Hub : Genes

Fam13b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Fam13b 0.73 0.21 5.4e-04 0.11 0.13 0.27 0.18 1.0e-02 5.6e-03 4.6e-05 1.0e-03
2 Liver gene expression Fam13b 0.17 0.08 0.0e+00 0.13 0.15 0.14 0.14 1.7e-14 1.2e-16 5.2e-15 2.0e-15
3 Adipose mRNA stability Fam13b 0.13 0.06 0.0e+00 0.15 0.16 0.15 0.14 1.7e-16 6.5e-17 7.2e-16 8.3e-16
4 Brain isoform ratio XM_039096734.1 0.08 0.05 3.3e-09 0.11 0.1 0.09 0.1 2.7e-10 1.4e-09 1.1e-08 1.8e-09
5 Liver isoform ratio XM_039096734.1 0.03 0.02 1.4e-04 0.03 0.02 0.01 0.03 1.4e-04 1.9e-03 1.2e-02 5.5e-04
6 Liver alternative TSS XM_039096734.1 0.03 0.02 1.6e-04 0.02 0.02 0.01 0.02 1.5e-03 1.7e-03 1.3e-02 1.7e-03
7 Adipose isoform ratio XM_039096734.1 0.03 0.02 2.9e-03 0.02 0.02 0.01 0.02 1.2e-03 1.8e-03 1.4e-02 3.0e-03
8 pVTA intron excision ratio chr18_26060061_26061333 0.08 0.06 4.9e-03 0.02 0.03 0.01 0.03 3.1e-02 1.6e-02 7.7e-02 2.2e-02
9 Brain alternative TSS XM_039096734.1 0.07 0.04 2.1e-08 0.09 0.09 0.09 0.09 9.4e-09 8.4e-09 1.6e-08 2.2e-08
10 Adipose gene expression Fam13b 0.15 0.08 0.0e+00 0.17 0.16 0.16 0.17 1.0e-18 1.4e-17 6.4e-17 4.5e-18
11 PL isoform ratio XM_039096734.1 0.02 0.02 7.9e-03 0.02 0.02 0.01 0.02 2.7e-03 4.9e-03 1.2e-02 6.9e-03
12 Adipose intron excision ratio chr18_26065107_26067320 0.03 0.02 2.5e-03 0.02 0.01 0.02 0.01 1.6e-03 9.1e-03 2.5e-03 1.0e-02
13 PL alternative TSS XM_039096734.1 0.03 0.02 1.1e-03 0.03 0.03 0.02 0.02 7.2e-04 5.9e-04 3.2e-03 1.5e-03
14 pVTA intron excision ratio chr18_26060061_26064187 0.06 0.05 9.1e-03 0.04 0.04 0.03 0.04 1.1e-02 1.0e-02 2.7e-02 8.4e-03
15 RMTg mRNA stability Fam13b 0.15 0.1 5.6e-04 0.05 0.12 0.13 0.1 1.8e-02 3.1e-04 2.6e-04 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.61.04.31.4-0.3-0.70.31.01.01.02.0-0.10.40.4-0.50.1-2.10.7
Area under the delay curve4.04.35.70.6-1.7-2.32.22.42.32.31.6-2.22.42.4-1.9-2.2-1.32.2
BMI with tail6.220.029.9-5.25.55.0-5.2-4.1-4.1-4.1-4.24.5-4.5-4.54.44.23.6-3.4
BMI without tail4.59.314.2-3.83.73.4-3.6-2.9-2.9-2.9-3.02.9-3.0-3.03.22.72.3-2.3
Body weight6.025.041.0-5.56.45.6-6.0-4.5-4.5-4.5-3.65.4-5.5-5.55.15.22.7-3.4
Weight adjusted by age1.92.23.8-1.91.71.5-1.2-1.5-1.6-1.6-1.51.2-1.7-1.71.61.01.3-0.8
Bone surface1.12.05.12.1-0.8-1.10.61.71.71.72.3-0.51.11.1-1.4-0.2-2.20.7
Bone volume0.91.54.51.9-0.6-0.80.31.51.51.52.1-0.20.80.8-1.10.1-2.10.6
Breakpoint value in progressive ratio session0.10.10.20.10.10.1-0.1-0.4-0.4-0.40.30.3-0.3-0.30.40.3-0.5-0.2
Number of licking bursts1.01.22.41.5-1.3-1.10.81.51.51.50.8-1.00.90.9-1.0-0.8-0.40.4
Context. condit. distance diff. score0.10.10.3-0.0-0.0-0.1-0.00.50.50.5-0.2-0.2-0.0-0.0-0.2-0.10.30.2
Locomotion velocity, session 10.60.62.31.10.20.9-0.8-0.7-0.8-0.8-0.01.1-0.3-0.30.31.2-0.4-1.5
Locomotion distance, session 10.00.00.10.1-0.10.1-0.10.10.10.1-0.20.1-0.1-0.10.20.10.2-0.3
Locomotion velocity, session 20.70.92.3-0.90.71.1-1.0-0.8-0.8-0.8-1.50.8-0.4-0.40.60.71.4-1.1
Locomotion distance, session 20.40.61.00.6-1.0-0.80.71.01.01.00.4-0.80.90.9-0.8-0.7-0.10.5
Locomotion velocity, session 30.20.20.5-0.50.50.5-0.7-0.2-0.2-0.2-0.30.6-0.4-0.40.20.60.3-0.3
Locomotion distance, session 30.30.30.9-0.30.1-0.40.20.70.70.70.9-0.2-0.1-0.1-0.0-0.1-0.91.0
Stereotopy head waving bouts, day 32.32.75.00.9-1.6-1.61.71.71.71.71.1-1.62.22.2-2.2-1.6-0.81.3
Stereotopy head waving duration, day 30.40.41.6-0.4-0.5-0.30.60.10.10.1-0.6-0.61.31.3-1.0-0.70.70.2
Locomotion velocity, session 70.30.41.3-0.91.10.5-0.7-0.0-0.0-0.00.60.7-0.4-0.40.30.7-0.90.5
Locomotion distance, session 70.50.72.7-0.50.3-0.60.20.80.80.81.5-0.30.10.1-0.4-0.3-1.61.6
Stereotopy head waving bouts, day 70.70.81.8-0.80.50.8-0.4-1.2-1.2-1.2-1.40.4-0.5-0.50.70.31.4-0.8
Stereotopy head waving duration, day 70.60.73.8-0.5-0.10.5-0.0-0.8-0.8-0.8-1.8-0.0-0.1-0.10.3-0.21.9-0.8
Locomotion velocity, session 80.60.74.1-0.7-0.00.6-0.3-0.6-0.7-0.7-1.90.10.30.3-0.1-0.12.0-1.0
Locomotion distance, session 80.10.10.20.2-0.3-0.20.10.50.50.5-0.2-0.20.30.3-0.3-0.20.30.1
Degree of sensitization distance0.20.20.8-0.90.80.3-0.4-0.4-0.4-0.4-0.10.3-0.4-0.40.20.2-0.00.3
Degree of sensitization stereotypy0.70.83.2-0.40.00.6-0.1-1.1-1.1-1.1-1.70.1-0.5-0.50.7-0.01.8-0.9
Conditioned locomotion0.20.20.9-0.10.5-0.0-0.30.40.40.41.00.3-0.1-0.1-0.20.4-1.00.6
Cocaine response after cond. corrected0.60.71.40.50.60.8-1.0-0.6-0.6-0.6-0.01.0-1.1-1.10.91.2-0.2-1.0
Cocaine response after cond. not corrected0.20.21.51.2-0.50.0-0.10.00.00.0-0.20.1-0.6-0.60.40.20.2-0.7
Cocaine response before conditioning3.84.68.51.6-2.9-2.52.52.22.22.20.0-2.92.02.0-2.0-2.90.91.4
Saline control response0.40.61.51.0-1.2-1.01.20.60.70.70.1-1.1-0.1-0.10.2-1.10.30.5
Bone: connectivity density1.92.97.02.7-1.5-1.61.31.81.71.72.3-1.11.61.6-1.8-0.8-2.21.0
Bone: cortical apparent density0.71.02.30.7-1.4-1.21.50.70.70.70.2-1.31.01.0-0.9-1.30.10.8
Bone: cortical area2.63.96.41.6-1.7-2.21.82.52.52.52.3-1.81.31.3-1.7-1.7-2.02.1
Bone: cortical porosity0.70.71.2-0.20.81.0-0.9-0.9-1.0-1.0-0.41.1-0.9-0.90.71.10.0-1.1
Bone: cortical porosity0.50.50.9-0.10.60.8-0.8-0.8-0.8-0.8-0.40.9-0.8-0.80.60.90.1-0.9
Bone: cortical thickness2.03.35.60.8-1.2-2.01.72.42.42.42.0-1.81.31.3-1.7-1.7-1.62.3
Bone: cortical thickness0.30.41.00.2-0.2-0.70.40.90.90.91.0-0.50.10.1-0.3-0.4-0.90.9
Bone: cortical tissue density0.60.82.00.6-1.3-1.01.40.60.60.60.1-1.20.90.9-0.8-1.20.20.7
Condit. Reinf. active minus inactive responses2.42.74.51.6-1.7-1.71.71.61.61.61.4-1.52.12.1-2.1-1.4-1.21.2
Condit. Reinf. active-inactive response ratio1.31.42.30.1-0.9-1.31.31.21.21.20.8-1.31.41.4-1.3-1.3-0.51.5
Condit. Reinf. active responses2.63.29.83.1-2.1-1.61.51.81.81.82.0-1.11.81.8-2.0-0.8-1.90.5
Condit. Reinf. inactive responses1.92.310.63.3-1.8-1.10.91.41.41.42.0-0.51.11.1-1.3-0.2-2.1-0.1
Incentive salience index mean1.82.24.42.1-1.9-1.51.71.31.31.31.2-1.31.81.8-1.6-1.2-1.00.7
Condit. Reinf. lever presses0.91.33.71.9-1.7-1.31.50.80.80.80.9-1.20.80.8-0.7-1.1-0.90.5
Condit. Reinf. active minus inactive responses2.93.612.33.5-2.9-2.12.31.41.41.41.6-1.91.51.5-1.6-1.7-1.20.7
Condit. Reinf. active-inactive response ratio0.50.53.21.8-0.50.00.2-0.6-0.6-0.60.80.3-0.3-0.30.30.5-1.0-0.6
Condit. Reinf. active responses6.79.319.84.3-4.4-3.63.72.72.72.71.9-3.52.72.7-2.7-3.3-1.11.7
Condit. Reinf. inactive responses7.28.915.92.8-4.0-3.53.53.13.13.11.2-3.62.92.9-2.9-3.6-0.32.0
Condit. Reinf. lever presses2.02.76.72.6-2.3-1.81.71.71.71.71.6-1.51.11.1-1.4-1.3-1.30.8
Condit. Reinf. lever reinforcers received6.28.719.24.2-4.4-3.43.72.62.62.61.6-3.42.72.7-2.7-3.2-0.91.4
Conditioned reinforcement - actives0.30.31.31.2-0.70.0-0.0-0.4-0.4-0.4-0.3-0.1-0.3-0.30.3-0.00.4-1.0
Conditioned reinforcement - inactives0.10.10.60.8-0.3-0.40.20.20.20.20.6-0.20.20.2-0.1-0.1-0.50.1
Conditioned locomotion0.20.21.61.3-0.9-0.30.20.30.30.30.2-0.3-0.0-0.0-0.1-0.2-0.1-0.7
Patch foraging indifference point 0 sec1.83.05.31.1-2.2-2.12.01.91.91.90.4-2.31.51.5-1.3-2.30.11.3
Patch foraging indifference point AUC3.03.54.82.1-2.0-2.12.11.61.61.61.9-1.82.22.2-1.7-1.6-1.81.5
Delay disc. indifference point, 0s delay1.41.62.80.2-0.8-1.41.31.51.41.41.3-1.31.41.4-0.7-1.3-1.01.7
Delay disc. indifference point, 16s delay4.84.96.70.7-1.9-2.42.32.62.52.51.5-2.42.42.4-2.5-2.4-1.12.3
Delay disc. indifference point, 2s delay0.80.81.7-0.3-0.2-0.90.81.00.90.91.3-0.71.11.1-0.4-0.7-1.31.3
Delay disc. indifference point, 24s delay0.90.81.20.3-0.5-0.90.71.01.01.01.0-0.81.01.0-1.0-0.8-0.91.1
Delay disc. indifference point, 4s delay0.80.92.40.6-0.6-1.00.90.70.60.61.4-0.81.11.1-0.6-0.7-1.61.0
Delay disc. indifference point, 8s delay5.35.57.50.9-2.0-2.62.52.72.72.71.9-2.52.52.5-2.2-2.5-1.32.5
Indifference point function ln k8.111.315.6-3.33.43.5-3.6-3.4-3.4-3.4-3.13.1-3.9-3.93.62.92.8-2.7
Indifference point function log k8.111.315.6-3.33.43.5-3.6-3.4-3.4-3.4-3.13.1-3.9-3.93.62.92.8-2.7
Patch foraging total patch changes 0 sec1.93.05.31.4-2.3-2.02.01.92.02.00.5-2.21.61.6-1.4-2.2-0.01.1
Patch foraging total patch changes 12 sec8.911.515.23.1-3.9-3.83.73.83.83.82.1-3.73.63.6-3.2-3.5-1.42.7
Patch foraging total patch changes 18 sec5.46.911.72.7-2.3-2.82.32.82.82.83.4-2.12.62.6-2.5-1.9-3.32.3
Patch foraging total patch changes 24 sec2.93.54.61.3-1.9-2.22.02.12.12.11.4-2.11.91.9-1.7-2.0-1.11.8
Patch foraging total patch changes 6 sec3.55.27.12.4-2.6-2.72.52.42.42.42.0-2.52.22.2-1.7-2.3-1.61.9
Patch foraging time to switch 0 sec0.10.10.3-0.50.40.4-0.3-0.1-0.1-0.1-0.40.3-0.2-0.20.10.30.1-0.3
Patch foraging water rate 0 sec0.00.00.00.10.1-0.1-0.1-0.0-0.0-0.00.1-0.0-0.1-0.10.1-0.00.10.2
Patch foraging water rate 12 sec0.50.82.30.01.10.8-1.2-0.5-0.5-0.50.21.0-1.5-1.50.91.1-0.5-0.5
Patch foraging water rate 18 sec0.30.40.80.7-0.00.4-0.4-0.7-0.7-0.7-0.60.4-0.8-0.80.90.40.5-0.9
Patch foraging water rate 24 sec0.30.52.81.7-0.10.5-0.5-0.3-0.4-0.40.10.7-0.5-0.50.40.9-0.3-1.2
Patch foraging water rate 6 sec0.20.20.70.80.20.2-0.50.10.10.10.60.5-0.5-0.50.10.7-0.8-0.3
Seeking ratio, delayed vs. immediate footshock0.50.51.70.9-1.3-0.71.00.90.90.9-0.1-0.80.20.2-0.1-0.80.4-0.0
Distance traveled before self-admin0.50.52.7-0.60.4-0.40.4-0.2-0.2-0.21.4-0.10.40.4-0.6-0.1-1.61.2
Distance traveled after self-admin0.91.04.22.0-1.4-1.11.10.20.30.31.7-0.70.60.6-0.1-0.5-1.60.4
Extensor digitorum longus weight2.07.912.3-3.53.32.9-2.9-2.7-2.7-2.7-2.52.6-3.2-3.23.22.42.1-1.7
Bone: elastic displacement1.31.42.6-0.80.91.3-1.0-1.4-1.4-1.4-1.61.0-1.0-1.01.20.91.5-1.2
Bone: elastic work2.12.75.0-1.21.11.6-1.3-1.7-1.7-1.7-2.21.2-1.8-1.82.01.12.1-1.6
Bone: endosteal estimation0.61.22.11.3-1.2-1.00.71.41.41.40.7-0.91.31.3-1.3-0.8-0.50.5
Bone: endosteal perimeter0.10.20.40.7-0.6-0.40.30.60.60.60.2-0.40.50.5-0.6-0.4-0.10.0
Epididymis fat weight4.19.513.8-2.12.63.5-3.1-3.2-3.2-3.2-3.73.0-2.9-2.92.92.83.2-3.4
Delta time in closed arm before/after self-admin3.33.27.3-1.21.11.9-1.5-1.8-1.9-1.9-2.71.4-1.4-1.41.21.22.7-2.3
Delta time in open arm before/after self-admin1.21.23.5-0.30.2-0.90.60.80.90.91.8-0.51.11.1-1.2-0.4-1.81.9
Diff in mean of infusions in LGA sessions1.01.12.80.40.81.0-1.1-0.7-0.8-0.80.31.3-1.7-1.71.21.4-0.6-1.0
Delay discount exponential model param4.24.45.8-0.71.72.3-2.2-2.4-2.4-2.4-1.92.2-2.4-2.42.02.21.5-2.3
Extinction: sum of active levers before priming0.40.42.10.20.40.2-0.2-0.4-0.4-0.41.20.6-0.4-0.4-0.10.7-1.40.1
Active lever presses in extinction session 62.12.03.71.4-1.4-1.61.31.81.71.71.9-1.20.90.9-1.1-1.0-1.61.3
Bone: final force1.21.92.81.2-1.3-1.51.31.71.71.71.4-1.31.31.3-1.4-1.2-1.11.2
Bone: final moment0.61.11.51.2-1.0-1.10.91.21.21.21.1-0.90.90.9-1.0-0.8-0.90.8
Food consumed during 24 hour testing period1.21.43.0-0.81.71.1-1.6-0.5-0.5-0.50.71.5-1.3-1.31.31.7-1.1-0.4
Glucose6.810.214.7-2.03.43.5-3.5-3.5-3.4-3.4-1.73.5-3.7-3.73.83.50.8-2.8
Heart weight3.04.29.1-2.43.02.1-2.5-1.7-1.6-1.6-0.32.4-2.5-2.52.42.40.0-0.6
Delay discount hyperbolic model param3.84.05.3-0.81.62.2-2.0-2.3-2.2-2.2-1.92.0-2.3-2.31.82.01.7-2.1
Intermittent access intake day 1-15 change0.50.52.3-0.70.60.6-0.7-0.5-0.5-0.5-1.10.4-0.5-0.50.10.41.5-0.5
Intermittent access intake escalation0.20.21.0-0.30.30.3-0.5-0.2-0.2-0.2-0.60.2-0.3-0.3-0.00.21.0-0.3
Intermittent access intake escalation 20.30.30.9-0.90.80.5-0.7-0.5-0.5-0.5-0.40.4-0.5-0.50.40.40.8-0.1
Intermitt. access day 1 inactive lever presses0.10.10.50.7-0.20.10.00.10.20.2-0.00.2-0.1-0.10.00.30.2-0.6
Intermitt. access day 15 inactive lever presses0.10.20.30.4-0.10.2-0.40.40.40.4-0.30.2-0.5-0.50.50.30.5-0.6
Intermitt. access escalation Index1.11.01.4-0.40.91.2-1.0-1.0-1.0-1.0-0.81.2-1.0-1.01.11.20.6-1.0
Intermittent access day 1 total infusions0.70.83.82.0-1.7-0.50.60.60.60.6-0.9-0.70.30.3-0.3-0.70.9-1.2
Intermittent access day 15 total infusions0.70.73.11.8-1.4-0.30.30.50.50.5-1.0-0.50.20.2-0.3-0.51.4-1.2
Intermittent access terminal intake (last 3 days)0.50.52.70.9-1.1-0.20.20.30.40.4-1.2-0.60.00.0-0.1-0.61.6-0.8
Intermittent access total infusions0.60.62.51.6-1.20.10.10.00.00.0-1.2-0.2-0.2-0.20.3-0.11.2-1.6
Intermittent access day 1 locomotion0.60.63.51.9-1.20.10.1-0.1-0.1-0.1-0.9-0.1-0.2-0.20.2-0.01.0-1.6
Intermittent access day 15 total locomotion2.62.87.20.30.71.7-1.7-1.3-1.4-1.4-1.91.5-2.0-2.01.91.61.7-2.7
Intermittent access total locomotion1.71.96.30.7-0.01.2-1.1-1.2-1.2-1.2-1.90.9-1.4-1.41.50.91.8-2.5
Intermittent access standard deviation0.40.41.30.3-0.20.3-0.1-1.0-1.0-1.0-1.00.10.30.3-0.2-0.01.1-0.8
Left kidney weight0.20.61.5-0.11.00.7-1.0-0.1-0.1-0.10.71.1-1.1-1.11.01.2-0.7-0.4
Right kidney weight0.20.51.4-0.50.80.6-0.90.00.10.1-0.20.7-1.2-1.21.20.80.4-0.4
Cocaine induced anxiety0.30.31.50.40.40.4-0.5-0.5-0.5-0.50.80.7-0.1-0.10.10.8-1.2-0.3
Post-drug Anxiety0.40.52.30.3-0.0-0.40.20.70.70.71.4-0.00.20.2-0.40.1-1.50.7
Baseline Anxiety0.50.51.3-0.8-0.3-0.70.61.11.11.10.0-0.80.30.3-0.4-0.80.41.0
Tail length0.10.20.4-0.60.50.4-0.6-0.2-0.2-0.2-0.60.3-0.6-0.60.60.30.4-0.3
Length with tail0.72.54.8-1.72.21.6-1.9-1.3-1.4-1.4-0.41.8-2.0-2.01.71.80.0-0.5
Length without tail0.71.52.6-1.11.61.3-1.4-1.2-1.2-1.2-0.31.5-1.6-1.61.11.50.2-0.5
Times rat made contact with spout0.70.83.50.10.80.1-0.50.50.60.61.70.7-0.8-0.80.70.9-1.90.4
Lifetime Intake0.70.83.41.6-1.20.10.1-0.2-0.1-0.1-1.5-0.2-0.3-0.30.3-0.21.6-1.8
Liver weight, left0.30.52.81.7-0.80.2-0.1-0.4-0.4-0.4-0.60.1-0.4-0.40.70.20.5-1.4
Liver weight, right1.22.04.71.7-2.2-1.21.31.21.21.2-0.9-1.61.51.5-1.6-1.61.3-0.2
Locomotor activity0.40.63.4-1.90.8-0.30.20.40.50.50.8-0.20.30.3-0.6-0.3-0.81.5
Locomotor testing distance0.20.31.2-1.10.7-0.20.10.10.10.10.90.0-0.2-0.2-0.2-0.0-0.91.1
Locomotor testing rearing0.40.71.20.3-0.8-1.00.91.11.11.10.6-1.00.50.5-0.6-0.9-0.50.9
Locomotion in novel chamber0.20.31.20.3-0.60.10.2-0.1-0.0-0.0-1.0-0.20.60.6-0.6-0.31.1-0.7
Locomotion in novel chamber post-restriction0.30.31.7-1.20.50.2-0.50.10.10.1-1.0-0.1-0.0-0.0-0.3-0.21.30.4
Fecal boli incidents, locomotor time 10.30.31.00.2-0.30.30.0-0.7-0.7-0.7-1.00.0-0.1-0.10.5-0.11.0-0.9
Change in fecal boli incidents, locomotor task0.10.10.50.4-0.30.2-0.1-0.3-0.4-0.4-0.50.20.20.20.20.10.7-0.7
Time >=10cm from walls, locomotor time 10.40.41.20.10.60.7-0.3-0.7-0.5-0.50.00.8-0.7-0.71.10.90.1-0.6
Bouts of movement, locomotor time 11.61.74.41.3-1.3-1.21.52.11.91.90.6-1.20.90.9-1.1-1.1-0.30.9
Total resting periods, locomotor time 11.31.43.21.1-1.3-1.11.41.81.71.70.3-1.20.90.9-1.0-1.1-0.00.8
Rest time, locomotor task time 10.10.10.4-0.10.20.3-0.20.50.40.4-0.40.2-0.4-0.40.30.30.6-0.1
Distance moved, locomotor task time 10.20.21.0-0.50.5-0.1-0.2-0.4-0.3-0.30.70.10.10.10.00.0-1.00.6
Vertical activity count, locomotor time 10.91.02.8-1.71.50.5-0.8-1.0-1.0-1.00.90.8-0.6-0.60.80.7-1.30.7
Time >=10cm from walls, locomotor time 24.95.17.3-1.82.72.4-2.4-2.7-2.5-2.5-0.82.5-2.6-2.62.52.40.4-1.5
Bouts of movement, locomotor time 20.60.72.1-0.1-0.7-0.60.31.41.41.4-0.2-0.70.60.6-1.0-0.80.40.3
Total resting periods, locomotor time 20.40.41.6-0.3-0.3-0.30.11.31.21.2-0.2-0.40.30.3-0.7-0.40.30.2
Rest time, locomotor task time 21.01.12.7-1.61.51.2-1.2-0.5-0.5-0.5-0.61.2-1.2-1.21.11.20.5-0.4
Distance moved, locomotor task time 20.20.31.1-0.70.4-0.4-0.1-0.00.10.11.0-0.20.20.2-0.2-0.2-1.10.9
Vertical activity count, locomotor time 20.50.52.5-0.60.4-0.50.20.00.00.01.5-0.20.30.3-0.2-0.2-1.61.3
Light reinforcement 11.52.84.21.3-1.8-1.91.82.02.12.11.2-1.81.61.6-1.5-1.7-0.81.4
Light reinforcement 23.54.76.71.2-1.8-2.32.42.22.22.22.1-2.12.62.6-2.2-2.0-1.92.2
Bone: marrow area0.61.22.21.1-1.2-1.00.71.51.51.50.7-0.91.31.3-1.4-0.8-0.50.5
Bone: maximum diameter2.44.36.72.2-2.2-2.31.92.62.62.62.0-1.91.81.8-2.0-1.7-1.61.5
Bone: maximum force0.30.61.20.7-0.5-0.90.70.90.90.91.1-0.60.40.4-0.4-0.6-0.90.9
Bone: maximum moment0.10.20.60.6-0.3-0.40.30.50.50.50.8-0.3-0.0-0.0-0.0-0.2-0.60.4
Mean time between licks in bursts0.20.31.3-0.20.80.6-1.20.30.30.3-0.00.8-0.2-0.20.10.90.0-0.7
Mean num. licks in bursts1.31.63.2-1.51.81.2-1.3-1.3-1.3-1.3-0.11.4-1.5-1.51.41.4-0.4-0.2
Cd content in liver0.10.10.60.8-0.6-0.10.20.00.00.0-0.3-0.10.20.2-0.5-0.10.3-0.7
Co content in liver0.30.41.20.80.30.6-0.7-0.4-0.4-0.40.40.90.00.0-0.11.1-0.7-0.9
Cu content in liver3.44.15.91.5-2.3-2.42.42.02.02.01.6-2.31.91.9-2.3-2.3-1.11.9
Fe content in liver2.12.57.30.6-0.5-1.51.21.51.51.52.7-1.01.31.3-1.5-0.9-2.72.2
K content in liver0.40.41.51.1-1.2-0.40.60.20.20.2-0.6-0.60.40.4-0.4-0.60.7-0.7
Mg content in liver1.41.54.01.7-2.0-1.21.31.21.21.2-0.1-1.41.11.1-1.2-1.40.4-0.0
Mn content in liver0.50.61.40.10.30.8-0.8-0.5-0.4-0.4-1.00.7-1.0-1.00.90.71.0-1.2
Na content in liver0.20.21.60.7-0.2-0.20.4-0.1-0.1-0.11.10.0-0.0-0.0-0.20.1-1.30.2
Rb content in liver1.82.35.12.1-2.3-1.41.11.81.81.8-0.3-1.61.41.4-1.6-1.50.9-0.3
Se content in liver0.40.51.10.2-0.4-0.60.51.01.01.00.5-0.51.01.0-1.1-0.5-0.40.6
Sr content in liver1.00.91.50.3-0.7-1.01.10.60.60.61.0-0.91.21.2-1.2-0.9-1.01.1
Zn content in liver2.52.73.51.2-1.7-1.81.91.81.81.81.4-1.61.81.8-1.7-1.6-1.11.5
Bone: minimum diameter0.81.53.41.5-1.1-1.31.01.41.41.41.8-1.00.40.4-0.8-0.8-1.71.1
Time in familiar zone, hab. session 10.30.30.7-0.50.80.4-0.7-0.2-0.1-0.10.50.6-0.6-0.60.50.7-0.70.1
Time in novel zone, hab. session 11.01.01.8-0.0-0.9-1.01.20.90.90.90.1-1.21.21.2-1.1-1.30.31.0
Total zone transitions, hab. session 11.82.65.40.21.51.8-1.8-1.7-1.7-1.7-0.02.2-1.5-1.51.72.3-0.6-1.8
Total locomotion distance, hab. session 10.50.74.22.0-0.40.20.1-0.2-0.3-0.31.30.70.20.2-0.00.9-1.8-0.6
Locomotion velocity, hab. session 10.60.96.02.5-0.50.20.1-0.4-0.4-0.41.20.80.20.20.01.0-1.7-0.9
Time in familiar zone, hab. session 23.43.65.40.7-1.5-2.11.72.32.32.31.5-2.01.81.8-2.2-1.9-1.02.3
Time in novel zone, hab. session 22.62.64.4-0.41.31.8-1.4-2.1-2.1-2.1-0.91.9-1.4-1.41.71.80.5-2.0
Total zone transitions, hab. session 20.20.20.60.20.10.4-0.4-0.3-0.3-0.3-0.40.4-0.6-0.60.80.40.3-0.6
Total locomotion distance, hab. session 20.50.62.81.7-1.0-0.60.50.80.80.80.9-0.40.40.4-0.5-0.2-0.90.0
Locomotion velocity, hab. session 20.30.42.61.6-0.7-0.30.20.50.50.50.80.00.20.2-0.20.2-1.0-0.3
Novel to familiar place preference ratio2.12.17.3-2.72.01.2-0.9-1.8-1.8-1.8-0.61.1-1.4-1.41.60.90.20.2
Novelty place preference2.52.58.3-2.92.21.4-1.0-1.9-1.9-1.9-0.81.2-1.4-1.41.71.00.40.1
Time in novel zone, NPP test2.22.28.2-2.92.11.3-0.9-1.8-1.8-1.8-0.71.1-1.3-1.31.60.90.40.2
Total zone transitions, NPP test0.20.32.61.6-0.60.1-0.2-0.0-0.0-0.00.20.3-0.2-0.20.40.5-0.4-1.0
Total locomotion distance, NPP test0.91.27.52.7-1.4-0.70.70.80.80.81.4-0.30.70.7-0.6-0.0-1.6-0.3
Locomotion velocity, NPP test1.01.48.02.8-1.6-0.90.80.90.90.91.4-0.40.80.8-0.6-0.2-1.6-0.2
Intraocular pressure3.95.410.0-3.13.22.6-2.9-2.0-2.0-2.0-1.82.5-2.2-2.22.32.41.4-1.5
Delta distance traveled before/after self-admin2.52.712.53.5-2.6-1.51.31.71.71.71.2-1.21.11.1-0.6-0.9-0.8-0.3
Delta ambulatory time before/after self-admin2.52.712.63.5-2.4-1.61.31.61.61.61.9-1.11.11.1-0.6-0.8-1.60.1
Parametrial fat weight1.12.14.6-0.40.51.2-0.9-2.1-2.1-2.1-2.10.8-1.0-1.01.20.61.9-1.7
Pavlov. Cond. lever latency0.20.21.0-1.00.3-0.30.20.30.30.30.4-0.30.30.3-0.3-0.3-0.31.0
Pavlov. Cond. magazine entry latency0.10.20.6-0.4-0.3-0.50.60.20.30.3-0.1-0.70.20.2-0.2-0.80.30.8
Pavlov. Cond. change in total contacts0.10.20.9-0.00.1-0.20.3-0.00.00.00.8-0.10.40.4-0.3-0.0-0.90.6
Pavlov. Cond. index score0.00.00.20.4-0.2-0.00.1-0.3-0.3-0.30.0-0.0-0.0-0.00.1-0.0-0.0-0.2
Pavlov. Cond. latency score0.10.10.30.4-0.10.2-0.0-0.5-0.5-0.5-0.30.2-0.1-0.10.30.20.2-0.5
Pavlov. Cond. lever contacts0.10.21.21.1-0.8-0.20.4-0.1-0.1-0.1-0.2-0.20.20.2-0.1-0.20.2-0.5
Pavlov. Cond. magazine entry number0.10.20.4-0.10.20.4-0.4-0.3-0.3-0.3-0.50.4-0.5-0.50.50.40.3-0.7
Pavlov. Cond. intertrial magazine entries0.70.94.42.1-0.7-0.40.20.50.50.51.70.20.40.4-0.20.5-2.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.00.10.20.5-0.3-0.20.3-0.0-0.0-0.00.2-0.20.20.2-0.2-0.2-0.20.1
Pavlov. Cond. response bias0.10.10.40.6-0.4-0.40.40.20.20.20.4-0.30.20.2-0.3-0.3-0.30.2
Pavlov. Cond. lever latency1.21.64.9-2.21.81.3-1.4-1.2-1.2-1.2-1.21.1-0.9-0.90.91.01.1-0.4
Pavlov. Cond. magazine entry latency0.20.20.91.0-0.5-0.30.30.40.40.40.6-0.10.50.5-0.7-0.0-0.6-0.1
Pavlov. Cond. change in total contacts1.62.24.01.9-2.0-1.61.91.21.21.21.2-1.51.61.6-1.5-1.4-1.00.9
Pavlov. Cond. index score0.70.92.91.7-1.4-0.91.10.80.80.80.8-0.81.01.0-1.1-0.7-0.70.1
Pavlov. Cond. latency score0.60.82.51.6-1.4-0.91.00.60.60.60.6-0.81.01.0-1.0-0.7-0.50.1
Pavlov. Cond. lever contacts1.21.76.62.6-2.0-1.31.31.31.31.31.0-1.10.90.9-1.0-0.9-0.80.1
Pavlov. Cond. magazine entry number1.01.32.5-1.21.61.2-1.3-1.0-1.0-1.0-0.21.3-1.4-1.41.41.2-0.1-0.5
Pavlov. Cond. intertrial magazine entries0.40.53.7-0.10.6-0.1-0.10.20.20.21.70.4-0.1-0.10.10.5-1.90.8
Pavlov. Cond. lever-magazine prob. diff.0.81.02.91.7-1.4-0.91.10.80.80.80.8-0.81.11.1-1.1-0.7-0.70.2
Pavlov. Cond. response bias2.02.76.52.5-2.3-1.81.81.71.71.71.3-1.61.41.4-1.6-1.5-1.00.6
Time in closed arm before self-admin0.80.92.3-0.91.50.8-1.1-0.6-0.6-0.60.71.1-1.0-1.01.21.2-1.00.1
Time in closed arm after self-admin1.31.32.9-1.01.31.2-1.2-1.3-1.2-1.2-0.61.2-1.2-1.21.71.20.5-0.8
Time in open arm before self-admin0.40.41.81.0-1.0-0.20.60.10.10.1-0.9-0.40.30.3-0.6-0.41.3-0.7
Time in open arm after self-admin0.40.41.10.3-0.1-0.50.20.70.70.71.1-0.20.40.4-1.0-0.1-0.90.8
Bone: periosteal estimation1.42.85.01.4-1.5-1.81.42.22.22.21.6-1.51.41.4-1.7-1.4-1.31.5
Bone: periosteal perimeter0.61.01.91.1-1.3-1.21.01.41.41.40.6-1.20.60.6-0.9-1.1-0.30.6
Bone: post-yield work0.10.10.30.5-0.4-0.40.50.10.20.20.5-0.40.10.10.0-0.3-0.40.3
Progressive ratio test 1 active lever presses0.40.42.51.6-0.60.2-0.1-0.2-0.2-0.2-0.20.3-0.4-0.40.30.40.0-1.4
Progressive ratio test 1 breakpoint0.40.42.21.5-0.70.2-0.1-0.3-0.3-0.3-0.40.3-0.4-0.40.30.40.2-1.4
Progressive ratio test 1 inactive lever presses0.50.63.31.8-1.3-0.40.60.30.30.3-0.5-0.50.50.5-0.6-0.40.7-1.0
Progressive ratio test 2 active lever presses0.70.73.51.8-0.70.5-0.3-0.5-0.4-0.4-0.50.5-0.7-0.70.70.70.3-1.9
Progressive ratio test 2 breakpoint0.70.83.61.6-0.40.7-0.5-0.7-0.7-0.7-0.30.8-0.9-0.90.80.90.1-1.9
Progressive ratio test 2 inactive lever presses0.70.94.82.2-1.00.4-0.3-0.5-0.5-0.5-0.70.3-0.5-0.50.50.50.8-2.0
Incentive Sensitization - Responses0.20.20.60.8-0.00.3-0.4-0.3-0.3-0.30.30.5-0.4-0.40.30.6-0.4-0.7
Incentive Sensitization - Breakpoint0.20.20.60.80.10.3-0.4-0.4-0.3-0.30.50.6-0.4-0.40.40.7-0.7-0.6
Sum of active levers in priming session hrs 5-63.33.26.32.3-1.8-1.92.11.11.21.22.5-1.41.81.8-1.9-1.2-2.31.7
Progressive ratio0.10.10.50.0-0.4-0.10.3-0.4-0.3-0.3-0.5-0.30.10.10.0-0.40.7-0.0
Food seeking constrained by brief footshock0.20.20.8-0.4-0.2-0.40.50.20.10.1-0.1-0.50.50.5-0.6-0.60.30.9
Seeking ratio, punishment vs. effort0.10.10.3-0.50.2-0.1-0.00.60.50.50.0-0.10.20.2-0.3-0.10.00.4
Retroperitoneal fat weight3.411.313.9-3.33.63.7-3.5-3.7-3.7-3.7-3.23.3-3.3-3.33.23.02.7-2.9
Reaction time number correct1.01.53.1-0.41.61.4-1.7-1.1-1.1-1.1-0.21.6-1.2-1.21.31.7-0.1-1.1
Reaction time mean minus median0.70.93.3-1.00.4-0.70.50.60.60.61.5-0.40.80.8-1.2-0.4-1.41.8
Reaction time mean minus median AUC0.60.73.9-0.60.8-0.2-0.1-0.0-0.1-0.11.80.30.10.1-0.80.4-2.01.3
Reaction time num false alarms0.70.92.2-0.50.91.0-0.9-1.5-1.5-1.5-0.61.0-0.6-0.60.90.90.3-0.9
Reaction time num false alarms AUC1.21.73.6-0.61.11.4-1.2-1.9-1.9-1.9-1.11.3-0.9-0.91.31.10.7-1.3
Reaction time trials correct on left1.01.53.1-0.41.61.4-1.7-1.1-1.1-1.1-0.21.6-1.2-1.21.31.7-0.1-1.1
Reaction time trials on left1.11.53.1-0.41.61.4-1.8-1.1-1.1-1.1-0.21.6-1.2-1.21.31.7-0.0-1.1
Reaction time mean0.40.63.4-1.81.20.7-0.7-0.8-0.8-0.8-0.40.6-0.3-0.3-0.30.50.20.2
Reaction time mean AUC0.20.31.9-1.40.80.4-0.4-0.6-0.6-0.6-0.30.40.00.0-0.60.20.10.3
Median of all reaction times0.91.23.3-1.81.31.2-1.1-1.4-1.4-1.4-1.20.9-0.7-0.70.30.70.9-0.6
Reaction time omissions0.10.11.3-0.2-0.1-0.20.00.20.20.2-0.1-0.30.50.5-1.1-0.30.30.1
Reaction time false alarm rate0.30.51.5-0.50.40.6-0.3-1.2-1.2-1.2-0.70.4-0.3-0.30.60.30.5-0.5
Reaction time premature initiation rate2.33.17.72.8-1.9-1.81.32.22.22.21.9-1.41.01.0-1.4-1.1-1.71.0
Reaction time premature initiations1.11.56.82.6-1.3-1.10.51.51.51.51.5-0.70.50.5-0.8-0.4-1.40.3
Std. dev. reaction times0.70.92.8-1.71.50.3-0.7-0.1-0.1-0.11.50.7-0.1-0.1-0.70.7-1.71.2
Reaction time trials completed1.11.53.1-0.41.61.4-1.8-1.1-1.1-1.1-0.21.6-1.2-1.21.31.7-0.0-1.1
Reaction time trials AUC1.11.53.1-0.51.61.4-1.8-1.1-1.1-1.1-0.11.6-1.2-1.21.31.7-0.1-1.1
Run reversals in cocaine runway, females0.60.61.1-0.6-0.5-0.70.90.70.70.7-0.0-0.90.90.9-0.9-1.00.31.0
Run reversals in cocaine runway, males0.40.42.1-0.7-0.20.00.3-0.3-0.3-0.3-1.4-0.50.40.4-0.1-0.71.50.2
Latency to leave start box in cocaine runway1.41.52.30.5-1.0-1.51.11.21.31.31.3-1.41.11.1-1.2-1.3-1.21.4
Latency to leave start box in cocaine runway, F0.80.91.50.5-0.7-1.20.61.11.21.21.1-1.10.70.7-0.7-1.0-0.81.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.4-0.1-0.10.4-0.1-0.1-0.10.1-0.20.10.1-0.1-0.3-0.50.1
Std. dev. time between licks in bursts0.10.10.70.8-0.2-0.10.10.30.20.20.4-0.00.40.4-0.20.1-0.4-0.2
Total sessions with >9 infusions1.11.23.10.20.41.1-0.8-1.4-1.4-1.4-1.20.9-1.0-1.00.70.91.0-1.8
Short access day 1 total inactive lever presses1.11.27.72.8-1.7-0.70.60.80.80.81.1-0.30.40.4-0.6-0.1-1.2-1.0
Short access day 10 total inactive lever presses0.30.41.10.5-0.4-0.50.11.01.01.00.9-0.30.20.2-0.5-0.2-0.60.4
Short access day 1 total infusions0.80.93.21.4-1.20.20.4-0.8-0.8-0.8-1.5-0.2-0.1-0.10.2-0.21.5-1.8
Short access day 10 total infusions0.20.21.61.3-0.7-0.20.2-0.0-0.0-0.00.1-0.1-0.1-0.1-0.1-0.0-0.1-0.6
Short access total infusions0.70.72.51.4-1.4-0.20.6-0.1-0.1-0.1-1.4-0.60.20.2-0.2-0.61.6-1.3
Short access day 1 locomotion1.41.53.20.90.51.2-1.1-1.6-1.6-1.6-0.41.3-1.3-1.31.11.40.2-1.8
Short access day 10 total locomotion2.32.64.0-1.01.51.7-1.6-2.0-2.0-2.0-1.71.4-1.4-1.41.51.31.7-1.6
Short access total locomotion1.31.33.00.10.31.0-0.8-1.4-1.4-1.4-1.70.7-1.0-1.00.90.71.7-1.7
One hour access (0.3 mA shock)0.50.62.40.3-0.30.4-0.4-0.5-0.5-0.5-1.50.1-0.7-0.70.90.01.6-1.2
Compulsive drug intake0.70.71.4-1.21.10.7-0.6-1.2-1.2-1.2-0.30.7-0.8-0.80.70.6-0.10.2
One hour access (shock baseline)0.40.51.81.3-1.1-0.10.10.20.20.2-0.9-0.30.10.1-0.0-0.31.2-1.3
Social response proportion1.41.54.4-2.11.01.0-1.0-1.3-1.3-1.3-2.00.5-0.5-0.50.60.22.0-0.4
Social responses0.60.71.90.3-1.4-0.91.20.10.10.1-0.3-1.11.11.1-0.7-1.30.40.6
Social time1.41.911.2-1.7-0.10.5-0.1-0.9-0.9-0.9-3.0-0.4-0.6-0.60.4-0.83.3-0.8
Soleus weight2.26.415.8-2.71.72.4-1.8-2.6-2.6-2.6-4.01.5-2.2-2.22.51.23.8-2.4
Bone: stiffness0.71.22.10.8-0.8-1.10.91.41.41.41.3-0.90.90.9-1.1-0.8-1.01.0
Tibialis anterior weight1.03.34.8-2.22.22.0-2.2-1.4-1.4-1.4-1.91.7-2.1-2.11.81.61.9-1.3
Time to tail flick, vehicle, before self-admin2.72.77.4-0.2-0.9-1.91.71.31.41.41.7-1.81.71.7-1.8-1.9-1.22.7
Time to tail flick, vehicle, after self-admin0.20.20.60.5-0.3-0.40.4-0.2-0.2-0.20.4-0.40.70.7-0.8-0.4-0.50.4
Time to tail flick, test, before self-admin0.20.20.7-0.10.30.3-0.2-0.5-0.5-0.50.40.4-0.8-0.80.70.5-0.5-0.1
Time to tail flick, test, after self-admin0.80.92.20.5-1.4-1.01.50.80.80.8-0.5-1.30.70.7-0.3-1.40.90.4
Delta time to tail flick, vehicle, before/after SA0.90.93.00.30.21.0-0.9-0.6-0.7-0.7-1.60.7-0.8-0.80.80.71.4-1.7
Delta time to tail flick, test, before/after SA0.70.63.2-0.6-0.7-0.30.70.20.20.2-1.6-0.80.50.5-0.1-1.11.8-0.1
Tibia length0.61.84.8-1.32.21.5-1.9-0.7-0.7-0.70.31.8-1.4-1.40.91.9-0.8-0.5
Ambulatory time before self-admin0.30.41.4-1.00.6-0.20.20.1-0.0-0.01.10.00.00.0-0.4-0.0-1.21.1
Ambulatory time after self-admin0.91.03.41.4-1.1-1.00.90.60.60.61.8-0.60.40.4-0.3-0.5-1.80.8
Bone: tissue strength0.10.10.20.10.30.1-0.2-0.2-0.2-0.20.40.2-0.2-0.20.00.2-0.50.2
Total heroin consumption0.20.20.8-0.30.20.2-0.2-0.9-0.9-0.9-0.20.20.30.3-0.40.00.2-0.0
Bone: trabecular number0.40.72.81.3-0.2-0.40.10.80.80.81.60.00.20.2-0.40.3-1.70.4
Bone: trabecular spacing0.30.42.1-0.4-0.3-0.10.20.30.30.3-1.2-0.50.30.3-0.4-0.61.4-0.2
Bone: trabecular thickness0.30.31.00.8-0.3-0.50.20.60.70.71.0-0.30.20.2-0.5-0.1-0.90.5
Bone: trabecular tissue density0.20.32.2-1.50.80.4-0.4-0.0-0.1-0.1-0.70.20.10.10.10.10.90.2
Water consumed over 24 hours1.41.710.60.20.8-0.4-0.30.90.90.93.00.5-0.3-0.30.00.7-3.31.3
Number of responses in last shaping day1.21.36.32.5-1.7-0.91.11.11.11.10.2-0.80.90.9-0.9-0.60.0-0.4