Hub : Genes

Fbxo17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr1_84022775_84023850 0.07 0.05 2.9e-06 0.05 0.05 0.06 0.05 1.4e-06 2.7e-06 1.0e-06 1.3e-06
2 Eye intron excision ratio chr1_84022775_84023850 0.33 0.18 7.9e-03 0.01 0.04 0.04 0.03 2.4e-01 8.6e-02 8.5e-02 1.1e-01
3 PL gene expression Fbxo17 0.03 0.02 1.3e-03 0.02 0.02 0.03 0.02 1.5e-03 9.2e-04 7.6e-04 1.3e-03
4 NAcc gene expression Fbxo17 0.02 0.02 6.4e-03 0.01 0.01 0.01 0.01 2.2e-02 7.4e-03 1.6e-02 3.4e-02
5 OFC gene expression Fbxo17 0.2 0.13 2.6e-03 0.11 0.09 0.08 0.1 1.6e-03 4.8e-03 6.3e-03 2.7e-03
6 BLA intron excision ratio chr1_84022775_84023850 0.09 0.06 1.7e-04 0.07 0.08 0.07 0.07 1.6e-04 6.2e-05 1.4e-04 1.5e-04
7 BLA intron excision ratio chr1_84022815_84023850 0.09 0.06 2.0e-04 0.07 0.08 0.07 0.07 1.9e-04 7.2e-05 1.8e-04 1.6e-04
8 PL intron excision ratio chr1_84022815_84023850 0.18 0.12 2.6e-15 0.15 0.13 0.14 0.15 6.1e-16 4.0e-14 1.2e-15 5.7e-16
9 pVTA intron excision ratio chr1_84022775_84023850 0.08 0.06 8.7e-03 0.06 0.01 0.05 0.06 9.7e-04 1.0e-01 3.1e-03 1.8e-03
10 Brain intron excision ratio chr1_84022815_84023850 0.12 0.07 2.1e-08 0.09 0.08 0.07 0.08 2.2e-08 3.0e-08 1.7e-07 3.8e-08
11 Brain intron excision ratio chr1_84022775_84023850 0.11 0.07 1.3e-07 0.08 0.08 0.07 0.07 1.1e-07 1.1e-07 2.2e-07 1.7e-07
12 NAcc intron excision ratio chr1_84022775_84023850 0.03 0.02 3.7e-03 0.03 0.01 0.01 0.02 4.4e-04 2.4e-02 6.1e-03 2.0e-03
13 pVTA intron excision ratio chr1_84022815_84023850 0.08 0.07 9.0e-03 0.06 0.03 0.06 0.05 1.5e-03 2.8e-02 1.0e-03 2.4e-03
14 Brain intron excision ratio chr1_84020232_84020393 0.03 0.03 6.0e-03 0.03 0.01 0.02 0.02 1.9e-03 3.1e-02 8.0e-03 5.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.9-0.20.0-0.10.10.4-0.20.2-0.5-0.40.2-0.2-0.70.71.0
Area under the delay curve0.10.10.40.1-0.30.3-0.3-0.00.4-0.40.0-0.10.1-0.1-0.0-0.4-0.7
BMI with tail0.10.50.7-0.8-0.60.8-0.80.70.9-0.9-0.7-0.40.5-0.5-0.50.3-0.9
BMI without tail0.10.20.60.10.5-0.10.2-0.3-0.20.20.40.8-0.70.70.6-0.6-0.5
Body weight2.711.415.33.93.4-3.53.6-3.3-3.63.63.23.4-3.63.62.9-2.82.2
Weight adjusted by age0.20.20.3-0.5-0.40.4-0.50.40.5-0.5-0.3-0.50.2-0.2-0.30.3-0.4
Bone surface0.50.92.60.91.1-1.11.2-0.5-1.21.20.50.5-0.80.80.30.21.6
Bone volume0.50.82.40.91.1-1.11.1-0.5-1.21.20.50.5-0.80.80.30.11.6
Breakpoint value in progressive ratio session1.21.34.11.40.4-0.20.0-1.30.1-0.11.21.3-1.21.21.2-1.8-2.0
Number of licking bursts1.51.85.4-1.0-0.90.7-0.71.40.6-0.6-1.4-1.71.7-1.7-1.42.31.1
Context. condit. distance diff. score0.10.10.2-0.4-0.30.2-0.30.30.3-0.3-0.2-0.30.3-0.3-0.20.1-0.3
Locomotion velocity, session 12.62.83.6-1.6-1.91.8-1.91.71.9-1.9-1.6-1.61.7-1.7-1.71.1-1.3
Locomotion distance, session 10.70.91.10.91.0-1.01.0-1.0-1.01.01.01.0-1.01.01.0-0.80.5
Locomotion velocity, session 20.30.40.7-0.8-0.70.6-0.70.70.7-0.7-0.7-0.50.6-0.6-0.70.2-0.3
Locomotion distance, session 20.71.01.9-0.8-1.21.2-1.30.81.3-1.3-0.8-0.70.6-0.6-0.8-0.1-1.4
Locomotion velocity, session 30.70.85.80.20.4-0.70.70.3-0.80.8-0.3-0.30.4-0.4-0.31.32.4
Locomotion distance, session 36.47.08.32.82.9-2.92.8-2.6-2.82.82.62.6-2.72.72.6-1.81.9
Stereotopy head waving bouts, day 30.50.60.9-0.5-0.80.8-0.90.51.0-1.0-0.5-0.60.8-0.8-0.60.5-0.9
Stereotopy head waving duration, day 32.32.83.3-1.6-1.81.8-1.81.71.8-1.8-1.7-1.71.7-1.7-1.71.3-1.0
Locomotion velocity, session 70.20.32.10.20.3-0.50.50.1-0.60.6-0.00.0-0.20.2-0.10.21.4
Locomotion distance, session 70.30.31.40.30.6-0.70.7-0.3-0.80.80.30.3-0.40.40.20.11.2
Stereotopy head waving bouts, day 70.10.10.3-0.2-0.30.3-0.40.10.4-0.4-0.1-0.10.0-0.0-0.2-0.1-0.5
Stereotopy head waving duration, day 71.11.32.1-1.1-1.31.3-1.41.01.4-1.4-1.0-1.00.9-0.9-1.00.4-1.3
Locomotion velocity, session 82.32.83.9-1.5-1.61.4-1.51.91.4-1.4-1.8-1.92.0-2.0-1.91.90.1
Locomotion distance, session 80.60.92.1-0.8-1.01.0-1.20.71.2-1.2-0.6-0.70.6-0.6-0.7-0.0-1.5
Degree of sensitization distance3.33.34.2-2.0-1.91.8-1.81.91.7-1.7-2.0-1.92.0-2.0-2.01.6-0.6
Degree of sensitization stereotypy0.10.11.0-0.0-0.30.4-0.4-0.00.5-0.50.10.0-0.10.10.0-0.4-1.0
Conditioned locomotion1.01.22.90.91.3-1.31.4-0.8-1.41.40.80.8-0.70.70.80.21.7
Cocaine response after cond. corrected0.60.71.10.51.0-1.01.0-0.6-1.11.10.70.6-0.80.80.8-0.21.1
Cocaine response after cond. not corrected1.01.11.60.91.3-1.21.3-0.9-1.31.31.00.8-1.01.01.0-0.31.1
Cocaine response before conditioning1.51.83.11.81.4-1.31.2-1.6-1.11.11.61.4-1.41.41.5-1.1-0.1
Saline control response0.40.62.70.70.30.1-0.1-0.70.2-0.20.70.7-0.80.80.8-1.1-1.6
Bone: connectivity density0.50.71.4-1.0-0.70.6-0.51.00.5-0.5-1.0-1.10.8-0.8-1.21.10.6
Bone: cortical apparent density2.63.44.8-2.0-2.12.1-2.21.62.2-2.2-1.7-1.61.7-1.7-1.70.8-1.9
Bone: cortical area1.82.85.12.31.7-1.61.5-1.9-1.41.41.91.8-1.91.91.6-1.40.1
Bone: cortical porosity0.40.50.7-0.7-0.80.7-0.70.90.7-0.7-0.7-0.70.7-0.7-0.70.4-0.3
Bone: cortical porosity0.50.50.8-0.7-0.90.7-0.80.90.8-0.8-0.7-0.80.7-0.7-0.70.5-0.4
Bone: cortical thickness0.81.32.71.61.2-1.11.0-1.3-1.01.01.31.3-1.31.31.1-0.90.0
Bone: cortical thickness0.10.10.3-0.20.0-0.20.10.1-0.10.1-0.1-0.20.2-0.2-0.20.50.5
Bone: cortical tissue density2.93.95.2-2.2-2.22.2-2.31.82.3-2.3-1.8-1.71.9-1.9-1.90.9-1.9
Condit. Reinf. active minus inactive responses0.20.21.0-0.5-0.20.1-0.20.40.2-0.2-0.4-0.60.7-0.7-0.51.00.2
Condit. Reinf. active-inactive response ratio0.20.20.5-0.2-0.30.2-0.30.30.3-0.3-0.2-0.50.6-0.6-0.40.7-0.2
Condit. Reinf. active responses0.81.02.0-1.4-0.80.7-0.71.10.7-0.7-1.1-1.21.1-1.1-1.21.20.2
Condit. Reinf. inactive responses0.60.72.2-1.5-0.80.9-0.71.00.7-0.7-1.0-0.80.7-0.7-1.00.60.1
Incentive salience index mean0.20.21.1-0.10.3-0.50.50.1-0.50.5-0.0-0.20.1-0.1-0.10.71.1
Condit. Reinf. lever presses0.30.41.30.30.7-0.80.8-0.3-0.80.80.40.3-0.50.50.4-0.21.2
Condit. Reinf. active minus inactive responses3.64.56.22.42.2-2.02.0-2.4-1.91.92.42.4-2.32.32.5-1.90.2
Condit. Reinf. active-inactive response ratio2.42.53.91.61.5-1.21.1-1.9-1.01.02.02.0-1.71.72.0-1.8-0.8
Condit. Reinf. active responses4.25.87.62.82.5-2.42.3-2.7-2.22.22.72.7-2.52.52.8-2.00.4
Condit. Reinf. inactive responses1.11.42.71.61.2-1.11.1-1.4-1.11.11.31.2-1.21.21.2-1.00.2
Condit. Reinf. lever presses6.48.711.13.33.2-3.13.1-3.2-3.13.13.13.1-2.92.93.1-2.01.6
Condit. Reinf. lever reinforcers received5.37.49.33.13.0-2.82.7-3.0-2.72.73.03.0-2.82.83.0-2.11.0
Conditioned reinforcement - actives0.60.61.20.31.1-0.90.9-0.5-0.90.90.50.5-0.50.50.61.01.1
Conditioned reinforcement - inactives2.62.94.11.71.8-1.92.0-1.5-2.02.01.51.5-1.51.51.5-1.21.7
Conditioned locomotion0.91.14.5-1.3-0.50.5-0.61.20.6-0.6-1.0-1.21.3-1.3-0.82.10.6
Patch foraging indifference point 0 sec0.30.40.70.80.8-0.70.7-0.7-0.70.70.70.6-0.60.60.7-0.20.4
Patch foraging indifference point AUC0.91.02.80.0-1.31.3-1.30.51.3-1.3-0.7-0.50.5-0.5-1.1-0.5-1.7
Delay disc. indifference point, 0s delay0.40.42.30.40.10.1-0.2-0.60.3-0.30.60.6-0.60.60.6-1.2-1.5
Delay disc. indifference point, 16s delay0.90.91.31.21.1-1.11.1-1.0-1.01.01.10.8-0.90.91.0-0.50.7
Delay disc. indifference point, 2s delay0.10.10.2-0.3-0.40.3-0.40.20.4-0.4-0.2-0.20.3-0.3-0.2-0.1-0.4
Delay disc. indifference point, 24s delay1.31.31.71.21.0-1.31.3-1.0-1.31.31.01.0-1.11.10.8-1.11.1
Delay disc. indifference point, 4s delay0.00.00.10.10.1-0.00.0-0.10.0-0.00.20.2-0.20.20.1-0.2-0.2
Delay disc. indifference point, 8s delay1.51.52.4-0.8-1.51.4-1.51.01.5-1.5-1.0-1.11.1-1.1-1.10.2-1.5
Indifference point function ln k0.91.33.90.61.4-1.51.5-0.7-1.51.50.80.6-0.60.60.90.62.0
Indifference point function log k0.91.33.90.61.4-1.51.5-0.7-1.51.50.80.6-0.60.60.90.62.0
Patch foraging total patch changes 0 sec0.40.60.90.81.0-0.80.9-0.8-0.90.90.80.7-0.70.70.8-0.30.6
Patch foraging total patch changes 12 sec0.30.41.71.30.3-0.20.2-0.7-0.20.20.60.7-0.60.60.4-1.1-0.6
Patch foraging total patch changes 18 sec0.91.25.70.2-1.21.3-1.30.21.4-1.4-0.4-0.20.3-0.3-0.5-1.2-2.4
Patch foraging total patch changes 24 sec0.50.72.41.50.6-0.60.6-0.9-0.60.60.80.8-0.80.80.6-1.1-0.1
Patch foraging total patch changes 6 sec0.10.20.90.5-0.10.1-0.2-0.40.2-0.20.30.4-0.30.30.2-1.0-1.0
Patch foraging time to switch 0 sec1.11.82.4-1.4-1.51.5-1.41.41.4-1.4-1.4-1.31.4-1.4-1.30.3-0.8
Patch foraging water rate 0 sec0.40.62.9-0.8-0.1-0.10.20.8-0.30.3-0.7-0.70.7-0.7-0.71.41.7
Patch foraging water rate 12 sec1.42.24.90.51.6-2.01.9-1.1-1.92.01.21.3-1.01.01.1-0.62.2
Patch foraging water rate 18 sec0.70.93.7-1.1-0.20.0-0.01.0-0.00.0-0.9-1.01.0-1.0-0.81.91.5
Patch foraging water rate 24 sec0.81.22.70.31.3-1.41.4-0.8-1.41.40.90.7-0.70.71.00.31.6
Patch foraging water rate 6 sec0.60.84.30.40.9-1.11.2-0.3-1.21.20.30.2-0.30.30.30.62.1
Seeking ratio, delayed vs. immediate footshock1.01.11.70.91.0-0.80.9-1.2-0.90.91.11.2-1.31.31.2-1.3-0.0
Distance traveled before self-admin1.92.02.71.61.5-1.41.4-1.6-1.41.41.61.6-1.41.41.5-1.30.4
Distance traveled after self-admin4.75.27.22.52.5-2.32.3-2.5-2.32.32.52.7-2.32.32.4-1.80.9
Extensor digitorum longus weight0.20.71.2-0.7-0.80.8-0.80.90.8-0.8-0.9-1.00.9-0.9-0.91.1-0.0
Bone: elastic displacement0.00.00.1-0.3-0.20.1-0.10.30.1-0.1-0.2-0.20.2-0.2-0.40.30.1
Bone: elastic work2.33.04.01.91.9-2.02.0-1.7-2.02.01.81.8-1.71.71.5-0.91.2
Bone: endosteal estimation0.81.83.11.81.2-1.11.0-1.5-1.01.01.51.5-1.61.61.4-1.5-0.4
Bone: endosteal perimeter0.81.63.01.71.3-1.21.2-1.4-1.21.21.41.3-1.51.51.3-1.10.2
Epididymis fat weight0.00.00.1-0.2-0.20.3-0.30.20.2-0.2-0.2-0.10.1-0.1-0.2-0.0-0.2
Delta time in closed arm before/after self-admin0.80.82.10.51.1-1.11.1-0.5-1.21.20.50.7-0.70.70.60.21.5
Delta time in open arm before/after self-admin0.00.00.00.0-0.10.1-0.1-0.00.1-0.1-0.1-0.2-0.00.0-0.00.1-0.1
Diff in mean of infusions in LGA sessions0.30.32.20.6-0.30.3-0.4-0.50.5-0.50.30.3-0.10.10.3-0.9-1.5
Delay discount exponential model param0.00.00.2-0.20.2-0.10.20.1-0.20.2-0.10.1-0.00.0-0.00.40.5
Extinction: sum of active levers before priming0.90.92.00.90.5-0.20.2-1.1-0.10.10.91.0-1.21.21.1-1.4-1.4
Active lever presses in extinction session 60.20.20.50.50.2-0.10.1-0.5-0.10.10.40.6-0.50.50.3-0.7-0.6
Bone: final force1.62.64.12.01.7-1.71.6-1.8-1.61.61.81.6-1.61.61.5-1.20.6
Bone: final moment2.44.06.42.52.1-2.12.0-2.1-2.02.02.12.1-2.02.01.9-1.40.9
Food consumed during 24 hour testing period0.70.92.40.91.0-1.21.2-0.7-1.21.20.70.5-0.50.50.70.21.6
Glucose0.40.63.6-0.5-0.1-0.10.20.8-0.30.4-0.8-0.60.6-0.6-0.91.01.9
Heart weight0.81.11.31.11.1-1.01.1-1.1-1.11.11.11.1-1.01.01.1-0.60.7
Delay discount hyperbolic model param0.10.10.30.00.3-0.30.3-0.1-0.30.40.00.2-0.10.10.10.30.5
Intermittent access intake day 1-15 change1.01.02.81.20.7-0.70.7-1.1-0.70.71.01.1-1.21.20.8-1.7-0.2
Intermittent access intake escalation0.70.71.60.80.7-0.60.7-0.8-0.70.70.80.9-1.01.00.9-1.3-0.0
Intermittent access intake escalation 22.52.58.01.81.0-0.80.8-1.7-0.70.71.71.8-1.81.81.7-2.8-1.3
Intermitt. access day 1 inactive lever presses1.11.15.00.51.1-1.31.3-0.4-1.41.40.40.4-0.70.70.40.62.2
Intermitt. access day 15 inactive lever presses1.01.15.60.41.0-1.21.3-0.3-1.41.40.30.3-0.30.30.30.82.4
Intermitt. access escalation Index0.10.10.40.10.4-0.10.0-0.40.0-0.10.40.3-0.30.30.50.5-0.6
Intermittent access day 1 total infusions0.70.83.3-0.31.1-1.00.9-0.1-0.90.90.20.00.1-0.10.51.81.8
Intermittent access day 15 total infusions1.21.32.10.81.5-1.41.4-1.0-1.41.41.11.0-0.90.91.2-0.11.2
Intermittent access terminal intake (last 3 days)1.61.82.41.31.6-1.51.5-1.3-1.51.51.41.3-1.21.21.4-0.80.9
Intermittent access total infusions1.21.32.50.51.5-1.51.4-0.8-1.41.41.00.8-0.70.71.10.61.6
Intermittent access day 1 locomotion1.01.06.8-0.41.1-0.90.8-0.0-0.80.90.2-0.10.1-0.10.42.61.7
Intermittent access day 15 total locomotion0.20.31.4-0.20.4-0.40.40.2-0.40.4-0.1-0.20.2-0.2-0.11.21.1
Intermittent access total locomotion0.60.75.2-0.80.2-0.10.10.7-0.10.1-0.6-0.70.7-0.7-0.52.31.2
Intermittent access standard deviation3.84.09.02.21.6-1.61.5-2.2-1.41.42.32.3-2.32.32.2-3.0-0.6
Left kidney weight3.08.412.63.53.1-3.03.1-3.0-3.23.22.82.9-3.03.02.6-1.71.9
Right kidney weight3.910.914.63.83.4-3.33.4-3.6-3.43.43.43.4-3.63.63.2-2.81.5
Cocaine induced anxiety0.10.10.50.1-0.30.4-0.3-0.10.4-0.4-0.0-0.10.2-0.20.1-0.7-0.7
Post-drug Anxiety0.60.71.0-0.7-0.91.0-0.90.61.0-1.0-0.7-0.70.9-0.9-0.70.4-0.8
Baseline Anxiety0.10.11.4-0.40.00.1-0.10.30.1-0.1-0.3-0.10.2-0.2-0.41.20.2
Tail length4.613.816.44.03.8-3.73.8-3.9-3.83.83.83.9-4.14.13.6-3.51.8
Length with tail7.326.835.35.95.3-5.55.5-5.4-5.65.65.25.1-5.45.44.7-4.23.3
Length without tail3.98.413.43.73.0-3.33.2-3.0-3.23.22.92.6-2.82.82.4-1.82.2
Times rat made contact with spout0.50.61.4-0.5-1.01.0-1.00.51.0-1.0-0.6-0.70.6-0.6-0.6-0.0-1.2
Lifetime Intake0.50.61.8-0.11.0-1.00.9-0.3-0.90.90.40.3-0.10.10.61.31.3
Liver weight, left0.00.10.1-0.0-0.30.4-0.30.20.3-0.3-0.3-0.40.1-0.1-0.30.2-0.3
Liver weight, right0.10.10.4-0.10.3-0.40.4-0.1-0.40.40.20.1-0.10.10.10.00.7
Locomotor activity0.50.91.6-0.4-1.21.2-1.10.81.1-1.1-0.9-0.50.5-0.5-0.9-0.8-1.2
Locomotor testing distance0.91.42.2-0.8-1.41.5-1.41.11.4-1.4-1.2-1.01.1-1.1-1.20.1-1.2
Locomotor testing rearing2.43.79.2-1.2-2.32.5-2.41.32.5-2.5-1.5-1.21.3-1.3-1.5-0.6-3.0
Locomotion in novel chamber0.91.02.6-0.9-1.11.3-1.30.81.3-1.3-0.8-0.70.6-0.6-0.90.2-1.6
Locomotion in novel chamber post-restriction0.00.00.10.30.0-0.10.1-0.1-0.10.10.00.1-0.10.1-0.0-0.30.1
Fecal boli incidents, locomotor time 12.83.16.7-2.3-1.31.3-1.22.21.1-1.1-2.1-2.01.9-1.9-2.02.60.9
Change in fecal boli incidents, locomotor task0.70.64.80.5-0.20.5-0.6-0.60.7-0.70.60.4-0.40.40.5-0.9-2.2
Time >=10cm from walls, locomotor time 10.00.00.2-0.1-0.10.1-0.10.10.1-0.1-0.2-0.10.1-0.1-0.20.50.1
Bouts of movement, locomotor time 10.10.10.60.60.10.1-0.1-0.40.1-0.20.30.3-0.40.40.00.0-0.8
Total resting periods, locomotor time 10.10.10.20.50.20.1-0.0-0.20.0-0.00.20.2-0.30.3-0.10.3-0.4
Rest time, locomotor task time 10.10.11.0-0.30.1-0.00.10.3-0.10.1-0.3-0.30.2-0.2-0.31.00.7
Distance moved, locomotor task time 10.20.21.60.30.1-0.20.1-0.4-0.10.10.50.5-0.40.40.6-1.3-0.4
Vertical activity count, locomotor time 11.11.13.11.10.8-0.80.7-1.1-0.60.61.21.3-1.21.21.3-1.8-0.5
Time >=10cm from walls, locomotor time 20.00.00.30.3-0.10.1-0.1-0.20.1-0.10.10.2-0.10.1-0.1-0.1-0.5
Bouts of movement, locomotor time 20.60.64.4-0.2-0.10.2-0.00.5-0.00.0-0.7-0.70.7-0.7-0.92.11.0
Total resting periods, locomotor time 20.60.64.5-0.2-0.20.2-0.10.50.0-0.0-0.7-0.70.7-0.7-1.02.10.9
Rest time, locomotor task time 20.40.40.60.70.7-0.80.7-0.6-0.80.80.60.6-0.60.60.5-0.20.6
Distance moved, locomotor task time 20.30.31.6-0.3-0.60.7-0.70.20.7-0.8-0.2-0.20.2-0.2-0.1-0.6-1.3
Vertical activity count, locomotor time 20.30.32.10.0-0.20.4-0.4-0.20.5-0.50.20.4-0.40.40.2-1.0-1.4
Light reinforcement 10.20.30.6-0.2-0.80.7-0.60.50.5-0.5-0.7-0.40.4-0.4-0.8-0.3-0.3
Light reinforcement 25.47.210.2-3.0-2.52.3-2.23.12.1-2.1-3.1-3.13.0-3.0-2.93.20.4
Bone: marrow area0.91.93.41.81.2-1.11.0-1.5-1.01.01.51.5-1.71.71.4-1.5-0.5
Bone: maximum diameter1.52.74.32.11.8-1.81.8-1.6-1.81.81.61.5-1.71.71.4-0.91.1
Bone: maximum force2.44.17.32.72.1-2.01.9-2.3-1.81.82.32.1-2.22.22.0-1.60.2
Bone: maximum moment3.25.69.83.12.5-2.42.2-2.6-2.22.22.72.5-2.62.62.3-1.80.4
Mean time between licks in bursts0.20.20.40.60.6-0.60.6-0.5-0.60.60.50.3-0.30.30.5-0.10.5
Mean num. licks in bursts0.81.04.40.40.20.0-0.0-0.90.1-0.10.91.1-1.11.10.8-2.1-1.8
Cd content in liver1.11.34.3-0.9-1.21.3-1.40.61.5-1.5-0.6-0.70.7-0.7-0.6-0.3-2.1
Co content in liver1.51.82.9-1.2-1.21.2-1.21.51.2-1.2-1.4-1.51.5-1.5-1.41.7-0.1
Cu content in liver1.82.23.51.41.7-1.71.8-1.3-1.81.81.21.2-1.11.11.3-0.51.9
Fe content in liver0.30.40.6-0.8-0.50.3-0.30.80.2-0.2-0.8-0.70.6-0.6-0.80.70.7
K content in liver1.01.01.51.21.1-1.11.2-0.9-1.21.20.90.9-0.80.80.9-0.51.2
Mg content in liver0.50.52.20.70.7-0.80.9-0.4-0.90.90.30.2-0.20.20.30.31.5
Mn content in liver0.50.60.90.90.7-0.60.6-0.9-0.60.50.90.9-0.80.80.9-0.8-0.2
Na content in liver5.15.46.52.52.4-2.32.3-2.4-2.32.32.42.5-2.52.52.4-2.10.9
Rb content in liver0.00.00.10.20.1-0.10.2-0.1-0.20.2-0.00.00.0-0.0-0.0-0.00.4
Se content in liver2.63.24.3-2.0-2.11.9-1.91.91.9-1.9-1.9-1.81.8-1.8-1.80.8-1.0
Sr content in liver0.50.51.3-0.6-0.50.5-0.60.80.6-0.5-0.7-0.80.8-0.8-0.61.10.1
Zn content in liver0.20.30.8-0.4-0.20.1-0.10.60.00.0-0.6-0.50.6-0.6-0.50.90.9
Bone: minimum diameter4.27.912.53.52.5-2.22.0-3.3-1.91.93.33.3-3.33.33.1-3.3-1.3
Time in familiar zone, hab. session 10.20.20.60.30.3-0.20.2-0.4-0.10.10.40.5-0.70.70.4-0.8-0.3
Time in novel zone, hab. session 10.10.10.3-0.2-0.20.2-0.20.20.2-0.1-0.3-0.30.3-0.3-0.20.50.0
Total zone transitions, hab. session 10.60.82.71.10.10.0-0.1-0.80.2-0.20.80.9-1.01.00.7-1.5-1.6
Total locomotion distance, hab. session 12.12.97.01.91.1-0.90.8-2.0-0.60.62.02.0-2.12.11.9-2.6-1.7
Locomotion velocity, hab. session 10.91.33.41.30.5-0.40.3-1.3-0.20.21.31.3-1.31.31.3-1.8-1.5
Time in familiar zone, hab. session 20.30.40.60.80.5-0.70.6-0.6-0.60.60.60.5-0.60.60.7-0.60.3
Time in novel zone, hab. session 20.60.61.4-1.2-0.80.8-0.70.70.7-0.7-0.8-0.70.7-0.7-0.80.7-0.3
Total zone transitions, hab. session 20.00.00.1-0.1-0.30.1-0.20.10.2-0.2-0.0-0.20.1-0.1-0.1-0.1-0.3
Total locomotion distance, hab. session 20.30.40.80.60.4-0.50.3-0.8-0.30.30.90.6-0.70.70.8-0.9-0.6
Locomotion velocity, hab. session 20.30.40.80.60.4-0.40.3-0.8-0.20.20.80.6-0.60.60.8-0.9-0.6
Novel to familiar place preference ratio1.01.03.80.40.4-0.20.2-1.0-0.20.21.01.3-1.21.21.0-1.9-1.4
Novelty place preference0.80.93.20.40.5-0.30.3-1.0-0.30.30.91.3-1.11.10.9-1.8-1.1
Time in novel zone, NPP test0.60.62.50.20.2-0.10.1-0.7-0.10.10.71.1-0.90.90.7-1.6-1.2
Total zone transitions, NPP test0.10.20.3-0.5-0.50.4-0.50.60.4-0.4-0.5-0.60.3-0.3-0.50.1-0.1
Total locomotion distance, NPP test1.01.42.91.10.9-0.80.7-1.4-0.60.61.51.4-1.41.41.4-1.7-0.9
Locomotion velocity, NPP test1.41.93.61.41.2-1.00.9-1.6-0.80.81.71.6-1.71.71.6-1.9-0.9
Intraocular pressure0.10.10.60.0-0.0-0.00.10.4-0.10.1-0.4-0.30.2-0.2-0.50.30.7
Delta distance traveled before/after self-admin0.30.30.50.70.6-0.40.5-0.6-0.50.50.50.7-0.70.70.4-0.40.1
Delta ambulatory time before/after self-admin0.70.81.31.01.0-0.80.8-1.0-0.80.81.01.1-1.11.10.9-0.6-0.1
Parametrial fat weight0.30.71.3-0.8-0.70.5-0.51.00.4-0.4-1.0-1.01.0-1.0-0.91.10.6
Pavlov. Cond. lever latency0.20.20.4-0.6-0.60.5-0.50.40.5-0.5-0.4-0.40.5-0.5-0.50.5-0.3
Pavlov. Cond. magazine entry latency0.10.10.5-0.2-0.10.0-0.10.40.0-0.0-0.3-0.40.4-0.4-0.30.70.5
Pavlov. Cond. change in total contacts0.00.00.10.10.2-0.20.2-0.0-0.20.20.0-0.0-0.10.10.00.20.3
Pavlov. Cond. index score0.00.10.20.30.3-0.30.3-0.1-0.30.30.10.0-0.10.10.10.10.4
Pavlov. Cond. latency score0.10.10.20.50.4-0.40.4-0.2-0.40.40.20.2-0.30.30.3-0.10.4
Pavlov. Cond. lever contacts0.91.11.41.21.2-1.21.1-0.9-1.21.20.90.9-1.01.01.0-0.70.8
Pavlov. Cond. magazine entry number0.00.00.20.10.0-0.10.1-0.2-0.10.10.20.2-0.30.30.1-0.4-0.1
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.7-0.50.6-0.60.30.6-0.6-0.3-0.20.3-0.3-0.3-0.1-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.30.60.6-0.50.5-0.3-0.50.50.30.3-0.40.40.4-0.00.6
Pavlov. Cond. response bias0.10.20.30.40.5-0.50.5-0.3-0.50.50.30.3-0.30.30.4-0.10.5
Pavlov. Cond. lever latency3.04.06.3-2.5-2.12.1-2.02.22.0-2.0-2.0-2.22.0-2.0-2.11.6-1.0
Pavlov. Cond. magazine entry latency2.42.85.01.51.9-2.02.1-1.4-2.12.11.31.4-1.31.31.3-0.32.2
Pavlov. Cond. change in total contacts5.37.310.33.22.8-2.72.6-3.1-2.62.52.93.0-2.82.82.9-2.30.7
Pavlov. Cond. index score2.93.74.92.22.2-2.22.2-1.9-2.22.21.82.0-1.81.81.8-1.11.6
Pavlov. Cond. latency score2.93.64.72.12.1-2.12.2-1.8-2.22.21.81.9-1.71.71.8-1.01.7
Pavlov. Cond. lever contacts2.83.85.62.42.1-2.02.0-2.1-1.91.92.02.1-1.91.92.0-1.50.9
Pavlov. Cond. magazine entry number1.31.62.8-1.2-1.51.5-1.61.01.6-1.6-1.0-1.11.0-1.0-1.00.3-1.7
Pavlov. Cond. intertrial magazine entries0.50.71.3-0.9-0.70.5-0.50.90.4-0.4-0.9-1.01.0-1.0-0.91.10.6
Pavlov. Cond. lever-magazine prob. diff.3.34.25.42.32.3-2.32.3-2.0-2.32.32.02.1-1.91.92.0-1.21.6
Pavlov. Cond. response bias3.34.46.22.52.3-2.22.2-2.2-2.22.22.12.2-2.02.02.2-1.41.2
Time in closed arm before self-admin0.00.00.2-0.0-0.10.0-0.20.10.3-0.30.0-0.20.4-0.40.0-0.1-0.3
Time in closed arm after self-admin0.60.62.00.30.9-1.00.9-0.3-0.90.90.50.4-0.10.10.60.81.4
Time in open arm before self-admin1.11.21.51.11.1-1.11.2-1.1-1.21.21.01.2-1.21.20.9-1.00.7
Time in open arm after self-admin0.80.91.91.20.6-0.50.6-1.1-0.60.60.91.0-1.41.40.7-1.3-0.5
Bone: periosteal estimation1.63.36.32.51.8-1.51.5-2.1-1.41.42.02.0-2.22.21.8-1.8-0.3
Bone: periosteal perimeter1.32.23.61.91.4-1.31.3-1.7-1.21.21.71.6-1.81.81.5-1.4-0.2
Bone: post-yield work0.40.60.90.80.7-0.60.5-1.0-0.50.40.90.8-0.90.90.9-0.8-0.4
Progressive ratio test 1 active lever presses2.72.95.11.02.3-2.12.0-1.3-2.02.01.51.4-1.31.31.80.72.0
Progressive ratio test 1 breakpoint3.13.35.41.42.3-2.22.2-1.6-2.22.21.71.6-1.51.51.90.11.9
Progressive ratio test 1 inactive lever presses1.01.13.30.31.3-1.21.2-0.5-1.31.30.50.4-0.50.50.61.41.8
Progressive ratio test 2 active lever presses1.41.53.70.51.6-1.51.5-0.8-1.51.50.80.8-0.70.71.01.01.9
Progressive ratio test 2 breakpoint1.51.74.70.61.7-1.61.6-0.8-1.71.70.80.8-0.70.71.01.12.2
Progressive ratio test 2 inactive lever presses3.13.65.41.72.3-2.32.3-1.7-2.32.31.71.6-1.61.61.7-0.02.1
Incentive Sensitization - Responses0.20.21.2-0.00.3-0.30.40.0-0.50.5-0.2-0.10.1-0.1-0.30.81.1
Incentive Sensitization - Breakpoint0.20.20.8-0.20.0-0.10.20.2-0.20.2-0.4-0.30.3-0.3-0.50.80.9
Sum of active levers in priming session hrs 5-61.41.49.50.3-0.91.1-1.3-0.21.4-1.40.20.2-0.00.00.0-1.4-3.1
Progressive ratio0.80.91.5-0.8-1.21.1-1.20.81.2-1.2-0.8-1.00.6-0.6-0.80.2-1.1
Food seeking constrained by brief footshock2.22.74.42.11.6-1.41.3-2.0-1.21.21.92.0-1.71.71.9-1.6-0.5
Seeking ratio, punishment vs. effort2.32.94.01.82.0-1.92.0-1.8-1.91.91.71.8-1.31.31.7-0.71.2
Retroperitoneal fat weight0.72.33.9-1.5-1.71.5-1.41.71.3-1.3-1.9-1.51.6-1.6-2.01.10.1
Reaction time number correct0.10.10.2-0.10.4-0.40.3-0.4-0.30.30.40.3-0.30.30.4-0.00.2
Reaction time mean minus median0.30.40.90.70.7-0.80.8-0.6-0.90.90.60.5-0.40.40.5-0.20.9
Reaction time mean minus median AUC0.70.92.30.91.0-1.11.2-0.8-1.31.30.70.6-0.50.50.50.21.5
Reaction time num false alarms0.81.11.9-0.2-0.91.1-1.21.21.2-1.2-1.1-1.21.0-1.0-1.01.4-0.7
Reaction time num false alarms AUC1.11.62.6-0.4-1.11.3-1.41.41.4-1.4-1.3-1.41.3-1.3-1.21.6-0.7
Reaction time trials correct on left0.10.10.2-0.10.4-0.40.3-0.4-0.30.30.40.3-0.30.30.4-0.00.2
Reaction time trials on left0.10.10.1-0.10.4-0.40.3-0.3-0.30.30.40.3-0.20.20.30.00.2
Reaction time mean0.10.21.1-0.00.2-0.30.30.3-0.30.3-0.2-0.30.3-0.3-0.10.71.1
Reaction time mean AUC0.30.42.2-0.20.2-0.30.30.5-0.40.4-0.4-0.50.5-0.5-0.31.11.5
Median of all reaction times0.20.20.7-0.3-0.10.0-0.00.6-0.00.0-0.5-0.50.5-0.5-0.30.80.8
Reaction time omissions0.10.20.8-0.3-0.20.2-0.20.40.3-0.3-0.3-0.60.4-0.4-0.30.90.1
Reaction time false alarm rate1.11.52.2-0.4-1.11.2-1.31.41.3-1.2-1.4-1.41.3-1.3-1.31.5-0.5
Reaction time premature initiation rate0.00.00.10.2-0.10.1-0.2-0.00.2-0.20.00.00.0-0.0-0.10.1-0.3
Reaction time premature initiations0.00.00.10.10.0-0.1-0.0-0.20.0-0.00.20.1-0.00.00.00.1-0.3
Std. dev. reaction times0.40.51.70.80.8-0.90.9-0.5-0.90.90.40.3-0.20.20.40.21.3
Reaction time trials completed0.10.10.1-0.10.4-0.40.3-0.3-0.30.30.40.3-0.20.20.30.00.2
Reaction time trials AUC0.00.00.1-0.10.3-0.30.3-0.2-0.20.20.30.2-0.10.10.30.10.2
Run reversals in cocaine runway, females0.70.73.6-0.70.1-0.30.40.6-0.50.5-0.6-0.60.6-0.6-0.61.61.9
Run reversals in cocaine runway, males0.60.60.9-0.4-0.90.8-0.80.80.8-0.8-0.8-0.81.0-1.0-0.80.3-0.7
Latency to leave start box in cocaine runway0.10.10.20.2-0.50.2-0.20.20.2-0.2-0.2-0.30.1-0.1-0.5-0.1-0.2
Latency to leave start box in cocaine runway, F0.50.61.1-0.4-1.00.9-0.90.60.9-0.9-0.6-0.80.7-0.7-0.80.1-0.8
Latency to leave start box in cocaine runway, M0.20.20.30.20.4-0.50.5-0.2-0.50.50.10.2-0.50.50.00.30.6
Std. dev. time between licks in bursts0.40.51.00.90.5-0.40.4-0.9-0.40.30.80.6-0.90.90.7-1.0-0.5
Total sessions with >9 infusions0.10.21.5-0.50.4-0.20.10.1-0.00.00.1-0.00.1-0.10.41.20.1
Short access day 1 total inactive lever presses0.60.71.70.71.0-1.01.1-0.6-1.11.10.60.5-0.50.50.50.41.3
Short access day 10 total inactive lever presses0.40.51.70.30.8-0.80.9-0.3-0.90.90.40.3-0.30.30.40.51.3
Short access day 1 total infusions0.60.61.10.41.1-0.91.0-0.6-1.01.00.70.6-0.70.70.80.30.9
Short access day 10 total infusions0.20.21.8-0.50.4-0.30.20.2-0.20.2-0.1-0.20.4-0.40.11.40.7
Short access total infusions0.30.43.1-0.50.4-0.20.20.2-0.20.2-0.2-0.30.4-0.40.11.70.9
Short access day 1 locomotion1.21.32.3-1.0-1.11.3-1.21.11.2-1.2-1.2-1.21.1-1.1-1.11.5-0.6
Short access day 10 total locomotion0.50.61.50.21.2-0.90.8-0.5-0.80.80.60.4-0.50.51.01.20.7
Short access total locomotion0.40.44.8-0.50.30.1-0.10.30.1-0.1-0.3-0.50.4-0.40.02.20.3
One hour access (0.3 mA shock)1.21.42.40.91.6-1.41.3-1.1-1.31.31.31.2-1.01.01.4-0.20.8
Compulsive drug intake0.30.31.30.60.10.0-0.1-0.50.2-0.20.50.5-0.60.60.4-1.0-1.2
One hour access (shock baseline)0.50.61.80.11.0-1.01.0-0.4-1.01.00.50.4-0.40.40.70.31.3
Social response proportion4.44.76.71.62.4-2.42.2-2.4-2.22.22.52.3-2.22.22.6-1.90.8
Social responses0.20.31.2-0.40.5-0.60.7-0.3-0.70.80.20.3-0.30.30.3-0.21.1
Social time0.30.41.9-0.10.2-0.10.2-0.7-0.20.20.50.8-0.70.70.5-1.4-0.6
Soleus weight1.23.55.5-1.6-2.22.2-2.31.72.3-2.3-1.6-1.71.7-1.7-1.60.6-2.2
Bone: stiffness1.11.83.51.91.3-1.21.0-1.5-0.90.91.61.4-1.51.51.4-1.4-0.4
Tibialis anterior weight0.10.42.5-0.3-0.50.7-0.7-0.00.8-0.8-0.00.0-0.00.00.1-0.6-1.6
Time to tail flick, vehicle, before self-admin0.40.41.30.40.7-0.80.8-0.3-0.80.80.40.2-0.40.40.30.61.1
Time to tail flick, vehicle, after self-admin0.50.51.70.40.9-1.00.9-0.4-0.90.90.40.5-0.40.40.50.31.3
Time to tail flick, test, before self-admin0.00.00.10.30.1-0.20.1-0.2-0.10.10.20.2-0.20.20.00.0-0.1
Time to tail flick, test, after self-admin0.10.10.4-0.10.4-0.30.3-0.1-0.30.30.10.00.0-0.00.20.70.5
Delta time to tail flick, vehicle, before/after SA0.10.10.20.10.4-0.40.4-0.3-0.30.30.20.4-0.20.20.4-0.30.3
Delta time to tail flick, test, before/after SA0.10.00.3-0.20.2-0.20.20.0-0.20.2-0.0-0.00.1-0.10.20.20.5
Tibia length2.26.29.23.02.8-2.72.7-2.4-2.72.72.42.5-2.42.42.3-1.51.8
Ambulatory time before self-admin1.11.11.81.31.0-1.01.0-1.2-0.90.91.11.2-1.01.01.1-1.10.2
Ambulatory time after self-admin5.05.46.92.52.5-2.42.3-2.6-2.32.32.62.6-2.42.42.5-2.00.8
Bone: tissue strength3.93.74.92.22.1-1.91.9-2.1-1.81.82.12.1-2.12.12.1-1.60.5
Total heroin consumption1.72.07.71.60.20.1-0.2-1.40.3-0.31.31.5-1.41.41.3-2.6-2.8
Bone: trabecular number0.10.20.50.30.5-0.50.5-0.2-0.50.50.20.2-0.40.40.1-0.10.7
Bone: trabecular spacing1.41.82.71.61.1-1.11.0-1.6-0.90.91.61.6-1.51.51.6-1.6-0.6
Bone: trabecular thickness0.30.42.1-0.20.1-0.20.30.5-0.40.4-0.5-0.50.3-0.3-0.61.11.4
Bone: trabecular tissue density2.33.34.2-2.0-2.12.0-1.91.91.9-1.9-2.0-1.81.8-1.8-2.01.0-1.0
Water consumed over 24 hours1.01.31.71.21.2-1.31.3-1.1-1.31.31.10.8-1.11.11.1-0.51.1
Number of responses in last shaping day2.52.53.11.81.6-1.71.6-1.7-1.61.61.71.6-1.71.71.5-1.70.8