.9	3.6	0.4	-1.3	1.4	1.2	-1.6	-1.9
Bone: minimum diameter	0.0	0.0	0.1	0.3	-0.2	0.1	0.0	-0.1	-0.1
Time in familiar zone, hab. session 1	1.4	1.6	2.3	1.0	-1.3	1.2	1.0	-1.4	-1.5
Time in novel zone, hab. session 1	0.6	0.7	1.4	-0.4	0.8	-0.8	-0.6	1.0	1.2
Total zone transitions, hab. session 1	1.9	2.7	4.0	2.0	-1.7	1.7	1.9	-1.4	-1.1
Total locomotion distance, hab. session 1	3.0	4.2	7.5	2.7	-2.1	2.0	2.2	-1.8	-1.3
Locomotion velocity, hab. session 1	3.7	5.2	7.9	2.8	-2.4	2.3	2.4	-2.1	-1.6
Time in familiar zone, hab. session 2	4.7	5.3	7.3	1.8	-2.3	2.3	2.1	-2.5	-2.7
Time in novel zone, hab. session 2	3.9	4.3	5.6	-1.9	2.0	-2.0	-1.8	2.2	2.4
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.9	-0.5	0.5	0.9	-0.1	0.5
Total locomotion distance, hab. session 2	2.3	3.0	4.1	1.9	-1.8	1.8	2.0	-1.6	-1.2
Locomotion velocity, hab. session 2	2.5	3.4	4.8	2.1	-1.9	2.0	2.2	-1.6	-1.1
Novel to familiar place preference ratio	2.6	3.4	5.5	-1.2	1.9	-1.8	-1.5	2.1	2.3
Novelty place preference	1.5	1.9	3.3	-0.9	1.4	-1.3	-1.1	1.6	1.8
Time in novel zone, NPP test	1.8	2.2	3.6	-1.0	1.5	-1.5	-1.2	1.7	1.9
Total zone transitions, NPP test	0.3	0.5	1.4	1.2	-0.6	0.6	0.9	-0.3	0.2
Total locomotion distance, NPP test	0.3	0.5	1.3	1.1	-0.6	0.6	0.8	-0.4	0.0
Locomotion velocity, NPP test	0.6	0.8	1.7	1.3	-0.9	0.9	1.1	-0.6	-0.2
Intraocular pressure	0.4	0.7	2.1	-1.4	0.8	-0.7	-0.8	0.5	0.2
Delta distance traveled before/after self-admin	0.4	0.4	0.6	0.6	-0.7	0.6	0.5	-0.7	-0.8
Delta ambulatory time before/after self-admin	0.3	0.5	0.6	0.8	-0.8	0.7	0.6	-0.8	-0.8
Parametrial fat weight	0.0	0.0	0.1	0.2	-0.2	0.2	0.3	-0.1	0.0
Pavlov. Cond. lever latency	0.4	0.5	1.3	-1.1	0.8	-0.6	-0.7	0.6	0.3
Pavlov. Cond. magazine entry latency	4.2	5.4	6.1	2.0	-2.5	2.3	2.1	-2.5	-2.5
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.7	-0.7	0.5	0.3	-0.7	-0.6
Pavlov. Cond. index score	1.3	1.6	2.1	1.4	-1.4	1.2	1.1	-1.3	-1.2
Pavlov. Cond. latency score	1.4	1.8	2.6	1.6	-1.5	1.2	1.2	-1.3	-1.1
Pavlov. Cond. lever contacts	0.4	0.4	1.0	1.0	-0.8	0.5	0.6	-0.5	-0.3
Pavlov. Cond. magazine entry number	1.3	1.7	2.1	-1.0	1.4	-1.3	-1.1	1.4	1.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.4	0.1	-0.0	-0.1	-0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.3	1.4	-1.5	1.3	1.1	-1.4	-1.3
Pavlov. Cond. response bias	1.4	1.7	2.2	1.1	-1.5	1.3	1.1	-1.5	-1.5
Pavlov. Cond. lever latency	0.3	0.5	0.7	-0.5	0.7	-0.7	-0.6	0.8	0.8
Pavlov. Cond. magazine entry latency	0.3	0.5	0.6	0.6	-0.7	0.6	0.5	-0.7	-0.8
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.3	-0.5	0.5	0.4	-0.6	-0.7
Pavlov. Cond. index score	0.3	0.4	0.7	0.4	-0.6	0.6	0.5	-0.7	-0.8
Pavlov. Cond. latency score	0.3	0.5	0.7	0.5	-0.7	0.7	0.6	-0.8	-0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.3	-0.5	0.5	0.3	-0.6	-0.7
Pavlov. Cond. magazine entry number	0.6	0.8	1.0	-0.8	0.9	-0.9	-0.7	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.2	-1.1	0.9	-0.8	-0.9	0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.8	0.6	-0.8	0.7	0.6	-0.8	-0.9
Pavlov. Cond. response bias	0.8	1.1	1.9	0.6	-1.0	1.0	0.9	-1.2	-1.4
Time in closed arm before self-admin	0.1	0.1	0.4	0.3	0.2	-0.2	-0.0	0.4	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	-0.0	-0.2	0.2	0.0	-0.3	-0.5
Time in open arm before self-admin	0.1	0.1	0.2	0.4	-0.3	0.4	0.4	-0.3	-0.3
Time in open arm after self-admin	1.1	1.3	1.4	-1.0	1.2	-1.1	-1.0	1.2	1.2
Bone: periosteal estimation	0.1	0.1	0.3	0.1	0.3	-0.3	-0.2	0.4	0.6
Bone: periosteal perimeter	0.2	0.4	1.0	1.0	-0.7	0.6	0.6	-0.5	-0.3
Bone: post-yield work	0.5	0.9	1.4	-1.1	0.9	-1.0	-1.2	0.8	0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.3	-0.0	-0.1	-0.5	-0.2	-0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.3	0.0	-0.2	-0.5	-0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.6	0.4	-0.5	0.5	0.2	-0.6	-0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.3	-0.0	-0.1	-0.4	-0.2	-0.5
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.3	-0.1	-0.1	-0.4	-0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.3	0.6	-0.4	0.3	0.2	-0.4	-0.4
Incentive Sensitization - Responses	0.1	0.4	0.7	-0.8	0.5	-0.7	-0.8	0.3	0.1
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.7	0.3	-0.5	-0.6	0.2	-0.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2	0.2	0.2
Progressive ratio	0.1	0.3	0.4	-0.5	0.5	-0.6	-0.6	0.4	0.3
Food seeking constrained by brief footshock	0.7	0.9	1.2	1.1	-1.0	0.9	0.8	-0.9	-0.8
Seeking ratio, punishment vs. effort	0.4	0.8	1.1	1.0	-0.9	0.9	1.0	-0.8	-0.6
Retroperitoneal fat weight	0.5	2.3	3.3	-1.8	1.4	-1.6	-1.7	1.3	1.0
Reaction time number correct	0.6	2.0	4.7	-2.2	1.3	-1.4	-1.6	1.0	0.6
Reaction time mean minus median	0.1	0.4	0.7	0.5	-0.7	0.6	0.5	-0.8	-0.9
Reaction time mean minus median AUC	0.0	0.1	0.2	0.4	-0.2	0.2	0.2	-0.1	-0.0
Reaction time num false alarms	0.5	0.8	1.5	-1.2	0.8	-0.9	-1.2	0.6	0.4
Reaction time num false alarms AUC	0.4	1.0	1.8	-1.3	0.9	-1.0	-1.3	0.7	0.4
Reaction time trials correct on left	0.6	2.0	4.7	-2.2	1.3	-1.4	-1.6	1.0	0.6
Reaction time trials on left	0.6	2.0	4.6	-2.1	1.3	-1.4	-1.6	1.0	0.6
Reaction time mean	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.0	0.3	0.3
Reaction time mean AUC	0.0	0.1	0.2	-0.1	0.3	-0.2	-0.1	0.3	0.4
Median of all reaction times	0.2	0.3	0.6	-0.3	0.6	-0.5	-0.3	0.7	0.8
Reaction time omissions	0.2	0.3	0.8	0.4	-0.4	0.7	0.9	-0.3	-0.2
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.4	0.3	0.2
Reaction time premature initiation rate	0.4	0.7	1.0	0.4	-0.8	0.9	0.8	-0.9	-1.0
Reaction time premature initiations	0.1	0.2	0.7	-0.7	-0.2	0.3	0.0	-0.5	-0.8
Std. dev. reaction times	0.0	0.1	0.1	0.3	-0.3	0.3	0.3	-0.3	-0.3
Reaction time trials completed	0.6	2.0	4.6	-2.1	1.3	-1.4	-1.6	1.0	0.6
Reaction time trials AUC	0.6	2.2	5.3	-2.3	1.3	-1.4	-1.7	1.0	0.6
Run reversals in cocaine runway, females	0.9	1.0	1.2	1.0	-1.0	1.0	1.1	-1.0	-0.9
Run reversals in cocaine runway, males	2.2	2.4	2.8	1.6	-1.6	1.5	1.7	-1.5	-1.4
Latency to leave start box in cocaine runway	0.5	0.7	1.5	1.1	-0.6	0.9	1.2	-0.5	-0.2
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	0.7	0.0	0.2	0.7	0.3	0.7
Latency to leave start box in cocaine runway, M	1.4	1.3	2.0	0.8	-1.2	1.1	1.0	-1.3	-1.4
Std. dev. time between licks in bursts	0.5	0.9	1.1	0.7	-1.0	1.0	1.0	-1.0	-0.9
Total sessions with >9 infusions	0.1	0.2	0.5	0.2	-0.4	0.2	-0.1	-0.5	-0.7
Short access day 1 total inactive lever presses	0.2	0.4	0.6	0.6	-0.7	0.6	0.4	-0.7	-0.8
Short access day 10 total inactive lever presses	0.0	0.1	0.3	-0.5	0.2	-0.4	-0.5	0.1	-0.0
Short access day 1 total infusions	0.3	0.5	0.6	0.8	-0.8	0.7	0.5	-0.8	-0.8
Short access day 10 total infusions	0.0	0.1	0.2	-0.0	-0.1	0.1	-0.3	-0.3	-0.5
Short access total infusions	0.2	0.2	0.4	0.5	-0.5	0.4	0.2	-0.6	-0.7
Short access day 1 locomotion	0.9	1.5	2.0	1.1	-1.2	1.2	0.9	-1.3	-1.4
Short access day 10 total locomotion	1.3	5.4	8.7	1.6	-2.3	2.2	1.8	-2.6	-3.0
Short access total locomotion	1.3	2.0	3.1	1.2	-1.4	1.4	1.1	-1.6	-1.8
One hour access (0.3 mA shock)	0.0	0.0	0.2	-0.1	0.2	-0.3	-0.4	0.1	-0.0
Compulsive drug intake	0.4	0.6	1.7	-0.3	0.8	-0.6	-0.3	1.0	1.3
One hour access (shock baseline)	0.1	0.3	0.9	0.3	-0.5	0.4	0.1	-0.7	-1.0
Social response proportion	1.1	1.4	2.0	1.2	-1.2	1.3	1.4	-1.1	-0.9
Social responses	7.6	10.0	10.4	3.2	-3.2	3.2	3.1	-3.2	-3.0
Social time	0.3	0.5	0.7	-0.7	0.7	-0.6	-0.6	0.8	0.9
Soleus weight	8.7	25.7	27.3	-4.6	5.2	-5.2	-5.1	5.2	5.1
Bone: stiffness	1.6	2.9	3.5	-1.0	1.7	-1.8	-1.8	1.8	1.9
Tibialis anterior weight	1.0	3.3	3.9	-1.8	1.8	-1.9	-2.0	1.8	1.7
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.2	0.5	-0.4	0.5	0.5	-0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.6	-0.2	-0.3	0.1	-0.2	-0.5	-0.8
Time to tail flick, test, before self-admin	0.4	0.5	0.9	0.9	-0.7	0.7	0.8	-0.6	-0.4
Time to tail flick, test, after self-admin	0.1	0.2	0.2	0.3	-0.4	0.3	0.3	-0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	-1.1	0.7	-0.9	-1.1	0.5	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.6	0.2	-0.3	-0.5	-0.0	-0.3
Tibia length	0.7	1.9	2.4	1.1	-1.4	1.3	1.2	-1.5	-1.6
Ambulatory time before self-admin	0.1	0.2	0.4	-0.4	0.5	-0.4	-0.3	0.5	0.6
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	-0.0	0.0	0.1	0.0	0.1
Bone: tissue strength	1.7	1.8	2.5	-1.0	1.4	-1.3	-1.1	1.5	1.6
Total heroin consumption	1.8	2.2	2.4	1.6	-1.5	1.5	1.5	-1.4	-1.3
Bone: trabecular number	0.7	1.4	3.0	1.7	-1.1	1.1	1.3	-0.9	-0.6
Bone: trabecular spacing	1.4	2.0	4.2	-2.0	1.3	-1.4	-1.7	0.9	0.5
Bone: trabecular thickness	0.5	0.7	1.7	1.3	-0.4	0.6	1.1	0.1	0.7
Bone: trabecular tissue density	1.1	2.0	2.7	-1.6	1.4	-1.4	-1.4	1.4	1.3
Water consumed over 24 hours	0.3	0.7	0.9	-0.6	0.8	-0.9	-0.8	0.9	0.9
Number of responses in last shaping day	1.0	1.2	2.2	0.8	-1.2	1.0	0.7	-1.3	-1.5