Epn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	intron excision ratio	chr1_77786232_77787609	0.1	0.07	1.9e-03	0.01	0.01	-0.01	0	7.2e-02	1.6e-01	9.2e-01	2.6e-01
2	BLA	intron excision ratio	chr1_77773661_77773795	0.19	0.23	1.3e-03	0.03	0.03	0.01	0.03	9.1e-03	1.5e-02	5.8e-02	1.3e-02
3	BLA	intron excision ratio	chr1_77773664_77773795	0.17	0.2	9.7e-04	0.03	0.03	0.02	0.03	6.3e-03	1.1e-02	4.6e-02	8.5e-03
4	NAcc	intron excision ratio	chr1_77786232_77789209	0.01	0.01	8.0e-03	0	0.01	0	0	6.7e-02	2.7e-02	5.0e-02	5.5e-02
5	NAcc	gene expression	Epn1	0.02	0.02	8.7e-04	0.01	0.01	0.01	0.01	2.5e-02	5.9e-03	3.2e-02	1.1e-02
6	Brain	intron excision ratio	chr1_77786232_77789209	0.03	0.03	2.8e-04	0.03	0.03	0.03	0.03	5.0e-04	1.3e-03	2.0e-03	1.3e-03
7	Brain	gene expression	Epn1	0.06	0.04	3.8e-06	0.04	0.06	0.02	0.04	2.9e-04	5.2e-06	3.0e-03	1.7e-04
8	pVTA	intron excision ratio	chr1_77786232_77789048	0.04	0.04	8.8e-03	0.01	0.01	0	0.01	6.8e-02	9.7e-02	1.8e-01	8.5e-02
9	PL	intron excision ratio	chr1_77786232_77789048	0.03	0.03	8.7e-03	0.01	0	0.01	0.01	6.9e-02	7.4e-02	8.5e-03	6.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.2	0.3	-0.3	0.4	-0.4	-0.5	0.4	0.2	0.6	0.4	0.5
Area under the delay curve	0.4	0.7	1.1	0.7	-0.7	0.7	0.7	-0.7	-1.0	-0.6	-1.0	-1.1
BMI with tail	0.5	1.8	2.4	1.5	-1.5	1.5	1.4	-1.3	-1.1	-1.4	-1.2	-0.9
BMI without tail	0.0	0.2	0.3	-0.5	0.5	-0.5	-0.4	0.6	0.2	0.0	-0.2	0.3
Body weight	0.9	3.9	5.9	-2.3	2.0	-2.0	-2.1	2.3	2.4	1.5	1.6	1.2
Weight adjusted by age	0.2	0.7	1.5	-0.7	0.7	-0.7	-0.9	0.6	0.5	1.2	1.2	-0.0
Bone surface	2.7	5.4	6.6	-2.5	2.4	-2.4	-2.4	2.4	2.6	2.2	2.1	1.8
Bone volume	2.2	4.4	5.2	-2.1	2.1	-2.1	-2.3	2.2	2.1	2.1	1.9	1.8
Breakpoint value in progressive ratio session	0.2	0.4	0.7	0.8	-0.8	0.8	0.8	-0.7	0.1	-0.7	-0.3	-0.0
Number of licking bursts	0.0	0.1	0.2	0.3	-0.3	0.3	0.4	-0.3	-0.1	-0.4	-0.4	-0.2
Context. condit. distance diff. score	0.3	0.3	1.2	0.4	-0.5	0.5	0.5	-0.8	0.0	-0.2	0.5	-1.1
Locomotion velocity, session 1	0.6	0.7	1.8	0.4	-0.1	0.1	0.0	-0.8	-0.9	1.0	1.3	-1.4
Locomotion distance, session 1	2.3	3.0	7.5	-1.4	1.7	-1.7	-1.7	1.1	1.5	2.3	2.7	0.4
Locomotion velocity, session 2	0.1	0.2	0.4	0.6	-0.3	0.3	0.3	-0.6	-0.6	0.2	0.3	-0.3
Locomotion distance, session 2	1.6	2.3	4.0	-1.5	1.8	-1.8	-1.7	1.4	0.9	2.0	1.5	0.4
Locomotion velocity, session 3	0.1	0.1	0.2	0.3	-0.2	0.2	0.2	-0.3	-0.1	0.0	0.5	0.3
Locomotion distance, session 3	0.3	0.3	1.3	-0.3	0.4	-0.4	-0.4	0.2	0.5	0.8	1.1	0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.3	-0.5	0.5	0.4	-0.3	0.3	-0.5	0.3	0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.3	-0.5	0.5	0.4	-0.3	0.2	-0.5	0.2	0.3
Locomotion velocity, session 7	0.2	0.2	1.2	-0.1	0.1	-0.1	-0.2	0.0	0.4	0.5	1.1	0.3
Locomotion distance, session 7	0.1	0.1	0.5	0.1	-0.2	0.2	-0.1	-0.2	-0.3	0.6	0.3	-0.7
Stereotopy head waving bouts, day 7	0.4	0.5	1.5	-0.5	0.4	-0.4	-0.3	0.4	1.2	0.0	0.8	1.2
Stereotopy head waving duration, day 7	0.3	0.4	1.4	-0.5	0.3	-0.3	-0.3	0.5	1.1	0.0	0.7	1.2
Locomotion velocity, session 8	0.2	0.2	1.2	0.3	-0.1	0.1	0.0	-0.4	0.2	0.5	1.1	-0.1
Locomotion distance, session 8	0.2	0.3	1.0	-0.3	0.4	-0.4	-0.3	-0.1	0.3	0.8	1.0	-0.9
Degree of sensitization distance	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.0	0.1	0.1	0.0	-0.3
Degree of sensitization stereotypy	0.1	0.2	0.6	-0.2	0.2	-0.2	-0.0	0.2	0.7	-0.2	0.3	0.8
Conditioned locomotion	0.1	0.1	0.8	0.1	-0.1	0.1	-0.1	-0.2	0.5	0.4	0.9	-0.0
Cocaine response after cond. corrected	1.2	1.8	4.5	1.3	-1.2	1.2	1.2	-0.8	-1.5	-1.7	-2.1	0.3
Cocaine response after cond. not corrected	0.2	0.3	1.0	-0.3	0.5	-0.5	-0.3	0.7	-0.2	-0.1	-0.7	1.0
Cocaine response before conditioning	6.7	8.1	10.1	-3.1	3.2	-3.2	-3.0	2.7	2.8	3.0	2.9	1.1
Saline control response	0.4	0.5	3.5	0.3	-0.3	0.3	-0.1	-0.3	0.6	0.7	1.9	0.3
Bone: connectivity density	0.0	0.0	0.1	0.3	-0.2	0.2	0.1	-0.1	-0.3	-0.1	-0.2	0.1
Bone: cortical apparent density	0.2	0.3	1.1	0.0	0.1	-0.1	-0.4	0.1	-1.1	0.8	-0.3	-0.7
Bone: cortical area	0.8	1.3	2.4	-1.3	1.0	-1.0	-1.1	1.0	1.6	0.9	1.4	0.6
Bone: cortical porosity	0.5	0.5	1.5	0.8	-0.7	0.7	0.6	-0.5	0.4	-0.8	-0.2	1.2
Bone: cortical porosity	0.4	0.5	2.7	0.3	-0.2	0.2	0.2	-0.0	1.0	-0.5	0.2	1.7
Bone: cortical thickness	0.2	0.4	0.7	0.8	-0.9	0.9	0.7	-0.8	-0.4	-0.4	0.1	-0.1
Bone: cortical thickness	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.4	0.2	-0.4	0.5	-0.4	-0.6
Bone: cortical tissue density	0.2	0.3	1.2	0.0	0.1	-0.1	-0.3	0.1	-1.1	0.7	-0.4	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.5	-0.5	0.5	0.5	-0.4	0.1	-0.4	0.2	0.6
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.2	1.4	-1.5	1.5	1.5	-1.4	-1.0	-1.5	-1.0	-0.6
Condit. Reinf. active responses	0.4	0.5	1.7	-0.3	0.5	-0.5	-0.4	0.4	1.0	0.4	1.1	1.3
Condit. Reinf. inactive responses	3.6	4.6	6.4	-2.0	2.2	-2.2	-2.2	1.9	2.3	2.2	2.5	1.7
Incentive salience index mean	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.3	0.2	0.4	0.3	0.6	0.5
Condit. Reinf. lever presses	0.6	0.9	1.4	-1.0	1.0	-1.0	-1.2	1.0	0.4	1.2	0.5	0.4
Condit. Reinf. active minus inactive responses	2.8	4.3	6.5	-2.3	2.1	-2.1	-2.2	2.2	2.6	2.0	1.8	1.2
Condit. Reinf. active-inactive response ratio	3.8	6.0	8.1	-2.8	2.6	-2.6	-2.7	2.8	2.6	2.3	1.4	1.7
Condit. Reinf. active responses	2.6	3.8	7.0	-2.1	1.9	-1.9	-1.9	1.7	2.7	2.0	2.2	0.8
Condit. Reinf. inactive responses	0.2	0.3	1.2	0.0	-0.0	0.0	0.2	-0.4	0.9	0.0	1.1	-0.3
Condit. Reinf. lever presses	0.7	1.0	3.4	-1.0	0.9	-0.9	-0.7	1.0	1.8	0.1	0.7	1.0
Condit. Reinf. lever reinforcers received	3.5	5.0	8.6	-2.4	2.2	-2.2	-2.2	2.0	2.9	2.3	2.5	0.9
Conditioned reinforcement - actives	0.1	0.3	0.4	-0.6	0.6	-0.6	-0.7	0.6	-0.6	0.6	0.2	0.1
Conditioned reinforcement - inactives	1.0	2.8	4.4	-2.1	1.9	-1.9	-2.1	1.8	0.5	2.1	1.1	0.3
Conditioned locomotion	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.4	0.4	-0.1	0.3	-0.3	0.0
Patch foraging indifference point 0 sec	0.2	0.6	1.3	0.9	-0.8	0.8	0.8	-1.2	-0.1	-0.3	0.7	-0.7
Patch foraging indifference point AUC	0.2	0.5	0.8	0.9	-0.8	0.8	0.8	-0.8	-0.8	-0.8	-0.5	-0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	0.3	-0.3	0.3	0.1	-0.4	-0.5	0.5	0.4	-0.9
Delay disc. indifference point, 16s delay	0.5	0.7	2.5	0.6	-0.6	0.6	0.9	-0.5	-0.3	-1.3	-1.6	0.3
Delay disc. indifference point, 2s delay	1.2	1.4	3.8	0.9	-0.9	0.9	0.7	-0.8	-1.9	-0.5	-1.4	-1.6
Delay disc. indifference point, 24s delay	0.4	0.7	2.3	0.7	-0.7	0.7	0.9	-0.7	-0.5	-1.1	-1.5	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.2	0.3	-0.3	0.1	-0.3	-0.2
Delay disc. indifference point, 8s delay	0.1	0.2	0.8	0.3	-0.3	0.3	0.4	-0.5	-0.6	-0.2	-0.4	-0.9
Indifference point function ln k	2.1	6.5	8.7	-2.8	2.6	-2.6	-2.8	2.5	2.5	3.0	2.5	1.2
Indifference point function log k	2.1	6.5	8.7	-2.8	2.6	-2.6	-2.8	2.5	2.5	3.0	2.5	1.2
Patch foraging total patch changes 0 sec	0.2	0.6	1.3	0.9	-0.8	0.8	0.8	-1.2	-0.2	-0.3	0.4	-0.9
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	0.5	-0.4	0.4	0.6	-0.7	-0.1	-0.6	0.1	-0.3
Patch foraging total patch changes 18 sec	0.3	0.7	1.5	1.0	-1.0	1.0	1.1	-1.2	0.0	-0.9	0.4	-0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	-0.2	0.3	-0.3	-0.0	0.2	0.3	-0.3	-0.4	0.4
Patch foraging total patch changes 6 sec	0.6	1.0	1.9	1.1	-1.1	1.1	1.3	-1.4	-0.5	-1.1	-0.1	-0.6
Patch foraging time to switch 0 sec	0.8	3.2	8.0	1.5	-1.6	1.6	1.9	-1.1	-1.4	-2.8	-2.6	0.3
Patch foraging water rate 0 sec	0.2	0.8	1.8	-0.8	0.8	-0.8	-0.8	0.4	0.7	1.4	1.3	-0.6
Patch foraging water rate 12 sec	0.6	2.6	4.8	-1.7	1.6	-1.6	-1.6	1.0	1.4	2.2	2.2	-0.5
Patch foraging water rate 18 sec	0.5	1.1	2.3	-1.0	1.0	-1.0	-1.1	0.7	1.0	1.4	1.5	-0.1
Patch foraging water rate 24 sec	0.7	1.0	1.9	-1.0	1.0	-1.0	-1.0	0.8	1.1	1.3	1.4	0.3
Patch foraging water rate 6 sec	5.2	7.7	9.0	-3.0	3.0	-3.0	-2.9	3.0	2.9	2.6	2.5	2.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.6	0.1	-0.1	0.1	-0.0	-0.5	0.4	0.7	1.3	-0.9
Distance traveled before self-admin	0.8	1.7	4.7	-1.0	1.0	-1.0	-1.4	0.7	1.1	2.2	2.0	-0.5
Distance traveled after self-admin	0.4	0.6	1.4	0.9	-0.9	0.9	0.6	-1.2	0.5	0.1	0.4	-1.0
Extensor digitorum longus weight	0.2	0.6	1.2	-1.1	0.7	-0.7	-0.9	1.0	1.0	0.5	0.4	0.6
Bone: elastic displacement	0.3	0.4	1.2	0.7	-0.8	0.8	0.5	-0.7	0.2	-0.2	1.1	0.4
Bone: elastic work	0.5	0.6	2.1	-0.8	0.5	-0.5	-0.8	0.6	0.5	1.0	1.5	0.0
Bone: endosteal estimation	2.1	5.2	8.2	-2.9	2.5	-2.5	-2.4	2.6	2.3	2.0	1.7	0.9
Bone: endosteal perimeter	1.3	3.2	5.0	-2.2	1.9	-1.9	-1.8	1.8	2.1	1.6	1.7	0.4
Epididymis fat weight	0.0	0.2	0.6	-0.3	0.0	-0.0	0.1	0.4	0.3	-0.8	-0.7	0.4
Delta time in closed arm before/after self-admin	0.2	0.2	1.0	0.0	0.0	-0.0	0.1	-0.2	-1.0	-0.0	-0.5	-0.5
Delta time in open arm before/after self-admin	1.6	1.9	4.3	-1.1	1.1	-1.1	-1.2	1.0	2.1	1.4	2.0	1.2
Diff in mean of infusions in LGA sessions	0.1	0.2	0.6	0.1	-0.0	0.0	-0.0	-0.2	-0.6	0.4	0.6	-0.8
Delay discount exponential model param	0.4	0.5	1.0	-0.5	0.5	-0.5	-0.6	0.6	0.9	0.6	1.0	1.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	-0.4	0.4	0.3	-0.4	0.3	-0.1	-0.0	-0.4
Active lever presses in extinction session 6	0.3	0.3	1.3	0.1	-0.1	0.1	0.2	0.2	0.3	-0.8	-1.1	0.6
Bone: final force	1.7	2.8	4.3	-2.1	1.9	-1.9	-2.0	2.0	1.0	1.8	1.1	0.5
Bone: final moment	2.2	3.6	5.3	-2.3	2.1	-2.1	-2.3	2.2	1.1	2.1	1.5	0.6
Food consumed during 24 hour testing period	1.0	2.0	2.7	-1.6	1.6	-1.6	-1.5	1.5	1.3	1.5	1.2	0.4
Glucose	1.7	2.7	3.9	1.7	-1.7	1.7	1.8	-2.0	-1.5	-1.3	-1.0	-1.9
Heart weight	1.2	2.0	3.0	-1.7	1.7	-1.7	-1.6	1.7	1.0	1.2	0.4	1.1
Delay discount hyperbolic model param	0.6	0.7	1.5	-0.6	0.6	-0.6	-0.7	0.7	1.1	0.6	1.1	1.2
Intermittent access intake day 1-15 change	0.1	0.7	1.2	-0.9	0.9	-0.9	-1.1	1.1	0.8	0.9	0.4	0.4
Intermittent access intake escalation	0.2	1.2	2.1	-1.2	1.1	-1.1	-1.3	1.5	1.1	1.0	0.4	0.6
Intermittent access intake escalation 2	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.4	0.3	0.4	0.6	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.2	2.1	3.1	-1.6	1.6	-1.6	-1.6	1.7	1.3	1.2	0.7	1.3
Intermitt. access day 15 inactive lever presses	0.8	4.3	5.9	-2.4	2.3	-2.3	-2.3	2.4	1.9	1.8	0.9	2.0
Intermitt. access escalation Index	0.3	1.0	2.2	0.9	-1.0	1.0	0.8	-0.9	-0.8	-0.6	-1.2	-1.5
Intermittent access day 1 total infusions	0.1	0.4	0.7	-0.8	0.8	-0.8	-0.8	0.8	0.1	0.7	0.3	0.1
Intermittent access day 15 total infusions	0.4	0.9	1.8	-1.1	1.0	-1.0	-1.2	1.4	0.4	0.9	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.4	0.7	1.5	-1.0	0.9	-0.9	-1.2	1.2	0.1	0.9	-0.1	-0.1
Intermittent access total infusions	1.1	1.3	2.3	-1.3	1.3	-1.3	-1.5	1.5	0.2	1.3	0.4	0.3
Intermittent access day 1 locomotion	0.5	1.0	1.7	-1.3	1.2	-1.2	-1.3	1.2	0.1	1.2	-0.0	-0.2
Intermittent access day 15 total locomotion	0.2	1.0	1.9	-1.1	1.0	-1.0	-1.2	1.0	0.2	1.4	0.5	-0.9
Intermittent access total locomotion	1.9	2.3	3.8	-1.8	1.7	-1.7	-1.9	1.9	0.7	1.9	0.6	-0.1
Intermittent access standard deviation	0.1	0.7	1.3	0.9	-0.9	0.9	0.6	-0.6	-0.8	-0.5	-0.8	-1.1
Left kidney weight	2.8	22.6	29.0	-5.2	5.0	-5.0	-4.9	4.9	5.4	4.3	4.5	3.0
Right kidney weight	3.3	23.0	29.5	-5.4	5.3	-5.3	-4.9	5.1	5.3	4.1	4.1	3.3
Cocaine induced anxiety	0.6	1.7	3.6	-1.1	1.1	-1.1	-1.2	1.1	1.9	1.1	1.4	1.3
Post-drug Anxiety	1.0	1.2	3.3	-0.8	0.8	-0.8	-0.8	1.0	1.8	0.4	0.8	1.6
Baseline Anxiety	0.4	0.8	1.1	0.9	-0.9	0.9	0.9	-0.7	-1.0	-1.0	-1.0	-0.5
Tail length	2.2	11.7	14.9	-3.9	3.7	-3.7	-3.6	3.7	3.5	3.1	2.8	2.4
Length with tail	2.5	11.2	14.9	-3.9	3.6	-3.6	-3.5	3.8	3.7	2.8	2.6	2.3
Length without tail	0.7	3.7	5.7	-2.2	2.0	-2.0	-1.9	2.4	2.3	1.1	1.2	1.7
Times rat made contact with spout	0.1	0.1	0.2	0.2	-0.2	0.2	0.3	-0.2	-0.1	-0.5	-0.2	0.0
Lifetime Intake	0.7	0.9	1.6	-1.1	1.1	-1.1	-1.3	1.3	-0.1	1.1	0.2	0.1
Liver weight, left	0.8	1.4	2.0	-1.4	1.4	-1.4	-1.2	1.3	1.2	1.0	0.8	0.4
Liver weight, right	0.0	0.1	0.3	-0.2	0.1	-0.1	0.1	-0.2	0.6	-0.0	0.4	-0.3
Locomotor activity	0.2	0.2	0.5	0.2	-0.3	0.3	0.5	-0.4	-0.5	-0.6	-0.7	-0.7
Locomotor testing distance	0.0	0.1	0.4	-0.4	0.2	-0.2	-0.0	0.3	-0.1	-0.4	-0.6	-0.1
Locomotor testing rearing	0.2	0.6	1.0	-1.0	1.0	-1.0	-0.7	0.7	0.8	0.5	0.5	-0.2
Locomotion in novel chamber	1.7	2.3	2.8	1.7	-1.6	1.6	1.5	-1.6	-1.4	-1.2	-1.3	-1.5
Locomotion in novel chamber post-restriction	0.4	1.2	2.5	1.0	-0.9	0.9	1.0	-1.0	-1.6	-0.9	-1.4	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	-0.6	0.6	-0.6	-0.5	0.4	0.1	0.5	0.3	-0.6
Change in fecal boli incidents, locomotor task	3.0	3.2	4.9	1.9	-1.9	1.9	1.7	-1.8	-2.2	-1.4	-1.7	-1.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.0	-0.2	-0.2	-0.1	0.2
Bouts of movement, locomotor time 1	0.4	0.6	2.1	-0.3	0.3	-0.3	-0.4	-0.1	0.3	1.1	1.5	-1.0
Total resting periods, locomotor time 1	0.2	0.3	1.5	0.1	-0.1	0.1	0.1	-0.5	-0.2	0.4	0.6	-1.2
Rest time, locomotor task time 1	0.7	1.1	1.9	-1.4	1.4	-1.4	-1.2	1.2	0.6	1.0	0.4	-0.1
Distance moved, locomotor task time 1	0.5	1.3	2.1	1.4	-1.4	1.4	1.4	-1.4	-0.5	-1.2	-0.5	-0.1
Vertical activity count, locomotor time 1	0.5	3.2	5.2	2.2	-2.2	2.2	2.0	-2.3	-1.5	-1.3	-0.5	-1.4
Time >=10cm from walls, locomotor time 2	0.2	0.7	0.9	0.9	-0.9	0.9	0.8	-0.7	-0.9	-0.9	-0.9	0.1
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.1	0.0	0.0	0.1	0.0	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.3	-0.2	0.2	-0.2	-0.1	0.0	-0.2	0.2	-0.0	-0.5
Rest time, locomotor task time 2	0.1	0.1	0.6	-0.0	0.0	-0.0	-0.1	-0.2	-0.3	0.4	0.3	-0.7
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.5	-0.5	0.5	0.4	-0.4	0.1	-0.4	-0.0	0.4
Vertical activity count, locomotor time 2	0.1	0.3	0.7	0.6	-0.6	0.6	0.6	-0.7	-0.4	-0.4	-0.1	-0.9
Light reinforcement 1	0.1	0.4	1.7	0.6	-0.4	0.4	-0.1	-0.5	-0.1	0.8	1.3	0.0
Light reinforcement 2	0.9	1.9	3.3	1.7	-1.8	1.8	1.3	-1.5	-1.5	-0.9	-0.6	-0.8
Bone: marrow area	2.1	5.2	8.3	-2.9	2.5	-2.5	-2.4	2.6	2.3	2.0	1.7	1.0
Bone: maximum diameter	0.8	1.7	3.2	-1.6	1.3	-1.3	-1.2	1.3	1.8	0.8	1.3	0.6
Bone: maximum force	2.3	4.6	7.0	-2.6	2.3	-2.3	-2.4	2.4	1.8	2.1	1.8	0.9
Bone: maximum moment	2.8	5.2	7.8	-2.8	2.4	-2.4	-2.6	2.6	1.9	2.3	2.1	0.9
Mean time between licks in bursts	0.1	0.7	1.1	1.0	-1.0	1.0	0.7	-0.9	-1.0	-0.3	-0.5	-0.8
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	0.4	-0.4	-0.3	0.4	0.1	0.2	0.2	-0.0
Cd content in liver	1.8	2.0	2.5	-1.6	1.6	-1.6	-1.6	1.5	1.5	1.6	1.1	0.4
Co content in liver	0.6	0.7	2.5	-0.7	0.6	-0.6	-1.2	0.9	-0.2	1.6	0.8	0.2
Cu content in liver	1.0	1.2	2.5	-1.0	1.0	-1.0	-1.2	1.3	0.8	1.0	0.7	1.6
Fe content in liver	0.3	0.4	0.9	-0.6	0.5	-0.5	-0.7	0.7	0.5	0.6	0.5	1.0
K content in liver	0.1	0.1	0.6	0.1	0.1	-0.1	-0.1	0.1	0.4	0.0	0.4	0.8
Mg content in liver	0.1	0.1	0.7	0.3	-0.2	0.2	0.2	-0.0	0.1	-0.5	-0.2	0.8
Mn content in liver	0.4	0.4	2.2	0.1	-0.1	0.1	0.1	0.1	1.0	-0.4	0.6	1.5
Na content in liver	2.2	2.4	4.1	2.0	-1.9	1.9	1.8	-1.8	-1.0	-1.6	-0.7	-0.0
Rb content in liver	3.6	4.2	7.2	-1.8	2.0	-2.0	-1.9	2.1	2.3	1.4	2.0	2.7
Se content in liver	1.9	2.2	3.8	1.5	-1.8	1.8	1.8	-1.6	-0.7	-2.0	-1.1	-0.6
Sr content in liver	5.9	5.1	7.3	2.6	-2.6	2.6	2.2	-2.6	-2.7	-1.4	-1.0	-1.8
Zn content in liver	0.6	0.7	3.1	0.6	-0.4	0.4	0.7	-0.3	-0.7	-1.1	-1.7	0.1
Bone: minimum diameter	3.1	5.9	7.9	-2.7	2.6	-2.6	-2.4	2.3	2.8	2.2	2.7	1.3
Time in familiar zone, hab. session 1	2.1	2.3	4.5	-1.8	1.5	-1.5	-1.7	1.2	0.7	2.1	1.2	-1.4
Time in novel zone, hab. session 1	1.7	1.9	3.2	1.8	-1.6	1.6	1.6	-1.3	-0.7	-1.7	-0.7	1.1
Total zone transitions, hab. session 1	0.8	1.1	3.4	-0.5	0.9	-0.9	-1.1	0.5	0.3	1.9	1.8	0.0
Total locomotion distance, hab. session 1	0.3	0.4	1.4	-0.2	0.4	-0.4	-0.5	0.0	-0.1	1.2	0.9	-0.6
Locomotion velocity, hab. session 1	0.2	0.3	1.1	-0.1	0.4	-0.4	-0.5	0.1	-0.1	1.0	0.7	-0.4
Time in familiar zone, hab. session 2	2.1	2.4	4.2	-2.0	1.9	-1.9	-1.6	1.9	1.5	1.0	0.5	0.6
Time in novel zone, hab. session 2	1.3	1.4	2.6	1.6	-1.6	1.6	1.2	-1.4	-1.0	-0.9	-0.4	0.0
Total zone transitions, hab. session 2	2.3	3.0	6.6	-1.5	1.8	-1.8	-1.7	1.2	1.8	2.1	2.6	0.4
Total locomotion distance, hab. session 2	0.2	0.2	0.8	0.0	0.2	-0.2	-0.1	-0.3	-0.0	0.7	0.9	-0.8
Locomotion velocity, hab. session 2	0.2	0.2	0.8	0.2	0.0	-0.0	-0.0	-0.4	-0.1	0.6	0.9	-0.8
Novel to familiar place preference ratio	0.0	0.0	0.2	-0.2	0.1	-0.1	-0.0	0.1	0.4	-0.1	0.2	0.2
Novelty place preference	0.1	0.1	0.4	-0.4	0.3	-0.3	-0.3	0.3	0.6	0.2	0.4	0.3
Time in novel zone, NPP test	0.1	0.1	0.4	-0.5	0.4	-0.4	-0.3	0.3	0.6	0.2	0.4	0.1
Total zone transitions, NPP test	0.3	0.4	1.0	-0.5	0.8	-0.8	-0.5	0.2	0.2	0.9	1.0	-0.6
Total locomotion distance, NPP test	0.3	0.5	0.9	-0.6	0.9	-0.9	-0.6	0.5	0.7	0.7	1.0	0.1
Locomotion velocity, NPP test	0.4	0.6	1.5	-0.6	0.9	-0.9	-0.6	0.4	0.8	0.8	1.2	0.1
Intraocular pressure	0.1	0.1	0.6	0.4	-0.3	0.3	0.1	-0.0	-0.3	0.0	0.3	0.8
Delta distance traveled before/after self-admin	1.7	1.9	2.7	1.6	-1.6	1.6	1.7	-1.6	-0.7	-1.6	-1.0	-0.5
Delta ambulatory time before/after self-admin	0.8	1.3	1.9	1.3	-1.3	1.3	1.4	-1.4	-0.9	-1.3	-0.7	-0.6
Parametrial fat weight	1.9	4.4	5.2	2.0	-2.0	2.0	2.3	-2.1	-2.0	-2.2	-2.2	-2.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.4	-0.5	0.5	0.3	-0.3	-0.2	-0.2	0.0	0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	2.0	0.9	-0.7	0.7	0.9	-0.7	-0.9	-1.1	-1.4	-0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.6	-0.5	0.5	0.6	-0.6	-0.7	-0.5	-0.5	-0.6
Pavlov. Cond. index score	0.3	0.4	1.0	0.6	-0.4	0.4	0.6	-0.6	-0.8	-0.6	-1.0	-0.6
Pavlov. Cond. latency score	0.3	0.4	1.0	0.4	-0.3	0.3	0.5	-0.5	-0.7	-0.6	-1.0	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	0.5	-0.5	-0.2	0.3	0.4	-0.0	-0.0	0.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.9	-0.5	0.4	-0.4	-0.5	0.4	0.6	0.7	0.9	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.4	2.4	0.4	-0.3	0.3	0.2	-0.6	0.2	0.5	1.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.6	-0.5	0.5	0.6	-0.6	-0.7	-0.7	-0.9	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.5	0.0	0.1	-0.1	0.1	0.1	-0.2	-0.4	-0.7	0.3
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.7	0.8	-0.8	-0.6	0.5	-0.2	0.7	0.2	-0.2
Pavlov. Cond. magazine entry latency	0.5	0.8	1.4	0.9	-1.1	1.1	1.0	-0.8	-0.4	-1.2	-0.6	-0.1
Pavlov. Cond. change in total contacts	0.2	0.5	1.3	-0.2	-0.0	0.0	-0.4	0.4	1.2	0.4	1.1	1.0
Pavlov. Cond. index score	0.1	0.2	0.6	0.3	-0.4	0.4	0.2	-0.0	0.5	-0.4	0.2	0.8
Pavlov. Cond. latency score	0.2	0.4	0.7	0.7	-0.8	0.8	0.6	-0.4	0.1	-0.8	-0.2	0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.4	-0.5	0.5	0.3	-0.1	0.5	-0.4	0.0	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	-0.8	0.9	-0.9	-0.7	0.6	0.5	0.8	0.8	0.2
Pavlov. Cond. intertrial magazine entries	1.9	4.2	5.1	-2.2	2.3	-2.3	-2.2	2.1	2.1	2.1	1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.4	-0.5	0.5	0.3	-0.1	0.3	-0.4	-0.0	0.6
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.3	0.2	-0.2	-0.4	0.5	1.0	0.2	0.6	1.0
Time in closed arm before self-admin	0.6	1.0	1.6	-1.0	0.9	-0.9	-1.0	1.0	1.2	0.9	1.2	1.1
Time in closed arm after self-admin	0.2	0.2	0.6	-0.5	0.5	-0.5	-0.3	0.5	-0.1	0.0	0.2	0.8
Time in open arm before self-admin	1.9	2.3	4.2	1.4	-1.4	1.4	1.6	-1.6	-2.1	-1.4	-1.3	-1.3
Time in open arm after self-admin	0.2	0.2	0.4	0.6	-0.6	0.6	0.5	-0.7	0.1	-0.1	0.1	-0.5
Bone: periosteal estimation	1.7	4.0	6.0	-2.4	2.1	-2.1	-2.1	2.1	2.3	1.8	1.9	0.9
Bone: periosteal perimeter	1.4	2.8	4.1	-2.0	1.6	-1.6	-1.7	1.7	2.0	1.5	1.8	0.9
Bone: post-yield work	2.5	4.3	5.8	-2.4	2.2	-2.2	-2.1	2.4	2.4	1.5	1.4	1.8
Progressive ratio test 1 active lever presses	0.6	1.0	3.2	-0.8	0.8	-0.8	-1.1	0.7	0.0	1.5	1.8	0.1
Progressive ratio test 1 breakpoint	0.6	1.0	3.0	-0.9	0.8	-0.8	-1.1	0.7	-0.0	1.5	1.7	0.1
Progressive ratio test 1 inactive lever presses	1.4	3.7	5.3	-2.2	2.1	-2.1	-2.3	2.1	0.8	2.3	1.7	0.9
Progressive ratio test 2 active lever presses	0.4	0.6	1.1	-0.8	0.8	-0.8	-1.0	1.1	0.2	0.7	0.5	0.7
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-0.9	0.9	-0.9	-1.0	1.2	0.3	0.7	0.5	0.8
Progressive ratio test 2 inactive lever presses	1.2	3.9	5.5	-2.3	2.2	-2.2	-2.3	2.3	1.3	2.2	1.4	0.9
Incentive Sensitization - Responses	0.6	1.7	3.0	-1.4	1.4	-1.4	-1.4	1.7	1.4	0.8	0.5	1.4
Incentive Sensitization - Breakpoint	0.5	1.2	2.2	-1.1	1.1	-1.1	-1.1	1.5	1.2	0.5	0.3	1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.3	-0.3	0.3	0.2	-0.4	0.6	0.1	0.1	-0.3
Progressive ratio	0.1	0.2	0.9	-0.0	0.2	-0.2	-0.0	-0.2	0.6	0.3	0.9	-0.1
Food seeking constrained by brief footshock	1.2	1.5	5.5	0.2	-0.1	0.1	-0.2	-1.0	-0.2	1.7	2.3	-1.9
Seeking ratio, punishment vs. effort	0.2	0.4	1.0	-0.6	0.5	-0.5	-0.7	0.4	0.2	1.0	0.7	-0.3
Retroperitoneal fat weight	3.7	16.7	22.6	4.1	-4.2	4.2	4.4	-3.9	-3.9	-4.7	-4.5	-2.6
Reaction time number correct	0.2	0.8	3.5	0.4	-0.6	0.6	0.5	-0.6	-1.2	-0.3	-0.8	-1.9
Reaction time mean minus median	0.0	0.2	0.9	0.0	0.1	-0.1	-0.0	0.0	-0.7	0.0	-0.9	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.8	0.0	-0.0	0.0	0.1	-0.0	-0.5	-0.2	-0.9	-0.5
Reaction time num false alarms	0.0	0.1	0.2	0.2	-0.2	0.2	-0.1	0.1	-0.3	0.1	-0.4	0.3
Reaction time num false alarms AUC	0.1	0.3	0.7	0.7	-0.7	0.7	0.3	-0.5	-0.8	-0.0	-0.5	-0.3
Reaction time trials correct on left	0.2	0.8	3.5	0.4	-0.6	0.6	0.5	-0.6	-1.2	-0.3	-0.8	-1.9
Reaction time trials on left	0.2	0.8	3.4	0.4	-0.6	0.6	0.5	-0.6	-1.2	-0.3	-0.8	-1.8
Reaction time mean	0.5	1.0	1.9	-1.1	1.1	-1.1	-1.1	1.4	0.6	0.7	-0.1	1.3
Reaction time mean AUC	0.2	0.4	0.9	-0.7	0.7	-0.7	-0.7	1.0	0.1	0.2	-0.6	0.9
Median of all reaction times	0.8	1.2	2.8	-1.1	1.1	-1.1	-1.1	1.4	0.7	0.6	0.0	1.7
Reaction time omissions	0.0	0.1	0.1	0.4	-0.4	0.4	0.0	-0.2	-0.4	0.3	0.1	-0.1
Reaction time false alarm rate	0.1	0.1	0.4	0.4	-0.4	0.4	0.0	-0.1	-0.1	0.2	0.0	0.6
Reaction time premature initiation rate	0.0	0.1	0.2	-0.2	0.3	-0.3	-0.0	0.1	-0.1	-0.1	-0.4	-0.2
Reaction time premature initiations	0.1	0.3	1.1	0.1	-0.1	0.1	0.3	-0.2	-0.7	-0.5	-0.9	-1.0
Std. dev. reaction times	0.2	0.5	1.0	-0.8	0.9	-0.9	-0.8	1.0	0.4	0.5	-0.4	0.5
Reaction time trials completed	0.2	0.8	3.4	0.4	-0.6	0.6	0.5	-0.6	-1.2	-0.3	-0.8	-1.8
Reaction time trials AUC	0.2	0.7	3.4	0.4	-0.5	0.5	0.5	-0.5	-1.1	-0.4	-0.9	-1.8
Run reversals in cocaine runway, females	0.6	0.7	2.0	-0.8	0.8	-0.8	-0.7	0.8	0.7	0.4	0.6	1.4
Run reversals in cocaine runway, males	0.0	0.0	0.2	-0.1	-0.0	0.0	-0.2	0.2	-0.5	0.1	0.0	0.3
Latency to leave start box in cocaine runway	0.4	0.5	0.9	-0.8	0.8	-0.8	-0.8	0.9	0.5	0.7	0.2	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.4	-0.0	0.3	-0.1	-0.1
Latency to leave start box in cocaine runway, M	1.2	1.2	1.8	-1.1	1.1	-1.1	-1.2	1.3	1.1	0.9	0.6	1.1
Std. dev. time between licks in bursts	0.1	0.3	0.7	0.5	-0.5	0.5	0.1	-0.6	-0.3	0.7	0.9	-0.3
Total sessions with >9 infusions	0.8	0.9	2.1	-1.0	1.0	-1.0	-1.2	0.9	0.2	1.4	1.1	-0.0
Short access day 1 total inactive lever presses	0.4	0.8	1.5	-1.1	1.0	-1.0	-1.0	1.2	0.5	0.6	-0.1	0.8
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.5	0.4	-0.4	-0.4	0.6	0.1	0.1	-0.5	-0.0
Short access day 1 total infusions	0.1	0.1	0.6	-0.1	0.1	-0.1	-0.2	0.1	-0.8	0.3	-0.2	-0.5
Short access day 10 total infusions	0.1	0.2	0.8	0.1	-0.1	0.1	0.1	-0.2	-0.9	0.1	-0.3	-0.8
Short access total infusions	0.2	0.3	1.8	0.2	-0.2	0.2	0.1	-0.2	-1.3	0.1	-0.5	-0.8
Short access day 1 locomotion	0.2	0.4	0.7	-0.8	0.7	-0.7	-0.7	0.7	-0.3	0.6	0.1	-0.0
Short access day 10 total locomotion	0.1	0.6	1.5	-0.7	0.7	-0.7	-0.8	0.4	0.1	1.2	0.5	-1.2
Short access total locomotion	0.3	0.5	2.3	-0.3	0.2	-0.2	-0.5	-0.1	-0.7	1.1	0.4	-1.5
One hour access (0.3 mA shock)	3.2	3.8	5.7	-2.2	2.2	-2.2	-2.3	2.4	1.7	2.0	1.2	0.9
Compulsive drug intake	1.4	2.1	4.1	-1.5	1.4	-1.4	-1.4	1.6	2.0	1.1	1.3	1.0
One hour access (shock baseline)	0.2	0.5	0.9	-0.8	0.8	-0.8	-0.9	1.0	-0.3	0.7	-0.3	0.4
Social response proportion	0.8	1.1	2.0	-1.1	1.2	-1.2	-1.1	1.4	0.7	0.6	-0.2	1.2
Social responses	3.3	4.4	5.4	-2.0	2.2	-2.2	-2.2	2.3	2.0	1.9	1.6	2.2
Social time	2.7	4.3	6.5	-2.1	2.3	-2.3	-2.2	1.7	2.0	2.6	2.2	0.5
Soleus weight	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.2	0.1	0.5	0.1	0.3	-0.4
Bone: stiffness	2.0	3.7	5.2	-2.3	2.1	-2.1	-2.2	2.2	1.7	1.8	1.4	1.1
Tibialis anterior weight	0.8	2.7	4.7	1.4	-1.9	1.9	1.9	-1.7	-0.6	-2.2	-1.3	-1.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.6	0.5	-0.5	-0.6	0.4	0.6	0.8	0.8	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	-0.6	0.6	-0.6	-0.5	0.9	0.4	0.1	-0.9	0.3
Time to tail flick, test, before self-admin	0.6	0.7	2.7	0.7	-0.7	0.7	0.4	-0.9	-1.1	0.3	0.4	-1.7
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.3	-0.3	0.3	0.3	-0.3	0.0	-0.4	-0.1	0.6
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	3.5	0.3	-0.3	0.3	0.3	0.1	-0.9	-0.8	-1.9	-0.2
Delta time to tail flick, test, before/after SA	0.6	0.7	3.1	-0.7	0.7	-0.7	-0.4	0.7	1.2	-0.0	0.3	1.8
Tibia length	3.5	9.9	12.7	-3.5	3.5	-3.5	-3.2	3.2	3.6	2.6	2.8	2.0
Ambulatory time before self-admin	0.5	1.6	3.7	-1.0	1.0	-1.0	-1.3	0.8	1.4	1.9	1.9	-0.0
Ambulatory time after self-admin	0.3	0.4	1.6	0.1	-0.2	0.2	-0.1	-0.5	1.1	0.8	1.3	-0.4
Bone: tissue strength	0.5	0.5	3.4	-0.3	0.2	-0.2	-0.3	-0.2	-0.4	0.9	0.5	-1.8
Total heroin consumption	0.1	0.1	0.2	0.2	-0.3	0.3	0.1	-0.2	0.5	0.0	0.3	0.1
Bone: trabecular number	0.1	0.3	0.5	0.5	-0.4	0.4	0.4	-0.5	-0.7	-0.2	-0.6	-0.6
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	0.0	-0.0	0.1	-0.0	0.0	-0.1	0.4	-0.1
Bone: trabecular thickness	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1	0.1	-0.0	0.2	-0.1	0.1
Bone: trabecular tissue density	0.4	0.7	1.7	0.9	-0.8	0.8	1.0	-0.8	-0.4	-1.3	-1.0	0.3
Water consumed over 24 hours	0.5	0.9	1.6	-1.1	1.1	-1.1	-1.1	0.8	0.6	1.3	1.1	-0.2
Number of responses in last shaping day	0.1	0.2	0.7	-0.3	0.3	-0.3	-0.2	0.3	-0.7	0.1	-0.9	-0.0