Hub : Genes

Fam193a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Fam193a	0.11	0.08	1.2e-03	0.12	0.06	0.08	0.06	9.8e-04	1.8e-02	5.3e-03	1.6e-02
2	OFC	gene expression	Fam193a	0.08	0.06	8.7e-03	0.06	0.09	0.06	0.05	2.0e-02	3.9e-03	1.8e-02	2.1e-02
3	Adipose	gene expression	Fam193a	0.03	0.03	2.8e-04	0.02	0.03	0.02	0.02	2.3e-03	2.5e-04	1.7e-03	1.3e-03
4	pVTA	gene expression	Fam193a	0.06	0.05	1.5e-04	0.04	0.05	0.03	0.05	5.4e-04	8.7e-05	1.8e-03	8.5e-05
5	PL	gene expression	Fam193a	0.2	0.15	6.7e-10	0.06	0.07	0.06	0.07	2.4e-07	6.8e-08	7.4e-07	7.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.9	1.5	1.9	-0.9	-1.4	1.4	-1.0	-1.3
Area under the delay curve	0.3	0.3	0.5	0.7	0.5	-0.7	0.5	0.3
BMI with tail	2.2	7.5	10.8	1.8	3.1	-3.3	1.7	3.3
BMI without tail	1.6	5.0	8.6	1.4	2.6	-2.6	1.0	2.9
Body weight	6.0	26.3	31.0	4.9	5.5	-5.6	4.9	4.7
Weight adjusted by age	2.5	3.8	4.8	1.8	2.1	-2.2	1.7	1.8
Bone surface	0.3	0.5	1.2	1.1	0.2	-0.2	1.0	-0.4
Bone volume	0.1	0.1	0.2	0.2	-0.3	0.3	0.1	-0.5
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.4	-0.2	0.2	-0.4	-0.0
Number of licking bursts	1.3	2.1	3.6	1.9	1.3	-1.2	1.7	0.8
Context. condit. distance diff. score	0.2	0.3	0.7	-0.4	-0.5	0.5	-0.8	-0.3
Locomotion velocity, session 1	1.2	1.3	1.6	-1.1	-1.2	1.3	-1.3	-0.9
Locomotion distance, session 1	0.5	0.6	0.7	-0.8	-0.8	0.8	-0.6	-0.7
Locomotion velocity, session 2	5.4	6.2	8.5	-1.9	-2.8	2.9	-2.2	-2.6
Locomotion distance, session 2	2.9	4.1	5.1	-1.8	-2.3	2.1	-1.7	-2.1
Locomotion velocity, session 3	0.2	0.2	0.6	0.1	-0.5	0.4	-0.0	-0.8
Locomotion distance, session 3	0.0	0.0	0.1	0.3	0.0	-0.1	0.0	0.0
Stereotopy head waving bouts, day 3	1.5	1.7	4.5	-1.7	-0.7	0.8	-2.1	0.3
Stereotopy head waving duration, day 3	1.3	1.5	3.8	-1.7	-0.6	0.7	-1.9	0.3
Locomotion velocity, session 7	1.5	1.7	4.4	2.1	0.8	-0.7	1.7	0.0
Locomotion distance, session 7	0.3	0.4	0.9	0.6	-0.5	0.4	0.3	-1.0
Stereotopy head waving bouts, day 7	1.3	1.5	3.3	0.4	1.4	-1.4	0.1	1.8
Stereotopy head waving duration, day 7	2.1	2.6	4.0	1.1	1.8	-1.9	0.8	2.0
Locomotion velocity, session 8	1.5	1.8	2.6	-0.8	-1.6	1.6	-1.0	-1.5
Locomotion distance, session 8	2.0	2.9	3.6	-1.3	-1.9	1.9	-1.8	-1.5
Degree of sensitization distance	1.0	1.0	1.8	-0.3	-1.2	1.3	-0.4	-1.4
Degree of sensitization stereotypy	2.0	2.1	3.0	1.0	1.7	-1.7	0.9	1.7
Conditioned locomotion	0.3	0.3	0.8	0.7	0.2	-0.5	0.9	-0.3
Cocaine response after cond. corrected	1.5	1.9	2.9	-1.7	-1.3	1.2	-1.7	-0.8
Cocaine response after cond. not corrected	0.6	0.7	1.3	-1.0	-0.8	0.7	-1.1	-0.5
Cocaine response before conditioning	0.9	1.1	2.0	1.4	0.9	-0.8	1.3	0.6
Saline control response	0.2	0.2	0.3	-0.3	-0.5	0.6	-0.5	-0.4
Bone: connectivity density	0.5	0.9	1.4	-0.5	-1.1	1.0	-0.6	-1.2
Bone: cortical apparent density	0.5	0.6	1.7	-0.3	0.7	-0.8	-0.5	1.3
Bone: cortical area	6.1	9.3	13.8	3.7	3.0	-2.9	3.1	2.3
Bone: cortical porosity	0.3	0.4	0.5	-0.5	-0.7	0.7	-0.6	-0.6
Bone: cortical porosity	0.0	0.0	0.2	-0.0	-0.2	0.1	-0.5	0.0
Bone: cortical thickness	4.1	6.8	9.6	3.1	2.6	-2.6	2.2	2.3
Bone: cortical thickness	0.1	0.1	0.2	-0.0	0.3	-0.5	0.3	0.1
Bone: cortical tissue density	0.5	0.7	1.8	-0.5	0.7	-0.8	-0.6	1.3
Condit. Reinf. active minus inactive responses	1.4	1.5	2.7	-1.6	-1.1	1.1	-1.5	-0.6
Condit. Reinf. active-inactive response ratio	3.2	3.5	5.1	-2.3	-1.8	1.8	-2.1	-1.2
Condit. Reinf. active responses	0.5	0.6	1.2	-1.1	-0.7	0.6	-1.0	-0.3
Condit. Reinf. inactive responses	1.3	1.6	2.1	1.5	1.2	-1.2	1.5	0.8
Incentive salience index mean	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.4	-0.1
Condit. Reinf. lever presses	0.7	1.0	1.6	0.9	1.0	-1.0	1.3	0.6
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	1.0	0.6	-0.5	0.9	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.2	-0.1
Condit. Reinf. active responses	0.1	0.1	0.3	0.4	-0.3	0.4	0.3	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.1	-0.4	0.5	-0.1	-0.5
Condit. Reinf. lever presses	0.3	0.5	0.7	0.8	0.7	-0.7	0.6	0.6
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	0.6	-0.0	0.0	0.5	-0.3
Conditioned reinforcement - actives	0.4	0.6	0.9	0.8	0.8	-0.9	0.8	0.6
Conditioned reinforcement - inactives	0.6	0.8	0.9	1.0	0.9	-1.0	1.0	0.7
Conditioned locomotion	1.1	1.4	1.7	1.2	1.2	-1.3	1.2	1.0
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.2	0.1	0.0	-0.4	0.4
Patch foraging indifference point AUC	0.3	0.4	0.6	-0.8	-0.6	0.7	-0.7	-0.4
Delay disc. indifference point, 0s delay	0.6	0.6	1.2	0.9	0.7	-1.1	0.7	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.4	-0.3	0.2	-0.4	-0.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.2	-0.0	-0.2	0.0	-0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	0.5	0.4	-0.6	0.3	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.3	-0.5
Delay disc. indifference point, 8s delay	0.8	1.0	1.2	1.1	1.0	-1.0	1.0	0.8
Indifference point function ln k	0.2	0.3	0.4	-0.3	-0.6	0.7	-0.5	-0.5
Indifference point function log k	0.2	0.3	0.4	-0.3	-0.6	0.7	-0.5	-0.5
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	-0.2	0.2	-0.1	-0.4	0.5
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	0.5	0.7	-0.7	0.6	0.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.5	0.1	-0.0	-0.3	0.4
Patch foraging total patch changes 24 sec	0.1	0.2	0.5	0.0	0.3	-0.4	-0.5	0.7
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.2	0.3	-0.1	-0.3	0.6
Patch foraging time to switch 0 sec	0.9	1.9	2.8	1.3	1.5	-1.7	1.2	1.2
Patch foraging water rate 0 sec	0.2	0.3	0.7	0.8	0.5	-0.2	0.8	0.3
Patch foraging water rate 12 sec	0.1	0.3	0.8	-0.5	-0.2	0.4	-0.9	0.3
Patch foraging water rate 18 sec	0.1	0.2	0.7	-0.1	0.3	-0.1	-0.5	0.9
Patch foraging water rate 24 sec	0.3	0.4	1.2	0.2	0.7	-0.4	0.2	1.1
Patch foraging water rate 6 sec	0.8	1.1	1.9	1.0	1.2	-0.9	0.7	1.4
Seeking ratio, delayed vs. immediate footshock	2.5	3.1	3.7	-1.8	-1.8	1.9	-1.9	-1.4
Distance traveled before self-admin	1.0	1.4	1.7	-1.1	-1.3	1.2	-1.0	-1.2
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.1	-0.3
Extensor digitorum longus weight	2.4	9.3	11.9	2.4	3.5	-3.3	2.5	3.4
Bone: elastic displacement	0.9	1.0	1.7	1.0	1.0	-1.0	1.3	0.6
Bone: elastic work	3.5	4.5	5.1	2.1	2.3	-2.1	2.2	1.9
Bone: endosteal estimation	1.0	2.3	4.4	2.1	1.2	-1.1	2.1	0.4
Bone: endosteal perimeter	1.1	2.3	4.6	2.0	1.2	-1.1	2.2	0.5
Epididymis fat weight	2.0	6.8	8.2	2.5	2.8	-2.9	2.7	2.2
Delta time in closed arm before/after self-admin	0.8	0.8	1.1	-0.9	-0.9	0.8	-1.0	-0.7
Delta time in open arm before/after self-admin	1.7	1.7	2.1	1.4	1.3	-1.4	1.5	1.0
Diff in mean of infusions in LGA sessions	1.0	1.2	1.4	-1.1	-1.2	1.0	-1.1	-1.0
Delay discount exponential model param	0.2	0.2	0.4	-0.6	-0.4	0.6	-0.4	-0.2
Extinction: sum of active levers before priming	0.8	0.9	1.2	0.9	1.0	-1.1	1.0	0.7
Active lever presses in extinction session 6	0.0	0.0	0.1	0.1	0.2	-0.3	-0.0	0.1
Bone: final force	5.5	8.7	15.6	4.0	2.7	-2.7	3.1	2.0
Bone: final moment	4.4	7.1	13.0	3.6	2.5	-2.4	2.6	1.9
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.1	-0.2	0.4	-0.1	-0.1
Glucose	0.2	0.3	0.8	0.9	-0.2	0.3	0.7	-0.6
Heart weight	1.2	1.8	2.7	1.7	1.3	-1.2	1.5	0.9
Delay discount hyperbolic model param	0.2	0.2	0.3	-0.6	-0.4	0.6	-0.4	-0.2
Intermittent access intake day 1-15 change	2.5	5.1	5.7	-2.3	-2.4	2.3	-2.3	-1.9
Intermittent access intake escalation	1.7	3.4	3.8	-1.9	-2.0	1.9	-1.9	-1.6
Intermittent access intake escalation 2	2.7	3.1	3.6	-1.8	-1.9	1.9	-1.8	-1.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.6	-0.8	-0.7	0.8	-0.8	-0.6
Intermitt. access day 15 inactive lever presses	0.4	0.8	0.9	-0.9	-0.9	1.0	-0.9	-0.7
Intermitt. access escalation Index	0.7	1.0	1.1	-1.0	-1.1	1.1	-1.0	-0.9
Intermittent access day 1 total infusions	0.8	1.2	1.7	1.1	1.1	-1.3	1.1	0.8
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.3
Intermittent access total infusions	0.1	0.1	0.2	0.4	0.4	-0.4	0.4	0.2
Intermittent access day 1 locomotion	0.6	0.8	1.0	0.9	0.9	-1.0	0.9	0.7
Intermittent access day 15 total locomotion	0.2	0.3	0.5	0.6	0.6	-0.7	0.6	0.4
Intermittent access total locomotion	0.0	0.0	0.0	0.1	0.1	-0.2	0.1	0.1
Intermittent access standard deviation	0.3	0.7	0.7	-0.8	-0.9	0.9	-0.8	-0.7
Left kidney weight	4.3	20.0	23.6	4.4	4.9	-4.8	3.9	4.5
Right kidney weight	3.4	15.4	18.7	3.6	4.3	-4.3	3.4	3.9
Cocaine induced anxiety	0.5	0.7	0.9	-0.8	-0.9	1.0	-0.8	-0.7
Post-drug Anxiety	0.1	0.2	0.2	-0.4	-0.4	0.3	-0.4	-0.4
Baseline Anxiety	1.8	2.1	3.1	1.4	1.5	-1.8	1.4	1.1
Tail length	0.8	3.2	3.9	2.0	1.8	-1.7	1.9	1.5
Length with tail	3.5	15.3	18.5	4.1	4.0	-3.9	4.3	3.1
Length without tail	3.1	9.9	13.0	3.2	3.2	-3.2	3.6	2.4
Times rat made contact with spout	1.1	1.2	1.8	-0.9	-1.2	1.3	-1.1	-1.0
Lifetime Intake	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.3
Liver weight, left	0.6	1.0	1.6	1.3	0.9	-0.9	1.0	0.7
Liver weight, right	2.8	5.0	6.5	1.6	2.6	-2.5	1.8	2.5
Locomotor activity	0.1	0.2	0.6	0.8	0.1	0.2	0.7	-0.2
Locomotor testing distance	0.6	1.0	1.2	1.1	1.0	-0.9	1.0	0.9
Locomotor testing rearing	1.0	2.0	2.4	1.6	1.5	-1.3	1.5	1.2
Locomotion in novel chamber	0.5	0.7	1.2	-0.7	-0.8	0.8	-1.1	-0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.1	-0.4	0.2	-0.1	-0.5
Fecal boli incidents, locomotor time 1	0.4	0.5	0.6	-0.8	-0.7	0.8	-0.8	-0.5
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	-0.4	-0.7	0.8	-0.6	-0.6
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.6	1.3	1.4	-1.6	1.3	1.0
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.2	0.5	-0.6	0.2	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.3	0.5	-0.6	0.2	0.5
Rest time, locomotor task time 1	1.6	2.0	2.4	1.5	1.4	-1.3	1.5	1.2
Distance moved, locomotor task time 1	0.1	0.2	0.5	-0.4	-0.3	0.3	-0.7	-0.0
Vertical activity count, locomotor time 1	0.6	1.4	1.7	-1.2	-1.3	1.3	-1.2	-1.0
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.4	0.9	0.9	-1.0	1.2	0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.3	0.0
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.0	0.3	-0.3	0.1	0.3
Rest time, locomotor task time 2	1.1	1.4	1.9	1.2	1.2	-1.1	1.4	1.0
Distance moved, locomotor task time 2	0.5	0.6	0.8	-0.8	-0.8	0.8	-0.9	-0.6
Vertical activity count, locomotor time 2	1.5	2.0	2.4	-1.3	-1.5	1.5	-1.3	-1.4
Light reinforcement 1	1.8	4.4	5.4	1.9	2.3	-2.3	1.8	2.2
Light reinforcement 2	2.5	3.8	4.5	1.9	2.1	-2.0	1.7	1.9
Bone: marrow area	1.0	2.1	4.1	2.0	1.1	-1.0	2.0	0.3
Bone: maximum diameter	3.7	6.9	7.9	2.8	2.8	-2.7	2.3	2.6
Bone: maximum force	3.8	6.7	11.0	3.3	2.5	-2.4	2.7	1.8
Bone: maximum moment	2.9	5.2	8.7	2.9	2.2	-2.1	2.2	1.8
Mean time between licks in bursts	0.8	1.8	2.8	-1.2	-1.5	1.7	-1.2	-1.2
Mean num. licks in bursts	2.9	4.5	5.9	-2.4	-2.1	2.1	-2.3	-1.5
Cd content in liver	0.1	0.1	0.3	-0.0	-0.3	0.4	0.2	-0.5
Co content in liver	0.5	0.6	1.7	1.3	0.3	-0.4	1.0	-0.2
Cu content in liver	1.0	1.1	1.6	-0.6	-1.3	1.2	-0.9	-1.2
Fe content in liver	3.4	4.2	5.4	-1.4	-2.3	2.2	-2.2	-2.0
K content in liver	0.1	0.1	0.2	0.4	-0.0	-0.1	0.4	-0.4
Mg content in liver	1.2	1.2	1.4	1.1	1.1	-1.2	1.2	0.8
Mn content in liver	0.4	0.4	0.9	-0.3	-0.8	0.8	-0.2	-0.9
Na content in liver	0.3	0.3	0.9	0.5	-0.6	0.4	-0.0	-0.9
Rb content in liver	0.3	0.4	1.3	1.1	0.3	-0.4	0.7	0.0
Se content in liver	0.4	0.4	1.1	-0.9	-0.1	0.1	-1.1	0.5
Sr content in liver	1.9	1.7	2.0	1.3	1.4	-1.3	1.1	1.4
Zn content in liver	0.4	0.4	1.1	-0.6	0.4	-0.2	-0.7	1.0
Bone: minimum diameter	1.5	2.7	6.0	2.4	1.3	-1.2	2.1	0.6
Time in familiar zone, hab. session 1	0.9	0.8	1.7	-0.9	-0.9	0.9	-1.3	-0.4
Time in novel zone, hab. session 1	0.4	0.4	0.6	0.2	0.8	-0.7	0.6	0.7
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.3	-0.5	0.5	-0.2	-0.6
Total locomotion distance, hab. session 1	0.6	0.9	1.5	-0.6	-1.1	1.1	-0.4	-1.2
Locomotion velocity, hab. session 1	0.4	0.5	1.6	0.0	-0.8	0.7	0.2	-1.2
Time in familiar zone, hab. session 2	3.6	3.8	5.2	-2.1	-2.0	1.9	-2.3	-1.4
Time in novel zone, hab. session 2	5.8	5.9	7.2	2.1	2.7	-2.5	2.3	2.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.3	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.3	-0.0	0.1	-0.4	0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.4	0.2
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.1	-0.4	0.3	0.0	-0.6
Novelty place preference	0.0	0.0	0.1	0.0	-0.2	0.2	0.1	-0.4
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	-0.2
Total zone transitions, NPP test	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.1	-0.3
Total locomotion distance, NPP test	0.4	0.5	0.6	-0.8	-0.7	0.7	-0.7	-0.7
Locomotion velocity, NPP test	0.6	0.8	1.0	-0.9	-1.0	0.9	-0.8	-0.9
Intraocular pressure	0.2	0.3	0.7	0.3	0.7	-0.6	0.2	0.8
Delta distance traveled before/after self-admin	0.7	0.7	1.1	0.9	0.9	-1.1	0.7	0.7
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.3	-0.2
Parametrial fat weight	0.2	0.5	1.2	-0.7	-0.6	0.6	-1.1	-0.3
Pavlov. Cond. lever latency	1.0	1.2	2.1	-1.2	-1.0	1.1	-1.4	-0.6
Pavlov. Cond. magazine entry latency	0.8	1.0	1.8	-1.3	-0.9	1.0	-1.1	-0.5
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	-0.2	-0.1	0.0	0.3	-0.3
Pavlov. Cond. index score	0.0	0.1	0.1	-0.2	-0.2	0.2	0.1	-0.4
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.0	-0.0	0.3	-0.2
Pavlov. Cond. lever contacts	0.7	0.8	1.5	1.1	0.7	-0.8	1.2	0.3
Pavlov. Cond. magazine entry number	1.1	1.4	1.9	1.4	1.2	-1.2	1.2	1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	0.2	0.7	-0.7	-0.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2	-0.3
Pavlov. Cond. response bias	0.1	0.2	0.2	-0.5	-0.4	0.4	-0.3	-0.4
Pavlov. Cond. lever latency	0.4	0.6	0.9	0.4	0.9	-0.9	0.6	0.8
Pavlov. Cond. magazine entry latency	1.3	1.5	1.8	1.1	1.3	-1.3	1.2	1.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.1
Pavlov. Cond. lever contacts	0.8	1.1	1.5	-0.8	-1.2	1.2	-0.8	-1.1
Pavlov. Cond. magazine entry number	1.7	2.1	2.5	-1.4	-1.6	1.5	-1.4	-1.4
Pavlov. Cond. intertrial magazine entries	0.7	1.1	1.6	-0.8	-1.2	1.2	-0.6	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	0.2	-0.2	0.2	0.2
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.0	-0.3
Time in closed arm before self-admin	0.1	0.1	0.1	0.3	0.3	-0.3	0.4	0.3
Time in closed arm after self-admin	0.4	0.4	0.6	-0.7	-0.6	0.6	-0.8	-0.4
Time in open arm before self-admin	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	0.3
Time in open arm after self-admin	1.6	1.8	2.3	1.5	1.3	-1.3	1.5	1.0
Bone: periosteal estimation	3.6	7.7	13.0	3.6	2.5	-2.4	3.3	1.6
Bone: periosteal perimeter	4.1	7.1	10.9	3.3	2.5	-2.5	3.2	1.5
Bone: post-yield work	0.5	0.8	1.3	-1.1	-0.8	0.9	-1.1	-0.4
Progressive ratio test 1 active lever presses	0.8	1.1	1.2	1.1	1.1	-1.1	1.1	0.8
Progressive ratio test 1 breakpoint	0.8	1.0	1.2	1.0	1.1	-1.1	1.0	0.8
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.3	0.5	0.5	-0.5	0.5	0.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.2	0.2	-0.3	0.2	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.2	0.2	-0.3	0.2	0.1
Progressive ratio test 2 inactive lever presses	0.3	0.6	0.7	0.8	0.8	-0.8	0.8	0.5
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.2	0.0	-0.1	-0.2	0.0
Progressive ratio	0.1	0.2	0.4	0.6	0.4	-0.4	0.6	0.2
Food seeking constrained by brief footshock	1.5	1.8	3.7	1.2	1.3	-1.4	1.9	0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	0.0	0.0	0.3	-0.1
Retroperitoneal fat weight	0.4	1.9	2.4	1.5	1.4	-1.6	1.3	1.0
Reaction time number correct	0.4	0.8	1.9	0.6	1.0	-0.7	0.5	1.4
Reaction time mean minus median	0.7	1.7	2.1	-1.4	-1.3	1.3	-1.3	-1.1
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.1	0.3	-0.4	0.0	0.4
Reaction time num false alarms	1.0	1.5	2.2	1.2	1.2	-1.5	1.1	1.0
Reaction time num false alarms AUC	1.5	2.4	3.5	1.4	1.7	-1.9	1.2	1.5
Reaction time trials correct on left	0.4	0.8	1.9	0.6	1.0	-0.7	0.5	1.4
Reaction time trials on left	0.4	0.7	1.7	0.5	1.0	-0.6	0.3	1.3
Reaction time mean	0.9	1.5	1.8	-1.1	-1.3	1.2	-1.2	-1.2
Reaction time mean AUC	0.8	1.4	1.7	-1.1	-1.3	1.1	-1.1	-1.2
Median of all reaction times	0.8	1.1	1.4	-0.8	-1.2	1.0	-0.9	-1.2
Reaction time omissions	0.6	0.9	1.8	-1.3	-0.7	0.7	-1.3	-0.2
Reaction time false alarm rate	0.7	1.0	2.0	0.9	1.0	-1.4	0.8	0.8
Reaction time premature initiation rate	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.2	0.5
Reaction time premature initiations	0.3	0.5	1.4	0.1	0.8	-0.6	-0.1	1.2
Std. dev. reaction times	0.5	1.0	1.4	-1.2	-1.0	0.9	-1.2	-0.6
Reaction time trials completed	0.4	0.7	1.7	0.5	1.0	-0.6	0.3	1.3
Reaction time trials AUC	0.3	0.6	1.5	0.4	0.9	-0.5	0.3	1.2
Run reversals in cocaine runway, females	0.9	0.9	1.2	-1.0	-1.1	0.8	-0.9	-1.1
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.1	0.5	-0.6	0.8	0.3
Latency to leave start box in cocaine runway	1.2	1.4	1.9	1.4	1.2	-1.2	1.1	0.9
Latency to leave start box in cocaine runway, F	2.6	3.0	3.5	1.8	1.8	-1.9	1.7	1.4
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.3	-0.1	0.1	-0.2	0.1
Std. dev. time between licks in bursts	0.3	0.4	0.9	0.1	-0.6	0.7	0.2	-1.0
Total sessions with >9 infusions	0.1	0.1	0.1	0.4	0.3	-0.4	0.4	0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	0.1
Short access day 10 total inactive lever presses	0.5	1.1	1.6	-1.1	-1.1	1.3	-1.1	-0.7
Short access day 1 total infusions	0.0	0.0	0.1	0.2	0.2	-0.3	0.2	0.1
Short access day 10 total infusions	0.0	0.0	0.0	0.1	0.0	-0.0	0.1	0.0
Short access total infusions	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	-0.1
Short access day 1 locomotion	0.4	0.5	0.6	0.7	0.7	-0.8	0.7	0.5
Short access day 10 total locomotion	1.3	2.4	2.8	-1.6	-1.6	1.7	-1.6	-1.2
Short access total locomotion	0.5	0.6	0.7	-0.8	-0.8	0.8	-0.8	-0.6
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.2	0.2	-0.1	0.2	0.1
Compulsive drug intake	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	-0.3
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.2	-0.1	0.2	0.1
Social response proportion	1.4	1.6	2.1	-1.4	-1.2	1.4	-1.4	-0.7
Social responses	0.1	0.1	0.2	-0.2	0.1	0.2	-0.3	0.4
Social time	1.2	1.7	2.0	-1.2	-1.4	1.4	-1.1	-1.3
Soleus weight	2.2	6.6	10.3	1.9	3.0	-2.7	1.8	3.2
Bone: stiffness	1.4	2.3	5.1	2.2	1.0	-1.1	2.0	0.2
Tibialis anterior weight	1.3	4.4	5.7	1.6	2.4	-2.3	1.8	2.3
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.0	-0.8	-0.7	0.6	-1.0	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.5	0.7	-0.8	-0.7	0.6	-0.9	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.2	0.3	-0.2	0.2	0.3
Time to tail flick, test, after self-admin	0.3	0.3	0.5	0.6	0.6	-0.4	0.7	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.3	0.3	-0.2	0.3	0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.0	0.2	-0.0	0.0
Tibia length	1.7	4.6	10.9	3.3	1.7	-1.7	2.3	0.9
Ambulatory time before self-admin	0.5	0.8	1.0	-0.9	-1.0	0.9	-0.7	-1.0
Ambulatory time after self-admin	0.8	0.9	1.2	-1.0	-1.1	0.9	-0.9	-1.0
Bone: tissue strength	1.4	1.4	2.3	1.5	1.2	-0.9	1.0	1.2
Total heroin consumption	0.4	0.5	0.6	0.6	0.8	-0.7	0.6	0.7
Bone: trabecular number	0.4	0.6	1.1	-0.9	-0.8	0.7	-1.0	-0.4
Bone: trabecular spacing	1.5	2.1	3.3	1.8	1.3	-1.3	1.7	0.9
Bone: trabecular thickness	1.1	1.4	2.2	-1.5	-1.2	1.2	-1.0	-1.1
Bone: trabecular tissue density	0.2	0.3	0.9	0.0	-0.7	0.6	-0.1	-0.9
Water consumed over 24 hours	1.1	1.4	2.4	-0.9	-1.3	1.6	-1.0	-1.1
Number of responses in last shaping day	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.0	-0.2