Hub : Genes

Fastkd5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Fastkd5 0.02 0.03 7.7e-03 0.01 0.01 0 0 2.4e-02 5.0e-02 2.1e-01 8.8e-02
2 Adipose intron excision ratio chr3_117833084_117846375 0.03 0.03 2.3e-03 0.01 0 0.01 0 2.5e-02 7.8e-02 6.6e-02 1.1e-01
3 BLA intron excision ratio chr3_117820001_117847621 0.13 0.12 2.0e-05 0.07 0.03 0.05 0.06 1.3e-04 1.5e-02 1.4e-03 4.1e-04
4 NAcc intron excision ratio chr3_117820001_117847621 0.02 0.03 7.1e-03 0.01 0.01 0.01 0.01 1.4e-02 7.1e-03 9.3e-03 1.7e-02
5 Brain intron excision ratio chr3_117820001_117847621 0.05 0.05 1.0e-04 0.04 0.04 0.04 0.04 5.2e-05 1.5e-04 1.9e-04 8.9e-05
6 PL intron excision ratio chr3_117820001_117847621 0.02 0.02 5.2e-03 0.01 0.01 0 0.01 1.1e-02 1.5e-02 2.0e-01 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.30.60.7-0.7-0.80.8-0.80.70.7
Area under the delay curve0.20.30.70.80.4-0.40.5-0.4-0.3
BMI with tail1.54.85.5-2.2-2.32.3-2.02.32.0
BMI without tail4.38.910.7-2.6-3.13.1-2.93.32.9
Body weight6.326.529.0-5.4-5.25.2-5.25.14.8
Weight adjusted by age2.83.24.3-1.7-2.02.0-2.11.21.7
Bone surface0.61.01.2-0.9-1.11.1-1.10.90.8
Bone volume0.50.91.1-1.0-1.01.0-1.00.90.8
Breakpoint value in progressive ratio session3.63.94.9-2.0-1.91.9-1.92.21.9
Number of licking bursts0.20.30.40.30.6-0.60.4-0.6-0.6
Context. condit. distance diff. score0.00.10.1-0.4-0.30.3-0.1-0.0-0.1
Locomotion velocity, session 10.20.20.4-0.0-0.60.6-0.60.30.4
Locomotion distance, session 10.20.20.4-0.1-0.70.7-0.40.40.2
Locomotion velocity, session 20.10.20.50.70.2-0.20.3-0.4-0.4
Locomotion distance, session 21.21.62.2-1.0-1.31.3-1.21.51.3
Locomotion velocity, session 31.51.72.4-1.1-1.51.5-1.21.11.2
Locomotion distance, session 37.78.49.4-2.9-3.13.1-2.72.82.8
Stereotopy head waving bouts, day 31.51.82.31.41.5-1.51.2-1.4-1.0
Stereotopy head waving duration, day 31.01.21.61.11.3-1.31.0-1.1-0.9
Locomotion velocity, session 71.01.11.6-1.3-1.01.0-0.91.01.1
Locomotion distance, session 70.70.81.1-0.7-1.01.0-0.71.10.9
Stereotopy head waving bouts, day 70.40.50.7-0.8-0.50.5-0.80.70.8
Stereotopy head waving duration, day 70.10.20.4-0.6-0.20.2-0.50.30.4
Locomotion velocity, session 80.40.41.3-1.1-0.60.6-0.60.40.3
Locomotion distance, session 81.92.83.6-1.8-1.91.9-1.51.61.3
Degree of sensitization distance2.52.52.71.61.6-1.61.6-1.4-1.5
Degree of sensitization stereotypy2.62.83.2-1.7-1.51.5-1.81.71.8
Conditioned locomotion3.74.35.1-1.6-2.22.2-2.32.02.1
Cocaine response after cond. corrected0.10.10.20.30.3-0.30.4-0.5-0.5
Cocaine response after cond. not corrected0.20.20.30.50.4-0.40.5-0.6-0.5
Cocaine response before conditioning0.10.20.30.40.5-0.50.4-0.1-0.1
Saline control response7.49.710.3-2.9-3.23.2-3.23.13.0
Bone: connectivity density0.10.20.2-0.3-0.40.4-0.50.50.4
Bone: cortical apparent density0.70.91.3-0.6-0.90.9-1.01.01.1
Bone: cortical area3.75.56.0-2.3-2.42.4-2.32.32.3
Bone: cortical porosity0.20.30.5-0.5-0.70.7-0.40.30.3
Bone: cortical porosity0.70.81.1-0.9-1.11.1-0.80.80.7
Bone: cortical thickness1.72.83.2-1.5-1.81.8-1.61.61.6
Bone: cortical thickness0.30.40.4-0.6-0.60.6-0.60.50.6
Bone: cortical tissue density0.50.71.1-0.5-0.80.8-0.90.91.0
Condit. Reinf. active minus inactive responses1.01.21.6-1.2-1.11.1-0.91.11.1
Condit. Reinf. active-inactive response ratio1.01.11.7-1.3-0.90.9-0.91.11.1
Condit. Reinf. active responses0.70.91.1-0.9-1.01.0-0.80.90.9
Condit. Reinf. inactive responses0.00.00.10.3-0.10.10.00.0-0.1
Incentive salience index mean0.70.81.1-0.8-1.11.1-0.70.80.8
Condit. Reinf. lever presses0.20.30.6-0.2-0.80.8-0.30.40.3
Condit. Reinf. active minus inactive responses2.32.94.8-1.4-1.31.3-1.72.02.2
Condit. Reinf. active-inactive response ratio2.42.53.7-1.5-1.31.3-1.61.81.9
Condit. Reinf. active responses3.54.97.5-1.9-1.81.8-2.32.62.7
Condit. Reinf. inactive responses0.50.60.8-0.7-0.60.6-0.90.90.9
Condit. Reinf. lever presses1.31.82.5-1.2-1.01.0-1.51.61.6
Condit. Reinf. lever reinforcers received2.63.75.8-1.6-1.51.5-2.02.32.4
Conditioned reinforcement - actives0.00.00.00.10.0-0.0-0.1-0.0-0.0
Conditioned reinforcement - inactives0.30.30.6-0.3-0.30.3-0.60.80.8
Conditioned locomotion0.00.10.1-0.00.3-0.30.30.0-0.2
Patch foraging indifference point 0 sec0.00.00.1-0.10.0-0.0-0.30.20.2
Patch foraging indifference point AUC0.70.80.9-0.8-0.90.9-0.81.00.8
Delay disc. indifference point, 0s delay2.02.23.01.31.7-1.71.7-1.4-1.2
Delay disc. indifference point, 16s delay0.70.71.71.30.6-0.60.9-0.7-0.7
Delay disc. indifference point, 2s delay0.00.00.00.10.1-0.10.1-0.2-0.2
Delay disc. indifference point, 24s delay2.92.84.22.01.4-1.41.6-1.8-1.7
Delay disc. indifference point, 4s delay0.10.10.3-0.2-0.20.2-0.20.50.5
Delay disc. indifference point, 8s delay0.30.30.80.90.5-0.50.5-0.4-0.3
Indifference point function ln k0.00.10.1-0.1-0.40.4-0.3-0.00.1
Indifference point function log k0.00.10.1-0.1-0.40.4-0.3-0.00.1
Patch foraging total patch changes 0 sec0.00.00.1-0.2-0.10.1-0.30.20.2
Patch foraging total patch changes 12 sec0.30.40.6-0.6-0.80.8-0.80.60.4
Patch foraging total patch changes 18 sec0.81.01.50.81.0-1.00.9-0.9-1.2
Patch foraging total patch changes 24 sec1.62.02.71.21.5-1.51.3-1.4-1.6
Patch foraging total patch changes 6 sec0.50.71.3-1.0-0.60.6-0.81.10.8
Patch foraging time to switch 0 sec1.82.83.41.61.6-1.61.7-1.7-1.8
Patch foraging water rate 0 sec3.75.97.2-2.5-2.22.2-2.52.42.7
Patch foraging water rate 12 sec0.00.10.2-0.40.0-0.0-0.1-0.3-0.2
Patch foraging water rate 18 sec0.40.51.1-1.0-0.60.6-0.70.40.7
Patch foraging water rate 24 sec0.40.50.7-0.8-0.70.7-0.90.50.7
Patch foraging water rate 6 sec1.72.53.6-1.9-1.51.5-1.81.31.5
Seeking ratio, delayed vs. immediate footshock0.40.40.80.50.5-0.50.5-0.9-0.8
Distance traveled before self-admin5.35.67.4-2.7-2.32.3-2.42.42.1
Distance traveled after self-admin3.43.75.7-2.4-1.81.8-1.82.11.7
Extensor digitorum longus weight0.10.31.1-1.0-0.40.4-0.50.40.4
Bone: elastic displacement0.00.00.10.0-0.10.1-0.00.30.4
Bone: elastic work0.10.10.2-0.5-0.20.2-0.20.40.3
Bone: endosteal estimation0.51.11.8-1.3-1.11.1-1.10.90.9
Bone: endosteal perimeter2.34.85.5-2.3-2.22.2-2.22.12.1
Epididymis fat weight1.33.13.8-1.9-1.91.9-1.81.51.3
Delta time in closed arm before/after self-admin0.20.20.30.50.5-0.50.50.00.0
Delta time in open arm before/after self-admin0.80.72.7-1.6-0.80.8-0.80.0-0.0
Diff in mean of infusions in LGA sessions0.00.00.10.10.0-0.00.10.30.0
Delay discount exponential model param0.20.20.7-0.8-0.30.3-0.50.30.3
Extinction: sum of active levers before priming1.01.01.8-1.1-0.70.7-0.91.31.1
Active lever presses in extinction session 60.10.10.10.30.3-0.30.30.0-0.3
Bone: final force3.75.96.6-2.1-2.62.6-2.52.42.4
Bone: final moment2.94.75.3-2.0-2.32.3-2.22.12.1
Food consumed during 24 hour testing period1.01.21.51.01.2-1.21.0-1.0-1.0
Glucose0.60.81.4-1.2-0.70.7-0.71.10.9
Heart weight3.14.45.1-1.9-2.32.3-2.11.82.1
Delay discount hyperbolic model param0.20.20.5-0.7-0.30.3-0.40.30.2
Intermittent access intake day 1-15 change0.60.51.2-1.1-0.70.7-0.70.60.5
Intermittent access intake escalation0.10.10.3-0.5-0.20.2-0.40.40.4
Intermittent access intake escalation 20.10.10.30.00.4-0.40.4-0.3-0.5
Intermitt. access day 1 inactive lever presses0.30.30.60.40.8-0.80.5-0.10.2
Intermitt. access day 15 inactive lever presses0.10.10.40.00.2-0.20.10.70.4
Intermitt. access escalation Index0.00.00.0-0.1-0.10.1-0.0-0.1-0.0
Intermittent access day 1 total infusions0.00.00.20.20.0-0.00.3-0.0-0.4
Intermittent access day 15 total infusions0.00.00.1-0.3-0.10.1-0.10.30.1
Intermittent access terminal intake (last 3 days)0.00.00.1-0.2-0.10.10.00.30.1
Intermittent access total infusions0.00.00.00.0-0.00.00.10.1-0.1
Intermittent access day 1 locomotion0.20.20.30.60.5-0.50.4-0.1-0.2
Intermittent access day 15 total locomotion0.10.10.10.20.3-0.30.3-0.0-0.2
Intermittent access total locomotion0.10.10.20.20.3-0.30.3-0.2-0.4
Intermittent access standard deviation0.20.20.6-0.3-0.20.2-0.30.70.7
Left kidney weight1.13.03.4-1.8-1.81.8-1.61.71.6
Right kidney weight1.02.94.4-1.5-1.61.6-1.62.11.8
Cocaine induced anxiety4.95.77.42.62.7-2.72.5-1.9-1.7
Post-drug Anxiety1.61.82.71.61.6-1.61.4-0.8-0.5
Baseline Anxiety0.50.50.8-0.9-0.80.8-0.80.40.4
Tail length5.115.516.1-3.8-4.04.0-4.04.03.8
Length with tail4.616.718.5-4.3-4.24.2-4.23.83.8
Length without tail1.32.84.6-2.1-1.61.6-1.71.31.5
Times rat made contact with spout0.10.10.20.10.4-0.40.1-0.3-0.2
Lifetime Intake0.20.20.4-0.6-0.50.5-0.40.60.3
Liver weight, left0.00.00.1-0.10.3-0.30.30.1-0.0
Liver weight, right0.10.20.3-0.3-0.40.4-0.20.50.3
Locomotor activity0.10.20.3-0.0-0.40.4-0.50.40.5
Locomotor testing distance0.10.20.40.60.6-0.60.4-0.3-0.1
Locomotor testing rearing0.10.20.60.0-0.20.2-0.50.60.8
Locomotion in novel chamber0.10.10.20.50.4-0.40.4-0.40.0
Locomotion in novel chamber post-restriction1.11.32.6-1.0-0.90.9-1.11.11.6
Fecal boli incidents, locomotor time 10.10.10.2-0.4-0.30.3-0.30.30.4
Change in fecal boli incidents, locomotor task0.20.20.40.40.3-0.30.3-0.6-0.5
Time >=10cm from walls, locomotor time 10.10.10.3-0.3-0.30.3-0.30.50.2
Bouts of movement, locomotor time 11.82.02.21.51.4-1.41.5-1.2-1.4
Total resting periods, locomotor time 11.41.61.91.41.3-1.31.3-1.1-1.2
Rest time, locomotor task time 10.30.30.40.60.5-0.50.5-0.5-0.6
Distance moved, locomotor task time 10.10.10.2-0.4-0.20.2-0.10.40.4
Vertical activity count, locomotor time 10.20.20.3-0.5-0.60.6-0.30.40.4
Time >=10cm from walls, locomotor time 20.00.00.0-0.2-0.10.10.10.1-0.0
Bouts of movement, locomotor time 20.40.40.70.30.6-0.60.7-0.6-0.8
Total resting periods, locomotor time 20.40.40.60.30.7-0.70.7-0.5-0.8
Rest time, locomotor task time 20.60.71.30.81.1-1.10.6-0.5-0.5
Distance moved, locomotor task time 20.00.00.10.0-0.30.30.1-0.0-0.0
Vertical activity count, locomotor time 20.30.30.4-0.3-0.70.7-0.30.60.6
Light reinforcement 10.91.62.3-0.8-1.11.1-1.31.51.5
Light reinforcement 20.60.81.3-0.7-0.80.8-0.91.11.1
Bone: marrow area0.51.01.7-1.3-1.01.0-1.00.90.8
Bone: maximum diameter4.68.58.8-2.9-3.03.0-3.02.82.8
Bone: maximum force0.61.01.3-0.8-1.11.1-1.11.01.0
Bone: maximum moment0.20.40.5-0.6-0.70.7-0.70.60.6
Mean time between licks in bursts0.10.20.8-0.9-0.40.4-0.0-0.10.0
Mean num. licks in bursts0.10.10.2-0.1-0.30.3-0.30.40.4
Cd content in liver0.10.10.20.40.1-0.10.4-0.0-0.0
Co content in liver0.80.91.0-0.9-0.90.9-0.91.01.0
Cu content in liver1.72.02.5-1.4-1.41.4-1.61.31.3
Fe content in liver0.00.00.1-0.20.1-0.10.0-0.0-0.1
K content in liver0.20.20.3-0.3-0.50.5-0.60.30.3
Mg content in liver1.51.51.8-1.2-1.31.3-1.31.21.2
Mn content in liver1.82.12.4-0.9-1.61.6-1.51.51.5
Na content in liver0.10.10.20.40.1-0.10.2-0.4-0.5
Rb content in liver3.84.77.6-2.7-2.22.2-2.11.91.9
Se content in liver0.50.61.0-0.6-0.80.8-1.00.80.8
Sr content in liver0.90.81.2-0.8-0.90.9-0.71.11.1
Zn content in liver0.30.30.4-0.2-0.60.6-0.50.50.5
Bone: minimum diameter1.83.44.3-2.1-1.91.9-1.81.61.6
Time in familiar zone, hab. session 11.41.31.50.81.2-1.21.2-1.2-1.2
Time in novel zone, hab. session 10.40.40.5-0.3-0.70.7-0.70.60.6
Total zone transitions, hab. session 10.20.20.50.1-0.70.7-0.30.50.3
Total locomotion distance, hab. session 10.00.10.20.4-0.20.20.00.20.1
Locomotion velocity, hab. session 10.10.10.20.4-0.40.4-0.10.40.3
Time in familiar zone, hab. session 21.51.61.81.21.3-1.31.4-1.2-1.1
Time in novel zone, hab. session 21.51.51.9-1.2-1.31.3-1.41.11.1
Total zone transitions, hab. session 22.63.44.7-1.3-2.22.2-1.81.81.7
Total locomotion distance, hab. session 20.60.81.2-0.2-1.11.1-0.80.90.9
Locomotion velocity, hab. session 20.20.30.60.2-0.80.8-0.40.60.5
Novel to familiar place preference ratio0.20.20.30.10.5-0.50.4-0.3-0.5
Novelty place preference0.40.40.50.30.7-0.70.6-0.5-0.7
Time in novel zone, NPP test0.20.20.30.10.5-0.50.4-0.3-0.5
Total zone transitions, NPP test0.20.30.60.3-0.80.8-0.30.40.3
Total locomotion distance, NPP test0.20.20.40.3-0.70.7-0.30.40.4
Locomotion velocity, NPP test0.10.10.50.7-0.30.30.00.0-0.0
Intraocular pressure0.00.00.0-0.10.1-0.1-0.20.1-0.1
Delta distance traveled before/after self-admin0.20.20.2-0.5-0.40.4-0.50.50.4
Delta ambulatory time before/after self-admin0.40.40.60.70.6-0.60.7-0.4-0.6
Parametrial fat weight0.10.20.50.5-0.10.10.4-0.7-0.5
Pavlov. Cond. lever latency0.10.20.4-0.30.0-0.0-0.50.40.6
Pavlov. Cond. magazine entry latency0.10.10.2-0.2-0.30.3-0.20.40.4
Pavlov. Cond. change in total contacts0.10.10.1-0.2-0.40.4-0.20.10.1
Pavlov. Cond. index score0.00.00.1-0.1-0.30.30.00.1-0.0
Pavlov. Cond. latency score0.00.00.10.2-0.10.10.3-0.2-0.3
Pavlov. Cond. lever contacts0.10.20.4-0.2-0.60.6-0.20.30.1
Pavlov. Cond. magazine entry number0.70.91.00.90.9-0.90.9-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.6-0.20.2-0.30.30.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.20.20.10.1-0.0
Pavlov. Cond. response bias0.60.70.8-0.8-0.90.9-0.70.90.8
Pavlov. Cond. lever latency3.95.36.52.12.1-2.12.4-2.6-2.5
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.20.2-0.30.20.3
Pavlov. Cond. change in total contacts3.75.15.8-2.2-2.12.1-2.42.32.4
Pavlov. Cond. index score3.44.34.7-2.1-2.02.0-2.12.12.2
Pavlov. Cond. latency score2.63.33.9-1.8-1.71.7-1.81.92.0
Pavlov. Cond. lever contacts3.95.36.4-2.3-2.02.0-2.42.52.4
Pavlov. Cond. magazine entry number0.60.71.01.00.7-0.70.9-0.9-1.0
Pavlov. Cond. intertrial magazine entries1.11.42.11.50.9-0.91.2-1.2-1.3
Pavlov. Cond. lever-magazine prob. diff.3.03.84.1-2.0-1.81.8-2.02.02.0
Pavlov. Cond. response bias4.15.66.3-2.5-2.12.1-2.52.52.5
Time in closed arm before self-admin0.20.20.60.20.3-0.30.5-0.8-0.6
Time in closed arm after self-admin0.30.30.70.50.5-0.50.8-0.5-0.5
Time in open arm before self-admin0.40.41.71.30.4-0.40.40.40.2
Time in open arm after self-admin0.00.00.1-0.3-0.10.1-0.3-0.1-0.1
Bone: periosteal estimation2.55.25.9-2.4-2.32.3-2.32.12.1
Bone: periosteal perimeter3.86.38.2-2.9-2.52.5-2.42.32.3
Bone: post-yield work0.81.11.40.91.2-1.20.9-1.0-0.9
Progressive ratio test 1 active lever presses2.83.03.6-1.7-1.91.9-1.71.71.4
Progressive ratio test 1 breakpoint3.73.84.6-2.0-2.12.1-1.92.01.6
Progressive ratio test 1 inactive lever presses0.30.30.7-0.5-0.30.3-0.50.80.8
Progressive ratio test 2 active lever presses0.30.30.5-0.6-0.70.7-0.40.50.1
Progressive ratio test 2 breakpoint0.20.30.5-0.5-0.70.7-0.40.4-0.0
Progressive ratio test 2 inactive lever presses0.20.30.8-0.2-0.20.2-0.30.90.8
Incentive Sensitization - Responses0.30.30.7-0.8-0.70.7-0.40.40.0
Incentive Sensitization - Breakpoint0.20.20.4-0.7-0.50.5-0.20.2-0.2
Sum of active levers in priming session hrs 5-61.01.01.3-0.8-0.90.9-1.11.01.1
Progressive ratio3.03.44.32.11.9-1.91.8-1.7-1.6
Food seeking constrained by brief footshock0.40.51.0-0.4-0.60.6-0.50.81.0
Seeking ratio, punishment vs. effort3.23.94.2-2.1-2.02.0-1.81.91.9
Retroperitoneal fat weight0.00.10.30.1-0.40.40.1-0.4-0.5
Reaction time number correct0.10.20.4-0.4-0.30.3-0.60.30.6
Reaction time mean minus median0.91.21.41.21.2-1.21.0-1.0-1.1
Reaction time mean minus median AUC0.70.91.11.01.0-1.00.8-0.9-0.9
Reaction time num false alarms2.02.73.3-1.4-1.81.8-1.61.61.5
Reaction time num false alarms AUC2.12.93.6-1.5-1.91.9-1.71.61.5
Reaction time trials correct on left0.10.20.4-0.4-0.30.3-0.60.30.6
Reaction time trials on left0.20.20.5-0.4-0.40.4-0.70.40.7
Reaction time mean0.00.00.1-0.00.2-0.20.1-0.0-0.3
Reaction time mean AUC0.00.00.10.00.3-0.30.2-0.0-0.3
Median of all reaction times0.00.00.1-0.4-0.10.1-0.20.1-0.1
Reaction time omissions0.40.51.0-0.4-0.50.5-0.71.01.0
Reaction time false alarm rate1.21.62.2-1.1-1.51.5-1.21.31.1
Reaction time premature initiation rate0.30.40.60.60.6-0.60.5-0.8-0.6
Reaction time premature initiations0.20.20.50.60.5-0.50.3-0.7-0.4
Std. dev. reaction times0.00.10.1-0.1-0.20.2-0.30.30.2
Reaction time trials completed0.20.20.5-0.4-0.40.4-0.70.40.7
Reaction time trials AUC0.20.30.5-0.5-0.40.4-0.70.40.7
Run reversals in cocaine runway, females0.00.00.00.10.2-0.20.00.00.2
Run reversals in cocaine runway, males1.31.32.2-1.1-0.90.9-0.91.51.4
Latency to leave start box in cocaine runway0.40.50.80.90.4-0.40.8-0.5-0.8
Latency to leave start box in cocaine runway, F0.91.01.51.21.0-1.01.2-0.6-1.0
Latency to leave start box in cocaine runway, M0.10.10.1-0.1-0.30.3-0.30.20.0
Std. dev. time between licks in bursts0.60.81.3-1.1-1.01.0-0.70.50.6
Total sessions with >9 infusions0.60.71.1-1.1-0.90.9-0.70.80.5
Short access day 1 total inactive lever presses0.60.71.11.10.9-0.90.9-0.6-0.6
Short access day 10 total inactive lever presses3.13.54.71.82.2-2.22.1-1.4-1.4
Short access day 1 total infusions0.10.10.3-0.5-0.30.3-0.10.30.1
Short access day 10 total infusions0.10.10.5-0.2-0.30.3-0.10.70.3
Short access total infusions0.50.51.1-1.0-0.80.8-0.60.70.3
Short access day 1 locomotion0.80.81.10.30.9-0.91.0-1.0-1.0
Short access day 10 total locomotion0.00.00.1-0.30.1-0.1-0.10.1-0.0
Short access total locomotion0.00.00.1-0.30.1-0.1-0.00.20.2
One hour access (0.3 mA shock)0.10.10.20.10.2-0.20.2-0.3-0.5
Compulsive drug intake4.74.75.72.42.2-2.22.1-2.1-2.1
One hour access (shock baseline)0.40.51.0-1.0-0.60.6-0.70.60.5
Social response proportion1.31.41.9-1.0-1.01.0-1.31.41.3
Social responses4.76.07.0-2.0-2.42.4-2.62.62.6
Social time0.40.50.7-0.5-0.70.7-0.80.60.7
Soleus weight0.00.00.2-0.4-0.10.1-0.20.1-0.0
Bone: stiffness1.82.83.2-1.4-1.81.8-1.81.61.6
Tibialis anterior weight0.82.93.4-1.9-1.61.6-1.71.71.7
Time to tail flick, vehicle, before self-admin2.62.63.91.21.5-1.51.5-2.0-1.9
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1-0.10.1-0.0-0.0-0.0
Time to tail flick, test, before self-admin0.80.81.1-0.6-1.01.0-1.00.51.0
Time to tail flick, test, after self-admin2.22.32.51.41.6-1.61.6-1.6-1.4
Delta time to tail flick, vehicle, before/after SA4.64.56.7-1.5-2.02.0-1.92.62.6
Delta time to tail flick, test, before/after SA3.12.83.51.31.9-1.91.6-1.6-1.6
Tibia length4.913.718.1-4.3-3.63.6-3.73.63.5
Ambulatory time before self-admin4.44.55.5-2.4-2.22.2-2.22.11.8
Ambulatory time after self-admin4.24.67.0-2.6-2.12.1-2.12.21.7
Bone: tissue strength0.10.10.1-0.0-0.30.3-0.40.30.3
Total heroin consumption3.64.25.2-1.8-2.02.0-2.12.32.2
Bone: trabecular number0.60.91.0-0.8-1.01.0-1.00.90.9
Bone: trabecular spacing0.10.20.40.60.5-0.50.4-0.1-0.1
Bone: trabecular thickness0.40.51.0-1.0-0.80.8-0.70.50.5
Bone: trabecular tissue density1.41.92.5-1.0-1.61.6-1.41.31.3
Water consumed over 24 hours0.20.30.60.40.8-0.80.3-0.4-0.4
Number of responses in last shaping day0.20.20.30.20.6-0.60.5-0.10.1