Hub : Genes

Fbxo27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XM_063270886.1	0.03	0.02	3.0e-03	0	0.01	0	0	1.3e-01	2.8e-02	3.1e-01	1.2e-01
2	Liver	alternative TSS	XM_063270889.1	0.03	0.02	3.5e-03	0	0.01	0	0	1.3e-01	2.2e-02	3.0e-01	1.4e-01
3	Liver	alternative TSS	XM_063270886.1	0.03	0.02	5.8e-04	0.01	0.02	0.01	0.02	3.5e-02	1.7e-03	1.2e-02	5.6e-03
4	Liver	alternative TSS	XM_039087244.2	0.03	0.03	4.4e-04	0.01	0.02	0.02	0.02	3.5e-02	1.8e-03	3.8e-03	6.1e-03
5	Liver	isoform ratio	XM_063270889.1	0.02	0.02	7.4e-03	0.01	0.01	0	0	1.2e-02	7.0e-02	1.2e-01	9.2e-02
6	Liver	gene expression	Fbxo27	0.19	0.13	1.5e-14	0.12	0.12	0.11	0.12	3.5e-13	5.2e-13	3.3e-12	3.8e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	0.7	-0.3	-0.3	-0.6	0.6	-0.8	0.8
Area under the delay curve	0.2	0.2	0.4	0.3	0.3	0.5	-0.5	0.6	-0.6
BMI with tail	0.4	1.4	1.8	0.9	1.0	1.2	-1.2	1.3	-1.3
BMI without tail	0.3	0.9	1.5	-1.2	-1.2	-1.0	1.0	-0.4	0.4
Body weight	1.8	7.8	11.3	-3.4	-3.3	-3.0	3.0	-1.8	1.8
Weight adjusted by age	0.2	0.2	0.4	0.3	0.3	0.4	-0.5	0.7	-0.7
Bone surface	1.1	2.1	2.2	-1.3	-1.3	-1.5	1.5	-1.5	1.5
Bone volume	1.1	1.9	2.1	-1.3	-1.3	-1.5	1.5	-1.4	1.4
Breakpoint value in progressive ratio session	1.1	1.4	3.5	-0.1	0.0	0.8	-0.8	1.9	-1.9
Number of licking bursts	0.3	0.5	1.2	0.6	0.6	-0.0	0.1	-1.1	1.1
Context. condit. distance diff. score	0.1	0.1	0.1	0.4	0.4	0.3	-0.3	0.3	-0.3
Locomotion velocity, session 1	2.5	2.7	3.4	1.9	1.9	1.8	-1.7	1.3	-1.3
Locomotion distance, session 1	0.5	0.6	0.9	-0.9	-0.9	-0.8	0.8	-0.5	0.5
Locomotion velocity, session 2	0.2	0.3	0.4	0.7	0.6	0.6	-0.6	0.3	-0.3
Locomotion distance, session 2	1.5	2.0	2.2	1.3	1.3	1.5	-1.5	1.5	-1.5
Locomotion velocity, session 3	2.3	2.6	4.9	-0.8	-0.9	-1.4	1.5	-2.2	2.2
Locomotion distance, session 3	5.6	6.1	8.3	-2.9	-2.9	-2.6	2.6	-1.8	1.8
Stereotopy head waving bouts, day 3	0.8	1.0	1.1	0.9	0.9	1.0	-1.0	1.0	-1.0
Stereotopy head waving duration, day 3	2.0	2.4	3.3	1.8	1.8	1.6	-1.6	1.1	-1.1
Locomotion velocity, session 7	0.8	0.9	1.4	-0.6	-0.6	-0.9	0.9	-1.2	1.2
Locomotion distance, session 7	0.8	1.0	1.2	-0.8	-0.8	-1.0	1.0	-1.1	1.1
Stereotopy head waving bouts, day 7	1.2	1.4	1.7	1.0	1.0	1.2	-1.2	1.3	-1.3
Stereotopy head waving duration, day 7	1.7	2.1	2.3	1.4	1.4	1.5	-1.5	1.4	-1.4
Locomotion velocity, session 8	0.8	0.9	2.0	1.4	1.4	0.9	-0.9	-0.0	0.0
Locomotion distance, session 8	1.4	2.0	2.2	1.3	1.3	1.5	-1.5	1.5	-1.5
Degree of sensitization distance	1.7	1.7	3.0	1.7	1.7	1.4	-1.3	0.6	-0.6
Degree of sensitization stereotypy	0.6	0.6	1.1	0.5	0.5	0.7	-0.8	1.0	-1.0
Conditioned locomotion	2.4	2.8	3.1	-1.6	-1.6	-1.8	1.8	-1.7	1.7
Cocaine response after cond. corrected	1.0	1.3	1.4	-1.1	-1.1	-1.2	1.2	-1.1	1.1
Cocaine response after cond. not corrected	1.3	1.6	1.8	-1.3	-1.3	-1.3	1.3	-1.1	1.1
Cocaine response before conditioning	0.4	0.5	1.1	-1.0	-1.0	-0.7	0.7	0.0	-0.0
Saline control response	1.0	1.3	2.5	0.5	0.6	1.0	-1.0	1.6	-1.6
Bone: connectivity density	0.1	0.1	0.2	0.3	0.3	0.0	0.0	-0.5	0.5
Bone: cortical apparent density	3.4	4.6	5.2	2.3	2.3	2.3	-2.3	1.8	-1.8
Bone: cortical area	0.7	1.1	2.4	-1.5	-1.5	-1.0	1.0	0.0	-0.0
Bone: cortical porosity	0.4	0.4	0.4	0.6	0.6	0.7	-0.7	0.6	-0.6
Bone: cortical porosity	0.3	0.3	0.4	0.6	0.6	0.6	-0.6	0.4	-0.4
Bone: cortical thickness	0.4	0.7	1.5	-1.2	-1.2	-0.8	0.7	0.1	-0.1
Bone: cortical thickness	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.4	-0.4	0.4
Bone: cortical tissue density	3.4	4.7	5.5	2.3	2.3	2.3	-2.3	1.8	-1.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	0.1	-0.1	0.1	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.3	0.2	-0.2	0.1	-0.1
Condit. Reinf. active responses	0.2	0.2	0.5	0.7	0.6	0.3	-0.3	-0.3	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.7	0.7	0.5	-0.5	0.0	-0.0
Incentive salience index mean	0.7	0.9	1.5	-0.5	-0.6	-0.9	0.9	-1.2	1.2
Condit. Reinf. lever presses	1.0	1.4	1.8	-0.9	-1.0	-1.2	1.2	-1.3	1.3
Condit. Reinf. active minus inactive responses	1.2	1.6	3.3	-1.8	-1.8	-1.3	1.2	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.0	-1.0	-0.9	-0.3	0.3	0.8	-0.8
Condit. Reinf. active responses	1.7	2.4	4.6	-2.1	-2.1	-1.6	1.6	-0.4	0.4
Condit. Reinf. inactive responses	0.4	0.5	1.0	-1.0	-1.0	-0.7	0.7	-0.2	0.2
Condit. Reinf. lever presses	4.4	6.0	9.2	-3.0	-3.0	-2.6	2.6	-1.5	1.5
Condit. Reinf. lever reinforcers received	2.9	4.1	6.9	-2.6	-2.6	-2.2	2.1	-1.0	1.0
Conditioned reinforcement - actives	0.5	0.8	1.6	-0.4	-0.4	-0.8	0.8	-1.3	1.3
Conditioned reinforcement - inactives	3.1	4.6	5.4	-1.9	-1.9	-2.2	2.2	-2.3	2.3
Conditioned locomotion	0.3	0.4	1.0	1.0	1.0	0.6	-0.6	-0.2	0.2
Patch foraging indifference point 0 sec	0.3	0.5	0.6	-0.8	-0.8	-0.8	0.8	-0.6	0.6
Patch foraging indifference point AUC	2.3	3.3	3.7	1.6	1.6	1.9	-1.9	1.9	-1.9
Delay disc. indifference point, 0s delay	1.1	1.2	2.4	0.5	0.5	1.0	-1.0	1.6	-1.6
Delay disc. indifference point, 16s delay	0.9	1.0	1.3	-1.1	-1.1	-1.1	1.1	-0.8	0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.2	0.4	0.4	0.5	-0.5	0.4	-0.4
Delay disc. indifference point, 24s delay	1.6	1.8	2.1	-1.4	-1.4	-1.4	1.4	-1.2	1.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.0	0.1	0.2	-0.2	0.3	-0.3
Delay disc. indifference point, 8s delay	2.1	2.4	2.7	1.5	1.6	1.6	-1.6	1.5	-1.5
Indifference point function ln k	1.9	3.3	4.0	-1.5	-1.6	-1.9	1.9	-2.0	2.0
Indifference point function log k	1.9	3.3	4.0	-1.5	-1.6	-1.9	1.9	-2.0	2.0
Patch foraging total patch changes 0 sec	0.4	0.7	0.8	-0.9	-0.9	-0.9	0.9	-0.7	0.7
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	-0.2	-0.1	0.1	-0.1	0.4	-0.4
Patch foraging total patch changes 18 sec	2.6	4.0	5.1	1.6	1.7	2.1	-2.1	2.3	-2.3
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	-0.6	-0.6	-0.4	0.4	-0.1	0.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	0.2	0.2	0.5	-0.5	0.8	-0.8
Patch foraging time to switch 0 sec	0.6	1.2	1.7	1.3	1.3	1.2	-1.1	0.7	-0.7
Patch foraging water rate 0 sec	0.6	1.3	2.9	-0.3	-0.4	-0.9	0.9	-1.7	1.7
Patch foraging water rate 12 sec	2.2	4.6	5.1	-1.9	-2.0	-2.2	2.2	-2.2	2.2
Patch foraging water rate 18 sec	0.6	0.9	2.3	-0.1	-0.2	-0.7	0.8	-1.5	1.5
Patch foraging water rate 24 sec	1.6	2.3	2.5	-1.4	-1.4	-1.6	1.6	-1.5	1.5
Patch foraging water rate 6 sec	1.9	2.8	4.3	-1.2	-1.2	-1.7	1.7	-2.1	2.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	-0.8	-0.8	-0.5	0.4	0.2	-0.2
Distance traveled before self-admin	1.2	1.6	2.7	-1.7	-1.6	-1.4	1.4	-0.6	0.6
Distance traveled after self-admin	1.3	1.6	2.7	-1.7	-1.6	-1.3	1.3	-0.5	0.5
Extensor digitorum longus weight	0.1	0.3	0.6	0.8	0.7	0.6	-0.5	0.1	-0.1
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.2	0.2
Bone: elastic work	2.5	3.2	4.3	-2.1	-2.1	-1.9	1.9	-1.3	1.3
Bone: endosteal estimation	0.1	0.3	0.7	-0.8	-0.8	-0.4	0.3	0.4	-0.4
Bone: endosteal perimeter	0.3	0.6	1.1	-1.1	-1.0	-0.8	0.8	-0.2	0.2
Epididymis fat weight	0.1	0.2	0.3	-0.3	-0.3	-0.4	0.4	-0.5	0.5
Delta time in closed arm before/after self-admin	1.0	1.0	1.6	-0.6	-0.6	-1.0	1.0	-1.3	1.3
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1	0.3	-0.3
Diff in mean of infusions in LGA sessions	0.8	1.0	1.7	0.6	0.6	1.0	-1.0	1.3	-1.3
Delay discount exponential model param	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.3	-0.5	0.5
Extinction: sum of active levers before priming	0.4	0.5	1.0	-1.0	-0.9	-0.5	0.4	0.5	-0.5
Active lever presses in extinction session 6	0.5	0.5	1.0	0.2	0.3	0.6	-0.6	1.0	-1.0
Bone: final force	0.8	1.3	2.3	-1.5	-1.5	-1.2	1.2	-0.5	0.5
Bone: final moment	1.5	2.4	3.9	-2.0	-2.0	-1.7	1.6	-0.8	0.8
Food consumed during 24 hour testing period	1.4	1.9	2.4	-1.2	-1.2	-1.4	1.4	-1.5	1.5
Glucose	1.3	2.0	4.1	-0.6	-0.7	-1.2	1.3	-2.0	2.0
Heart weight	0.9	1.4	2.0	-1.4	-1.4	-1.3	1.2	-0.8	0.8
Delay discount hyperbolic model param	0.2	0.2	0.2	-0.3	-0.3	-0.4	0.4	-0.5	0.5
Intermittent access intake day 1-15 change	0.1	0.2	0.3	-0.6	-0.5	-0.5	0.5	-0.2	0.2
Intermittent access intake escalation	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2	-0.0	0.0
Intermittent access intake escalation 2	0.5	0.5	1.3	-0.5	-0.5	0.1	-0.2	1.1	-1.1
Intermitt. access day 1 inactive lever presses	1.4	5.3	6.2	-2.5	-2.5	-2.5	2.4	-1.9	1.9
Intermitt. access day 15 inactive lever presses	1.7	3.4	3.8	-1.6	-1.7	-1.9	1.9	-1.9	1.9
Intermitt. access escalation Index	0.5	0.7	1.6	0.1	0.2	0.6	-0.6	1.3	-1.3
Intermittent access day 1 total infusions	1.0	1.7	2.9	-0.7	-0.8	-1.2	1.2	-1.7	1.7
Intermittent access day 15 total infusions	0.9	1.4	1.6	-1.0	-1.0	-1.2	1.2	-1.3	1.3
Intermittent access terminal intake (last 3 days)	1.2	1.6	1.8	-1.3	-1.3	-1.3	1.3	-1.1	1.1
Intermittent access total infusions	1.7	2.1	2.9	-1.1	-1.1	-1.4	1.5	-1.7	1.7
Intermittent access day 1 locomotion	1.0	1.3	1.8	-0.9	-0.9	-1.2	1.2	-1.3	1.3
Intermittent access day 15 total locomotion	0.5	0.9	1.5	-0.5	-0.6	-0.9	0.9	-1.2	1.2
Intermittent access total locomotion	0.8	0.9	1.8	-0.4	-0.4	-0.8	0.9	-1.4	1.4
Intermittent access standard deviation	0.3	0.6	0.9	-0.9	-0.8	-0.2	0.1	1.0	-1.0
Left kidney weight	1.5	6.9	12.4	-3.5	-3.5	-2.8	2.7	-1.0	1.0
Right kidney weight	1.8	8.0	13.4	-3.7	-3.6	-3.0	3.0	-1.4	1.4
Cocaine induced anxiety	1.1	1.6	1.8	1.2	1.2	1.3	-1.3	1.3	-1.3
Post-drug Anxiety	0.7	0.7	1.1	0.6	0.6	0.8	-0.9	1.1	-1.1
Baseline Anxiety	2.1	2.4	2.8	-1.7	-1.7	-1.6	1.6	-1.3	1.3
Tail length	3.8	14.9	21.2	-4.6	-4.6	-4.1	4.1	-2.6	2.6
Length with tail	6.0	26.1	34.8	-5.9	-5.9	-5.5	5.4	-3.7	3.7
Length without tail	1.3	4.3	5.9	-2.4	-2.4	-2.2	2.2	-1.4	1.4
Times rat made contact with spout	1.2	1.4	1.5	1.1	1.1	1.2	-1.2	1.2	-1.2
Lifetime Intake	1.2	1.5	2.3	-0.8	-0.8	-1.2	1.2	-1.5	1.5
Liver weight, left	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.5	-0.3	0.3
Liver weight, right	0.3	0.4	0.5	-0.5	-0.6	-0.7	0.7	-0.7	0.7
Locomotor activity	0.9	1.3	1.5	1.2	1.2	1.2	-1.2	1.1	-1.1
Locomotor testing distance	1.3	2.4	2.8	1.7	1.7	1.7	-1.7	1.3	-1.3
Locomotor testing rearing	4.1	8.3	9.5	2.5	2.6	3.0	-3.0	3.1	-3.1
Locomotion in novel chamber	1.5	1.9	2.2	1.3	1.4	1.5	-1.5	1.4	-1.4
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.3	-0.4	0.4
Fecal boli incidents, locomotor time 1	0.5	0.7	1.2	1.1	1.0	0.3	-0.3	-0.9	0.9
Change in fecal boli incidents, locomotor task	3.1	3.1	5.2	1.1	1.1	1.7	-1.7	2.3	-2.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	-0.2	0.2
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.1	0.1	0.3	-0.4	0.7	-0.7
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.1	0.3	-0.3
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.1	-0.2	-0.4	0.4	-0.7	0.7
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.1	-0.0	0.2	-0.2	0.5	-0.5
Vertical activity count, locomotor time 1	0.1	0.3	0.4	-0.6	-0.6	-0.2	0.1	0.6	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.0	0.0	0.2	-0.2	0.3	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	1.0	0.0	-0.0	-0.4	0.4	-1.0	1.0
Total resting periods, locomotor time 2	0.2	0.3	0.8	0.1	0.1	-0.3	0.3	-0.9	0.9
Rest time, locomotor task time 2	0.5	0.6	0.7	-0.8	-0.9	-0.9	0.9	-0.7	0.7
Distance moved, locomotor task time 2	1.0	1.2	1.7	0.8	0.8	1.1	-1.1	1.3	-1.3
Vertical activity count, locomotor time 2	0.9	1.2	2.3	0.5	0.6	1.0	-1.0	1.5	-1.5
Light reinforcement 1	0.1	0.2	0.3	0.6	0.6	0.5	-0.5	0.2	-0.2
Light reinforcement 2	1.3	2.0	4.6	2.1	2.0	1.2	-1.2	-0.5	0.5
Bone: marrow area	0.2	0.3	0.7	-0.8	-0.8	-0.4	0.3	0.5	-0.5
Bone: maximum diameter	1.3	2.4	3.3	-1.8	-1.8	-1.7	1.6	-1.1	1.1
Bone: maximum force	0.9	1.6	3.4	-1.8	-1.8	-1.2	1.2	-0.0	0.0
Bone: maximum moment	1.4	2.4	4.9	-2.2	-2.2	-1.6	1.5	-0.3	0.3
Mean time between licks in bursts	0.2	0.4	0.4	-0.7	-0.7	-0.7	0.7	-0.6	0.6
Mean num. licks in bursts	0.8	1.3	3.1	0.1	0.2	0.8	-0.9	1.7	-1.7
Cd content in liver	3.5	3.9	4.6	1.7	1.7	2.0	-2.0	2.2	-2.2
Co content in liver	0.2	0.2	0.4	0.7	0.6	0.3	-0.3	-0.2	0.2
Cu content in liver	4.5	5.4	5.8	-2.1	-2.1	-2.4	2.4	-2.4	2.4
Fe content in liver	0.2	0.3	0.6	0.5	0.5	0.0	-0.0	-0.8	0.8
K content in liver	2.2	2.1	2.3	-1.4	-1.4	-1.5	1.5	-1.5	1.5
Mg content in liver	2.4	2.5	3.5	-1.2	-1.2	-1.6	1.6	-1.9	1.9
Mn content in liver	0.5	0.5	0.9	-1.0	-0.9	-0.8	0.8	-0.4	0.4
Na content in liver	3.2	3.4	4.4	-2.1	-2.1	-2.0	2.0	-1.4	1.4
Rb content in liver	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.5	-0.6	0.6
Se content in liver	1.3	1.5	2.5	1.6	1.6	1.3	-1.3	0.5	-0.5
Sr content in liver	0.1	0.1	0.2	0.2	0.2	-0.0	0.0	-0.4	0.4
Zn content in liver	0.4	0.4	0.9	0.6	0.6	0.0	0.0	-1.0	1.0
Bone: minimum diameter	1.0	1.8	3.4	-1.8	-1.7	-0.6	0.6	1.4	-1.4
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.1	0.1	-0.1	0.5	-0.5
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	-0.1	0.1
Total zone transitions, hab. session 1	0.9	1.3	2.9	0.2	0.3	0.9	-0.9	1.7	-1.7
Total locomotion distance, hab. session 1	0.8	1.2	3.2	-0.6	-0.5	0.4	-0.4	1.8	-1.8
Locomotion velocity, hab. session 1	0.7	1.0	2.6	-0.1	-0.0	0.6	-0.6	1.6	-1.6
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.5	-0.3	0.3
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	0.7	0.6	-0.6	0.3	-0.3
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.2	0.2	0.3	-0.3	0.3	-0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.4	-0.2	-0.2	0.1	-0.1	0.7	-0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.4	-0.2	-0.2	0.1	-0.2	0.7	-0.7
Novel to familiar place preference ratio	0.6	0.7	1.8	-0.2	-0.1	0.4	-0.4	1.3	-1.3
Novelty place preference	0.3	0.4	1.0	-0.3	-0.2	0.2	-0.2	1.0	-1.0
Time in novel zone, NPP test	0.4	0.5	1.2	-0.1	-0.0	0.4	-0.4	1.1	-1.1
Total zone transitions, NPP test	0.1	0.1	0.2	0.4	0.4	0.3	-0.3	0.1	-0.1
Total locomotion distance, NPP test	0.3	0.4	0.9	-0.6	-0.5	0.0	-0.1	1.0	-1.0
Locomotion velocity, NPP test	0.3	0.5	0.8	-0.8	-0.7	-0.2	0.1	0.9	-0.9
Intraocular pressure	0.3	0.4	0.9	-0.2	-0.2	-0.5	0.5	-0.9	0.9
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.3	0.2	0.2	-0.2	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	0.1	-0.1
Parametrial fat weight	0.0	0.1	0.3	0.1	0.1	-0.1	0.1	-0.5	0.5
Pavlov. Cond. lever latency	0.4	0.5	0.6	0.8	0.8	0.7	-0.7	0.5	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	-0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.3	-0.4	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4	-0.4	0.4
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.4	-0.4	0.4
Pavlov. Cond. lever contacts	1.0	1.2	1.4	-1.2	-1.2	-1.2	1.2	-0.9	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.7	0.6	0.6	0.8	-0.8	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	-0.4	-0.5	-0.5	0.5	-0.6	0.6
Pavlov. Cond. response bias	0.2	0.3	0.4	-0.4	-0.4	-0.5	0.5	-0.6	0.6
Pavlov. Cond. lever latency	2.2	3.0	4.6	2.2	2.1	1.8	-1.8	1.0	-1.0
Pavlov. Cond. magazine entry latency	4.5	5.5	6.1	-2.3	-2.3	-2.5	2.5	-2.3	2.3
Pavlov. Cond. change in total contacts	2.3	3.6	6.6	-2.6	-2.5	-2.0	2.0	-0.7	0.7
Pavlov. Cond. index score	3.1	4.2	5.4	-2.3	-2.3	-2.2	2.2	-1.5	1.5
Pavlov. Cond. latency score	3.2	4.3	5.3	-2.3	-2.3	-2.2	2.2	-1.7	1.7
Pavlov. Cond. lever contacts	2.2	3.0	4.9	-2.2	-2.2	-1.8	1.8	-0.9	0.9
Pavlov. Cond. magazine entry number	2.3	2.9	3.2	1.7	1.7	1.8	-1.8	1.6	-1.6
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.5	0.5	0.1	-0.1	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.5	5.8	-2.4	-2.4	-2.3	2.3	-1.6	1.6
Pavlov. Cond. response bias	3.1	4.2	6.4	-2.5	-2.5	-2.2	2.2	-1.2	1.2
Time in closed arm before self-admin	0.1	0.2	0.2	0.3	0.3	0.4	-0.5	0.5	-0.5
Time in closed arm after self-admin	0.7	0.8	1.4	-0.5	-0.5	-0.8	0.8	-1.2	1.2
Time in open arm before self-admin	1.4	1.5	1.8	-1.3	-1.3	-1.3	1.3	-1.1	1.1
Time in open arm after self-admin	0.4	0.5	0.9	-1.0	-0.9	-0.5	0.5	0.5	-0.5
Bone: periosteal estimation	0.4	0.9	2.2	-1.5	-1.4	-0.8	0.8	0.4	-0.4
Bone: periosteal perimeter	0.4	0.7	1.6	-1.3	-1.2	-0.7	0.7	0.3	-0.3
Bone: post-yield work	0.2	0.2	0.5	-0.5	-0.4	-0.0	-0.0	0.7	-0.7
Progressive ratio test 1 active lever presses	2.4	3.0	3.4	-1.5	-1.6	-1.8	1.8	-1.8	1.8
Progressive ratio test 1 breakpoint	2.7	3.3	3.6	-1.7	-1.7	-1.9	1.9	-1.8	1.8
Progressive ratio test 1 inactive lever presses	2.2	3.1	3.4	-1.6	-1.7	-1.8	1.8	-1.8	1.8
Progressive ratio test 2 active lever presses	1.7	1.9	3.4	-0.8	-0.8	-1.3	1.3	-1.9	1.9
Progressive ratio test 2 breakpoint	1.5	1.7	3.1	-0.7	-0.8	-1.2	1.2	-1.7	1.7
Progressive ratio test 2 inactive lever presses	2.6	4.3	5.2	-1.7	-1.8	-2.1	2.1	-2.3	2.3
Incentive Sensitization - Responses	0.2	0.2	0.6	0.2	0.2	-0.2	0.2	-0.8	0.8
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	0.3	0.3	-0.0	0.1	-0.6	0.6
Sum of active levers in priming session hrs 5-6	3.9	3.6	5.6	1.2	1.3	1.9	-1.9	2.4	-2.4
Progressive ratio	1.1	1.8	2.0	1.4	1.4	1.4	-1.4	1.1	-1.1
Food seeking constrained by brief footshock	0.4	0.5	1.1	-1.0	-1.0	-0.5	0.5	0.4	-0.4
Seeking ratio, punishment vs. effort	1.9	2.8	3.4	-1.8	-1.8	-1.8	1.8	-1.4	1.4
Retroperitoneal fat weight	0.1	0.3	0.6	0.8	0.7	0.3	-0.3	-0.4	0.4
Reaction time number correct	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.1	0.1
Reaction time mean minus median	0.3	0.8	0.8	-0.8	-0.8	-0.9	0.9	-0.9	0.9
Reaction time mean minus median AUC	0.8	2.0	2.3	-1.2	-1.3	-1.5	1.5	-1.5	1.5
Reaction time num false alarms	0.7	1.0	1.4	1.2	1.2	1.1	-1.1	0.6	-0.6
Reaction time num false alarms AUC	0.9	1.4	2.1	1.4	1.4	1.3	-1.3	0.7	-0.7
Reaction time trials correct on left	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.1	0.1
Reaction time trials on left	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.2	0.2
Reaction time mean	0.3	0.5	1.0	-0.3	-0.4	-0.7	0.7	-1.0	1.0
Reaction time mean AUC	0.7	1.0	2.1	-0.4	-0.5	-0.9	0.9	-1.4	1.4
Median of all reaction times	0.2	0.2	0.6	0.1	0.0	-0.3	0.3	-0.8	0.8
Reaction time omissions	0.0	0.0	0.1	0.3	0.3	0.1	-0.1	-0.2	0.2
Reaction time false alarm rate	0.7	0.9	1.5	1.2	1.2	1.0	-1.0	0.3	-0.3
Reaction time premature initiation rate	0.1	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	-0.4
Reaction time premature initiations	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3
Std. dev. reaction times	0.7	1.3	1.6	-0.9	-0.9	-1.1	1.2	-1.3	1.3
Reaction time trials completed	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.2	0.2
Reaction time trials AUC	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	-0.1	0.1
Run reversals in cocaine runway, females	1.3	1.3	2.5	-0.5	-0.6	-1.0	1.0	-1.6	1.6
Run reversals in cocaine runway, males	0.7	0.7	0.9	1.0	0.9	0.9	-0.9	0.6	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	0.1	-0.0	0.0	-0.1	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.3	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	-0.3	-0.3	-0.4	0.4	-0.5	0.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.3	-0.3	0.0	-0.0	0.5	-0.5
Total sessions with >9 infusions	0.4	0.5	0.5	0.6	0.7	0.7	-0.7	0.7	-0.7
Short access day 1 total inactive lever presses	1.3	1.8	1.9	-1.3	-1.3	-1.4	1.4	-1.3	1.3
Short access day 10 total inactive lever presses	1.3	3.2	3.6	-1.9	-1.9	-1.9	1.9	-1.6	1.6
Short access day 1 total infusions	0.7	0.9	1.2	-1.1	-1.1	-1.0	1.0	-0.7	0.7
Short access day 10 total infusions	0.1	0.2	0.3	-0.2	-0.3	-0.4	0.4	-0.5	0.5
Short access total infusions	0.1	0.2	0.3	-0.2	-0.2	-0.4	0.4	-0.6	0.6
Short access day 1 locomotion	0.8	1.0	1.4	1.2	1.2	1.1	-1.1	0.7	-0.7
Short access day 10 total locomotion	0.1	0.2	0.5	-0.7	-0.7	-0.4	0.4	0.2	-0.2
Short access total locomotion	0.2	0.2	0.3	0.3	0.3	0.4	-0.4	0.6	-0.6
One hour access (0.3 mA shock)	0.6	0.7	0.8	-0.9	-0.9	-0.9	0.9	-0.7	0.7
Compulsive drug intake	1.0	1.2	3.1	-0.4	-0.3	0.5	-0.5	1.8	-1.8
One hour access (shock baseline)	0.8	1.2	2.2	-0.6	-0.6	-1.0	1.0	-1.5	1.5
Social response proportion	2.4	2.7	4.6	-2.2	-2.1	-1.8	1.7	-0.7	0.7
Social responses	0.6	0.8	1.0	-0.8	-0.8	-1.0	1.0	-0.9	0.9
Social time	0.1	0.2	0.5	-0.1	-0.1	0.2	-0.2	0.7	-0.7
Soleus weight	1.9	5.7	6.3	2.3	2.3	2.5	-2.5	2.4	-2.4
Bone: stiffness	0.2	0.4	0.8	-0.9	-0.8	-0.3	0.3	0.6	-0.6
Tibialis anterior weight	0.7	2.4	3.7	1.0	1.1	1.5	-1.5	1.9	-1.9
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.0	-0.7	-0.8	-1.0	1.0	-1.4	1.4
Time to tail flick, vehicle, after self-admin	2.0	2.7	3.4	-1.3	-1.4	-1.7	1.7	-1.8	1.8
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	0.4	0.3	-0.3	-0.0	0.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.2	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.4	0.5	-0.7	-0.7	-0.7	0.7	-0.5	0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.4	-0.4	-0.5	0.5	-0.3	0.3
Tibia length	2.1	5.9	7.5	-2.7	-2.7	-2.6	2.6	-1.8	1.8
Ambulatory time before self-admin	0.6	0.8	1.6	-1.3	-1.2	-1.0	0.9	-0.2	0.2
Ambulatory time after self-admin	1.3	1.5	2.7	-1.6	-1.6	-1.3	1.3	-0.5	0.5
Bone: tissue strength	1.8	1.8	3.4	-1.8	-1.8	-1.4	1.4	-0.4	0.4
Total heroin consumption	1.8	2.1	4.8	0.3	0.4	1.2	-1.2	2.2	-2.2
Bone: trabecular number	0.3	0.5	0.5	-0.6	-0.7	-0.7	0.7	-0.7	0.7
Bone: trabecular spacing	0.3	0.4	0.7	-0.9	-0.8	-0.3	0.3	0.6	-0.6
Bone: trabecular thickness	0.6	0.8	1.5	-0.4	-0.4	-0.8	0.8	-1.2	1.2
Bone: trabecular tissue density	1.9	2.8	4.0	2.0	2.0	1.8	-1.8	1.1	-1.1
Water consumed over 24 hours	1.1	1.4	1.7	-1.3	-1.3	-1.3	1.3	-1.0	1.0
Number of responses in last shaping day	0.3	0.4	0.6	-0.8	-0.8	-0.7	0.7	-0.4	0.4