Fbxo17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	intron excision ratio	chr1_93150343_93151378	0.2	0.12	6.3e-05	0.12	-0.01	0.09	0.02	1.1e-05	7.0e-01	1.5e-04	3.8e-02
2	BLA	intron excision ratio	chr1_93150343_93151378	0.09	0.07	1.5e-04	0.07	0.07	0.07	0.03	2.3e-04	1.9e-04	1.0e-04	1.3e-02
3	BLA	intron excision ratio	chr1_93150303_93151378	0.1	0.07	1.2e-04	0.06	0.07	0.07	0.02	3.6e-04	1.6e-04	9.7e-05	2.0e-02
4	PL	intron excision ratio	chr1_93150303_93151378	0.07	0.05	1.4e-06	0.06	0.05	0.06	0.07	3.3e-07	5.9e-06	1.5e-07	1.0e-07
5	Brain	intron excision ratio	chr1_93150303_93151378	0.11	0.07	4.8e-08	0.08	0.08	0.07	0.08	6.3e-08	1.4e-07	2.4e-07	8.4e-08
6	Brain	intron excision ratio	chr1_93150343_93151378	0.12	0.08	5.8e-09	0.09	0.09	0.08	0.09	6.9e-09	1.6e-08	3.3e-08	9.0e-09
7	Eye	intron excision ratio	chr1_93150303_93151378	0.33	0.18	5.2e-03	0.03	0.1	0.06	0.07	1.0e-01	1.5e-02	5.1e-02	3.2e-02
8	PL	intron excision ratio	chr1_93150343_93151378	0.19	0.11	4.4e-16	0.16	0.07	0.16	0.07	5.1e-17	5.6e-08	3.9e-17	1.6e-08
9	PL	gene expression	Fbxo17	0.02	0.02	8.6e-03	0.02	0.01	0.01	0.01	4.8e-03	8.2e-03	1.4e-02	2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.0	0.0	0.1	-0.2	-0.0	0.0	0.2	0.1	-0.1	-0.3	-0.3	0.3
Area under the delay curve	0.1	0.1	0.5	-0.1	-0.1	0.1	-0.1	-0.0	0.0	0.3	0.2	-0.7
BMI with tail	0.1	0.5	1.5	-0.2	-0.8	0.8	0.4	0.3	-0.3	1.0	-0.6	-1.2
BMI without tail	0.5	1.5	1.8	1.3	1.3	-1.3	-1.3	-1.3	1.3	-1.2	1.3	0.5
Body weight	2.2	9.7	11.2	3.0	3.3	-3.3	-3.2	-3.2	3.2	-3.3	3.2	1.8
Weight adjusted by age	0.0	0.1	0.3	0.2	-0.1	0.1	-0.1	0.1	-0.1	0.3	0.0	-0.5
Bone surface	0.4	0.7	1.7	0.6	1.0	-1.0	-0.7	-0.7	0.7	-1.3	0.6	0.9
Bone volume	0.5	0.8	1.7	0.7	1.0	-1.0	-0.7	-0.8	0.8	-1.3	0.7	1.1
Breakpoint value in progressive ratio session	1.3	1.6	4.1	1.5	0.8	-0.8	-1.4	-1.3	1.3	0.0	1.2	-2.0
Number of licking bursts	1.0	1.6	2.6	-1.3	-1.1	1.1	1.4	1.6	-1.6	0.6	-1.6	0.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.0	-0.3	0.3	0.2	0.4	-0.4	0.3	-0.4	-0.2
Locomotion velocity, session 1	2.4	2.6	3.4	-1.4	-1.7	1.7	1.6	1.5	-1.5	1.8	-1.6	-1.5
Locomotion distance, session 1	0.8	1.0	1.2	1.0	1.0	-1.0	-1.0	-1.1	1.1	-0.9	0.9	0.7
Locomotion velocity, session 2	0.3	0.4	0.5	-0.6	-0.7	0.7	0.7	0.6	-0.6	0.7	-0.7	-0.3
Locomotion distance, session 2	0.7	1.0	1.9	-0.8	-1.1	1.1	0.8	0.6	-0.6	1.3	-0.8	-1.4
Locomotion velocity, session 3	0.9	1.0	7.4	-0.3	0.3	-0.3	0.3	0.3	-0.3	-0.9	-0.3	2.7
Locomotion distance, session 3	6.7	7.3	8.2	2.8	2.8	-2.9	-2.7	-2.7	2.7	-2.9	2.6	2.2
Stereotopy head waving bouts, day 3	0.5	0.5	1.5	-0.4	-0.7	0.7	0.5	0.6	-0.6	0.9	-0.6	-1.2
Stereotopy head waving duration, day 3	2.4	2.8	3.2	-1.6	-1.8	1.8	1.7	1.7	-1.7	1.8	-1.7	-1.4
Locomotion velocity, session 7	0.3	0.3	2.0	-0.1	0.3	-0.3	0.0	-0.1	0.1	-0.6	0.1	1.4
Locomotion distance, session 7	0.3	0.4	1.7	0.3	0.5	-0.5	-0.3	-0.4	0.4	-0.8	0.3	1.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.9	-0.2	-0.7	0.7	0.4	0.6	-0.6	1.0	-0.5	-1.4
Stereotopy head waving duration, day 7	1.2	1.4	2.7	-0.8	-1.2	1.2	0.9	1.1	-1.1	1.4	-1.0	-1.6
Locomotion velocity, session 8	2.3	2.7	3.5	-1.7	-1.7	1.7	1.9	1.9	-1.9	1.4	-1.9	0.1
Locomotion distance, session 8	0.6	0.9	2.0	-0.4	-1.0	1.0	0.7	0.8	-0.8	1.3	-0.8	-1.4
Degree of sensitization distance	3.3	3.4	4.4	-2.1	-1.9	1.9	2.0	1.9	-1.9	1.7	-1.9	-0.7
Degree of sensitization stereotypy	0.1	0.2	1.1	0.3	-0.2	0.2	-0.1	0.0	-0.0	0.5	-0.0	-1.0
Conditioned locomotion	1.2	1.4	2.6	1.4	1.3	-1.3	-1.1	-0.9	0.9	-1.6	0.8	1.1
Cocaine response after cond. corrected	0.6	0.7	1.2	0.7	0.9	-0.9	-0.7	-0.8	0.8	-1.1	0.7	0.8
Cocaine response after cond. not corrected	0.8	1.0	1.7	0.8	1.1	-1.1	-0.9	-0.9	0.9	-1.3	1.0	0.7
Cocaine response before conditioning	1.3	1.6	2.2	1.3	1.3	-1.3	-1.5	-1.3	1.3	-1.0	1.5	-0.5
Saline control response	0.2	0.3	1.8	0.4	-0.1	0.1	-0.3	-0.3	0.3	0.6	0.2	-1.4
Bone: connectivity density	0.3	0.4	0.7	-0.7	-0.6	0.6	0.8	0.8	-0.8	0.3	-0.9	0.0
Bone: cortical apparent density	2.8	3.8	5.1	-1.6	-2.1	2.1	1.9	1.8	-1.8	2.3	-1.8	-2.0
Bone: cortical area	2.1	3.3	4.2	2.0	1.9	-1.9	-2.0	-2.0	2.0	-1.5	2.0	0.4
Bone: cortical porosity	0.3	0.3	0.4	-0.3	-0.6	0.6	0.4	0.5	-0.5	0.6	-0.6	0.5
Bone: cortical porosity	0.3	0.4	0.4	-0.5	-0.6	0.6	0.5	0.6	-0.6	0.6	-0.6	0.6
Bone: cortical thickness	1.3	2.2	3.3	1.8	1.5	-1.5	-1.7	-1.6	1.6	-1.2	1.5	0.3
Bone: cortical thickness	0.0	0.0	0.2	0.1	0.1	-0.1	-0.1	-0.0	0.0	-0.3	-0.0	0.5
Bone: cortical tissue density	3.1	4.2	5.4	-1.8	-2.2	2.2	2.0	1.9	-1.9	2.3	-1.9	-2.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.4	-0.3	0.3	0.4	0.6	-0.6	0.1	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	-0.3	0.3	0.3	0.4	-0.4	0.3	-0.3	-0.2
Condit. Reinf. active responses	0.8	1.0	1.5	-1.0	-0.9	0.9	1.1	1.2	-1.2	0.6	-1.1	0.5
Condit. Reinf. inactive responses	0.6	0.8	1.0	-1.0	-0.9	0.9	0.9	1.0	-1.0	0.7	-1.0	0.2
Incentive salience index mean	0.2	0.2	1.6	-0.1	0.2	-0.2	0.1	0.2	-0.2	-0.6	-0.1	1.2
Condit. Reinf. lever presses	0.3	0.4	1.2	0.3	0.7	-0.7	-0.4	-0.3	0.3	-1.0	0.4	1.1
Condit. Reinf. active minus inactive responses	3.4	4.4	6.8	2.6	2.1	-2.1	-2.4	-2.2	2.2	-1.8	2.2	-0.1
Condit. Reinf. active-inactive response ratio	2.4	2.7	4.7	2.2	1.5	-1.5	-1.9	-1.8	1.8	-1.0	1.7	-1.2
Condit. Reinf. active responses	4.0	5.6	8.2	2.9	2.5	-2.5	-2.7	-2.5	2.5	-2.1	2.4	0.4
Condit. Reinf. inactive responses	0.9	1.2	1.7	1.2	1.2	-1.2	-1.3	-1.1	1.1	-1.0	1.2	0.4
Condit. Reinf. lever presses	6.3	8.8	10.6	3.3	3.1	-3.1	-3.1	-3.1	3.1	-3.0	2.9	1.4
Condit. Reinf. lever reinforcers received	5.2	7.2	9.8	3.1	2.9	-2.9	-3.0	-2.8	2.8	-2.6	2.7	0.8
Conditioned reinforcement - actives	0.2	0.4	2.6	0.2	0.0	-0.0	0.2	0.4	-0.4	-0.4	-0.5	1.6
Conditioned reinforcement - inactives	1.4	2.1	6.4	1.1	1.4	-1.4	-0.9	-0.9	0.9	-1.9	0.9	2.5
Conditioned locomotion	1.3	1.7	2.7	-0.9	-1.3	1.3	1.4	1.5	-1.5	1.0	-1.7	0.8
Patch foraging indifference point 0 sec	0.2	0.4	0.6	0.6	0.8	-0.8	-0.7	-0.7	0.7	-0.8	0.7	-0.1
Patch foraging indifference point AUC	1.0	1.5	2.9	-1.3	-1.3	1.3	0.9	0.6	-0.6	1.7	-0.9	-1.7
Delay disc. indifference point, 0s delay	0.4	0.5	3.2	0.1	-0.1	0.1	-0.3	-0.3	0.3	0.5	0.5	-1.8
Delay disc. indifference point, 16s delay	1.0	1.2	1.5	1.1	1.2	-1.2	-1.2	-0.9	0.9	-1.1	1.1	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.2	-0.4	0.4	0.3	0.3	-0.3	0.4	-0.4	-0.5
Delay disc. indifference point, 24s delay	1.2	1.4	2.1	0.5	1.2	-1.2	-1.0	-1.1	1.1	-1.4	1.3	1.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.4	0.0	-0.0	-0.2	-0.2	0.2	0.1	-0.1	-0.6
Delay disc. indifference point, 8s delay	1.3	1.5	2.4	-1.3	-1.3	1.3	1.1	1.1	-1.1	1.5	-0.8	-1.5
Indifference point function ln k	0.6	1.1	2.5	1.2	1.2	-1.2	-0.8	-0.6	0.6	-1.6	0.7	1.3
Indifference point function log k	0.6	1.1	2.5	1.2	1.2	-1.2	-0.8	-0.6	0.6	-1.6	0.7	1.3
Patch foraging total patch changes 0 sec	0.3	0.6	0.8	0.7	0.9	-0.9	-0.7	-0.7	0.7	-0.9	0.8	0.0
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	0.3	0.3	-0.3	-0.5	-0.6	0.6	-0.1	0.4	-0.5
Patch foraging total patch changes 18 sec	1.2	1.8	9.4	-1.1	-1.1	1.1	0.7	0.3	-0.3	1.7	-0.4	-3.1
Patch foraging total patch changes 24 sec	0.3	0.4	0.7	0.3	0.6	-0.6	-0.7	-0.8	0.8	-0.5	0.6	-0.8
Patch foraging total patch changes 6 sec	0.1	0.2	1.3	-0.0	0.0	-0.0	-0.2	-0.4	0.4	0.2	0.3	-1.1
Patch foraging time to switch 0 sec	0.8	1.6	2.6	-1.6	-1.4	1.4	1.4	1.2	-1.2	1.3	-1.2	0.1
Patch foraging water rate 0 sec	0.2	0.4	0.6	-0.7	-0.3	0.3	0.7	0.8	-0.8	-0.3	-0.8	0.6
Patch foraging water rate 12 sec	0.9	2.0	4.0	1.0	1.6	-1.6	-1.0	-1.2	1.2	-2.0	1.5	1.2
Patch foraging water rate 18 sec	0.3	0.5	0.9	-0.5	-0.4	0.4	0.8	1.0	-1.0	-0.2	-1.0	0.9
Patch foraging water rate 24 sec	0.6	0.9	2.0	1.0	1.1	-1.1	-0.7	-0.7	0.7	-1.4	0.9	0.2
Patch foraging water rate 6 sec	0.3	0.5	1.7	0.2	0.8	-0.7	-0.3	-0.2	0.2	-1.2	0.2	1.3
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.5	1.0	1.0	-1.0	-1.1	-1.2	1.2	-0.8	1.1	0.2
Distance traveled before self-admin	2.2	2.8	3.7	1.9	1.7	-1.7	-1.8	-1.8	1.8	-1.6	1.6	1.0
Distance traveled after self-admin	2.5	3.0	4.6	2.2	1.7	-1.7	-1.9	-2.0	2.0	-1.6	1.4	0.8
Extensor digitorum longus weight	0.2	0.7	1.1	-0.6	-0.9	0.9	0.9	1.0	-1.0	0.7	-1.0	-0.6
Bone: elastic displacement	0.0	0.0	0.1	-0.2	-0.1	0.1	0.2	0.1	-0.1	0.0	-0.3	-0.1
Bone: elastic work	2.7	3.6	4.3	1.8	2.0	-2.0	-1.9	-2.0	2.0	-2.1	1.7	1.2
Bone: endosteal estimation	0.6	1.4	2.0	1.1	1.1	-1.1	-1.3	-1.4	1.4	-0.8	1.4	-0.4
Bone: endosteal perimeter	0.6	1.3	1.7	1.1	1.2	-1.2	-1.2	-1.3	1.3	-1.0	1.3	0.5
Epididymis fat weight	0.0	0.1	0.5	0.1	0.2	-0.2	-0.1	-0.2	0.2	-0.3	-0.1	0.7
Delta time in closed arm before/after self-admin	0.3	0.3	1.7	0.1	0.1	-0.1	0.2	0.2	-0.2	-0.6	-0.3	1.3
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.7	0.3	-0.3	-0.5	-0.4	0.4	-0.2	0.2	-0.5
Diff in mean of infusions in LGA sessions	0.2	0.2	1.2	-0.4	-0.2	0.2	-0.1	-0.2	0.2	0.6	0.5	-1.1
Delay discount exponential model param	0.0	0.1	0.4	-0.0	-0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.6
Extinction: sum of active levers before priming	1.8	1.9	3.1	1.3	1.3	-1.4	-1.6	-1.6	1.6	-0.9	1.8	-0.6
Active lever presses in extinction session 6	0.2	0.2	0.8	0.5	0.1	-0.1	-0.4	-0.4	0.4	0.2	0.2	-0.9
Bone: final force	1.6	2.5	3.0	1.5	1.7	-1.7	-1.7	-1.7	1.7	-1.5	1.7	1.0
Bone: final moment	2.5	4.0	4.7	2.0	2.1	-2.1	-2.1	-2.2	2.2	-2.0	2.1	1.1
Food consumed during 24 hour testing period	0.4	0.6	1.4	0.5	0.9	-0.9	-0.6	-0.5	0.5	-1.2	0.6	1.0
Glucose	0.4	0.7	4.1	-0.7	-0.0	0.0	0.6	0.6	-0.6	-0.6	-0.5	2.0
Heart weight	1.1	1.7	2.0	1.2	1.4	-1.4	-1.4	-1.4	1.4	-1.4	1.4	0.7
Delay discount hyperbolic model param	0.1	0.1	0.4	0.1	0.2	-0.2	-0.0	-0.1	0.1	-0.3	0.0	0.6
Intermittent access intake day 1-15 change	0.2	0.5	1.6	0.5	0.6	-0.6	-0.6	-0.5	0.5	-0.5	0.6	1.3
Intermittent access intake escalation	0.1	0.3	1.1	0.5	0.4	-0.4	-0.5	-0.4	0.4	-0.3	0.4	1.0
Intermittent access intake escalation 2	1.3	1.4	2.4	1.3	1.1	-1.1	-1.5	-1.4	1.4	-0.5	1.6	-0.2
Intermitt. access day 1 inactive lever presses	1.2	4.5	6.1	2.0	2.3	-2.3	-2.0	-2.0	2.0	-2.5	2.1	1.7
Intermitt. access day 15 inactive lever presses	0.8	1.7	4.9	1.0	1.3	-1.3	-0.9	-0.9	0.9	-1.7	1.0	2.2
Intermitt. access escalation Index	0.4	0.5	1.4	1.0	0.4	-0.4	-0.8	-0.7	0.7	0.1	0.5	-1.2
Intermittent access day 1 total infusions	0.3	0.6	3.4	0.7	0.3	-0.3	0.0	0.3	-0.3	-0.8	-0.4	1.8
Intermittent access day 15 total infusions	0.6	0.8	3.5	1.1	0.8	-0.8	-0.6	-0.4	0.4	-1.0	0.3	1.9
Intermittent access terminal intake (last 3 days)	1.2	1.6	3.2	1.3	1.2	-1.2	-1.1	-1.0	1.0	-1.3	1.0	1.8
Intermittent access total infusions	0.7	0.9	4.3	0.9	0.7	-0.7	-0.4	-0.2	0.2	-1.1	0.2	2.1
Intermittent access day 1 locomotion	0.5	0.7	2.2	1.3	0.6	-0.6	-0.5	-0.2	0.2	-0.9	-0.1	1.5
Intermittent access day 15 total locomotion	0.2	0.4	2.5	0.4	0.2	-0.2	0.0	0.2	-0.2	-0.6	-0.3	1.6
Intermittent access total locomotion	0.4	0.5	3.1	0.3	-0.0	0.0	0.3	0.5	-0.5	-0.4	-0.6	1.7
Intermittent access standard deviation	1.2	2.5	4.0	1.6	1.5	-1.5	-1.9	-1.8	1.8	-0.9	2.0	-0.3
Left kidney weight	2.9	13.5	16.7	4.0	3.8	-3.8	-4.1	-4.1	4.1	-3.5	3.6	1.2
Right kidney weight	3.0	13.4	16.4	3.9	3.9	-3.9	-4.0	-3.9	3.9	-3.6	3.6	1.6
Cocaine induced anxiety	0.5	0.7	1.4	-0.7	-0.9	0.9	0.7	0.6	-0.6	1.2	-0.6	-1.1
Post-drug Anxiety	0.2	0.2	0.9	-0.0	-0.3	0.3	0.0	-0.0	0.0	0.6	-0.1	-1.0
Baseline Anxiety	1.7	1.9	2.7	1.4	1.5	-1.5	-1.3	-1.3	1.3	-1.6	1.2	1.3
Tail length	4.6	18.2	21.6	3.9	4.6	-4.6	-4.4	-4.4	4.4	-4.6	4.5	2.5
Length with tail	6.5	28.2	34.4	5.0	5.8	-5.8	-5.3	-5.3	5.3	-5.9	5.4	3.7
Length without tail	1.5	4.9	5.9	2.0	2.4	-2.4	-2.2	-2.3	2.3	-2.4	2.3	1.4
Times rat made contact with spout	0.5	0.6	1.2	-0.7	-0.8	0.8	0.6	0.7	-0.7	1.1	-0.5	-0.9
Lifetime Intake	0.5	0.6	3.5	0.6	0.4	-0.4	-0.1	0.1	-0.1	-0.8	-0.0	1.9
Liver weight, left	0.2	0.3	0.3	0.6	0.5	-0.5	-0.5	-0.5	0.5	-0.5	0.4	0.3
Liver weight, right	0.1	0.1	0.5	0.0	0.4	-0.3	-0.1	-0.3	0.3	-0.5	0.3	0.7
Locomotor activity	0.6	0.9	1.6	-1.3	-1.1	1.1	1.0	0.7	-0.7	1.2	-0.7	-0.7
Locomotor testing distance	1.2	2.2	2.9	-1.6	-1.6	1.6	1.4	1.4	-1.4	1.7	-1.3	-1.2
Locomotor testing rearing	1.8	3.7	7.8	-1.6	-2.1	2.1	1.4	1.3	-1.3	2.6	-1.5	-2.8
Locomotion in novel chamber	1.0	1.3	3.0	-0.8	-1.2	1.2	0.9	1.0	-1.0	1.4	-1.0	-1.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.3	-0.6	0.1	-0.1	0.1	0.0	-0.0	-0.1	0.3	0.1
Fecal boli incidents, locomotor time 1	2.2	3.2	6.0	-1.4	-1.7	1.7	2.0	2.1	-2.1	1.0	-2.4	0.9
Change in fecal boli incidents, locomotor task	0.8	0.8	5.1	0.2	-0.4	0.4	-0.2	-0.2	0.2	1.1	0.1	-2.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.0	-0.1	0.1	0.1	0.1	-0.1	0.0	-0.2	0.1
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.6	0.2	-0.2	-0.5	-0.4	0.4	0.1	0.1	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.6	0.2	-0.2	-0.4	-0.2	0.2	-0.0	-0.1	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.5	0.2	-0.1	0.1	0.1	0.4	-0.4	-0.1	-0.6	0.7
Distance moved, locomotor task time 1	0.1	0.2	0.6	-0.1	0.2	-0.3	-0.2	-0.5	0.5	-0.0	0.8	-0.5
Vertical activity count, locomotor time 1	0.4	1.1	1.9	1.0	1.0	-1.0	-1.1	-1.2	1.2	-0.6	1.4	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.3	0.1	-0.1	-0.2	-0.4	0.4	0.0	0.2	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	1.0	-0.5	-0.4	0.4	0.5	0.7	-0.7	-0.0	-1.0	1.0
Total resting periods, locomotor time 2	0.2	0.4	0.9	-0.5	-0.4	0.4	0.5	0.7	-0.7	0.1	-1.0	0.9
Rest time, locomotor task time 2	0.4	0.6	0.7	0.8	0.8	-0.8	-0.8	-0.6	0.6	-0.9	0.7	0.7
Distance moved, locomotor task time 2	0.3	0.4	1.7	-0.6	-0.6	0.6	0.4	0.0	-0.0	0.8	-0.1	-1.3
Vertical activity count, locomotor time 2	0.3	0.3	2.3	0.2	-0.2	0.2	-0.2	-0.4	0.4	0.6	0.0	-1.5
Light reinforcement 1	0.1	0.4	0.9	-0.9	-0.6	0.6	0.7	0.4	-0.4	0.6	-0.4	-0.6
Light reinforcement 2	4.7	7.2	10.0	-3.0	-2.7	2.7	3.2	3.0	-3.0	2.1	-2.9	-0.0
Bone: marrow area	0.7	1.5	2.2	1.2	1.2	-1.2	-1.4	-1.5	1.5	-0.8	1.5	-0.5
Bone: maximum diameter	1.5	2.8	3.4	1.7	1.8	-1.8	-1.7	-1.6	1.6	-1.8	1.7	0.8
Bone: maximum force	2.7	4.7	5.9	2.4	2.2	-2.2	-2.4	-2.4	2.4	-1.8	2.4	0.6
Bone: maximum moment	3.6	6.3	7.7	2.8	2.6	-2.6	-2.8	-2.8	2.8	-2.2	2.7	0.6
Mean time between licks in bursts	0.2	0.4	0.5	0.7	0.7	-0.7	-0.6	-0.3	0.3	-0.7	0.6	0.7
Mean num. licks in bursts	0.4	0.6	1.1	0.7	0.5	-0.5	-0.9	-1.0	1.0	0.2	1.1	-0.7
Cd content in liver	1.5	1.6	4.7	-1.0	-1.3	1.3	0.8	0.9	-0.9	1.7	-0.7	-2.2
Co content in liver	0.7	0.8	1.2	-0.8	-0.9	0.9	1.0	1.1	-1.1	0.6	-1.1	0.6
Cu content in liver	2.3	2.7	6.5	1.2	1.7	-1.7	-1.3	-1.2	1.2	-2.1	1.2	2.5
Fe content in liver	0.8	1.0	1.6	-1.2	-0.9	0.9	1.1	1.1	-1.1	0.5	-1.3	0.9
K content in liver	1.3	1.2	2.3	0.7	1.2	-1.2	-0.9	-0.9	0.9	-1.4	1.0	1.5
Mg content in liver	0.9	0.9	4.3	0.3	0.8	-0.8	-0.4	-0.3	0.3	-1.2	0.4	2.1
Mn content in liver	0.9	1.0	1.2	1.1	1.0	-1.0	-1.1	-1.0	1.0	-0.9	0.9	0.6
Na content in liver	3.4	3.7	4.3	1.7	2.0	-2.0	-1.8	-1.9	1.9	-2.1	1.9	1.9
Rb content in liver	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	-0.1	0.1	-0.4	0.1	0.2
Se content in liver	2.2	2.5	3.2	-1.6	-1.7	1.7	1.7	1.7	-1.7	1.6	-1.8	-0.4
Sr content in liver	0.2	0.2	0.3	-0.4	-0.3	0.3	0.6	0.6	-0.6	0.2	-0.4	0.4
Zn content in liver	1.5	1.7	2.3	-1.5	-1.1	1.1	1.4	1.5	-1.5	0.6	-1.4	1.3
Bone: minimum diameter	4.4	8.1	11.2	3.2	2.7	-2.7	-3.3	-3.4	3.4	-1.7	3.3	-1.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.3	0.3	-0.3	-0.5	-0.4	0.4	-0.1	0.5	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.2	-0.2	0.2	0.3	0.3	-0.3	0.1	-0.3	0.2
Total zone transitions, hab. session 1	0.5	0.7	2.3	0.9	0.3	-0.3	-0.7	-1.0	1.0	0.3	0.7	-1.5
Total locomotion distance, hab. session 1	2.0	2.8	4.2	1.9	1.3	-1.3	-1.9	-2.0	2.0	-0.5	1.9	-1.5
Locomotion velocity, hab. session 1	0.8	1.2	1.7	1.2	0.7	-0.7	-1.2	-1.3	1.3	-0.1	1.3	-1.3
Time in familiar zone, hab. session 2	0.2	0.3	0.4	0.7	0.5	-0.6	-0.5	-0.5	0.5	-0.5	0.5	-0.1
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.9	-0.7	0.7	0.8	0.6	-0.6	0.7	-0.6	-0.2
Total zone transitions, hab. session 2	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.1	0.2	-0.0	-0.1
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.8	0.6	-0.6	-0.8	-0.7	0.7	-0.2	0.9	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.7	0.8	0.6	-0.6	-0.7	-0.6	0.6	-0.2	0.8	-0.6
Novel to familiar place preference ratio	0.8	0.9	1.9	0.9	0.6	-0.6	-1.0	-1.4	1.4	-0.1	1.1	-0.8
Novelty place preference	0.7	0.8	1.7	0.8	0.6	-0.6	-0.9	-1.3	1.3	-0.2	1.0	-0.7
Time in novel zone, NPP test	0.5	0.5	1.2	0.6	0.4	-0.4	-0.7	-1.1	1.1	-0.0	0.8	-0.8
Total zone transitions, NPP test	0.1	0.2	0.4	-0.2	-0.5	0.5	0.5	0.5	-0.5	0.4	-0.6	-0.2
Total locomotion distance, NPP test	1.1	1.5	2.0	1.4	1.1	-1.1	-1.4	-1.4	1.4	-0.5	1.4	-0.9
Locomotion velocity, NPP test	1.4	2.0	2.8	1.7	1.3	-1.3	-1.6	-1.7	1.7	-0.8	1.6	-0.8
Intraocular pressure	0.2	0.2	1.3	-0.3	-0.1	0.1	0.3	0.4	-0.4	-0.2	-0.5	1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.2	-0.4	0.4	0.3	0.3	-0.3	0.3	-0.6	0.0
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2	-0.2	0.2	-0.0	0.0	-0.2
Parametrial fat weight	0.1	0.2	0.4	-0.6	-0.3	0.3	0.4	0.4	-0.4	0.1	-0.4	0.5
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	-0.8	0.8	0.8	0.6	-0.6	0.8	-0.6	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	-0.2	-0.3	0.3	0.4	0.6	-0.6	0.2	-0.6	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	0.1	-0.1	-0.2	-0.1	-0.0
Pavlov. Cond. index score	0.0	0.1	0.1	0.4	0.2	-0.3	-0.2	-0.0	0.0	-0.3	0.0	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	0.4	-0.4	-0.4	-0.2	0.2	-0.4	0.2	0.3
Pavlov. Cond. lever contacts	0.9	1.1	1.5	1.1	1.2	-1.2	-1.1	-0.9	0.9	-1.2	0.9	0.9
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.1	-0.3	0.3	-0.1	0.4	0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.3	-0.5	0.5	0.3	0.2	-0.2	0.6	-0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.5	0.4	-0.4	-0.3	-0.1	0.1	-0.5	0.1	0.4
Pavlov. Cond. response bias	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3	-0.1	0.1	-0.4	0.0	0.4
Pavlov. Cond. lever latency	3.4	4.6	5.8	-2.4	-2.3	2.3	2.3	2.3	-2.3	2.1	-2.1	-0.7
Pavlov. Cond. magazine entry latency	2.8	3.4	5.3	1.7	2.0	-2.0	-1.6	-1.6	1.6	-2.3	1.5	2.3
Pavlov. Cond. change in total contacts	4.6	7.4	9.1	3.0	2.8	-2.8	-3.0	-3.0	3.0	-2.5	2.8	0.7
Pavlov. Cond. index score	3.4	4.6	5.4	2.3	2.3	-2.3	-2.2	-2.2	2.2	-2.3	1.9	1.5
Pavlov. Cond. latency score	3.1	4.2	5.3	2.1	2.2	-2.2	-2.0	-2.0	2.0	-2.3	1.8	1.6
Pavlov. Cond. lever contacts	3.6	5.0	6.2	2.5	2.3	-2.3	-2.4	-2.4	2.4	-2.2	2.2	0.7
Pavlov. Cond. magazine entry number	1.5	1.8	2.9	-1.3	-1.5	1.5	1.3	1.2	-1.2	1.7	-1.0	-1.3
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.9	-1.4	-0.8	0.8	1.2	1.1	-1.1	0.5	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.9	5.8	2.3	2.3	-2.3	-2.2	-2.2	2.2	-2.4	2.0	1.6
Pavlov. Cond. response bias	4.5	6.1	7.6	2.8	2.6	-2.6	-2.6	-2.6	2.6	-2.5	2.4	1.1
Time in closed arm before self-admin	0.1	0.1	0.3	-0.4	-0.0	0.0	0.0	-0.0	0.0	0.3	0.4	-0.6
Time in closed arm after self-admin	0.2	0.2	1.1	-0.0	0.3	-0.3	0.1	0.1	-0.1	-0.5	0.1	1.1
Time in open arm before self-admin	0.9	1.0	1.6	1.0	1.0	-1.0	-0.9	-1.0	1.0	-1.3	0.7	1.2
Time in open arm after self-admin	1.4	1.5	2.3	1.5	1.2	-1.2	-1.5	-1.5	1.5	-0.9	1.1	-0.2
Bone: periosteal estimation	1.7	3.6	5.0	2.0	1.9	-1.9	-2.2	-2.2	2.2	-1.4	2.2	-0.2
Bone: periosteal perimeter	1.5	2.6	3.4	1.7	1.6	-1.6	-1.8	-1.9	1.9	-1.2	1.8	-0.3
Bone: post-yield work	0.7	1.0	1.6	1.3	0.8	-0.8	-1.1	-1.2	1.2	-0.5	1.0	-0.9
Progressive ratio test 1 active lever presses	1.3	1.6	4.0	1.7	1.2	-1.2	-1.0	-0.7	0.7	-1.6	0.6	2.0
Progressive ratio test 1 breakpoint	1.6	1.9	4.0	1.8	1.4	-1.4	-1.1	-0.9	0.9	-1.7	0.8	2.0
Progressive ratio test 1 inactive lever presses	1.2	1.7	3.7	1.6	1.3	-1.3	-1.1	-0.8	0.8	-1.6	0.8	1.9
Progressive ratio test 2 active lever presses	0.5	0.6	3.6	0.5	0.3	-0.3	0.1	0.3	-0.3	-0.8	-0.4	1.9
Progressive ratio test 2 breakpoint	0.5	0.5	3.3	0.5	0.2	-0.2	0.1	0.3	-0.3	-0.8	-0.4	1.8
Progressive ratio test 2 inactive lever presses	1.2	2.0	7.5	1.3	1.3	-1.3	-0.9	-0.8	0.8	-1.8	0.6	2.7
Incentive Sensitization - Responses	0.3	0.4	0.7	-0.8	-0.5	0.5	0.8	0.7	-0.7	0.2	-0.8	0.6
Incentive Sensitization - Breakpoint	0.4	0.5	0.8	-0.9	-0.6	0.6	0.9	0.8	-0.8	0.3	-0.8	0.5
Sum of active levers in priming session hrs 5-6	0.9	0.9	5.5	-0.2	-0.6	0.6	0.0	0.0	-0.0	1.3	0.1	-2.3
Progressive ratio	1.0	1.5	2.2	-1.1	-1.3	1.3	1.1	1.2	-1.2	1.4	-0.9	-1.5
Food seeking constrained by brief footshock	1.8	2.2	3.0	1.7	1.5	-1.5	-1.7	-1.7	1.7	-1.0	1.7	-0.5
Seeking ratio, punishment vs. effort	1.8	2.5	3.4	1.5	1.7	-1.7	-1.5	-1.6	1.6	-1.8	1.4	1.4
Retroperitoneal fat weight	0.3	1.3	2.4	-1.5	-1.1	1.1	1.3	1.2	-1.2	0.8	-1.3	0.5
Reaction time number correct	0.1	0.1	0.7	0.4	0.3	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.8
Reaction time mean minus median	0.2	0.4	0.7	0.3	0.7	-0.7	-0.5	-0.6	0.6	-0.8	0.5	0.8
Reaction time mean minus median AUC	0.3	0.7	1.6	0.6	1.0	-1.0	-0.7	-0.7	0.7	-1.3	0.5	0.9
Reaction time num false alarms	0.9	1.2	1.6	-0.8	-1.2	1.2	1.0	1.3	-1.3	1.2	-1.3	-0.7
Reaction time num false alarms AUC	1.2	1.9	2.4	-1.0	-1.4	1.4	1.3	1.6	-1.6	1.4	-1.5	-1.0
Reaction time trials correct on left	0.1	0.1	0.7	0.4	0.3	-0.3	-0.3	-0.3	0.3	-0.3	0.3	-0.8
Reaction time trials on left	0.1	0.1	0.6	0.3	0.3	-0.3	-0.2	-0.3	0.3	-0.3	0.2	-0.8
Reaction time mean	0.1	0.2	1.7	-0.2	0.1	-0.1	0.2	0.3	-0.3	-0.4	-0.2	1.3
Reaction time mean AUC	0.3	0.5	3.0	-0.3	0.0	-0.0	0.3	0.5	-0.5	-0.5	-0.4	1.7
Median of all reaction times	0.3	0.4	1.3	-0.5	-0.3	0.3	0.6	0.7	-0.7	0.0	-0.6	1.1
Reaction time omissions	0.2	0.3	0.7	-0.5	-0.4	0.5	0.5	0.4	-0.4	0.3	-0.6	0.8
Reaction time false alarm rate	1.1	1.5	2.2	-1.0	-1.3	1.3	1.2	1.5	-1.5	1.2	-1.4	-0.3
Reaction time premature initiation rate	0.0	0.0	0.1	0.1	-0.0	0.0	-0.1	-0.0	0.0	0.2	-0.0	-0.0
Reaction time premature initiations	0.0	0.0	0.2	0.2	0.1	-0.1	-0.2	-0.1	0.1	0.1	0.1	-0.5
Std. dev. reaction times	0.3	0.6	3.1	0.2	0.7	-0.7	-0.5	-0.4	0.4	-1.0	0.4	1.7
Reaction time trials completed	0.1	0.1	0.6	0.3	0.3	-0.3	-0.2	-0.3	0.3	-0.3	0.2	-0.8
Reaction time trials AUC	0.1	0.1	0.7	0.3	0.2	-0.2	-0.1	-0.1	0.1	-0.2	0.1	-0.8
Run reversals in cocaine runway, females	0.5	0.4	3.0	-0.3	0.1	-0.0	0.4	0.3	-0.3	-0.6	-0.5	1.7
Run reversals in cocaine runway, males	0.8	0.8	1.6	-1.3	-0.9	0.9	0.9	0.9	-0.9	1.0	-0.6	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.3	-0.1	0.1	0.3	0.1	-0.1	0.1	-0.1	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.4	1.1	-0.8	-0.5	0.5	0.6	0.4	-0.4	0.5	-0.3	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.5	0.2	-0.3	-0.2	-0.2	0.2	-0.3	-0.0	0.5
Std. dev. time between licks in bursts	0.3	0.4	0.8	0.9	0.6	-0.6	-0.8	-0.7	0.7	-0.3	0.7	-0.4
Total sessions with >9 infusions	0.2	0.3	0.5	0.3	-0.5	0.5	0.3	0.5	-0.5	0.6	-0.5	-0.7
Short access day 1 total inactive lever presses	0.8	1.0	1.6	0.9	1.1	-1.1	-0.8	-0.8	0.8	-1.3	1.0	1.2
Short access day 10 total inactive lever presses	1.0	2.5	3.5	1.4	1.8	-1.8	-1.5	-1.5	1.5	-1.9	1.6	1.2
Short access day 1 total infusions	0.8	1.0	1.7	1.3	1.1	-1.1	-1.0	-1.0	1.0	-1.1	0.8	0.4
Short access day 10 total infusions	0.1	0.1	0.6	0.2	0.1	-0.1	-0.0	0.1	-0.1	-0.3	0.0	0.8
Short access total infusions	0.1	0.1	0.6	0.6	0.1	-0.1	-0.0	0.2	-0.2	-0.2	-0.3	0.8
Short access day 1 locomotion	1.0	1.2	1.8	-0.7	-1.2	1.2	1.0	1.1	-1.1	1.2	-1.3	-0.8
Short access day 10 total locomotion	0.5	0.9	2.4	1.5	0.9	-0.9	-1.1	-0.9	0.9	-0.7	0.9	0.1
Short access total locomotion	0.1	0.1	0.8	0.9	-0.1	0.1	-0.1	0.1	-0.1	0.3	-0.3	-0.3
One hour access (0.3 mA shock)	0.6	0.7	1.2	1.1	0.8	-0.8	-0.7	-0.6	0.6	-0.9	0.7	1.1
Compulsive drug intake	1.8	2.2	4.0	1.4	1.1	-1.1	-1.6	-1.7	1.7	-0.3	1.7	-2.0
One hour access (shock baseline)	0.3	0.5	4.0	0.3	0.2	-0.2	0.1	0.3	-0.3	-0.6	-0.2	2.0
Social response proportion	4.4	5.0	6.3	2.2	2.3	-2.3	-2.3	-2.4	2.4	-2.1	2.5	1.1
Social responses	0.2	0.3	1.4	0.2	0.4	-0.4	-0.2	-0.4	0.4	-0.8	0.3	1.2
Social time	0.2	0.3	0.9	0.5	0.3	-0.3	-0.6	-0.7	0.7	-0.1	0.5	-1.0
Soleus weight	1.0	3.1	5.4	-1.3	-1.9	1.9	1.4	1.5	-1.5	2.3	-1.7	-2.0
Bone: stiffness	1.1	1.8	2.8	1.7	1.3	-1.3	-1.6	-1.5	1.5	-0.8	1.6	0.2
Tibialis anterior weight	0.2	0.8	5.4	0.3	-0.6	0.6	0.0	0.1	-0.1	1.1	-0.4	-2.3
Time to tail flick, vehicle, before self-admin	0.4	0.4	2.7	0.1	0.5	-0.5	-0.2	-0.2	0.2	-0.8	0.3	1.6
Time to tail flick, vehicle, after self-admin	0.9	1.2	4.6	0.8	1.0	-1.0	-0.7	-0.7	0.7	-1.4	0.4	2.1
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.7	-0.5	0.5	0.6	0.4	-0.4	0.4	-0.5	-0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.6	-0.0	-0.2	0.2	0.2	0.4	-0.4	-0.1	-0.4	0.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.7	0.6	-0.6	-0.6	-0.5	0.5	-0.7	0.4	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	1.2	0.3	0.2	-0.2	-0.2	-0.1	0.1	-0.4	0.1	1.1
Tibia length	2.2	6.0	7.5	2.2	2.7	-2.7	-2.4	-2.4	2.4	-2.7	2.6	1.7
Ambulatory time before self-admin	1.3	1.9	2.5	1.6	1.4	-1.4	-1.5	-1.6	1.6	-1.2	1.4	0.4
Ambulatory time after self-admin	2.5	3.0	3.8	1.9	1.7	-1.7	-1.9	-1.9	1.9	-1.6	1.6	0.8
Bone: tissue strength	4.0	4.0	5.1	2.3	2.1	-2.1	-2.2	-2.2	2.2	-1.8	2.1	0.2
Total heroin consumption	1.2	1.4	5.0	1.4	0.5	-0.5	-1.2	-1.2	1.2	0.3	1.0	-2.2
Bone: trabecular number	0.1	0.2	0.4	0.3	0.5	-0.5	-0.3	-0.4	0.4	-0.6	0.3	0.1
Bone: trabecular spacing	1.3	1.7	2.5	1.6	1.2	-1.2	-1.5	-1.5	1.5	-0.8	1.4	0.4
Bone: trabecular thickness	0.1	0.1	0.5	-0.4	0.0	-0.0	0.3	0.4	-0.4	-0.4	-0.3	0.7
Bone: trabecular tissue density	2.5	3.6	4.3	-2.1	-2.0	2.0	2.0	1.9	-1.9	2.0	-1.8	-1.2
Water consumed over 24 hours	0.9	1.2	1.6	1.1	1.2	-1.2	-1.1	-1.0	1.0	-1.3	1.0	1.0
Number of responses in last shaping day	0.5	0.5	0.9	0.4	0.8	-0.8	-0.7	-0.8	0.8	-0.8	1.0	0.0