Fgd6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Fgd6 0.04 0.02 5.2e-04 0.02 0.02 0.02 0.02 4.1e-03 8.1e-04 3.5e-03 2.4e-03
2 Brain alternative TSS NM_001137645.1 0.04 0.02 7.7e-05 0.04 0.02 0.01 0.03 3.3e-04 3.1e-03 1.9e-02 2.0e-03
3 Brain alternative TSS XM_039079738.1 0.05 0.02 5.7e-05 0.04 0.02 0.02 0.03 2.0e-04 2.4e-03 7.5e-03 1.1e-03
4 Eye isoform ratio NM_001137645.1 0.54 0.15 1.9e-03 0.03 0.13 0.04 0.05 1.3e-01 4.7e-03 9.3e-02 6.0e-02
5 BLA gene expression Fgd6 0.08 0.04 1.1e-04 0.08 0.07 0.07 0.07 3.4e-05 1.5e-04 9.3e-05 1.2e-04
6 PL gene expression Fgd6 0.06 0.03 1.2e-07 0.08 0.06 0.07 0.08 3.0e-09 1.1e-07 1.1e-08 8.3e-09
7 Brain gene expression Fgd6 0.17 0.06 2.3e-15 0.2 0.18 0.19 0.19 6.5e-18 1.0e-16 3.5e-17 2.3e-17
8 Adipose gene expression Fgd6 0.07 0.06 9.5e-04 0.02 0.01 0.04 0.03 2.0e-03 7.1e-03 4.3e-05 1.8e-04
9 pVTA gene expression Fgd6 0.05 0.03 9.0e-03 0.03 0.01 -0 0 2.7e-02 1.3e-01 5.6e-01 2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.10.2-0.2-0.20.2-0.4-0.00.4-0.2-0.2-0.4
Area under the delay curve0.50.53.50.00.4-0.4-0.40.30.40.21.9-0.0
BMI with tail2.37.612.3-3.52.4-2.4-3.02.62.32.6-3.42.1
BMI without tail4.910.214.3-3.83.2-3.2-3.63.52.83.0-2.33.0
Body weight14.460.580.0-8.98.0-8.0-8.18.67.58.3-6.06.2
Weight adjusted by age0.70.83.4-0.90.7-0.7-0.70.90.30.6-0.51.8
Bone surface0.10.20.7-0.60.3-0.3-0.80.40.70.1-0.20.2
Bone volume0.30.51.1-0.90.5-0.5-1.10.60.80.5-0.40.3
Breakpoint value in progressive ratio session0.80.92.20.7-1.21.20.8-0.8-1.5-0.50.7-0.8
Number of licking bursts0.20.31.4-0.30.1-0.1-0.7-0.10.4-0.4-1.2-0.4
Context. condit. distance diff. score0.80.91.7-0.81.0-1.0-0.91.11.00.90.31.3
Locomotion velocity, session 10.40.41.20.5-0.70.71.1-0.6-1.0-0.50.1-0.1
Locomotion distance, session 10.10.10.3-0.50.2-0.20.00.1-0.10.4-0.50.4
Locomotion velocity, session 20.10.10.40.20.1-0.10.5-0.0-0.70.30.2-0.1
Locomotion distance, session 20.60.81.5-1.21.0-1.0-0.80.90.61.1-0.90.4
Locomotion velocity, session 30.30.41.7-0.60.4-0.40.40.4-0.40.6-0.21.3
Locomotion distance, session 31.01.12.1-1.21.1-1.1-0.71.20.61.1-0.81.5
Stereotopy head waving bouts, day 31.41.72.61.2-1.51.51.2-1.5-0.9-1.20.7-1.6
Stereotopy head waving duration, day 30.50.61.10.6-0.70.71.0-0.8-0.6-0.50.4-1.1
Locomotion velocity, session 71.01.13.0-1.11.1-1.1-0.21.10.11.1-1.01.7
Locomotion distance, session 70.40.51.1-0.70.8-0.8-0.10.90.10.7-0.61.1
Stereotopy head waving bouts, day 70.20.21.5-0.20.2-0.20.30.3-0.20.4-1.2-0.2
Stereotopy head waving duration, day 70.10.10.70.0-0.10.10.4-0.2-0.4-0.0-0.8-0.5
Locomotion velocity, session 80.70.81.4-0.71.0-1.0-0.71.00.41.20.51.2
Locomotion distance, session 83.85.67.2-2.62.5-2.5-2.32.62.02.6-0.92.7
Degree of sensitization distance0.20.20.30.5-0.20.20.5-0.3-0.5-0.40.4-0.6
Degree of sensitization stereotypy0.20.21.30.2-0.20.20.5-0.1-0.60.0-1.2-0.4
Conditioned locomotion0.10.10.3-0.1-0.10.10.50.20.30.3-0.1-0.0
Cocaine response after cond. corrected0.40.41.70.10.4-0.4-0.40.20.90.21.3-0.7
Cocaine response after cond. not corrected0.40.41.80.00.4-0.4-0.70.30.90.11.4-0.3
Cocaine response before conditioning0.10.10.60.1-0.30.3-0.3-0.0-0.2-0.50.10.8
Saline control response0.50.61.7-0.80.9-0.9-0.50.60.70.6-1.30.5
Bone: connectivity density0.50.71.20.8-1.11.10.4-0.9-0.5-1.10.4-1.0
Bone: cortical apparent density0.70.92.8-1.01.0-1.0-0.70.70.41.1-0.61.7
Bone: cortical area1.42.13.5-1.91.3-1.3-1.81.41.91.6-0.11.0
Bone: cortical porosity0.30.41.3-0.00.4-0.40.30.50.00.81.2-0.7
Bone: cortical porosity0.50.51.5-0.40.8-0.8-0.10.80.31.21.0-0.4
Bone: cortical thickness0.71.12.3-1.31.0-1.0-0.91.01.31.50.70.5
Bone: cortical thickness0.60.71.20.6-0.90.91.0-0.9-0.7-0.31.1-0.9
Bone: cortical tissue density0.70.93.0-0.91.0-1.0-0.60.60.31.0-0.61.7
Condit. Reinf. active minus inactive responses1.82.03.11.5-1.81.81.1-1.7-1.6-1.50.9-0.4
Condit. Reinf. active-inactive response ratio1.21.31.81.3-1.31.30.9-1.1-1.1-1.20.9-1.0
Condit. Reinf. active responses3.64.46.52.2-2.52.51.8-2.5-2.3-2.11.1-1.2
Condit. Reinf. inactive responses2.32.84.01.7-1.81.81.7-2.0-2.0-1.60.7-1.3
Incentive salience index mean0.40.50.90.7-1.01.00.3-0.9-0.9-0.80.30.1
Condit. Reinf. lever presses0.10.10.4-0.40.3-0.3-0.50.30.00.2-0.30.6
Condit. Reinf. active minus inactive responses0.20.20.90.0-0.00.00.2-0.0-0.90.0-0.90.2
Condit. Reinf. active-inactive response ratio0.10.10.5-0.20.2-0.2-0.30.1-0.20.2-0.70.0
Condit. Reinf. active responses0.20.31.00.0-0.10.10.3-0.1-1.00.0-1.00.4
Condit. Reinf. inactive responses0.60.82.20.9-0.80.81.1-0.8-1.5-0.70.90.2
Condit. Reinf. lever presses0.50.72.3-0.70.7-0.7-0.10.6-0.61.0-1.50.6
Condit. Reinf. lever reinforcers received0.20.31.7-0.20.0-0.00.2-0.0-0.90.2-1.30.7
Conditioned reinforcement - actives0.90.92.0-0.41.2-1.2-1.20.61.40.2-1.0-0.2
Conditioned reinforcement - inactives0.30.30.8-0.10.3-0.3-0.90.50.60.3-0.3-0.9
Conditioned locomotion1.41.72.5-1.01.5-1.5-1.61.51.41.1-1.30.5
Patch foraging indifference point 0 sec0.10.10.30.4-0.10.10.50.0-0.1-0.50.5-0.4
Patch foraging indifference point AUC0.20.20.6-0.20.0-0.0-0.4-0.20.5-0.7-0.8-0.2
Delay disc. indifference point, 0s delay0.10.10.2-0.0-0.40.4-0.3-0.2-0.30.10.1-0.3
Delay disc. indifference point, 16s delay0.50.51.0-0.50.9-0.9-0.60.51.00.51.0-0.2
Delay disc. indifference point, 2s delay0.70.81.1-0.90.8-0.8-0.91.00.91.0-0.11.0
Delay disc. indifference point, 24s delay1.11.12.1-1.01.0-1.0-1.10.91.00.61.51.3
Delay disc. indifference point, 4s delay0.30.32.50.30.3-0.30.30.00.10.01.6-0.5
Delay disc. indifference point, 8s delay0.70.86.00.5-0.10.10.1-0.1-0.1-0.22.5-0.7
Indifference point function ln k0.10.10.4-0.2-0.10.1-0.1-0.0-0.10.60.60.6
Indifference point function log k0.10.10.4-0.2-0.10.1-0.1-0.0-0.10.60.60.6
Patch foraging total patch changes 0 sec0.10.10.30.4-0.10.10.5-0.1-0.2-0.40.5-0.4
Patch foraging total patch changes 12 sec0.50.61.4-0.80.9-0.9-0.70.51.2-0.1-1.00.2
Patch foraging total patch changes 18 sec0.20.30.70.30.3-0.3-0.60.40.7-0.5-0.9-0.5
Patch foraging total patch changes 24 sec0.70.81.9-0.71.2-1.2-1.00.91.40.3-0.90.3
Patch foraging total patch changes 6 sec0.20.31.50.4-0.40.40.2-0.6-0.0-1.2-0.2-0.5
Patch foraging time to switch 0 sec0.20.30.70.30.7-0.70.40.60.20.6-0.0-0.9
Patch foraging water rate 0 sec1.32.04.2-1.80.9-0.9-2.10.71.70.7-1.12.0
Patch foraging water rate 12 sec2.64.06.5-2.31.8-1.8-2.31.62.51.6-2.51.1
Patch foraging water rate 18 sec0.30.42.9-0.5-0.10.1-0.3-0.00.2-0.2-1.70.1
Patch foraging water rate 24 sec5.27.29.3-2.92.9-2.9-3.12.23.02.6-1.92.4
Patch foraging water rate 6 sec7.310.713.8-3.73.3-3.3-3.53.03.22.9-3.33.1
Seeking ratio, delayed vs. immediate footshock0.20.20.70.0-0.20.20.00.1-0.10.60.8-0.8
Distance traveled before self-admin0.30.30.8-0.70.5-0.5-0.40.50.50.4-0.90.4
Distance traveled after self-admin0.70.71.6-1.31.0-1.0-0.51.00.41.0-0.60.6
Extensor digitorum longus weight0.10.40.7-0.60.3-0.3-0.70.60.80.80.0-0.5
Bone: elastic displacement4.04.59.22.2-1.81.82.4-1.9-2.2-1.63.0-1.6
Bone: elastic work2.73.510.11.7-1.61.62.0-1.7-1.7-1.23.2-1.2
Bone: endosteal estimation0.10.20.7-0.0-0.10.1-0.4-0.10.3-0.6-0.8-0.4
Bone: endosteal perimeter1.32.65.4-1.71.5-1.5-2.21.82.31.0-0.61.2
Epididymis fat weight4.09.316.9-3.62.9-2.9-2.82.62.62.6-4.13.0
Delta time in closed arm before/after self-admin0.40.40.8-0.60.1-0.1-0.60.80.70.9-0.6-0.2
Delta time in open arm before/after self-admin1.11.02.50.9-1.11.11.1-0.9-1.6-0.21.0-0.7
Diff in mean of infusions in LGA sessions1.61.73.71.2-1.21.21.9-1.0-1.4-0.61.0-1.8
Delay discount exponential model param0.50.63.50.1-0.60.60.4-0.4-0.6-0.3-1.9-0.1
Extinction: sum of active levers before priming0.20.20.60.4-0.40.40.4-0.5-0.2-0.00.3-0.8
Active lever presses in extinction session 60.20.20.5-0.70.5-0.5-0.30.30.20.6-0.20.0
Bone: final force0.40.61.5-1.10.6-0.6-1.00.71.20.8-0.3-0.1
Bone: final moment0.40.61.6-1.10.7-0.7-0.90.71.20.8-0.2-0.2
Food consumed during 24 hour testing period0.30.41.2-0.60.5-0.5-0.60.50.40.4-1.10.6
Glucose0.20.30.9-0.3-0.70.7-0.1-0.70.3-0.0-1.00.1
Heart weight0.30.41.1-0.50.8-0.8-0.40.6-0.31.00.60.0
Delay discount hyperbolic model param0.50.63.20.2-0.60.60.5-0.5-0.6-0.5-1.8-0.2
Intermittent access intake day 1-15 change0.20.20.7-0.10.3-0.3-0.5-0.10.8-0.4-0.4-0.4
Intermittent access intake escalation0.30.30.8-0.00.4-0.4-0.60.10.9-0.5-0.5-0.6
Intermittent access intake escalation 20.30.31.40.5-0.40.40.2-1.20.2-0.80.4-0.4
Intermitt. access day 1 inactive lever presses2.93.19.42.0-1.61.61.7-0.9-1.8-0.81.4-3.1
Intermitt. access day 15 inactive lever presses0.91.02.80.5-1.51.50.9-0.4-1.70.30.60.0
Intermitt. access escalation Index1.41.22.21.0-1.51.51.1-1.3-1.2-0.80.7-0.0
Intermittent access day 1 total infusions3.84.35.7-1.82.3-2.3-2.12.42.22.2-1.61.6
Intermittent access day 15 total infusions3.54.06.6-1.82.2-2.2-2.12.12.61.5-2.01.3
Intermittent access terminal intake (last 3 days)3.74.06.2-1.92.1-2.1-2.21.72.51.8-1.61.8
Intermittent access total infusions4.24.76.9-1.92.4-2.4-2.52.22.62.0-1.81.6
Intermittent access day 1 locomotion2.22.34.0-1.21.8-1.8-1.22.01.71.7-1.10.6
Intermittent access day 15 total locomotion2.12.23.5-1.11.7-1.7-1.71.91.71.3-1.10.6
Intermittent access total locomotion2.32.63.7-1.31.9-1.9-1.71.91.81.8-1.10.7
Intermittent access standard deviation1.51.64.0-1.01.5-1.5-1.50.52.00.7-1.40.1
Left kidney weight4.312.115.8-4.03.9-3.9-3.63.33.03.7-2.92.9
Right kidney weight2.77.710.6-3.33.1-3.1-2.72.72.32.8-2.42.4
Cocaine induced anxiety1.21.32.41.0-1.51.51.1-1.2-1.6-1.00.70.3
Post-drug Anxiety0.91.01.90.9-1.11.11.4-1.0-1.4-0.40.80.2
Baseline Anxiety0.10.10.3-0.20.4-0.40.10.30.50.4-0.2-0.2
Tail length9.729.340.4-5.95.9-5.9-5.56.45.15.6-2.45.2
Length with tail15.155.271.9-8.17.9-7.9-7.58.57.18.0-4.36.8
Length without tail8.017.524.3-4.64.4-4.4-4.14.73.94.9-2.73.5
Times rat made contact with spout2.02.36.7-1.40.7-0.7-2.60.72.20.4-2.30.3
Lifetime Intake3.84.35.7-1.82.3-2.3-2.32.02.41.8-1.62.0
Liver weight, left1.01.62.5-1.51.3-1.3-1.01.31.11.2-0.91.6
Liver weight, right1.62.64.6-1.81.8-1.8-1.22.10.82.0-1.21.4
Locomotor activity5.79.113.2-3.63.2-3.2-3.13.02.73.1-2.32.8
Locomotor testing distance2.74.56.0-2.42.5-2.5-2.22.01.82.0-1.61.8
Locomotor testing rearing0.50.81.6-0.71.3-1.3-0.71.10.80.80.40.4
Locomotion in novel chamber0.30.41.5-0.60.5-0.5-0.30.5-0.10.60.31.2
Locomotion in novel chamber post-restriction0.20.20.4-0.10.6-0.6-0.30.60.50.3-0.0-0.5
Fecal boli incidents, locomotor time 10.30.40.9-0.40.7-0.7-0.21.00.41.0-0.0-0.1
Change in fecal boli incidents, locomotor task1.00.91.51.0-1.21.20.9-1.1-1.0-1.20.10.2
Time >=10cm from walls, locomotor time 10.70.71.30.8-0.80.80.7-1.0-1.1-0.61.1-0.1
Bouts of movement, locomotor time 10.40.51.00.4-0.80.80.4-0.4-0.8-0.61.0-0.6
Total resting periods, locomotor time 10.70.81.40.6-1.11.10.6-0.5-1.1-0.61.2-0.6
Rest time, locomotor task time 11.82.03.11.2-1.71.71.5-1.4-1.6-1.41.0-0.8
Distance moved, locomotor task time 10.80.81.4-0.71.2-1.2-1.20.40.90.7-1.00.6
Vertical activity count, locomotor time 13.84.04.7-2.12.2-2.2-2.11.92.01.9-1.81.9
Time >=10cm from walls, locomotor time 20.40.41.00.9-0.40.40.3-1.0-0.5-0.90.7-0.3
Bouts of movement, locomotor time 20.30.42.2-0.30.1-0.1-0.10.5-0.00.71.50.5
Total resting periods, locomotor time 20.40.42.7-0.1-0.20.2-0.00.2-0.30.41.70.6
Rest time, locomotor task time 21.41.62.81.2-1.71.71.0-1.1-1.6-1.21.0-0.6
Distance moved, locomotor task time 20.70.81.8-0.71.2-1.2-0.70.31.00.6-1.30.1
Vertical activity count, locomotor time 26.77.38.8-2.83.0-3.0-2.52.72.92.8-2.91.2
Light reinforcement 10.81.56.6-1.30.1-0.1-1.1-0.10.40.2-2.61.9
Light reinforcement 20.60.81.40.7-1.01.00.7-1.1-0.7-1.2-0.9-0.8
Bone: marrow area0.10.20.6-0.1-0.10.1-0.5-0.00.4-0.6-0.8-0.4
Bone: maximum diameter1.73.25.4-2.21.5-1.5-2.31.72.31.6-1.31.3
Bone: maximum force0.10.20.5-0.60.1-0.1-0.70.40.50.60.3-0.2
Bone: maximum moment0.10.20.4-0.60.2-0.2-0.70.40.50.50.5-0.2
Mean time between licks in bursts0.60.91.7-0.80.9-0.9-1.21.10.31.30.61.0
Mean num. licks in bursts0.00.10.2-0.0-0.30.3-0.4-0.10.40.1-0.10.1
Cd content in liver1.51.72.9-1.11.7-1.7-1.51.70.81.3-0.80.5
Co content in liver2.73.14.1-1.72.0-2.0-1.71.82.01.9-0.81.6
Cu content in liver1.31.52.6-1.41.4-1.4-0.41.41.11.2-1.60.4
Fe content in liver0.70.81.4-0.91.0-1.0-0.81.21.00.9-0.40.6
K content in liver0.30.31.40.5-0.00.01.2-0.1-0.4-0.10.2-0.8
Mg content in liver0.40.41.10.6-0.40.41.0-0.5-0.9-0.60.1-0.3
Mn content in liver0.00.00.2-0.00.2-0.20.4-0.10.0-0.0-0.3-0.1
Na content in liver0.00.00.2-0.0-0.10.10.1-0.10.40.2-0.3-0.0
Rb content in liver1.01.22.91.4-0.60.61.3-0.8-0.4-0.71.6-1.7
Se content in liver0.70.82.8-0.70.9-0.90.20.9-0.00.7-1.71.1
Sr content in liver0.20.10.3-0.40.6-0.6-0.30.40.20.30.1-0.4
Zn content in liver0.40.40.9-0.60.7-0.7-0.20.9-0.20.8-0.10.9
Bone: minimum diameter3.66.811.3-3.12.3-2.3-3.42.53.02.3-1.82.4
Time in familiar zone, hab. session 10.10.10.4-0.20.4-0.40.20.6-0.4-0.0-0.20.3
Time in novel zone, hab. session 11.11.12.31.2-1.11.10.6-1.5-0.4-1.00.7-1.1
Total zone transitions, hab. session 13.34.76.6-2.62.1-2.1-2.51.91.92.2-1.82.3
Total locomotion distance, hab. session 13.75.37.0-2.62.4-2.4-2.52.11.62.0-2.52.5
Locomotion velocity, hab. session 14.66.68.9-3.02.5-2.5-2.92.21.82.2-2.72.9
Time in familiar zone, hab. session 20.00.10.2-0.2-0.10.1-0.00.1-0.40.4-0.1-0.1
Time in novel zone, hab. session 20.30.30.80.7-0.30.30.4-0.5-0.5-0.90.7-0.4
Total zone transitions, hab. session 20.70.91.4-1.01.2-1.2-1.00.90.31.0-0.61.0
Total locomotion distance, hab. session 20.60.81.4-1.00.9-0.9-1.20.60.30.7-1.10.8
Locomotion velocity, hab. session 20.60.91.3-1.01.0-1.0-1.20.70.40.7-1.01.0
Novel to familiar place preference ratio0.40.40.9-0.10.9-0.9-0.20.9-0.40.50.30.8
Novelty place preference0.40.40.70.20.8-0.80.10.8-0.70.40.50.6
Time in novel zone, NPP test0.40.40.80.00.9-0.9-0.00.9-0.60.50.40.7
Total zone transitions, NPP test1.21.72.6-1.61.4-1.4-1.21.30.71.6-0.31.3
Total locomotion distance, NPP test1.01.32.1-1.41.0-1.0-1.21.00.61.1-1.41.3
Locomotion velocity, NPP test0.50.71.5-1.10.7-0.7-0.90.70.40.7-1.21.1
Intraocular pressure1.62.24.81.6-1.81.80.7-2.2-0.7-1.60.4-1.7
Delta distance traveled before/after self-admin0.10.10.3-0.50.4-0.4-0.10.40.10.2-0.2-0.1
Delta ambulatory time before/after self-admin0.20.20.40.2-0.30.30.6-0.2-0.5-0.30.4-0.6
Parametrial fat weight0.10.30.70.0-0.70.70.8-0.5-0.5-0.10.20.3
Pavlov. Cond. lever latency0.60.71.1-0.81.0-1.0-0.81.00.80.9-0.00.8
Pavlov. Cond. magazine entry latency0.20.30.60.4-0.80.8-0.2-0.5-0.8-0.3-0.00.1
Pavlov. Cond. change in total contacts0.50.50.90.6-0.90.90.1-0.7-0.3-0.9-0.9-0.7
Pavlov. Cond. index score0.30.40.90.4-1.01.00.3-0.7-0.9-0.5-0.1-0.2
Pavlov. Cond. latency score0.40.51.00.4-1.01.00.3-0.8-0.9-0.6-0.3-0.4
Pavlov. Cond. lever contacts0.10.10.2-0.0-0.30.30.1-0.1-0.2-0.2-0.5-0.0
Pavlov. Cond. magazine entry number0.20.20.5-0.20.7-0.70.00.40.60.10.2-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.20.1-0.50.50.3-0.40.3-0.20.30.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.3-0.70.70.1-0.5-0.7-0.3-0.1-0.1
Pavlov. Cond. response bias0.10.20.40.2-0.60.6-0.1-0.4-0.3-0.3-0.50.1
Pavlov. Cond. lever latency0.30.41.50.5-0.40.40.3-0.30.3-0.61.2-0.9
Pavlov. Cond. magazine entry latency0.30.31.2-0.4-0.00.0-0.90.00.70.1-0.61.1
Pavlov. Cond. change in total contacts2.73.86.2-2.02.1-2.1-2.11.81.41.9-1.42.5
Pavlov. Cond. index score1.01.33.0-1.10.8-0.8-1.30.70.90.9-1.41.7
Pavlov. Cond. latency score0.60.82.4-0.80.6-0.6-0.90.50.60.7-1.21.6
Pavlov. Cond. lever contacts0.81.13.7-1.10.8-0.8-0.90.60.31.0-1.91.0
Pavlov. Cond. magazine entry number1.01.23.21.1-0.40.41.4-0.4-1.0-0.61.8-1.7
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.10.1-0.10.40.3-0.60.30.70.2
Pavlov. Cond. lever-magazine prob. diff.1.11.42.9-1.20.9-0.9-1.40.81.11.0-1.41.7
Pavlov. Cond. response bias1.11.53.7-1.31.0-1.0-1.40.90.71.1-1.91.3
Time in closed arm before self-admin0.40.41.3-0.50.7-0.7-0.90.20.10.3-0.21.1
Time in closed arm after self-admin1.01.01.3-1.01.1-1.1-1.00.91.00.8-1.20.7
Time in open arm before self-admin0.10.10.20.3-0.40.40.5-0.20.1-0.3-0.3-0.3
Time in open arm after self-admin0.91.01.80.9-1.21.20.9-0.6-1.30.11.2-0.8
Bone: periosteal estimation0.51.01.9-1.30.8-0.8-1.40.91.40.7-0.50.7
Bone: periosteal perimeter1.22.03.1-1.61.4-1.4-1.71.71.81.1-0.11.0
Bone: post-yield work0.20.31.6-0.4-0.30.3-0.60.10.50.1-1.3-0.5
Progressive ratio test 1 active lever presses9.19.614.5-2.83.7-3.7-3.13.13.82.4-3.11.6
Progressive ratio test 1 breakpoint8.69.013.1-2.83.5-3.5-3.03.03.62.4-3.01.7
Progressive ratio test 1 inactive lever presses0.40.41.2-0.50.5-0.5-0.61.10.50.8-0.5-0.2
Progressive ratio test 2 active lever presses3.33.55.2-1.62.2-2.2-2.01.82.31.6-1.81.2
Progressive ratio test 2 breakpoint3.53.96.4-1.82.2-2.2-2.21.82.51.7-1.91.2
Progressive ratio test 2 inactive lever presses0.40.51.0-0.60.6-0.6-0.70.80.90.6-1.00.1
Incentive Sensitization - Responses1.31.32.3-0.91.3-1.3-1.31.01.51.2-0.80.4
Incentive Sensitization - Breakpoint1.01.01.8-0.81.2-1.2-1.20.81.31.1-0.70.3
Sum of active levers in priming session hrs 5-60.20.20.6-0.50.4-0.4-0.80.10.30.1-0.80.1
Progressive ratio2.32.77.02.1-1.41.41.5-1.6-1.4-1.42.7-0.6
Food seeking constrained by brief footshock0.70.91.9-0.71.2-1.2-0.80.81.40.8-0.90.4
Seeking ratio, punishment vs. effort1.82.25.0-1.71.4-1.4-1.21.41.41.3-2.20.5
Retroperitoneal fat weight3.411.215.8-3.93.2-3.2-3.23.42.53.6-3.04.0
Reaction time number correct0.10.20.6-0.5-0.10.1-0.4-0.50.3-0.3-0.80.3
Reaction time mean minus median1.11.52.81.1-1.11.11.0-1.2-1.7-0.71.7-0.8
Reaction time mean minus median AUC1.31.73.31.3-1.41.41.1-1.3-1.8-0.71.5-0.9
Reaction time num false alarms1.11.52.71.3-0.90.91.6-0.8-1.1-1.11.2-1.5
Reaction time num false alarms AUC1.31.83.41.5-1.01.01.8-0.8-1.4-1.21.4-1.8
Reaction time trials correct on left0.10.20.6-0.5-0.10.1-0.4-0.50.3-0.3-0.80.3
Reaction time trials on left0.10.20.4-0.4-0.20.2-0.3-0.60.3-0.4-0.70.2
Reaction time mean0.10.10.30.2-0.20.2-0.0-0.4-0.30.10.5-0.4
Reaction time mean AUC0.00.10.30.1-0.00.0-0.2-0.1-0.10.30.5-0.4
Median of all reaction times0.10.20.3-0.40.5-0.5-0.60.30.40.6-0.3-0.0
Reaction time omissions2.23.14.21.9-1.21.22.0-1.9-1.9-2.01.8-1.5
Reaction time false alarm rate1.31.83.41.7-0.90.91.9-0.5-1.3-1.01.6-1.8
Reaction time premature initiation rate0.40.51.9-0.80.5-0.5-0.90.40.30.1-1.40.3
Reaction time premature initiations0.60.83.2-1.20.5-0.5-1.20.20.60.1-1.80.5
Std. dev. reaction times1.21.73.61.3-1.11.11.2-1.3-1.7-0.91.9-1.1
Reaction time trials completed0.10.20.4-0.4-0.20.2-0.3-0.60.3-0.4-0.70.2
Reaction time trials AUC0.10.20.7-0.5-0.10.1-0.4-0.60.4-0.3-0.80.3
Run reversals in cocaine runway, females0.70.71.4-1.11.0-1.0-0.60.81.01.20.20.4
Run reversals in cocaine runway, males0.30.21.8-0.1-0.30.30.20.0-0.40.0-1.30.0
Latency to leave start box in cocaine runway0.40.41.7-0.90.1-0.1-0.70.4-0.10.3-0.51.3
Latency to leave start box in cocaine runway, F0.50.51.20.1-0.80.80.5-0.6-0.9-0.7-1.10.5
Latency to leave start box in cocaine runway, M2.32.23.6-1.81.3-1.3-1.91.71.21.60.21.5
Std. dev. time between licks in bursts0.70.84.00.40.7-0.70.20.5-1.30.62.00.4
Total sessions with >9 infusions2.93.14.5-1.62.0-2.0-1.61.62.11.2-1.81.8
Short access day 1 total inactive lever presses0.30.32.00.5-0.20.20.2-0.00.20.00.6-1.4
Short access day 10 total inactive lever presses3.74.18.01.5-2.62.62.2-1.5-2.8-0.02.5-0.4
Short access day 1 total infusions2.12.23.5-1.41.4-1.4-1.51.41.91.7-0.71.7
Short access day 10 total infusions5.96.68.3-2.42.9-2.9-2.82.52.72.6-2.11.9
Short access total infusions4.95.56.6-2.32.5-2.5-2.52.12.62.3-1.92.3
Short access day 1 locomotion2.83.14.3-2.01.6-1.6-1.61.82.12.1-1.61.1
Short access day 10 total locomotion0.60.62.70.50.6-0.60.30.80.31.00.6-1.7
Short access total locomotion2.22.33.5-1.11.9-1.9-1.31.71.81.7-1.2-0.4
One hour access (0.3 mA shock)1.92.34.2-1.11.7-1.7-2.01.21.90.7-0.91.8
Compulsive drug intake2.22.23.71.1-1.91.91.3-1.6-1.9-1.11.60.4
One hour access (shock baseline)3.64.26.4-1.62.5-2.5-2.32.22.51.6-1.51.1
Social response proportion3.23.56.5-2.61.7-1.7-1.41.81.62.4-1.71.6
Social responses2.22.85.7-2.41.6-1.6-1.31.51.21.8-1.22.2
Social time0.91.24.7-1.30.8-0.8-0.70.31.30.7-2.2-0.8
Soleus weight0.10.30.9-1.00.3-0.3-0.50.40.60.5-0.50.1
Bone: stiffness2.13.35.0-2.21.8-1.8-1.92.01.82.0-1.70.5
Tibialis anterior weight0.20.61.90.6-0.70.70.5-0.6-0.4-0.51.1-1.4
Time to tail flick, vehicle, before self-admin2.32.46.8-1.41.4-1.4-2.61.32.00.8-1.21.0
Time to tail flick, vehicle, after self-admin1.31.43.61.5-0.80.81.5-0.7-1.0-0.81.0-1.9
Time to tail flick, test, before self-admin0.20.20.5-0.40.4-0.40.3-0.10.4-0.1-0.70.5
Time to tail flick, test, after self-admin0.20.20.70.0-0.40.4-0.0-0.80.4-0.8-0.40.4
Delta time to tail flick, vehicle, before/after SA3.63.67.42.0-1.71.72.7-1.6-2.1-1.31.7-1.8
Delta time to tail flick, test, before/after SA0.30.30.70.4-0.80.8-0.2-0.6-0.2-0.50.30.1
Tibia length10.730.237.8-6.15.7-5.7-6.05.85.45.4-3.75.3
Ambulatory time before self-admin0.60.71.5-0.91.0-1.0-0.40.70.80.6-1.20.3
Ambulatory time after self-admin1.21.32.7-1.61.2-1.2-0.61.30.61.2-0.71.0
Bone: tissue strength0.30.30.7-0.60.7-0.7-0.40.50.60.4-0.8-0.2
Total heroin consumption0.30.40.9-0.1-0.70.70.3-0.6-0.9-0.30.60.8
Bone: trabecular number0.61.01.60.8-1.31.30.4-1.2-0.4-1.30.3-1.1
Bone: trabecular spacing0.30.41.90.4-0.40.40.3-0.3-0.7-0.11.40.6
Bone: trabecular thickness0.80.92.0-1.20.8-0.8-0.71.20.60.9-1.40.4
Bone: trabecular tissue density0.10.10.6-0.20.1-0.10.20.10.00.3-0.80.5
Water consumed over 24 hours0.80.91.6-0.81.2-1.2-1.11.01.00.6-1.2-0.4
Number of responses in last shaping day0.60.61.2-0.60.9-0.9-0.70.91.10.6-0.70.5