Fbln7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Fbln7	0.19	0.1	8.9e-16	0.16	0.16	0.16	0.17	3.9e-15	1.2e-14	7.3e-15	1.8e-15
2	NAcc	gene expression	Fbln7	0.1	0.06	4.7e-11	0.1	0.09	0.09	0.1	1.1e-11	1.8e-10	1.1e-10	3.7e-11
3	pVTA	gene expression	Fbln7	0.13	0.09	2.3e-04	0.1	0.06	0.11	0.01	3.8e-05	1.1e-03	1.9e-05	8.8e-02
4	IL	gene expression	Fbln7	0.32	0.17	4.8e-04	0.11	0.08	0.08	0.1	1.1e-03	6.1e-03	6.2e-03	2.1e-03
5	BLA	gene expression	Fbln7	0.22	0.14	1.8e-07	0.11	0.13	0.15	0.14	1.2e-06	3.0e-07	2.7e-08	1.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.1	3.4	4.4	-2.1	2.1	1.7	1.6	1.8
Area under the delay curve	0.5	0.5	0.7	0.7	-0.6	-0.5	-0.8	-0.7
BMI with tail	0.9	2.8	4.8	-1.7	1.2	2.2	1.6	1.6
BMI without tail	3.3	6.8	10.3	-2.6	2.0	3.2	2.7	2.4
Body weight	5.0	20.8	27.3	-4.8	3.9	5.2	4.5	4.2
Weight adjusted by age	5.4	6.1	7.7	-2.7	2.8	2.1	2.2	2.5
Bone surface	1.3	2.3	3.2	-1.6	1.8	1.3	1.3	1.5
Bone volume	1.5	2.5	3.7	-1.8	1.9	1.4	1.2	1.5
Breakpoint value in progressive ratio session	0.7	0.8	1.4	-0.7	0.4	1.1	1.2	0.7
Number of licking bursts	0.3	0.4	0.7	-0.6	0.3	0.5	0.8	0.7
Context. condit. distance diff. score	2.0	2.4	4.4	-1.7	2.1	0.8	1.2	1.6
Locomotion velocity, session 1	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.5	-0.2
Locomotion distance, session 1	0.8	1.0	2.0	-1.2	1.4	0.7	0.6	0.9
Locomotion velocity, session 2	0.3	0.3	0.6	0.4	-0.6	-0.1	-0.5	-0.8
Locomotion distance, session 2	2.2	3.1	4.5	-2.1	2.1	1.5	1.1	1.8
Locomotion velocity, session 3	0.6	0.7	1.7	-0.4	-0.1	1.3	1.3	-0.0
Locomotion distance, session 3	5.7	6.3	10.3	-2.3	1.5	3.2	3.1	1.9
Stereotopy head waving bouts, day 3	1.4	1.6	3.4	1.0	-0.2	-1.8	-1.8	-0.9
Stereotopy head waving duration, day 3	1.5	1.8	2.8	1.3	-0.8	-1.7	-1.5	-1.2
Locomotion velocity, session 7	1.7	1.9	2.5	-1.3	1.3	1.5	1.6	1.1
Locomotion distance, session 7	4.7	5.9	8.1	-2.7	2.8	1.8	2.1	2.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	-0.5	0.3	0.1	-0.5
Stereotopy head waving duration, day 7	0.6	0.7	1.4	0.9	-1.2	-0.2	-0.5	-1.0
Locomotion velocity, session 8	0.6	0.7	1.0	-0.9	1.0	0.8	0.6	0.8
Locomotion distance, session 8	6.2	9.1	13.8	-3.4	3.7	2.4	2.3	3.1
Degree of sensitization distance	0.7	0.7	1.5	-0.1	0.9	-1.2	-1.0	0.4
Degree of sensitization stereotypy	0.5	0.6	1.7	-0.5	-0.2	1.3	1.0	0.1
Conditioned locomotion	2.0	2.4	3.6	-1.7	1.9	1.2	1.2	1.7
Cocaine response after cond. corrected	0.1	0.1	0.3	0.2	-0.0	-0.5	-0.5	-0.2
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.4	-0.3	-0.6	-0.8	-0.5
Cocaine response before conditioning	0.3	0.3	0.4	0.5	-0.6	-0.4	-0.6	-0.6
Saline control response	3.7	4.9	5.7	-2.3	2.1	2.4	2.4	1.9
Bone: connectivity density	1.1	1.7	2.4	-1.5	1.5	1.1	1.1	1.2
Bone: cortical apparent density	0.0	0.1	0.1	-0.0	-0.2	0.3	0.1	0.3
Bone: cortical area	2.3	3.5	4.5	-2.1	1.8	2.1	1.7	1.6
Bone: cortical porosity	1.8	1.9	4.0	1.5	-2.0	-0.2	-0.6	-1.7
Bone: cortical porosity	0.9	1.0	2.4	0.9	-1.6	0.4	0.1	-1.2
Bone: cortical thickness	0.5	0.7	1.2	-1.0	0.7	1.1	0.5	0.9
Bone: cortical thickness	0.1	0.1	0.3	-0.2	0.0	0.5	0.1	0.0
Bone: cortical tissue density	0.0	0.0	0.1	0.1	-0.3	0.1	-0.0	0.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.6	-0.7	0.4	0.7	0.6	0.8
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.4	-1.1	1.0	0.8	0.9	1.2
Condit. Reinf. active responses	0.1	0.1	0.3	-0.5	0.2	0.5	0.1	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.0	0.1	-0.2	-0.7	-0.1
Incentive salience index mean	0.3	0.4	0.6	-0.7	0.6	0.4	0.3	0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	0.5	0.3	-0.1	0.3
Condit. Reinf. active minus inactive responses	3.4	4.2	5.1	-2.3	2.1	1.9	2.0	1.8
Condit. Reinf. active-inactive response ratio	4.2	4.5	5.3	-2.2	2.1	2.0	2.3	1.9
Condit. Reinf. active responses	3.8	5.3	6.4	-2.5	2.3	2.3	2.4	2.0
Condit. Reinf. inactive responses	0.4	0.5	0.7	-0.9	0.8	0.7	0.5	0.6
Condit. Reinf. lever presses	1.2	1.7	2.3	-1.4	1.0	1.5	1.5	1.0
Condit. Reinf. lever reinforcers received	3.3	4.6	5.7	-2.4	2.2	2.1	2.1	1.8
Conditioned reinforcement - actives	0.8	0.8	1.3	-0.9	0.8	0.9	0.7	1.1
Conditioned reinforcement - inactives	3.3	3.7	7.0	-2.3	2.6	1.3	0.6	2.1
Conditioned locomotion	0.4	0.5	0.8	-0.7	0.7	0.7	0.6	0.9
Patch foraging indifference point 0 sec	0.2	0.2	0.7	-0.7	0.9	-0.0	0.0	0.2
Patch foraging indifference point AUC	0.4	0.5	0.7	-0.7	0.7	0.6	0.6	0.9
Delay disc. indifference point, 0s delay	6.3	6.9	9.7	2.5	-2.5	-2.3	-3.1	-2.6
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.6	-0.5	-0.8	-0.9	-0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	0.5	-0.3	-0.2	-0.7	-0.6
Delay disc. indifference point, 24s delay	1.5	1.5	2.1	1.3	-1.0	-1.1	-1.1	-1.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.4	-0.5	0.1	-0.6	-0.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.6	-0.6	-0.3	-0.3	-0.4
Indifference point function ln k	0.3	0.4	0.8	-0.8	0.9	0.5	0.3	0.3
Indifference point function log k	0.3	0.4	0.8	-0.8	0.9	0.5	0.3	0.3
Patch foraging total patch changes 0 sec	0.2	0.3	0.9	-0.7	1.0	-0.0	-0.0	0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.2	0.1	-0.2	0.0	0.1	-0.4
Patch foraging total patch changes 18 sec	0.3	0.4	1.2	0.3	0.1	-1.1	-0.8	-0.5
Patch foraging total patch changes 24 sec	0.5	0.7	1.7	0.0	0.7	-1.3	-1.1	0.1
Patch foraging total patch changes 6 sec	0.7	1.1	2.0	-1.2	1.4	0.5	0.6	1.1
Patch foraging time to switch 0 sec	3.6	5.5	8.5	2.7	-2.9	-1.8	-1.4	-2.6
Patch foraging water rate 0 sec	5.2	8.4	11.6	-3.3	3.4	2.3	2.1	3.1
Patch foraging water rate 12 sec	1.1	1.7	2.9	-1.6	1.7	1.0	0.6	1.3
Patch foraging water rate 18 sec	0.4	0.5	0.7	-0.8	0.5	0.8	0.6	0.7
Patch foraging water rate 24 sec	0.7	0.9	1.3	-1.1	0.8	1.1	1.0	0.8
Patch foraging water rate 6 sec	1.9	2.8	4.0	-2.0	1.7	1.7	1.3	1.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.5	0.3	-0.1	-0.4	-0.7	-0.1
Distance traveled before self-admin	5.6	5.9	7.5	-2.6	2.7	2.1	2.3	2.4
Distance traveled after self-admin	3.0	3.3	3.6	-1.8	1.8	1.9	1.9	1.7
Extensor digitorum longus weight	0.1	0.4	0.8	-0.6	0.3	0.9	0.8	0.5
Bone: elastic displacement	0.3	0.4	1.0	0.6	-1.0	0.3	0.4	-0.6
Bone: elastic work	0.1	0.1	0.2	0.2	-0.4	0.3	0.4	-0.2
Bone: endosteal estimation	0.9	1.9	2.9	-1.4	1.4	1.4	1.7	0.9
Bone: endosteal perimeter	2.1	4.3	5.1	-2.2	2.1	2.0	2.3	1.7
Epididymis fat weight	0.6	1.5	2.1	-1.2	1.0	1.3	1.4	1.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.6	-0.7	-0.5	-0.7	-0.7
Delta time in open arm before/after self-admin	1.5	1.5	1.9	-1.3	1.4	1.1	1.1	1.1
Diff in mean of infusions in LGA sessions	1.1	1.2	1.6	1.3	-1.3	-1.1	-0.8	-1.1
Delay discount exponential model param	0.4	0.4	0.6	-0.8	0.6	0.5	0.7	0.7
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.4	0.5	-0.2	-0.6	-0.5	-0.5
Bone: final force	3.2	5.2	6.1	-2.5	2.2	2.4	2.2	2.1
Bone: final moment	2.5	4.1	4.9	-2.2	1.9	2.2	2.0	1.8
Food consumed during 24 hour testing period	0.3	0.3	0.9	0.5	-0.2	-0.9	-0.6	-0.4
Glucose	0.3	0.5	0.7	-0.7	0.8	0.7	0.8	0.5
Heart weight	6.1	8.7	11.2	-3.3	3.4	2.5	2.0	3.2
Delay discount hyperbolic model param	0.4	0.4	0.5	-0.7	0.6	0.4	0.7	0.7
Intermittent access intake day 1-15 change	3.0	3.0	3.7	-1.9	1.8	1.8	1.1	1.8
Intermittent access intake escalation	2.4	2.4	2.9	-1.7	1.6	1.6	1.0	1.7
Intermittent access intake escalation 2	0.7	0.7	0.9	-0.9	0.9	0.8	0.4	0.9
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.5	-1.5	1.6	1.1	0.7	1.3
Intermitt. access day 15 inactive lever presses	1.2	1.3	3.3	-1.3	1.8	0.3	0.2	1.2
Intermitt. access escalation Index	0.9	0.8	1.5	1.0	-1.2	-0.4	-0.6	-1.1
Intermittent access day 1 total infusions	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.2
Intermittent access day 15 total infusions	1.1	1.3	1.9	-1.2	1.2	1.1	0.5	1.4
Intermittent access terminal intake (last 3 days)	1.0	1.1	2.0	-1.2	1.3	0.7	0.2	1.4
Intermittent access total infusions	0.3	0.4	0.7	-0.6	0.8	0.2	-0.2	0.8
Intermittent access day 1 locomotion	0.4	0.5	0.8	-0.6	0.6	0.4	0.8	0.9
Intermittent access day 15 total locomotion	1.6	1.8	3.1	-1.4	1.8	0.6	0.5	1.7
Intermittent access total locomotion	1.4	1.5	2.5	-1.3	1.5	0.8	0.8	1.6
Intermittent access standard deviation	0.6	0.6	1.2	-0.8	0.7	0.7	0.3	1.1
Left kidney weight	0.9	2.6	4.6	-1.9	2.2	1.2	1.0	1.5
Right kidney weight	0.7	1.9	3.5	-1.8	1.9	1.1	0.6	1.2
Cocaine induced anxiety	3.5	4.1	9.8	2.1	-1.3	-3.1	-1.3	-1.6
Post-drug Anxiety	1.5	1.7	4.0	1.4	-1.0	-2.0	-0.7	-1.0
Baseline Anxiety	0.7	0.8	1.8	-0.9	0.6	1.3	0.4	0.8
Tail length	3.9	11.9	17.0	-3.3	2.7	4.1	4.0	2.8
Length with tail	3.5	12.8	14.8	-3.8	3.5	3.8	3.5	3.2
Length without tail	0.8	1.8	2.5	-1.6	1.5	1.2	1.0	1.3
Times rat made contact with spout	0.0	0.0	0.1	0.2	-0.1	-0.4	0.0	0.1
Lifetime Intake	0.4	0.5	1.1	-0.7	0.8	0.4	0.2	1.0
Liver weight, left	0.4	0.7	1.6	-0.9	1.3	-0.0	-0.0	1.0
Liver weight, right	0.0	0.1	0.2	-0.0	-0.1	-0.4	-0.2	0.1
Locomotor activity	0.6	0.9	1.7	-0.8	0.7	1.3	1.3	0.4
Locomotor testing distance	0.1	0.1	0.2	-0.2	0.4	0.2	0.4	-0.1
Locomotor testing rearing	0.7	1.1	2.1	-1.1	1.4	0.8	0.9	0.8
Locomotion in novel chamber	0.6	0.7	1.7	-0.5	0.5	0.8	1.3	0.8
Locomotion in novel chamber post-restriction	1.0	1.2	2.9	-0.7	0.5	1.4	1.7	0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.3	-0.5	0.1	0.3	-0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	-0.3	-0.1	0.8	0.3	0.4
Bouts of movement, locomotor time 1	5.8	6.3	8.7	2.4	-2.6	-2.2	-3.0	-2.4
Total resting periods, locomotor time 1	5.3	5.8	7.7	2.3	-2.6	-2.0	-2.8	-2.3
Rest time, locomotor task time 1	0.6	0.6	0.9	0.9	-1.0	-0.6	-0.7	-0.8
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	0.2	0.1	0.1	0.3
Vertical activity count, locomotor time 1	0.3	0.3	0.4	-0.5	0.6	0.4	0.6	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.2	0.3	0.5	-0.0	0.4
Bouts of movement, locomotor time 2	0.8	0.9	1.8	1.0	-1.4	-0.5	-0.8	-0.8
Total resting periods, locomotor time 2	0.7	0.8	2.0	0.9	-1.4	-0.3	-0.7	-0.8
Rest time, locomotor task time 2	0.4	0.5	1.1	0.7	-1.1	-0.3	-0.4	-0.6
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.1	0.4	-0.5	-0.6	-0.0
Vertical activity count, locomotor time 2	0.2	0.2	0.7	-0.3	0.8	-0.1	-0.1	0.3
Light reinforcement 1	0.8	1.4	2.0	-1.3	1.1	1.2	1.4	0.9
Light reinforcement 2	0.5	0.7	1.0	-0.8	0.7	0.7	0.8	1.0
Bone: marrow area	0.9	1.9	2.8	-1.4	1.5	1.3	1.7	0.9
Bone: maximum diameter	3.6	6.7	8.0	-2.8	2.6	2.7	2.5	2.2
Bone: maximum force	0.6	1.0	1.3	-1.1	1.1	0.9	0.9	0.8
Bone: maximum moment	0.3	0.4	0.6	-0.8	0.8	0.6	0.6	0.5
Mean time between licks in bursts	0.4	0.6	1.2	0.9	-0.9	-0.1	-0.2	-1.1
Mean num. licks in bursts	0.4	0.5	0.9	0.6	-0.2	-0.8	-0.9	-0.5
Cd content in liver	0.4	0.4	0.7	-0.7	0.7	0.5	0.5	0.8
Co content in liver	0.8	0.9	1.3	-1.0	0.9	1.2	0.9	0.8
Cu content in liver	1.1	1.3	2.4	-1.0	0.8	1.6	1.3	0.8
Fe content in liver	0.2	0.3	0.5	-0.6	0.7	0.4	0.6	0.3
K content in liver	0.1	0.1	0.2	0.1	-0.1	0.5	-0.0	-0.3
Mg content in liver	0.6	0.7	1.4	-0.8	0.7	1.2	0.7	0.5
Mn content in liver	1.0	1.1	2.3	-1.0	0.7	1.5	1.2	0.7
Na content in liver	0.2	0.2	0.4	0.3	-0.2	-0.4	-0.5	-0.7
Rb content in liver	2.7	3.4	3.5	-1.8	1.9	1.9	1.9	1.7
Se content in liver	2.1	2.6	3.4	-1.8	1.8	1.4	1.5	1.4
Sr content in liver	0.8	0.8	1.1	-0.8	0.9	1.1	0.8	0.7
Zn content in liver	0.1	0.1	0.3	-0.4	0.6	0.1	-0.4	0.3
Bone: minimum diameter	0.8	1.5	2.4	-1.3	1.1	1.6	1.1	0.9
Time in familiar zone, hab. session 1	0.8	0.8	1.1	1.1	-1.1	-0.6	-0.7	-0.9
Time in novel zone, hab. session 1	1.1	1.1	1.9	-1.2	1.4	0.2	0.5	1.3
Total zone transitions, hab. session 1	0.6	0.9	1.6	-1.2	1.3	0.8	0.4	0.8
Total locomotion distance, hab. session 1	1.0	1.4	3.4	-1.5	1.8	0.7	0.2	0.9
Locomotion velocity, hab. session 1	1.0	1.4	3.3	-1.5	1.8	0.7	0.2	0.9
Time in familiar zone, hab. session 2	0.9	0.9	1.4	1.1	-0.8	-1.2	-1.0	-0.7
Time in novel zone, hab. session 2	1.0	1.0	1.4	-1.1	0.8	1.2	1.0	0.8
Total zone transitions, hab. session 2	2.4	3.1	4.0	-2.0	1.6	2.0	1.6	1.5
Total locomotion distance, hab. session 2	2.2	2.9	6.0	-2.1	2.4	0.9	0.4	1.8
Locomotion velocity, hab. session 2	1.5	2.0	4.8	-1.7	2.2	0.5	-0.1	1.5
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.4	0.2
Novelty place preference	0.1	0.1	0.4	0.2	0.1	-0.6	-0.5	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.0	0.3	-0.5	-0.4	0.1
Total zone transitions, NPP test	0.7	1.0	1.3	-1.1	1.0	0.9	0.8	1.0
Total locomotion distance, NPP test	2.3	3.2	6.4	-2.1	2.5	0.9	0.6	1.9
Locomotion velocity, NPP test	1.5	2.1	4.7	-1.7	2.2	0.6	0.3	1.6
Intraocular pressure	0.1	0.1	0.4	0.0	-0.2	0.5	0.6	-0.1
Delta distance traveled before/after self-admin	0.1	0.2	0.4	0.5	-0.6	-0.0	-0.1	-0.4
Delta ambulatory time before/after self-admin	2.9	3.1	4.1	1.9	-2.0	-1.4	-1.6	-1.8
Parametrial fat weight	0.4	0.7	2.5	0.6	-0.6	-0.6	-1.6	-0.3
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.2	-0.5	0.5	0.8	-0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	-1.0	1.2	0.5	0.1	1.1
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	-0.7	0.9	0.2	0.1	0.8
Pavlov. Cond. index score	0.2	0.2	0.4	-0.4	0.6	-0.1	-0.4	0.6
Pavlov. Cond. latency score	0.3	0.3	0.5	-0.4	0.7	-0.4	-0.7	0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.6	-0.5	0.8	-0.1	-0.4	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.8	-0.6	-0.9	-0.6	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.4	0.4	0.7	0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.3	0.5	-0.1	-0.3	0.5
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.9	0.9	0.7	0.4	0.8
Pavlov. Cond. lever latency	3.0	4.1	5.1	2.3	-1.8	-2.2	-2.1	-1.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.3	0.3	0.3	0.4	0.2
Pavlov. Cond. change in total contacts	1.6	2.2	3.3	-1.5	1.1	1.8	1.8	1.1
Pavlov. Cond. index score	2.0	2.6	3.8	-1.7	1.3	1.9	1.9	1.2
Pavlov. Cond. latency score	1.5	1.8	2.5	-1.4	1.1	1.6	1.5	1.0
Pavlov. Cond. lever contacts	2.9	3.9	4.9	-2.2	1.8	2.2	2.0	1.6
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	0.8	-0.6	-1.1	-1.1	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.0	0.2	-0.6	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	2.9	-1.4	1.1	1.7	1.6	1.0
Pavlov. Cond. response bias	3.1	4.3	5.4	-2.2	1.8	2.3	2.2	1.7
Time in closed arm before self-admin	0.7	0.8	1.2	0.9	-0.9	-0.8	-0.6	-1.1
Time in closed arm after self-admin	2.2	2.2	3.3	1.6	-1.8	-1.0	-1.1	-1.7
Time in open arm before self-admin	0.1	0.1	0.1	0.4	-0.4	-0.2	-0.2	-0.2
Time in open arm after self-admin	1.0	1.0	2.1	-1.2	1.5	0.6	0.7	0.9
Bone: periosteal estimation	2.0	4.1	5.1	-2.1	2.0	2.3	2.2	1.5
Bone: periosteal perimeter	2.3	3.9	4.5	-2.1	2.0	2.0	1.9	1.8
Bone: post-yield work	1.0	1.3	1.8	1.1	-0.9	-1.1	-1.1	-1.3
Progressive ratio test 1 active lever presses	2.5	2.7	3.5	-1.6	1.5	1.6	1.6	1.9
Progressive ratio test 1 breakpoint	2.9	3.0	4.0	-1.8	1.5	1.7	1.7	2.0
Progressive ratio test 1 inactive lever presses	1.3	1.5	2.6	-1.4	1.6	0.9	0.5	1.3
Progressive ratio test 2 active lever presses	0.6	0.6	1.1	-0.8	1.0	0.4	-0.6	0.9
Progressive ratio test 2 breakpoint	0.4	0.4	0.6	-0.6	0.8	0.3	-0.8	0.7
Progressive ratio test 2 inactive lever presses	2.2	2.5	4.3	-1.8	2.1	1.0	0.7	1.9
Incentive Sensitization - Responses	0.2	0.2	1.1	0.0	-0.0	0.1	-1.0	-0.3
Incentive Sensitization - Breakpoint	0.4	0.4	1.7	0.1	-0.0	-0.0	-1.3	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.6	0.7	0.3	0.5	0.5
Progressive ratio	4.9	5.7	7.0	2.6	-2.4	-2.6	-2.0	-2.1
Food seeking constrained by brief footshock	0.7	0.8	2.1	-1.0	1.5	0.2	-0.3	0.9
Seeking ratio, punishment vs. effort	4.9	5.9	8.2	-2.8	2.9	2.4	1.6	2.3
Retroperitoneal fat weight	0.0	0.1	0.3	-0.4	0.5	-0.0	-0.6	0.2
Reaction time number correct	0.1	0.1	0.3	-0.2	0.5	0.1	-0.2	-0.0
Reaction time mean minus median	0.7	1.0	1.6	0.9	-0.9	-1.3	-1.1	-0.6
Reaction time mean minus median AUC	0.2	0.3	0.7	0.5	-0.4	-0.9	-0.6	-0.0
Reaction time num false alarms	2.6	3.5	4.8	-2.2	2.2	1.6	1.5	1.8
Reaction time num false alarms AUC	2.1	2.9	3.7	-1.9	1.8	1.7	1.7	1.4
Reaction time trials correct on left	0.1	0.1	0.3	-0.2	0.5	0.1	-0.2	-0.0
Reaction time trials on left	0.1	0.1	0.4	-0.3	0.6	0.1	-0.1	0.1
Reaction time mean	0.1	0.2	0.3	-0.3	0.2	0.4	0.5	0.5
Reaction time mean AUC	0.1	0.1	0.3	-0.2	0.1	0.3	0.5	0.5
Median of all reaction times	0.4	0.6	1.0	-0.6	0.6	0.8	1.0	0.8
Reaction time omissions	0.6	0.8	1.5	-0.9	0.9	0.6	0.6	1.2
Reaction time false alarm rate	1.4	2.0	2.5	-1.6	1.4	1.4	1.4	1.3
Reaction time premature initiation rate	0.1	0.2	0.4	-0.4	0.2	0.7	0.4	0.4
Reaction time premature initiations	0.1	0.1	0.2	-0.3	0.3	0.4	0.0	0.2
Std. dev. reaction times	0.2	0.2	0.4	-0.5	0.3	0.5	0.4	0.6
Reaction time trials completed	0.1	0.1	0.4	-0.3	0.6	0.1	-0.1	0.1
Reaction time trials AUC	0.1	0.1	0.3	-0.3	0.5	0.1	-0.1	-0.0
Run reversals in cocaine runway, females	1.2	1.2	1.6	-1.3	1.2	0.9	1.1	0.9
Run reversals in cocaine runway, males	1.9	1.8	2.4	-1.5	1.3	1.3	0.9	1.5
Latency to leave start box in cocaine runway	1.8	2.0	2.4	1.6	-1.5	-1.2	-1.3	-1.4
Latency to leave start box in cocaine runway, F	3.1	3.4	4.8	2.0	-2.2	-1.4	-1.5	-1.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.4	-0.1	0.6	-0.3	-0.4	-0.0
Std. dev. time between licks in bursts	0.8	1.0	1.5	-1.0	0.9	1.1	1.2	0.7
Total sessions with >9 infusions	0.2	0.2	0.5	-0.1	-0.1	0.1	0.7	0.6
Short access day 1 total inactive lever presses	0.3	0.3	0.5	-0.7	0.6	0.5	0.3	0.7
Short access day 10 total inactive lever presses	0.9	1.0	3.3	0.1	0.6	-1.2	-1.8	-0.3
Short access day 1 total infusions	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2	0.3
Short access day 10 total infusions	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.3	0.2
Short access total infusions	0.1	0.1	0.5	-0.2	0.1	0.1	0.3	0.7
Short access day 1 locomotion	0.1	0.1	0.3	0.2	-0.0	-0.6	-0.2	0.3
Short access day 10 total locomotion	1.4	1.6	2.9	-1.1	0.9	1.2	1.7	1.3
Short access total locomotion	1.0	1.1	1.8	-0.8	0.9	0.6	1.3	1.3
One hour access (0.3 mA shock)	1.0	1.1	1.7	-1.2	1.3	1.0	0.1	1.2
Compulsive drug intake	1.1	1.1	1.7	1.3	-1.3	-0.8	-0.5	-1.2
One hour access (shock baseline)	0.4	0.5	0.7	-0.8	0.8	0.5	-0.4	0.8
Social response proportion	0.4	0.4	0.7	-0.8	0.8	0.4	0.3	0.6
Social responses	1.5	1.9	2.8	-1.5	1.2	1.7	1.5	1.0
Social time	0.0	0.1	0.2	-0.2	-0.1	0.4	0.3	0.1
Soleus weight	0.2	0.7	1.1	-0.8	1.1	0.7	0.7	0.7
Bone: stiffness	1.1	1.7	2.3	-1.5	1.5	1.2	1.1	1.3
Tibialis anterior weight	1.3	4.4	5.5	-2.1	1.7	2.4	2.2	2.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.0	0.5	-0.8	-0.8	-0.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	-0.1	0.1	0.3	0.2
Time to tail flick, test, before self-admin	0.4	0.4	0.7	-0.5	0.2	0.8	0.9	0.5
Time to tail flick, test, after self-admin	1.2	1.2	2.0	0.9	-0.4	-1.3	-1.4	-1.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.0	-1.0	0.6	1.4	1.4	1.1
Delta time to tail flick, test, before/after SA	0.7	0.7	1.3	0.5	0.1	-1.2	-1.1	-0.7
Tibia length	2.4	6.8	14.0	-2.0	0.9	3.7	3.7	1.3
Ambulatory time before self-admin	4.0	4.2	4.6	-2.0	2.2	1.9	2.1	2.0
Ambulatory time after self-admin	1.2	1.3	2.0	-1.0	0.9	1.4	1.4	0.9
Bone: tissue strength	0.4	0.4	0.7	-0.7	0.8	0.3	0.2	0.8
Total heroin consumption	1.6	1.8	3.1	-1.3	1.2	1.2	1.8	1.2
Bone: trabecular number	2.7	4.2	5.3	-2.3	2.2	2.0	1.8	1.8
Bone: trabecular spacing	0.4	0.5	1.0	0.6	-0.7	-0.8	-1.0	-0.4
Bone: trabecular thickness	0.7	0.8	1.0	-1.0	1.0	0.8	0.9	0.9
Bone: trabecular tissue density	1.4	2.0	3.4	-1.5	1.6	0.9	1.0	1.9
Water consumed over 24 hours	0.0	0.0	0.1	0.1	-0.2	-0.0	0.3	-0.0
Number of responses in last shaping day	0.0	0.0	0.0	0.2	-0.2	-0.1	-0.1	-0.0