Hub : Genes

Fap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC alternative TSS NM_138850.1 0.16 0.12 6.4e-03 0.04 0.06 0.04 0.04 4.3e-02 1.6e-02 5.2e-02 3.4e-02
2 OFC alternative TSS XM_039104226.1 0.15 0.11 9.1e-03 0.04 0.06 0.01 0.04 4.6e-02 1.8e-02 1.4e-01 3.5e-02
3 OFC gene expression Fap 0.15 0.11 3.2e-03 0.09 0.09 0.09 0.08 4.0e-03 3.1e-03 3.7e-03 5.8e-03
4 PL gene expression Fap 0.05 0.03 4.1e-06 0.04 0.04 0.03 0.03 1.2e-05 5.4e-05 2.7e-04 1.4e-04
5 BLA gene expression Fap 0.09 0.06 3.5e-05 0.07 0.09 0.07 0.07 1.3e-04 2.4e-05 8.1e-05 9.7e-05
6 IL mRNA stability Fap 0.21 0.12 5.1e-04 0.15 0.1 0.13 0.13 1.9e-04 2.0e-03 4.3e-04 5.5e-04
7 PL mRNA stability Fap 0.06 0.04 4.0e-06 0.03 0.04 0.04 0.04 2.1e-04 1.3e-05 3.9e-05 3.8e-05
8 Adipose mRNA stability Fap 0.07 0.05 1.5e-07 0.04 0.05 0.05 0.05 4.3e-05 1.5e-06 6.6e-06 6.3e-06
9 Brain gene expression Fap 0.09 0.05 1.6e-08 0.07 0.1 0.08 0.08 3.2e-07 4.0e-09 4.6e-08 9.4e-08
10 Brain mRNA stability Fap 0.2 0.12 1.8e-12 0.15 0.14 0.15 0.16 3.7e-14 6.2e-13 3.3e-14 1.8e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.5-0.40.4-0.50.4-0.4-0.40.50.5-0.40.7
Area under the delay curve0.20.20.50.7-0.70.6-0.60.4-0.0-0.2-0.20.00.1
BMI with tail0.10.40.60.8-0.80.7-0.80.70.6-0.6-0.60.5-0.5
BMI without tail0.20.40.7-0.30.3-0.40.4-0.5-0.80.70.7-0.80.8
Body weight0.21.01.1-1.01.0-1.01.0-1.0-0.91.01.0-1.00.8
Weight adjusted by age0.40.51.21.1-1.10.8-0.90.6-0.1-0.3-0.30.00.2
Bone surface1.12.02.7-1.31.3-1.41.2-1.4-1.51.51.5-1.41.7
Bone volume0.50.81.1-0.90.9-0.90.8-0.9-0.80.90.9-0.81.1
Breakpoint value in progressive ratio session6.87.58.72.6-2.62.7-2.62.82.6-2.9-2.92.8-3.0
Number of licking bursts0.10.10.4-0.20.20.00.20.10.2-0.4-0.40.5-0.6
Context. condit. distance diff. score0.10.20.90.2-0.20.00.1-0.1-0.90.30.3-0.50.6
Locomotion velocity, session 10.10.20.3-0.50.5-0.40.5-0.30.5-0.00.00.1-0.5
Locomotion distance, session 10.00.10.2-0.20.2-0.20.5-0.2-0.20.20.2-0.20.1
Locomotion velocity, session 21.31.62.01.4-1.41.4-1.41.31.1-1.2-1.21.1-0.8
Locomotion distance, session 20.30.40.8-0.40.4-0.50.7-0.5-0.90.70.6-0.70.8
Locomotion velocity, session 30.40.40.60.8-0.80.7-0.80.70.6-0.6-0.60.6-0.3
Locomotion distance, session 31.11.22.2-0.70.7-0.90.8-1.0-1.51.21.2-1.31.4
Stereotopy head waving bouts, day 30.20.20.3-0.60.6-0.60.5-0.5-0.10.50.5-0.40.5
Stereotopy head waving duration, day 30.10.10.2-0.40.4-0.20.3-0.10.4-0.0-0.00.2-0.1
Locomotion velocity, session 70.00.00.10.0-0.00.0-0.1-0.0-0.20.10.1-0.10.2
Locomotion distance, session 70.10.10.20.1-0.10.2-0.10.20.4-0.3-0.40.4-0.5
Stereotopy head waving bouts, day 70.30.40.8-0.30.3-0.40.5-0.5-0.90.60.7-0.80.7
Stereotopy head waving duration, day 70.30.30.7-0.40.4-0.40.5-0.6-0.80.60.6-0.70.6
Locomotion velocity, session 80.00.00.10.3-0.30.2-0.20.2-0.3-0.0-0.0-0.00.1
Locomotion distance, session 80.10.20.80.4-0.40.3-0.10.1-0.90.20.1-0.30.5
Degree of sensitization distance1.91.92.71.1-1.11.3-1.11.31.6-1.5-1.51.5-1.6
Degree of sensitization stereotypy0.10.10.30.3-0.30.2-0.00.0-0.50.10.2-0.30.2
Conditioned locomotion0.40.51.11.0-1.00.7-0.70.5-0.80.0-0.0-0.20.8
Cocaine response after cond. corrected10.511.714.63.0-3.03.3-3.23.43.8-3.6-3.63.7-3.5
Cocaine response after cond. not corrected7.58.29.42.6-2.62.8-2.72.93.1-3.0-3.03.0-2.9
Cocaine response before conditioning2.02.54.1-1.11.1-1.31.2-1.5-2.01.71.8-1.91.7
Saline control response0.30.30.40.5-0.50.6-0.40.60.7-0.6-0.60.7-0.6
Bone: connectivity density0.30.51.0-0.40.4-0.50.5-0.6-0.80.70.7-0.81.0
Bone: cortical apparent density0.20.20.4-0.70.7-0.40.5-0.20.5-0.1-0.20.4-0.5
Bone: cortical area2.33.55.3-2.02.0-2.02.3-2.0-1.71.81.8-1.61.4
Bone: cortical porosity1.71.82.4-1.61.6-1.51.5-1.4-0.91.31.3-1.21.0
Bone: cortical porosity3.53.84.8-2.22.2-2.22.1-2.1-1.51.91.9-1.71.4
Bone: cortical thickness1.42.34.1-1.91.9-1.82.0-1.6-0.81.31.3-1.10.9
Bone: cortical thickness5.36.28.8-2.82.8-2.73.0-2.6-2.12.42.3-2.12.0
Bone: cortical tissue density0.10.20.3-0.60.6-0.30.4-0.10.5-0.2-0.20.4-0.6
Condit. Reinf. active minus inactive responses5.36.06.6-2.42.4-2.52.5-2.5-2.62.52.5-2.52.2
Condit. Reinf. active-inactive response ratio2.42.63.8-1.41.4-1.51.4-1.6-1.91.71.7-1.81.6
Condit. Reinf. active responses4.15.16.0-2.42.4-2.42.4-2.3-2.12.22.2-2.01.8
Condit. Reinf. inactive responses1.21.53.3-1.81.8-1.51.6-1.2-0.20.90.8-0.50.5
Incentive salience index mean4.96.06.7-2.52.5-2.52.5-2.5-2.62.52.5-2.42.1
Condit. Reinf. lever presses0.60.81.0-1.01.0-1.01.0-0.9-0.90.80.8-0.70.6
Condit. Reinf. active minus inactive responses4.15.06.8-1.81.8-2.02.1-2.2-2.62.42.4-2.52.5
Condit. Reinf. active-inactive response ratio3.43.55.3-1.41.4-1.61.6-1.8-2.22.02.0-2.12.3
Condit. Reinf. active responses2.83.95.0-1.81.8-1.91.9-2.0-2.22.12.1-2.12.0
Condit. Reinf. inactive responses0.00.00.2-0.10.10.0-0.10.10.1-0.2-0.20.3-0.5
Condit. Reinf. lever presses1.21.61.9-1.21.2-1.31.2-1.3-1.31.31.4-1.41.1
Condit. Reinf. lever reinforcers received1.72.43.2-1.31.3-1.41.4-1.5-1.81.61.6-1.71.6
Conditioned reinforcement - actives1.01.01.9-0.60.6-0.80.7-0.9-1.41.11.1-1.21.3
Conditioned reinforcement - inactives0.60.72.7-0.50.5-0.60.7-0.6-1.70.70.7-0.70.9
Conditioned locomotion0.00.00.30.1-0.10.10.10.1-0.5-0.0-0.10.00.1
Patch foraging indifference point 0 sec0.10.10.5-0.40.4-0.30.2-0.10.7-0.1-0.10.3-0.3
Patch foraging indifference point AUC0.40.51.20.1-0.1-0.1-0.4-0.3-1.10.70.7-0.91.1
Delay disc. indifference point, 0s delay0.10.20.6-0.10.10.00.10.20.8-0.4-0.40.5-0.5
Delay disc. indifference point, 16s delay0.00.00.2-0.10.1-0.2-0.1-0.2-0.00.20.2-0.20.4
Delay disc. indifference point, 2s delay0.50.60.8-0.70.7-0.70.7-0.7-0.90.80.8-0.80.9
Delay disc. indifference point, 24s delay0.40.40.90.9-0.90.7-0.90.5-0.3-0.2-0.2-0.00.2
Delay disc. indifference point, 4s delay0.40.41.11.0-1.00.8-0.80.6-0.2-0.3-0.2-0.00.1
Delay disc. indifference point, 8s delay0.30.30.70.8-0.80.7-0.60.5-0.0-0.3-0.30.10.0
Indifference point function ln k0.30.41.2-0.90.9-0.71.1-0.6-0.10.40.3-0.10.2
Indifference point function log k0.30.41.2-0.90.9-0.71.1-0.6-0.10.40.3-0.10.2
Patch foraging total patch changes 0 sec0.10.10.6-0.10.10.0-0.10.20.8-0.3-0.30.5-0.4
Patch foraging total patch changes 12 sec0.91.11.4-0.90.9-1.00.8-1.1-1.11.11.2-1.21.2
Patch foraging total patch changes 18 sec0.60.71.1-1.01.0-1.00.7-1.0-0.40.90.9-0.80.7
Patch foraging total patch changes 24 sec0.70.81.4-1.21.2-1.10.6-1.0-0.10.90.9-0.70.7
Patch foraging total patch changes 6 sec0.30.41.00.6-0.60.6-1.00.60.8-0.5-0.50.4-0.5
Patch foraging time to switch 0 sec0.71.12.30.7-0.70.9-0.51.01.2-1.2-1.21.2-1.5
Patch foraging water rate 0 sec2.33.64.3-2.12.1-2.11.9-2.0-1.71.91.9-1.71.7
Patch foraging water rate 12 sec2.53.85.5-2.32.3-2.22.3-2.0-1.31.81.8-1.61.5
Patch foraging water rate 18 sec4.56.17.3-2.72.7-2.72.6-2.6-2.12.42.4-2.22.2
Patch foraging water rate 24 sec2.02.83.7-1.91.9-1.91.7-1.8-1.21.61.6-1.51.3
Patch foraging water rate 6 sec3.65.37.6-2.82.8-2.62.5-2.5-1.62.22.2-1.91.7
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.50.5-0.50.4-0.40.00.30.4-0.30.2
Distance traveled before self-admin3.43.66.4-2.52.5-2.32.4-2.1-0.81.61.6-1.30.7
Distance traveled after self-admin2.52.84.2-2.12.1-2.01.9-1.9-0.51.61.6-1.41.1
Extensor digitorum longus weight0.20.81.3-1.11.1-1.01.1-0.9-0.60.70.7-0.60.5
Bone: elastic displacement0.00.00.10.1-0.10.1-0.10.10.3-0.1-0.10.10.0
Bone: elastic work0.20.20.4-0.50.5-0.50.5-0.5-0.10.50.4-0.30.6
Bone: endosteal estimation0.61.43.2-0.80.8-0.90.7-1.1-1.81.31.3-1.41.4
Bone: endosteal perimeter0.91.94.4-0.80.8-1.11.0-1.3-2.11.51.5-1.71.6
Epididymis fat weight7.617.719.54.3-4.34.4-3.94.43.9-4.3-4.34.1-4.1
Delta time in closed arm before/after self-admin0.40.40.80.9-0.90.8-0.60.60.6-0.4-0.50.3-0.2
Delta time in open arm before/after self-admin1.11.12.1-1.41.4-1.31.1-1.1-1.00.80.8-0.60.5
Diff in mean of infusions in LGA sessions11.012.216.44.0-4.03.9-3.93.72.7-3.3-3.32.9-2.8
Delay discount exponential model param0.20.20.6-0.80.8-0.60.6-0.50.00.30.2-0.1-0.0
Extinction: sum of active levers before priming1.01.03.00.1-0.10.5-0.10.71.3-1.2-1.21.4-1.7
Active lever presses in extinction session 60.20.20.70.3-0.30.4-0.20.40.4-0.5-0.50.6-0.8
Bone: final force2.94.75.2-2.32.3-2.32.2-2.3-2.12.22.2-2.11.9
Bone: final moment2.94.75.3-2.32.3-2.32.3-2.3-2.12.22.1-2.01.9
Food consumed during 24 hour testing period0.40.51.1-0.60.6-0.60.5-0.6-1.10.70.6-0.60.8
Glucose0.91.32.3-0.80.8-1.01.2-1.1-1.51.21.2-1.31.2
Heart weight0.00.00.1-0.20.2-0.10.10.00.3-0.1-0.10.2-0.0
Delay discount hyperbolic model param0.20.20.4-0.70.7-0.50.5-0.40.10.20.2-0.0-0.1
Intermittent access intake day 1-15 change3.83.75.6-2.42.4-2.22.2-2.1-1.31.81.8-1.61.1
Intermittent access intake escalation3.83.75.6-2.42.4-2.22.2-2.1-1.41.81.7-1.51.2
Intermittent access intake escalation 22.82.84.7-2.22.2-2.01.9-1.8-0.91.51.5-1.30.9
Intermitt. access day 1 inactive lever presses0.50.51.10.6-0.60.7-0.40.80.2-0.8-0.80.9-1.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1-0.00.0-0.0-0.10.00.0-0.0-0.1
Intermitt. access escalation Index2.11.83.3-0.70.7-1.00.9-1.2-1.61.61.6-1.81.8
Intermittent access day 1 total infusions0.20.20.30.5-0.50.5-0.40.60.2-0.5-0.60.6-0.6
Intermittent access day 15 total infusions1.01.21.8-1.31.3-1.21.3-1.1-1.10.90.8-0.70.6
Intermittent access terminal intake (last 3 days)1.71.92.5-1.61.6-1.51.6-1.4-1.31.31.2-1.10.9
Intermittent access total infusions0.60.71.6-0.90.9-0.81.0-0.8-1.30.80.7-0.60.6
Intermittent access day 1 locomotion1.51.62.51.0-1.01.2-0.71.31.0-1.5-1.51.6-1.5
Intermittent access day 15 total locomotion0.20.20.7-0.70.7-0.40.8-0.3-0.30.0-0.10.3-0.2
Intermittent access total locomotion0.20.20.50.1-0.10.30.20.40.1-0.5-0.60.7-0.7
Intermittent access standard deviation1.41.53.6-1.81.8-1.51.9-1.2-0.70.70.6-0.30.0
Left kidney weight0.41.21.6-1.31.3-1.21.2-1.2-0.71.01.0-0.90.8
Right kidney weight0.61.52.3-1.51.5-1.41.5-1.3-1.01.11.1-1.00.9
Cocaine induced anxiety0.20.20.50.7-0.70.6-0.50.5-0.2-0.2-0.20.1-0.1
Post-drug Anxiety0.30.30.60.8-0.80.7-0.60.60.0-0.4-0.40.3-0.2
Baseline Anxiety0.00.10.1-0.40.4-0.30.3-0.2-0.10.10.10.0-0.0
Tail length2.57.79.7-2.42.4-2.62.6-2.8-3.12.92.9-3.02.9
Length with tail1.03.74.5-2.02.0-2.02.1-2.0-1.71.91.9-1.81.6
Length without tail0.30.61.2-1.11.1-0.91.1-0.8-0.20.50.6-0.4-0.0
Times rat made contact with spout4.85.67.22.5-2.52.5-2.72.51.9-2.4-2.42.3-2.1
Lifetime Intake0.91.02.1-1.11.1-1.01.1-0.9-1.50.80.8-0.70.7
Liver weight, left0.20.30.70.1-0.10.3-0.20.40.8-0.6-0.60.8-0.8
Liver weight, right0.20.41.20.2-0.20.40.00.50.8-0.7-0.80.9-1.1
Locomotor activity1.72.74.7-2.22.2-2.01.9-1.8-0.51.51.5-1.21.0
Locomotor testing distance4.16.911.0-3.33.3-3.13.1-2.8-1.42.42.3-2.01.7
Locomotor testing rearing4.46.911.4-3.43.4-3.13.1-2.8-1.62.32.2-1.81.5
Locomotion in novel chamber1.11.32.41.3-1.31.2-1.61.20.9-1.1-1.11.0-0.7
Locomotion in novel chamber post-restriction0.60.70.9-1.01.0-0.91.0-0.9-0.50.80.8-0.70.5
Fecal boli incidents, locomotor time 10.20.20.4-0.70.7-0.60.6-0.50.20.40.4-0.30.1
Change in fecal boli incidents, locomotor task0.00.00.1-0.10.10.00.00.10.2-0.2-0.30.4-0.3
Time >=10cm from walls, locomotor time 10.20.20.6-0.80.8-0.60.7-0.5-0.10.30.2-0.10.0
Bouts of movement, locomotor time 11.82.02.21.5-1.51.5-1.51.51.2-1.4-1.41.4-1.2
Total resting periods, locomotor time 11.41.51.81.3-1.31.3-1.31.31.1-1.2-1.21.1-1.0
Rest time, locomotor task time 11.61.82.31.5-1.51.5-1.41.41.4-1.2-1.21.1-0.9
Distance moved, locomotor task time 12.22.43.6-1.91.9-1.81.6-1.7-1.21.51.4-1.21.1
Vertical activity count, locomotor time 10.40.40.7-0.90.9-0.80.7-0.7-0.40.50.5-0.40.3
Time >=10cm from walls, locomotor time 20.40.51.40.0-0.00.2-0.10.41.2-0.7-0.70.9-1.0
Bouts of movement, locomotor time 20.80.91.10.9-0.90.9-1.01.00.9-1.0-1.01.0-0.9
Total resting periods, locomotor time 20.91.01.11.0-1.01.0-1.11.10.9-1.1-1.11.1-0.9
Rest time, locomotor task time 20.20.20.60.6-0.60.5-0.80.40.1-0.2-0.30.10.0
Distance moved, locomotor task time 20.50.51.3-1.11.1-0.91.1-0.7-0.10.50.4-0.20.2
Vertical activity count, locomotor time 20.10.20.4-0.10.10.1-0.00.20.6-0.4-0.50.6-0.6
Light reinforcement 10.61.11.8-0.60.6-0.80.8-1.0-1.31.21.2-1.31.3
Light reinforcement 21.01.42.5-0.60.5-0.80.8-1.0-1.51.31.4-1.51.6
Bone: marrow area0.71.43.3-0.80.8-1.00.7-1.1-1.81.31.3-1.41.4
Bone: maximum diameter1.01.82.9-1.11.1-1.21.5-1.3-1.71.31.4-1.51.2
Bone: maximum force3.05.26.4-2.52.5-2.52.4-2.4-2.02.22.2-2.01.8
Bone: maximum moment3.05.26.6-2.62.6-2.52.5-2.4-2.02.22.2-2.01.8
Mean time between licks in bursts0.10.10.60.1-0.10.2-0.30.20.8-0.3-0.30.3-0.4
Mean num. licks in bursts1.21.52.81.6-1.61.4-1.71.30.8-1.0-1.00.8-0.5
Cd content in liver1.61.72.01.2-1.21.3-1.21.41.4-1.3-1.41.4-1.3
Co content in liver0.20.20.90.0-0.0-0.10.1-0.2-0.90.50.4-0.50.9
Cu content in liver0.70.81.0-0.90.9-0.90.8-0.9-0.61.01.0-0.91.0
Fe content in liver0.20.30.50.7-0.70.6-0.60.60.3-0.4-0.50.4-0.1
K content in liver1.11.11.8-0.70.7-0.90.8-1.0-1.31.11.2-1.31.0
Mg content in liver0.90.91.6-0.60.7-0.80.7-1.0-1.21.11.2-1.31.0
Mn content in liver8.09.110.4-2.82.8-3.03.1-3.1-2.93.23.2-3.22.9
Na content in liver3.33.54.9-2.12.1-2.12.2-2.0-1.31.81.8-1.71.4
Rb content in liver0.20.30.5-0.40.4-0.50.4-0.5-0.50.70.7-0.70.6
Se content in liver1.82.23.91.0-1.01.2-1.01.41.8-1.6-1.61.7-2.0
Sr content in liver0.70.61.2-1.11.1-0.91.0-0.8-0.50.60.6-0.50.4
Zn content in liver1.01.11.21.1-1.11.1-1.01.10.9-1.1-1.11.0-1.1
Bone: minimum diameter0.61.21.8-1.11.1-1.11.4-1.1-1.11.01.0-1.00.8
Time in familiar zone, hab. session 10.20.20.40.7-0.70.5-0.50.4-0.3-0.1-0.1-0.00.1
Time in novel zone, hab. session 10.90.92.10.3-0.30.5-0.60.71.5-1.0-1.11.2-1.3
Total zone transitions, hab. session 10.91.21.9-1.31.3-1.21.4-1.1-1.11.01.0-0.90.7
Total locomotion distance, hab. session 11.92.73.8-1.61.6-1.61.8-1.6-1.91.61.6-1.51.6
Locomotion velocity, hab. session 11.52.12.9-1.41.4-1.41.7-1.4-1.71.41.4-1.31.3
Time in familiar zone, hab. session 22.02.13.31.8-1.81.7-1.51.61.0-1.3-1.31.1-1.0
Time in novel zone, hab. session 20.80.81.9-1.41.4-1.21.1-1.0-0.30.70.7-0.50.2
Total zone transitions, hab. session 20.50.71.5-1.01.0-0.91.2-0.9-0.70.70.7-0.60.4
Total locomotion distance, hab. session 21.01.32.1-1.01.0-1.01.4-1.1-1.41.11.1-1.11.0
Locomotion velocity, hab. session 20.71.01.7-0.90.9-0.91.3-0.9-1.21.00.9-1.00.9
Novel to familiar place preference ratio1.81.94.00.8-0.81.1-1.01.22.0-1.5-1.51.6-1.7
Novelty place preference2.32.34.90.9-0.91.1-1.11.32.2-1.7-1.61.8-1.9
Time in novel zone, NPP test2.62.76.10.8-0.81.2-1.11.42.5-1.8-1.82.0-2.2
Total zone transitions, NPP test0.00.00.10.1-0.10.10.30.0-0.30.0-0.0-0.1-0.2
Total locomotion distance, NPP test1.01.42.7-0.80.8-0.91.3-1.1-1.71.21.2-1.31.2
Locomotion velocity, NPP test1.31.94.0-0.80.8-1.01.3-1.2-2.01.51.4-1.61.5
Intraocular pressure1.11.52.6-1.61.6-1.51.6-1.3-0.41.11.1-0.80.6
Delta distance traveled before/after self-admin0.30.30.80.9-0.90.7-0.80.6-0.0-0.3-0.30.20.2
Delta ambulatory time before/after self-admin0.40.41.4-0.20.2-0.40.3-0.5-0.90.80.7-0.81.2
Parametrial fat weight4.99.610.63.1-3.13.2-2.83.22.9-3.3-3.23.1-3.1
Pavlov. Cond. lever latency0.40.61.10.6-0.60.7-0.60.71.1-0.8-0.80.8-0.9
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.10.10.00.10.2-0.2-0.20.2-0.2
Pavlov. Cond. change in total contacts1.51.62.0-1.21.2-1.21.3-1.2-1.41.31.3-1.21.2
Pavlov. Cond. index score0.30.40.5-0.70.7-0.70.7-0.7-0.70.70.7-0.60.6
Pavlov. Cond. latency score0.30.40.5-0.60.6-0.60.6-0.6-0.70.70.7-0.70.7
Pavlov. Cond. lever contacts0.81.01.2-0.90.9-1.00.9-1.0-1.11.01.0-1.01.0
Pavlov. Cond. magazine entry number0.40.50.60.6-0.60.7-0.70.70.8-0.7-0.70.7-0.7
Pavlov. Cond. intertrial magazine entries1.11.31.7-1.11.1-1.10.8-1.2-1.21.21.2-1.21.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.70.7-0.70.7-0.7-0.60.60.7-0.60.5
Pavlov. Cond. response bias0.60.81.0-0.80.8-0.80.9-0.9-1.00.90.9-0.90.9
Pavlov. Cond. lever latency0.30.41.01.0-1.00.8-0.90.7-0.1-0.4-0.40.30.3
Pavlov. Cond. magazine entry latency2.73.13.51.9-1.91.9-1.71.81.6-1.8-1.71.6-1.8
Pavlov. Cond. change in total contacts0.00.10.2-0.30.3-0.20.3-0.20.2-0.00.00.0-0.4
Pavlov. Cond. index score0.81.12.00.9-0.90.9-0.81.01.2-1.1-1.01.0-1.4
Pavlov. Cond. latency score1.01.32.01.0-1.01.1-1.01.11.2-1.1-1.11.1-1.4
Pavlov. Cond. lever contacts0.10.20.4-0.60.6-0.50.6-0.40.10.20.2-0.1-0.4
Pavlov. Cond. magazine entry number2.43.03.5-1.91.9-1.81.7-1.7-1.61.71.6-1.51.8
Pavlov. Cond. intertrial magazine entries4.86.29.1-2.02.0-2.32.0-2.4-2.82.72.7-2.83.0
Pavlov. Cond. lever-magazine prob. diff.0.81.11.90.9-0.90.9-0.91.01.2-1.0-1.01.0-1.4
Pavlov. Cond. response bias0.30.41.30.1-0.10.3-0.00.40.9-0.6-0.60.7-1.1
Time in closed arm before self-admin0.10.10.20.4-0.40.2-0.40.20.10.00.0-0.10.4
Time in closed arm after self-admin0.10.10.60.3-0.30.1-0.1-0.0-0.10.30.3-0.50.8
Time in open arm before self-admin2.22.33.31.8-1.81.7-1.71.61.3-1.4-1.41.2-1.2
Time in open arm after self-admin0.40.51.20.1-0.10.3-0.40.50.8-0.8-0.81.0-1.1
Bone: periosteal estimation1.83.74.4-1.91.9-1.91.9-2.0-2.11.91.9-1.91.7
Bone: periosteal perimeter1.72.83.4-1.61.6-1.71.8-1.7-1.81.71.7-1.71.5
Bone: post-yield work1.21.62.3-1.51.5-1.41.3-1.3-1.11.21.1-1.00.9
Progressive ratio test 1 active lever presses1.31.32.5-1.11.1-1.11.4-1.1-1.61.01.0-1.01.0
Progressive ratio test 1 breakpoint2.42.53.9-1.51.5-1.51.8-1.5-2.01.51.4-1.41.4
Progressive ratio test 1 inactive lever presses0.10.20.40.3-0.30.3-0.10.4-0.0-0.5-0.50.5-0.7
Progressive ratio test 2 active lever presses0.30.31.60.0-0.0-0.20.1-0.3-1.30.50.5-0.60.7
Progressive ratio test 2 breakpoint0.60.72.5-0.30.3-0.50.3-0.6-1.60.90.8-1.01.0
Progressive ratio test 2 inactive lever presses0.70.82.2-0.70.7-0.80.8-0.8-1.50.90.9-0.90.9
Incentive Sensitization - Responses1.21.24.10.0-0.0-0.40.1-0.7-2.01.11.1-1.41.6
Incentive Sensitization - Breakpoint1.11.13.7-0.00.0-0.40.1-0.7-1.91.11.1-1.41.6
Sum of active levers in priming session hrs 5-63.13.04.71.4-1.41.6-1.51.71.4-2.0-1.92.0-2.2
Progressive ratio0.30.40.8-0.70.7-0.70.9-0.6-0.60.50.5-0.40.1
Food seeking constrained by brief footshock0.00.10.20.2-0.2-0.0-0.5-0.10.20.20.3-0.30.2
Seeking ratio, punishment vs. effort0.20.20.70.5-0.50.4-0.90.40.7-0.3-0.20.2-0.0
Retroperitoneal fat weight4.815.717.54.1-4.14.2-3.84.23.6-4.0-4.13.9-3.6
Reaction time number correct0.30.41.5-0.50.5-0.20.30.01.2-0.5-0.50.7-0.9
Reaction time mean minus median1.82.42.81.6-1.61.6-1.71.61.4-1.5-1.61.5-1.4
Reaction time mean minus median AUC2.73.44.42.1-2.12.0-2.02.01.4-1.8-1.81.7-1.4
Reaction time num false alarms1.72.32.7-1.51.5-1.51.6-1.5-1.51.51.5-1.41.4
Reaction time num false alarms AUC1.92.63.4-1.71.7-1.71.8-1.7-1.51.61.5-1.51.5
Reaction time trials correct on left0.30.41.5-0.50.5-0.20.30.01.2-0.5-0.50.7-0.9
Reaction time trials on left0.30.41.4-0.50.5-0.20.30.01.2-0.5-0.50.7-0.9
Reaction time mean1.01.52.41.6-1.61.5-1.31.40.1-1.1-1.11.0-0.7
Reaction time mean AUC1.52.03.31.8-1.81.7-1.61.60.2-1.3-1.31.2-0.8
Median of all reaction times0.50.71.31.1-1.11.0-0.90.9-0.4-0.6-0.70.5-0.2
Reaction time omissions1.52.02.71.6-1.61.6-1.41.51.0-1.4-1.41.3-1.2
Reaction time false alarm rate1.62.33.9-1.11.1-1.31.4-1.4-2.01.61.6-1.71.8
Reaction time premature initiation rate0.50.61.70.7-0.70.7-0.90.71.3-0.7-0.70.7-0.6
Reaction time premature initiations0.50.73.20.3-0.30.5-0.70.61.8-0.8-0.80.9-0.9
Std. dev. reaction times1.52.22.61.6-1.61.6-1.51.61.0-1.5-1.51.4-1.2
Reaction time trials completed0.30.41.4-0.50.5-0.20.30.01.2-0.5-0.50.7-0.9
Reaction time trials AUC0.20.40.9-0.90.9-0.60.6-0.40.7-0.0-0.00.3-0.4
Run reversals in cocaine runway, females0.10.10.40.0-0.00.1-0.20.20.7-0.3-0.30.4-0.3
Run reversals in cocaine runway, males0.40.41.01.0-1.00.7-0.90.5-0.4-0.00.0-0.30.4
Latency to leave start box in cocaine runway0.50.51.21.1-1.10.9-0.70.7-0.6-0.3-0.40.10.0
Latency to leave start box in cocaine runway, F0.30.40.91.0-1.00.8-0.60.6-0.6-0.3-0.30.1-0.1
Latency to leave start box in cocaine runway, M0.10.10.30.4-0.40.3-0.20.2-0.5-0.0-0.1-0.00.2
Std. dev. time between licks in bursts1.51.82.5-1.61.6-1.51.6-1.5-0.61.31.3-1.20.9
Total sessions with >9 infusions0.20.30.70.0-0.00.30.10.40.2-0.7-0.70.8-0.8
Short access day 1 total inactive lever presses0.00.00.10.1-0.10.10.20.1-0.3-0.1-0.10.1-0.2
Short access day 10 total inactive lever presses0.10.10.1-0.40.4-0.30.3-0.2-0.20.10.1-0.0-0.3
Short access day 1 total infusions1.11.22.6-1.11.1-1.11.2-1.0-1.61.01.0-0.90.8
Short access day 10 total infusions1.21.42.8-1.31.3-1.21.5-1.0-1.71.00.8-0.70.9
Short access total infusions0.70.82.0-1.01.0-0.91.1-0.8-1.40.70.7-0.50.5
Short access day 1 locomotion0.20.20.60.0-0.00.20.20.4-0.3-0.6-0.70.8-0.7
Short access day 10 total locomotion0.40.40.60.8-0.80.8-0.20.8-0.6-0.7-0.80.7-0.3
Short access total locomotion0.50.61.30.5-0.50.7-0.00.8-0.2-0.9-1.11.1-0.9
One hour access (0.3 mA shock)0.10.20.9-0.40.4-0.30.5-0.3-0.90.30.2-0.20.2
Compulsive drug intake5.55.66.72.6-2.62.6-2.22.62.0-2.4-2.52.4-1.9
One hour access (shock baseline)2.02.33.5-1.51.5-1.51.4-1.5-1.91.51.5-1.51.3
Social response proportion1.11.22.61.6-1.61.3-1.51.10.7-0.8-0.70.5-0.4
Social responses1.62.13.2-1.01.0-1.31.1-1.4-1.51.61.7-1.81.6
Social time0.30.40.60.8-0.80.8-0.60.70.1-0.6-0.70.6-0.5
Soleus weight0.00.10.2-0.40.4-0.40.4-0.3-0.20.30.3-0.20.3
Bone: stiffness3.65.76.8-2.62.6-2.62.5-2.5-2.22.32.3-2.21.8
Tibialis anterior weight0.20.60.80.8-0.80.8-0.80.90.7-0.8-0.80.9-0.6
Time to tail flick, vehicle, before self-admin3.94.04.82.2-2.22.2-2.12.11.4-2.1-2.01.9-1.8
Time to tail flick, vehicle, after self-admin2.62.83.21.6-1.61.7-1.51.71.4-1.8-1.81.7-1.7
Time to tail flick, test, before self-admin0.20.20.90.3-0.30.1-0.1-0.1-0.80.40.4-0.60.9
Time to tail flick, test, after self-admin0.10.10.2-0.40.4-0.30.4-0.3-0.30.20.1-0.00.2
Delta time to tail flick, vehicle, before/after SA0.90.91.1-1.01.0-1.11.1-1.0-0.81.01.0-0.90.8
Delta time to tail flick, test, before/after SA0.30.30.70.2-0.20.3-0.20.50.6-0.7-0.70.8-0.8
Tibia length7.420.928.3-4.04.0-4.34.1-4.5-5.34.84.7-4.84.8
Ambulatory time before self-admin2.82.95.8-2.42.4-2.12.2-1.8-0.61.31.3-0.90.3
Ambulatory time after self-admin1.31.42.0-1.41.4-1.41.2-1.3-0.51.21.2-1.10.9
Bone: tissue strength1.11.01.6-1.31.3-1.21.2-1.0-0.70.90.9-0.70.8
Total heroin consumption2.73.25.61.1-1.11.4-1.41.62.3-1.9-1.92.1-2.4
Bone: trabecular number0.30.41.0-0.50.5-0.60.5-0.6-0.90.70.7-0.61.0
Bone: trabecular spacing0.91.21.71.0-1.01.0-1.01.01.2-1.1-1.01.0-1.3
Bone: trabecular thickness1.72.02.3-1.51.5-1.51.5-1.4-1.51.41.3-1.31.3
Bone: trabecular tissue density0.10.20.4-0.60.6-0.50.6-0.4-0.10.20.2-0.2-0.2
Water consumed over 24 hours0.10.10.2-0.40.4-0.40.4-0.4-0.30.30.3-0.30.2
Number of responses in last shaping day2.12.12.5-1.31.3-1.41.3-1.5-1.51.61.6-1.61.6