Hub : Genes

Ext1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ext1 0.04 0.03 1.3e-05 0.03 0.03 0.03 0.03 4.0e-05 5.0e-06 1.6e-05 1.8e-05
2 OFC mRNA stability Ext1 0.44 0.18 5.2e-06 0.13 0.21 0.22 0.16 5.3e-04 9.5e-06 6.0e-06 1.1e-04
3 IC mRNA stability Ext1 0.67 0.11 0.0e+00 0.31 0.45 0.43 0.43 1.1e-13 7.0e-21 1.4e-19 8.9e-20
4 PL mRNA stability Ext1 0.48 0.13 0.0e+00 0.34 0.42 0.43 0.43 7.5e-39 2.3e-49 2.0e-51 1.9e-51
5 OFC gene expression Ext1 0.14 0.1 3.3e-03 0.08 0.08 0.07 0.04 6.0e-03 6.0e-03 8.2e-03 4.5e-02
6 BLA mRNA stability Ext1 0.31 0.11 5.6e-17 0.25 0.26 0.26 0.26 1.1e-13 6.1e-14 5.2e-14 2.7e-14
7 Brain gene expression Ext1 0.06 0.04 7.4e-05 0.05 0.05 0.05 0.05 2.8e-05 1.5e-05 1.3e-05 1.4e-05
8 IC gene expression Ext1 0.15 0.09 4.1e-05 0.04 0.09 0.09 0.09 1.3e-02 1.3e-04 1.2e-04 1.5e-04
9 Adipose alternative polyA NM_001130540.1 0.02 0.02 4.0e-03 0.02 0.01 0.01 0.01 5.5e-03 1.6e-02 1.6e-02 1.7e-02
10 Adipose alternative polyA XM_039078770.2 0.03 0.02 9.2e-04 0.02 0.02 0.02 0.02 2.2e-03 3.0e-03 3.6e-03 5.1e-03
11 IL mRNA stability Ext1 0.23 0.13 8.1e-04 0.1 0.05 0.07 0.01 2.2e-03 2.9e-02 1.0e-02 1.7e-01
12 Brain mRNA stability Ext1 0.04 0.03 2.3e-04 0.04 0.03 0.03 0.01 2.0e-04 1.2e-03 1.1e-03 7.2e-02
13 Liver gene expression Ext1 0.06 0.04 8.6e-07 0.04 0.04 0.04 0.04 2.1e-05 1.4e-05 9.2e-06 1.9e-05
14 PL gene expression Ext1 0.02 0.02 3.8e-03 0.01 0.02 0.01 0.01 1.1e-02 4.0e-03 1.4e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.82.4-0.11.00.5-0.01.1-0.70.81.2-0.80.8-0.9-1.10.61.5
Area under the delay curve0.50.60.90.9-0.6-0.9-0.90.9-0.80.60.7-0.80.8-0.7-0.80.70.5
BMI with tail3.311.324.7-4.55.04.64.1-3.03.1-3.0-2.52.8-2.82.82.8-3.1-1.1
BMI without tail2.37.017.6-3.54.23.63.1-2.12.3-2.2-1.82.1-2.12.12.1-2.9-0.6
Body weight5.222.637.3-6.16.06.15.7-4.74.7-4.5-4.14.2-4.24.14.0-4.3-2.4
Weight adjusted by age0.60.93.0-1.51.51.71.4-1.00.8-0.7-0.60.4-0.40.40.7-0.2-0.0
Bone surface0.10.10.5-0.40.70.60.30.20.00.10.2-0.10.1-0.2-0.3-0.20.4
Bone volume0.40.72.00.10.70.2-0.21.1-0.70.81.2-0.70.7-0.9-1.00.71.4
Breakpoint value in progressive ratio session0.60.82.00.5-1.2-1.0-0.2-0.40.6-0.6-0.81.0-1.01.01.0-0.4-1.4
Number of licking bursts0.20.31.2-0.3-0.10.10.1-0.60.4-0.4-0.60.4-0.40.30.7-1.1-0.6
Context. condit. distance diff. score1.41.62.4-1.51.41.51.6-1.41.3-1.2-1.21.2-1.21.31.3-0.8-0.8
Locomotion velocity, session 10.20.20.9-0.5-0.00.60.3-0.70.4-0.0-0.60.1-0.10.10.2-0.9-0.4
Locomotion distance, session 10.10.10.5-0.40.70.50.4-0.60.3-0.3-0.4-0.00.00.1-0.1-0.3-0.3
Locomotion velocity, session 24.04.67.41.9-1.0-1.4-2.02.0-2.42.42.0-2.72.7-2.7-2.71.22.0
Locomotion distance, session 20.50.71.40.60.0-0.4-0.60.8-0.80.80.9-1.11.1-0.9-1.20.70.9
Locomotion velocity, session 33.03.45.9-2.22.42.22.0-2.11.7-1.5-2.01.2-1.21.11.4-2.4-1.4
Locomotion distance, session 32.52.74.5-1.72.11.51.7-1.71.7-1.7-1.81.5-1.51.41.3-2.0-1.4
Stereotopy head waving bouts, day 30.30.40.8-0.80.30.90.8-0.70.7-0.4-0.60.5-0.50.40.6-0.4-0.5
Stereotopy head waving duration, day 30.20.30.9-0.2-0.20.60.10.5-0.30.60.8-0.40.4-0.5-0.20.90.9
Locomotion velocity, session 70.30.30.8-0.70.80.90.7-0.10.2-0.20.10.5-0.50.40.10.90.4
Locomotion distance, session 71.51.93.3-1.41.51.31.6-0.91.5-1.6-0.71.8-1.81.81.30.6-0.5
Stereotopy head waving bouts, day 73.43.96.31.1-0.3-0.5-1.42.1-2.22.32.3-2.42.4-2.4-2.21.42.5
Stereotopy head waving duration, day 72.83.35.31.1-0.4-0.6-1.41.9-2.12.22.0-2.32.3-2.3-2.11.02.2
Locomotion velocity, session 80.10.10.2-0.40.10.40.3-0.40.3-0.3-0.30.3-0.30.30.30.0-0.3
Locomotion distance, session 80.91.43.3-1.41.81.41.4-1.21.2-1.2-1.01.0-1.01.20.9-0.5-0.6
Degree of sensitization distance0.20.22.70.0-0.40.0-0.00.3-0.0-0.00.50.2-0.20.20.01.60.3
Degree of sensitization stereotypy5.76.28.91.8-0.9-1.2-2.12.6-2.92.82.7-3.03.0-3.0-2.81.92.8
Conditioned locomotion0.20.20.4-0.40.20.20.5-0.50.5-0.5-0.60.4-0.40.60.6-0.5-0.6
Cocaine response after cond. corrected0.70.81.71.2-1.2-1.3-1.10.8-0.80.70.7-0.80.8-0.6-0.60.80.3
Cocaine response after cond. not corrected0.91.01.71.3-0.8-1.3-1.21.3-1.10.81.1-0.90.9-0.6-0.90.90.8
Cocaine response before conditioning0.20.21.2-0.21.10.40.20.5-0.20.10.50.1-0.10.3-0.2-0.10.8
Saline control response0.81.12.0-0.40.50.10.6-1.11.2-1.3-1.31.1-1.11.21.2-1.0-1.4
Bone: connectivity density0.10.20.70.10.30.1-0.20.5-0.50.60.5-0.50.5-0.6-0.8-0.10.6
Bone: cortical apparent density1.01.31.71.2-0.8-1.1-1.31.2-1.31.31.1-1.31.3-1.3-1.10.31.0
Bone: cortical area1.62.58.6-2.32.92.62.1-1.01.3-1.4-0.71.1-1.11.01.1-0.70.1
Bone: cortical porosity0.20.30.9-0.30.80.60.40.5-0.10.00.7-0.00.0-0.0-0.30.90.9
Bone: cortical porosity0.40.52.1-0.91.51.20.9-0.10.3-0.40.10.4-0.40.30.10.40.5
Bone: cortical thickness0.30.63.4-1.01.81.30.80.20.1-0.10.3-0.10.1-0.20.1-0.30.9
Bone: cortical thickness0.50.62.8-0.71.71.10.40.5-0.20.20.7-0.40.4-0.4-0.50.51.2
Bone: cortical tissue density1.11.51.91.3-0.9-1.2-1.41.3-1.41.41.2-1.41.4-1.4-1.20.31.0
Condit. Reinf. active minus inactive responses0.20.21.00.0-0.0-0.20.0-0.60.3-0.2-0.80.1-0.10.1-0.2-1.0-0.8
Condit. Reinf. active-inactive response ratio1.51.62.31.4-1.2-1.4-1.51.0-1.41.40.8-1.41.4-1.5-1.50.10.6
Condit. Reinf. active responses1.41.73.6-1.21.21.11.2-1.81.3-1.2-1.90.9-0.91.00.6-1.9-1.5
Condit. Reinf. inactive responses4.04.96.5-2.52.22.42.4-2.52.4-2.3-2.42.0-2.02.11.8-1.9-1.9
Incentive salience index mean0.60.82.0-0.70.80.60.7-1.30.8-0.8-1.40.5-0.50.50.2-1.4-1.2
Condit. Reinf. lever presses0.60.91.7-1.11.31.00.9-1.20.9-0.9-1.30.4-0.40.50.3-1.1-0.9
Condit. Reinf. active minus inactive responses1.41.93.3-1.81.61.81.5-1.31.2-1.1-1.21.2-1.21.11.0-1.7-0.8
Condit. Reinf. active-inactive response ratio1.71.93.1-1.71.51.71.7-1.21.4-1.3-1.11.5-1.51.41.1-1.3-0.8
Condit. Reinf. active responses2.63.67.2-2.62.32.72.3-1.91.7-1.5-1.61.6-1.61.51.5-2.0-0.8
Condit. Reinf. inactive responses0.30.41.1-0.90.91.10.8-0.60.4-0.3-0.40.4-0.40.40.4-0.40.0
Condit. Reinf. lever presses0.30.41.1-0.31.10.60.00.4-0.50.70.4-0.50.5-0.7-0.7-0.61.0
Condit. Reinf. lever reinforcers received2.02.86.3-2.42.22.52.1-1.61.5-1.2-1.31.4-1.41.31.2-1.7-0.6
Conditioned reinforcement - actives0.61.03.2-1.21.41.30.9-1.00.8-0.7-1.10.6-0.60.50.5-1.8-0.5
Conditioned reinforcement - inactives0.81.12.5-1.41.21.61.2-1.31.0-0.8-1.20.6-0.60.40.5-1.3-0.8
Conditioned locomotion3.44.46.2-2.21.72.02.1-2.52.2-2.1-2.51.9-1.91.82.0-2.2-2.0
Patch foraging indifference point 0 sec1.42.53.8-1.61.91.41.6-1.71.7-1.7-1.91.3-1.31.41.0-1.9-1.5
Patch foraging indifference point AUC2.33.34.4-1.81.61.51.7-1.91.8-1.9-2.01.8-1.81.71.9-2.1-1.6
Delay disc. indifference point, 0s delay0.10.10.70.3-0.8-0.5-0.2-0.10.1-0.2-0.30.1-0.10.20.3-0.0-0.6
Delay disc. indifference point, 16s delay1.61.82.51.4-0.9-1.3-1.51.6-1.51.41.4-1.41.4-1.3-1.31.11.3
Delay disc. indifference point, 2s delay1.21.32.21.1-0.4-0.8-1.11.2-1.11.21.0-1.51.5-1.4-1.50.81.0
Delay disc. indifference point, 24s delay0.10.10.60.6-0.1-0.8-0.50.7-0.2-0.00.3-0.00.0-0.0-0.00.40.2
Delay disc. indifference point, 4s delay0.10.10.50.30.2-0.2-0.30.4-0.30.20.3-0.30.3-0.2-0.50.70.3
Delay disc. indifference point, 8s delay0.20.20.80.0-0.3-0.20.2-0.40.6-0.6-0.60.5-0.50.50.4-0.1-0.9
Indifference point function ln k0.30.60.70.8-0.8-0.6-0.70.8-0.70.80.8-0.80.8-0.7-0.90.80.6
Indifference point function log k0.30.60.70.8-0.8-0.6-0.70.8-0.70.80.8-0.80.8-0.7-0.90.80.6
Patch foraging total patch changes 0 sec0.91.72.8-1.31.71.11.2-1.41.4-1.4-1.61.1-1.11.10.8-1.6-1.2
Patch foraging total patch changes 12 sec1.62.14.4-1.01.20.71.0-1.81.5-1.6-1.91.3-1.31.41.2-2.1-1.9
Patch foraging total patch changes 18 sec1.72.75.1-2.12.12.32.1-1.51.5-1.6-1.21.4-1.41.41.3-1.4-0.7
Patch foraging total patch changes 24 sec0.10.11.00.2-0.0-0.4-0.3-0.20.0-0.1-0.4-0.20.2-0.1-0.2-1.0-0.4
Patch foraging total patch changes 6 sec1.72.65.8-1.01.00.51.0-2.01.7-1.8-2.41.4-1.41.51.3-1.9-2.4
Patch foraging time to switch 0 sec1.02.05.41.8-2.3-1.9-1.61.2-1.21.21.3-0.90.9-0.7-1.02.10.5
Patch foraging water rate 0 sec0.91.95.0-1.82.22.01.6-1.21.1-1.0-1.10.9-0.90.70.9-1.9-0.4
Patch foraging water rate 12 sec0.20.41.8-0.91.41.20.8-0.40.4-0.3-0.20.2-0.20.20.1-0.70.3
Patch foraging water rate 18 sec0.50.71.8-0.91.20.90.7-1.10.9-0.7-1.10.3-0.30.30.5-1.3-0.7
Patch foraging water rate 24 sec0.30.40.8-0.50.00.50.6-0.80.7-0.5-0.90.6-0.60.60.5-0.9-0.7
Patch foraging water rate 6 sec1.11.66.8-1.92.62.31.6-0.70.7-0.5-0.40.3-0.30.10.2-1.40.6
Seeking ratio, delayed vs. immediate footshock0.30.41.5-0.71.20.80.6-0.70.5-0.5-0.8-0.10.10.0-0.1-0.6-0.6
Distance traveled before self-admin0.71.02.4-1.01.20.80.9-1.01.0-1.0-1.00.9-0.91.00.8-1.5-0.7
Distance traveled after self-admin0.10.10.9-0.1-0.0-0.10.1-0.20.2-0.1-0.20.2-0.20.40.3-0.9-0.2
Extensor digitorum longus weight2.610.025.9-4.55.14.84.4-2.22.7-2.9-1.62.6-2.62.62.8-1.2-0.3
Bone: elastic displacement2.93.37.10.9-0.2-0.2-1.12.2-2.02.12.4-2.02.0-2.0-2.01.82.7
Bone: elastic work1.01.44.4-0.10.80.6-0.11.4-1.11.21.6-1.11.1-1.2-1.11.12.1
Bone: endosteal estimation2.04.46.7-2.01.31.72.2-2.22.4-2.4-1.92.6-2.62.52.1-0.5-1.9
Bone: endosteal perimeter2.04.25.9-2.42.22.32.4-2.02.2-2.1-1.82.2-2.22.11.9-1.4-1.3
Epididymis fat weight1.65.48.6-1.1-0.10.31.4-2.22.5-2.6-2.62.9-2.92.92.8-2.1-2.9
Delta time in closed arm before/after self-admin1.00.91.41.0-0.8-0.8-1.10.8-1.11.10.6-1.21.2-1.1-1.10.50.4
Delta time in open arm before/after self-admin0.00.00.1-0.1-0.20.00.20.10.2-0.10.20.3-0.30.00.10.10.1
Diff in mean of infusions in LGA sessions0.30.30.80.8-0.7-0.9-0.70.6-0.60.50.5-0.40.4-0.2-0.40.50.2
Delay discount exponential model param0.60.71.0-1.00.51.01.0-0.90.8-0.7-0.70.9-0.90.80.9-0.7-0.5
Extinction: sum of active levers before priming1.11.22.11.5-1.5-1.4-1.41.0-1.11.00.6-1.11.1-0.9-1.00.80.2
Active lever presses in extinction session 60.30.30.50.5-0.3-0.4-0.50.7-0.60.60.6-0.60.6-0.5-0.60.40.6
Bone: final force1.21.92.6-1.61.41.51.5-1.51.5-1.5-1.21.5-1.51.41.4-0.5-1.0
Bone: final moment0.71.11.4-1.21.01.11.2-1.01.1-1.1-0.81.2-1.21.11.1-0.1-0.6
Food consumed during 24 hour testing period0.91.33.60.1-1.1-0.70.1-1.01.1-1.1-1.41.4-1.41.21.2-0.8-1.9
Glucose0.40.73.31.3-1.8-1.7-1.10.2-0.30.3-0.10.0-0.00.0-0.10.1-0.6
Heart weight0.30.41.4-0.20.70.5-0.10.7-0.60.70.8-0.50.5-0.5-0.50.41.2
Delay discount hyperbolic model param0.70.81.1-1.00.40.91.0-1.00.9-0.8-0.81.0-1.00.91.0-0.8-0.6
Intermittent access intake day 1-15 change1.32.76.31.0-0.2-0.5-1.50.9-1.82.10.8-2.42.4-2.5-2.2-0.41.1
Intermittent access intake escalation1.73.57.81.2-0.3-0.7-1.71.2-2.12.41.1-2.72.7-2.8-2.5-0.11.5
Intermittent access intake escalation 22.73.16.80.60.40.2-1.01.3-1.92.11.4-2.62.6-2.6-2.40.32.1
Intermitt. access day 1 inactive lever presses0.41.31.9-1.00.61.01.2-1.31.4-1.3-1.41.2-1.21.21.1-0.2-1.3
Intermitt. access day 15 inactive lever presses0.61.35.7-1.41.11.50.9-1.50.8-0.5-1.40.1-0.1-0.00.4-2.4-1.0
Intermitt. access escalation Index0.50.83.21.4-1.8-1.8-1.10.7-0.40.30.2-0.10.1-0.00.20.5-0.6
Intermittent access day 1 total infusions0.10.20.70.3-0.6-0.6-0.3-0.00.1-0.1-0.50.2-0.20.00.2-0.8-0.8
Intermittent access day 15 total infusions1.72.54.81.5-0.9-1.2-1.81.2-1.81.90.9-2.02.0-2.2-2.0-0.20.9
Intermittent access terminal intake (last 3 days)0.91.12.70.8-0.3-0.5-1.10.7-1.21.30.4-1.51.5-1.6-1.4-0.60.6
Intermittent access total infusions0.20.30.70.4-0.3-0.2-0.60.2-0.50.6-0.0-0.70.7-0.9-0.6-0.60.1
Intermittent access day 1 locomotion0.70.92.2-0.60.30.30.6-1.01.0-0.9-1.30.9-0.90.80.8-1.5-1.3
Intermittent access day 15 total locomotion1.01.75.7-1.41.41.31.1-1.61.2-1.0-1.70.7-0.70.60.8-2.4-1.3
Intermittent access total locomotion1.31.64.0-1.61.41.61.3-1.51.2-1.0-1.50.7-0.70.50.8-2.0-1.0
Intermittent access standard deviation0.20.31.4-0.80.81.20.7-0.80.4-0.1-0.6-0.10.1-0.3-0.1-0.6-0.2
Left kidney weight0.83.75.6-1.50.31.01.6-2.12.2-2.1-2.22.1-2.12.22.1-1.7-2.4
Right kidney weight1.14.95.9-2.21.81.82.2-2.32.4-2.3-2.42.2-2.22.32.0-2.4-2.1
Cocaine induced anxiety0.20.20.50.5-0.2-0.5-0.60.3-0.50.60.2-0.60.6-0.6-0.7-0.00.2
Post-drug Anxiety0.50.61.40.10.80.2-0.40.7-0.80.80.8-0.90.9-0.8-1.00.11.2
Baseline Anxiety0.20.21.1-0.10.60.40.10.7-0.30.30.7-0.10.1-0.1-0.10.61.0
Tail length0.20.93.8-1.51.91.91.2-0.50.4-0.3-0.10.2-0.20.20.0-0.60.6
Length with tail1.67.012.3-3.42.93.53.2-2.92.7-2.5-2.42.3-2.32.42.1-2.2-1.5
Length without tail2.58.012.1-3.52.53.43.4-3.33.0-2.8-2.92.6-2.62.62.5-1.9-2.1
Times rat made contact with spout0.70.82.70.6-1.4-1.1-0.5-0.80.6-0.6-1.10.7-0.70.50.7-1.0-1.6
Lifetime Intake0.10.20.50.2-0.2-0.1-0.40.0-0.40.5-0.2-0.60.6-0.7-0.5-0.7-0.1
Liver weight, left1.01.65.6-1.20.71.11.1-1.61.2-1.0-1.70.9-0.90.71.0-2.4-1.5
Liver weight, right1.01.83.1-1.71.11.81.6-1.61.4-1.1-1.41.0-1.01.01.0-1.4-1.0
Locomotor activity2.13.37.6-2.52.72.82.3-1.81.6-1.4-1.51.0-1.00.91.3-2.3-0.6
Locomotor testing distance1.01.83.5-1.71.81.91.7-1.51.2-1.0-1.40.6-0.60.61.1-1.9-0.8
Locomotor testing rearing0.81.52.5-1.11.11.01.3-1.41.3-1.2-1.51.0-1.01.21.2-1.6-1.3
Locomotion in novel chamber0.60.82.9-1.41.31.71.1-1.20.6-0.5-0.70.1-0.10.10.1-0.7-0.1
Locomotion in novel chamber post-restriction0.00.00.20.2-0.4-0.2-0.10.2-0.00.10.00.2-0.20.20.20.10.0
Fecal boli incidents, locomotor time 10.40.62.90.9-0.6-0.9-0.71.0-0.50.40.90.0-0.00.0-0.11.70.8
Change in fecal boli incidents, locomotor task0.30.30.9-0.31.00.40.00.0-0.20.1-0.1-0.70.7-0.8-0.6-0.50.1
Time >=10cm from walls, locomotor time 12.32.43.4-1.81.51.71.8-1.71.7-1.6-1.71.3-1.31.21.4-1.5-1.3
Bouts of movement, locomotor time 11.01.12.51.0-0.8-0.9-1.01.6-1.21.01.6-0.50.5-0.6-0.61.21.4
Total resting periods, locomotor time 11.41.62.91.1-0.9-1.0-1.21.6-1.41.31.7-0.80.8-1.0-1.11.41.6
Rest time, locomotor task time 11.72.14.51.9-2.1-2.0-1.91.3-1.41.41.2-0.90.9-1.0-1.11.30.8
Distance moved, locomotor task time 10.30.41.6-0.71.31.10.60.4-0.10.20.6-0.40.4-0.2-0.30.10.9
Vertical activity count, locomotor time 10.20.41.2-0.91.11.00.9-0.30.5-0.5-0.30.4-0.40.60.5-0.6-0.0
Time >=10cm from walls, locomotor time 21.62.43.6-1.30.50.91.5-1.61.9-1.9-1.61.9-1.91.81.8-0.5-1.7
Bouts of movement, locomotor time 20.50.81.91.1-1.4-1.3-1.01.3-0.70.51.00.1-0.10.30.11.20.6
Total resting periods, locomotor time 20.50.92.41.2-1.5-1.4-1.01.2-0.70.50.90.2-0.20.30.11.20.5
Rest time, locomotor task time 21.01.23.31.6-1.3-1.8-1.70.9-1.11.00.7-0.80.8-0.7-0.90.60.4
Distance moved, locomotor task time 20.50.62.5-1.11.41.61.10.20.2-0.20.6-0.00.0-0.1-0.20.81.0
Vertical activity count, locomotor time 21.21.72.9-1.61.21.61.7-0.91.3-1.3-0.61.6-1.61.61.5-0.1-0.5
Light reinforcement 10.00.10.30.4-0.6-0.6-0.3-0.00.1-0.1-0.30.1-0.10.00.5-0.1-0.5
Light reinforcement 20.20.31.20.8-1.0-1.1-0.60.0-0.1-0.0-0.40.3-0.30.30.6-0.5-0.8
Bone: marrow area2.14.56.8-2.01.31.72.3-2.22.4-2.4-2.02.6-2.62.52.1-0.5-1.9
Bone: maximum diameter2.64.86.6-2.52.62.42.5-2.22.3-2.4-2.02.1-2.12.02.0-1.5-1.6
Bone: maximum force2.03.65.4-2.32.22.32.3-1.72.0-2.1-1.42.0-2.01.81.9-0.7-1.0
Bone: maximum moment1.32.43.8-1.91.81.91.9-1.31.6-1.7-0.91.7-1.71.61.6-0.2-0.6
Mean time between licks in bursts0.30.72.10.10.20.4-0.11.0-0.90.91.3-0.70.7-0.7-0.80.71.4
Mean num. licks in bursts0.20.20.70.7-0.7-0.8-0.50.5-0.20.20.4-0.10.1-0.1-0.50.80.1
Cd content in liver2.73.05.51.2-0.7-0.7-1.32.1-1.91.92.3-1.81.8-1.8-1.71.82.3
Co content in liver0.60.72.0-0.21.10.50.11.0-0.60.41.2-0.50.5-0.5-0.71.41.4
Cu content in liver0.80.96.21.3-2.5-1.5-1.20.0-0.50.5-0.0-0.30.3-0.4-0.40.2-0.7
Fe content in liver1.11.43.4-0.5-0.50.10.7-1.51.3-1.3-1.51.2-1.21.31.3-0.8-1.8
K content in liver3.93.710.2-0.7-0.4-0.11.1-2.42.2-2.3-2.72.0-2.01.81.9-1.3-3.2
Mg content in liver0.70.82.80.1-0.3-0.60.2-1.01.0-1.2-1.30.8-0.80.70.7-0.4-1.7
Mn content in liver0.60.61.9-0.5-0.20.30.5-1.20.8-0.6-1.30.2-0.20.20.6-1.4-1.3
Na content in liver1.92.06.70.3-1.5-1.00.2-1.61.4-1.4-1.91.4-1.41.31.3-0.9-2.6
Rb content in liver0.30.31.10.6-0.8-1.0-0.5-0.50.2-0.3-0.60.2-0.20.20.0-0.4-1.0
Se content in liver0.20.20.9-0.0-0.4-0.10.2-0.50.4-0.3-0.60.2-0.20.20.3-1.0-0.7
Sr content in liver0.80.71.4-1.11.21.21.1-0.70.8-0.8-0.60.6-0.60.60.6-0.3-0.3
Zn content in liver3.13.55.6-1.20.30.61.4-2.12.0-2.1-2.32.2-2.22.12.1-1.5-2.4
Bone: minimum diameter4.58.212.2-3.53.03.43.5-2.73.1-2.9-2.32.9-2.92.82.9-1.6-1.7
Time in familiar zone, hab. session 10.50.42.20.5-0.2-0.5-0.11.0-0.30.11.00.4-0.40.50.31.50.8
Time in novel zone, hab. session 10.30.31.10.1-0.6-0.3-0.3-0.80.2-0.0-0.8-0.30.3-0.3-0.1-1.0-0.9
Total zone transitions, hab. session 10.40.62.6-0.91.61.40.80.2-0.10.20.7-0.40.4-0.3-0.30.81.2
Total locomotion distance, hab. session 11.21.73.3-1.71.31.71.8-1.21.3-1.2-0.91.3-1.31.41.3-0.7-0.5
Locomotion velocity, hab. session 11.01.43.4-1.71.61.91.7-1.01.1-1.0-0.70.9-0.91.00.9-0.6-0.3
Time in familiar zone, hab. session 20.60.71.40.8-0.3-0.7-0.81.2-1.00.81.1-0.60.6-0.6-0.41.01.0
Time in novel zone, hab. session 20.90.91.4-1.20.91.21.1-1.21.1-0.8-1.10.7-0.70.70.5-1.1-0.7
Total zone transitions, hab. session 20.10.10.3-0.20.50.20.4-0.40.4-0.6-0.30.3-0.30.40.3-0.1-0.3
Total locomotion distance, hab. session 20.30.40.6-0.40.20.30.6-0.70.6-0.8-0.60.6-0.60.80.5-0.7-0.8
Locomotion velocity, hab. session 20.20.20.5-0.1-0.10.00.4-0.60.5-0.6-0.50.5-0.50.60.4-0.5-0.7
Novel to familiar place preference ratio0.10.10.60.1-0.50.0-0.1-0.1-0.10.3-0.1-0.40.4-0.4-0.2-0.80.0
Novelty place preference0.20.30.50.2-0.5-0.0-0.30.2-0.40.70.2-0.70.7-0.7-0.5-0.70.4
Time in novel zone, NPP test0.20.30.60.2-0.30.1-0.20.3-0.50.70.3-0.80.8-0.8-0.5-0.60.5
Total zone transitions, NPP test1.52.15.5-2.02.32.11.9-1.31.4-1.4-0.91.1-1.11.31.1-0.6-0.4
Total locomotion distance, NPP test1.72.43.9-1.91.81.92.0-1.51.6-1.6-1.21.4-1.41.51.3-1.0-0.9
Locomotion velocity, NPP test1.72.44.0-1.91.81.92.0-1.61.6-1.6-1.31.4-1.41.51.3-1.0-1.0
Intraocular pressure0.30.51.9-0.81.41.00.8-0.10.5-0.5-0.10.7-0.70.60.60.30.3
Delta distance traveled before/after self-admin0.10.10.10.3-0.4-0.4-0.20.3-0.20.20.30.0-0.0-0.0-0.00.30.2
Delta ambulatory time before/after self-admin0.00.00.00.1-0.1-0.2-0.00.0-0.00.00.10.1-0.10.10.10.10.1
Parametrial fat weight5.813.718.2-3.21.52.63.5-4.14.0-3.8-4.14.0-4.04.14.3-3.7-3.8
Pavlov. Cond. lever latency0.60.81.40.7-0.7-0.5-0.70.9-1.11.20.9-0.90.9-1.0-0.90.11.0
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.2-0.4-0.40.2-0.10.00.2-0.10.1-0.1-0.00.30.1
Pavlov. Cond. change in total contacts0.30.30.60.7-0.6-0.7-0.80.4-0.50.50.4-0.50.5-0.4-0.70.40.2
Pavlov. Cond. index score0.10.10.3-0.20.50.20.1-0.30.3-0.4-0.20.2-0.20.20.10.2-0.2
Pavlov. Cond. latency score0.10.20.5-0.40.60.30.3-0.50.5-0.7-0.40.4-0.40.40.40.0-0.5
Pavlov. Cond. lever contacts0.50.61.3-0.50.40.20.5-0.91.0-1.1-0.91.0-1.01.00.80.0-1.0
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.10.10.20.00.00.00.00.1-0.10.10.10.20.0
Pavlov. Cond. intertrial magazine entries1.72.13.5-0.90.20.51.2-1.71.7-1.5-1.81.6-1.61.51.5-1.4-1.9
Pavlov. Cond. lever-magazine prob. diff.0.10.20.4-0.30.40.10.2-0.60.5-0.6-0.60.3-0.30.30.3-0.2-0.6
Pavlov. Cond. response bias0.00.00.00.00.1-0.1-0.1-0.10.1-0.1-0.1-0.00.0-0.0-0.0-0.1-0.1
Pavlov. Cond. lever latency0.10.10.3-0.1-0.4-0.00.2-0.10.3-0.3-0.10.4-0.40.60.50.5-0.3
Pavlov. Cond. magazine entry latency0.10.10.2-0.00.50.1-0.00.1-0.10.00.1-0.40.4-0.5-0.20.10.1
Pavlov. Cond. change in total contacts0.30.52.6-0.91.61.30.6-0.0-0.10.20.3-0.30.3-0.5-0.4-0.30.8
Pavlov. Cond. index score0.10.10.5-0.20.70.20.1-0.20.0-0.2-0.2-0.20.2-0.4-0.2-0.2-0.0
Pavlov. Cond. latency score0.10.10.5-0.10.70.20.0-0.1-0.1-0.1-0.0-0.40.4-0.5-0.3-0.00.1
Pavlov. Cond. lever contacts0.10.10.40.40.1-0.3-0.40.2-0.40.40.2-0.50.5-0.6-0.5-0.30.3
Pavlov. Cond. magazine entry number0.30.31.50.8-1.2-0.8-0.70.5-0.50.60.5-0.20.2-0.2-0.20.30.2
Pavlov. Cond. intertrial magazine entries1.01.63.1-0.6-0.20.20.8-1.51.3-1.3-1.61.4-1.41.61.4-1.0-1.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.30.80.30.3-0.40.3-0.4-0.40.1-0.1-0.10.1-0.3-0.3
Pavlov. Cond. response bias0.10.10.6-0.30.80.40.2-0.1-0.10.1-0.1-0.30.3-0.4-0.3-0.60.2
Time in closed arm before self-admin0.70.91.6-0.80.60.61.0-1.01.1-1.2-0.81.1-1.11.31.0-0.7-0.8
Time in closed arm after self-admin0.50.61.11.0-1.0-1.0-0.90.7-0.80.70.6-0.70.7-0.5-0.60.70.3
Time in open arm before self-admin0.10.10.5-0.10.50.30.00.2-0.10.10.2-0.30.3-0.1-0.30.70.4
Time in open arm after self-admin0.10.10.2-0.30.20.20.3-0.40.4-0.3-0.50.3-0.30.10.2-0.2-0.5
Bone: periosteal estimation2.24.77.0-2.62.52.62.6-2.02.3-2.3-1.72.3-2.32.12.0-0.8-1.2
Bone: periosteal perimeter2.64.47.2-2.52.72.52.5-1.82.2-2.2-1.62.2-2.22.12.0-1.2-1.1
Bone: post-yield work2.94.26.9-1.50.61.01.8-2.22.5-2.5-2.02.6-2.62.62.4-0.5-2.3
Progressive ratio test 1 active lever presses0.40.43.0-0.20.10.20.0-0.80.3-0.1-1.1-0.10.1-0.3-0.1-1.7-1.0
Progressive ratio test 1 breakpoint0.40.52.9-0.30.20.20.1-0.90.3-0.1-1.1-0.10.1-0.3-0.1-1.7-1.0
Progressive ratio test 1 inactive lever presses0.20.21.5-0.20.10.2-0.1-0.40.10.1-0.7-0.30.3-0.4-0.4-1.2-0.7
Progressive ratio test 2 active lever presses0.70.94.5-1.01.21.10.6-1.10.4-0.2-1.2-0.30.3-0.4-0.3-2.1-0.6
Progressive ratio test 2 breakpoint0.70.84.2-1.01.21.10.6-1.00.3-0.1-1.1-0.30.3-0.5-0.4-2.0-0.5
Progressive ratio test 2 inactive lever presses0.20.42.4-0.70.81.00.3-0.4-0.00.2-0.5-0.40.4-0.5-0.4-1.50.0
Incentive Sensitization - Responses0.50.72.5-1.11.61.30.7-0.60.2-0.0-0.6-0.30.3-0.4-0.4-1.60.2
Incentive Sensitization - Breakpoint0.40.52.0-0.91.41.10.5-0.60.10.0-0.5-0.30.3-0.4-0.4-1.40.2
Sum of active levers in priming session hrs 5-60.40.40.8-0.80.90.90.8-0.40.6-0.6-0.30.5-0.50.60.5-0.3-0.1
Progressive ratio1.52.43.81.0-0.9-0.5-1.31.7-1.81.91.8-1.81.8-2.0-1.81.01.7
Food seeking constrained by brief footshock0.10.10.4-0.10.1-0.10.1-0.30.5-0.7-0.30.4-0.40.40.40.2-0.5
Seeking ratio, punishment vs. effort1.31.83.3-0.60.60.00.8-1.51.7-1.7-1.71.5-1.51.61.5-0.9-1.8
Retroperitoneal fat weight1.25.27.1-2.41.82.12.4-2.52.4-2.1-2.42.3-2.32.32.3-2.7-1.9
Reaction time number correct1.22.33.2-1.3-0.01.01.3-1.81.6-1.4-1.81.6-1.61.41.8-1.6-1.7
Reaction time mean minus median1.02.44.1-1.10.70.71.4-1.61.8-1.9-1.61.9-1.92.02.0-0.2-1.6
Reaction time mean minus median AUC0.10.30.9-0.2-0.00.00.3-0.40.7-0.7-0.40.8-0.80.90.90.3-0.6
Reaction time num false alarms0.50.71.5-0.50.20.40.8-0.71.0-1.1-0.61.2-1.21.11.10.0-0.7
Reaction time num false alarms AUC0.40.71.7-0.40.10.30.7-0.50.9-1.1-0.41.3-1.31.21.20.3-0.5
Reaction time trials correct on left1.22.33.2-1.3-0.01.01.3-1.81.6-1.4-1.81.6-1.61.41.8-1.6-1.7
Reaction time trials on left1.42.63.7-1.40.01.11.4-1.91.8-1.5-1.91.8-1.81.61.9-1.7-1.9
Reaction time mean1.32.13.4-1.30.81.01.5-1.51.6-1.7-1.41.7-1.71.81.9-0.5-1.2
Reaction time mean AUC1.32.03.2-1.20.91.01.5-1.51.6-1.6-1.51.6-1.61.71.8-0.7-1.3
Median of all reaction times0.71.01.7-0.90.60.81.2-1.01.1-1.2-0.91.2-1.21.21.3-0.5-0.7
Reaction time omissions0.50.71.8-0.4-0.30.10.6-0.91.0-0.9-0.91.0-1.00.91.4-0.0-1.1
Reaction time false alarm rate0.20.21.20.10.60.10.10.6-0.2-0.10.80.1-0.10.1-0.11.10.9
Reaction time premature initiation rate0.10.20.8-0.30.90.40.4-0.10.1-0.2-0.00.1-0.10.20.3-0.80.2
Reaction time premature initiations0.30.61.5-0.70.50.50.7-0.70.7-0.7-0.70.8-0.80.81.0-1.2-0.6
Std. dev. reaction times2.03.76.1-1.50.91.11.8-2.02.2-2.3-2.02.3-2.32.42.5-0.7-1.9
Reaction time trials completed1.42.63.7-1.40.01.11.4-1.91.8-1.5-1.91.8-1.81.61.9-1.7-1.9
Reaction time trials AUC1.22.33.2-1.40.11.21.4-1.81.7-1.4-1.81.6-1.61.51.8-1.6-1.7
Run reversals in cocaine runway, females1.01.01.91.3-1.1-1.4-1.41.0-1.01.00.8-0.80.8-0.8-0.71.00.5
Run reversals in cocaine runway, males0.60.61.3-0.50.20.30.5-0.80.7-0.8-0.71.1-1.11.10.7-0.6-0.8
Latency to leave start box in cocaine runway7.07.912.33.5-3.3-3.4-3.33.0-2.92.92.6-2.32.3-2.2-2.52.81.8
Latency to leave start box in cocaine runway, F6.97.813.53.7-3.5-3.7-3.52.7-2.82.72.2-2.42.4-2.2-2.52.61.3
Latency to leave start box in cocaine runway, M1.61.52.61.0-0.6-0.6-0.91.6-1.41.41.5-1.01.0-1.1-1.11.61.6
Std. dev. time between licks in bursts0.30.40.80.6-0.2-0.4-0.60.7-0.80.90.7-0.80.8-0.8-0.8-0.10.7
Total sessions with >9 infusions0.50.63.0-0.50.40.40.2-1.00.4-0.2-1.2-0.20.2-0.3-0.1-1.7-1.2
Short access day 1 total inactive lever presses0.70.91.7-1.01.00.80.8-1.00.9-1.0-1.10.7-0.70.70.7-1.3-0.9
Short access day 10 total inactive lever presses0.71.73.1-1.00.70.71.2-1.21.5-1.6-1.11.7-1.71.81.7-0.3-1.1
Short access day 1 total infusions0.70.92.1-0.80.60.50.7-1.20.9-0.9-1.40.8-0.80.80.8-1.5-1.3
Short access day 10 total infusions0.00.00.1-0.1-0.10.10.1-0.10.2-0.3-0.20.3-0.30.20.3-0.1-0.3
Short access total infusions0.00.00.20.1-0.2-0.1-0.2-0.1-0.10.1-0.2-0.20.2-0.3-0.1-0.4-0.3
Short access day 1 locomotion2.02.55.1-1.61.41.31.4-1.91.6-1.5-2.01.2-1.21.11.3-2.3-1.8
Short access day 10 total locomotion1.01.94.2-0.90.50.51.0-1.61.6-1.6-1.91.4-1.41.31.3-1.4-2.1
Short access total locomotion1.72.15.3-1.51.41.31.2-1.91.4-1.2-2.10.8-0.80.70.8-2.3-1.7
One hour access (0.3 mA shock)0.50.52.0-0.91.31.20.5-0.2-0.00.2-0.1-0.40.4-0.5-0.3-1.40.5
Compulsive drug intake0.60.71.20.9-0.8-0.9-0.91.0-0.90.91.1-0.80.8-0.7-0.70.60.8
One hour access (shock baseline)0.30.52.3-0.71.21.00.6-0.60.3-0.1-0.8-0.10.1-0.3-0.1-1.5-0.2
Social response proportion0.60.73.8-1.22.01.61.10.10.3-0.30.2-0.00.00.10.1-0.40.9
Social responses1.11.47.4-1.72.72.21.5-0.00.3-0.30.30.2-0.20.20.3-0.51.2
Social time0.20.21.2-0.11.10.40.30.6-0.2-0.10.70.0-0.00.10.00.30.9
Soleus weight2.05.88.9-3.02.82.92.9-2.22.6-2.6-1.92.4-2.42.42.3-1.0-1.4
Bone: stiffness1.11.92.5-1.41.11.31.5-1.41.5-1.5-1.31.4-1.41.41.6-1.0-1.2
Tibialis anterior weight1.75.823.1-3.74.84.33.4-1.21.6-1.7-0.51.3-1.31.21.5-0.20.8
Time to tail flick, vehicle, before self-admin0.80.82.11.0-0.9-1.0-0.91.1-0.90.70.9-0.70.7-0.6-0.71.40.6
Time to tail flick, vehicle, after self-admin1.92.54.8-0.7-0.10.11.0-1.71.8-1.8-1.91.9-1.91.91.8-1.4-2.2
Time to tail flick, test, before self-admin0.10.10.4-0.1-0.1-0.00.3-0.20.4-0.5-0.20.6-0.60.50.50.3-0.3
Time to tail flick, test, after self-admin0.40.40.90.7-0.2-0.6-0.60.9-0.80.70.7-0.40.4-0.6-0.60.50.8
Delta time to tail flick, vehicle, before/after SA1.51.41.8-1.00.70.71.1-1.31.3-1.3-1.21.4-1.41.31.3-1.3-1.1
Delta time to tail flick, test, before/after SA0.20.20.8-0.50.90.60.4-0.20.0-0.0-0.20.1-0.10.10.1-0.80.2
Tibia length3.39.012.9-3.62.73.43.5-3.13.2-3.1-2.73.1-3.13.03.1-1.8-2.0
Ambulatory time before self-admin0.40.61.3-0.70.60.50.7-0.70.8-0.8-0.70.9-0.90.90.8-1.1-0.6
Ambulatory time after self-admin0.30.31.3-0.30.20.10.4-0.60.6-0.5-0.60.6-0.60.70.6-1.1-0.6
Bone: tissue strength0.20.20.80.6-0.9-0.6-0.60.4-0.40.40.5-0.30.3-0.3-0.30.60.3
Total heroin consumption1.31.64.1-0.3-0.5-0.20.6-1.31.3-1.3-1.71.3-1.31.51.4-1.0-2.0
Bone: trabecular number1.21.95.00.30.80.3-0.51.6-1.41.41.8-1.41.4-1.5-1.71.32.2
Bone: trabecular spacing0.30.31.40.7-1.2-1.0-0.6-0.00.0-0.1-0.10.4-0.40.50.40.4-0.5
Bone: trabecular thickness0.50.61.4-0.20.70.6-0.10.8-0.70.70.9-0.90.9-1.0-0.90.41.2
Bone: trabecular tissue density0.81.25.61.4-2.4-1.7-1.40.0-0.60.8-0.3-0.60.6-0.6-0.2-0.9-0.8
Water consumed over 24 hours2.12.87.0-0.7-0.1-0.00.7-2.11.8-1.9-2.31.8-1.81.61.6-1.7-2.6
Number of responses in last shaping day0.50.52.4-0.0-0.7-0.00.3-1.10.6-0.6-1.30.4-0.40.40.4-0.0-1.6