Hub : Genes

Ext1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Ext1 0.44 0.12 0.0e+00 0.35 0.43 0.44 0.45 2.1e-39 1.2e-51 1.2e-53 2.8e-54
2 OFC mRNA stability Ext1 0.43 0.17 7.5e-06 0.13 0.2 0.14 0.18 4.8e-04 1.3e-05 4.1e-04 3.6e-05
3 Brain mRNA stability Ext1 0.05 0.04 1.4e-04 0.04 0.05 0.04 0.04 1.4e-04 2.5e-05 8.1e-05 8.9e-05
4 Brain gene expression Ext1 0.06 0.04 6.8e-05 0.05 0.05 0.05 0.03 1.9e-05 1.9e-05 3.0e-05 5.5e-04
5 NAcc gene expression Ext1 0.05 0.04 4.3e-04 0.03 0.02 0.03 0.02 2.7e-04 1.7e-03 6.1e-04 2.3e-03
6 BLA mRNA stability Ext1 0.34 0.12 0.0e+00 0.27 0.26 0.27 0.28 7.8e-15 4.0e-14 1.7e-14 2.1e-15
7 Liver gene expression Ext1 0.07 0.05 2.3e-08 0.06 0.06 0.07 0.07 7.9e-07 1.8e-07 5.5e-08 7.0e-08
8 IL mRNA stability Ext1 0.2 0.12 3.1e-03 0.07 0.03 0.03 0.01 1.1e-02 6.5e-02 7.1e-02 1.5e-01
9 PL gene expression Ext1 0.02 0.02 5.1e-03 0.01 0 0 0 1.9e-02 8.8e-02 2.7e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.62.00.01.2-0.30.3-0.6-0.6-0.70.8-1.4
Area under the delay curve0.60.61.0-1.0-0.7-0.90.9-0.7-0.7-0.90.8-0.4
BMI with tail4.113.221.14.44.64.1-3.93.63.53.4-3.01.1
BMI without tail4.18.512.93.53.63.3-3.22.92.82.8-2.21.0
Body weight5.221.729.55.44.85.2-5.14.74.84.7-4.22.2
Weight adjusted by age1.21.43.31.51.81.2-1.21.11.01.0-0.8-0.3
Bone surface0.10.10.60.30.80.2-0.10.1-0.1-0.10.1-0.5
Bone volume0.40.62.0-0.30.8-0.50.5-0.8-0.8-0.90.8-1.4
Breakpoint value in progressive ratio session0.40.41.8-0.1-1.10.2-0.20.40.40.5-0.51.3
Number of licking bursts0.20.20.40.2-0.00.4-0.30.50.40.5-0.50.6
Context. condit. distance diff. score1.51.82.41.51.31.5-1.51.31.21.3-1.40.6
Locomotion velocity, session 10.20.20.50.50.00.5-0.30.70.40.6-0.20.5
Locomotion distance, session 10.10.10.20.30.20.3-0.30.50.20.4-0.10.3
Locomotion velocity, session 24.14.86.8-2.1-1.2-2.42.4-2.1-2.4-2.32.6-1.7
Locomotion distance, session 20.50.81.5-0.8-0.1-0.90.8-0.9-0.9-0.91.2-0.9
Locomotion velocity, session 32.83.34.52.11.62.0-1.92.11.72.0-1.21.4
Locomotion distance, session 32.22.43.01.71.11.7-1.71.71.61.7-1.01.3
Stereotopy head waving bouts, day 30.40.50.70.80.50.8-0.70.80.70.8-0.80.5
Stereotopy head waving duration, day 30.20.21.10.20.8-0.10.2-0.4-0.3-0.40.0-1.0
Locomotion velocity, session 70.30.31.50.71.20.5-0.50.10.30.1-0.1-0.5
Locomotion distance, session 71.51.93.41.61.81.5-1.71.01.41.1-1.30.1
Stereotopy head waving bouts, day 74.34.88.1-1.70.2-2.02.2-2.4-2.5-2.42.4-2.8
Stereotopy head waving duration, day 72.73.34.5-1.6-0.2-1.81.9-1.9-2.1-2.02.0-2.1
Locomotion velocity, session 80.10.10.10.30.30.4-0.30.30.30.3-0.30.1
Locomotion distance, session 80.81.22.31.31.51.2-1.31.01.01.0-0.80.3
Degree of sensitization distance0.10.10.3-0.00.40.0-0.0-0.2-0.0-0.3-0.3-0.5
Degree of sensitization stereotypy6.06.58.3-2.4-0.6-2.62.7-2.8-2.9-2.82.9-2.7
Conditioned locomotion0.40.40.80.70.10.7-0.70.60.60.7-0.90.6
Cocaine response after cond. corrected0.50.61.0-0.9-1.0-0.90.8-0.8-0.7-0.60.6-0.1
Cocaine response after cond. not corrected0.80.91.4-1.1-0.7-1.00.9-1.2-1.0-1.00.8-0.7
Cocaine response before conditioning0.20.21.00.00.8-0.10.0-0.5-0.2-0.40.1-1.0
Saline control response0.70.91.60.70.10.9-1.11.01.31.0-1.11.0
Bone: connectivity density0.10.10.4-0.10.3-0.20.2-0.1-0.3-0.30.6-0.4
Bone: cortical apparent density0.91.21.6-1.2-0.8-1.21.3-1.0-1.3-1.11.1-0.9
Bone: cortical area1.72.57.42.02.71.7-1.71.01.21.0-1.1-0.5
Bone: cortical porosity0.30.31.70.71.30.4-0.5-0.10.1-0.0-0.1-0.8
Bone: cortical porosity0.50.52.40.91.60.7-0.70.20.30.2-0.2-0.6
Bone: cortical thickness0.30.62.70.81.60.5-0.5-0.00.0-0.0-0.1-1.1
Bone: cortical thickness0.50.52.30.41.50.1-0.2-0.4-0.3-0.40.3-1.3
Bone: cortical tissue density1.01.31.7-1.3-0.9-1.21.3-1.0-1.3-1.11.1-0.8
Condit. Reinf. active minus inactive responses0.20.21.0-0.1-0.50.1-0.10.60.30.40.21.0
Condit. Reinf. active-inactive response ratio1.61.82.7-1.6-1.5-1.51.5-0.9-1.3-1.11.6-0.3
Condit. Reinf. active responses1.41.73.11.10.41.3-1.31.81.41.6-0.81.7
Condit. Reinf. inactive responses4.35.16.22.41.62.5-2.52.42.42.5-2.01.8
Incentive salience index mean0.60.81.80.60.00.8-0.81.30.91.1-0.21.4
Condit. Reinf. lever presses0.50.71.30.90.60.9-0.81.10.80.9-0.20.8
Condit. Reinf. active minus inactive responses1.61.92.91.71.71.6-1.41.41.31.3-1.00.6
Condit. Reinf. active-inactive response ratio2.12.23.41.81.81.7-1.61.51.41.3-1.10.5
Condit. Reinf. active responses2.73.86.32.42.52.3-2.01.81.81.8-1.50.7
Condit. Reinf. inactive responses0.30.41.00.81.00.7-0.70.40.50.5-0.50.0
Condit. Reinf. lever presses0.30.41.20.01.1-0.20.3-0.5-0.6-0.60.8-1.1
Condit. Reinf. lever reinforcers received2.23.16.02.22.42.1-1.81.61.61.6-1.30.4
Conditioned reinforcement - actives0.00.00.20.20.40.2-0.10.20.00.10.1-0.1
Conditioned reinforcement - inactives0.40.51.20.91.10.8-0.60.90.50.7-0.20.0
Conditioned locomotion2.02.53.91.50.91.7-1.62.01.71.7-1.31.5
Patch foraging indifference point 0 sec1.52.43.41.61.01.6-1.71.91.81.6-1.11.5
Patch foraging indifference point AUC1.71.92.41.41.01.5-1.51.51.51.4-1.31.2
Delay disc. indifference point, 0s delay0.10.10.4-0.0-0.60.1-0.10.20.20.1-0.50.4
Delay disc. indifference point, 16s delay2.22.22.9-1.7-1.0-1.61.6-1.6-1.6-1.71.3-1.3
Delay disc. indifference point, 2s delay0.91.01.8-1.0-0.7-1.11.1-0.8-1.0-1.11.3-0.7
Delay disc. indifference point, 24s delay0.10.10.2-0.5-0.4-0.30.1-0.3-0.1-0.4-0.3-0.2
Delay disc. indifference point, 4s delay0.10.10.2-0.30.0-0.30.3-0.5-0.3-0.40.4-0.4
Delay disc. indifference point, 8s delay0.20.20.70.1-0.50.3-0.30.50.60.4-0.50.8
Indifference point function ln k0.50.60.9-0.9-0.9-0.90.9-0.8-0.8-0.70.8-0.4
Indifference point function log k0.50.60.9-0.9-0.9-0.90.9-0.8-0.8-0.70.8-0.4
Patch foraging total patch changes 0 sec1.01.62.31.20.81.3-1.41.51.51.3-1.01.2
Patch foraging total patch changes 12 sec1.72.23.61.20.31.4-1.61.91.61.6-1.41.9
Patch foraging total patch changes 18 sec2.53.25.32.22.32.0-2.01.61.81.5-1.60.4
Patch foraging total patch changes 24 sec0.10.10.5-0.2-0.50.0-0.10.40.20.1-0.10.7
Patch foraging total patch changes 6 sec2.13.06.71.30.21.6-1.82.21.91.9-1.32.6
Patch foraging time to switch 0 sec1.42.14.3-1.7-2.1-1.61.5-1.7-1.3-1.30.8-0.4
Patch foraging water rate 0 sec1.32.14.21.72.11.6-1.51.61.31.3-0.80.1
Patch foraging water rate 12 sec0.20.31.50.61.20.4-0.40.30.20.20.2-0.5
Patch foraging water rate 18 sec0.60.81.50.90.50.9-0.91.20.91.0-0.60.7
Patch foraging water rate 24 sec0.30.40.70.60.00.6-0.60.80.70.8-0.40.5
Patch foraging water rate 6 sec0.91.35.61.52.41.1-1.00.70.60.6-0.2-1.0
Seeking ratio, delayed vs. immediate footshock0.20.20.50.50.20.4-0.40.70.40.60.30.7
Distance traveled before self-admin1.51.62.11.51.21.4-1.41.41.41.3-1.00.7
Distance traveled after self-admin0.00.00.10.0-0.10.1-0.10.10.30.1-0.30.3
Extensor digitorum longus weight2.811.029.44.25.43.7-3.72.32.72.3-2.4-0.4
Bone: elastic displacement3.23.67.4-1.20.5-1.71.7-2.2-2.0-2.22.1-2.7
Bone: elastic work1.51.96.2-0.21.4-0.70.8-1.5-1.3-1.41.2-2.5
Bone: endosteal estimation1.83.95.12.11.42.1-2.31.92.22.0-2.11.4
Bone: endosteal perimeter1.83.75.32.32.02.2-2.21.82.01.8-1.90.8
Epididymis fat weight1.94.412.10.8-1.81.4-1.62.02.42.2-2.33.5
Delta time in closed arm before/after self-admin1.31.32.1-1.1-0.6-1.21.2-1.1-1.2-1.21.4-0.7
Delta time in open arm before/after self-admin0.30.30.50.5-0.20.5-0.50.50.60.7-0.70.6
Diff in mean of infusions in LGA sessions0.10.10.2-0.4-0.4-0.40.3-0.3-0.4-0.30.4-0.0
Delay discount exponential model param0.80.81.31.10.91.0-1.00.80.91.0-0.90.4
Extinction: sum of active levers before priming0.30.31.1-0.5-1.0-0.50.4-0.2-0.4-0.10.50.6
Active lever presses in extinction session 60.00.00.1-0.2-0.3-0.10.2-0.2-0.1-0.1-0.10.1
Bone: final force1.42.23.11.81.61.7-1.71.41.41.4-1.50.7
Bone: final moment0.81.32.01.41.41.3-1.31.01.01.0-1.10.2
Food consumed during 24 hour testing period1.31.53.90.4-1.00.8-0.91.41.31.2-1.52.0
Glucose1.11.74.1-1.7-2.0-1.51.4-0.9-1.0-1.01.10.2
Heart weight0.81.12.2-0.70.5-0.91.0-1.1-1.2-1.01.3-1.5
Delay discount hyperbolic model param0.70.71.01.00.81.0-0.90.80.81.0-0.90.5
Intermittent access intake day 1-15 change0.90.92.5-0.8-0.1-0.91.1-0.5-1.2-1.01.6-0.6
Intermittent access intake escalation0.80.82.1-0.9-0.3-0.91.1-0.5-1.1-0.91.5-0.3
Intermittent access intake escalation 20.80.71.9-0.30.6-0.60.8-0.5-0.9-0.91.4-1.2
Intermitt. access day 1 inactive lever presses0.50.50.90.60.00.7-0.80.90.80.8-0.60.9
Intermitt. access day 15 inactive lever presses1.21.33.00.90.21.1-0.91.71.01.4-0.41.7
Intermitt. access escalation Index0.90.84.0-0.9-2.0-0.50.3-0.3-0.1-0.1-0.41.3
Intermittent access day 1 total infusions0.40.51.0-0.9-1.0-0.70.7-0.7-0.5-0.50.50.2
Intermittent access day 15 total infusions1.21.31.9-1.4-1.2-1.21.3-0.9-1.2-1.01.40.1
Intermittent access terminal intake (last 3 days)0.40.41.0-0.7-0.3-0.70.8-0.5-0.8-0.71.0-0.3
Intermittent access total infusions0.60.71.1-0.9-0.4-0.81.0-0.8-0.9-0.81.1-0.6
Intermittent access day 1 locomotion0.10.10.3-0.2-0.4-0.00.10.10.10.10.20.6
Intermittent access day 15 total locomotion0.80.91.60.80.51.0-0.81.21.01.1-0.61.2
Intermittent access total locomotion0.50.61.10.91.10.9-0.60.90.70.7-0.40.2
Intermittent access standard deviation0.30.31.20.10.7-0.10.40.1-0.4-0.31.1-0.7
Left kidney weight0.30.81.10.80.10.9-0.90.91.11.0-1.11.0
Right kidney weight0.51.42.01.30.61.2-1.31.11.41.3-1.21.0
Cocaine induced anxiety0.30.30.5-0.7-0.7-0.60.5-0.6-0.5-0.60.5-0.0
Post-drug Anxiety3.03.35.0-1.6-0.2-1.81.8-2.0-2.0-2.02.2-2.0
Baseline Anxiety0.60.73.10.61.70.3-0.3-0.1-0.1-0.10.1-1.5
Tail length0.31.11.51.21.21.1-1.21.01.11.0-0.80.4
Length with tail1.45.26.32.51.62.5-2.52.32.52.5-2.41.5
Length without tail1.83.95.42.21.32.2-2.01.92.12.1-2.31.3
Times rat made contact with spout0.91.03.7-0.3-1.60.1-0.20.90.70.7-0.81.9
Lifetime Intake0.40.51.0-0.8-0.5-0.70.8-0.6-0.8-0.61.0-0.2
Liver weight, left0.71.11.80.90.21.0-0.91.31.11.1-0.91.3
Liver weight, right3.15.27.52.72.02.6-2.32.52.42.4-2.01.4
Locomotor activity1.82.84.72.22.21.9-1.71.81.51.6-1.20.1
Locomotor testing distance0.50.81.51.21.21.0-0.91.00.70.9-0.5-0.1
Locomotor testing rearing0.91.31.91.30.51.2-1.21.41.21.3-1.20.9
Locomotion in novel chamber0.60.73.01.11.70.9-0.70.70.40.6-0.0-0.4
Locomotion in novel chamber post-restriction0.10.10.30.2-0.10.3-0.30.20.30.4-0.60.4
Fecal boli incidents, locomotor time 10.40.50.9-0.8-0.4-0.80.6-1.0-0.6-0.90.3-0.7
Change in fecal boli incidents, locomotor task0.00.00.10.10.20.1-0.10.2-0.00.10.40.2
Time >=10cm from walls, locomotor time 12.72.73.61.91.11.8-1.71.81.71.8-1.51.3
Bouts of movement, locomotor time 11.21.42.6-1.1-0.1-1.11.1-1.6-1.1-1.40.7-1.5
Total resting periods, locomotor time 11.71.93.0-1.3-0.3-1.41.4-1.7-1.4-1.61.1-1.6
Rest time, locomotor task time 11.82.03.8-1.8-2.0-1.61.5-1.4-1.2-1.30.9-0.2
Distance moved, locomotor task time 10.30.41.50.51.20.2-0.2-0.2-0.2-0.00.3-1.1
Vertical activity count, locomotor time 10.40.41.00.91.00.7-0.70.50.50.6-0.4-0.1
Time >=10cm from walls, locomotor time 22.72.93.81.70.61.8-1.81.72.01.8-1.91.6
Bouts of movement, locomotor time 20.60.61.5-0.8-0.6-0.70.6-1.2-0.7-0.9-0.2-0.8
Total resting periods, locomotor time 20.60.61.3-0.9-0.7-0.70.7-1.2-0.7-0.9-0.2-0.7
Rest time, locomotor task time 21.41.63.2-1.8-1.5-1.51.4-1.1-1.3-1.31.0-0.2
Distance moved, locomotor task time 20.70.83.41.11.90.6-0.6-0.10.30.2-0.1-1.2
Vertical activity count, locomotor time 22.22.43.92.01.61.7-1.71.21.61.5-1.70.3
Light reinforcement 10.10.21.2-0.5-1.1-0.40.4-0.3-0.2-0.2-0.20.3
Light reinforcement 20.30.42.1-0.7-1.4-0.40.3-0.3-0.1-0.1-0.20.6
Bone: marrow area1.94.15.42.21.52.2-2.32.02.22.0-2.11.4
Bone: maximum diameter2.64.86.22.52.12.4-2.52.22.32.1-2.21.1
Bone: maximum force2.23.85.72.42.32.2-2.31.71.81.7-1.80.4
Bone: maximum moment1.52.54.62.02.21.8-1.91.21.41.3-1.5-0.0
Mean time between licks in bursts0.50.82.0-0.30.3-0.70.8-1.0-0.9-1.00.8-1.4
Mean num. licks in bursts0.20.20.5-0.5-0.7-0.50.4-0.3-0.3-0.40.30.0
Cd content in liver2.22.43.0-1.5-0.6-1.71.6-1.7-1.7-1.71.7-1.5
Co content in liver0.70.82.4-0.50.7-0.60.6-1.0-0.9-1.00.9-1.5
Cu content in liver1.11.36.1-1.3-2.5-1.11.1-0.3-0.5-0.30.31.0
Fe content in liver0.70.92.8-0.1-1.50.2-0.30.80.60.8-1.01.7
K content in liver5.45.412.61.4-1.11.8-1.92.82.52.7-2.23.6
Mg content in liver0.91.03.40.3-0.90.5-0.61.21.01.0-0.61.9
Mn content in liver0.40.41.30.3-0.50.4-0.30.90.50.7-0.41.1
Na content in liver3.43.611.40.4-2.40.9-0.91.91.81.9-1.83.4
Rb content in liver0.30.41.8-0.0-0.80.2-0.30.70.50.6-0.31.4
Se content in liver0.10.10.50.0-0.70.00.10.40.30.3-0.10.7
Sr content in liver1.11.01.41.21.11.1-1.11.01.10.9-1.00.4
Zn content in liver1.01.12.40.6-0.40.9-0.91.21.21.2-1.31.5
Bone: minimum diameter4.38.111.73.43.13.2-3.22.62.92.6-2.81.0
Time in familiar zone, hab. session 10.40.41.4-0.30.4-0.40.2-1.0-0.3-0.8-0.1-1.2
Time in novel zone, hab. session 10.40.41.7-0.1-1.00.1-0.00.70.20.6-0.11.3
Total zone transitions, hab. session 10.50.73.30.71.80.3-0.3-0.1-0.2-0.30.2-1.4
Total locomotion distance, hab. session 11.41.93.21.81.61.6-1.51.31.31.2-1.40.3
Locomotion velocity, hab. session 11.11.53.01.61.71.4-1.31.11.01.0-0.90.2
Time in familiar zone, hab. session 21.01.01.7-0.9-0.1-1.00.9-1.3-1.0-1.21.0-1.2
Time in novel zone, hab. session 21.11.11.71.10.71.2-1.11.31.11.2-0.90.9
Total zone transitions, hab. session 20.10.10.20.40.20.3-0.40.40.30.3-0.30.2
Total locomotion distance, hab. session 20.30.40.60.60.00.5-0.60.80.60.7-0.60.7
Locomotion velocity, hab. session 20.20.20.50.3-0.30.3-0.40.70.50.5-0.40.7
Novel to familiar place preference ratio0.00.00.1-0.1-0.4-0.00.20.1-0.10.1-0.20.2
Novelty place preference0.10.10.2-0.3-0.4-0.30.5-0.1-0.4-0.20.2-0.1
Time in novel zone, NPP test0.10.10.2-0.3-0.2-0.30.5-0.2-0.4-0.30.3-0.3
Total zone transitions, NPP test1.52.24.51.82.11.7-1.71.31.21.3-1.20.1
Total locomotion distance, NPP test1.82.53.81.91.71.8-1.81.61.51.6-1.20.7
Locomotion velocity, NPP test1.82.63.82.01.71.8-1.81.71.61.6-1.20.8
Intraocular pressure0.50.72.61.01.60.8-0.90.40.50.4-0.6-0.6
Delta distance traveled before/after self-admin0.20.20.4-0.5-0.5-0.50.4-0.6-0.3-0.50.0-0.2
Delta ambulatory time before/after self-admin0.30.30.6-0.7-0.6-0.70.6-0.8-0.5-0.70.2-0.3
Parametrial fat weight4.89.312.22.91.03.2-3.13.43.43.4-3.52.8
Pavlov. Cond. lever latency0.50.60.8-0.6-0.1-0.80.8-0.8-0.9-0.90.8-0.9
Pavlov. Cond. magazine entry latency0.00.00.0-0.20.0-0.0-0.0-0.1-0.0-0.1-0.00.0
Pavlov. Cond. change in total contacts0.20.30.5-0.6-0.6-0.60.5-0.4-0.5-0.40.70.0
Pavlov. Cond. index score0.10.10.10.20.30.3-0.40.20.30.2-0.20.2
Pavlov. Cond. latency score0.20.20.30.40.30.5-0.60.50.50.5-0.40.5
Pavlov. Cond. lever contacts0.80.91.30.80.41.0-1.11.01.11.1-0.91.0
Pavlov. Cond. magazine entry number0.00.00.00.0-0.0-0.00.0-0.1-0.0-0.00.0-0.1
Pavlov. Cond. intertrial magazine entries1.82.23.51.2-0.11.4-1.41.71.61.7-1.51.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.40.20.5-0.60.60.60.6-0.50.7
Pavlov. Cond. response bias0.00.00.00.10.20.2-0.20.20.20.2-0.10.2
Pavlov. Cond. lever latency0.00.00.2-0.0-0.20.1-0.1-0.00.10.1-0.50.1
Pavlov. Cond. magazine entry latency0.00.00.20.10.40.1-0.10.10.10.00.2-0.0
Pavlov. Cond. change in total contacts0.50.63.60.81.90.4-0.40.0-0.0-0.10.5-1.0
Pavlov. Cond. index score0.10.10.40.40.60.3-0.40.30.30.20.20.1
Pavlov. Cond. latency score0.10.10.30.20.60.1-0.20.10.10.00.4-0.1
Pavlov. Cond. lever contacts0.10.20.5-0.3-0.0-0.40.4-0.3-0.4-0.40.7-0.4
Pavlov. Cond. magazine entry number0.50.61.4-0.9-1.2-0.80.8-0.7-0.7-0.60.3-0.3
Pavlov. Cond. intertrial magazine entries1.11.53.10.8-0.41.0-1.11.41.21.4-1.41.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.40.50.60.4-0.50.40.50.40.00.2
Pavlov. Cond. response bias0.10.10.60.30.70.2-0.10.10.00.00.4-0.3
Time in closed arm before self-admin0.91.01.70.8-0.10.9-1.01.01.21.1-1.11.3
Time in closed arm after self-admin1.51.62.3-1.5-1.5-1.41.3-1.2-1.2-1.21.1-0.3
Time in open arm before self-admin0.20.31.30.41.10.2-0.2-0.1-0.2-0.10.3-0.9
Time in open arm after self-admin0.80.91.31.00.31.0-0.91.11.01.1-0.81.0
Bone: periosteal estimation2.14.36.02.42.32.3-2.41.92.11.9-2.00.7
Bone: periosteal perimeter2.33.95.62.42.32.2-2.31.72.01.8-2.00.5
Bone: post-yield work2.94.05.31.90.82.1-2.22.12.32.1-2.21.8
Progressive ratio test 1 active lever presses0.20.21.2-0.1-0.40.00.20.60.00.30.71.1
Progressive ratio test 1 breakpoint0.20.20.7-0.1-0.3-0.00.20.5-0.10.20.80.9
Progressive ratio test 1 inactive lever presses0.30.31.2-0.4-0.9-0.20.30.4-0.10.20.71.1
Progressive ratio test 2 active lever presses0.10.10.30.10.20.2-0.00.50.10.30.40.5
Progressive ratio test 2 breakpoint0.10.10.6-0.20.0-0.10.30.2-0.2-0.00.80.3
Progressive ratio test 2 inactive lever presses0.10.10.40.30.60.3-0.10.40.20.30.20.0
Incentive Sensitization - Responses0.30.31.10.61.10.5-0.40.50.30.4-0.1-0.2
Incentive Sensitization - Breakpoint0.20.20.80.40.90.4-0.20.40.20.2-0.0-0.3
Sum of active levers in priming session hrs 5-60.60.62.01.01.40.7-0.60.30.50.3-0.4-0.7
Progressive ratio1.61.93.1-0.90.1-1.21.4-1.5-1.5-1.41.7-1.8
Food seeking constrained by brief footshock0.10.10.20.0-0.10.2-0.30.10.30.3-0.30.4
Seeking ratio, punishment vs. effort1.41.73.00.8-0.01.2-1.41.41.41.3-1.51.7
Retroperitoneal fat weight1.23.85.42.01.02.1-2.02.32.12.2-1.81.8
Reaction time number correct2.02.84.11.50.21.7-1.61.91.72.0-1.91.8
Reaction time mean minus median1.82.44.01.40.71.6-1.71.51.71.6-2.01.4
Reaction time mean minus median AUC0.20.20.70.30.10.5-0.50.40.60.5-0.80.4
Reaction time num false alarms0.50.71.20.90.50.9-0.90.71.00.8-1.10.3
Reaction time num false alarms AUC0.40.61.40.80.50.8-0.90.50.90.7-1.20.2
Reaction time trials correct on left2.02.84.11.50.21.7-1.61.91.72.0-1.91.8
Reaction time trials on left2.33.34.61.70.21.8-1.72.01.92.2-2.01.9
Reaction time mean1.41.93.01.41.01.5-1.51.31.51.4-1.70.9
Reaction time mean AUC1.41.92.81.40.81.5-1.51.41.51.5-1.71.1
Median of all reaction times0.70.91.51.00.71.0-1.00.91.01.0-1.20.6
Reaction time omissions0.50.61.20.6-0.10.7-0.70.90.80.9-1.10.8
Reaction time false alarm rate0.30.41.60.00.8-0.20.1-0.7-0.2-0.60.2-1.3
Reaction time premature initiation rate0.10.10.30.40.60.2-0.20.00.10.1-0.3-0.5
Reaction time premature initiations0.40.61.10.90.30.8-0.80.80.80.9-1.00.5
Std. dev. reaction times2.53.55.61.70.81.9-2.01.92.02.0-2.41.6
Reaction time trials completed2.33.34.61.70.21.8-1.72.01.92.2-2.01.9
Reaction time trials AUC2.02.94.11.60.31.8-1.71.91.82.0-1.91.8
Run reversals in cocaine runway, females1.41.42.3-1.5-1.5-1.31.2-1.2-1.2-1.10.7-0.2
Run reversals in cocaine runway, males0.40.40.50.50.30.7-0.70.60.70.7-0.50.7
Latency to leave start box in cocaine runway8.49.011.9-3.4-3.2-3.33.3-3.1-3.0-3.02.7-1.3
Latency to leave start box in cocaine runway, F8.69.413.9-3.7-3.7-3.43.3-3.1-3.0-2.92.6-0.9
Latency to leave start box in cocaine runway, M0.80.81.4-0.6-0.1-0.81.0-1.0-1.0-1.00.8-1.2
Std. dev. time between licks in bursts0.50.60.9-0.6-0.4-0.80.9-0.7-0.9-0.80.9-0.8
Total sessions with >9 infusions0.80.94.40.1-1.10.4-0.21.10.50.90.22.1
Short access day 1 total inactive lever presses0.30.30.60.60.40.6-0.60.60.70.7-0.40.6
Short access day 10 total inactive lever presses0.60.71.00.80.30.8-0.91.01.00.9-0.90.7
Short access day 1 total infusions0.60.62.40.4-0.40.6-0.60.90.70.9-0.31.6
Short access day 10 total infusions0.00.00.1-0.20.0-0.10.2-0.2-0.2-0.10.4-0.1
Short access total infusions0.30.30.6-0.7-0.8-0.50.6-0.2-0.5-0.20.70.4
Short access day 1 locomotion1.01.12.30.80.11.0-0.91.41.01.2-0.61.5
Short access day 10 total locomotion0.70.82.40.6-0.40.7-0.71.20.91.1-0.31.5
Short access total locomotion1.31.43.50.90.01.1-0.91.61.11.4-0.41.9
One hour access (0.3 mA shock)0.30.41.80.71.30.4-0.30.20.10.1-0.1-1.0
Compulsive drug intake1.01.11.7-1.1-0.6-1.11.0-1.3-1.0-1.20.5-1.1
One hour access (shock baseline)0.50.51.00.81.00.8-0.70.90.60.7-0.30.4
Social response proportion0.60.63.10.81.80.5-0.5-0.10.20.1-0.0-1.1
Social responses1.01.36.41.32.50.8-0.70.10.30.2-0.1-1.6
Social time0.30.41.70.21.0-0.1-0.1-0.6-0.2-0.40.1-1.3
Soleus weight2.16.28.83.02.62.8-2.82.32.52.4-2.41.0
Bone: stiffness1.42.12.71.61.11.6-1.61.51.51.5-1.60.9
Tibialis anterior weight1.86.326.03.15.12.5-2.61.01.41.1-1.1-1.7
Time to tail flick, vehicle, before self-admin0.00.00.1-0.1-0.4-0.10.0-0.20.00.0-0.10.3
Time to tail flick, vehicle, after self-admin3.03.24.91.4-0.01.7-1.81.92.11.9-2.12.2
Time to tail flick, test, before self-admin0.80.81.60.6-0.10.8-0.80.71.00.9-1.31.1
Time to tail flick, test, after self-admin0.00.00.30.00.10.1-0.1-0.10.1-0.0-0.6-0.0
Delta time to tail flick, vehicle, before/after SA1.21.11.61.00.81.1-1.21.11.21.1-1.30.7
Delta time to tail flick, test, before/after SA0.20.10.60.40.80.3-0.30.20.10.1-0.2-0.5
Tibia length3.08.511.83.42.83.3-3.32.92.92.9-2.81.6
Ambulatory time before self-admin1.31.41.71.31.01.3-1.31.31.31.2-1.00.8
Ambulatory time after self-admin0.10.10.10.1-0.10.2-0.20.20.40.2-0.40.4
Bone: tissue strength0.10.10.2-0.4-0.3-0.40.4-0.4-0.5-0.40.3-0.4
Total heroin consumption1.21.44.00.6-0.70.9-0.91.31.11.3-1.12.0
Bone: trabecular number1.11.74.6-0.51.1-0.91.0-1.3-1.4-1.51.5-2.1
Bone: trabecular spacing0.10.21.1-0.4-1.0-0.20.2-0.00.10.0-0.10.6
Bone: trabecular thickness0.30.41.40.01.0-0.20.3-0.5-0.6-0.50.5-1.2
Bone: trabecular tissue density0.81.15.7-1.1-2.4-0.70.80.1-0.30.10.01.3
Water consumed over 24 hours2.63.16.61.1-0.31.5-1.62.11.91.9-1.82.6
Number of responses in last shaping day0.30.31.00.1-0.70.2-0.30.60.40.4-0.41.0