Hub : Genes

Fgd6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Fgd6 0.04 0.03 1.9e-04 0.01 0.05 0.03 0.04 2.1e-02 5.4e-05 9.1e-04 5.3e-04
2 NAcc gene expression Fgd6 0.03 0.02 2.0e-05 0.01 0.02 0.01 0.01 5.2e-03 1.6e-04 2.4e-03 1.7e-03
3 BLA gene expression Fgd6 0.08 0.04 3.6e-05 0.09 0.07 0.07 0.07 1.9e-05 1.2e-04 1.6e-04 2.1e-04
4 IC gene expression Fgd6 0.07 0.05 6.7e-03 0.04 0.04 0.02 0.03 7.9e-03 7.5e-03 3.3e-02 1.5e-02
5 Eye gene expression Fgd6 0.45 0.2 9.6e-03 0.06 0.01 -0.02 0.02 4.6e-02 2.3e-01 9.1e-01 1.5e-01
6 Brain alternative TSS XM_039079738.2 0.05 0.03 5.5e-04 0.05 0.03 0.04 0.04 1.8e-05 1.5e-03 6.9e-05 8.2e-05
7 Brain gene expression Fgd6 0.16 0.06 1.6e-15 0.18 0.19 0.19 0.19 6.5e-17 2.1e-17 1.5e-17 1.3e-17
8 Brain alternative TSS XM_063264098.1 0.05 0.03 2.1e-03 0.03 0.02 0.01 0.03 4.2e-04 3.3e-03 3.5e-02 1.2e-03
9 PL gene expression Fgd6 0.05 0.03 4.7e-07 0.07 0.06 0.06 0.07 1.3e-08 6.3e-07 5.4e-07 2.9e-08
10 Adipose gene expression Fgd6 0.07 0.05 8.9e-04 0.03 0.01 0.03 0.04 1.4e-04 7.6e-03 1.6e-04 7.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.10.3-0.0-0.10.10.50.0-0.10.30.1-0.50.4
Area under the delay curve0.20.20.9-0.3-0.2-0.4-0.6-0.40.2-0.4-0.1-0.5-1.0
BMI with tail3.211.215.4-3.9-3.9-3.3-2.6-3.03.2-3.6-3.1-2.83.7
BMI without tail5.216.019.3-4.4-4.4-4.1-3.3-4.24.2-4.2-4.2-3.73.0
Body weight16.170.585.9-9.3-9.2-8.9-7.9-8.08.7-8.9-8.6-7.76.5
Weight adjusted by age0.10.20.4-0.6-0.5-0.4-0.30.50.6-0.4-0.6-0.30.3
Bone surface0.20.41.1-0.7-0.7-0.5-0.5-1.10.3-0.2-0.3-0.90.6
Bone volume0.30.61.1-0.9-1.0-0.6-0.4-0.90.5-0.4-0.6-1.10.8
Breakpoint value in progressive ratio session0.80.92.60.60.80.71.31.6-0.40.40.51.5-0.8
Number of licking bursts0.20.31.2-0.3-0.3-0.40.4-0.90.00.5-0.1-0.51.1
Context. condit. distance diff. score0.70.92.1-0.9-0.9-0.9-1.5-0.80.9-1.0-0.9-0.90.2
Locomotion velocity, session 10.60.62.00.60.70.70.71.4-0.80.50.81.0-0.5
Locomotion distance, session 10.10.20.6-0.6-0.5-0.0-0.30.30.1-0.4-0.10.00.8
Locomotion velocity, session 20.20.20.50.30.30.10.50.7-0.2-0.30.20.6-0.6
Locomotion distance, session 20.81.12.0-1.2-1.2-1.0-0.8-0.61.1-1.2-1.1-0.71.4
Locomotion velocity, session 30.30.30.9-0.6-0.5-0.4-0.61.00.4-0.7-0.40.40.4
Locomotion distance, session 31.21.31.7-1.3-1.2-1.2-1.2-0.31.3-1.2-1.2-0.51.3
Stereotopy head waving bouts, day 31.61.92.61.41.51.61.61.1-1.61.31.61.0-0.9
Stereotopy head waving duration, day 30.50.71.00.80.80.80.91.0-0.90.60.90.6-0.6
Locomotion velocity, session 70.70.71.4-0.9-0.8-1.1-0.80.21.1-1.2-1.1-0.30.5
Locomotion distance, session 70.30.40.6-0.7-0.7-0.8-0.70.20.7-0.8-0.7-0.20.7
Stereotopy head waving bouts, day 70.20.20.60.20.2-0.20.80.70.2-0.1-0.20.40.6
Stereotopy head waving duration, day 70.20.20.70.20.2-0.10.80.70.0-0.0-0.10.50.6
Locomotion velocity, session 80.50.61.4-0.8-0.8-0.9-0.9-0.00.9-1.2-0.9-0.4-0.2
Locomotion distance, session 84.05.78.0-2.7-2.6-2.4-2.8-1.82.5-2.6-2.5-2.01.8
Degree of sensitization distance0.30.30.50.60.60.40.60.4-0.50.50.50.4-0.7
Degree of sensitization stereotypy0.30.30.90.40.2-0.20.90.90.20.0-0.20.60.7
Conditioned locomotion0.00.00.10.00.1-0.0-0.20.20.1-0.3-0.1-0.1-0.3
Cocaine response after cond. corrected0.20.31.0-0.1-0.2-0.3-0.4-0.90.4-0.1-0.3-1.0-0.6
Cocaine response after cond. not corrected0.30.31.1-0.3-0.3-0.3-0.6-1.10.3-0.1-0.3-1.0-0.4
Cocaine response before conditioning0.00.00.1-0.10.00.3-0.20.1-0.30.30.30.20.2
Saline control response0.30.51.1-0.6-0.8-0.6-0.6-0.90.5-0.4-0.5-0.41.1
Bone: connectivity density0.50.71.40.80.71.01.10.5-1.01.21.00.4-0.2
Bone: cortical apparent density0.20.30.6-0.7-0.6-0.5-0.8-0.20.4-0.7-0.5-0.00.2
Bone: cortical area1.82.84.0-2.0-1.9-1.6-1.8-1.81.4-1.7-1.4-1.81.1
Bone: cortical porosity0.30.30.7-0.1-0.2-0.7-0.2-0.30.8-0.8-0.9-0.1-0.8
Bone: cortical porosity0.40.41.1-0.2-0.3-0.8-0.4-0.40.8-1.0-0.9-0.2-0.8
Bone: cortical thickness1.01.62.8-1.4-1.3-1.2-1.6-1.11.2-1.7-1.1-1.20.2
Bone: cortical thickness0.50.62.00.70.80.70.70.6-0.70.10.70.8-1.4
Bone: cortical tissue density0.20.30.7-0.8-0.6-0.5-0.8-0.30.5-0.7-0.5-0.00.2
Condit. Reinf. active minus inactive responses2.02.32.91.41.51.61.31.7-1.71.51.71.6-1.0
Condit. Reinf. active-inactive response ratio1.41.51.91.31.31.11.31.4-1.21.21.21.1-0.9
Condit. Reinf. active responses4.15.06.42.22.22.52.22.1-2.52.32.52.2-1.5
Condit. Reinf. inactive responses2.73.34.11.81.82.01.91.5-2.01.82.01.9-1.2
Incentive salience index mean0.50.61.00.60.70.80.71.0-0.90.90.90.9-0.3
Condit. Reinf. lever presses0.10.10.2-0.4-0.4-0.4-0.10.00.30.0-0.3-0.10.3
Condit. Reinf. active minus inactive responses0.20.31.20.20.1-0.00.81.1-0.0-0.00.10.80.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.1-0.3-0.30.20.40.2-0.3-0.10.10.7
Condit. Reinf. active responses0.20.21.10.10.10.10.71.0-0.10.00.20.80.3
Condit. Reinf. inactive responses0.81.02.10.71.00.80.91.2-0.80.70.71.4-1.4
Condit. Reinf. lever presses0.30.40.7-0.3-0.3-0.70.70.90.7-0.8-0.60.60.4
Condit. Reinf. lever reinforcers received0.20.21.0-0.2-0.1-0.10.51.00.0-0.20.00.70.6
Conditioned reinforcement - actives0.20.30.7-0.1-0.2-0.8-0.2-0.50.60.4-0.6-0.80.6
Conditioned reinforcement - inactives0.10.10.20.50.40.10.5-0.20.00.4-0.00.1-0.2
Conditioned locomotion0.40.51.1-0.5-0.6-0.7-0.6-0.80.9-0.2-1.0-0.60.4
Patch foraging indifference point 0 sec0.10.10.50.40.4-0.00.4-0.1-0.00.60.00.1-0.7
Patch foraging indifference point AUC0.10.20.8-0.2-0.3-0.10.1-0.70.10.5-0.0-0.60.9
Delay disc. indifference point, 0s delay0.10.10.80.10.10.50.90.6-0.10.10.10.2-0.1
Delay disc. indifference point, 16s delay0.40.51.0-0.7-0.6-0.8-0.9-0.90.4-0.6-0.4-1.00.0
Delay disc. indifference point, 2s delay1.01.12.1-1.2-1.1-0.9-1.4-0.71.1-1.3-0.9-1.00.7
Delay disc. indifference point, 24s delay1.01.13.2-1.4-1.2-0.8-1.8-0.90.6-1.0-0.7-1.0-0.1
Delay disc. indifference point, 4s delay0.20.21.50.20.3-0.1-0.3-0.2-0.2-0.00.3-0.2-1.2
Delay disc. indifference point, 8s delay0.30.43.10.30.40.10.1-0.0-0.20.10.30.0-1.8
Indifference point function ln k0.10.10.5-0.3-0.2-0.0-0.30.10.1-0.7-0.10.0-0.7
Indifference point function log k0.10.10.5-0.3-0.2-0.0-0.30.10.1-0.7-0.10.0-0.7
Patch foraging total patch changes 0 sec0.10.20.70.40.40.20.4-0.1-0.10.60.10.3-0.8
Patch foraging total patch changes 12 sec0.40.51.2-0.6-0.7-0.6-0.3-1.10.50.0-0.4-1.00.9
Patch foraging total patch changes 18 sec0.20.31.20.30.1-0.40.3-1.10.30.8-0.3-0.50.2
Patch foraging total patch changes 24 sec0.40.82.1-0.7-0.8-0.9-0.7-1.50.8-0.2-0.7-1.20.8
Patch foraging total patch changes 6 sec0.30.52.10.60.50.60.8-0.3-0.71.40.80.1-0.0
Patch foraging time to switch 0 sec0.00.10.20.40.3-0.5-0.00.00.4-0.3-0.4-0.1-0.2
Patch foraging water rate 0 sec1.12.23.9-2.0-1.9-0.9-1.7-1.90.9-1.0-0.8-1.71.5
Patch foraging water rate 12 sec1.94.06.5-2.1-2.3-1.5-1.5-2.31.6-1.5-1.6-2.42.6
Patch foraging water rate 18 sec0.30.43.3-0.5-0.60.1-0.0-0.20.00.2-0.0-0.31.8
Patch foraging water rate 24 sec5.37.59.9-3.1-3.1-2.6-3.0-2.52.4-2.7-2.4-3.02.3
Patch foraging water rate 6 sec6.69.613.0-3.6-3.6-2.9-2.9-3.03.0-2.9-3.0-3.13.0
Seeking ratio, delayed vs. immediate footshock0.10.10.50.00.10.20.3-0.10.2-0.5-0.30.0-0.7
Distance traveled before self-admin0.91.12.4-1.4-1.3-1.0-1.1-0.40.8-1.0-1.2-0.51.6
Distance traveled after self-admin0.30.40.8-0.8-0.5-0.4-0.50.80.8-0.9-0.90.30.3
Extensor digitorum longus weight0.20.61.1-0.7-0.8-0.8-0.4-1.10.7-0.9-0.7-1.00.5
Bone: elastic displacement3.44.06.22.12.11.81.62.5-1.71.61.72.0-2.4
Bone: elastic work1.92.56.01.61.71.41.01.8-1.41.01.31.6-2.5
Bone: endosteal estimation0.10.20.7-0.1-0.1-0.00.3-0.6-0.10.60.1-0.50.8
Bone: endosteal perimeter1.53.15.4-1.9-1.8-1.7-1.9-2.21.5-1.1-1.5-2.31.3
Epididymis fat weight3.110.515.6-4.0-3.8-3.3-3.0-2.73.1-3.1-2.9-2.73.5
Delta time in closed arm before/after self-admin0.70.71.0-0.6-0.7-0.8-0.8-0.80.9-0.9-0.7-0.81.0
Delta time in open arm before/after self-admin2.32.34.61.41.41.42.21.8-0.90.60.71.8-2.0
Diff in mean of infusions in LGA sessions0.20.21.00.50.50.20.41.00.0-0.20.10.5-0.5
Delay discount exponential model param0.30.30.80.40.30.50.80.5-0.30.50.20.60.9
Extinction: sum of active levers before priming0.10.10.2-0.1-0.2-0.2-0.00.20.5-0.3-0.4-0.10.4
Active lever presses in extinction session 60.30.30.6-0.7-0.7-0.2-0.30.50.5-0.8-0.60.10.3
Bone: final force0.30.51.0-0.8-0.8-0.5-0.5-1.00.3-0.5-0.3-1.00.9
Bone: final moment0.30.51.1-0.8-0.9-0.6-0.6-1.00.4-0.6-0.3-1.00.9
Food consumed during 24 hour testing period0.30.40.7-0.7-0.7-0.8-0.5-0.90.3-0.3-0.4-0.40.7
Glucose0.20.30.9-0.00.01.00.40.1-0.70.10.70.10.9
Heart weight1.11.83.2-1.8-1.7-1.5-1.0-1.31.1-1.4-1.0-0.91.2
Delay discount hyperbolic model param0.40.51.10.50.50.71.00.6-0.50.70.30.70.9
Intermittent access intake day 1-15 change0.40.91.7-1.0-0.9-0.7-1.1-1.10.7-0.7-0.7-0.91.3
Intermittent access intake escalation0.40.81.2-1.0-0.9-0.5-1.1-1.10.7-0.8-0.8-0.91.1
Intermittent access intake escalation 20.30.30.9-0.7-0.6-0.1-1.0-0.60.1-0.7-0.1-0.40.6
Intermitt. access day 1 inactive lever presses0.93.37.02.72.41.32.21.3-1.01.81.01.8-1.8
Intermitt. access day 15 inactive lever presses0.10.20.60.00.10.20.00.80.5-0.7-0.50.7-0.1
Intermitt. access escalation Index0.10.20.50.20.20.70.10.6-0.40.30.60.2-0.3
Intermittent access day 1 total infusions1.62.63.9-1.2-1.4-2.0-1.6-1.61.9-1.4-1.8-1.91.3
Intermittent access day 15 total infusions2.33.44.3-1.7-1.8-1.5-2.1-1.82.0-1.7-2.0-1.91.7
Intermittent access terminal intake (last 3 days)2.53.24.7-1.7-1.8-1.6-2.2-1.81.9-1.8-1.9-1.81.5
Intermittent access total infusions2.42.84.1-1.4-1.5-1.7-1.8-1.72.0-1.5-2.0-1.81.3
Intermittent access day 1 locomotion0.91.12.2-0.4-0.6-1.3-1.0-1.01.5-0.8-1.5-1.30.1
Intermittent access day 15 total locomotion0.30.50.9-0.3-0.4-0.9-0.8-0.80.9-0.5-1.0-0.60.2
Intermittent access total locomotion1.41.63.2-0.8-0.9-1.5-1.3-1.41.8-1.2-1.8-1.20.4
Intermittent access standard deviation0.40.92.9-0.5-0.7-0.6-1.1-1.70.5-0.2-0.6-1.21.4
Left kidney weight4.922.832.9-5.7-5.6-4.5-4.9-4.44.4-5.0-4.3-4.44.2
Right kidney weight4.219.326.8-5.2-5.1-4.4-4.2-4.14.2-4.3-4.1-4.04.1
Cocaine induced anxiety1.31.93.91.11.21.31.42.0-1.30.71.31.7-1.4
Post-drug Anxiety0.60.73.00.50.60.60.71.7-0.80.30.81.0-0.4
Baseline Anxiety2.02.33.5-1.4-1.5-1.7-1.7-1.21.5-1.1-1.4-1.61.9
Tail length10.540.846.4-6.7-6.7-6.7-6.8-6.66.8-6.4-6.8-6.33.2
Length with tail15.968.978.9-8.9-8.9-8.9-8.6-8.18.7-8.5-8.6-7.95.5
Length without tail9.330.136.4-6.0-6.0-5.9-5.5-4.95.6-5.8-5.5-4.84.4
Times rat made contact with spout2.42.87.5-1.4-1.6-1.3-1.0-2.70.5-0.3-0.5-2.22.7
Lifetime Intake2.22.73.5-1.5-1.6-1.7-1.9-1.81.7-1.4-1.7-1.91.3
Liver weight, left6.610.914.5-3.1-3.3-3.6-3.4-3.73.4-2.5-3.2-3.82.7
Liver weight, right5.19.011.9-3.1-3.1-3.4-2.7-2.83.4-3.4-3.3-2.61.8
Locomotor activity5.89.113.1-3.6-3.5-2.9-3.0-2.82.8-3.2-2.8-2.62.8
Locomotor testing distance3.05.47.5-2.7-2.6-2.4-2.3-2.32.2-2.5-2.2-1.92.2
Locomotor testing rearing0.51.01.8-1.0-0.8-1.1-1.4-1.21.0-1.1-0.9-0.80.0
Locomotion in novel chamber0.40.51.3-0.9-0.7-0.5-1.2-0.50.7-0.9-0.60.0-0.1
Locomotion in novel chamber post-restriction0.20.30.7-0.3-0.3-0.4-0.5-0.90.7-0.3-0.6-0.50.5
Fecal boli incidents, locomotor time 10.30.51.2-0.3-0.2-1.1-0.2-0.31.0-0.8-1.0-0.5-0.3
Change in fecal boli incidents, locomotor task1.51.52.31.11.11.50.71.4-1.41.41.51.3-0.3
Time >=10cm from walls, locomotor time 10.90.91.60.90.81.30.90.6-0.90.90.61.2-1.2
Bouts of movement, locomotor time 10.40.51.60.50.50.11.30.7-0.40.80.60.8-0.7
Total resting periods, locomotor time 10.80.91.90.70.80.51.41.1-0.60.90.71.1-1.0
Rest time, locomotor task time 12.02.53.61.41.51.61.71.9-1.51.61.71.5-1.3
Distance moved, locomotor task time 10.81.22.9-1.1-1.1-0.7-1.1-1.70.7-1.0-0.9-1.11.1
Vertical activity count, locomotor time 12.25.46.4-2.5-2.5-2.2-2.5-2.52.2-2.2-2.3-2.12.1
Time >=10cm from walls, locomotor time 20.60.91.60.90.91.01.21.1-0.81.30.70.6-0.8
Bouts of movement, locomotor time 20.20.31.1-0.4-0.2-0.2-0.50.30.4-0.8-0.50.1-1.0
Total resting periods, locomotor time 20.10.21.7-0.10.10.1-0.10.60.1-0.4-0.20.4-1.3
Rest time, locomotor task time 21.31.62.21.21.31.21.41.4-1.21.31.21.5-1.0
Distance moved, locomotor task time 20.60.71.2-0.8-0.9-0.5-0.5-1.00.5-0.7-0.8-1.01.1
Vertical activity count, locomotor time 25.57.59.0-2.8-2.9-2.9-2.0-2.63.0-2.7-3.0-2.92.7
Light reinforcement 10.41.16.5-1.3-1.30.1-0.5-0.30.1-0.4-0.1-0.32.6
Light reinforcement 20.50.81.60.90.71.11.20.5-0.91.30.80.70.6
Bone: marrow area0.10.20.6-0.1-0.1-0.00.4-0.6-0.10.60.1-0.40.8
Bone: maximum diameter2.24.15.6-2.4-2.2-1.9-2.0-2.21.7-1.8-1.7-2.31.8
Bone: maximum force0.10.20.4-0.6-0.6-0.4-0.3-0.50.2-0.5-0.2-0.50.4
Bone: maximum moment0.10.20.4-0.6-0.6-0.5-0.3-0.40.3-0.5-0.3-0.50.3
Mean time between licks in bursts0.10.30.8-0.6-0.4-0.2-0.5-0.20.7-0.9-0.70.1-0.6
Mean num. licks in bursts0.10.10.2-0.1-0.10.2-0.5-0.4-0.3-0.20.4-0.30.4
Cd content in liver0.10.10.70.10.1-0.40.80.30.5-0.1-0.40.3-0.0
Co content in liver0.10.20.5-0.5-0.2-0.4-0.7-0.20.2-0.4-0.2-0.1-0.6
Cu content in liver0.20.30.9-0.4-0.4-0.9-0.1-0.40.6-0.6-0.6-0.50.4
Fe content in liver0.70.81.7-0.7-0.8-1.3-0.8-0.41.2-1.1-1.2-0.70.0
K content in liver0.20.20.90.50.5-0.00.3-0.5-0.10.10.00.0-0.9
Mg content in liver0.90.91.61.01.10.80.90.4-0.90.90.91.1-1.3
Mn content in liver0.00.00.20.10.20.20.1-0.2-0.10.10.10.4-0.2
Na content in liver0.10.10.3-0.1-0.2-0.20.0-0.00.3-0.5-0.3-0.5-0.3
Rb content in liver1.41.66.71.61.50.90.90.4-0.90.90.80.7-2.6
Se content in liver0.20.20.4-0.1-0.1-0.60.10.60.6-0.4-0.60.30.0
Sr content in liver0.10.10.7-0.4-0.4-0.0-0.00.20.2-0.1-0.2-0.20.8
Zn content in liver2.73.04.1-1.9-1.9-2.0-1.7-1.61.9-1.7-1.9-1.11.3
Bone: minimum diameter4.68.411.6-3.4-3.3-2.6-2.9-3.12.5-2.6-2.6-3.02.8
Time in familiar zone, hab. session 10.20.20.60.00.0-0.70.40.70.60.0-0.60.40.1
Time in novel zone, hab. session 11.01.01.91.21.11.40.7-0.1-1.31.01.30.4-0.8
Total zone transitions, hab. session 13.24.46.5-2.5-2.4-2.2-1.8-1.12.2-2.3-2.2-1.82.1
Total locomotion distance, hab. session 13.55.08.9-2.7-2.6-2.3-1.8-0.92.3-2.2-2.3-1.53.0
Locomotion velocity, hab. session 14.56.311.1-3.1-3.0-2.5-2.1-1.22.5-2.5-2.5-1.83.3
Time in familiar zone, hab. session 20.10.10.3-0.1-0.2-0.2-0.0-0.00.4-0.5-0.40.30.0
Time in novel zone, hab. session 20.50.50.90.80.70.50.80.7-0.81.00.80.5-0.5
Total zone transitions, hab. session 20.60.81.5-1.2-1.0-0.9-0.9-0.10.9-1.1-0.9-0.21.0
Total locomotion distance, hab. session 20.60.72.7-1.1-1.0-0.7-0.6-0.20.7-0.7-0.7-0.31.7
Locomotion velocity, hab. session 20.60.82.5-1.3-1.1-0.7-0.8-0.20.8-0.8-0.7-0.41.6
Novel to familiar place preference ratio0.20.20.6-0.1-0.1-0.80.00.40.6-0.4-0.60.4-0.4
Novelty place preference0.30.30.50.20.2-0.70.30.70.5-0.2-0.50.7-0.7
Time in novel zone, NPP test0.20.30.70.00.0-0.80.20.60.6-0.4-0.60.6-0.6
Total zone transitions, NPP test1.21.73.1-1.7-1.5-1.3-1.4-0.81.4-1.7-1.4-0.70.8
Total locomotion distance, NPP test1.11.53.2-1.6-1.5-1.0-1.2-0.81.0-1.3-1.0-0.71.8
Locomotion velocity, NPP test0.60.92.4-1.3-1.1-0.6-1.0-0.50.7-0.9-0.7-0.51.5
Intraocular pressure1.82.55.01.51.52.21.40.7-2.21.92.20.8-0.0
Delta distance traveled before/after self-admin0.20.20.50.40.50.40.40.50.0-0.00.10.5-0.7
Delta ambulatory time before/after self-admin1.01.22.51.11.21.21.11.3-0.70.70.81.1-1.6
Parametrial fat weight0.20.41.2-1.0-0.7-0.3-0.20.60.4-1.1-0.5-0.1-0.1
Pavlov. Cond. lever latency0.40.51.0-0.7-0.7-1.0-0.7-0.50.8-0.9-0.8-0.70.1
Pavlov. Cond. magazine entry latency0.20.20.50.30.40.50.60.6-0.30.20.30.70.2
Pavlov. Cond. change in total contacts0.40.41.00.60.50.80.7-0.0-0.61.00.70.20.7
Pavlov. Cond. index score0.30.40.70.40.50.80.80.7-0.60.60.60.80.2
Pavlov. Cond. latency score0.40.50.80.50.50.90.90.7-0.70.70.70.80.4
Pavlov. Cond. lever contacts0.10.10.20.20.30.40.50.4-0.30.50.30.40.3
Pavlov. Cond. magazine entry number0.10.10.2-0.1-0.2-0.4-0.4-0.40.3-0.1-0.3-0.4-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.30.00.10.5-0.4-0.2-0.60.20.6-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.30.40.60.80.6-0.40.40.40.70.2
Pavlov. Cond. response bias0.30.40.60.60.60.80.80.6-0.60.60.60.70.1
Pavlov. Cond. lever latency0.20.30.80.60.60.5-0.2-0.5-0.50.70.4-0.2-0.9
Pavlov. Cond. magazine entry latency0.20.31.1-0.5-0.60.0-0.8-0.50.1-0.2-0.0-0.61.0
Pavlov. Cond. change in total contacts1.93.14.3-2.1-2.0-1.9-1.8-1.31.9-2.0-1.8-1.31.4
Pavlov. Cond. index score0.81.01.5-1.2-1.2-0.9-1.0-0.61.0-1.1-0.9-0.91.2
Pavlov. Cond. latency score0.40.61.0-0.9-0.9-0.6-0.8-0.40.7-0.8-0.6-0.61.0
Pavlov. Cond. lever contacts0.40.51.6-0.8-0.9-0.80.10.20.7-0.9-0.7-0.21.2
Pavlov. Cond. magazine entry number1.01.23.31.31.20.61.20.9-0.80.80.71.1-1.8
Pavlov. Cond. intertrial magazine entries0.10.20.80.00.1-0.10.30.70.1-0.2-0.10.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.91.21.9-1.3-1.3-0.9-1.2-0.81.0-1.1-0.9-1.11.4
Pavlov. Cond. response bias0.71.02.1-1.2-1.2-1.0-0.5-0.31.0-1.1-0.9-0.61.5
Time in closed arm before self-admin0.20.30.6-0.8-0.8-0.2-0.7-0.70.3-0.1-0.2-0.40.8
Time in closed arm after self-admin0.80.92.6-1.1-1.1-0.7-0.7-0.50.6-0.5-0.6-1.21.6
Time in open arm before self-admin0.10.10.20.20.3-0.00.10.5-0.20.00.30.2-0.1
Time in open arm after self-admin2.22.45.91.51.61.01.91.9-0.60.40.52.0-2.4
Bone: periosteal estimation0.71.42.1-1.5-1.4-1.1-1.2-1.40.9-0.9-0.9-1.41.1
Bone: periosteal perimeter1.32.22.9-1.7-1.6-1.6-1.6-1.51.5-1.3-1.5-1.60.8
Bone: post-yield work0.20.32.0-0.4-0.6-0.2-0.1-0.30.2-0.2-0.2-0.51.4
Progressive ratio test 1 active lever presses7.59.312.7-2.6-2.9-3.6-3.1-3.43.0-2.2-3.0-3.53.0
Progressive ratio test 1 breakpoint7.79.412.8-2.6-2.9-3.6-3.1-3.43.0-2.2-3.0-3.53.0
Progressive ratio test 1 inactive lever presses0.10.20.70.10.0-0.5-0.2-0.60.80.0-0.6-0.40.2
Progressive ratio test 2 active lever presses1.51.72.4-1.2-1.3-1.2-1.5-1.61.3-1.0-1.4-1.41.2
Progressive ratio test 2 breakpoint1.51.72.6-1.2-1.3-1.1-1.6-1.61.3-1.1-1.3-1.41.2
Progressive ratio test 2 inactive lever presses0.30.51.0-0.6-0.7-0.6-0.7-0.40.9-0.6-0.8-0.61.0
Incentive Sensitization - Responses0.30.50.9-0.7-0.7-0.2-0.9-0.80.5-0.8-0.6-0.60.5
Incentive Sensitization - Breakpoint0.20.30.6-0.6-0.6-0.0-0.8-0.70.4-0.7-0.4-0.40.3
Sum of active levers in priming session hrs 5-60.40.31.2-0.5-0.6-0.70.1-0.30.7-0.3-0.6-0.41.1
Progressive ratio0.91.43.01.21.31.10.11.2-1.10.91.21.3-1.7
Food seeking constrained by brief footshock1.31.63.6-0.9-1.0-1.3-1.7-1.90.9-0.9-0.9-1.41.0
Seeking ratio, punishment vs. effort1.31.93.5-1.4-1.5-1.3-0.9-1.51.2-1.2-1.3-1.51.9
Retroperitoneal fat weight2.410.416.3-4.0-3.7-3.1-3.4-2.83.0-3.4-3.0-3.02.7
Reaction time number correct0.10.20.5-0.2-0.30.50.10.1-0.60.40.5-0.20.7
Reaction time mean minus median0.51.43.21.01.11.11.11.1-1.10.71.01.8-1.3
Reaction time mean minus median AUC0.71.73.81.21.31.11.31.0-1.20.81.21.9-1.6
Reaction time num false alarms1.11.52.41.61.50.61.41.0-0.81.40.71.3-1.4
Reaction time num false alarms AUC1.32.03.21.81.70.71.71.4-0.91.60.81.6-1.6
Reaction time trials correct on left0.10.20.5-0.2-0.30.50.10.1-0.60.40.5-0.20.7
Reaction time trials on left0.10.20.5-0.2-0.20.60.20.1-0.70.50.6-0.10.6
Reaction time mean0.00.00.10.00.10.2-0.1-0.4-0.2-0.00.20.4-0.1
Reaction time mean AUC0.00.10.4-0.1-0.0-0.1-0.2-0.60.0-0.2-0.10.2-0.0
Median of all reaction times0.10.20.9-0.4-0.3-0.3-0.6-0.90.2-0.4-0.2-0.30.5
Reaction time omissions2.94.24.92.02.11.82.02.2-2.12.12.12.2-1.9
Reaction time false alarm rate1.21.73.11.81.70.51.51.2-0.61.30.51.4-1.7
Reaction time premature initiation rate0.20.31.4-0.7-0.6-0.50.50.10.3-0.3-0.2-0.21.2
Reaction time premature initiations0.30.52.6-0.9-0.9-0.40.3-0.10.1-0.2-0.1-0.51.6
Std. dev. reaction times0.91.63.41.21.31.11.21.2-1.11.01.11.9-1.4
Reaction time trials completed0.10.20.5-0.2-0.20.60.20.1-0.70.50.6-0.10.6
Reaction time trials AUC0.10.20.6-0.3-0.30.50.1-0.0-0.60.40.5-0.30.7
Run reversals in cocaine runway, females1.21.22.4-1.3-1.2-1.1-1.4-0.80.9-1.5-0.9-1.20.5
Run reversals in cocaine runway, males0.10.10.8-0.1-0.10.20.20.0-0.10.1-0.00.30.9
Latency to leave start box in cocaine runway0.10.10.5-0.7-0.60.0-0.3-0.30.1-0.2-0.20.30.4
Latency to leave start box in cocaine runway, F0.70.81.60.60.71.10.80.9-1.00.91.01.30.1
Latency to leave start box in cocaine runway, M2.32.13.3-1.8-1.8-1.3-1.5-1.41.5-1.6-1.6-1.00.4
Std. dev. time between licks in bursts0.60.83.60.00.2-0.80.10.90.8-0.8-0.81.2-1.9
Total sessions with >9 infusions2.42.94.7-1.5-1.6-2.0-1.7-2.21.4-1.3-1.3-2.11.6
Short access day 1 total inactive lever presses0.10.10.30.50.4-0.20.2-0.30.10.2-0.0-0.2-0.2
Short access day 10 total inactive lever presses1.53.76.71.92.02.21.52.6-1.10.91.22.6-2.5
Short access day 1 total infusions0.20.30.7-0.5-0.5-0.6-0.8-0.40.1-0.40.0-0.80.3
Short access day 10 total infusions2.93.75.6-1.7-1.8-2.4-1.8-2.02.1-1.7-2.1-2.01.4
Short access total infusions1.52.02.9-1.4-1.4-1.7-1.5-1.41.2-1.3-1.1-1.61.1
Short access day 1 locomotion0.91.21.9-0.9-1.1-1.4-0.8-1.11.0-1.1-0.9-1.31.0
Short access day 10 total locomotion0.51.03.31.81.60.20.90.2-0.11.2-0.10.6-1.3
Short access total locomotion0.70.81.9-0.2-0.4-1.4-0.5-1.41.0-0.5-1.1-1.10.3
One hour access (0.3 mA shock)5.66.49.4-2.5-2.6-2.2-3.1-2.92.4-1.9-2.5-2.82.3
Compulsive drug intake0.30.31.40.30.40.9-0.2-0.2-0.60.40.60.0-1.2
One hour access (shock baseline)3.35.06.4-2.1-2.2-2.4-2.3-2.12.5-1.9-2.5-2.22.2
Social response proportion3.23.65.7-2.3-2.3-1.7-1.7-1.01.9-2.4-1.9-1.71.9
Social responses2.02.65.5-2.3-2.1-1.4-1.6-0.51.3-2.0-1.3-1.11.5
Social time0.91.36.8-1.0-1.2-0.5-0.5-1.00.4-0.7-0.3-1.22.6
Soleus weight0.10.40.9-0.9-0.8-0.4-0.4-0.60.5-0.6-0.5-0.51.0
Bone: stiffness2.03.23.9-2.0-2.0-1.9-1.2-1.91.8-1.8-1.7-1.71.7
Tibialis anterior weight0.10.40.70.60.60.60.70.0-0.80.40.80.3-0.6
Time to tail flick, vehicle, before self-admin1.92.03.8-1.4-1.5-1.4-1.0-2.01.0-0.8-1.1-1.91.6
Time to tail flick, vehicle, after self-admin0.81.12.41.51.30.21.61.5-0.30.80.40.7-1.0
Time to tail flick, test, before self-admin0.10.10.2-0.4-0.3-0.5-0.5-0.3-0.10.00.2-0.20.2
Time to tail flick, test, after self-admin0.20.20.6-0.6-0.60.4-0.4-0.40.10.30.1-0.80.6
Delta time to tail flick, vehicle, before/after SA3.02.94.52.12.01.31.92.1-1.11.31.31.7-1.9
Delta time to tail flick, test, before/after SA0.10.10.80.10.10.90.40.3-0.00.20.10.1-0.1
Tibia length12.133.240.2-6.3-6.3-5.7-6.2-5.65.8-5.6-5.8-5.44.7
Ambulatory time before self-admin1.21.73.5-1.5-1.5-1.4-1.2-0.61.2-1.3-1.4-0.81.9
Ambulatory time after self-admin0.80.92.0-1.3-1.0-0.6-0.90.61.1-1.4-1.20.10.3
Bone: tissue strength0.40.40.6-0.6-0.7-0.8-0.4-0.80.7-0.4-0.7-0.60.7
Total heroin consumption0.30.31.10.00.30.50.61.0-0.30.30.30.9-0.6
Bone: trabecular number0.40.71.50.80.71.11.00.5-1.11.21.10.10.0
Bone: trabecular spacing0.10.21.10.10.30.1-0.20.5-0.1-0.10.10.6-1.0
Bone: trabecular thickness0.60.81.8-0.9-1.0-1.0-0.3-0.41.1-0.8-1.1-0.61.4
Bone: trabecular tissue density0.00.00.0-0.2-0.0-0.1-0.20.10.1-0.1-0.1-0.0-0.0
Water consumed over 24 hours1.82.44.7-1.2-1.4-2.1-0.8-2.21.4-1.0-1.4-1.61.6
Number of responses in last shaping day0.10.10.3-0.0-0.1-0.5-0.6-0.30.30.2-0.2-0.00.3