Hub : Genes

Fastkd5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Fastkd5	0.03	0.03	4.9e-03	0.01	0.01	0.01	0.01	3.4e-02	2.6e-02	3.1e-02	5.9e-02
2	Adipose	intron excision ratio	chr3_138286180_138299471	0.03	0.03	3.1e-03	0.01	0	-0	0	6.2e-02	1.1e-01	4.0e-01	2.3e-01
3	Brain	intron excision ratio	chr3_138273098_138300717	0.05	0.05	6.0e-05	0.06	0.04	0.05	0.06	1.8e-06	6.0e-05	2.0e-05	3.7e-06
4	BLA	intron excision ratio	chr3_138273098_138300717	0.14	0.12	2.8e-05	0.04	0.02	0	0.03	6.1e-03	4.7e-02	1.9e-01	1.3e-02
5	PL	intron excision ratio	chr3_138273098_138300717	0.03	0.03	3.5e-03	0.02	0.02	0.02	0.02	2.1e-03	4.1e-03	3.9e-03	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.4	0.6	0.7	-0.6	-0.6	-0.4
Area under the delay curve	0.2	0.3	0.4	-0.6	-0.6	0.6	0.3	0.3
BMI with tail	0.1	0.5	0.6	0.8	0.6	-0.7	-0.6	-0.7
BMI without tail	2.5	7.5	8.0	2.8	2.8	-2.8	-2.6	-2.7
Body weight	3.4	15.0	16.4	4.0	4.0	-3.8	-3.8	-3.7
Weight adjusted by age	2.0	3.0	4.7	2.0	2.2	-1.3	-1.8	-1.1
Bone surface	0.4	0.7	1.0	1.0	1.0	-0.7	-0.8	-0.7
Bone volume	0.4	0.7	1.0	1.0	1.0	-0.7	-0.8	-0.7
Breakpoint value in progressive ratio session	2.9	3.5	4.0	1.8	1.7	-1.9	-2.0	-1.9
Number of licking bursts	0.1	0.1	0.3	-0.3	-0.3	0.5	0.3	0.4
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1	0.1
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	0.6	-0.4	-0.5	-0.3
Locomotion distance, session 1	0.1	0.1	0.3	0.4	0.5	-0.3	-0.4	-0.1
Locomotion velocity, session 2	0.1	0.2	0.3	-0.3	-0.4	0.5	0.5	0.3
Locomotion distance, session 2	1.2	1.7	1.9	1.3	1.3	-1.4	-1.3	-1.2
Locomotion velocity, session 3	1.2	1.4	1.6	1.3	1.3	-1.1	-1.1	-1.2
Locomotion distance, session 3	6.7	7.3	8.0	2.8	2.8	-2.5	-2.8	-2.5
Stereotopy head waving bouts, day 3	1.2	1.4	1.9	-1.2	-1.2	1.2	1.4	0.9
Stereotopy head waving duration, day 3	1.0	1.2	1.8	-1.1	-1.1	1.0	1.4	0.8
Locomotion velocity, session 7	0.7	0.8	0.8	0.9	0.9	-0.8	-0.9	-0.8
Locomotion distance, session 7	0.5	0.6	0.9	0.8	0.7	-0.7	-0.9	-0.7
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	0.7	0.7	-0.6	-0.5	-0.8
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.4	0.4	-0.3	-0.2	-0.4
Locomotion velocity, session 8	0.2	0.2	0.3	0.5	0.6	-0.5	-0.5	-0.4
Locomotion distance, session 8	1.5	2.2	2.7	1.5	1.7	-1.5	-1.6	-1.2
Degree of sensitization distance	2.2	2.2	2.7	-1.6	-1.6	1.4	1.5	1.4
Degree of sensitization stereotypy	2.5	2.7	2.9	1.7	1.7	-1.6	-1.6	-1.7
Conditioned locomotion	3.8	4.3	5.0	2.2	2.2	-1.9	-2.1	-2.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.4	0.3	0.3	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.5	-0.5	0.3	0.4	0.4
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	-0.4	0.1	0.4	0.1
Saline control response	8.5	11.3	12.5	3.4	3.4	-3.3	-3.5	-3.2
Bone: connectivity density	0.0	0.0	0.1	0.2	0.3	-0.1	0.1	-0.1
Bone: cortical apparent density	1.0	1.4	1.5	1.2	1.2	-1.1	-1.0	-1.2
Bone: cortical area	3.8	5.8	6.2	2.4	2.4	-2.4	-2.5	-2.4
Bone: cortical porosity	0.1	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.2
Bone: cortical porosity	0.5	0.6	0.7	0.7	0.7	-0.8	-0.8	-0.7
Bone: cortical thickness	1.7	2.8	3.0	1.7	1.7	-1.6	-1.7	-1.6
Bone: cortical thickness	0.3	0.4	0.4	0.7	0.6	-0.5	-0.6	-0.6
Bone: cortical tissue density	0.8	1.1	1.2	1.1	1.1	-1.0	-0.9	-1.1
Condit. Reinf. active minus inactive responses	0.8	0.9	1.2	0.9	0.8	-1.0	-0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.0	0.9	0.9	-1.0	-0.8	-1.0
Condit. Reinf. active responses	0.6	0.8	0.9	0.8	0.8	-1.0	-0.8	-1.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.1	-0.2	-0.1	-0.1
Incentive salience index mean	0.5	0.6	0.7	0.7	0.6	-0.9	-0.7	-0.9
Condit. Reinf. lever presses	0.1	0.1	0.2	0.2	0.2	-0.5	-0.4	-0.4
Condit. Reinf. active minus inactive responses	2.4	3.1	4.4	1.8	1.7	-1.8	-1.4	-2.1
Condit. Reinf. active-inactive response ratio	2.3	2.7	3.9	1.7	1.5	-1.6	-1.3	-2.0
Condit. Reinf. active responses	3.7	5.1	6.3	2.3	2.2	-2.3	-1.8	-2.5
Condit. Reinf. inactive responses	0.4	0.5	0.7	0.8	0.9	-0.6	-0.7	-0.6
Condit. Reinf. lever presses	1.4	2.0	2.4	1.4	1.4	-1.5	-1.2	-1.4
Condit. Reinf. lever reinforcers received	2.8	3.8	4.8	2.0	1.9	-2.0	-1.6	-2.2
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.2	-0.1	-0.3	0.6	-0.0
Conditioned reinforcement - inactives	0.1	0.2	0.5	0.3	0.1	-0.5	0.1	-0.7
Conditioned locomotion	0.1	0.1	0.2	-0.2	-0.3	0.1	0.5	0.1
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.2	-0.7	-0.3	-0.4
Patch foraging indifference point AUC	0.8	1.1	1.5	1.1	1.1	-1.2	-1.0	-1.0
Delay disc. indifference point, 0s delay	1.9	2.1	2.7	-1.7	-1.6	1.3	1.4	1.2
Delay disc. indifference point, 16s delay	0.5	0.6	0.8	-0.9	-0.9	0.8	0.8	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.1	0.1
Delay disc. indifference point, 24s delay	2.9	3.3	4.3	-1.7	-1.7	2.1	1.5	2.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	0.2	0.2	-0.1	-0.6	-0.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.4	-0.7	-0.6	0.6	0.5	0.4
Indifference point function ln k	0.0	0.1	0.2	0.3	0.2	-0.0	-0.4	-0.1
Indifference point function log k	0.0	0.1	0.2	0.3	0.2	-0.0	-0.4	-0.1
Patch foraging total patch changes 0 sec	0.1	0.3	0.6	0.4	0.3	-0.8	-0.4	-0.5
Patch foraging total patch changes 12 sec	0.5	0.7	1.1	0.9	0.7	-1.1	-0.7	-0.6
Patch foraging total patch changes 18 sec	0.3	0.4	0.7	-0.7	-0.6	0.4	0.6	0.9
Patch foraging total patch changes 24 sec	0.7	1.1	1.5	-1.2	-1.2	0.7	1.1	1.0
Patch foraging total patch changes 6 sec	0.8	1.2	2.2	0.9	0.9	-1.5	-0.8	-1.2
Patch foraging time to switch 0 sec	1.4	2.8	3.4	-1.8	-1.6	1.6	1.6	1.6
Patch foraging water rate 0 sec	3.0	6.4	7.3	2.7	2.4	-2.4	-2.5	-2.6
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	-0.3
Patch foraging water rate 18 sec	0.3	0.5	0.7	0.6	0.5	-0.8	-0.7	-0.8
Patch foraging water rate 24 sec	0.3	0.5	0.8	0.9	0.8	-0.1	-0.8	-0.6
Patch foraging water rate 6 sec	1.9	2.8	3.7	1.9	1.9	-1.3	-1.6	-1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	-0.5	-0.4	0.5	0.4	0.8
Distance traveled before self-admin	4.6	6.1	6.9	2.4	2.4	-2.6	-2.4	-2.6
Distance traveled after self-admin	1.6	2.0	2.6	1.6	1.6	-1.5	-1.3	-1.0
Extensor digitorum longus weight	0.0	0.2	0.3	0.4	0.4	-0.4	-0.6	-0.3
Bone: elastic displacement	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	-0.1
Bone: elastic work	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.1
Bone: endosteal estimation	0.7	1.4	1.6	1.2	1.2	-1.3	-1.2	-1.2
Bone: endosteal perimeter	2.6	5.5	5.8	2.4	2.3	-2.4	-2.4	-2.3
Epididymis fat weight	0.1	0.3	0.8	-0.2	-0.2	0.9	-0.3	0.7
Delta time in closed arm before/after self-admin	0.7	0.6	0.8	-0.8	-0.8	0.9	0.5	0.9
Delta time in open arm before/after self-admin	0.4	0.4	0.7	0.8	0.8	-0.7	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.3	0.3	-0.2	-0.5	-0.0
Delay discount exponential model param	0.2	0.3	0.5	0.5	0.6	-0.7	-0.2	-0.4
Extinction: sum of active levers before priming	1.5	1.6	2.5	1.3	1.6	-1.3	-1.1	-1.0
Active lever presses in extinction session 6	0.1	0.1	0.2	0.1	0.1	-0.3	-0.1	-0.4
Bone: final force	3.7	6.0	6.3	2.5	2.4	-2.5	-2.3	-2.5
Bone: final moment	2.9	4.6	4.8	2.2	2.1	-2.2	-2.1	-2.2
Food consumed during 24 hour testing period	0.8	1.2	1.6	-1.0	-0.9	1.2	1.0	1.1
Glucose	0.1	0.2	0.2	0.4	0.4	-0.4	-0.5	-0.3
Heart weight	2.7	4.2	5.3	2.3	2.1	-1.8	-2.0	-2.0
Delay discount hyperbolic model param	0.2	0.2	0.4	0.5	0.6	-0.6	-0.2	-0.4
Intermittent access intake day 1-15 change	0.1	0.2	0.4	0.5	0.4	-0.5	-0.3	-0.6
Intermittent access intake escalation	0.1	0.3	0.4	0.5	0.5	-0.6	-0.5	-0.5
Intermittent access intake escalation 2	0.1	0.1	0.1	0.3	0.4	-0.4	-0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.5	1.3	0.6	0.4	-0.6	-0.2	-1.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	-0.3	-0.4	-0.1	0.5	-0.3
Intermitt. access escalation Index	0.2	0.3	0.5	0.4	0.3	-0.5	-0.7	-0.5
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.0	0.2	-0.5	-0.0	-0.1
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.2	0.3	-0.7	-0.1	-0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.2	0.3	-0.7	-0.1	-0.6
Intermittent access total infusions	0.1	0.1	0.4	0.2	0.2	-0.6	-0.2	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.3	0.0	0.5	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.3	0.2	0.2	-0.6	-0.1	-0.4
Intermittent access total locomotion	0.3	0.3	0.6	0.5	0.5	-0.8	-0.4	-0.5
Intermittent access standard deviation	0.2	0.3	0.6	0.6	0.5	-0.7	-0.0	-0.8
Left kidney weight	0.0	0.2	0.4	0.3	0.2	-0.6	-0.3	-0.5
Right kidney weight	0.0	0.2	0.4	0.3	0.2	-0.6	-0.3	-0.4
Cocaine induced anxiety	3.9	5.5	6.8	-2.4	-2.6	2.4	2.3	2.0
Post-drug Anxiety	3.7	3.9	4.9	-1.9	-2.2	2.1	2.0	1.6
Baseline Anxiety	0.1	0.1	0.1	0.3	0.3	-0.1	-0.3	-0.3
Tail length	4.6	18.1	19.0	4.2	4.3	-4.4	-4.2	-4.2
Length with tail	5.9	25.8	27.8	5.3	5.3	-4.8	-5.1	-5.0
Length without tail	2.2	7.2	8.1	2.8	2.8	-2.4	-2.8	-2.4
Times rat made contact with spout	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.0	0.2
Lifetime Intake	0.3	0.3	0.6	0.5	0.6	-0.8	-0.5	-0.5
Liver weight, left	0.9	1.5	1.9	1.3	1.2	-1.2	-1.4	-1.1
Liver weight, right	0.4	0.6	1.2	0.8	0.6	-0.6	-1.1	-0.7
Locomotor activity	0.2	0.2	0.8	0.5	0.3	-0.1	-0.9	-0.3
Locomotor testing distance	0.1	0.2	0.3	-0.4	-0.6	0.5	0.0	0.3
Locomotor testing rearing	0.1	0.3	0.4	0.6	0.4	-0.6	-0.5	-0.5
Locomotion in novel chamber	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.2	-0.3
Locomotion in novel chamber post-restriction	0.4	0.7	0.9	0.9	0.7	-0.7	-1.0	-0.8
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.1	0.1	0.3	-0.0	0.5
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	-0.4	-0.4	0.9	0.6	0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	0.2	0.2	-0.0	0.2
Bouts of movement, locomotor time 1	1.2	1.3	1.9	-1.4	-1.4	0.9	1.1	0.9
Total resting periods, locomotor time 1	1.0	1.1	1.7	-1.2	-1.3	0.8	1.1	0.8
Rest time, locomotor task time 1	0.1	0.2	0.3	-0.5	-0.5	0.2	0.5	0.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.0	0.2	-0.1	0.0	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.4	0.3	0.3	-0.0	-0.6	-0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1	-0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.4	-0.7	-0.6	-0.2	0.6	-0.5
Total resting periods, locomotor time 2	0.2	0.3	0.5	-0.6	-0.6	-0.2	0.7	-0.5
Rest time, locomotor task time 2	0.2	0.3	0.9	-0.5	-0.5	0.3	0.9	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	0.1	-0.2	-0.4	-0.1
Vertical activity count, locomotor time 2	0.2	0.3	0.5	0.4	0.4	-0.5	-0.7	-0.6
Light reinforcement 1	0.6	1.6	1.9	1.2	1.3	-1.3	-1.0	-1.4
Light reinforcement 2	0.5	0.7	0.9	0.9	0.9	-0.7	-1.0	-0.7
Bone: marrow area	0.6	1.3	1.5	1.2	1.1	-1.2	-1.1	-1.2
Bone: maximum diameter	4.7	8.7	9.0	3.0	2.9	-3.0	-3.0	-2.9
Bone: maximum force	1.1	1.9	2.1	1.4	1.4	-1.4	-1.3	-1.4
Bone: maximum moment	0.5	0.9	1.0	1.0	1.0	-0.9	-1.0	-0.9
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	0.2	0.0	0.0
Mean num. licks in bursts	0.0	0.1	0.1	0.3	0.2	-0.2	-0.4	-0.2
Cd content in liver	2.4	2.7	3.5	1.5	1.5	-1.9	-1.4	-1.8
Co content in liver	2.6	3.0	3.4	1.8	1.8	-1.8	-1.5	-1.8
Cu content in liver	3.3	3.9	4.3	2.1	2.0	-1.9	-1.9	-1.9
Fe content in liver	0.1	0.1	0.2	0.1	0.1	-0.4	0.1	-0.4
K content in liver	0.3	0.3	0.5	0.7	0.7	-0.1	-0.7	-0.2
Mg content in liver	3.4	3.5	3.9	2.0	2.0	-1.6	-1.9	-1.7
Mn content in liver	2.7	3.0	3.3	1.8	1.7	-1.6	-1.8	-1.7
Na content in liver	0.3	0.3	0.5	-0.6	-0.6	0.4	0.7	0.6
Rb content in liver	3.7	4.3	4.9	2.1	2.1	-1.9	-2.2	-2.0
Se content in liver	1.1	1.3	1.6	1.2	1.3	-1.1	-1.0	-1.1
Sr content in liver	1.0	0.9	1.7	0.7	0.7	-1.1	-0.8	-1.3
Zn content in liver	1.8	1.9	2.3	1.5	1.5	-1.3	-1.3	-1.4
Bone: minimum diameter	1.9	3.4	3.6	1.9	1.8	-1.9	-1.9	-1.8
Time in familiar zone, hab. session 1	1.4	1.4	1.6	-1.2	-1.2	1.2	1.1	1.3
Time in novel zone, hab. session 1	0.4	0.4	0.5	0.7	0.7	-0.6	-0.6	-0.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.3
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.2	0.2	-0.3	-0.1	-0.1
Time in familiar zone, hab. session 2	1.6	1.7	2.1	-1.3	-1.4	1.2	1.4	1.2
Time in novel zone, hab. session 2	1.6	1.6	1.9	1.3	1.4	-1.1	-1.4	-1.2
Total zone transitions, hab. session 2	2.6	3.3	3.8	1.8	1.9	-1.7	-1.9	-1.7
Total locomotion distance, hab. session 2	0.5	0.6	0.9	0.8	0.9	-0.8	-0.7	-0.7
Locomotion velocity, hab. session 2	0.2	0.2	0.3	0.4	0.6	-0.5	-0.4	-0.4
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.4	-0.4	0.2	0.1	0.4
Novelty place preference	0.3	0.3	0.4	-0.6	-0.6	0.5	0.4	0.6
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	-0.5	0.3	0.2	0.4
Total zone transitions, NPP test	0.1	0.2	0.3	0.4	0.5	-0.4	-0.4	-0.3
Total locomotion distance, NPP test	0.1	0.1	0.2	0.3	0.4	-0.3	-0.2	-0.2
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.0	0.1	0.1	0.1	0.1
Intraocular pressure	0.1	0.1	0.2	0.1	0.2	-0.4	-0.1	-0.5
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	0.4	-0.2	-0.1	0.2
Delta ambulatory time before/after self-admin	0.7	0.9	1.7	-0.7	-0.7	0.9	0.8	1.3
Parametrial fat weight	0.2	0.4	0.9	-0.5	-0.6	0.9	0.2	0.8
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.5	0.4	-0.3	-0.3	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.4	0.4	-0.7	-0.3	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.2
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.0	-0.1	0.0	0.0
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.3	-0.2	0.1	0.3	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.1	0.1
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	-0.8	-0.8	0.9	0.7	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.0	-0.1
Pavlov. Cond. response bias	0.4	0.5	0.8	0.7	0.7	-0.9	-0.7	-0.7
Pavlov. Cond. lever latency	4.6	6.2	6.6	-2.5	-2.6	2.6	2.2	2.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.0	-0.2	0.1	-0.1
Pavlov. Cond. change in total contacts	2.9	4.6	5.2	2.3	2.2	-2.0	-2.1	-2.2
Pavlov. Cond. index score	3.0	4.0	4.4	2.0	2.0	-2.1	-1.8	-2.0
Pavlov. Cond. latency score	2.4	3.2	3.8	1.8	1.8	-2.0	-1.6	-1.8
Pavlov. Cond. lever contacts	3.9	5.4	5.8	2.3	2.4	-2.4	-2.1	-2.4
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-0.9	-0.8	0.9	0.7	1.0
Pavlov. Cond. intertrial magazine entries	0.8	1.2	1.6	-1.1	-1.1	1.3	0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.3	3.6	1.9	1.8	-1.9	-1.7	-1.9
Pavlov. Cond. response bias	4.1	5.6	5.9	2.4	2.4	-2.4	-2.2	-2.4
Time in closed arm before self-admin	0.3	0.3	0.4	-0.6	-0.5	0.6	0.5	0.6
Time in closed arm after self-admin	1.2	1.2	1.7	-1.2	-1.1	1.2	0.7	1.3
Time in open arm before self-admin	0.1	0.1	0.2	-0.3	-0.4	0.0	-0.1	-0.3
Time in open arm after self-admin	0.4	0.4	0.7	0.8	0.8	-0.7	-0.3	-0.5
Bone: periosteal estimation	2.4	5.1	5.2	2.3	2.2	-2.3	-2.2	-2.3
Bone: periosteal perimeter	3.1	5.3	5.7	2.3	2.2	-2.3	-2.4	-2.3
Bone: post-yield work	0.5	0.8	1.0	-0.9	-0.8	0.9	1.0	0.8
Progressive ratio test 1 active lever presses	1.7	2.1	2.7	1.3	1.3	-1.6	-1.4	-1.5
Progressive ratio test 1 breakpoint	1.7	2.1	2.8	1.3	1.3	-1.7	-1.4	-1.5
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.3	0.3	-0.5	-0.0	-0.7
Progressive ratio test 2 active lever presses	0.4	0.4	0.8	0.6	0.7	-0.9	-0.6	-0.4
Progressive ratio test 2 breakpoint	0.5	0.5	0.9	0.7	0.8	-1.0	-0.7	-0.5
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.0	0.8	0.5	-1.0	-0.3	-1.0
Incentive Sensitization - Responses	0.3	0.4	0.6	0.5	0.7	-0.8	-0.7	-0.1
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.3	0.5	-0.6	-0.6	0.1
Sum of active levers in priming session hrs 5-6	0.7	0.6	0.8	0.9	0.8	-0.8	-0.8	-0.8
Progressive ratio	2.8	4.4	6.4	-2.2	-2.1	1.7	2.5	1.9
Food seeking constrained by brief footshock	0.3	0.3	0.6	0.2	0.0	-0.8	-0.7	-0.8
Seeking ratio, punishment vs. effort	2.5	3.6	5.8	1.9	1.7	-1.5	-2.4	-1.8
Retroperitoneal fat weight	0.6	2.5	3.5	-1.6	-1.7	1.6	0.9	1.9
Reaction time number correct	0.1	0.2	0.3	0.6	0.3	-0.3	-0.0	-0.5
Reaction time mean minus median	0.4	1.0	1.4	-0.9	-0.9	1.0	1.0	1.2
Reaction time mean minus median AUC	0.2	0.5	0.8	-0.7	-0.7	0.8	0.7	0.9
Reaction time num false alarms	1.8	2.5	3.7	1.5	1.5	-1.6	-1.9	-1.3
Reaction time num false alarms AUC	1.6	2.5	3.8	1.6	1.5	-1.5	-2.0	-1.4
Reaction time trials correct on left	0.1	0.2	0.3	0.6	0.3	-0.3	-0.0	-0.5
Reaction time trials on left	0.1	0.2	0.4	0.6	0.4	-0.4	-0.1	-0.6
Reaction time mean	0.0	0.0	0.2	-0.0	0.1	-0.0	0.0	0.4
Reaction time mean AUC	0.0	0.0	0.2	-0.1	0.0	0.0	0.1	0.4
Median of all reaction times	0.0	0.1	0.1	0.2	0.3	-0.3	-0.2	0.2
Reaction time omissions	0.6	0.9	1.1	0.9	0.9	-1.0	-1.0	-0.9
Reaction time false alarm rate	1.1	1.6	2.8	1.1	1.2	-1.2	-1.7	-1.0
Reaction time premature initiation rate	0.2	0.3	0.5	-0.5	-0.7	0.4	0.7	-0.2
Reaction time premature initiations	0.2	0.3	0.7	-0.4	-0.6	0.3	0.8	-0.2
Std. dev. reaction times	0.1	0.1	0.2	0.4	0.4	-0.2	-0.4	0.0
Reaction time trials completed	0.1	0.2	0.4	0.6	0.4	-0.4	-0.1	-0.6
Reaction time trials AUC	0.1	0.3	0.5	0.7	0.4	-0.5	-0.2	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.3	-0.5	-0.5	0.4	-0.4
Run reversals in cocaine runway, males	0.7	0.7	1.2	0.8	0.7	-1.1	-0.6	-1.0
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.7	-0.6	0.5	-0.1	0.8
Latency to leave start box in cocaine runway, F	0.9	1.0	1.6	-1.2	-1.0	1.0	0.5	1.2
Latency to leave start box in cocaine runway, M	0.7	0.6	1.2	0.6	0.6	-0.9	-1.1	-0.7
Std. dev. time between licks in bursts	0.3	0.5	0.6	0.7	0.8	-0.6	-0.6	-0.7
Total sessions with >9 infusions	0.4	0.5	0.8	0.7	0.9	-0.8	-0.7	-0.3
Short access day 1 total inactive lever presses	2.4	3.1	3.9	-1.8	-1.9	1.6	2.0	1.4
Short access day 10 total inactive lever presses	1.2	2.8	3.8	-1.5	-1.7	1.7	2.0	1.5
Short access day 1 total infusions	0.1	0.1	0.4	-0.2	-0.1	0.2	0.2	0.6
Short access day 10 total infusions	0.0	0.0	0.1	-0.3	-0.0	-0.3	0.1	-0.1
Short access total infusions	0.1	0.1	0.3	0.3	0.5	-0.5	-0.3	0.0
Short access day 1 locomotion	0.7	0.8	1.5	-0.8	-0.8	0.8	0.9	1.2
Short access day 10 total locomotion	0.0	0.1	0.2	-0.0	0.0	0.0	0.4	0.3
Short access total locomotion	0.1	0.1	0.2	-0.1	-0.1	0.1	0.4	0.4
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.0	-0.2	-0.3	0.3	-0.1
Compulsive drug intake	1.9	2.2	2.8	-1.4	-1.6	1.4	1.7	1.3
One hour access (shock baseline)	0.5	0.8	1.1	0.8	0.9	-1.1	-0.7	-0.9
Social response proportion	0.9	1.0	1.4	1.1	1.2	-0.7	-1.1	-0.8
Social responses	4.4	5.6	6.1	2.4	2.4	-2.2	-2.3	-2.5
Social time	0.3	0.4	0.5	0.7	0.6	-0.6	-0.7	-0.5
Soleus weight	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2	0.0
Bone: stiffness	2.6	4.3	4.7	2.1	2.0	-2.2	-2.0	-2.1
Tibialis anterior weight	1.2	4.2	5.0	1.9	1.9	-2.2	-2.0	-2.1
Time to tail flick, vehicle, before self-admin	1.3	1.4	2.1	-1.2	-1.1	1.1	1.4	0.9
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.2	-0.7	-0.5	0.8	0.1	1.1
Time to tail flick, test, before self-admin	1.4	1.4	3.2	1.2	1.1	-0.9	-1.8	-0.7
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-0.7	-0.9	0.9	0.6	0.7
Delta time to tail flick, vehicle, before/after SA	3.1	3.0	4.6	1.8	1.7	-1.5	-2.1	-1.3
Delta time to tail flick, test, before/after SA	1.6	1.7	3.3	-1.2	-1.2	1.1	1.8	1.0
Tibia length	5.1	14.1	15.1	3.8	3.8	-3.9	-3.5	-3.8
Ambulatory time before self-admin	3.1	4.7	5.4	2.1	2.2	-2.3	-2.0	-2.2
Ambulatory time after self-admin	2.8	3.3	4.3	2.0	2.1	-1.9	-1.6	-1.4
Bone: tissue strength	0.1	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.1
Total heroin consumption	3.5	4.1	5.0	1.9	1.9	-2.0	-2.2	-1.9
Bone: trabecular number	0.6	0.9	1.2	1.1	1.1	-0.9	-0.9	-0.9
Bone: trabecular spacing	0.1	0.1	0.2	-0.3	-0.3	0.0	0.5	-0.1
Bone: trabecular thickness	0.4	0.5	0.8	0.7	0.7	-0.6	-0.9	-0.5
Bone: trabecular tissue density	2.1	3.1	4.0	1.7	1.7	-1.7	-2.0	-1.7
Water consumed over 24 hours	0.0	0.0	0.1	-0.1	-0.1	0.2	0.0	0.2
Number of responses in last shaping day	0.0	0.0	0.1	0.1	-0.0	0.2	0.3	0.2