Hub : Genes

Etv2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	XM_039093962.2	0.01	0.01	9.2e-03	0.01	0	0	0	3.2e-02	1.6e-01	1.6e-01	2.7e-01
2	IL	gene expression	Etv2	0.15	0.12	8.9e-03	0.04	0.07	0.07	0.01	4.5e-02	1.0e-02	8.1e-03	1.4e-01
3	Brain	gene expression	Etv2	0.04	0.04	7.8e-04	0.03	0.02	0.01	0.01	1.2e-03	4.5e-03	3.7e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.2	2.0	2.2	1.4	-1.3	-1.5
Area under the delay curve	0.4	0.5	0.8	0.9	-0.0	0.8
BMI with tail	0.2	0.8	1.1	-0.4	1.0	1.0
BMI without tail	0.1	0.2	0.6	0.8	0.0	0.3
Body weight	2.3	10.3	15.8	4.0	-2.9	-2.5
Weight adjusted by age	0.1	0.1	0.2	0.4	-0.3	-0.4
Bone surface	1.0	1.9	3.5	1.9	-1.1	-1.0
Bone volume	1.3	2.3	3.6	1.9	-1.3	-1.3
Breakpoint value in progressive ratio session	0.4	0.4	1.1	1.0	-0.3	0.3
Number of licking bursts	2.3	3.8	4.7	-1.7	1.9	2.2
Context. condit. distance diff. score	0.3	0.3	0.8	-0.0	0.5	0.9
Locomotion velocity, session 1	0.2	0.3	0.4	-0.7	0.2	-0.5
Locomotion distance, session 1	0.2	0.3	0.7	0.8	0.3	0.0
Locomotion velocity, session 2	0.7	0.8	1.2	-1.1	1.0	0.4
Locomotion distance, session 2	2.9	4.0	6.8	-1.4	2.6	1.8
Locomotion velocity, session 3	0.4	0.5	0.9	-0.6	0.9	0.3
Locomotion distance, session 3	0.8	0.9	2.1	1.4	0.5	0.6
Stereotopy head waving bouts, day 3	0.5	0.6	0.8	-0.9	-0.5	-0.9
Stereotopy head waving duration, day 3	0.5	0.7	1.5	-1.2	-0.4	-0.6
Locomotion velocity, session 7	0.2	0.2	0.3	0.3	0.5	0.4
Locomotion distance, session 7	0.1	0.1	0.1	0.2	0.2	-0.4
Stereotopy head waving bouts, day 7	1.9	2.2	2.8	-1.3	1.4	1.7
Stereotopy head waving duration, day 7	1.5	1.9	2.4	-1.6	1.2	1.3
Locomotion velocity, session 8	4.1	4.9	5.7	-2.1	2.4	2.2
Locomotion distance, session 8	2.3	3.4	4.8	-1.0	2.2	2.0
Degree of sensitization distance	0.5	0.5	0.8	-0.5	-0.7	-0.9
Degree of sensitization stereotypy	2.1	2.3	3.7	-1.0	1.5	1.9
Conditioned locomotion	1.0	1.1	1.2	-1.0	1.1	1.1
Cocaine response after cond. corrected	0.5	0.6	1.2	-0.4	-0.7	-1.1
Cocaine response after cond. not corrected	1.1	1.3	2.7	-0.4	-1.1	-1.6
Cocaine response before conditioning	1.2	1.4	1.6	1.2	-1.3	-1.1
Saline control response	0.2	0.2	0.5	-0.7	0.2	-0.4
Bone: connectivity density	0.3	0.4	0.7	0.9	-0.5	-0.5
Bone: cortical apparent density	1.4	1.9	2.5	-1.6	1.6	0.8
Bone: cortical area	1.5	2.3	2.5	1.6	-1.5	-1.5
Bone: cortical porosity	2.3	2.5	4.7	-0.8	1.5	2.2
Bone: cortical porosity	3.2	3.5	6.0	-1.1	1.8	2.4
Bone: cortical thickness	0.9	1.4	1.7	1.1	-1.2	-1.3
Bone: cortical thickness	0.3	0.3	0.7	-0.8	0.5	0.0
Bone: cortical tissue density	1.7	2.3	3.1	-1.7	1.7	1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.2	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.0	-0.5	-0.6
Condit. Reinf. active responses	2.2	2.8	3.4	-1.5	1.9	1.6
Condit. Reinf. inactive responses	4.6	5.6	7.3	-2.0	2.7	2.4
Incentive salience index mean	0.3	0.3	0.5	-0.2	0.7	0.7
Condit. Reinf. lever presses	0.3	0.4	0.8	0.1	0.5	0.9
Condit. Reinf. active minus inactive responses	0.7	0.9	1.4	1.2	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.1	-0.1
Condit. Reinf. active responses	1.7	2.3	4.4	2.1	-1.3	-1.0
Condit. Reinf. inactive responses	1.4	1.8	4.5	2.1	-0.9	-0.3
Condit. Reinf. lever presses	5.9	8.2	12.6	3.5	-2.8	-2.1
Condit. Reinf. lever reinforcers received	1.8	2.5	5.4	2.3	-1.2	-0.8
Conditioned reinforcement - actives	0.3	0.6	1.2	-1.1	0.7	0.1
Conditioned reinforcement - inactives	1.1	1.7	3.8	0.2	1.1	2.0
Conditioned locomotion	2.1	2.8	3.7	-1.9	1.7	1.4
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.2	-0.2	0.1
Patch foraging indifference point AUC	0.4	0.5	0.8	-0.9	0.7	0.6
Delay disc. indifference point, 0s delay	1.1	1.2	2.2	0.1	1.2	1.5
Delay disc. indifference point, 16s delay	0.6	0.7	1.0	1.0	-0.1	1.0
Delay disc. indifference point, 2s delay	0.2	0.3	0.6	0.8	0.2	0.4
Delay disc. indifference point, 24s delay	0.9	1.0	2.5	1.6	-0.7	0.1
Delay disc. indifference point, 4s delay	0.4	0.5	1.2	0.3	0.3	1.1
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	0.9	-0.6	0.1
Indifference point function ln k	0.1	0.1	0.2	0.3	0.0	-0.5
Indifference point function log k	0.1	0.1	0.2	0.3	0.0	-0.5
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.3	-0.2	0.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.1	-0.3	-0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.3	0.4	0.7
Patch foraging total patch changes 24 sec	0.2	0.4	1.0	1.0	-0.4	0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.1	-0.2	-0.1
Patch foraging time to switch 0 sec	0.2	0.4	1.1	-1.1	0.1	0.0
Patch foraging water rate 0 sec	0.5	1.0	1.5	-0.8	1.2	1.0
Patch foraging water rate 12 sec	0.3	0.6	1.6	1.3	-0.4	-0.0
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.1	0.3	0.1
Patch foraging water rate 24 sec	1.7	2.4	3.8	-0.0	1.8	1.9
Patch foraging water rate 6 sec	0.5	0.7	1.8	1.4	0.0	0.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.6	1.3	0.1	0.8
Distance traveled before self-admin	0.0	0.0	0.1	-0.2	0.3	0.1
Distance traveled after self-admin	1.7	2.2	2.9	1.7	-1.5	-1.1
Extensor digitorum longus weight	0.1	0.4	0.8	-0.7	-0.0	-0.9
Bone: elastic displacement	0.3	0.3	0.5	0.1	-0.7	-0.7
Bone: elastic work	1.9	2.5	3.0	1.7	-1.7	-1.3
Bone: endosteal estimation	1.1	2.4	3.2	1.8	-1.5	-1.3
Bone: endosteal perimeter	0.5	1.2	2.2	1.5	-0.9	-0.7
Epididymis fat weight	0.0	0.0	0.0	0.2	0.2	-0.2
Delta time in closed arm before/after self-admin	1.1	1.0	1.7	1.3	-1.0	-0.7
Delta time in open arm before/after self-admin	0.4	0.4	1.0	-1.0	0.4	-0.1
Diff in mean of infusions in LGA sessions	1.3	1.6	2.2	-1.0	1.2	1.5
Delay discount exponential model param	0.5	0.5	1.1	-1.1	0.3	-0.6
Extinction: sum of active levers before priming	4.5	4.9	5.4	2.1	-2.3	-2.2
Active lever presses in extinction session 6	4.3	4.3	6.9	1.0	-2.2	-2.6
Bone: final force	1.6	2.5	4.1	2.0	-1.5	-1.0
Bone: final moment	2.0	3.2	4.8	2.2	-1.7	-1.3
Food consumed during 24 hour testing period	0.4	0.5	1.1	1.0	0.1	0.6
Glucose	0.3	0.4	0.9	-0.4	-0.4	-1.0
Heart weight	0.1	0.2	0.4	0.4	0.2	0.6
Delay discount hyperbolic model param	0.4	0.4	0.8	-0.9	0.1	-0.7
Intermittent access intake day 1-15 change	0.9	1.9	2.6	1.6	-1.3	-1.1
Intermittent access intake escalation	0.8	1.7	1.8	1.3	-1.2	-1.3
Intermittent access intake escalation 2	1.9	2.1	2.4	1.4	-1.6	-1.4
Intermitt. access day 1 inactive lever presses	0.7	2.6	6.3	2.5	-1.2	0.3
Intermitt. access day 15 inactive lever presses	0.5	1.0	1.8	1.2	0.1	1.3
Intermitt. access escalation Index	0.6	0.9	1.4	-0.6	1.2	1.0
Intermittent access day 1 total infusions	3.5	5.6	7.0	-1.8	2.6	2.6
Intermittent access day 15 total infusions	0.6	0.9	1.2	-0.4	1.1	1.1
Intermittent access terminal intake (last 3 days)	1.5	2.0	3.2	-0.7	1.6	1.8
Intermittent access total infusions	2.2	2.6	3.5	-1.0	1.8	1.9
Intermittent access day 1 locomotion	4.4	5.6	8.7	-1.2	2.5	3.0
Intermittent access day 15 total locomotion	0.7	1.3	2.4	-0.3	1.3	1.5
Intermittent access total locomotion	3.1	3.7	4.6	-1.4	2.1	2.1
Intermittent access standard deviation	1.0	2.1	4.7	2.2	-1.2	-0.4
Left kidney weight	2.0	9.2	10.7	3.3	-2.9	-2.9
Right kidney weight	2.6	12.0	13.1	3.5	-3.3	-3.6
Cocaine induced anxiety	0.0	0.0	0.0	-0.0	-0.1	-0.2
Post-drug Anxiety	0.1	0.1	0.3	-0.1	0.1	0.5
Baseline Anxiety	0.4	0.4	1.2	0.4	0.2	1.1
Tail length	3.9	15.1	22.0	4.7	-3.7	-3.1
Length with tail	5.6	24.4	35.4	5.9	-4.8	-3.9
Length without tail	2.9	9.3	12.9	3.6	-2.9	-2.6
Times rat made contact with spout	0.3	0.4	0.8	-0.1	-0.5	-0.9
Lifetime Intake	1.7	2.1	2.7	-1.2	1.6	1.5
Liver weight, left	0.1	0.2	0.6	-0.8	0.3	0.1
Liver weight, right	0.1	0.2	0.4	-0.6	0.3	-0.3
Locomotor activity	0.5	0.8	1.4	-0.9	-0.5	-1.2
Locomotor testing distance	0.4	0.7	1.6	-1.3	0.1	-0.7
Locomotor testing rearing	0.9	1.9	3.9	-2.0	1.3	0.3
Locomotion in novel chamber	0.1	0.1	0.4	-0.6	-0.0	-0.1
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	-0.1	0.2
Fecal boli incidents, locomotor time 1	1.5	2.1	3.9	-2.0	1.2	1.1
Change in fecal boli incidents, locomotor task	1.1	1.1	1.6	0.3	-1.3	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	-0.4	0.1
Bouts of movement, locomotor time 1	0.4	0.5	0.9	0.6	0.6	0.9
Total resting periods, locomotor time 1	0.4	0.4	0.7	0.5	0.5	0.9
Rest time, locomotor task time 1	0.9	1.1	1.4	-1.1	0.8	1.2
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.2	0.5	-0.0
Vertical activity count, locomotor time 1	0.4	1.0	2.0	1.4	-0.8	-0.7
Time >=10cm from walls, locomotor time 2	0.9	1.4	1.6	-1.1	1.1	1.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	0.0	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	0.0	0.1
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	0.1	0.5
Distance moved, locomotor task time 2	0.4	0.5	1.0	-0.5	1.0	0.5
Vertical activity count, locomotor time 2	0.2	0.3	0.8	0.9	-0.1	-0.1
Light reinforcement 1	0.2	0.4	0.6	-0.3	0.8	0.8
Light reinforcement 2	1.6	2.5	3.3	-1.8	1.7	1.1
Bone: marrow area	1.2	2.6	3.3	1.8	-1.6	-1.4
Bone: maximum diameter	1.0	1.9	2.7	1.6	-1.4	-1.1
Bone: maximum force	2.2	3.9	6.6	2.6	-1.8	-1.4
Bone: maximum moment	2.5	4.5	7.1	2.7	-1.9	-1.6
Mean time between licks in bursts	0.3	0.6	1.0	-0.3	1.0	0.9
Mean num. licks in bursts	2.5	3.9	5.5	1.5	-2.0	-2.3
Cd content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Co content in liver	0.2	0.2	0.5	-0.7	0.0	-0.0
Cu content in liver	0.7	0.9	1.5	1.2	-0.8	-0.7
Fe content in liver	0.1	0.2	0.4	-0.7	0.1	0.3
K content in liver	0.0	0.0	0.0	0.1	-0.1	0.0
Mg content in liver	0.2	0.2	0.5	-0.7	-0.0	-0.3
Mn content in liver	0.4	0.4	0.4	-0.7	-0.6	-0.6
Na content in liver	0.4	0.4	0.5	0.7	-0.7	-0.4
Rb content in liver	0.3	0.4	1.0	-0.2	0.3	1.0
Se content in liver	1.9	2.2	5.3	-2.3	1.1	0.4
Sr content in liver	0.2	0.1	0.2	-0.4	-0.4	-0.3
Zn content in liver	0.7	0.8	1.8	-1.3	0.6	0.4
Bone: minimum diameter	1.3	2.3	5.1	2.3	-1.2	-0.6
Time in familiar zone, hab. session 1	1.4	1.4	3.0	0.5	-0.9	-1.7
Time in novel zone, hab. session 1	2.5	2.5	4.7	-1.0	1.3	2.2
Total zone transitions, hab. session 1	0.3	0.4	0.7	-0.1	0.8	0.6
Total locomotion distance, hab. session 1	0.5	0.7	1.3	1.2	-0.7	-0.3
Locomotion velocity, hab. session 1	0.4	0.6	0.8	0.9	-0.8	-0.6
Time in familiar zone, hab. session 2	2.4	2.6	4.1	1.3	-2.0	-1.4
Time in novel zone, hab. session 2	1.0	1.1	1.7	-0.9	1.3	0.8
Total zone transitions, hab. session 2	3.1	4.0	5.2	-1.9	2.3	1.8
Total locomotion distance, hab. session 2	0.5	0.6	1.3	-0.2	0.7	1.2
Locomotion velocity, hab. session 2	0.4	0.5	1.0	-0.3	0.7	1.0
Novel to familiar place preference ratio	0.1	0.1	0.1	0.4	-0.1	0.0
Novelty place preference	0.0	0.0	0.1	0.2	0.0	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	0.2	0.3
Total zone transitions, NPP test	0.2	0.2	0.6	-0.3	0.8	-0.1
Total locomotion distance, NPP test	2.0	2.8	3.5	1.9	-1.5	-1.6
Locomotion velocity, NPP test	2.2	3.1	3.9	2.0	-1.7	-1.6
Intraocular pressure	0.1	0.2	0.4	-0.2	0.1	0.6
Delta distance traveled before/after self-admin	2.4	2.6	3.6	1.9	-1.6	-1.2
Delta ambulatory time before/after self-admin	1.8	2.2	3.7	1.9	-1.4	-1.0
Parametrial fat weight	0.8	1.9	4.0	-0.4	-1.3	-2.0
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.2	-0.6	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	-0.6	0.7	0.4
Pavlov. Cond. change in total contacts	1.3	1.4	2.2	-0.4	1.3	1.5
Pavlov. Cond. index score	0.3	0.3	0.5	-0.5	0.7	0.6
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.4	0.7	0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	0.2	0.4
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	0.4	-0.7	-0.6
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	-1.2	1.1	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.6	0.8	0.7
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.3	0.2	-0.1
Pavlov. Cond. lever latency	3.8	5.1	10.0	-3.2	2.0	1.2
Pavlov. Cond. magazine entry latency	2.8	3.3	5.6	2.4	-1.9	-0.9
Pavlov. Cond. change in total contacts	4.6	7.4	14.0	3.7	-2.5	-1.3
Pavlov. Cond. index score	4.9	6.5	11.6	3.4	-2.5	-1.4
Pavlov. Cond. latency score	4.2	5.5	10.2	3.2	-2.2	-1.2
Pavlov. Cond. lever contacts	4.0	5.6	10.9	3.3	-2.1	-1.2
Pavlov. Cond. magazine entry number	4.0	5.0	8.1	-2.8	2.2	1.5
Pavlov. Cond. intertrial magazine entries	0.8	1.2	2.2	-1.5	0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.5	10.9	3.3	-2.5	-1.5
Pavlov. Cond. response bias	4.6	6.3	12.4	3.5	-2.2	-1.3
Time in closed arm before self-admin	1.9	2.5	2.9	-1.4	1.7	1.6
Time in closed arm after self-admin	0.5	0.6	1.3	0.3	0.6	1.1
Time in open arm before self-admin	6.0	6.6	7.8	2.7	-2.8	-2.2
Time in open arm after self-admin	1.9	2.1	2.8	0.9	-1.6	-1.7
Bone: periosteal estimation	1.9	3.9	4.9	2.2	-1.9	-1.8
Bone: periosteal perimeter	1.1	1.9	2.0	1.4	-1.4	-1.3
Bone: post-yield work	0.7	1.0	2.9	1.7	-0.5	-0.0
Progressive ratio test 1 active lever presses	0.6	0.8	1.4	-0.1	0.9	1.2
Progressive ratio test 1 breakpoint	0.6	0.8	1.5	-0.1	0.9	1.2
Progressive ratio test 1 inactive lever presses	1.9	2.8	5.8	0.2	1.6	2.4
Progressive ratio test 2 active lever presses	0.5	0.6	0.9	-0.7	0.9	0.6
Progressive ratio test 2 breakpoint	0.7	0.8	1.1	-0.8	1.1	0.7
Progressive ratio test 2 inactive lever presses	1.2	2.0	4.3	0.3	1.3	2.1
Incentive Sensitization - Responses	0.6	0.9	1.2	-1.0	1.1	0.6
Incentive Sensitization - Breakpoint	0.6	0.8	1.2	-1.0	1.1	0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.4	0.2	0.1
Progressive ratio	0.1	0.1	0.3	-0.1	0.3	0.5
Food seeking constrained by brief footshock	1.9	2.3	3.7	1.9	-1.5	-0.9
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	0.9	-0.5	-0.2
Retroperitoneal fat weight	0.7	3.1	6.7	-1.2	-1.1	-2.6
Reaction time number correct	0.0	0.1	0.1	0.1	-0.1	-0.4
Reaction time mean minus median	0.2	0.6	0.7	0.8	-0.8	-0.7
Reaction time mean minus median AUC	0.6	1.6	1.8	1.2	-1.4	-1.2
Reaction time num false alarms	0.7	1.0	1.4	-1.2	0.8	0.9
Reaction time num false alarms AUC	0.7	1.1	1.8	-1.3	0.8	0.9
Reaction time trials correct on left	0.0	0.1	0.1	0.1	-0.1	-0.4
Reaction time trials on left	0.0	0.1	0.2	0.1	-0.1	-0.4
Reaction time mean	0.1	0.2	0.3	0.6	-0.3	-0.3
Reaction time mean AUC	0.1	0.2	0.3	0.5	-0.4	-0.4
Median of all reaction times	0.0	0.0	0.0	0.2	0.1	0.0
Reaction time omissions	0.2	0.3	0.7	-0.2	-0.3	-0.8
Reaction time false alarm rate	0.6	0.9	1.2	-1.1	0.7	1.0
Reaction time premature initiation rate	0.3	0.5	1.1	0.0	0.5	1.1
Reaction time premature initiations	0.2	0.3	0.8	-0.0	0.5	0.9
Std. dev. reaction times	0.3	0.6	1.0	1.0	-0.7	-0.5
Reaction time trials completed	0.0	0.1	0.2	0.1	-0.1	-0.4
Reaction time trials AUC	0.1	0.1	0.4	-0.0	-0.2	-0.6
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.9	-0.3	-0.1
Run reversals in cocaine runway, males	2.4	2.4	4.0	0.2	-1.7	-2.0
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.2	0.4	0.5
Latency to leave start box in cocaine runway, F	0.4	0.4	0.8	0.0	0.8	0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.2	0.2	0.1
Std. dev. time between licks in bursts	1.0	1.3	2.8	-0.1	1.0	1.7
Total sessions with >9 infusions	0.7	0.9	1.7	-1.3	0.9	0.3
Short access day 1 total inactive lever presses	1.9	2.4	4.7	0.3	1.6	2.2
Short access day 10 total inactive lever presses	0.4	1.0	2.1	1.4	0.2	0.9
Short access day 1 total infusions	0.2	0.3	0.4	-0.4	0.7	0.6
Short access day 10 total infusions	0.4	0.5	0.6	-0.8	0.8	0.5
Short access total infusions	0.7	0.9	1.4	-1.2	1.0	0.6
Short access day 1 locomotion	0.8	1.0	1.1	-1.0	1.1	1.0
Short access day 10 total locomotion	0.3	0.5	1.1	0.4	0.6	1.1
Short access total locomotion	1.6	1.9	2.1	-1.3	1.5	1.4
One hour access (0.3 mA shock)	0.6	0.7	1.4	0.6	0.6	1.2
Compulsive drug intake	0.4	0.5	1.0	-0.1	0.7	1.0
One hour access (shock baseline)	0.2	0.3	0.6	-0.0	0.6	0.8
Social response proportion	0.8	0.9	1.9	1.4	-0.9	-0.3
Social responses	0.1	0.1	0.3	0.5	-0.4	0.0
Social time	0.7	1.0	2.5	1.6	-0.6	-0.2
Soleus weight	0.0	0.0	0.1	-0.1	-0.2	-0.3
Bone: stiffness	0.9	1.5	2.9	1.7	-0.9	-0.8
Tibialis anterior weight	0.3	0.9	2.1	-0.3	-0.6	-1.4
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.5	-0.6	0.7	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	-0.6	-0.1
Time to tail flick, test, before self-admin	1.1	1.1	1.8	-0.1	1.3	1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.2	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	0.9	1.0	-0.9	-0.4
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.6	-0.7	-0.9
Tibia length	2.1	5.9	9.6	3.1	-2.1	-1.9
Ambulatory time before self-admin	0.0	0.0	0.1	0.0	0.1	0.3
Ambulatory time after self-admin	2.9	3.4	6.0	2.5	-1.8	-1.0
Bone: tissue strength	1.4	1.4	3.6	1.9	-0.9	0.1
Total heroin consumption	0.3	0.3	0.6	0.4	0.4	0.8
Bone: trabecular number	1.2	2.0	3.7	1.9	-1.2	-1.0
Bone: trabecular spacing	0.6	0.8	1.4	0.4	-1.2	-0.9
Bone: trabecular thickness	0.0	0.0	0.1	-0.0	0.3	-0.0
Bone: trabecular tissue density	0.9	1.3	2.3	-1.5	-0.3	-1.2
Water consumed over 24 hours	0.7	1.0	1.1	1.1	-0.9	-1.0
Number of responses in last shaping day	0.0	0.0	0.1	0.0	0.3	0.1