Hub : Genes

Erbb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Erbb3	0.16	0.08	1.4e-14	0.13	0.13	0.12	0.13	2.2e-12	6.1e-12	1.3e-11	5.9e-12
2	Liver	mRNA stability	Erbb3	0.03	0.02	5.6e-03	0.02	0.02	0.02	0.02	1.3e-03	4.3e-03	1.6e-03	1.3e-03
3	BLA	gene expression	Erbb3	0.11	0.07	7.4e-07	0.14	0.13	0.13	0.14	8.2e-08	1.6e-07	2.2e-07	1.1e-07
4	NAcc	gene expression	Erbb3	0.06	0.04	2.0e-06	0.04	0.04	0.05	0.04	1.8e-05	5.2e-06	2.9e-06	6.2e-06
5	PL	gene expression	Erbb3	0.06	0.04	1.4e-06	0.02	0.05	0.04	0.04	1.8e-03	1.6e-06	1.2e-05	1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.2	2.1	4.7	-0.9	-0.8	-0.8	-1.8	2.2
Area under the delay curve	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.3	0.2
BMI with tail	6.0	19.5	27.4	4.6	-5.2	4.8	3.9	-3.2
BMI without tail	1.5	3.2	4.0	2.0	-1.6	1.9	1.8	-1.6
Body weight	1.1	4.8	6.6	2.3	-2.4	2.6	1.9	-1.7
Weight adjusted by age	0.1	0.2	0.3	0.1	0.2	0.4	0.5	-0.6
Bone surface	3.2	5.6	12.0	-1.7	-0.9	-2.0	-2.9	3.5
Bone volume	3.0	5.1	11.1	-1.6	-1.1	-1.7	-2.8	3.3
Breakpoint value in progressive ratio session	1.2	1.3	2.9	-1.2	1.7	-1.2	-0.7	0.5
Number of licking bursts	3.9	4.6	5.6	2.3	-1.7	2.4	2.2	-2.1
Context. condit. distance diff. score	0.2	0.2	0.3	0.5	-0.5	0.4	0.5	-0.5
Locomotion velocity, session 1	0.4	0.4	0.9	-0.2	-0.5	-0.2	-0.9	0.9
Locomotion distance, session 1	1.1	1.4	2.7	-1.0	-0.1	-1.0	-1.5	1.7
Locomotion velocity, session 2	2.9	3.4	5.2	-1.8	0.5	-1.9	-2.1	2.3
Locomotion distance, session 2	3.9	5.4	7.5	-2.5	1.4	-2.1	-2.7	2.6
Locomotion velocity, session 3	3.7	4.3	6.3	-2.2	2.5	-2.2	-1.8	1.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	0.4	-0.1	-0.0	-0.1
Stereotopy head waving bouts, day 3	5.3	6.3	7.7	-2.6	2.5	-2.8	-2.4	2.2
Stereotopy head waving duration, day 3	3.7	4.4	6.4	-2.2	1.9	-2.5	-1.9	1.8
Locomotion velocity, session 7	0.3	0.3	0.4	-0.5	0.1	-0.6	-0.6	0.6
Locomotion distance, session 7	0.3	0.3	0.7	0.4	-0.1	0.5	0.8	-0.8
Stereotopy head waving bouts, day 7	1.5	1.7	2.7	-1.1	0.7	-1.3	-1.6	1.6
Stereotopy head waving duration, day 7	1.5	1.8	3.2	-1.1	0.6	-1.2	-1.8	1.7
Locomotion velocity, session 8	2.7	3.2	5.1	-1.8	0.8	-1.5	-2.2	2.2
Locomotion distance, session 8	0.4	0.7	0.9	-1.0	0.6	-0.7	-0.9	0.8
Degree of sensitization distance	0.4	0.4	0.7	0.6	-0.8	0.6	0.5	-0.4
Degree of sensitization stereotypy	0.2	0.2	0.3	0.1	-0.4	0.0	-0.6	0.6
Conditioned locomotion	2.0	2.3	3.5	1.6	-0.5	1.6	1.8	-1.9
Cocaine response after cond. corrected	3.2	3.6	4.8	1.9	-1.2	1.9	2.2	-2.1
Cocaine response after cond. not corrected	3.6	4.0	5.2	2.1	-1.1	2.0	2.3	-2.2
Cocaine response before conditioning	0.5	0.6	0.8	-0.7	0.7	-0.8	-0.9	0.8
Saline control response	0.5	0.7	0.9	0.9	-0.6	0.9	0.8	-0.8
Bone: connectivity density	0.8	1.2	2.8	-0.7	-0.6	-0.7	-1.4	1.7
Bone: cortical apparent density	1.2	1.6	2.4	1.3	-1.6	1.2	1.2	-0.9
Bone: cortical area	0.5	0.8	3.2	0.5	-1.8	0.2	-0.3	0.7
Bone: cortical porosity	0.3	0.3	0.6	-0.4	-0.3	-0.6	-0.5	0.7
Bone: cortical porosity	0.3	0.4	0.7	-0.1	-0.8	-0.4	-0.5	0.8
Bone: cortical thickness	0.8	1.3	3.6	1.2	-1.9	0.9	0.6	-0.2
Bone: cortical thickness	1.0	1.1	1.4	1.2	-0.9	1.0	1.1	-1.1
Bone: cortical tissue density	0.9	1.2	1.7	1.1	-1.3	1.1	1.1	-0.8
Condit. Reinf. active minus inactive responses	1.9	2.1	2.9	-1.7	1.4	-1.7	-1.3	1.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.4	0.6	-0.4	0.0	-0.0
Condit. Reinf. active responses	3.5	4.3	5.5	-2.3	1.5	-2.3	-2.1	2.0
Condit. Reinf. inactive responses	2.4	2.9	3.7	-1.8	1.0	-1.7	-1.9	1.9
Incentive salience index mean	1.8	2.2	2.9	-1.7	0.9	-1.6	-1.6	1.5
Condit. Reinf. lever presses	1.4	1.8	3.3	-1.3	0.0	-1.0	-1.8	1.8
Condit. Reinf. active minus inactive responses	1.0	1.3	3.5	-1.1	1.9	-1.3	-0.5	0.2
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.5	-0.0	1.2	-0.1	0.6	-0.9
Condit. Reinf. active responses	1.0	1.4	2.1	-1.2	1.4	-1.4	-0.9	0.8
Condit. Reinf. inactive responses	0.6	0.7	1.1	-0.8	0.4	-0.9	-1.0	1.0
Condit. Reinf. lever presses	1.5	2.0	4.8	-1.5	2.2	-1.4	-0.9	0.6
Condit. Reinf. lever reinforcers received	0.6	0.9	1.8	-0.9	1.3	-1.1	-0.6	0.4
Conditioned reinforcement - actives	0.4	0.4	0.7	-0.4	-0.3	-0.8	-0.5	0.9
Conditioned reinforcement - inactives	1.6	1.8	3.0	1.4	-1.0	1.0	1.7	-1.4
Conditioned locomotion	2.8	3.3	6.2	-1.9	1.5	-2.5	-1.5	1.6
Patch foraging indifference point 0 sec	2.6	4.1	7.7	2.3	-2.8	2.0	1.6	-1.1
Patch foraging indifference point AUC	0.5	0.5	1.0	-0.9	1.0	-0.5	-0.6	0.4
Delay disc. indifference point, 0s delay	0.7	0.8	2.4	0.3	-1.6	0.8	-0.5	0.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	-0.7	0.5	-0.5	-0.5	0.4
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	-0.1	-0.6	0.4	-0.2	0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.4	-0.4	0.8	0.2	-0.3
Delay disc. indifference point, 4s delay	0.8	0.9	1.5	-0.9	0.3	-0.7	-1.2	1.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	0.4	-0.0	0.8	0.6	-0.8
Indifference point function ln k	0.2	0.2	0.5	0.6	-0.7	0.2	0.5	-0.3
Indifference point function log k	0.2	0.2	0.5	0.6	-0.7	0.2	0.5	-0.3
Patch foraging total patch changes 0 sec	2.5	4.0	7.0	2.2	-2.6	1.9	1.7	-1.2
Patch foraging total patch changes 12 sec	2.1	2.7	3.5	1.8	-1.3	1.9	1.7	-1.5
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	-0.1
Patch foraging total patch changes 24 sec	0.3	0.4	0.7	0.8	-0.8	0.8	0.3	-0.2
Patch foraging total patch changes 6 sec	1.3	1.9	3.2	1.5	-1.8	1.3	1.3	-0.9
Patch foraging time to switch 0 sec	0.1	0.2	0.5	0.2	-0.7	0.4	-0.2	0.3
Patch foraging water rate 0 sec	0.9	1.4	2.2	1.2	-0.6	1.1	1.5	-1.4
Patch foraging water rate 12 sec	1.4	2.1	2.9	1.7	-0.8	1.3	1.7	-1.6
Patch foraging water rate 18 sec	1.2	1.7	3.5	1.0	0.6	0.8	1.7	-1.9
Patch foraging water rate 24 sec	4.0	5.5	9.0	2.2	-0.4	2.3	2.9	-3.0
Patch foraging water rate 6 sec	0.3	0.5	1.0	0.1	1.0	-0.4	0.7	-0.9
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.9	-1.4	0.9	-1.7	-1.4	1.5
Distance traveled before self-admin	1.0	1.0	1.4	-1.2	1.0	-1.0	-1.0	0.8
Distance traveled after self-admin	0.2	0.3	0.4	-0.3	0.4	-0.6	-0.6	0.6
Extensor digitorum longus weight	5.7	22.3	27.2	5.1	-4.3	5.2	4.7	-4.2
Bone: elastic displacement	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1	0.2
Bone: elastic work	0.3	0.4	1.3	0.6	-1.1	0.5	0.1	0.1
Bone: endosteal estimation	0.3	0.7	2.5	0.7	-1.6	0.4	0.3	0.2
Bone: endosteal perimeter	0.7	1.4	2.3	-1.1	0.1	-1.3	-1.3	1.5
Epididymis fat weight	0.0	0.1	0.3	-0.3	0.5	-0.2	-0.0	-0.2
Delta time in closed arm before/after self-admin	3.0	2.9	5.0	1.5	-0.3	1.6	2.2	-2.2
Delta time in open arm before/after self-admin	0.9	0.9	1.4	1.2	-1.2	1.1	0.5	-0.5
Diff in mean of infusions in LGA sessions	1.4	1.6	2.6	-1.2	1.6	-1.4	-1.0	0.8
Delay discount exponential model param	0.0	0.0	0.1	0.2	0.1	-0.2	0.3	-0.2
Extinction: sum of active levers before priming	1.5	1.5	5.0	-1.1	2.2	-1.0	-0.5	-0.0
Active lever presses in extinction session 6	1.3	1.3	1.8	-1.4	1.1	-1.0	-1.2	0.9
Bone: final force	1.3	2.2	6.5	1.5	-2.5	1.4	0.5	-0.1
Bone: final moment	1.3	2.1	6.3	1.4	-2.5	1.3	0.5	-0.1
Food consumed during 24 hour testing period	0.4	0.4	0.7	0.8	-0.7	0.7	0.5	-0.4
Glucose	1.7	2.5	3.2	1.8	-1.7	1.8	1.4	-1.2
Heart weight	0.1	0.1	0.4	0.2	-0.3	0.1	0.6	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.1	0.1	0.3	-0.4	0.2	-0.1
Intermittent access intake day 1-15 change	0.1	0.1	0.4	-0.3	0.4	-0.7	0.1	0.1
Intermittent access intake escalation	0.4	0.4	0.8	0.3	0.5	0.0	0.9	-0.9
Intermittent access intake escalation 2	0.3	0.3	1.0	-0.3	1.0	-0.3	0.4	-0.5
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.9	0.5	0.5	0.1	0.9	-0.9
Intermitt. access day 15 inactive lever presses	0.3	0.4	1.3	-0.4	1.2	-0.5	0.1	-0.2
Intermitt. access escalation Index	1.1	1.0	1.7	-0.7	-0.4	-1.2	-1.0	1.3
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.5	-0.8	0.3	0.2	-0.0
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.6	-0.4	0.2	0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.6	0.3	-0.8	-0.2	0.1	0.2
Intermittent access total infusions	0.3	0.4	0.6	0.8	-0.8	0.4	0.6	-0.4
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.2	0.0	0.0	0.1	-0.1
Intermittent access day 15 total locomotion	0.2	0.3	0.8	-0.4	0.5	-0.9	-0.1	0.3
Intermittent access total locomotion	0.2	0.2	0.4	-0.4	0.4	-0.6	-0.4	0.5
Intermittent access standard deviation	0.1	0.1	0.3	-0.2	0.3	-0.5	0.2	-0.1
Left kidney weight	0.2	0.6	1.2	-0.4	-0.9	-0.4	-0.8	1.1
Right kidney weight	0.4	1.2	1.9	-1.1	0.4	-1.4	-1.1	1.2
Cocaine induced anxiety	2.3	2.7	3.5	-1.7	1.1	-1.6	-1.9	1.8
Post-drug Anxiety	1.6	1.7	3.3	-1.1	0.1	-1.1	-1.7	1.8
Baseline Anxiety	0.1	0.1	0.2	0.3	-0.0	0.3	0.4	-0.4
Tail length	2.9	8.9	17.7	-3.0	4.2	-3.2	-2.3	1.6
Length with tail	1.2	4.5	6.0	-2.2	2.4	-2.2	-2.1	1.6
Length without tail	0.1	0.3	0.7	-0.2	-0.8	0.1	-0.5	0.6
Times rat made contact with spout	1.4	1.6	1.9	1.4	-0.9	1.4	1.4	-1.3
Lifetime Intake	0.7	0.8	2.0	1.0	-1.4	0.6	0.6	-0.2
Liver weight, left	1.6	2.5	3.1	1.8	-1.6	1.4	1.8	-1.4
Liver weight, right	0.7	1.1	1.9	1.3	-1.4	1.0	0.9	-0.6
Locomotor activity	3.6	5.7	7.0	-2.5	2.0	-2.6	-2.5	2.2
Locomotor testing distance	1.4	2.3	3.3	-1.6	1.2	-1.8	-1.5	1.4
Locomotor testing rearing	0.0	0.1	0.2	0.2	0.2	0.1	0.3	-0.4
Locomotion in novel chamber	0.2	0.2	0.4	0.5	-0.6	0.4	0.5	-0.3
Locomotion in novel chamber post-restriction	2.7	3.2	4.2	-2.1	2.0	-1.9	-1.6	1.3
Fecal boli incidents, locomotor time 1	1.4	1.5	2.2	1.3	-0.4	1.3	1.3	-1.5
Change in fecal boli incidents, locomotor task	1.6	1.5	2.4	-1.3	0.3	-1.1	-1.5	1.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.1	0.4	-1.1	0.3	-0.2	0.4
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.7	0.7	-0.5	-0.4	0.3
Total resting periods, locomotor time 1	0.8	0.9	1.3	-1.1	1.1	-1.0	-0.8	0.7
Rest time, locomotor task time 1	0.4	0.5	0.7	-0.7	0.6	-0.5	-0.8	0.7
Distance moved, locomotor task time 1	0.3	0.3	1.3	0.4	-1.1	0.1	-0.1	0.5
Vertical activity count, locomotor time 1	0.9	1.0	1.3	1.1	-1.2	0.7	1.1	-0.8
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.6	1.3	-1.0	1.2	1.3	-1.1
Bouts of movement, locomotor time 2	0.8	0.8	1.4	-0.9	0.2	-0.8	-1.1	1.2
Total resting periods, locomotor time 2	0.9	0.9	1.7	-0.9	0.1	-0.8	-1.2	1.3
Rest time, locomotor task time 2	0.3	0.3	0.7	-0.3	-0.0	-0.4	-0.8	0.8
Distance moved, locomotor task time 2	0.3	0.4	0.7	0.6	0.0	0.3	0.8	-0.9
Vertical activity count, locomotor time 2	2.2	2.4	3.3	1.6	-0.9	1.4	1.8	-1.8
Light reinforcement 1	3.0	5.5	7.4	-2.5	2.4	-2.7	-2.2	1.9
Light reinforcement 2	0.8	1.1	1.4	-1.1	1.1	-1.2	-1.0	0.8
Bone: marrow area	0.3	0.6	2.2	0.6	-1.5	0.4	0.3	0.2
Bone: maximum diameter	1.1	2.0	3.6	-1.3	-0.0	-1.5	-1.6	1.9
Bone: maximum force	1.5	2.7	7.3	1.7	-2.7	1.6	0.8	-0.3
Bone: maximum moment	1.5	2.6	7.2	1.7	-2.7	1.5	0.7	-0.3
Mean time between licks in bursts	0.5	0.6	1.3	-0.9	1.2	-1.0	-0.2	0.3
Mean num. licks in bursts	0.8	0.9	1.2	-1.0	0.9	-1.1	-1.0	0.9
Cd content in liver	0.2	0.3	0.5	0.1	-0.7	0.7	0.4	-0.3
Co content in liver	0.6	0.8	1.9	-1.1	1.4	-0.8	-0.4	0.2
Cu content in liver	0.5	0.6	2.4	0.5	-1.5	0.3	-0.0	0.5
Fe content in liver	0.7	0.8	1.1	0.9	-0.6	0.9	1.0	-0.9
K content in liver	1.0	1.0	1.6	-0.9	0.5	-0.9	-1.2	1.3
Mg content in liver	1.1	1.1	1.9	-1.0	0.3	-0.7	-1.3	1.4
Mn content in liver	2.6	3.0	6.2	-1.3	-0.1	-1.4	-2.2	2.5
Na content in liver	0.1	0.1	0.1	0.2	-0.3	0.3	-0.3	0.4
Rb content in liver	0.4	0.4	1.5	0.3	-1.2	0.0	-0.3	0.7
Se content in liver	0.1	0.1	0.2	-0.3	0.2	-0.2	-0.4	0.3
Sr content in liver	0.3	0.3	0.6	0.2	0.5	-0.1	0.7	-0.8
Zn content in liver	1.0	1.1	3.9	-0.8	2.0	-0.6	0.2	-0.7
Bone: minimum diameter	0.2	0.4	1.4	-0.0	-1.2	-0.2	-0.3	0.8
Time in familiar zone, hab. session 1	3.4	3.2	6.2	-2.0	2.5	-1.8	-1.3	0.9
Time in novel zone, hab. session 1	1.8	1.8	5.3	1.4	-2.3	1.2	0.5	-0.0
Total zone transitions, hab. session 1	1.1	1.6	2.7	-1.1	0.4	-1.0	-1.6	1.6
Total locomotion distance, hab. session 1	3.4	4.8	7.6	-2.1	0.9	-2.0	-2.7	2.8
Locomotion velocity, hab. session 1	3.0	4.2	6.0	-2.1	1.1	-1.9	-2.5	2.4
Time in familiar zone, hab. session 2	2.9	3.0	6.6	-1.8	2.6	-1.9	-1.0	0.6
Time in novel zone, hab. session 2	3.0	3.0	7.5	1.7	-2.7	1.9	0.9	-0.4
Total zone transitions, hab. session 2	0.5	0.6	1.4	0.1	-1.2	-0.0	-0.8	1.1
Total locomotion distance, hab. session 2	0.9	1.1	2.0	-1.0	0.3	-0.9	-1.4	1.4
Locomotion velocity, hab. session 2	1.2	1.6	2.9	-1.2	0.3	-1.0	-1.7	1.7
Novel to familiar place preference ratio	1.5	1.5	4.4	1.3	-2.1	1.2	0.2	0.2
Novelty place preference	1.0	1.0	3.0	0.9	-1.7	0.9	0.0	0.3
Time in novel zone, NPP test	1.3	1.3	3.9	1.2	-2.0	1.1	0.3	0.1
Total zone transitions, NPP test	0.2	0.3	0.6	0.4	-0.8	0.5	-0.3	0.4
Total locomotion distance, NPP test	0.3	0.4	0.9	-0.2	-0.5	-0.0	-0.8	0.9
Locomotion velocity, NPP test	0.4	0.5	1.2	-0.5	-0.1	-0.3	-1.0	1.1
Intraocular pressure	0.3	0.4	1.2	-0.2	1.1	0.1	0.5	-0.8
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.3	0.5
Parametrial fat weight	0.0	0.1	0.2	-0.3	0.4	0.1	0.1	-0.2
Pavlov. Cond. lever latency	0.6	0.7	1.4	0.8	0.1	0.6	1.1	-1.2
Pavlov. Cond. magazine entry latency	1.2	1.5	2.2	-1.5	1.5	-1.4	-0.9	0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.0	-0.6	0.1	0.2	-0.0
Pavlov. Cond. index score	0.8	1.1	1.5	-1.2	0.5	-1.0	-1.2	1.1
Pavlov. Cond. latency score	1.2	1.5	2.1	-1.4	0.4	-1.2	-1.4	1.4
Pavlov. Cond. lever contacts	0.7	0.8	1.7	-0.9	-0.3	-0.5	-1.2	1.3
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	1.1	-0.8	0.8	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.1	0.4	0.1	0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.7	-1.3	0.6	-1.1	-1.2	1.2
Pavlov. Cond. response bias	0.7	0.9	1.5	-1.2	0.9	-0.9	-0.9	0.7
Pavlov. Cond. lever latency	1.2	1.6	2.3	1.4	-1.5	1.2	1.2	-1.0
Pavlov. Cond. magazine entry latency	2.1	2.5	3.1	-1.8	1.7	-1.6	-1.4	1.3
Pavlov. Cond. change in total contacts	0.5	0.7	1.1	-0.9	1.0	-0.9	-0.6	0.6
Pavlov. Cond. index score	1.6	2.0	2.8	-1.6	1.7	-1.5	-1.2	1.0
Pavlov. Cond. latency score	1.9	2.3	2.9	-1.7	1.7	-1.6	-1.4	1.2
Pavlov. Cond. lever contacts	0.8	1.2	2.3	-1.2	1.5	-1.1	-0.8	0.6
Pavlov. Cond. magazine entry number	2.0	2.4	3.0	1.7	-1.6	1.7	1.4	-1.3
Pavlov. Cond. intertrial magazine entries	1.3	1.7	2.1	1.4	-0.9	1.4	1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	3.0	-1.7	1.7	-1.7	-1.3	1.2
Pavlov. Cond. response bias	1.4	1.9	3.5	-1.6	1.9	-1.5	-1.0	0.8
Time in closed arm before self-admin	0.3	0.3	0.7	-0.2	-0.7	-0.1	-0.6	0.8
Time in closed arm after self-admin	0.2	0.2	0.5	0.3	-0.7	0.3	0.5	-0.2
Time in open arm before self-admin	0.2	0.2	0.4	-0.4	0.6	-0.6	0.0	-0.0
Time in open arm after self-admin	1.3	1.4	2.2	1.5	-0.9	1.3	1.0	-1.1
Bone: periosteal estimation	0.5	1.1	4.5	0.6	-2.1	0.3	-0.1	0.7
Bone: periosteal perimeter	0.6	1.0	2.1	-0.7	-0.7	-0.8	-1.1	1.4
Bone: post-yield work	0.3	0.4	0.7	0.8	-0.9	0.6	0.5	-0.4
Progressive ratio test 1 active lever presses	1.3	1.4	2.1	1.5	-1.3	1.1	1.1	-0.8
Progressive ratio test 1 breakpoint	1.3	1.4	2.1	1.5	-1.4	1.1	1.0	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	-0.0	-0.4	-0.6	0.0	0.4
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	0.7	-1.0	0.4	0.6	-0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.6	0.1	-0.8	-0.2	-0.1	0.4
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.8	0.5	-0.9	0.0	0.1	0.2
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.2	0.3
Incentive Sensitization - Breakpoint	0.2	0.3	0.5	-0.5	0.2	-0.7	-0.4	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	0.6	-0.4	-0.3	0.2
Progressive ratio	1.2	1.4	1.9	1.4	-1.1	1.2	1.2	-1.0
Food seeking constrained by brief footshock	1.1	1.4	2.4	-1.4	1.5	-1.0	-1.1	0.7
Seeking ratio, punishment vs. effort	1.9	2.3	3.3	-1.8	1.8	-1.4	-1.4	1.0
Retroperitoneal fat weight	2.3	7.7	8.8	2.9	-2.9	3.0	2.7	-2.3
Reaction time number correct	1.7	2.4	3.1	1.8	-0.8	1.7	1.7	-1.6
Reaction time mean minus median	1.2	1.6	2.2	-1.5	1.3	-1.3	-1.2	1.0
Reaction time mean minus median AUC	2.5	3.3	4.6	-1.8	1.0	-1.8	-2.1	2.1
Reaction time num false alarms	0.7	0.9	1.4	1.1	-0.8	1.2	0.9	-0.9
Reaction time num false alarms AUC	1.0	1.4	2.0	1.3	-0.8	1.4	1.2	-1.2
Reaction time trials correct on left	1.7	2.4	3.1	1.8	-0.8	1.7	1.7	-1.6
Reaction time trials on left	1.5	2.2	2.9	1.7	-0.8	1.6	1.6	-1.6
Reaction time mean	1.6	2.3	3.2	-1.8	1.0	-1.4	-1.7	1.6
Reaction time mean AUC	1.0	1.3	1.8	-1.3	0.5	-1.0	-1.3	1.3
Median of all reaction times	1.0	1.4	2.0	-1.4	0.6	-1.0	-1.3	1.3
Reaction time omissions	0.1	0.1	0.2	-0.1	-0.1	-0.3	-0.3	0.5
Reaction time false alarm rate	0.1	0.1	0.2	0.3	-0.4	0.5	0.1	-0.1
Reaction time premature initiation rate	0.6	0.9	3.0	-0.6	1.7	-0.9	-0.2	-0.1
Reaction time premature initiations	0.5	0.7	1.7	0.3	1.3	-0.0	0.7	-1.0
Std. dev. reaction times	1.0	1.4	1.9	-1.4	0.9	-1.1	-1.3	1.3
Reaction time trials completed	1.5	2.2	2.9	1.7	-0.8	1.6	1.6	-1.6
Reaction time trials AUC	1.9	2.7	3.5	1.9	-0.8	1.8	1.8	-1.8
Run reversals in cocaine runway, females	2.2	2.1	2.5	-1.6	1.3	-1.5	-1.5	1.4
Run reversals in cocaine runway, males	2.9	2.8	3.8	-1.8	1.2	-2.0	-1.6	1.6
Latency to leave start box in cocaine runway	0.5	0.5	1.2	-0.4	-0.7	-0.1	-1.0	1.1
Latency to leave start box in cocaine runway, F	1.0	1.1	2.4	-0.6	-1.0	-0.3	-1.3	1.6
Latency to leave start box in cocaine runway, M	0.4	0.4	0.8	0.6	0.3	0.6	0.7	-0.9
Std. dev. time between licks in bursts	1.2	1.4	2.3	-1.0	0.3	-1.4	-1.2	1.5
Total sessions with >9 infusions	0.7	0.7	1.6	-0.1	-1.3	-0.7	-0.6	1.2
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.2	-0.3	-0.3	0.0	0.2
Short access day 10 total inactive lever presses	0.3	0.3	0.7	0.5	0.1	0.1	0.8	-0.7
Short access day 1 total infusions	0.8	0.9	3.1	0.5	-1.8	-0.3	-0.3	0.9
Short access day 10 total infusions	0.5	0.5	1.4	0.9	-1.2	0.3	0.6	-0.2
Short access total infusions	1.0	1.1	4.2	1.0	-2.0	0.4	0.2	0.4
Short access day 1 locomotion	0.4	0.4	0.8	-0.3	-0.2	-0.9	-0.6	0.9
Short access day 10 total locomotion	1.0	1.1	2.1	-1.0	1.4	-1.4	-0.4	0.4
Short access total locomotion	0.3	0.3	0.8	-0.3	0.2	-0.9	-0.5	0.7
One hour access (0.3 mA shock)	0.3	0.4	0.6	0.5	-0.8	0.6	0.6	-0.4
Compulsive drug intake	0.2	0.2	0.4	0.4	-0.5	0.6	0.2	-0.2
One hour access (shock baseline)	0.2	0.3	0.6	0.6	-0.2	0.2	0.8	-0.6
Social response proportion	1.0	1.1	1.5	-0.9	1.0	-1.0	-1.2	1.0
Social responses	8.9	11.4	13.2	-3.5	3.3	-3.6	-3.4	2.9
Social time	1.1	1.4	1.8	1.4	-1.0	1.2	1.1	-1.1
Soleus weight	5.3	15.6	20.2	4.5	-4.3	4.3	3.5	-3.0
Bone: stiffness	2.9	4.6	9.8	2.3	-3.1	2.2	1.4	-0.9
Tibialis anterior weight	1.0	3.6	4.5	2.1	-2.1	2.1	1.6	-1.4
Time to tail flick, vehicle, before self-admin	3.6	3.7	5.1	-2.1	0.5	-2.2	-1.9	2.3
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.7	-0.3	0.8	0.1	0.3	-0.6
Time to tail flick, test, before self-admin	2.2	2.2	3.0	-1.7	0.5	-1.5	-1.6	1.7
Time to tail flick, test, after self-admin	0.6	0.6	1.3	-0.7	-0.1	-0.7	-1.0	1.1
Delta time to tail flick, vehicle, before/after SA	2.9	2.8	4.6	1.5	-0.2	2.1	1.7	-2.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.4	0.6	0.3	0.4	-0.6
Tibia length	0.6	1.7	3.5	-1.5	1.9	-1.1	-1.1	0.7
Ambulatory time before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	0.4
Ambulatory time after self-admin	0.1	0.1	0.1	0.0	0.1	-0.3	-0.3	0.4
Bone: tissue strength	2.8	2.7	5.3	1.9	-2.3	1.6	1.2	-0.8
Total heroin consumption	2.2	2.6	3.0	-1.7	1.7	-1.7	-1.6	1.4
Bone: trabecular number	1.6	2.5	4.1	-1.5	0.5	-1.3	-2.0	2.0
Bone: trabecular spacing	2.1	2.7	5.6	1.2	0.3	1.2	2.2	-2.4
Bone: trabecular thickness	2.9	3.4	7.8	-1.0	-1.3	-1.2	-2.3	2.8
Bone: trabecular tissue density	6.2	8.7	10.9	3.3	-2.8	3.1	3.0	-2.6
Water consumed over 24 hours	0.4	0.5	1.7	0.6	-1.3	0.5	-0.1	0.4
Number of responses in last shaping day	0.8	0.8	1.8	-0.7	0.8	-1.3	-0.7	0.8