Hub : Genes

Fbxo47

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Fbxo47	0.04	0.04	7.8e-04	0.05	0.04	0.04	0.05	7.3e-05	7.1e-04	3.0e-04	9.0e-05
2	Brain	gene expression	Fbxo47	0.07	0.06	1.8e-06	0.04	0.06	0.05	0.05	8.6e-05	5.0e-06	1.5e-05	2.8e-05
3	Liver	gene expression	Fbxo47	0.05	0.04	8.7e-07	0.04	0.04	0.04	0.03	4.9e-05	2.6e-05	6.5e-05	1.2e-04
4	PL	gene expression	Fbxo47	0.03	0.02	3.5e-03	0.02	0.02	0.01	0.02	1.2e-03	3.6e-03	7.5e-03	1.8e-03
5	RMTg	mRNA stability	Fbxo47	0.11	0.1	8.5e-03	0.07	0.06	0.08	0.07	6.4e-03	8.7e-03	4.8e-03	7.4e-03
6	OFC	gene expression	Fbxo47	0.19	0.17	6.8e-03	0.06	0.01	0.05	0.04	1.9e-02	2.2e-01	3.1e-02	4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.7	3.0	3.9	2.0	1.8	1.8	1.7	-1.5	1.5
Area under the delay curve	0.9	1.1	1.4	0.7	1.1	1.1	1.0	-1.1	1.2
BMI with tail	1.8	6.2	7.4	-2.7	-2.6	-2.5	-2.4	2.4	-2.3
BMI without tail	1.6	4.8	5.5	-2.3	-2.3	-2.2	-2.2	2.0	-2.0
Body weight	7.4	32.3	33.9	-5.8	-5.8	-5.8	-5.4	5.7	-5.6
Weight adjusted by age	0.1	0.2	0.3	-0.6	-0.4	-0.4	-0.5	0.5	-0.5
Bone surface	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.0	0.3	-0.3
Bone volume	0.0	0.1	0.2	0.5	0.3	0.3	0.2	-0.0	0.0
Breakpoint value in progressive ratio session	1.8	2.2	2.5	-1.5	-1.6	-1.5	-1.3	1.6	-1.4
Number of licking bursts	0.5	0.8	0.9	0.9	0.8	0.8	1.0	-0.9	0.8
Context. condit. distance diff. score	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.8	0.6	-0.6
Locomotion velocity, session 1	1.3	1.4	1.9	-0.9	-1.1	-1.1	-1.4	1.2	-1.3
Locomotion distance, session 1	3.9	5.0	5.6	-2.4	-2.3	-2.3	-2.2	2.0	-2.1
Locomotion velocity, session 2	0.8	0.9	1.2	-0.8	-1.0	-1.0	-1.0	0.9	-1.1
Locomotion distance, session 2	1.0	1.4	1.6	-1.3	-1.2	-1.3	-1.2	1.0	-1.2
Locomotion velocity, session 3	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.3	0.4	-0.4
Locomotion distance, session 3	0.5	0.6	0.7	-0.8	-0.8	-0.8	-0.8	0.7	-0.8
Stereotopy head waving bouts, day 3	3.8	4.4	5.0	2.2	2.1	2.1	2.2	-2.0	2.0
Stereotopy head waving duration, day 3	0.7	0.8	1.0	1.0	0.9	0.9	1.0	-0.9	0.9
Locomotion velocity, session 7	0.6	0.7	1.0	-1.0	-0.9	-0.9	-0.9	0.6	-0.6
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.4	0.1	-0.0
Stereotopy head waving bouts, day 7	1.2	1.3	1.9	1.4	1.3	1.2	1.2	-0.8	0.9
Stereotopy head waving duration, day 7	0.2	0.3	0.6	0.8	0.6	0.6	0.6	-0.1	0.3
Locomotion velocity, session 8	6.7	8.1	8.7	-3.0	-2.9	-2.9	-2.8	2.7	-2.8
Locomotion distance, session 8	1.8	2.6	2.8	-1.7	-1.6	-1.6	-1.6	1.6	-1.6
Degree of sensitization distance	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.5	0.3	-0.2
Degree of sensitization stereotypy	1.6	1.8	2.4	1.5	1.4	1.4	1.3	-1.0	1.1
Conditioned locomotion	0.2	0.2	0.3	0.4	0.5	0.5	0.5	-0.5	0.5
Cocaine response after cond. corrected	2.0	2.4	3.5	1.9	1.6	1.6	1.4	-1.4	1.4
Cocaine response after cond. not corrected	3.1	3.6	5.0	2.2	2.0	2.0	1.8	-1.7	1.7
Cocaine response before conditioning	0.7	0.9	1.3	0.9	0.9	0.9	1.2	-0.9	0.9
Saline control response	0.0	0.1	0.1	0.1	0.2	0.2	0.4	-0.2	0.3
Bone: connectivity density	2.4	3.8	4.3	2.1	2.1	2.0	2.0	-1.8	1.8
Bone: cortical apparent density	4.2	5.7	7.6	2.8	2.6	2.6	2.3	-2.0	2.0
Bone: cortical area	0.2	0.3	0.5	0.6	0.5	0.5	0.7	-0.4	0.4
Bone: cortical porosity	1.2	1.3	2.0	1.0	1.0	1.0	1.0	-1.4	1.4
Bone: cortical porosity	1.2	1.3	2.0	0.9	1.0	1.0	0.9	-1.4	1.4
Bone: cortical thickness	1.3	2.2	3.1	1.7	1.6	1.6	1.5	-1.3	1.2
Bone: cortical thickness	4.8	5.7	6.1	2.4	2.4	2.4	2.5	-2.4	2.3
Bone: cortical tissue density	4.2	5.7	7.6	2.8	2.6	2.6	2.3	-2.0	2.0
Condit. Reinf. active minus inactive responses	0.4	0.5	0.5	0.7	0.7	0.7	0.7	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.1	0.8	0.9	0.9	0.9	-1.1	1.0
Condit. Reinf. active responses	0.6	0.7	1.0	1.0	0.9	0.9	0.8	-0.8	0.8
Condit. Reinf. inactive responses	0.4	0.5	0.9	0.9	0.8	0.8	0.6	-0.7	0.6
Incentive salience index mean	1.3	1.6	1.8	1.3	1.2	1.2	1.3	-1.3	1.3
Condit. Reinf. lever presses	1.3	1.8	2.0	1.3	1.3	1.3	1.3	-1.4	1.4
Condit. Reinf. active minus inactive responses	0.7	0.9	1.2	0.8	0.8	0.9	1.1	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	0.6	0.6	0.6	0.6	-0.6	0.7
Condit. Reinf. active responses	1.1	1.5	2.0	1.0	1.1	1.1	1.4	-1.4	1.3
Condit. Reinf. inactive responses	1.9	2.5	2.9	1.4	1.5	1.5	1.7	-1.7	1.6
Condit. Reinf. lever presses	0.1	0.1	0.2	0.1	0.1	0.1	0.4	-0.3	0.3
Condit. Reinf. lever reinforcers received	1.1	1.5	1.9	1.0	1.1	1.1	1.4	-1.3	1.3
Conditioned reinforcement - actives	0.8	1.4	2.1	1.0	0.9	1.0	1.1	-1.4	1.5
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.0	0.1	0.2	0.2	-0.7	0.7
Conditioned locomotion	1.6	2.0	2.5	1.3	1.4	1.4	1.3	-1.6	1.6
Patch foraging indifference point 0 sec	1.2	2.3	2.5	1.5	1.5	1.5	1.6	-1.5	1.5
Patch foraging indifference point AUC	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.3	0.6	-0.6
Delay disc. indifference point, 0s delay	1.9	2.1	2.5	1.6	1.5	1.5	1.2	-1.4	1.5
Delay disc. indifference point, 16s delay	0.5	0.6	0.7	0.7	0.8	0.8	0.8	-0.5	0.7
Delay disc. indifference point, 2s delay	2.6	2.9	3.2	1.7	1.7	1.7	1.5	-1.8	1.7
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.1	0.2	0.1	0.3	0.3	-0.2
Delay disc. indifference point, 4s delay	0.5	0.5	0.8	0.6	0.9	0.9	0.4	-0.7	0.6
Delay disc. indifference point, 8s delay	0.7	0.8	1.4	0.2	0.9	0.9	0.7	-1.1	1.2
Indifference point function ln k	0.0	0.1	0.2	-0.0	0.1	0.1	0.3	-0.4	0.5
Indifference point function log k	0.0	0.1	0.2	-0.0	0.1	0.1	0.3	-0.4	0.5
Patch foraging total patch changes 0 sec	0.7	1.3	1.5	1.1	1.1	1.1	1.2	-1.2	1.1
Patch foraging total patch changes 12 sec	3.8	4.9	5.8	2.4	2.3	2.3	2.2	-2.1	2.0
Patch foraging total patch changes 18 sec	0.1	0.2	0.7	0.8	0.5	0.5	0.5	-0.2	0.1
Patch foraging total patch changes 24 sec	1.0	1.7	2.9	1.7	1.5	1.4	1.2	-1.1	1.0
Patch foraging total patch changes 6 sec	0.8	1.2	1.7	1.3	1.2	1.2	1.1	-0.9	0.8
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.0	0.1	0.2	0.1	-0.3	0.4
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	0.0	0.0	0.2	0.1	-0.2
Patch foraging water rate 12 sec	0.2	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.5	-0.7
Patch foraging water rate 18 sec	0.5	0.8	1.3	0.6	0.9	0.9	0.8	-1.1	1.1
Patch foraging water rate 24 sec	0.3	0.4	0.5	0.3	0.6	0.6	0.7	-0.7	0.7
Patch foraging water rate 6 sec	0.8	1.2	1.4	1.1	1.1	1.1	1.2	-1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	0.0	-0.5	-0.5	-0.5	0.7	-0.7
Distance traveled before self-admin	0.1	0.1	0.2	-0.5	-0.5	-0.5	-0.5	0.1	-0.1
Distance traveled after self-admin	0.7	0.8	1.1	-0.9	-1.1	-1.0	-0.7	0.9	-0.8
Extensor digitorum longus weight	8.4	33.0	33.7	-5.8	-5.8	-5.8	-5.7	5.7	-5.7
Bone: elastic displacement	0.0	0.0	0.1	0.1	0.2	0.2	0.0	-0.3	0.3
Bone: elastic work	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	-0.0	0.0
Bone: endosteal estimation	1.7	3.8	4.5	-2.1	-2.1	-2.1	-1.8	1.8	-1.8
Bone: endosteal perimeter	1.8	3.7	4.5	-2.1	-2.1	-2.0	-1.8	1.8	-1.8
Epididymis fat weight	0.0	0.2	0.2	-0.3	-0.4	-0.4	-0.2	0.5	-0.4
Delta time in closed arm before/after self-admin	4.1	3.8	4.5	-2.1	-2.0	-2.0	-1.7	2.0	-1.9
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.0	0.1	0.1	-0.1	-0.2	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	-0.7	-0.4	-0.4	-0.2	0.2	-0.1
Delay discount exponential model param	0.6	0.6	0.8	-0.4	-0.9	-0.9	-0.7	0.9	-0.9
Extinction: sum of active levers before priming	0.5	0.6	0.9	-0.9	-0.7	-0.7	-0.5	0.9	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.1	0.0	0.1	0.1	0.2	0.3	-0.1
Bone: final force	1.2	2.0	2.3	1.5	1.4	1.4	1.5	-1.3	1.3
Bone: final moment	1.1	1.7	1.9	1.4	1.3	1.3	1.4	-1.3	1.3
Food consumed during 24 hour testing period	0.8	1.0	1.3	-0.9	-1.1	-1.1	-0.8	1.1	-1.1
Glucose	0.5	0.8	1.1	1.0	0.9	0.9	0.8	-0.8	0.8
Heart weight	3.4	5.3	6.9	-2.6	-2.3	-2.3	-2.3	2.2	-2.2
Delay discount hyperbolic model param	0.5	0.6	0.7	-0.4	-0.8	-0.9	-0.7	0.8	-0.9
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.3	-0.5	-0.5	-0.3	0.2	-0.2
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	-0.5	-0.4	-0.2	0.2	-0.1
Intermittent access intake escalation 2	0.6	0.7	0.9	-0.7	-0.9	-0.9	-0.7	0.9	-0.9
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.2	0.4	0.6	0.7	0.7	-1.1	1.0
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.0	1.0	1.0	1.0	0.7	-0.8	0.7
Intermitt. access escalation Index	1.0	1.4	1.9	-1.1	-1.1	-1.1	-1.0	1.3	-1.4
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0	-0.2	0.3
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.5	-0.4	-0.4	-0.2	0.0	0.0
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.1	-0.0	-0.0	0.2	-0.2	0.3
Intermittent access total infusions	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.1	0.0
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.1	0.4	0.4	0.4	-0.6	0.6
Intermittent access day 15 total locomotion	0.5	0.9	1.3	0.7	0.9	0.9	1.0	-1.1	1.1
Intermittent access total locomotion	1.3	1.6	2.2	1.0	1.2	1.2	1.2	-1.5	1.5
Intermittent access standard deviation	0.0	0.1	0.1	0.4	0.2	0.2	0.3	-0.2	0.3
Left kidney weight	1.2	5.8	6.6	-2.3	-2.4	-2.4	-2.3	2.6	-2.4
Right kidney weight	0.2	0.7	1.1	-0.6	-0.8	-0.8	-0.7	1.0	-0.9
Cocaine induced anxiety	3.5	5.0	5.7	-2.4	-2.3	-2.3	-2.1	2.2	-2.2
Post-drug Anxiety	0.9	1.0	1.5	-1.2	-1.1	-1.0	-0.9	0.9	-0.9
Baseline Anxiety	3.5	4.1	4.4	2.0	2.1	2.1	2.0	-2.0	2.0
Tail length	1.7	6.8	7.3	-2.5	-2.6	-2.6	-2.6	2.7	-2.6
Length with tail	4.9	21.3	22.5	-4.7	-4.6	-4.7	-4.4	4.7	-4.6
Length without tail	3.4	10.9	11.5	-3.4	-3.3	-3.3	-3.1	3.4	-3.3
Times rat made contact with spout	0.9	1.0	1.4	1.1	1.0	1.0	1.2	-0.9	0.9
Lifetime Intake	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.1	-0.0	0.1
Liver weight, left	0.2	0.3	0.5	-0.4	-0.5	-0.5	-0.6	0.7	-0.6
Liver weight, right	0.3	0.4	0.7	0.8	0.7	0.7	0.6	-0.5	0.7
Locomotor activity	0.5	0.8	0.9	0.9	1.0	0.9	1.0	-0.7	0.8
Locomotor testing distance	2.7	4.8	5.9	2.1	2.2	2.2	2.4	-2.0	2.2
Locomotor testing rearing	3.5	7.0	8.3	2.6	2.8	2.8	2.9	-2.4	2.5
Locomotion in novel chamber	2.8	3.6	4.8	2.0	2.2	2.1	1.8	-1.6	1.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	0.7	0.4	0.4	0.6	-0.4	0.5
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.6	-0.5	-0.5	-0.7	0.7	-0.6
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.6	0.7	0.7	0.8	-0.7	0.7
Time >=10cm from walls, locomotor time 1	0.9	1.0	1.5	0.9	0.9	0.9	0.7	-1.2	1.2
Bouts of movement, locomotor time 1	0.4	0.5	0.9	-0.8	-0.7	-0.7	-0.9	0.5	-0.4
Total resting periods, locomotor time 1	0.5	0.6	0.9	-0.9	-0.8	-0.8	-1.0	0.5	-0.5
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.3	-0.2	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.5	0.3	0.4	0.6	-0.2	0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.4	-0.6	-0.2	-0.2	-0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 2	1.4	2.0	2.7	1.2	1.4	1.5	1.1	-1.6	1.6
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.0	0.3	0.3	0.1	-0.3	0.5
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.3	0.0	0.1	-0.2	-0.2	0.4
Rest time, locomotor task time 2	1.0	1.3	2.0	-1.2	-1.2	-1.1	-1.4	0.9	-0.9
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	0.0	0.0	0.1	0.1	-0.1
Vertical activity count, locomotor time 2	0.0	0.1	0.3	-0.5	-0.2	-0.1	-0.0	-0.0	0.0
Light reinforcement 1	1.2	2.8	3.3	1.5	1.6	1.6	1.7	-1.8	1.8
Light reinforcement 2	0.5	0.8	1.0	0.9	0.9	0.9	1.0	-0.9	0.9
Bone: marrow area	1.6	3.6	4.3	-2.1	-2.0	-2.0	-1.8	1.7	-1.7
Bone: maximum diameter	0.0	0.0	0.1	0.1	-0.0	-0.0	0.2	0.0	-0.0
Bone: maximum force	0.0	0.0	0.1	0.3	0.1	0.1	0.3	-0.2	0.1
Bone: maximum moment	0.0	0.0	0.0	0.2	0.0	0.0	0.2	-0.2	0.1
Mean time between licks in bursts	1.0	2.5	3.1	-1.7	-1.6	-1.6	-1.7	1.4	-1.4
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0	-0.0
Cd content in liver	1.0	1.1	1.5	-1.2	-1.2	-1.2	-0.9	0.9	-0.9
Co content in liver	2.4	2.8	3.0	-1.6	-1.6	-1.6	-1.6	1.7	-1.7
Cu content in liver	0.8	1.0	1.3	-0.8	-1.0	-1.0	-1.1	1.1	-1.1
Fe content in liver	2.3	2.7	2.9	-1.6	-1.6	-1.6	-1.6	1.7	-1.7
K content in liver	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.1	0.0
Mg content in liver	0.1	0.1	0.2	0.4	0.3	0.3	0.0	-0.1	0.1
Mn content in liver	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.2	0.2
Na content in liver	0.1	0.1	0.2	0.5	0.4	0.4	0.3	-0.3	0.3
Rb content in liver	1.4	1.6	1.8	1.2	1.3	1.3	1.2	-1.3	1.3
Se content in liver	3.1	3.6	4.4	2.1	2.0	2.0	1.8	-1.8	1.8
Sr content in liver	1.2	1.0	1.0	-1.0	-1.0	-1.0	-1.0	1.0	-1.0
Zn content in liver	1.5	1.7	1.8	1.3	1.3	1.3	1.2	-1.3	1.3
Bone: minimum diameter	0.5	0.9	1.0	-1.0	-1.0	-1.0	-0.6	1.0	-1.0
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.5	0.7	0.7	0.9	-0.7	0.8
Time in novel zone, hab. session 1	0.7	0.7	0.9	1.0	0.8	0.8	0.6	-0.8	0.8
Total zone transitions, hab. session 1	2.2	3.0	3.3	-1.8	-1.8	-1.8	-1.8	1.6	-1.6
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.0	-0.1	-0.0
Locomotion velocity, hab. session 1	0.5	0.7	0.9	-1.0	-0.9	-0.9	-0.7	0.6	-0.7
Time in familiar zone, hab. session 2	0.7	0.7	0.9	0.7	0.8	0.8	0.8	-1.0	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	0.2	0.1	0.1	-0.1	0.1
Total zone transitions, hab. session 2	0.5	0.7	1.0	-1.0	-0.9	-0.9	-0.8	0.6	-0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.5	-0.4	-0.3	-0.1	0.1	-0.1
Locomotion velocity, hab. session 2	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.3	0.3	-0.4
Novel to familiar place preference ratio	1.6	1.7	2.2	-1.3	-1.3	-1.3	-1.3	1.5	-1.4
Novelty place preference	1.0	1.0	1.3	-1.0	-1.0	-1.0	-1.0	1.1	-1.0
Time in novel zone, NPP test	0.2	0.3	0.4	-0.5	-0.5	-0.5	-0.5	0.6	-0.5
Total zone transitions, NPP test	0.2	0.4	0.5	-0.7	-0.7	-0.7	-0.5	0.4	-0.5
Total locomotion distance, NPP test	0.0	0.0	0.1	0.0	0.0	0.0	0.1	-0.3	0.2
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.6	-0.7	-0.7	-0.5	0.4	-0.5
Intraocular pressure	1.5	2.2	2.7	-1.6	-1.4	-1.4	-1.2	1.6	-1.5
Delta distance traveled before/after self-admin	0.6	0.6	0.7	-0.8	-0.8	-0.8	-0.5	0.9	-0.8
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.1	0.6	-0.5
Parametrial fat weight	0.5	1.2	1.6	0.9	1.0	1.0	1.2	-1.2	1.3
Pavlov. Cond. lever latency	2.7	3.4	4.0	-1.8	-1.8	-1.8	-2.0	1.8	-1.7
Pavlov. Cond. magazine entry latency	9.4	12.1	13.4	3.6	3.6	3.6	3.7	-3.3	3.2
Pavlov. Cond. change in total contacts	8.4	8.9	10.2	3.2	3.1	3.1	3.1	-2.6	2.6
Pavlov. Cond. index score	9.1	11.5	12.9	3.4	3.5	3.5	3.6	-3.2	3.2
Pavlov. Cond. latency score	7.1	9.0	10.2	3.0	3.1	3.1	3.2	-2.8	2.8
Pavlov. Cond. lever contacts	3.4	4.1	4.6	2.0	2.0	2.0	2.1	-2.0	1.9
Pavlov. Cond. magazine entry number	13.7	17.3	18.6	-4.3	-4.3	-4.3	-4.3	3.9	-3.9
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.0	-1.3	-1.3	-1.3	-1.4	1.2	-1.2
Pavlov. Cond. lever-magazine prob. diff.	10.7	13.2	14.7	3.7	3.7	3.7	3.8	-3.4	3.4
Pavlov. Cond. response bias	10.5	13.0	14.2	3.7	3.7	3.7	3.8	-3.4	3.4
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.8	0.5	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.1	0.1	-0.2
Pavlov. Cond. change in total contacts	0.4	0.6	0.8	0.7	0.7	0.8	0.8	-0.9	0.8
Pavlov. Cond. index score	0.1	0.2	0.3	0.4	0.4	0.4	0.6	-0.4	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	0.4	0.4	0.4	0.6	-0.3	0.2
Pavlov. Cond. lever contacts	0.5	0.7	1.0	0.8	0.8	0.8	1.0	-0.8	0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.4	-0.4	-0.4	-0.5	0.5	-0.4
Pavlov. Cond. intertrial magazine entries	1.5	2.2	2.3	-1.5	-1.5	-1.5	-1.5	1.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.3	0.3	0.3	0.4	-0.3	0.2
Pavlov. Cond. response bias	0.7	1.0	1.2	1.0	1.0	1.0	1.1	-1.0	0.9
Time in closed arm before self-admin	1.8	2.3	2.9	1.7	1.4	1.4	1.6	-1.5	1.4
Time in closed arm after self-admin	0.4	0.4	0.5	-0.7	-0.6	-0.6	-0.3	0.7	-0.6
Time in open arm before self-admin	3.0	3.2	3.5	-1.8	-1.7	-1.7	-1.9	1.9	-1.8
Time in open arm after self-admin	0.5	0.5	0.8	-0.6	-0.7	-0.7	-0.9	0.6	-0.8
Bone: periosteal estimation	0.1	0.3	0.4	-0.6	-0.6	-0.6	-0.4	0.5	-0.5
Bone: periosteal perimeter	0.6	1.1	1.3	-1.1	-1.1	-1.1	-0.8	1.0	-1.0
Bone: post-yield work	0.6	0.9	1.2	-1.1	-1.0	-1.0	-0.9	0.8	-0.8
Progressive ratio test 1 active lever presses	0.4	0.5	0.7	0.7	0.7	0.7	0.8	-0.7	0.8
Progressive ratio test 1 breakpoint	0.4	0.5	0.7	0.7	0.6	0.6	0.8	-0.7	0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	-0.1	0.1	0.1	0.3	-0.6	0.6
Progressive ratio test 2 active lever presses	0.5	0.6	0.8	0.8	0.7	0.7	0.7	-0.8	0.9
Progressive ratio test 2 breakpoint	0.6	0.7	0.9	0.9	0.8	0.8	0.7	-0.9	1.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.3	-0.4	-0.3	-0.6	0.3	-0.2
Incentive Sensitization - Responses	0.5	0.7	0.9	1.0	0.8	0.8	0.7	-0.9	1.0
Incentive Sensitization - Breakpoint	0.4	0.5	0.7	0.9	0.7	0.7	0.5	-0.7	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.3	0.4	0.4	0.4	-0.2	0.4
Progressive ratio	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.0	0.0	-0.3
Food seeking constrained by brief footshock	0.5	0.6	0.9	0.8	0.7	0.7	0.7	-0.9	0.8
Seeking ratio, punishment vs. effort	0.2	0.3	0.5	0.5	0.5	0.6	0.4	-0.5	0.7
Retroperitoneal fat weight	0.2	0.7	1.1	0.7	0.6	0.7	0.9	-0.9	1.0
Reaction time number correct	0.5	1.0	1.4	-1.2	-1.1	-1.1	-1.0	0.8	-0.9
Reaction time mean minus median	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.1	0.2	-0.2
Reaction time mean minus median AUC	0.2	0.4	0.5	0.6	0.6	0.6	0.7	-0.7	0.7
Reaction time num false alarms	0.7	1.0	1.2	1.0	0.9	0.9	1.0	-1.0	1.1
Reaction time num false alarms AUC	0.5	0.7	0.9	0.9	0.8	0.8	0.8	-0.8	1.0
Reaction time trials correct on left	0.5	1.0	1.4	-1.2	-1.1	-1.1	-1.0	0.8	-0.9
Reaction time trials on left	0.5	0.9	1.3	-1.2	-1.0	-1.0	-0.9	0.8	-0.8
Reaction time mean	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	0.1	-0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.0	0.0	0.0	-0.2	0.2	-0.2
Median of all reaction times	0.1	0.1	0.3	0.5	0.5	0.5	0.3	-0.2	0.2
Reaction time omissions	0.3	0.5	0.5	0.7	0.6	0.6	0.7	-0.7	0.7
Reaction time false alarm rate	1.3	1.8	2.2	1.5	1.3	1.3	1.3	-1.3	1.4
Reaction time premature initiation rate	0.3	0.5	0.7	0.7	0.6	0.6	0.8	-0.7	0.7
Reaction time premature initiations	0.0	0.0	0.1	-0.3	-0.3	-0.3	-0.0	0.1	-0.1
Std. dev. reaction times	0.0	0.0	0.0	0.1	0.1	0.1	0.2	-0.0	0.1
Reaction time trials completed	0.5	0.9	1.3	-1.2	-1.0	-1.0	-0.9	0.8	-0.8
Reaction time trials AUC	0.4	0.8	1.1	-1.1	-0.9	-0.9	-0.9	0.7	-0.8
Run reversals in cocaine runway, females	1.3	1.3	1.6	-1.3	-1.2	-1.2	-1.1	0.9	-1.0
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.2	0.5	0.5	0.5	-0.7	0.7
Latency to leave start box in cocaine runway	2.7	3.1	3.9	-1.6	-1.8	-1.8	-2.0	1.8	-1.6
Latency to leave start box in cocaine runway, F	3.2	3.6	4.2	-1.7	-2.0	-2.0	-2.0	1.9	-1.8
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	-0.5	-0.5	-0.5	-0.8	0.7	-0.5
Std. dev. time between licks in bursts	0.3	0.4	0.5	-0.6	-0.6	-0.6	-0.7	0.7	-0.7
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	0.0	0.1	0.2	-0.2	0.3
Short access day 1 total inactive lever presses	0.9	1.1	1.6	0.8	1.0	1.0	1.0	-1.2	1.3
Short access day 10 total inactive lever presses	0.2	0.6	0.8	-0.8	-0.9	-0.9	-0.8	0.6	-0.6
Short access day 1 total infusions	0.0	0.0	0.0	0.1	0.2	0.1	0.0	-0.0	0.0
Short access day 10 total infusions	0.1	0.2	0.2	0.3	0.5	0.5	0.4	-0.4	0.5
Short access total infusions	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	0.1	-0.0
Short access day 1 locomotion	0.6	0.7	0.7	0.8	0.8	0.8	0.9	-0.8	0.8
Short access day 10 total locomotion	2.0	3.7	4.4	1.7	1.9	1.9	2.1	-1.9	1.9
Short access total locomotion	0.3	0.3	0.4	0.3	0.5	0.5	0.6	-0.7	0.6
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.1	0.3
Compulsive drug intake	0.2	0.2	0.4	0.6	0.4	0.4	0.4	-0.4	0.4
One hour access (shock baseline)	0.1	0.1	0.3	-0.5	-0.4	-0.4	-0.2	0.2	-0.1
Social response proportion	0.1	0.1	0.2	0.0	0.1	0.1	-0.2	-0.5	0.3
Social responses	0.1	0.1	0.4	0.2	0.3	0.3	0.1	-0.6	0.5
Social time	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	0.1	-0.1
Soleus weight	0.5	1.4	1.7	1.3	1.2	1.2	1.2	-1.0	1.0
Bone: stiffness	0.0	0.0	0.1	0.3	0.1	0.1	0.3	-0.1	0.1
Tibialis anterior weight	1.4	4.7	5.1	-2.1	-2.1	-2.1	-2.1	2.3	-2.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	0.4	0.6	0.6	0.6	-0.4	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.2	0.2	0.2	0.6	0.0	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.5	0.5	-0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	0.3	0.3	0.2	-0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	0.6	0.6	0.6	0.7	-0.6	0.5
Delta time to tail flick, test, before/after SA	1.8	1.8	2.1	1.3	1.4	1.4	1.3	-1.2	1.3
Tibia length	0.7	2.0	2.5	-1.3	-1.4	-1.4	-1.2	1.6	-1.6
Ambulatory time before self-admin	0.4	0.6	1.0	-0.8	-0.8	-0.8	-1.0	0.4	-0.5
Ambulatory time after self-admin	2.1	2.4	2.8	-1.5	-1.7	-1.7	-1.4	1.6	-1.5
Bone: tissue strength	0.5	0.5	0.7	-0.5	-0.6	-0.7	-0.7	0.8	-0.8
Total heroin consumption	0.3	0.3	0.5	0.6	0.7	0.7	0.5	-0.2	0.5
Bone: trabecular number	5.0	8.3	9.2	3.0	3.0	3.0	2.9	-2.7	2.7
Bone: trabecular spacing	0.9	1.2	1.5	-1.2	-1.1	-1.1	-1.1	0.9	-0.9
Bone: trabecular thickness	0.0	0.0	0.1	0.2	0.1	0.1	0.0	0.1	-0.1
Bone: trabecular tissue density	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.2	0.1	-0.1
Water consumed over 24 hours	0.0	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.0
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.3	-0.3	-0.3	0.5	-0.5