Hub : Genes

Fbln1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Fbln1	0.09	0.07	3.5e-05	0.04	0.03	0.04	0.01	1.5e-04	7.5e-04	2.1e-04	1.4e-02
2	NAcc	gene expression	Fbln1	0.12	0.07	5.6e-09	0.09	0.07	0.08	0.09	3.5e-10	1.3e-08	1.0e-09	7.9e-11
3	BLA	gene expression	Fbln1	0.36	0.14	1.4e-06	0.08	0.12	0.11	0.07	4.9e-05	4.8e-07	1.6e-06	8.4e-05
4	PL	gene expression	Fbln1	0.19	0.1	3.3e-07	0.06	0.06	0.05	0.05	1.7e-07	2.6e-07	6.2e-06	4.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.4	2.1	1.4	-1.1	-1.2	-0.8
Area under the delay curve	1.9	2.0	3.5	1.6	-1.4	-1.9	0.2
BMI with tail	2.4	7.8	11.9	-2.9	3.4	1.8	2.8
BMI without tail	1.4	3.0	4.5	-2.1	2.1	1.6	0.8
Body weight	1.0	4.2	6.8	-2.4	2.6	1.9	1.1
Weight adjusted by age	1.2	1.3	1.8	-1.2	1.3	1.3	0.4
Bone surface	0.3	0.6	1.3	0.9	-0.5	-1.1	-0.2
Bone volume	0.4	0.6	0.7	0.9	-0.8	-0.8	-0.6
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.3	0.2	0.3	0.7
Number of licking bursts	0.8	0.9	2.4	0.8	-0.7	-0.1	-1.5
Context. condit. distance diff. score	1.6	2.0	3.7	-1.9	1.3	1.2	1.1
Locomotion velocity, session 1	0.3	0.3	0.8	-0.9	0.7	-0.1	0.3
Locomotion distance, session 1	0.3	0.3	0.6	0.2	-0.8	-0.4	-0.8
Locomotion velocity, session 2	1.8	2.1	3.6	-1.9	1.7	1.3	0.4
Locomotion distance, session 2	0.1	0.1	0.2	0.1	-0.1	-0.4	0.4
Locomotion velocity, session 3	1.8	2.1	3.9	-2.0	1.1	1.8	-0.3
Locomotion distance, session 3	0.6	0.7	1.9	-0.3	-0.4	0.7	-1.4
Stereotopy head waving bouts, day 3	1.8	2.1	2.9	-1.7	1.6	0.9	1.4
Stereotopy head waving duration, day 3	3.0	3.6	4.9	-2.2	2.2	1.9	1.1
Locomotion velocity, session 7	2.5	2.8	5.3	-1.9	1.5	2.3	-0.2
Locomotion distance, session 7	0.1	0.1	0.1	-0.4	0.2	0.4	-0.3
Stereotopy head waving bouts, day 7	2.4	2.7	4.4	-2.0	1.5	2.1	-0.1
Stereotopy head waving duration, day 7	1.0	1.2	2.2	-1.3	1.0	1.5	-0.2
Locomotion velocity, session 8	5.2	6.2	10.0	-3.2	2.7	2.3	1.5
Locomotion distance, session 8	0.7	1.0	2.4	-1.5	0.8	0.8	0.6
Degree of sensitization distance	1.4	1.4	3.7	-0.8	1.1	-0.2	1.9
Degree of sensitization stereotypy	1.0	1.1	2.1	-1.2	0.9	1.5	-0.4
Conditioned locomotion	0.2	0.2	0.6	-0.2	0.1	0.8	-0.3
Cocaine response after cond. corrected	0.5	0.6	1.4	0.8	-0.4	-0.4	-1.2
Cocaine response after cond. not corrected	1.1	1.2	3.8	0.9	-0.6	-0.1	-1.9
Cocaine response before conditioning	0.2	0.3	0.8	0.2	-0.5	0.2	-0.9
Saline control response	0.6	0.7	1.9	0.6	-0.8	0.1	-1.4
Bone: connectivity density	0.5	0.8	1.2	1.1	-0.7	-1.1	-0.5
Bone: cortical apparent density	0.8	1.1	1.8	1.0	-0.9	-1.3	0.7
Bone: cortical area	0.7	1.1	2.0	-0.9	1.2	1.4	0.1
Bone: cortical porosity	0.4	0.4	0.8	-0.6	0.7	0.9	0.2
Bone: cortical porosity	0.4	0.5	0.9	-0.7	0.7	0.9	0.2
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.1	-0.2	0.5
Bone: cortical thickness	1.1	1.2	1.8	-0.8	1.4	1.2	1.1
Bone: cortical tissue density	0.7	0.9	1.6	0.9	-0.8	-1.3	0.9
Condit. Reinf. active minus inactive responses	0.6	0.6	1.0	0.9	-0.8	-1.0	-0.1
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.8	1.1	-1.1	-1.3	-0.0
Condit. Reinf. active responses	1.4	1.7	2.5	1.4	-1.4	-1.6	-0.5
Condit. Reinf. inactive responses	0.6	0.7	1.1	0.8	-0.9	-1.1	-0.5
Incentive salience index mean	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.6
Condit. Reinf. lever presses	0.2	0.3	1.1	0.1	-0.2	0.2	-1.0
Condit. Reinf. active minus inactive responses	0.3	0.3	0.4	-0.7	0.6	0.5	0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	0.3	0.1	-0.2
Condit. Reinf. active responses	1.4	1.9	2.6	-1.6	1.4	1.1	1.4
Condit. Reinf. inactive responses	2.7	3.3	4.5	-2.1	1.8	1.5	1.8
Condit. Reinf. lever presses	0.8	1.1	1.6	-1.3	1.1	0.8	0.9
Condit. Reinf. lever reinforcers received	0.9	1.3	1.7	-1.3	1.1	0.9	1.2
Conditioned reinforcement - actives	1.2	1.2	2.7	1.2	-0.9	-1.6	-0.2
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.0
Conditioned locomotion	0.4	0.4	0.7	-0.5	0.8	0.8	-0.4
Patch foraging indifference point 0 sec	0.3	0.5	1.0	1.0	-0.4	-0.5	-0.8
Patch foraging indifference point AUC	0.2	0.2	0.3	0.1	-0.6	-0.5	0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.2	0.2	-0.4	0.7
Delay disc. indifference point, 16s delay	2.9	2.9	4.4	2.0	-1.7	-2.1	-0.5
Delay disc. indifference point, 2s delay	0.3	0.4	0.5	0.7	-0.4	-0.7	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.0	0.2	-0.0	0.5
Delay disc. indifference point, 4s delay	2.0	2.1	4.5	1.3	-1.2	-2.1	0.8
Delay disc. indifference point, 8s delay	1.4	1.4	2.4	1.2	-1.3	-1.5	0.3
Indifference point function ln k	0.8	1.1	2.2	-1.0	1.5	1.0	-0.3
Indifference point function log k	0.8	1.1	2.2	-1.0	1.5	1.0	-0.3
Patch foraging total patch changes 0 sec	0.5	0.8	1.6	1.2	-0.6	-0.5	-1.0
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.5	0.3	0.2	0.7
Patch foraging total patch changes 18 sec	0.8	1.0	1.4	1.2	-1.1	-0.6	-0.9
Patch foraging total patch changes 24 sec	0.2	0.2	0.7	0.2	-0.2	0.4	-0.8
Patch foraging total patch changes 6 sec	0.4	0.6	1.2	1.1	-0.7	-0.8	-0.3
Patch foraging time to switch 0 sec	0.5	0.7	1.9	-1.0	0.2	1.4	0.2
Patch foraging water rate 0 sec	0.1	0.1	0.4	0.1	0.6	0.3	-0.2
Patch foraging water rate 12 sec	0.6	1.0	2.7	1.0	-0.2	-0.4	-1.6
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.7	-0.1	-0.7	-0.5
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.0	0.5	-0.4	0.3
Patch foraging water rate 6 sec	0.4	0.6	1.0	0.8	-0.7	-0.5	-1.0
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.5	1.2	-0.9	-0.5	-0.9
Distance traveled before self-admin	0.1	0.1	0.3	-0.5	0.3	0.5	-0.0
Distance traveled after self-admin	0.9	1.0	2.8	-0.8	0.6	1.7	-0.4
Extensor digitorum longus weight	0.2	1.0	1.8	-1.1	1.3	0.9	0.1
Bone: elastic displacement	0.1	0.1	0.6	-0.1	-0.0	0.1	-0.7
Bone: elastic work	2.5	3.2	4.9	-2.0	1.9	2.2	0.3
Bone: endosteal estimation	1.9	4.2	6.3	-2.5	2.3	2.3	0.3
Bone: endosteal perimeter	2.6	5.3	10.1	-2.3	2.3	3.2	-0.8
Epididymis fat weight	0.2	0.3	0.9	-0.2	0.1	-1.0	0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.0	0.4	0.3	0.5
Delta time in open arm before/after self-admin	0.4	0.4	1.1	-0.4	-0.5	0.2	-1.0
Diff in mean of infusions in LGA sessions	0.7	0.8	2.6	0.1	0.2	-0.7	1.6
Delay discount exponential model param	2.0	2.1	3.8	-1.6	1.4	1.9	-0.3
Extinction: sum of active levers before priming	0.9	0.8	1.9	0.5	-0.3	-1.4	1.1
Active lever presses in extinction session 6	1.7	1.7	3.8	-0.9	1.4	0.4	2.0
Bone: final force	0.9	1.5	3.6	-0.8	1.2	0.3	1.9
Bone: final moment	1.2	2.0	4.8	-0.9	1.5	0.3	2.2
Food consumed during 24 hour testing period	2.9	3.5	4.9	-2.2	2.1	1.7	1.3
Glucose	0.3	0.4	1.0	1.0	-0.7	-0.1	-0.3
Heart weight	0.1	0.1	0.1	0.2	0.3	-0.2	0.4
Delay discount hyperbolic model param	1.6	1.7	3.1	-1.4	1.3	1.8	-0.4
Intermittent access intake day 1-15 change	0.4	0.4	0.6	0.6	-0.8	-0.5	-0.7
Intermittent access intake escalation	0.3	0.3	0.7	0.5	-0.5	-0.3	-0.8
Intermittent access intake escalation 2	0.5	0.5	0.8	0.7	-0.9	-0.6	-0.5
Intermitt. access day 1 inactive lever presses	1.2	1.3	1.6	-1.2	1.0	1.3	1.0
Intermitt. access day 15 inactive lever presses	1.3	1.4	2.7	-1.2	1.2	0.3	1.7
Intermitt. access escalation Index	0.2	0.2	0.5	0.4	0.3	-0.7	0.1
Intermittent access day 1 total infusions	0.2	0.2	0.5	-0.5	0.7	0.0	0.5
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.0	0.2	-0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.6	0.7	0.3	0.2
Intermittent access total infusions	0.3	0.3	0.6	-0.6	0.8	0.5	0.2
Intermittent access day 1 locomotion	0.0	0.1	0.2	-0.0	0.2	0.1	-0.4
Intermittent access day 15 total locomotion	0.3	0.3	0.4	-0.6	0.6	0.7	-0.6
Intermittent access total locomotion	0.5	0.5	0.9	-1.0	0.8	0.7	0.3
Intermittent access standard deviation	0.4	0.4	0.7	-0.8	0.3	0.4	0.9
Left kidney weight	10.4	29.2	43.0	-6.6	6.2	4.3	4.1
Right kidney weight	10.4	29.3	42.0	-6.5	6.2	4.3	4.4
Cocaine induced anxiety	3.4	3.9	6.6	-2.0	2.0	1.0	2.6
Post-drug Anxiety	2.4	2.6	4.4	-1.5	1.7	1.0	2.1
Baseline Anxiety	2.2	2.3	3.4	1.9	-1.4	-1.0	-1.7
Tail length	0.2	0.7	1.5	0.5	-0.9	-0.5	-1.2
Length with tail	0.0	0.2	0.5	-0.3	-0.1	0.3	-0.7
Length without tail	0.2	0.3	1.0	-0.4	0.4	-0.3	1.0
Times rat made contact with spout	0.6	0.7	1.5	-0.8	0.9	-0.3	1.2
Lifetime Intake	0.5	0.6	0.9	-0.9	1.0	0.8	0.2
Liver weight, left	0.7	1.2	3.3	-0.7	0.9	-0.2	1.8
Liver weight, right	0.1	0.2	0.6	-0.8	0.2	0.2	0.1
Locomotor activity	1.5	2.4	4.4	-1.5	2.1	1.7	0.3
Locomotor testing distance	0.1	0.2	0.6	-0.0	0.8	0.5	-0.3
Locomotor testing rearing	0.5	0.7	1.4	-0.7	0.9	1.2	-0.4
Locomotion in novel chamber	1.4	1.8	5.0	1.1	-0.9	-0.2	-2.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	-0.3	0.3	0.8	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.4	0.6	-0.8	0.5	0.6	0.5
Change in fecal boli incidents, locomotor task	0.6	0.6	1.2	0.7	-0.8	-0.3	-1.1
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.5	-1.2	1.2	1.0	0.9
Bouts of movement, locomotor time 1	0.7	0.8	2.0	-0.6	0.9	0.2	1.4
Total resting periods, locomotor time 1	0.8	0.9	2.6	-0.4	0.8	-0.2	1.6
Rest time, locomotor task time 1	1.0	1.1	1.7	-1.0	1.3	0.5	1.2
Distance moved, locomotor task time 1	0.3	0.3	0.9	-0.4	0.3	1.0	-0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.2	-0.2	0.4	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	0.3	0.4	-0.4
Bouts of movement, locomotor time 2	0.8	0.9	3.3	0.0	-0.0	-0.6	1.8
Total resting periods, locomotor time 2	1.1	1.2	4.0	0.1	-0.1	-0.9	2.0
Rest time, locomotor task time 2	2.0	2.3	5.7	1.3	-1.3	-2.4	0.1
Distance moved, locomotor task time 2	2.9	3.3	7.5	-1.8	1.6	2.7	-0.3
Vertical activity count, locomotor time 2	2.7	2.9	6.6	-1.6	1.5	2.6	-0.5
Light reinforcement 1	0.5	1.0	2.0	-0.7	0.5	1.4	-1.1
Light reinforcement 2	1.4	1.9	3.5	-1.3	1.5	1.9	-0.1
Bone: marrow area	1.9	4.1	6.2	-2.5	2.3	2.2	0.4
Bone: maximum diameter	3.9	7.1	9.9	-2.9	3.1	3.1	0.6
Bone: maximum force	1.4	2.4	3.6	-1.4	1.7	1.1	1.9
Bone: maximum moment	1.7	3.0	4.8	-1.5	2.0	1.0	2.2
Mean time between licks in bursts	1.4	1.9	3.5	1.5	-1.2	-0.5	-1.9
Mean num. licks in bursts	2.2	2.7	6.9	-1.4	1.3	-0.2	2.6
Cd content in liver	0.6	0.6	1.1	1.0	-0.7	-1.1	0.1
Co content in liver	0.3	0.4	0.7	-0.5	0.6	0.8	-0.4
Cu content in liver	4.3	5.2	7.2	2.7	-2.6	-1.6	-2.2
Fe content in liver	0.1	0.1	0.3	0.2	0.0	0.5	-0.2
K content in liver	0.2	0.2	0.6	-0.1	-0.1	-0.5	0.8
Mg content in liver	0.2	0.2	0.4	0.3	-0.1	-0.7	0.5
Mn content in liver	0.4	0.4	1.0	-1.0	0.6	0.5	0.2
Na content in liver	1.1	1.1	2.0	1.2	-1.4	-0.8	-0.7
Rb content in liver	0.4	0.5	1.1	1.1	-0.3	-0.9	0.0
Se content in liver	0.5	0.6	0.7	0.7	-0.8	-0.8	-0.7
Sr content in liver	0.4	0.3	0.7	0.4	-0.8	-0.5	-0.5
Zn content in liver	1.1	1.2	1.9	1.0	-1.2	-0.5	-1.4
Bone: minimum diameter	1.4	2.7	5.8	-1.4	1.1	2.4	-1.3
Time in familiar zone, hab. session 1	0.8	0.8	1.2	-0.9	1.1	1.1	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	-0.4	-0.2	-0.3
Total zone transitions, hab. session 1	1.1	1.5	2.6	1.3	-1.6	-1.3	-0.6
Total locomotion distance, hab. session 1	0.0	0.1	0.1	-0.1	-0.4	-0.0	-0.4
Locomotion velocity, hab. session 1	0.0	0.1	0.1	-0.3	-0.3	0.0	-0.3
Time in familiar zone, hab. session 2	0.6	0.6	0.8	0.8	-0.4	-0.9	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.1	-0.3	-0.1	0.4
Total zone transitions, hab. session 2	0.2	0.2	0.3	-0.5	0.5	0.1	0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.4	0.3	0.4	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.4	0.3	0.3	0.0
Novel to familiar place preference ratio	0.1	0.1	0.3	0.1	-0.4	-0.6	0.1
Novelty place preference	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.0
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.1
Total zone transitions, NPP test	0.7	0.9	1.6	0.8	-1.2	-1.3	-0.1
Total locomotion distance, NPP test	0.1	0.1	0.3	0.1	-0.5	0.1	-0.5
Locomotion velocity, NPP test	0.1	0.2	0.3	0.2	-0.6	-0.0	-0.6
Intraocular pressure	0.1	0.1	0.2	-0.4	0.1	0.3	-0.5
Delta distance traveled before/after self-admin	0.4	0.4	1.0	-0.5	0.4	1.0	-0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.1	0.3	0.5	-0.5
Parametrial fat weight	0.2	0.3	0.6	0.4	-0.7	-0.8	0.0
Pavlov. Cond. lever latency	0.4	0.5	1.7	-0.4	0.5	-0.3	1.3
Pavlov. Cond. magazine entry latency	0.8	1.0	1.7	1.3	-1.0	-0.8	-0.8
Pavlov. Cond. change in total contacts	0.4	0.4	1.0	1.0	-0.4	-0.2	-0.8
Pavlov. Cond. index score	0.4	0.5	0.8	0.8	-0.7	-0.2	-0.9
Pavlov. Cond. latency score	0.3	0.4	1.1	0.6	-0.5	0.1	-1.0
Pavlov. Cond. lever contacts	0.6	0.7	2.4	0.4	-0.4	0.4	-1.5
Pavlov. Cond. magazine entry number	0.7	0.9	1.5	-1.2	0.9	0.8	0.7
Pavlov. Cond. intertrial magazine entries	1.7	2.1	3.8	1.7	-1.3	-2.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.3	1.0	-0.9	-0.3	-1.1
Pavlov. Cond. response bias	0.8	1.0	1.5	1.2	-0.8	-0.5	-1.2
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.7	-0.6	-0.5	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.4	0.7	0.8	-0.6	-0.7	0.4
Pavlov. Cond. change in total contacts	0.6	0.8	1.2	-0.9	0.9	0.7	1.1
Pavlov. Cond. index score	0.1	0.1	0.4	-0.1	0.2	0.0	0.6
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.2	0.4	0.3	0.6
Pavlov. Cond. lever contacts	0.5	0.6	0.7	-0.8	0.9	0.6	0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.1	-0.1	-0.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.7	-0.9	0.9	0.2	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.1	0.2	0.2	0.5
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.4	0.5	0.2	0.8
Time in closed arm before self-admin	1.2	1.3	2.0	1.4	-1.3	-1.1	-0.7
Time in closed arm after self-admin	0.3	0.3	0.5	0.5	-0.2	0.4	-0.7
Time in open arm before self-admin	0.3	0.3	0.6	-0.6	0.4	0.8	-0.1
Time in open arm after self-admin	0.4	0.4	1.2	-1.1	0.3	0.6	0.2
Bone: periosteal estimation	1.9	3.9	5.5	-2.2	2.3	2.3	0.3
Bone: periosteal perimeter	2.7	4.5	8.3	-2.1	2.2	2.9	-0.8
Bone: post-yield work	0.8	1.1	2.8	0.3	0.2	-1.2	1.7
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	0.3	0.3	-0.9	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	0.3	0.2	-0.8	0.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	-0.5	0.7	0.2	0.4
Progressive ratio test 2 active lever presses	0.8	0.9	2.7	-0.2	0.2	-0.9	1.6
Progressive ratio test 2 breakpoint	0.9	1.0	2.9	-0.3	0.3	-0.8	1.7
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.7	-0.7	0.5	-0.2	1.3
Incentive Sensitization - Responses	1.4	1.4	4.6	-0.7	0.6	-0.6	2.1
Incentive Sensitization - Breakpoint	1.6	1.7	5.1	-0.8	0.8	-0.5	2.3
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	-0.7	0.5	0.5	1.0
Progressive ratio	0.2	0.3	0.6	0.5	-0.4	-0.8	0.3
Food seeking constrained by brief footshock	0.5	0.7	1.1	-0.7	0.9	1.0	0.3
Seeking ratio, punishment vs. effort	0.7	0.9	1.7	-0.9	1.0	1.3	0.3
Retroperitoneal fat weight	1.2	3.8	6.0	-2.4	2.2	1.5	1.4
Reaction time number correct	0.3	0.4	0.7	0.7	-0.6	-0.0	-0.8
Reaction time mean minus median	0.1	0.2	0.3	0.4	-0.6	-0.4	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.5	0.1	0.2	0.4
Reaction time num false alarms	0.6	0.8	2.4	0.4	-0.7	0.3	-1.5
Reaction time num false alarms AUC	0.5	0.7	2.0	0.3	-0.8	0.0	-1.4
Reaction time trials correct on left	0.3	0.4	0.7	0.7	-0.6	-0.0	-0.8
Reaction time trials on left	0.3	0.4	0.7	0.8	-0.7	-0.1	-0.8
Reaction time mean	0.6	0.9	1.4	0.9	-1.2	-1.1	0.3
Reaction time mean AUC	0.7	1.0	1.6	0.8	-1.3	-1.2	0.3
Median of all reaction times	0.9	1.3	2.0	1.1	-1.3	-1.4	0.4
Reaction time omissions	1.0	1.4	2.2	1.5	-1.1	-1.4	-0.1
Reaction time false alarm rate	0.1	0.2	0.7	-0.1	-0.3	0.2	-0.8
Reaction time premature initiation rate	1.5	2.0	4.7	-1.2	1.2	0.4	2.2
Reaction time premature initiations	0.6	0.9	2.3	-0.7	0.7	0.3	1.5
Std. dev. reaction times	0.4	0.5	1.0	0.6	-0.9	-1.0	0.1
Reaction time trials completed	0.3	0.4	0.7	0.8	-0.7	-0.1	-0.8
Reaction time trials AUC	0.2	0.2	0.5	0.5	-0.4	0.2	-0.7
Run reversals in cocaine runway, females	2.0	1.9	3.6	1.5	-1.1	-0.7	-1.9
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.6	0.4	0.4	-0.5
Latency to leave start box in cocaine runway	1.1	1.2	2.0	-1.2	1.4	1.2	0.2
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-0.5	1.0	0.5	0.2
Latency to leave start box in cocaine runway, M	1.2	1.2	1.8	-1.3	1.1	1.2	0.6
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.4	-0.0	-0.2	0.0
Total sessions with >9 infusions	0.9	1.0	2.0	-0.8	0.8	1.4	-0.9
Short access day 1 total inactive lever presses	1.1	1.2	1.9	-1.3	1.4	1.2	0.3
Short access day 10 total inactive lever presses	1.1	1.2	1.9	-1.4	0.8	1.4	0.5
Short access day 1 total infusions	0.8	0.8	1.2	-1.0	1.0	1.1	-0.1
Short access day 10 total infusions	0.3	0.3	0.8	-0.5	0.9	0.6	-0.0
Short access total infusions	1.7	1.9	2.6	-1.5	1.6	1.6	0.3
Short access day 1 locomotion	0.1	0.1	0.4	-0.1	0.0	0.7	-0.3
Short access day 10 total locomotion	0.2	0.2	0.7	0.1	-0.0	0.3	-0.8
Short access total locomotion	0.9	0.9	2.3	-0.7	0.8	1.5	-0.5
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	0.1	0.5	-0.1
Compulsive drug intake	0.0	0.0	0.1	0.0	-0.2	0.0	0.2
One hour access (shock baseline)	0.1	0.1	0.4	-0.1	0.1	0.4	-0.6
Social response proportion	0.6	0.6	1.1	-0.8	0.8	1.1	0.1
Social responses	0.6	0.8	1.4	-0.9	0.9	1.2	-0.3
Social time	1.2	1.5	2.4	1.6	-1.1	-1.5	-0.5
Soleus weight	0.4	1.1	3.0	-0.6	0.9	-0.5	1.7
Bone: stiffness	0.3	0.6	1.2	-0.2	0.6	0.8	1.1
Tibialis anterior weight	0.0	0.0	0.1	0.1	0.1	-0.4	0.1
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.4	0.5	-0.0	-1.5	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.5	-0.2	-0.7	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.6	-0.7	0.5	0.8	-0.3
Time to tail flick, test, after self-admin	1.2	1.3	3.0	1.7	-0.8	-0.8	-0.8
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.6	-0.7	0.8	0.7	0.7
Delta time to tail flick, test, before/after SA	2.3	2.1	4.0	2.0	-1.3	-1.5	-0.6
Tibia length	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.3
Ambulatory time before self-admin	0.1	0.1	0.3	-0.5	0.1	0.5	0.1
Ambulatory time after self-admin	0.2	0.2	0.5	0.2	-0.1	0.5	-0.7
Bone: tissue strength	0.4	0.4	0.5	0.7	-0.1	-0.7	0.7
Total heroin consumption	1.2	1.4	2.8	-1.1	1.0	0.7	1.7
Bone: trabecular number	1.2	1.9	2.4	1.5	-1.5	-0.9	-1.6
Bone: trabecular spacing	4.4	5.7	7.5	-2.7	2.7	2.4	1.3
Bone: trabecular thickness	0.3	0.3	0.6	0.5	-0.8	-0.3	-0.5
Bone: trabecular tissue density	0.2	0.3	0.5	0.2	-0.7	-0.5	0.7
Water consumed over 24 hours	1.5	1.9	2.6	-1.6	1.6	1.2	0.9
Number of responses in last shaping day	0.0	0.0	0.1	0.3	-0.1	0.0	-0.3