Hub : Genes

Fap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Fap 0.14 0.1 3.6e-03 0.09 0.11 0.09 0.1 4.2e-03 1.7e-03 3.2e-03 2.9e-03
2 PL gene expression Fap 0.05 0.04 2.6e-06 0.05 0.05 0.03 0.04 9.1e-06 3.3e-06 1.4e-04 2.5e-05
3 BLA gene expression Fap 0.09 0.06 2.2e-05 0.07 0.1 0.09 0.09 1.1e-04 1.0e-05 2.6e-05 2.7e-05
4 PL mRNA stability Fap 0.05 0.04 5.6e-06 0.05 0.05 0.05 0.05 7.1e-06 2.3e-06 3.2e-06 2.1e-06
5 Adipose mRNA stability Fap 0.07 0.05 1.8e-07 0.04 0.05 0.04 0.05 2.8e-05 1.6e-06 1.5e-05 2.0e-06
6 Brain gene expression Fap 0.1 0.06 4.3e-09 0.09 0.1 0.09 0.09 1.3e-08 2.9e-09 7.6e-09 1.3e-08
7 Brain mRNA stability Fap 0.19 0.11 4.2e-13 0.15 0.14 0.13 0.14 1.3e-13 5.1e-13 3.9e-12 1.5e-12
8 IL mRNA stability Fap 0.2 0.11 5.9e-04 0.1 0.11 0.12 0.12 2.1e-03 1.3e-03 9.3e-04 6.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.4-0.5-0.4-0.40.10.4-0.4-0.60.2
Area under the delay curve0.10.10.50.40.70.3-0.1-0.1-0.1-0.20.2
BMI with tail0.00.00.1-0.2-0.3-0.10.00.00.10.00.1
BMI without tail0.21.11.4-1.2-1.2-1.11.11.0-0.9-0.91.0
Body weight0.20.80.9-1.0-0.9-0.90.90.9-0.9-0.70.8
Weight adjusted by age0.20.61.91.01.40.9-0.5-0.70.40.1-0.3
Bone surface0.91.72.4-1.4-1.2-1.41.11.4-1.3-1.51.1
Bone volume0.30.60.9-0.9-0.9-0.90.50.9-0.7-0.90.5
Breakpoint value in progressive ratio session6.611.912.93.42.93.5-3.5-3.63.53.6-3.6
Number of licking bursts0.10.20.80.1-0.30.2-0.5-0.40.50.5-0.9
Context. condit. distance diff. score0.10.10.3-0.00.3-0.20.40.3-0.5-0.50.5
Locomotion velocity, session 10.20.20.6-0.3-0.8-0.3-0.10.10.10.5-0.6
Locomotion distance, session 10.00.00.1-0.2-0.2-0.20.30.2-0.2-0.10.2
Locomotion velocity, session 21.21.42.11.41.51.3-1.3-1.21.10.8-0.8
Locomotion distance, session 20.30.40.9-0.5-0.2-0.50.70.6-0.7-0.80.9
Locomotion velocity, session 30.30.30.70.70.80.7-0.5-0.60.50.3-0.0
Locomotion distance, session 31.31.52.9-0.9-0.5-1.01.41.2-1.3-1.41.7
Stereotopy head waving bouts, day 30.20.30.4-0.6-0.6-0.50.50.5-0.4-0.60.6
Stereotopy head waving duration, day 30.00.10.1-0.1-0.30.0-0.2-0.20.30.3-0.3
Locomotion velocity, session 70.00.00.0-0.00.1-0.10.10.1-0.2-0.20.2
Locomotion distance, session 70.10.10.20.2-0.00.2-0.2-0.30.30.5-0.4
Stereotopy head waving bouts, day 70.10.20.4-0.3-0.2-0.40.40.5-0.6-0.40.4
Stereotopy head waving duration, day 70.20.20.4-0.4-0.3-0.50.50.5-0.7-0.40.4
Locomotion velocity, session 80.00.00.10.20.30.2-0.2-0.1-0.0-0.1-0.0
Locomotion distance, session 80.10.10.30.20.50.10.20.1-0.3-0.40.5
Degree of sensitization distance2.22.33.71.41.01.4-1.6-1.51.61.7-1.9
Degree of sensitization stereotypy0.00.00.10.20.40.00.10.1-0.4-0.20.1
Conditioned locomotion0.50.52.10.71.40.60.1-0.2-0.2-0.90.8
Cocaine response after cond. corrected8.012.013.63.32.83.5-3.6-3.63.73.5-3.5
Cocaine response after cond. not corrected5.58.08.62.82.42.8-2.9-2.92.92.9-2.9
Cocaine response before conditioning2.42.94.1-1.5-1.2-1.71.81.9-2.0-1.81.6
Saline control response0.20.30.40.50.40.6-0.6-0.60.60.4-0.5
Bone: connectivity density0.30.40.9-0.6-0.3-0.60.40.7-0.7-1.00.6
Bone: cortical apparent density0.10.20.5-0.3-0.7-0.2-0.1-0.10.40.4-0.5
Bone: cortical area2.74.36.0-2.3-2.4-2.32.12.2-2.0-1.61.6
Bone: cortical porosity1.31.42.0-1.3-1.4-1.31.21.2-1.1-0.80.9
Bone: cortical porosity3.33.75.0-2.2-2.2-2.11.92.0-1.8-1.51.5
Bone: cortical thickness2.03.36.0-2.2-2.4-2.01.81.8-1.4-1.21.4
Bone: cortical thickness5.16.28.2-2.8-2.9-2.72.52.5-2.2-2.12.1
Bone: cortical tissue density0.10.20.4-0.2-0.6-0.1-0.2-0.20.40.5-0.6
Condit. Reinf. active minus inactive responses5.56.27.6-2.6-2.4-2.62.82.6-2.5-2.12.4
Condit. Reinf. active-inactive response ratio2.62.73.4-1.6-1.3-1.71.81.8-1.8-1.61.6
Condit. Reinf. active responses4.15.36.2-2.5-2.5-2.42.52.3-2.1-1.82.2
Condit. Reinf. inactive responses1.01.33.5-1.5-1.9-1.31.00.9-0.4-0.60.9
Incentive salience index mean4.76.07.2-2.6-2.5-2.62.72.6-2.4-2.02.2
Condit. Reinf. lever presses0.40.71.0-0.9-1.0-0.90.80.9-0.7-0.50.5
Condit. Reinf. active minus inactive responses3.35.16.5-2.1-1.6-2.22.42.3-2.5-2.52.3
Condit. Reinf. active-inactive response ratio2.53.95.8-1.7-1.2-1.82.12.0-2.2-2.42.2
Condit. Reinf. active responses2.53.64.2-1.9-1.6-1.92.02.0-2.1-2.01.8
Condit. Reinf. inactive responses0.10.10.30.1-0.10.2-0.4-0.30.40.5-0.6
Condit. Reinf. lever presses1.21.82.2-1.4-1.5-1.51.41.5-1.4-1.00.9
Condit. Reinf. lever reinforcers received1.62.32.8-1.5-1.2-1.51.51.6-1.7-1.61.4
Conditioned reinforcement - actives0.31.42.3-1.4-1.5-1.31.21.2-1.0-0.80.8
Conditioned reinforcement - inactives0.10.20.4-0.4-0.4-0.30.70.2-0.2-0.30.6
Conditioned locomotion0.20.30.60.30.00.4-0.5-0.60.70.8-0.6
Patch foraging indifference point 0 sec0.00.10.2-0.1-0.40.0-0.4-0.20.40.3-0.5
Patch foraging indifference point AUC0.20.51.2-0.30.2-0.50.70.8-1.0-1.10.8
Delay disc. indifference point, 0s delay0.10.10.30.1-0.20.2-0.3-0.40.50.5-0.5
Delay disc. indifference point, 16s delay0.20.30.5-0.4-0.3-0.40.50.5-0.5-0.70.7
Delay disc. indifference point, 2s delay0.40.50.8-0.6-0.5-0.60.80.7-0.7-0.80.9
Delay disc. indifference point, 24s delay0.20.21.20.61.10.5-0.3-0.2-0.0-0.10.1
Delay disc. indifference point, 4s delay0.30.31.40.71.20.5-0.2-0.2-0.1-0.10.2
Delay disc. indifference point, 8s delay0.10.20.70.50.90.4-0.1-0.2-0.1-0.10.2
Indifference point function ln k0.10.20.9-0.7-0.9-0.50.40.3-0.1-0.20.3
Indifference point function log k0.10.20.9-0.7-0.9-0.50.40.3-0.1-0.20.3
Patch foraging total patch changes 0 sec0.10.20.30.2-0.10.3-0.6-0.40.50.4-0.5
Patch foraging total patch changes 12 sec1.11.51.8-1.2-1.1-1.31.21.3-1.3-1.31.0
Patch foraging total patch changes 18 sec0.40.91.4-1.1-1.2-1.10.81.0-0.9-0.80.6
Patch foraging total patch changes 24 sec0.20.71.2-1.0-1.1-0.90.60.8-0.6-0.50.6
Patch foraging total patch changes 6 sec0.20.30.30.50.60.5-0.6-0.50.40.3-0.6
Patch foraging time to switch 0 sec0.41.42.41.00.61.0-1.2-1.11.21.4-1.6
Patch foraging water rate 0 sec0.93.44.1-2.0-1.9-1.92.01.8-1.7-1.61.8
Patch foraging water rate 12 sec0.83.45.1-2.1-2.3-2.02.01.7-1.5-1.21.8
Patch foraging water rate 18 sec2.35.26.2-2.5-2.5-2.42.52.3-2.0-1.82.3
Patch foraging water rate 24 sec2.13.04.2-1.9-2.1-1.91.81.7-1.5-1.21.4
Patch foraging water rate 6 sec3.55.28.4-2.6-2.9-2.52.32.2-1.9-1.51.9
Seeking ratio, delayed vs. immediate footshock0.10.10.3-0.4-0.6-0.30.10.2-0.10.1-0.0
Distance traveled before self-admin0.91.94.8-1.8-2.2-1.61.31.3-0.9-0.60.6
Distance traveled after self-admin0.91.63.0-1.5-1.7-1.41.31.2-0.9-0.71.0
Extensor digitorum longus weight0.10.51.2-0.8-1.1-0.80.70.6-0.4-0.50.7
Bone: elastic displacement0.00.00.1-0.1-0.0-0.00.10.00.0-0.20.2
Bone: elastic work0.20.30.5-0.6-0.5-0.50.40.4-0.3-0.70.7
Bone: endosteal estimation0.41.11.7-0.9-0.5-1.01.11.2-1.3-1.20.9
Bone: endosteal perimeter0.61.52.8-1.0-0.7-1.21.21.4-1.7-1.31.0
Epididymis fat weight4.623.127.75.35.35.1-5.0-4.94.44.1-4.2
Delta time in closed arm before/after self-admin1.21.12.21.31.51.2-1.0-1.00.70.6-0.8
Delta time in open arm before/after self-admin1.41.72.8-1.5-1.7-1.41.31.2-1.0-0.91.2
Diff in mean of infusions in LGA sessions8.114.518.94.24.44.1-3.9-3.83.33.3-3.5
Delay discount exponential model param0.10.10.6-0.5-0.8-0.40.20.2-0.00.1-0.1
Extinction: sum of active levers before priming1.11.63.20.7-0.00.9-1.1-1.31.61.8-1.6
Active lever presses in extinction session 60.30.31.00.3-0.10.3-0.2-0.50.61.0-0.6
Bone: final force3.65.86.9-2.6-2.5-2.62.42.6-2.4-2.12.0
Bone: final moment3.65.86.9-2.6-2.5-2.62.42.5-2.3-2.12.0
Food consumed during 24 hour testing period0.20.40.7-0.6-0.5-0.60.50.6-0.6-0.80.5
Glucose0.50.71.1-0.7-0.5-0.81.10.9-1.0-0.91.0
Heart weight1.21.92.8-1.4-1.2-1.31.21.3-1.3-1.71.5
Delay discount hyperbolic model param0.10.10.5-0.4-0.7-0.30.10.10.10.2-0.2
Intermittent access intake day 1-15 change1.05.49.5-2.8-3.1-2.62.32.2-1.9-1.41.9
Intermittent access intake escalation0.95.08.3-2.6-2.9-2.52.22.2-1.8-1.31.8
Intermittent access intake escalation 21.62.76.2-2.1-2.5-2.01.41.6-1.3-0.80.8
Intermitt. access day 1 inactive lever presses0.10.91.61.11.31.1-0.7-1.00.90.6-0.2
Intermitt. access day 15 inactive lever presses0.00.10.20.20.10.3-0.2-0.40.40.4-0.2
Intermitt. access escalation Index0.31.12.0-0.50.1-0.71.11.1-1.4-1.31.2
Intermittent access day 1 total infusions0.10.40.50.70.50.7-0.5-0.70.70.5-0.4
Intermittent access day 15 total infusions0.71.72.4-1.4-1.6-1.41.51.2-1.0-0.91.4
Intermittent access terminal intake (last 3 days)1.32.33.6-1.7-1.9-1.61.61.4-1.1-1.01.5
Intermittent access total infusions0.50.61.0-0.8-0.9-0.80.90.6-0.5-0.61.0
Intermittent access day 1 locomotion2.03.64.41.91.62.0-1.9-2.12.12.0-1.7
Intermittent access day 15 total locomotion0.00.10.7-0.4-0.8-0.30.1-0.10.30.20.0
Intermittent access total locomotion0.10.10.40.1-0.20.2-0.2-0.50.60.6-0.2
Intermittent access standard deviation0.21.35.2-1.5-2.3-1.30.60.7-0.10.20.2
Left kidney weight0.22.02.1-1.5-1.3-1.41.41.4-1.4-1.41.4
Right kidney weight0.74.95.9-2.4-2.4-2.42.22.2-2.0-2.01.9
Cocaine induced anxiety0.10.10.60.50.80.4-0.2-0.30.10.1-0.1
Post-drug Anxiety0.50.50.7-0.8-0.8-0.80.70.8-0.7-0.50.6
Baseline Anxiety0.81.43.2-1.5-1.8-1.40.91.1-0.8-0.70.6
Tail length1.05.36.1-2.2-1.7-2.22.52.4-2.4-2.42.5
Length with tail0.62.83.6-1.6-1.3-1.71.71.8-1.9-1.71.6
Length without tail0.52.63.1-1.7-1.5-1.71.71.7-1.7-1.41.5
Times rat made contact with spout5.25.97.02.62.52.5-2.6-2.42.32.2-2.3
Lifetime Intake0.30.30.6-0.6-0.8-0.50.70.4-0.2-0.40.6
Liver weight, left0.20.41.3-0.8-1.2-0.70.60.5-0.20.00.4
Liver weight, right0.00.10.20.20.10.3-0.2-0.30.40.4-0.1
Locomotor activity1.82.75.1-2.0-2.3-1.91.41.6-1.3-1.31.1
Locomotor testing distance3.07.411.4-3.1-3.4-3.02.62.7-2.3-2.22.1
Locomotor testing rearing1.86.712.8-3.1-3.6-2.92.62.4-1.9-1.72.0
Locomotion in novel chamber1.52.12.71.51.61.5-1.6-1.41.31.0-1.4
Locomotion in novel chamber post-restriction0.30.81.4-1.1-1.2-1.00.90.9-0.7-0.60.6
Fecal boli incidents, locomotor time 10.00.10.4-0.4-0.6-0.40.20.3-0.2-0.0-0.1
Change in fecal boli incidents, locomotor task0.10.10.10.1-0.00.2-0.2-0.30.40.3-0.3
Time >=10cm from walls, locomotor time 10.20.20.8-0.6-0.9-0.50.30.3-0.1-0.00.1
Bouts of movement, locomotor time 11.31.72.01.41.41.4-1.4-1.31.31.1-0.9
Total resting periods, locomotor time 11.01.11.51.21.21.2-1.1-1.11.00.8-0.7
Rest time, locomotor task time 10.71.22.01.31.41.2-1.2-1.10.90.7-0.8
Distance moved, locomotor task time 10.71.93.4-1.6-1.8-1.51.41.3-1.1-1.01.0
Vertical activity count, locomotor time 10.00.30.8-0.7-0.9-0.60.50.4-0.3-0.20.2
Time >=10cm from walls, locomotor time 20.10.40.90.3-0.20.4-0.6-0.60.90.9-0.9
Bouts of movement, locomotor time 20.31.01.21.00.91.0-1.1-1.01.10.9-0.9
Total resting periods, locomotor time 20.20.91.11.00.91.0-1.0-1.01.00.8-0.8
Rest time, locomotor task time 20.10.10.40.40.60.3-0.3-0.20.0-0.1-0.1
Distance moved, locomotor task time 20.30.31.1-0.7-1.1-0.60.50.4-0.1-0.10.4
Vertical activity count, locomotor time 20.10.30.60.3-0.10.4-0.6-0.60.80.7-0.7
Light reinforcement 10.31.52.2-1.0-0.6-1.11.21.4-1.5-1.41.4
Light reinforcement 20.81.82.7-0.9-0.4-1.11.41.4-1.6-1.71.7
Bone: marrow area0.51.11.8-0.9-0.6-1.01.11.2-1.3-1.20.9
Bone: maximum diameter0.81.62.2-1.2-1.2-1.41.31.4-1.5-1.10.8
Bone: maximum force2.85.67.1-2.7-2.7-2.62.32.5-2.2-2.01.8
Bone: maximum moment3.05.67.5-2.7-2.7-2.62.42.4-2.2-1.91.9
Mean time between licks in bursts0.00.10.60.1-0.10.1-0.4-0.20.20.2-0.8
Mean num. licks in bursts0.51.22.91.31.71.3-1.0-1.00.80.7-0.4
Cd content in liver0.00.00.10.10.10.2-0.2-0.20.20.2-0.1
Co content in liver0.20.20.9-0.20.1-0.20.40.3-0.4-0.90.7
Cu content in liver0.91.11.6-0.9-0.7-1.01.21.0-1.1-1.01.3
Fe content in liver0.40.51.1-0.5-0.2-0.50.70.6-0.7-1.01.0
K content in liver0.60.60.9-0.7-0.4-0.70.90.9-1.0-0.80.7
Mg content in liver1.41.52.0-1.2-1.0-1.21.41.3-1.4-1.21.1
Mn content in liver10.011.213.4-3.2-2.8-3.43.73.5-3.6-3.33.2
Na content in liver3.64.04.6-2.1-2.1-2.22.12.1-2.0-1.81.6
Rb content in liver1.41.62.1-1.2-0.9-1.21.41.3-1.4-1.21.4
Se content in liver1.41.72.41.10.71.2-1.3-1.41.51.5-1.5
Sr content in liver0.20.20.5-0.5-0.7-0.40.40.2-0.1-0.00.3
Zn content in liver0.50.60.80.70.50.7-0.8-0.80.80.9-0.8
Bone: minimum diameter0.40.81.1-1.0-1.1-1.00.80.9-0.9-0.50.6
Time in familiar zone, hab. session 10.10.10.50.40.70.3-0.1-0.1-0.1-0.10.0
Time in novel zone, hab. session 10.91.11.70.60.10.8-1.1-1.11.31.3-1.3
Total zone transitions, hab. session 10.81.21.8-1.3-1.4-1.21.11.1-0.9-0.80.8
Total locomotion distance, hab. session 11.72.52.9-1.6-1.5-1.61.71.6-1.5-1.51.6
Locomotion velocity, hab. session 11.42.02.5-1.5-1.3-1.41.61.4-1.4-1.31.5
Time in familiar zone, hab. session 21.72.03.41.71.91.6-1.4-1.41.11.0-1.1
Time in novel zone, hab. session 20.70.72.3-1.1-1.5-1.00.70.7-0.4-0.30.3
Total zone transitions, hab. session 20.50.71.3-1.0-1.1-1.00.80.8-0.7-0.50.5
Total locomotion distance, hab. session 20.91.21.4-1.1-1.0-1.11.21.1-1.1-1.01.1
Locomotion velocity, hab. session 20.70.91.1-1.0-0.9-1.01.11.0-1.0-0.91.0
Novel to familiar place preference ratio1.52.02.81.20.71.3-1.5-1.51.71.7-1.6
Novelty place preference2.02.53.61.30.71.4-1.6-1.71.91.9-1.9
Time in novel zone, NPP test2.53.04.51.30.61.5-1.8-1.82.12.1-2.1
Total zone transitions, NPP test0.00.00.1-0.1-0.1-0.20.20.2-0.20.00.1
Total locomotion distance, NPP test1.01.41.8-1.0-0.8-1.11.31.2-1.4-1.21.2
Locomotion velocity, NPP test1.42.02.8-1.2-0.8-1.31.61.5-1.7-1.51.6
Intraocular pressure0.71.12.4-1.3-1.6-1.20.91.0-0.7-0.50.4
Delta distance traveled before/after self-admin0.20.20.70.50.90.4-0.1-0.20.1-0.20.5
Delta ambulatory time before/after self-admin0.61.02.3-0.7-0.4-0.81.00.9-1.0-1.21.5
Parametrial fat weight2.96.97.52.72.52.7-2.5-2.72.62.7-2.5
Pavlov. Cond. lever latency0.60.81.10.80.50.8-0.9-0.90.91.1-1.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.1-0.1-0.00.1-0.00.1-0.1
Pavlov. Cond. change in total contacts1.41.51.7-1.3-1.1-1.31.31.3-1.3-1.21.2
Pavlov. Cond. index score0.40.40.5-0.7-0.7-0.70.70.7-0.7-0.60.5
Pavlov. Cond. latency score0.40.50.6-0.7-0.5-0.70.70.8-0.7-0.70.7
Pavlov. Cond. lever contacts0.80.91.1-1.0-0.8-1.01.01.0-1.0-1.00.9
Pavlov. Cond. magazine entry number0.40.50.60.70.60.7-0.7-0.80.70.6-0.6
Pavlov. Cond. intertrial magazine entries1.21.42.0-1.2-0.9-1.11.21.2-1.2-1.31.4
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.7-0.7-0.70.60.7-0.7-0.50.5
Pavlov. Cond. response bias0.50.60.8-0.8-0.6-0.80.80.9-0.9-0.80.7
Pavlov. Cond. lever latency0.20.21.00.61.00.5-0.2-0.30.1-0.40.3
Pavlov. Cond. magazine entry latency2.12.93.31.81.71.8-1.7-1.71.61.8-1.6
Pavlov. Cond. change in total contacts0.00.10.3-0.2-0.5-0.2-0.0-0.00.10.4-0.4
Pavlov. Cond. index score0.71.12.00.90.60.9-1.1-1.01.01.4-1.3
Pavlov. Cond. latency score0.91.52.21.20.91.1-1.3-1.21.11.5-1.4
Pavlov. Cond. lever contacts0.10.20.8-0.5-0.9-0.50.20.3-0.10.3-0.3
Pavlov. Cond. magazine entry number2.73.54.0-2.0-1.9-1.91.91.8-1.6-2.01.9
Pavlov. Cond. intertrial magazine entries3.06.58.0-2.4-1.8-2.52.62.7-2.8-2.82.7
Pavlov. Cond. lever-magazine prob. diff.0.81.32.11.00.71.0-1.2-1.11.11.4-1.4
Pavlov. Cond. response bias0.20.31.00.1-0.40.2-0.4-0.40.61.0-0.9
Time in closed arm before self-admin0.20.41.0-0.30.1-0.30.50.5-0.7-1.01.0
Time in closed arm after self-admin0.20.20.80.50.90.4-0.1-0.1-0.2-0.40.3
Time in open arm before self-admin4.35.36.02.42.42.4-2.3-2.32.12.2-2.3
Time in open arm after self-admin0.70.81.40.5-0.00.6-1.0-0.91.11.2-1.2
Bone: periosteal estimation1.53.64.2-2.0-1.9-2.11.92.0-2.0-1.71.4
Bone: periosteal perimeter1.32.63.2-1.7-1.6-1.81.61.8-1.8-1.41.1
Bone: post-yield work0.50.91.7-1.2-1.3-1.10.90.9-0.7-0.60.6
Progressive ratio test 1 active lever presses0.61.01.9-1.2-1.4-1.11.10.9-0.7-0.70.7
Progressive ratio test 1 breakpoint0.61.01.9-1.2-1.4-1.11.10.9-0.7-0.70.7
Progressive ratio test 1 inactive lever presses0.00.10.20.1-0.20.1-0.1-0.30.40.4-0.5
Progressive ratio test 2 active lever presses0.40.60.9-0.7-0.7-0.80.90.8-0.8-0.70.7
Progressive ratio test 2 breakpoint0.50.70.9-0.8-0.7-0.81.00.8-0.8-0.70.8
Progressive ratio test 2 inactive lever presses0.31.11.5-1.0-0.8-1.01.21.0-1.0-1.11.2
Incentive Sensitization - Responses0.30.91.6-0.5-0.0-0.71.11.0-1.3-1.31.2
Incentive Sensitization - Breakpoint0.40.91.5-0.6-0.1-0.71.11.0-1.2-1.21.2
Sum of active levers in priming session hrs 5-64.64.35.22.01.62.1-2.1-2.22.32.3-2.1
Progressive ratio0.10.30.7-0.6-0.8-0.60.70.5-0.40.00.4
Food seeking constrained by brief footshock0.10.10.3-0.20.0-0.30.50.4-0.5-0.30.3
Seeking ratio, punishment vs. effort0.10.20.50.50.70.5-0.4-0.30.2-0.1-0.1
Retroperitoneal fat weight3.415.218.24.34.24.2-3.9-4.03.73.5-3.4
Reaction time number correct0.10.30.7-0.1-0.70.0-0.3-0.40.70.9-0.7
Reaction time mean minus median0.42.52.91.61.61.7-1.7-1.61.51.4-1.5
Reaction time mean minus median AUC0.63.74.92.12.22.1-2.0-1.91.71.5-1.6
Reaction time num false alarms1.52.62.7-1.6-1.5-1.71.51.6-1.6-1.61.6
Reaction time num false alarms AUC1.32.93.1-1.8-1.7-1.81.71.7-1.6-1.71.7
Reaction time trials correct on left0.10.30.7-0.1-0.70.0-0.3-0.40.70.9-0.7
Reaction time trials on left0.10.30.7-0.1-0.70.0-0.3-0.40.70.9-0.7
Reaction time mean0.71.52.91.51.71.4-1.2-1.21.00.8-0.7
Reaction time mean AUC0.92.14.01.72.01.7-1.4-1.51.20.9-0.9
Median of all reaction times0.40.61.81.01.30.9-0.7-0.70.50.3-0.2
Reaction time omissions1.01.72.01.41.41.3-1.4-1.21.11.2-1.3
Reaction time false alarm rate1.82.53.6-1.4-1.0-1.51.61.6-1.8-1.91.9
Reaction time premature initiation rate0.30.40.80.70.70.7-0.9-0.60.60.4-0.5
Reaction time premature initiations0.10.40.70.40.20.5-0.8-0.60.80.6-0.7
Std. dev. reaction times0.72.32.71.61.61.6-1.6-1.61.51.3-1.3
Reaction time trials completed0.10.30.7-0.1-0.70.0-0.3-0.40.70.9-0.7
Reaction time trials AUC0.10.21.2-0.6-1.1-0.40.20.10.30.4-0.2
Run reversals in cocaine runway, females0.00.00.1-0.1-0.1-0.0-0.4-0.10.2-0.2-0.2
Run reversals in cocaine runway, males0.30.31.10.41.10.20.10.2-0.6-0.70.4
Latency to leave start box in cocaine runway0.30.41.20.81.10.7-0.5-0.50.20.2-0.2
Latency to leave start box in cocaine runway, F0.30.41.00.81.00.7-0.6-0.50.30.4-0.4
Latency to leave start box in cocaine runway, M0.20.20.60.50.80.5-0.3-0.30.1-0.00.1
Std. dev. time between licks in bursts0.81.52.4-1.4-1.6-1.41.31.3-1.1-1.00.7
Total sessions with >9 infusions0.10.10.3-0.1-0.5-0.0-0.2-0.20.50.4-0.4
Short access day 1 total inactive lever presses0.30.60.80.80.80.9-0.8-0.90.90.6-0.4
Short access day 10 total inactive lever presses0.00.30.50.60.70.6-0.5-0.60.60.6-0.3
Short access day 1 total infusions0.00.10.4-0.2-0.5-0.2-0.10.10.10.2-0.6
Short access day 10 total infusions0.40.61.0-0.8-0.9-0.70.90.5-0.3-0.61.0
Short access total infusions0.10.10.30.1-0.20.2-0.2-0.40.50.4-0.5
Short access day 1 locomotion0.40.61.20.50.10.6-0.8-0.91.11.1-0.7
Short access day 10 total locomotion0.00.10.20.40.40.4-0.2-0.40.40.20.1
Short access total locomotion0.40.61.10.60.30.7-0.8-0.91.01.0-0.7
One hour access (0.3 mA shock)1.51.72.6-1.4-1.3-1.31.61.2-1.1-1.11.4
Compulsive drug intake4.36.49.32.93.02.9-2.4-2.72.42.1-1.5
One hour access (shock baseline)1.95.06.6-2.5-2.6-2.52.32.3-2.1-1.81.6
Social response proportion0.91.13.11.41.81.2-1.0-0.80.50.6-0.6
Social responses1.72.23.1-1.2-0.8-1.41.71.6-1.8-1.61.6
Social time0.30.50.80.80.90.8-0.6-0.80.60.6-0.5
Soleus weight0.00.00.1-0.2-0.2-0.20.30.2-0.1-0.10.3
Bone: stiffness3.46.17.7-2.7-2.8-2.72.62.6-2.4-1.91.9
Tibialis anterior weight0.20.50.70.80.80.8-0.7-0.80.80.5-0.3
Time to tail flick, vehicle, before self-admin2.73.34.02.01.91.9-1.7-1.81.71.8-1.8
Time to tail flick, vehicle, after self-admin2.24.55.02.22.02.2-2.1-2.22.12.2-1.8
Time to tail flick, test, before self-admin0.50.61.4-0.30.2-0.40.70.7-0.8-1.21.1
Time to tail flick, test, after self-admin0.10.10.20.2-0.00.2-0.2-0.40.50.4-0.0
Delta time to tail flick, vehicle, before/after SA0.70.81.0-1.0-1.0-0.90.90.9-0.7-0.70.9
Delta time to tail flick, test, before/after SA1.31.62.41.10.71.2-1.3-1.31.51.5-1.3
Tibia length7.320.424.1-4.4-3.6-4.54.94.7-4.7-4.54.7
Ambulatory time before self-admin0.41.34.5-1.5-2.1-1.30.90.9-0.5-0.10.1
Ambulatory time after self-admin0.50.81.4-1.0-1.2-1.00.90.9-0.7-0.50.8
Bone: tissue strength0.70.71.3-1.0-1.1-0.90.70.8-0.6-0.70.7
Total heroin consumption4.65.58.42.01.32.1-2.3-2.42.62.9-2.7
Bone: trabecular number0.20.30.8-0.6-0.3-0.50.40.6-0.6-0.90.6
Bone: trabecular spacing0.71.11.71.00.91.0-1.0-1.00.91.2-1.3
Bone: trabecular thickness1.21.71.9-1.4-1.3-1.31.31.3-1.2-1.21.3
Bone: trabecular tissue density0.10.10.4-0.4-0.7-0.40.30.3-0.20.1-0.2
Water consumed over 24 hours0.10.10.2-0.4-0.5-0.40.30.4-0.3-0.20.2
Number of responses in last shaping day1.11.51.7-1.3-1.2-1.31.21.3-1.1-1.11.2