Hub : Genes

Ervk-21l3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Ervk-21l3 0.56 0.15 0.0e+00 0.34 0.33 0.35 0.36 3.2e-15 1.3e-14 1.5e-15 7.8e-16
2 IL gene expression Ervk-21l3 0.38 0.14 6.8e-05 0.06 0.12 0.11 0.15 1.2e-02 9.0e-04 1.6e-03 1.9e-04
3 BLA gene expression Ervk-21l3 0.78 0 0.0e+00 0.45 0.35 0.53 0.5 4.4e-26 1.6e-19 2.4e-32 6.4e-30
4 PL gene expression Ervk-21l3 0.48 0.1 0.0e+00 0.45 0.39 0.5 0.42 2.0e-54 3.8e-45 4.1e-63 1.7e-49
5 Brain gene expression Ervk-21l3 0.55 0.12 0.0e+00 0.42 0.46 0.46 0.47 4.5e-42 4.6e-47 6.5e-48 1.1e-48
6 LHb gene expression Ervk-21l3 0.4 0.14 1.9e-05 0.22 0.1 0.16 -0 6.5e-06 2.4e-03 1.4e-04 4.5e-01
7 OFC gene expression Ervk-21l3 0.5 0.14 2.2e-07 0.2 0.22 0.23 0.24 1.3e-05 7.3e-06 4.0e-06 1.9e-06
8 NAcc gene expression Ervk-21l3 0.4 0.1 0.0e+00 0.38 0.39 0.39 0.39 2.1e-60 1.3e-62 7.1e-64 2.1e-63
9 pVTA gene expression Ervk-21l3 0.55 0.15 0.0e+00 0.47 0.45 0.46 0.46 1.6e-41 7.2e-40 9.1e-41 5.7e-41
10 RMTg gene expression Ervk-21l3 0.41 0.16 6.6e-06 0.22 0.04 0.14 -0.01 1.8e-06 3.6e-02 1.6e-04 9.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.13.75.02.22.12.21.92.22.01.91.61.41.4
Area under the delay curve0.20.20.4-0.30.40.50.40.50.60.50.50.3-0.0
BMI with tail1.03.54.9-2.2-1.7-2.0-1.8-2.0-1.5-1.7-1.6-2.0-2.1
BMI without tail0.10.20.4-0.20.60.30.40.40.60.60.40.20.2
Body weight0.00.10.30.3-0.1-0.5-0.3-0.5-0.3-0.2-0.2-0.3-0.3
Weight adjusted by age0.20.40.7-0.9-0.7-0.6-0.6-0.6-0.5-0.7-0.4-0.5-0.5
Bone surface3.25.87.12.42.32.72.52.62.12.32.42.52.5
Bone volume2.95.36.62.42.12.62.32.52.02.22.22.32.3
Breakpoint value in progressive ratio session1.82.13.30.3-1.2-1.6-1.3-1.6-1.3-1.5-1.6-1.7-1.8
Number of licking bursts0.30.41.00.81.00.40.60.51.00.80.40.10.1
Context. condit. distance diff. score0.50.61.3-1.1-0.6-1.0-0.7-0.9-0.5-0.5-0.5-0.7-0.8
Locomotion velocity, session 11.11.21.51.21.21.11.21.10.91.11.01.11.1
Locomotion distance, session 10.10.10.60.80.60.10.30.10.40.30.20.00.1
Locomotion velocity, session 20.70.81.50.81.20.91.00.91.01.10.80.70.6
Locomotion distance, session 20.10.10.30.40.1-0.6-0.2-0.4-0.1-0.1-0.4-0.5-0.4
Locomotion velocity, session 30.10.20.2-0.50.10.40.40.30.30.30.50.50.5
Locomotion distance, session 34.34.65.60.92.32.22.32.22.22.42.32.12.2
Stereotopy head waving bouts, day 30.20.21.2-1.1-0.20.20.10.30.00.20.50.60.6
Stereotopy head waving duration, day 30.10.21.1-1.0-0.4-0.3-0.4-0.2-0.2-0.3-0.1-0.2-0.2
Locomotion velocity, session 70.20.30.50.00.50.40.60.40.70.50.60.50.5
Locomotion distance, session 70.30.30.80.90.70.50.60.40.50.60.40.40.5
Stereotopy head waving bouts, day 71.51.72.2-0.11.31.31.31.51.41.51.51.31.2
Stereotopy head waving duration, day 71.51.82.40.41.51.51.31.51.61.51.41.21.2
Locomotion velocity, session 80.00.10.30.6-0.0-0.3-0.0-0.2-0.1-0.1-0.1-0.1-0.0
Locomotion distance, session 80.20.20.6-0.00.0-0.7-0.4-0.6-0.0-0.2-0.4-0.7-0.7
Degree of sensitization distance1.71.82.30.1-1.3-1.5-1.4-1.5-1.4-1.5-1.5-1.3-1.4
Degree of sensitization stereotypy1.11.21.60.21.21.11.11.21.21.31.21.01.0
Conditioned locomotion0.00.10.20.50.10.20.20.10.10.10.10.20.2
Cocaine response after cond. corrected1.11.31.8-0.2-1.1-1.2-1.1-1.4-1.1-1.2-1.2-1.3-1.3
Cocaine response after cond. not corrected1.21.41.9-0.2-1.1-1.2-1.1-1.3-1.1-1.2-1.3-1.4-1.4
Cocaine response before conditioning0.60.71.00.41.01.00.90.90.90.90.80.70.8
Saline control response0.71.05.02.21.40.40.70.50.90.90.30.10.2
Bone: connectivity density5.07.89.82.83.03.12.83.12.92.82.52.32.3
Bone: cortical apparent density0.20.30.6-0.60.70.60.40.50.70.70.50.10.0
Bone: cortical area0.10.20.40.60.50.10.40.20.40.40.40.50.4
Bone: cortical porosity1.01.11.7-0.8-1.3-1.2-1.0-1.2-1.3-1.1-0.9-0.6-0.6
Bone: cortical porosity0.30.30.7-0.4-0.8-0.8-0.5-0.7-0.8-0.6-0.30.00.0
Bone: cortical thickness0.40.71.2-1.0-0.7-1.1-0.8-0.9-0.7-0.6-0.6-0.7-0.8
Bone: cortical thickness2.12.56.0-0.5-0.7-1.6-1.6-1.5-0.7-1.2-1.8-2.4-2.4
Bone: cortical tissue density0.30.40.8-0.50.80.70.60.70.90.80.70.30.2
Condit. Reinf. active minus inactive responses1.71.93.0-0.61.51.01.51.21.41.71.71.51.5
Condit. Reinf. active-inactive response ratio0.20.20.4-0.60.5-0.10.40.10.40.60.50.30.3
Condit. Reinf. active responses2.02.53.6-0.21.71.41.61.61.61.91.81.61.6
Condit. Reinf. inactive responses2.63.14.01.41.72.01.81.91.81.71.81.81.7
Incentive salience index mean3.74.66.00.12.22.02.32.22.12.52.42.42.3
Condit. Reinf. lever presses3.75.16.90.52.12.42.42.42.12.42.52.62.5
Condit. Reinf. active minus inactive responses0.40.51.10.40.40.50.70.50.50.50.81.01.0
Condit. Reinf. active-inactive response ratio0.30.30.9-0.6-0.9-0.5-0.5-0.6-0.6-0.8-0.4-0.2-0.2
Condit. Reinf. active responses0.10.10.40.60.20.10.20.10.30.10.30.40.3
Condit. Reinf. inactive responses0.20.30.50.4-0.2-0.6-0.6-0.6-0.4-0.4-0.6-0.6-0.7
Condit. Reinf. lever presses0.00.00.0-0.1-0.2-0.2-0.2-0.2-0.1-0.2-0.0-0.1-0.1
Condit. Reinf. lever reinforcers received0.00.00.20.40.10.00.10.00.10.00.20.30.2
Conditioned reinforcement - actives0.00.00.0-0.1-0.2-0.1-0.2-0.2-0.1-0.2-0.1-0.1-0.1
Conditioned reinforcement - inactives0.00.00.1-0.3-0.3-0.1-0.2-0.2-0.2-0.2-0.10.10.1
Conditioned locomotion0.00.00.1-0.10.10.20.10.10.10.10.30.30.3
Patch foraging indifference point 0 sec0.30.61.30.40.50.50.70.60.60.71.11.11.1
Patch foraging indifference point AUC0.20.32.01.40.40.50.30.30.60.10.10.20.1
Delay disc. indifference point, 0s delay1.01.11.41.00.91.11.21.10.90.91.01.01.0
Delay disc. indifference point, 16s delay1.41.52.4-1.0-1.1-1.3-1.3-1.2-1.1-1.2-1.3-1.3-1.6
Delay disc. indifference point, 2s delay0.20.21.4-1.2-0.3-0.2-0.2-0.2-0.1-0.1-0.1-0.3-0.5
Delay disc. indifference point, 24s delay0.00.00.1-0.3-0.1-0.1-0.1-0.10.0-0.00.20.1-0.1
Delay disc. indifference point, 4s delay1.51.62.20.21.31.51.41.51.41.41.41.21.0
Delay disc. indifference point, 8s delay0.40.40.9-0.20.70.80.70.70.90.70.80.50.3
Indifference point function ln k0.20.42.0-1.40.10.10.30.30.10.50.70.70.7
Indifference point function log k0.20.42.0-1.40.10.10.30.30.10.50.70.70.7
Patch foraging total patch changes 0 sec0.10.20.60.00.10.10.30.20.20.30.70.80.7
Patch foraging total patch changes 12 sec1.52.03.11.81.61.21.31.21.71.41.41.21.2
Patch foraging total patch changes 18 sec1.72.66.42.51.71.51.51.41.71.41.41.41.3
Patch foraging total patch changes 24 sec1.52.63.61.91.51.51.51.51.61.51.71.71.6
Patch foraging total patch changes 6 sec0.20.31.01.00.40.40.40.30.70.30.40.30.2
Patch foraging time to switch 0 sec0.00.00.20.30.4-0.00.00.10.10.3-0.1-0.0-0.0
Patch foraging water rate 0 sec0.10.20.5-0.0-0.7-0.3-0.4-0.5-0.6-0.6-0.4-0.2-0.2
Patch foraging water rate 12 sec0.10.30.6-0.80.30.70.60.60.50.50.60.40.4
Patch foraging water rate 18 sec2.03.04.10.11.51.91.81.91.61.82.01.92.0
Patch foraging water rate 24 sec0.91.31.9-0.30.91.21.21.21.01.11.41.21.2
Patch foraging water rate 6 sec1.72.45.12.31.71.61.61.51.51.51.21.21.3
Seeking ratio, delayed vs. immediate footshock0.50.62.4-1.5-0.5-0.6-0.7-0.6-0.4-0.5-0.6-0.9-0.8
Distance traveled before self-admin0.60.81.8-1.3-1.0-0.8-1.0-0.8-1.0-0.9-0.7-0.6-0.6
Distance traveled after self-admin0.81.01.9-1.4-1.1-0.9-1.1-0.9-1.0-1.0-0.8-0.8-0.8
Extensor digitorum longus weight0.41.72.4-0.6-1.3-1.5-1.3-1.5-1.3-1.4-1.4-1.2-1.3
Bone: elastic displacement0.10.10.3-0.6-0.00.10.20.1-0.00.20.40.50.6
Bone: elastic work0.81.02.0-1.4-1.1-1.2-0.9-1.1-1.1-1.0-0.8-0.6-0.7
Bone: endosteal estimation0.10.11.31.10.2-0.10.0-0.10.20.0-0.2-0.1-0.2
Bone: endosteal perimeter0.81.82.91.71.31.01.31.01.31.31.31.51.5
Epididymis fat weight0.00.10.30.40.20.20.30.20.20.30.40.50.5
Delta time in closed arm before/after self-admin0.00.00.4-0.6-0.00.00.00.00.10.10.1-0.1-0.0
Delta time in open arm before/after self-admin0.40.43.82.00.2-0.10.0-0.10.0-0.1-0.3-0.1-0.1
Diff in mean of infusions in LGA sessions0.10.10.40.60.40.10.20.20.20.2-0.0-0.1-0.0
Delay discount exponential model param0.30.30.60.3-0.6-0.6-0.6-0.6-0.8-0.6-0.6-0.4-0.1
Extinction: sum of active levers before priming0.20.21.9-1.40.10.10.10.10.10.30.30.10.0
Active lever presses in extinction session 60.50.50.8-0.70.40.70.60.70.60.70.90.80.7
Bone: final force0.10.20.30.4-0.4-0.6-0.4-0.5-0.5-0.4-0.5-0.3-0.3
Bone: final moment0.10.10.30.2-0.3-0.5-0.4-0.4-0.4-0.4-0.4-0.2-0.3
Food consumed during 24 hour testing period1.72.49.03.01.91.31.31.41.71.40.80.60.6
Glucose0.30.50.90.4-0.9-0.8-0.7-0.8-0.9-0.9-0.6-0.3-0.3
Heart weight0.10.21.0-1.00.30.00.00.10.50.30.1-0.4-0.4
Delay discount hyperbolic model param0.40.51.00.3-0.8-0.8-0.7-0.8-1.0-0.8-0.8-0.4-0.2
Intermittent access intake day 1-15 change1.32.73.61.91.71.61.71.71.61.71.51.51.6
Intermittent access intake escalation0.91.82.11.51.41.31.41.31.31.31.21.21.3
Intermittent access intake escalation 21.92.22.81.71.51.41.51.41.51.41.31.41.5
Intermitt. access day 1 inactive lever presses0.31.32.40.40.81.21.11.10.91.01.21.61.5
Intermitt. access day 15 inactive lever presses0.50.91.3-1.1-1.2-1.0-1.0-1.0-0.9-1.1-0.9-0.8-0.7
Intermitt. access escalation Index0.10.20.3-0.40.40.40.60.40.40.50.60.50.3
Intermittent access day 1 total infusions1.62.63.9-2.0-1.7-1.6-1.7-1.6-1.6-1.6-1.5-1.3-1.3
Intermittent access day 15 total infusions0.20.30.9-0.9-0.6-0.6-0.6-0.6-0.6-0.5-0.5-0.4-0.3
Intermittent access terminal intake (last 3 days)0.40.50.9-1.0-0.8-0.7-0.8-0.7-0.7-0.7-0.6-0.4-0.3
Intermittent access total infusions1.11.31.7-1.3-1.3-1.2-1.3-1.1-1.2-1.1-1.1-0.9-0.8
Intermittent access day 1 locomotion0.70.92.5-1.6-0.9-0.9-0.9-0.9-0.9-0.8-0.7-0.7-0.7
Intermittent access day 15 total locomotion1.01.92.3-1.2-1.4-1.5-1.5-1.4-1.5-1.4-1.4-1.2-1.1
Intermittent access total locomotion2.53.03.5-1.5-1.8-1.9-1.8-1.8-1.8-1.8-1.8-1.7-1.6
Intermittent access standard deviation0.51.11.50.81.01.01.11.01.01.11.01.21.2
Left kidney weight0.73.56.92.62.21.61.91.62.11.91.61.41.3
Right kidney weight0.42.06.52.51.70.91.31.01.51.41.11.00.9
Cocaine induced anxiety0.10.20.3-0.60.00.60.20.40.50.30.60.50.4
Post-drug Anxiety0.10.10.4-0.7-0.4-0.2-0.4-0.2-0.1-0.3-0.2-0.2-0.2
Baseline Anxiety0.40.40.80.2-0.3-0.9-0.6-0.7-0.7-0.5-0.9-0.7-0.8
Tail length2.28.510.43.22.92.92.93.02.72.82.62.93.1
Length with tail0.52.15.12.31.31.21.31.31.11.31.21.61.6
Length without tail0.41.21.6-0.0-1.1-1.3-1.1-1.3-1.2-1.2-1.1-0.9-1.0
Times rat made contact with spout0.00.00.1-0.20.20.20.10.20.30.2-0.0-0.2-0.2
Lifetime Intake0.80.91.3-1.1-1.1-1.0-1.1-1.0-1.1-1.0-0.9-0.7-0.6
Liver weight, left0.30.62.11.40.50.50.60.50.20.50.71.01.0
Liver weight, right1.22.03.31.81.31.21.31.21.01.31.41.71.7
Locomotor activity1.01.62.2-0.3-1.1-1.4-1.3-1.3-1.2-1.2-1.4-1.4-1.5
Locomotor testing distance1.11.92.7-0.3-1.2-1.5-1.4-1.4-1.3-1.4-1.5-1.6-1.6
Locomotor testing rearing0.20.42.41.60.80.20.40.20.90.40.0-0.3-0.3
Locomotion in novel chamber0.70.81.6-0.4-0.6-1.0-0.8-1.0-0.6-0.9-1.1-1.3-1.3
Locomotion in novel chamber post-restriction0.40.61.10.70.50.80.80.80.50.60.81.10.9
Fecal boli incidents, locomotor time 10.81.22.31.50.80.91.10.90.80.91.11.41.3
Change in fecal boli incidents, locomotor task2.02.02.80.51.61.71.51.61.61.61.31.01.2
Time >=10cm from walls, locomotor time 10.00.00.20.00.20.1-0.10.20.20.2-0.3-0.4-0.2
Bouts of movement, locomotor time 10.10.10.6-0.7-0.20.30.30.20.20.10.40.40.4
Total resting periods, locomotor time 10.20.21.1-1.1-0.10.40.30.30.20.20.50.50.5
Rest time, locomotor task time 10.10.11.0-1.0-0.4-0.0-0.0-0.1-0.0-0.10.20.40.3
Distance moved, locomotor task time 10.61.01.80.2-0.6-1.0-1.0-0.9-0.8-0.9-1.1-1.3-1.4
Vertical activity count, locomotor time 10.30.74.62.20.4-0.1-0.2-0.10.0-0.1-0.7-1.0-0.9
Time >=10cm from walls, locomotor time 21.31.92.8-1.1-1.7-1.2-1.5-1.3-1.5-1.6-1.5-1.1-1.0
Bouts of movement, locomotor time 20.10.10.7-0.8-0.00.10.10.1-0.00.00.1-0.2-0.4
Total resting periods, locomotor time 20.00.10.3-0.60.00.10.10.1-0.00.00.1-0.2-0.4
Rest time, locomotor task time 20.10.10.40.30.30.40.40.30.60.30.40.30.1
Distance moved, locomotor task time 22.83.33.8-1.4-1.9-1.9-1.9-1.9-1.9-1.9-1.8-1.7-1.6
Vertical activity count, locomotor time 20.40.61.31.2-0.3-0.6-0.6-0.6-0.3-0.6-0.9-1.0-0.9
Light reinforcement 13.79.027.95.33.42.62.72.62.92.72.22.32.2
Light reinforcement 22.43.616.44.01.91.51.61.51.31.51.11.41.4
Bone: marrow area0.10.11.21.10.2-0.1-0.0-0.20.1-0.0-0.2-0.2-0.2
Bone: maximum diameter0.40.71.40.50.70.50.90.60.80.91.11.21.1
Bone: maximum force0.20.30.50.2-0.6-0.7-0.5-0.6-0.7-0.6-0.5-0.3-0.4
Bone: maximum moment0.10.20.40.1-0.5-0.6-0.4-0.6-0.6-0.5-0.4-0.2-0.3
Mean time between licks in bursts0.40.91.70.71.20.91.00.91.31.11.00.60.7
Mean num. licks in bursts0.10.20.9-1.0-0.6-0.0-0.3-0.1-0.5-0.4-0.2-0.0-0.0
Cd content in liver0.60.71.4-1.2-0.6-1.1-0.9-1.0-0.3-0.6-0.7-0.8-0.7
Co content in liver0.30.32.2-1.5-0.5-0.4-0.2-0.3-0.2-0.20.20.20.1
Cu content in liver0.10.10.3-0.2-0.2-0.6-0.2-0.5-0.3-0.3-0.3-0.2-0.2
Fe content in liver0.91.02.60.10.31.21.01.10.20.71.21.61.6
K content in liver0.60.60.9-0.8-0.9-0.8-0.7-0.8-0.9-0.9-0.6-0.5-0.5
Mg content in liver0.10.10.2-0.3-0.4-0.2-0.0-0.1-0.4-0.20.10.40.3
Mn content in liver0.40.40.90.90.80.30.60.50.80.70.60.60.5
Na content in liver0.00.10.20.1-0.3-0.0-0.2-0.1-0.4-0.3-0.20.10.0
Rb content in liver0.50.60.80.90.90.70.80.70.80.80.80.70.6
Se content in liver1.21.54.10.70.41.01.21.00.20.81.32.02.0
Sr content in liver0.40.30.5-0.5-0.6-0.7-0.6-0.7-0.6-0.5-0.5-0.4-0.3
Zn content in liver0.80.91.2-1.0-1.0-1.1-0.9-1.1-0.9-1.0-0.9-0.9-0.9
Bone: minimum diameter0.50.92.91.71.00.70.90.80.90.90.70.80.8
Time in familiar zone, hab. session 11.41.42.50.91.51.11.21.11.61.31.20.80.8
Time in novel zone, hab. session 12.02.02.8-1.4-1.7-1.2-1.5-1.2-1.6-1.5-1.4-1.4-1.3
Total zone transitions, hab. session 10.10.10.30.5-0.1-0.2-0.3-0.2-0.2-0.3-0.4-0.6-0.5
Total locomotion distance, hab. session 10.10.20.40.2-0.4-0.4-0.4-0.4-0.4-0.5-0.5-0.6-0.6
Locomotion velocity, hab. session 10.10.10.30.6-0.2-0.3-0.3-0.3-0.2-0.3-0.4-0.4-0.5
Time in familiar zone, hab. session 21.61.72.71.51.61.21.31.21.21.51.11.01.1
Time in novel zone, hab. session 24.04.14.8-1.8-2.2-2.1-2.2-2.1-1.8-2.1-2.0-2.0-2.1
Total zone transitions, hab. session 20.91.22.01.11.41.01.11.11.31.30.90.70.7
Total locomotion distance, hab. session 20.10.10.90.90.3-0.00.1-0.00.20.10.0-0.1-0.1
Locomotion velocity, hab. session 20.10.10.80.90.2-0.10.1-0.10.00.0-0.1-0.1-0.1
Novel to familiar place preference ratio0.80.81.4-1.0-0.8-0.8-0.9-0.8-0.6-0.8-1.0-1.2-1.2
Novelty place preference1.11.22.0-1.0-0.9-1.0-1.1-1.0-0.8-1.0-1.3-1.4-1.4
Time in novel zone, NPP test1.41.52.2-1.2-1.1-1.0-1.2-1.1-1.0-1.2-1.3-1.5-1.4
Total zone transitions, NPP test0.50.81.91.40.90.60.90.61.00.80.80.70.7
Total locomotion distance, NPP test0.10.10.20.40.40.20.30.10.40.30.30.10.0
Locomotion velocity, NPP test0.10.10.40.60.50.10.40.10.40.40.40.30.2
Intraocular pressure0.81.13.1-1.8-1.1-0.9-1.0-1.0-0.8-1.0-0.8-0.9-0.8
Delta distance traveled before/after self-admin0.00.00.10.20.20.20.20.20.30.20.10.00.0
Delta ambulatory time before/after self-admin0.60.81.10.81.00.91.00.91.10.90.80.70.7
Parametrial fat weight0.10.21.91.40.3-0.20.1-0.2-0.20.10.00.20.1
Pavlov. Cond. lever latency0.20.30.80.50.0-0.4-0.4-0.40.1-0.3-0.6-0.9-0.8
Pavlov. Cond. magazine entry latency0.10.21.1-1.1-0.40.1-0.10.1-0.4-0.10.10.30.2
Pavlov. Cond. change in total contacts1.21.22.40.20.71.21.21.20.81.01.31.61.4
Pavlov. Cond. index score0.20.20.9-0.9-0.20.30.20.3-0.20.20.50.70.6
Pavlov. Cond. latency score0.20.20.5-0.7-0.10.30.30.3-0.10.30.50.70.6
Pavlov. Cond. lever contacts0.20.20.8-0.9-0.40.20.10.2-0.40.00.30.60.5
Pavlov. Cond. magazine entry number0.30.42.41.50.90.20.30.20.80.50.1-0.2-0.1
Pavlov. Cond. intertrial magazine entries1.21.53.00.91.00.91.21.00.91.11.41.71.7
Pavlov. Cond. lever-magazine prob. diff.0.20.31.8-1.3-0.6-0.1-0.1-0.1-0.6-0.20.20.40.4
Pavlov. Cond. response bias0.20.31.7-1.3-0.50.30.10.3-0.4-0.00.40.60.5
Pavlov. Cond. lever latency0.20.30.4-0.4-0.6-0.5-0.5-0.6-0.5-0.5-0.5-0.4-0.4
Pavlov. Cond. magazine entry latency0.10.20.4-0.00.60.20.30.40.30.70.40.40.4
Pavlov. Cond. change in total contacts0.40.70.90.20.90.80.80.90.71.00.90.80.9
Pavlov. Cond. index score0.20.30.40.20.60.60.50.60.50.70.60.50.5
Pavlov. Cond. latency score0.30.40.50.20.70.60.60.70.50.70.70.60.7
Pavlov. Cond. lever contacts0.20.30.50.50.70.50.50.60.60.60.40.30.3
Pavlov. Cond. magazine entry number0.10.10.1-0.2-0.3-0.1-0.2-0.2-0.1-0.3-0.3-0.3-0.3
Pavlov. Cond. intertrial magazine entries1.21.83.92.01.41.31.41.21.61.21.21.01.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.10.60.50.50.60.40.60.50.50.5
Pavlov. Cond. response bias0.00.10.20.20.40.20.20.30.20.30.20.10.2
Time in closed arm before self-admin1.62.02.50.71.31.61.51.51.41.41.61.51.6
Time in closed arm after self-admin1.01.11.60.20.91.11.21.11.11.01.21.11.1
Time in open arm before self-admin0.30.31.1-1.0-0.4-0.5-0.5-0.5-0.5-0.4-0.5-0.4-0.5
Time in open arm after self-admin0.91.01.3-0.2-0.9-1.0-1.0-1.0-1.0-1.0-1.1-1.1-1.1
Bone: periosteal estimation0.10.31.71.30.60.20.40.20.60.50.30.30.2
Bone: periosteal perimeter1.01.82.31.51.40.81.31.01.41.41.41.41.4
Bone: post-yield work0.10.20.30.5-0.3-0.2-0.4-0.3-0.3-0.4-0.5-0.5-0.5
Progressive ratio test 1 active lever presses1.41.72.1-1.3-1.4-1.4-1.4-1.3-1.5-1.4-1.3-1.1-1.0
Progressive ratio test 1 breakpoint1.61.92.3-1.4-1.5-1.4-1.5-1.4-1.5-1.4-1.4-1.2-1.1
Progressive ratio test 1 inactive lever presses0.40.61.0-0.8-1.0-0.7-0.7-0.8-1.0-0.8-0.7-0.5-0.4
Progressive ratio test 2 active lever presses1.41.62.0-1.3-1.4-1.3-1.4-1.3-1.4-1.3-1.2-1.1-1.0
Progressive ratio test 2 breakpoint1.61.82.2-1.4-1.4-1.4-1.5-1.4-1.4-1.4-1.3-1.2-1.1
Progressive ratio test 2 inactive lever presses1.42.23.2-1.8-1.6-1.5-1.5-1.5-1.6-1.5-1.4-1.3-1.2
Incentive Sensitization - Responses0.20.30.4-0.5-0.6-0.6-0.6-0.6-0.5-0.6-0.5-0.5-0.4
Incentive Sensitization - Breakpoint0.20.20.3-0.4-0.5-0.5-0.6-0.5-0.4-0.5-0.5-0.4-0.4
Sum of active levers in priming session hrs 5-60.10.10.30.2-0.0-0.4-0.2-0.3-0.3-0.2-0.5-0.5-0.6
Progressive ratio0.10.11.11.00.2-0.1-0.2-0.10.3-0.1-0.2-0.3-0.3
Food seeking constrained by brief footshock1.72.14.02.01.31.41.31.31.61.21.41.51.4
Seeking ratio, punishment vs. effort0.40.61.10.70.50.70.80.80.50.70.81.11.1
Retroperitoneal fat weight0.00.21.51.20.1-0.30.1-0.3-0.1-0.00.10.20.1
Reaction time number correct0.10.21.4-1.2-0.20.20.30.20.10.10.50.40.4
Reaction time mean minus median0.61.52.3-1.1-1.3-1.4-1.3-1.2-1.5-1.2-1.2-1.1-0.9
Reaction time mean minus median AUC0.82.02.9-1.6-1.5-1.6-1.5-1.4-1.7-1.3-1.3-1.1-1.0
Reaction time num false alarms0.50.71.2-1.1-0.7-1.0-0.7-1.0-0.5-0.7-0.7-0.9-0.9
Reaction time num false alarms AUC0.20.31.4-1.2-0.4-0.5-0.3-0.6-0.1-0.4-0.2-0.5-0.5
Reaction time trials correct on left0.10.21.4-1.2-0.20.20.30.20.10.10.50.40.4
Reaction time trials on left0.10.21.6-1.3-0.30.10.20.0-0.0-0.10.30.30.3
Reaction time mean3.04.86.5-2.5-2.3-2.3-2.2-2.2-2.3-2.1-2.0-1.9-1.8
Reaction time mean AUC2.64.26.2-2.5-2.1-2.2-2.1-2.1-2.2-1.9-1.9-1.8-1.7
Median of all reaction times3.04.26.6-2.6-2.2-2.1-2.1-2.1-2.1-2.0-1.9-1.8-1.7
Reaction time omissions2.63.84.9-1.6-2.0-2.2-1.9-2.2-1.9-2.0-1.9-1.8-1.8
Reaction time false alarm rate0.10.10.2-0.4-0.2-0.4-0.3-0.4-0.1-0.2-0.3-0.5-0.4
Reaction time premature initiation rate4.46.18.83.02.72.42.42.42.52.42.32.32.2
Reaction time premature initiations2.64.65.32.02.32.22.22.22.22.12.22.12.0
Std. dev. reaction times1.42.53.3-1.6-1.7-1.7-1.7-1.6-1.8-1.5-1.5-1.4-1.3
Reaction time trials completed0.10.21.6-1.3-0.30.10.20.0-0.0-0.10.30.30.3
Reaction time trials AUC0.10.21.8-1.4-0.4-0.10.0-0.1-0.2-0.20.20.10.1
Run reversals in cocaine runway, females4.44.45.5-0.9-2.1-2.4-2.2-2.3-2.2-2.3-2.2-2.0-2.0
Run reversals in cocaine runway, males0.60.61.7-1.3-0.7-0.7-0.7-0.7-0.6-0.6-0.7-0.8-0.8
Latency to leave start box in cocaine runway2.12.43.2-0.6-1.4-1.7-1.7-1.7-1.6-1.5-1.8-1.6-1.5
Latency to leave start box in cocaine runway, F2.52.93.5-1.0-1.8-1.8-1.9-1.8-1.9-1.8-1.8-1.6-1.6
Latency to leave start box in cocaine runway, M0.10.10.30.60.2-0.3-0.2-0.20.10.0-0.4-0.4-0.2
Std. dev. time between licks in bursts1.01.42.81.41.51.01.21.11.71.21.10.70.7
Total sessions with >9 infusions0.40.52.4-1.6-0.8-0.4-0.6-0.4-0.7-0.5-0.2-0.1-0.1
Short access day 1 total inactive lever presses0.81.11.6-0.2-1.3-1.1-1.2-1.2-1.2-1.3-1.1-0.7-0.7
Short access day 10 total inactive lever presses1.12.83.11.51.61.81.71.71.61.61.71.71.7
Short access day 1 total infusions0.60.82.8-1.7-1.2-0.6-0.9-0.7-0.9-0.8-0.3-0.2-0.3
Short access day 10 total infusions0.40.41.1-1.1-0.8-0.6-0.7-0.6-0.8-0.6-0.5-0.3-0.2
Short access total infusions0.60.81.7-1.3-1.1-0.9-1.0-0.9-1.0-0.9-0.7-0.5-0.5
Short access day 1 locomotion1.11.43.9-2.0-1.5-1.0-1.3-1.1-1.2-1.1-0.8-0.6-0.7
Short access day 10 total locomotion0.10.21.5-1.2-0.2-0.2-0.1-0.2-0.1-0.1-0.1-0.2-0.2
Short access total locomotion0.70.83.1-1.7-1.0-0.8-0.8-0.8-0.9-0.7-0.5-0.5-0.6
One hour access (0.3 mA shock)0.81.01.1-1.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.9
Compulsive drug intake1.31.52.10.11.21.31.41.41.21.41.41.21.2
One hour access (shock baseline)1.42.22.6-1.0-1.5-1.6-1.6-1.6-1.4-1.5-1.6-1.5-1.3
Social response proportion1.01.21.8-0.3-0.9-1.4-1.1-1.3-1.1-1.0-1.1-1.1-1.1
Social responses0.10.20.50.40.5-0.30.0-0.20.40.2-0.2-0.7-0.7
Social time1.11.52.00.71.41.31.31.31.31.41.21.11.1
Soleus weight0.00.10.4-0.2-0.0-0.4-0.3-0.3-0.1-0.2-0.4-0.6-0.6
Bone: stiffness0.81.31.70.4-1.1-1.2-1.2-1.2-1.3-1.3-1.3-1.0-1.1
Tibialis anterior weight0.00.00.3-0.6-0.0-0.2-0.1-0.1-0.00.10.10.0-0.0
Time to tail flick, vehicle, before self-admin0.10.10.60.70.30.20.20.20.40.20.10.0-0.1
Time to tail flick, vehicle, after self-admin0.20.20.70.90.1-0.2-0.1-0.30.1-0.2-0.5-0.7-0.7
Time to tail flick, test, before self-admin3.94.15.2-1.7-2.2-2.1-2.2-2.1-2.3-2.1-1.9-1.7-1.8
Time to tail flick, test, after self-admin0.10.10.20.2-0.0-0.2-0.1-0.2-0.2-0.1-0.2-0.3-0.5
Delta time to tail flick, vehicle, before/after SA0.00.00.10.2-0.2-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.2
Delta time to tail flick, test, before/after SA0.70.71.00.41.00.81.00.91.01.00.90.60.5
Tibia length0.00.10.30.1-0.40.1-0.00.1-0.5-0.30.00.50.4
Ambulatory time before self-admin1.11.62.4-1.6-1.5-1.2-1.4-1.2-1.4-1.3-1.1-0.9-1.0
Ambulatory time after self-admin0.30.30.5-0.7-0.7-0.5-0.7-0.6-0.6-0.6-0.5-0.5-0.5
Bone: tissue strength0.30.30.6-0.8-0.7-0.6-0.4-0.6-0.7-0.5-0.10.10.0
Total heroin consumption0.20.30.6-0.2-0.3-0.6-0.4-0.6-0.4-0.5-0.6-0.8-0.7
Bone: trabecular number3.86.39.32.12.53.12.62.92.42.52.32.32.3
Bone: trabecular spacing2.83.85.1-1.8-2.0-2.3-2.0-2.2-1.8-1.9-1.8-1.8-1.8
Bone: trabecular thickness0.10.20.70.80.30.60.40.50.20.30.20.20.2
Bone: trabecular tissue density4.46.57.2-1.8-2.6-2.6-2.6-2.6-2.7-2.7-2.6-2.5-2.6
Water consumed over 24 hours0.10.20.60.80.60.40.30.50.50.40.1-0.1-0.1
Number of responses in last shaping day0.30.40.6-0.80.20.60.50.60.30.50.80.70.7