Hub : Genes

Fasn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Fasn 0.06 0.04 1.7e-05 0.03 0.04 0.04 0.04 8.3e-04 1.0e-05 1.7e-05 9.1e-05
2 Liver mRNA stability Fasn 0.03 0.02 6.8e-03 0.02 0.01 0.01 0.01 5.7e-03 4.8e-02 9.9e-03 1.5e-02
3 NAcc gene expression Fasn 0.05 0.03 2.9e-08 0.03 0.06 0.05 0.05 1.3e-05 6.5e-09 1.1e-08 1.9e-08
4 IC gene expression Fasn 0.08 0.05 4.6e-03 0.02 0.06 0.05 0.06 3.4e-02 2.2e-03 4.8e-03 2.3e-03
5 Adipose gene expression Fasn 0.03 0.02 2.0e-04 0.01 0.02 0 0.01 1.2e-02 3.3e-03 8.5e-02 2.1e-02
6 Brain gene expression Fasn 0.04 0.03 2.6e-04 0.04 0.04 0.03 0.04 1.3e-04 1.6e-04 1.3e-03 2.5e-04
7 Adipose mRNA stability Fasn 0.06 0.03 9.1e-08 0.07 0.07 0.06 0.07 3.9e-08 8.6e-08 1.4e-07 8.7e-08
8 pVTA gene expression Fasn 0.12 0.1 1.2e-05 0.11 0.06 0.09 0.1 6.3e-09 1.8e-05 1.1e-07 3.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.30.6-0.40.6-0.3-0.40.70.20.8-0.4
Area under the delay curve1.61.92.11.4-1.41.51.4-1.31.1-1.41.4
BMI with tail0.51.73.7-1.71.9-1.3-1.11.0-0.80.81.3
BMI without tail2.36.912.6-2.83.6-2.5-2.73.1-1.12.9-1.1
Body weight2.310.116.7-4.13.9-3.7-3.53.1-2.32.80.0
Weight adjusted by age1.92.83.6-1.91.8-1.9-1.81.6-1.81.6-1.0
Bone surface0.30.51.6-0.40.4-0.5-0.60.7-0.30.9-1.2
Bone volume0.30.51.1-0.50.6-0.5-0.60.8-0.21.0-1.1
Breakpoint value in progressive ratio session0.81.03.2-1.20.3-1.4-1.10.3-1.80.10.2
Number of licking bursts0.10.10.30.00.20.1-0.00.50.50.5-0.4
Context. condit. distance diff. score0.60.71.7-0.10.90.1-0.31.31.01.1-1.1
Locomotion velocity, session 11.51.63.91.0-1.50.91.1-2.0-0.4-1.41.3
Locomotion distance, session 13.13.96.01.9-1.42.12.1-1.72.1-1.82.4
Locomotion velocity, session 24.14.86.52.3-2.32.22.3-2.51.2-2.42.0
Locomotion distance, session 20.60.92.60.7-0.21.00.9-0.51.3-0.61.6
Locomotion velocity, session 31.92.23.51.3-1.71.21.4-1.90.6-1.71.7
Locomotion distance, session 33.94.35.71.9-2.11.92.1-2.21.4-2.32.4
Stereotopy head waving bouts, day 30.50.61.20.5-0.80.50.7-1.1-0.1-0.91.1
Stereotopy head waving duration, day 30.40.51.00.6-0.60.60.7-0.90.2-0.91.0
Locomotion velocity, session 70.91.01.61.3-1.21.11.1-0.81.1-0.90.2
Locomotion distance, session 73.14.06.02.4-1.82.52.3-1.42.4-1.51.1
Stereotopy head waving bouts, day 70.30.30.5-0.70.6-0.6-0.60.4-0.60.4-0.0
Stereotopy head waving duration, day 70.20.30.4-0.70.6-0.6-0.60.5-0.50.5-0.2
Locomotion velocity, session 80.80.92.20.8-0.21.11.0-0.41.5-0.61.4
Locomotion distance, session 80.60.94.40.40.80.80.41.02.10.50.4
Degree of sensitization distance0.90.92.7-0.40.9-0.3-0.61.30.11.2-1.7
Degree of sensitization stereotypy0.30.40.6-0.70.8-0.6-0.60.7-0.30.6-0.1
Conditioned locomotion3.64.26.9-1.92.4-1.7-2.02.6-0.62.4-1.8
Cocaine response after cond. corrected0.20.20.7-0.1-0.3-0.10.0-0.5-0.4-0.50.9
Cocaine response after cond. not corrected0.60.71.70.5-0.90.50.6-1.00.3-1.11.3
Cocaine response before conditioning1.21.52.81.4-1.01.41.3-0.81.7-1.20.8
Saline control response2.33.14.7-1.72.0-1.6-1.82.2-0.72.0-1.8
Bone: connectivity density0.10.20.70.40.10.50.20.40.80.4-0.6
Bone: cortical apparent density2.53.44.72.0-2.21.92.0-2.11.1-1.91.4
Bone: cortical area5.38.215.0-3.93.6-3.5-3.12.2-2.32.01.2
Bone: cortical porosity1.11.23.9-1.30.4-1.6-1.2-0.1-2.00.2-0.0
Bone: cortical porosity1.61.74.2-1.60.8-1.8-1.50.4-2.00.6-0.4
Bone: cortical thickness5.38.917.2-4.13.4-3.7-3.11.6-2.81.72.3
Bone: cortical thickness1.72.03.9-2.01.5-1.7-1.30.6-1.30.41.8
Bone: cortical tissue density2.73.75.52.1-2.32.02.1-2.21.1-1.91.3
Condit. Reinf. active minus inactive responses2.32.63.6-1.91.9-1.7-1.71.8-0.91.8-0.9
Condit. Reinf. active-inactive response ratio0.80.91.6-1.31.1-1.1-1.11.0-0.40.90.1
Condit. Reinf. active responses4.35.47.4-2.52.7-2.2-2.42.6-1.32.7-1.7
Condit. Reinf. inactive responses1.51.82.8-1.11.5-1.0-1.31.5-0.81.7-1.6
Incentive salience index mean1.72.13.0-1.61.7-1.4-1.51.7-0.61.7-1.0
Condit. Reinf. lever presses0.10.10.50.20.10.30.10.40.70.3-0.3
Condit. Reinf. active minus inactive responses0.60.71.3-1.11.1-0.8-0.80.8-0.40.80.7
Condit. Reinf. active-inactive response ratio2.12.44.1-2.01.7-1.8-1.81.3-1.51.4-0.2
Condit. Reinf. active responses0.10.20.6-0.40.6-0.1-0.20.40.30.40.8
Condit. Reinf. inactive responses0.81.01.51.0-0.81.11.1-0.81.2-0.81.1
Condit. Reinf. lever presses0.20.20.5-0.30.6-0.1-0.30.70.50.70.0
Condit. Reinf. lever reinforcers received0.10.20.4-0.40.6-0.1-0.20.50.40.50.6
Conditioned reinforcement - actives0.20.31.00.50.20.50.5-0.31.0-0.40.8
Conditioned reinforcement - inactives0.20.30.4-0.60.5-0.6-0.60.6-0.40.5-0.2
Conditioned locomotion0.10.10.30.20.60.20.20.00.30.2-0.0
Patch foraging indifference point 0 sec0.10.10.3-0.20.1-0.3-0.30.40.20.5-0.6
Patch foraging indifference point AUC0.10.10.4-0.00.30.0-0.10.40.10.5-0.7
Delay disc. indifference point, 0s delay0.10.10.9-0.00.10.10.2-0.2-0.0-0.21.0
Delay disc. indifference point, 16s delay1.92.13.71.7-0.91.81.6-0.91.9-1.11.1
Delay disc. indifference point, 2s delay0.40.50.70.6-0.90.60.7-0.80.2-0.80.7
Delay disc. indifference point, 24s delay4.24.87.22.2-2.72.12.3-2.70.5-2.41.8
Delay disc. indifference point, 4s delay0.40.41.30.4-0.50.50.5-0.60.3-0.81.1
Delay disc. indifference point, 8s delay0.80.91.50.6-1.20.70.8-1.10.4-1.11.2
Indifference point function ln k1.01.73.01.1-1.01.11.3-1.21.3-1.51.7
Indifference point function log k1.01.73.01.1-1.01.11.3-1.21.3-1.51.7
Patch foraging total patch changes 0 sec0.10.10.3-0.30.2-0.3-0.30.50.30.5-0.4
Patch foraging total patch changes 12 sec0.30.41.2-0.40.3-0.4-0.50.4-0.70.8-1.1
Patch foraging total patch changes 18 sec0.10.10.60.30.20.40.20.20.80.3-0.2
Patch foraging total patch changes 24 sec0.50.81.1-1.01.0-0.9-1.01.0-0.51.0-0.6
Patch foraging total patch changes 6 sec0.40.60.9-0.80.6-0.8-0.90.7-0.50.9-0.8
Patch foraging time to switch 0 sec0.30.61.01.0-1.00.90.9-0.80.3-0.70.1
Patch foraging water rate 0 sec1.32.74.1-1.92.0-1.7-1.82.0-0.51.6-0.6
Patch foraging water rate 12 sec0.20.51.5-0.71.2-0.3-0.30.70.40.31.0
Patch foraging water rate 18 sec0.40.72.3-0.81.5-0.5-0.51.00.50.60.5
Patch foraging water rate 24 sec1.52.15.6-1.52.4-1.1-1.31.9-0.01.50.0
Patch foraging water rate 6 sec0.40.63.1-0.50.9-0.2-0.10.20.4-0.11.8
Seeking ratio, delayed vs. immediate footshock1.21.52.1-1.31.5-1.2-1.31.4-1.11.3-0.6
Distance traveled before self-admin0.91.12.1-1.30.5-1.5-1.30.8-1.40.8-0.4
Distance traveled after self-admin1.01.24.8-0.50.6-0.6-0.81.4-0.21.1-2.2
Extensor digitorum longus weight0.10.41.0-0.11.00.1-0.10.90.90.70.1
Bone: elastic displacement1.31.52.3-1.51.3-1.5-1.40.9-1.21.0-0.3
Bone: elastic work7.49.616.1-4.03.2-4.0-3.52.1-3.62.3-0.5
Bone: endosteal estimation0.10.30.80.60.10.60.30.40.80.2-0.9
Bone: endosteal perimeter0.61.32.7-0.91.1-1.1-1.21.2-0.81.1-1.6
Epididymis fat weight0.92.95.1-1.92.3-1.8-1.82.2-0.11.7-0.6
Delta time in closed arm before/after self-admin0.80.84.60.7-0.10.80.60.22.1-0.20.1
Delta time in open arm before/after self-admin0.10.10.20.2-0.20.00.2-0.2-0.5-0.1-0.3
Diff in mean of infusions in LGA sessions0.20.20.6-0.2-0.2-0.5-0.40.2-0.6-0.1-0.8
Delay discount exponential model param2.22.53.0-1.61.7-1.6-1.61.7-1.11.7-1.6
Extinction: sum of active levers before priming0.60.71.40.4-0.60.40.7-1.2-0.7-1.01.1
Active lever presses in extinction session 61.61.64.5-0.2-1.1-0.30.2-1.5-1.6-1.42.1
Bone: final force5.68.915.8-4.03.9-3.5-3.22.6-2.22.40.8
Bone: final moment6.510.518.2-4.34.0-3.9-3.52.7-2.62.60.5
Food consumed during 24 hour testing period0.40.51.1-0.50.4-0.6-0.70.9-0.20.9-1.0
Glucose5.28.117.61.8-3.71.42.1-4.2-1.0-3.73.1
Heart weight1.11.73.4-1.71.5-1.6-1.30.6-1.80.90.4
Delay discount hyperbolic model param2.02.22.7-1.51.6-1.5-1.51.6-0.91.6-1.5
Intermittent access intake day 1-15 change0.71.43.1-0.91.6-1.1-1.20.8-0.91.0-1.8
Intermittent access intake escalation0.61.32.6-0.81.6-1.0-1.10.8-0.81.0-1.6
Intermittent access intake escalation 22.22.53.3-1.51.8-1.8-1.71.0-1.81.1-1.7
Intermitt. access day 1 inactive lever presses0.83.26.1-1.62.5-1.4-1.82.20.12.0-1.6
Intermitt. access day 15 inactive lever presses0.40.91.9-0.61.4-0.5-0.71.2-0.11.2-1.0
Intermitt. access escalation Index0.40.61.1-0.21.0-0.2-0.41.00.70.8-1.1
Intermittent access day 1 total infusions0.10.20.4-0.40.6-0.3-0.20.2-0.20.30.7
Intermittent access day 15 total infusions0.60.92.9-0.81.7-0.8-0.80.8-0.41.0-0.7
Intermittent access terminal intake (last 3 days)0.91.22.4-0.91.6-1.0-1.11.0-0.61.2-1.1
Intermittent access total infusions0.30.31.1-0.51.1-0.5-0.50.50.00.6-0.1
Intermittent access day 1 locomotion0.20.31.3-0.00.40.10.2-0.10.8-0.21.1
Intermittent access day 15 total locomotion0.40.71.9-0.81.4-0.8-0.80.7-0.40.9-0.5
Intermittent access total locomotion0.20.31.0-0.51.0-0.4-0.40.30.20.40.3
Intermittent access standard deviation0.20.41.00.10.4-0.10.2-1.0-0.7-0.90.8
Left kidney weight0.10.62.3-0.80.5-0.7-0.4-0.3-1.0-0.01.5
Right kidney weight0.20.74.3-0.70.3-0.5-0.1-0.5-0.7-0.32.1
Cocaine induced anxiety1.62.36.8-1.90.3-2.0-1.50.0-2.6-0.21.3
Post-drug Anxiety1.11.23.0-0.9-0.8-0.9-0.5-0.9-1.7-0.81.7
Baseline Anxiety1.31.52.41.5-1.51.51.4-1.11.3-0.70.2
Tail length3.011.815.9-3.53.6-3.5-3.84.0-1.93.8-2.8
Length with tail1.46.110.6-3.22.3-3.3-3.02.2-2.12.0-0.5
Length without tail0.61.83.6-1.70.2-1.8-1.1-0.4-1.9-0.51.8
Times rat made contact with spout2.32.78.4-1.00.4-1.3-1.51.0-1.81.9-2.9
Lifetime Intake0.10.10.6-0.10.8-0.1-0.10.10.20.20.2
Liver weight, left1.01.74.70.9-1.40.81.0-1.30.7-1.62.2
Liver weight, right1.52.54.3-1.81.9-1.7-1.82.1-0.61.6-0.2
Locomotor activity0.60.91.21.1-1.11.01.1-1.10.5-1.00.6
Locomotor testing distance1.62.83.41.8-1.61.81.8-1.51.7-1.71.2
Locomotor testing rearing0.50.91.71.3-0.91.21.1-0.51.2-0.6-0.3
Locomotion in novel chamber0.40.50.80.8-0.60.80.8-0.40.9-0.60.4
Locomotion in novel chamber post-restriction2.94.86.0-2.12.1-2.1-2.42.5-1.42.4-2.3
Fecal boli incidents, locomotor time 10.30.40.80.9-0.40.90.8-0.50.5-0.30.1
Change in fecal boli incidents, locomotor task1.21.22.60.8-1.60.60.8-1.5-0.6-1.40.7
Time >=10cm from walls, locomotor time 10.80.92.0-0.41.1-0.3-0.61.4-0.11.4-1.2
Bouts of movement, locomotor time 11.31.52.51.3-1.31.21.3-1.5-0.0-1.60.9
Total resting periods, locomotor time 11.61.82.91.4-1.61.21.4-1.70.0-1.71.0
Rest time, locomotor task time 10.40.50.90.5-1.00.30.4-0.9-0.7-1.00.4
Distance moved, locomotor task time 10.20.40.6-0.60.7-0.5-0.50.80.60.7-0.4
Vertical activity count, locomotor time 10.30.81.6-0.81.2-0.7-0.81.30.11.0-0.6
Time >=10cm from walls, locomotor time 20.20.30.9-0.40.6-0.3-0.20.1-1.00.60.4
Bouts of movement, locomotor time 20.91.51.81.2-1.21.21.2-1.01.1-1.31.3
Total resting periods, locomotor time 20.61.11.71.0-0.91.21.1-0.71.3-1.01.0
Rest time, locomotor task time 20.20.20.50.5-0.50.30.2-0.00.7-0.5-0.6
Distance moved, locomotor task time 20.10.10.8-0.30.3-0.10.0-0.1-0.10.10.9
Vertical activity count, locomotor time 20.10.21.0-0.20.70.00.10.1-0.10.21.0
Light reinforcement 10.61.43.4-0.81.4-0.7-0.91.80.31.4-1.4
Light reinforcement 21.32.03.6-1.41.7-1.4-1.41.9-0.31.4-1.1
Bone: marrow area0.10.30.70.50.10.60.30.40.80.2-0.8
Bone: maximum diameter1.12.13.8-1.91.9-1.8-1.61.2-1.11.00.4
Bone: maximum force5.39.416.3-4.04.0-3.5-3.32.7-2.22.60.7
Bone: maximum moment6.110.618.2-4.34.2-3.8-3.52.8-2.62.70.4
Mean time between licks in bursts0.92.22.61.6-1.41.61.6-1.51.3-1.51.3
Mean num. licks in bursts0.50.71.8-0.60.1-0.8-0.80.3-1.30.6-1.3
Cd content in liver0.40.51.20.9-0.21.00.8-0.11.1-0.20.0
Co content in liver0.10.10.70.1-0.0-0.1-0.10.2-0.10.3-0.9
Cu content in liver0.91.01.7-1.10.8-1.3-1.20.7-1.10.8-1.0
Fe content in liver0.70.81.51.0-0.81.01.0-0.61.2-0.90.5
K content in liver1.11.12.7-0.40.9-0.3-0.71.61.01.2-1.4
Mg content in liver0.90.92.40.40.60.50.11.21.51.0-1.3
Mn content in liver0.10.10.2-0.30.4-0.2-0.20.20.10.10.4
Na content in liver0.20.21.20.5-0.30.50.40.21.1-0.1-0.0
Rb content in liver1.72.04.0-1.22.0-0.9-1.21.9-0.31.7-1.3
Se content in liver0.40.51.7-0.30.4-0.3-0.50.8-0.00.9-1.3
Sr content in liver0.30.30.8-0.0-0.7-0.20.0-0.8-0.9-0.50.2
Zn content in liver1.71.93.6-1.01.4-1.0-1.21.6-0.51.7-1.9
Bone: minimum diameter2.85.17.5-2.72.6-2.7-2.62.1-1.82.0-1.0
Time in familiar zone, hab. session 10.10.10.5-0.30.1-0.2-0.2-0.2-0.70.00.2
Time in novel zone, hab. session 10.00.00.20.20.00.20.10.20.4-0.0-0.2
Total zone transitions, hab. session 10.30.51.50.5-0.30.60.7-0.60.6-0.61.2
Total locomotion distance, hab. session 10.10.10.3-0.20.5-0.1-0.00.30.40.10.6
Locomotion velocity, hab. session 10.10.10.2-0.20.5-0.0-0.00.30.50.20.5
Time in familiar zone, hab. session 20.20.20.40.6-0.40.60.6-0.40.2-0.30.0
Time in novel zone, hab. session 20.10.10.6-0.0-0.00.10.1-0.20.4-0.30.8
Total zone transitions, hab. session 20.50.73.00.60.21.00.70.21.7-0.00.8
Total locomotion distance, hab. session 20.50.61.6-0.21.10.1-0.11.11.20.80.0
Locomotion velocity, hab. session 20.60.81.9-0.51.4-0.1-0.41.31.01.0-0.1
Novel to familiar place preference ratio2.73.04.9-2.21.6-2.2-2.01.2-1.91.4-0.7
Novelty place preference2.72.94.8-2.21.5-2.2-2.01.2-2.01.3-0.6
Time in novel zone, NPP test2.22.43.9-2.01.4-2.0-1.81.1-1.71.2-0.5
Total zone transitions, NPP test0.91.35.21.1-0.11.41.10.12.3-0.30.8
Total locomotion distance, NPP test0.50.73.40.40.60.70.40.81.90.50.3
Locomotion velocity, NPP test0.40.52.00.10.70.40.10.91.40.60.1
Intraocular pressure0.91.32.0-0.91.3-0.8-1.11.4-0.41.4-1.3
Delta distance traveled before/after self-admin0.50.51.00.9-0.30.90.7-0.00.9-0.3-1.0
Delta ambulatory time before/after self-admin1.31.63.01.7-0.81.61.3-0.51.7-0.7-0.9
Parametrial fat weight0.41.12.0-0.91.2-0.8-1.01.4-0.21.4-0.9
Pavlov. Cond. lever latency1.01.22.61.4-0.61.51.3-0.41.6-0.60.6
Pavlov. Cond. magazine entry latency2.32.94.9-2.11.3-2.2-2.01.1-2.11.3-0.9
Pavlov. Cond. change in total contacts0.50.62.0-0.90.1-1.0-0.8-0.2-1.40.00.1
Pavlov. Cond. index score2.93.65.7-2.31.6-2.4-2.21.5-2.01.6-1.2
Pavlov. Cond. latency score2.32.94.8-2.11.3-2.2-2.01.2-2.01.3-1.1
Pavlov. Cond. lever contacts0.60.71.4-1.10.6-1.2-1.10.6-1.00.6-0.5
Pavlov. Cond. magazine entry number2.63.36.42.3-1.22.42.1-0.92.5-1.20.9
Pavlov. Cond. intertrial magazine entries0.40.40.9-0.20.9-0.1-0.30.90.30.9-0.7
Pavlov. Cond. lever-magazine prob. diff.2.73.45.5-2.31.6-2.3-2.21.5-1.91.5-1.0
Pavlov. Cond. response bias1.92.34.3-2.01.0-2.1-1.80.8-2.11.0-0.6
Pavlov. Cond. lever latency0.81.12.10.7-1.20.50.8-1.5-0.3-1.41.2
Pavlov. Cond. magazine entry latency1.92.34.21.8-1.21.91.7-0.92.0-1.10.8
Pavlov. Cond. change in total contacts0.20.31.00.6-0.20.70.50.01.0-0.00.0
Pavlov. Cond. index score0.20.21.00.5-0.10.60.50.11.00.0-0.0
Pavlov. Cond. latency score0.20.31.30.6-0.10.70.50.21.10.1-0.1
Pavlov. Cond. lever contacts0.60.81.7-0.51.0-0.3-0.61.30.31.3-1.1
Pavlov. Cond. magazine entry number1.31.63.4-1.51.1-1.5-1.40.7-1.80.9-0.7
Pavlov. Cond. intertrial magazine entries1.42.23.3-1.61.8-1.4-1.51.6-1.01.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.41.30.8-0.40.80.7-0.11.1-0.20.1
Pavlov. Cond. response bias0.10.10.60.20.20.30.10.40.80.3-0.2
Time in closed arm before self-admin0.30.41.0-0.0-0.6-0.10.2-0.8-0.8-0.81.0
Time in closed arm after self-admin0.80.81.60.6-1.30.50.6-1.00.7-1.20.9
Time in open arm before self-admin0.20.20.50.30.50.50.20.50.70.6-0.3
Time in open arm after self-admin0.00.00.10.20.40.20.20.1-0.00.30.0
Bone: periosteal estimation1.42.95.4-2.12.3-1.9-1.81.6-1.11.50.0
Bone: periosteal perimeter3.35.69.3-3.02.5-3.1-2.71.6-2.71.7-0.4
Bone: post-yield work0.00.10.20.10.30.30.2-0.00.30.00.5
Progressive ratio test 1 active lever presses0.30.41.4-0.51.2-0.5-0.50.60.30.7-0.2
Progressive ratio test 1 breakpoint0.40.51.6-0.61.3-0.6-0.60.70.30.8-0.3
Progressive ratio test 1 inactive lever presses2.33.37.0-1.62.6-1.5-1.72.2-0.22.1-1.5
Progressive ratio test 2 active lever presses0.30.41.2-0.41.1-0.4-0.50.7-0.10.7-0.4
Progressive ratio test 2 breakpoint0.30.41.3-0.51.1-0.4-0.60.7-0.10.7-0.3
Progressive ratio test 2 inactive lever presses0.30.41.3-0.71.1-0.7-0.60.4-0.50.50.1
Incentive Sensitization - Responses0.30.40.6-0.40.8-0.4-0.60.8-0.30.8-0.8
Incentive Sensitization - Breakpoint0.30.30.6-0.40.7-0.3-0.50.7-0.40.7-0.7
Sum of active levers in priming session hrs 5-61.00.93.3-1.10.3-1.2-1.00.3-1.80.4-0.1
Progressive ratio0.71.01.61.0-1.01.01.1-1.20.4-1.01.3
Food seeking constrained by brief footshock0.20.20.70.3-0.80.00.1-0.6-0.7-0.3-0.1
Seeking ratio, punishment vs. effort0.10.20.6-0.30.3-0.3-0.40.6-0.00.6-0.7
Retroperitoneal fat weight2.39.816.3-3.23.7-3.1-3.34.0-1.03.5-2.0
Reaction time number correct0.61.25.70.50.90.90.51.12.40.50.0
Reaction time mean minus median0.10.30.70.3-0.50.00.2-0.6-0.7-0.5-0.8
Reaction time mean minus median AUC0.00.10.30.1-0.0-0.00.0-0.2-0.4-0.2-0.5
Reaction time num false alarms0.10.20.40.6-0.60.50.5-0.5-0.0-0.1-0.3
Reaction time num false alarms AUC0.30.51.01.0-0.90.90.9-0.70.4-0.5-0.0
Reaction time trials correct on left0.61.25.70.50.90.90.51.12.40.50.0
Reaction time trials on left0.61.25.80.50.90.90.51.12.40.50.0
Reaction time mean0.30.40.9-0.50.7-0.5-0.50.6-0.60.6-0.9
Reaction time mean AUC0.20.30.7-0.20.7-0.2-0.30.6-0.20.6-0.8
Median of all reaction times0.30.40.8-0.60.9-0.5-0.50.7-0.40.8-0.6
Reaction time omissions0.10.10.6-0.00.4-0.1-0.10.40.10.3-0.8
Reaction time false alarm rate0.40.61.50.6-1.20.30.5-1.2-0.9-0.6-0.2
Reaction time premature initiation rate1.01.42.01.4-1.31.41.3-1.30.8-1.20.3
Reaction time premature initiations0.81.54.01.5-0.71.71.4-0.52.0-0.80.2
Std. dev. reaction times0.20.30.60.8-0.40.60.7-0.60.0-0.5-0.6
Reaction time trials completed0.61.25.80.50.90.90.51.12.40.50.0
Reaction time trials AUC0.61.25.60.50.90.90.51.22.40.50.0
Run reversals in cocaine runway, females0.50.51.01.0-0.41.00.9-0.40.7-0.40.1
Run reversals in cocaine runway, males1.61.62.6-1.40.6-1.6-1.51.0-1.61.0-1.1
Latency to leave start box in cocaine runway0.50.62.00.8-0.40.90.7-0.41.4-0.40.2
Latency to leave start box in cocaine runway, F0.70.83.11.10.11.21.0-0.01.8-0.1-0.1
Latency to leave start box in cocaine runway, M0.10.10.3-0.1-0.6-0.2-0.1-0.30.2-0.30.4
Std. dev. time between licks in bursts0.50.72.20.01.20.40.01.21.50.7-0.0
Total sessions with >9 infusions0.40.50.90.7-0.10.70.8-0.80.7-0.50.9
Short access day 1 total inactive lever presses0.20.20.80.20.10.40.4-0.00.7-0.20.9
Short access day 10 total inactive lever presses1.33.15.2-2.01.5-1.7-2.02.3-0.82.0-1.2
Short access day 1 total infusions1.41.92.51.4-1.01.41.6-1.60.9-1.41.6
Short access day 10 total infusions1.01.32.0-1.11.4-1.2-1.21.0-0.71.3-1.0
Short access total infusions0.00.10.20.20.20.10.2-0.30.2-0.20.4
Short access day 1 locomotion0.30.42.00.2-0.10.10.4-0.9-0.2-0.61.4
Short access day 10 total locomotion0.10.20.5-0.1-0.3-0.3-0.0-0.7-0.7-0.50.6
Short access total locomotion0.20.20.8-0.20.5-0.3-0.1-0.6-0.5-0.30.9
One hour access (0.3 mA shock)0.50.51.9-0.41.4-0.4-0.50.7-0.20.8-0.7
Compulsive drug intake0.40.51.4-0.40.9-0.3-0.51.20.30.8-0.8
One hour access (shock baseline)0.10.10.50.00.70.0-0.10.20.30.4-0.3
Social response proportion0.50.51.00.6-0.50.80.7-0.50.9-0.51.0
Social responses0.50.61.70.5-0.50.60.7-0.41.1-0.61.3
Social time0.20.31.50.20.10.30.4-0.30.4-0.41.2
Soleus weight1.33.95.1-2.02.3-1.9-2.12.1-1.32.2-1.8
Bone: stiffness0.91.54.0-1.51.6-1.1-0.90.7-0.40.42.0
Tibialis anterior weight0.00.10.20.10.50.20.00.40.40.4-0.4
Time to tail flick, vehicle, before self-admin0.20.20.30.6-0.30.50.5-0.4-0.3-0.1-0.3
Time to tail flick, vehicle, after self-admin2.22.93.81.7-1.41.71.8-1.71.4-2.01.9
Time to tail flick, test, before self-admin0.10.10.30.4-0.60.40.3-0.30.4-0.30.0
Time to tail flick, test, after self-admin1.21.22.30.9-1.50.80.9-1.30.5-1.41.1
Delta time to tail flick, vehicle, before/after SA0.30.31.30.4-0.00.50.4-0.01.1-0.50.3
Delta time to tail flick, test, before/after SA0.60.61.70.2-0.80.20.5-1.1-0.3-1.01.3
Tibia length9.125.141.1-6.45.7-6.1-5.74.1-4.74.1-1.0
Ambulatory time before self-admin1.92.94.7-2.11.4-2.2-2.01.4-1.91.5-0.5
Ambulatory time after self-admin0.60.72.2-0.50.6-0.6-0.71.0-0.50.9-1.5
Bone: tissue strength1.81.84.1-1.62.0-1.3-1.31.5-0.41.30.1
Total heroin consumption0.60.61.7-0.6-0.4-0.7-0.2-0.6-1.3-0.91.1
Bone: trabecular number0.00.10.2-0.1-0.0-0.1-0.20.2-0.10.4-0.5
Bone: trabecular spacing0.40.52.30.20.80.50.21.01.50.40.1
Bone: trabecular thickness1.11.44.2-1.20.5-1.4-1.30.3-2.00.8-1.0
Bone: trabecular tissue density0.81.21.51.2-1.01.21.2-1.10.9-1.00.9
Water consumed over 24 hours0.10.20.50.1-0.7-0.1-0.1-0.4-0.60.1-0.6
Number of responses in last shaping day0.50.52.80.10.40.20.3-0.50.6-0.51.7