Hub : Genes

Epm2aip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Epm2aip1	0.13	0.1	7.0e-03	0.08	0.09	0.09	0.08	4.8e-03	3.0e-03	3.7e-03	6.5e-03
2	PL	gene expression	Epm2aip1	0.16	0.08	0.0e+00	0.16	0.16	0.17	0.17	9.8e-18	9.1e-18	2.2e-18	3.3e-18
3	OFC	gene expression	Epm2aip1	0.23	0.12	1.4e-04	0.15	0.08	0.12	0.11	1.7e-04	5.6e-03	1.1e-03	1.5e-03
4	BLA	gene expression	Epm2aip1	0.12	0.07	2.2e-07	0.11	0.13	0.12	0.11	1.9e-06	2.8e-07	7.5e-07	2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.1	-0.3	0.2	-0.1	0.3
Area under the delay curve	2.4	2.6	3.6	1.5	-1.6	-1.4	1.9
BMI with tail	0.8	2.6	5.2	-1.3	1.1	2.3	-1.6
BMI without tail	2.0	4.1	5.7	-1.9	1.8	2.4	-1.8
Body weight	7.4	30.8	32.2	-5.5	5.4	5.7	-5.6
Weight adjusted by age	0.5	0.6	1.0	-0.6	0.6	0.9	-1.0
Bone surface	0.1	0.1	0.2	0.2	-0.2	-0.4	0.3
Bone volume	0.0	0.0	0.1	-0.0	-0.0	-0.2	0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.3	0.3	-0.4	0.1
Number of licking bursts	0.1	0.1	0.2	0.4	-0.4	-0.1	-0.1
Context. condit. distance diff. score	0.1	0.1	0.2	-0.1	0.1	-0.5	-0.2
Locomotion velocity, session 1	0.0	0.1	0.1	0.2	-0.2	-0.0	0.4
Locomotion distance, session 1	0.7	0.9	1.4	-1.2	1.1	0.8	-0.5
Locomotion velocity, session 2	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5
Locomotion distance, session 2	0.1	0.1	0.3	-0.1	0.1	0.2	0.6
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	0.4	0.4	0.2
Locomotion distance, session 3	0.8	0.9	1.8	0.7	-0.8	-0.8	1.3
Stereotopy head waving bouts, day 3	0.3	0.4	1.2	-0.1	0.2	0.5	-1.1
Stereotopy head waving duration, day 3	0.5	0.6	1.2	-0.4	0.5	0.8	-1.1
Locomotion velocity, session 7	0.3	0.3	0.4	-0.7	0.6	0.6	0.1
Locomotion distance, session 7	0.6	0.7	1.6	0.7	-0.8	-0.5	1.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	0.3	-0.4	-0.5	0.8
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.5	0.4	0.2	-0.0
Locomotion velocity, session 8	0.3	0.3	0.6	-0.8	0.7	0.3	-0.3
Locomotion distance, session 8	0.2	0.3	0.6	-0.8	0.7	0.4	0.1
Degree of sensitization distance	1.0	1.0	1.2	-1.0	1.0	1.0	-1.1
Degree of sensitization stereotypy	0.2	0.3	0.8	0.1	-0.1	-0.5	0.9
Conditioned locomotion	3.4	3.9	4.4	1.9	-1.9	-2.0	2.1
Cocaine response after cond. corrected	0.7	0.7	1.6	-0.4	0.3	1.3	-1.0
Cocaine response after cond. not corrected	2.4	2.7	3.9	-1.3	1.3	2.0	-1.9
Cocaine response before conditioning	1.0	1.2	1.7	-1.3	1.3	0.7	-1.0
Saline control response	1.1	1.4	1.9	-1.4	1.3	1.2	-0.8
Bone: connectivity density	0.5	0.7	1.2	0.6	-0.6	-1.0	1.1
Bone: cortical apparent density	0.7	1.0	2.4	0.6	-0.6	-1.5	0.9
Bone: cortical area	0.1	0.2	0.5	0.3	-0.3	-0.7	-0.3
Bone: cortical porosity	0.3	0.3	1.0	0.2	-0.2	-0.4	1.0
Bone: cortical porosity	0.4	0.5	1.2	0.5	-0.5	-0.5	1.1
Bone: cortical thickness	0.2	0.4	1.1	-0.5	0.5	-0.2	-1.1
Bone: cortical thickness	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Bone: cortical tissue density	0.8	1.0	2.5	0.6	-0.6	-1.6	0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	0.3	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.4	0.4	0.5	-0.7
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	-0.3	-0.1	0.2
Condit. Reinf. inactive responses	0.7	0.9	1.2	0.9	-1.0	-0.7	1.1
Incentive salience index mean	0.0	0.1	0.1	0.3	-0.3	-0.1	0.2
Condit. Reinf. lever presses	1.3	1.8	2.1	1.4	-1.4	-1.1	1.4
Condit. Reinf. active minus inactive responses	2.3	2.9	3.3	-1.8	1.7	1.5	-1.8
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.1	-1.3	1.2	1.8	-1.6
Condit. Reinf. active responses	1.9	2.6	3.1	-1.6	1.6	1.4	-1.8
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.1	-0.0	-0.6	-0.0
Condit. Reinf. lever presses	2.4	3.3	3.9	-2.0	1.9	1.5	-1.9
Condit. Reinf. lever reinforcers received	2.1	3.0	3.5	-1.8	1.8	1.4	-1.9
Conditioned reinforcement - actives	0.3	0.3	0.9	0.3	-0.3	-1.0	0.3
Conditioned reinforcement - inactives	0.7	0.8	1.3	1.0	-1.0	-1.1	0.2
Conditioned locomotion	0.5	0.6	0.9	0.6	-0.6	-0.8	0.9
Patch foraging indifference point 0 sec	0.9	1.5	2.1	-1.5	1.4	1.0	-0.9
Patch foraging indifference point AUC	0.1	0.2	0.3	-0.4	0.2	-0.4	0.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.1	-0.2	0.2	0.2
Delay disc. indifference point, 16s delay	1.2	1.2	1.7	1.0	-1.0	-0.9	1.3
Delay disc. indifference point, 2s delay	0.4	0.4	0.5	0.6	-0.6	-0.6	0.7
Delay disc. indifference point, 24s delay	1.1	1.0	1.2	1.0	-1.0	-1.0	1.1
Delay disc. indifference point, 4s delay	2.4	2.5	2.8	1.5	-1.6	-1.6	1.7
Delay disc. indifference point, 8s delay	2.2	2.3	3.2	1.5	-1.5	-1.2	1.8
Indifference point function ln k	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Indifference point function log k	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Patch foraging total patch changes 0 sec	1.2	2.0	2.5	-1.6	1.6	1.2	-1.2
Patch foraging total patch changes 12 sec	0.5	0.6	1.1	-1.0	1.0	-0.2	-0.6
Patch foraging total patch changes 18 sec	2.2	2.9	4.4	-2.1	2.1	0.9	-1.4
Patch foraging total patch changes 24 sec	2.5	3.1	3.9	-2.0	1.9	1.3	-1.7
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.4	0.3	-0.1	0.3
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.7	-0.6	-0.3	0.1
Patch foraging water rate 0 sec	0.2	0.4	0.5	-0.7	0.7	-0.0	-0.7
Patch foraging water rate 12 sec	0.4	0.6	0.8	-0.7	0.6	0.9	-0.8
Patch foraging water rate 18 sec	0.4	0.5	1.5	-0.2	0.1	1.2	-0.7
Patch foraging water rate 24 sec	0.7	1.0	1.3	-0.9	0.9	1.2	-1.0
Patch foraging water rate 6 sec	0.3	0.4	0.6	-0.8	0.7	0.3	-0.5
Seeking ratio, delayed vs. immediate footshock	2.1	2.4	3.5	1.6	-1.7	-0.7	1.9
Distance traveled before self-admin	0.2	0.2	0.7	-0.2	0.1	0.5	-0.8
Distance traveled after self-admin	0.3	0.3	0.8	0.5	-0.4	-0.9	0.2
Extensor digitorum longus weight	0.1	0.4	0.7	0.8	-0.8	-0.2	0.3
Bone: elastic displacement	0.2	0.2	0.5	-0.3	0.3	-0.3	-0.7
Bone: elastic work	0.7	1.0	1.7	-1.0	1.0	0.2	-1.3
Bone: endosteal estimation	0.2	0.4	0.9	-0.5	0.5	1.0	-0.3
Bone: endosteal perimeter	0.9	1.9	2.3	1.5	-1.5	-0.9	1.4
Epididymis fat weight	0.4	0.9	1.8	-0.8	0.8	1.3	-0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	0.3	-0.3	0.5	0.5
Delta time in open arm before/after self-admin	0.3	0.3	0.4	-0.6	0.6	-0.7	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.2	-0.1	-0.1	-0.5
Delay discount exponential model param	2.8	2.9	3.8	-1.7	1.7	1.5	-1.9
Extinction: sum of active levers before priming	0.1	0.1	0.4	-0.3	0.2	0.6	0.2
Active lever presses in extinction session 6	0.5	0.5	1.2	-0.6	0.6	1.1	-0.2
Bone: final force	0.9	1.5	2.2	-1.2	1.2	1.0	-1.5
Bone: final moment	1.2	2.0	3.0	-1.4	1.3	1.2	-1.7
Food consumed during 24 hour testing period	1.7	2.0	2.5	-1.3	1.3	1.6	-1.5
Glucose	0.2	0.3	0.5	-0.6	0.5	0.7	0.0
Heart weight	2.3	3.2	5.2	-1.7	1.7	1.4	-2.3
Delay discount hyperbolic model param	2.8	3.0	3.8	-1.7	1.7	1.6	-2.0
Intermittent access intake day 1-15 change	0.4	0.4	0.6	0.7	-0.7	-0.8	-0.2
Intermittent access intake escalation	0.3	0.3	0.5	0.5	-0.5	-0.7	-0.2
Intermittent access intake escalation 2	0.3	0.3	1.1	-0.1	0.2	-0.3	-1.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.2	0.0	0.0
Intermitt. access day 15 inactive lever presses	0.6	0.6	0.9	1.0	-1.0	-0.8	0.3
Intermitt. access escalation Index	0.2	0.1	0.4	-0.1	0.0	0.6	0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	0.0	0.0	0.2
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.0
Intermittent access total infusions	0.1	0.2	0.2	0.4	-0.4	-0.3	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5
Intermittent access day 15 total locomotion	0.6	0.6	0.9	0.7	-0.7	-0.7	0.9
Intermittent access total locomotion	1.1	1.3	1.8	1.1	-1.1	-0.9	1.4
Intermittent access standard deviation	0.6	0.7	2.0	-0.5	0.5	-0.5	-1.4
Left kidney weight	0.5	1.5	3.0	-1.3	1.2	1.7	-0.3
Right kidney weight	0.2	0.7	2.0	-0.6	0.6	1.4	0.2
Cocaine induced anxiety	0.5	0.6	0.8	0.9	-0.9	-0.8	0.4
Post-drug Anxiety	0.4	0.4	0.6	0.7	-0.8	-0.6	0.4
Baseline Anxiety	0.2	0.2	0.3	0.4	-0.4	-0.3	0.5
Tail length	5.9	18.0	20.9	-4.6	4.6	3.7	-4.1
Length with tail	8.8	32.3	35.7	-6.0	6.0	5.2	-5.6
Length without tail	6.8	14.9	15.6	-3.9	3.9	3.7	-3.8
Times rat made contact with spout	0.4	0.5	0.8	-0.5	0.5	0.9	-0.7
Lifetime Intake	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4
Liver weight, left	0.1	0.1	0.4	-0.1	0.1	0.2	0.6
Liver weight, right	1.0	1.6	2.3	-1.4	1.3	1.5	-0.8
Locomotor activity	5.9	9.4	11.2	-3.2	3.3	2.4	-3.2
Locomotor testing distance	5.6	9.3	11.0	-3.2	3.3	2.5	-3.2
Locomotor testing rearing	0.4	0.6	0.8	-0.7	0.8	0.5	-0.9
Locomotion in novel chamber	0.1	0.1	0.3	0.3	-0.4	-0.5	0.0
Locomotion in novel chamber post-restriction	0.5	0.7	1.1	-1.0	1.0	0.4	-0.6
Fecal boli incidents, locomotor time 1	0.5	0.6	0.7	-0.8	0.7	0.7	-0.8
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	0.3	0.2	0.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.4	-0.5	-0.2	0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2
Rest time, locomotor task time 1	0.5	0.5	0.7	0.7	-0.8	-0.5	0.8
Distance moved, locomotor task time 1	1.7	1.9	2.4	-1.3	1.4	1.1	-1.5
Vertical activity count, locomotor time 1	0.6	0.6	0.8	-0.8	0.9	0.6	-0.8
Time >=10cm from walls, locomotor time 2	1.5	1.6	1.8	-1.3	1.3	1.3	-1.1
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.3	0.4	0.3	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	0.1	0.0	-0.2
Rest time, locomotor task time 2	0.0	0.1	0.2	0.0	0.0	-0.4	0.3
Distance moved, locomotor task time 2	0.8	0.9	1.3	-0.8	0.8	1.1	-1.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	0.0	0.3	-0.2
Light reinforcement 1	0.5	0.9	1.0	-1.0	1.0	1.0	-0.8
Light reinforcement 2	0.3	0.4	1.0	0.5	-0.5	0.3	1.0
Bone: marrow area	0.2	0.4	1.0	-0.5	0.5	1.0	-0.3
Bone: maximum diameter	0.3	0.5	0.7	0.8	-0.8	-0.8	0.4
Bone: maximum force	0.8	1.4	1.6	-1.2	1.2	1.1	-1.3
Bone: maximum moment	1.0	1.7	2.0	-1.2	1.2	1.2	-1.4
Mean time between licks in bursts	0.8	1.1	1.4	1.2	-1.2	-1.0	0.7
Mean num. licks in bursts	0.4	0.4	0.6	-0.8	0.7	0.7	-0.3
Cd content in liver	2.4	2.7	3.6	-1.6	1.6	1.4	-1.9
Co content in liver	0.1	0.1	0.3	-0.2	0.3	0.4	-0.6
Cu content in liver	4.0	4.9	5.4	-2.3	2.3	2.1	-2.0
Fe content in liver	1.7	2.0	2.5	-1.4	1.5	1.0	-1.6
K content in liver	0.6	0.6	1.0	-1.0	0.9	0.3	-0.5
Mg content in liver	0.0	0.0	0.1	-0.2	0.2	-0.3	0.1
Mn content in liver	0.6	0.6	1.2	-1.1	1.0	0.4	-0.4
Na content in liver	0.3	0.3	0.4	-0.6	0.7	-0.6	-0.3
Rb content in liver	1.2	1.5	2.5	-1.1	1.2	0.9	-1.6
Se content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.0
Sr content in liver	0.1	0.1	0.2	-0.1	0.1	0.5	0.1
Zn content in liver	5.2	5.8	7.6	-2.4	2.4	2.8	-1.9
Bone: minimum diameter	0.2	0.4	0.6	0.7	-0.7	-0.3	0.5
Time in familiar zone, hab. session 1	1.1	1.0	1.5	1.1	-1.0	-1.2	0.5
Time in novel zone, hab. session 1	0.5	0.5	1.0	-0.5	0.5	1.0	-0.5
Total zone transitions, hab. session 1	0.7	1.0	2.1	-0.9	0.9	1.5	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.7	-0.6	0.5	0.8	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.7	0.6	0.7	-0.1
Time in familiar zone, hab. session 2	0.4	0.4	1.0	0.5	-0.4	-1.0	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.0	0.0	0.5	0.1
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.3	0.2	0.6	0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.6	0.6	0.3	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.5	0.4	0.1	0.0
Novel to familiar place preference ratio	0.7	0.8	1.1	-1.0	1.0	1.0	0.1
Novelty place preference	0.7	0.7	1.1	-1.0	0.9	1.0	0.1
Time in novel zone, NPP test	0.9	1.0	1.5	-1.1	1.1	1.2	-0.1
Total zone transitions, NPP test	2.3	3.3	5.1	-1.9	1.8	2.2	-1.1
Total locomotion distance, NPP test	0.9	1.2	1.4	-1.2	1.1	1.2	-0.8
Locomotion velocity, NPP test	0.9	1.3	1.7	-1.3	1.2	1.2	-0.7
Intraocular pressure	1.0	1.4	1.9	-1.1	1.2	1.4	-1.0
Delta distance traveled before/after self-admin	0.5	0.5	1.0	0.5	-0.4	-1.0	0.8
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.4	0.6	-0.1	-0.0
Parametrial fat weight	0.7	1.4	1.6	-1.3	1.3	1.2	-0.9
Pavlov. Cond. lever latency	4.8	6.1	6.2	-2.4	2.5	2.5	-2.5
Pavlov. Cond. magazine entry latency	6.4	8.3	10.9	2.8	-2.8	-3.3	2.5
Pavlov. Cond. change in total contacts	1.7	1.8	3.2	1.1	-1.1	-1.8	1.2
Pavlov. Cond. index score	6.3	7.9	10.2	2.7	-2.8	-3.2	2.5
Pavlov. Cond. latency score	6.1	7.7	9.4	2.7	-2.7	-3.1	2.6
Pavlov. Cond. lever contacts	2.8	3.3	3.5	1.8	-1.8	-1.8	1.9
Pavlov. Cond. magazine entry number	7.4	9.3	11.8	-3.0	3.0	3.4	-2.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	-0.7	0.7	0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	5.5	6.9	9.4	2.6	-2.6	-3.1	2.2
Pavlov. Cond. response bias	6.8	8.3	10.4	2.9	-2.9	-3.2	2.5
Pavlov. Cond. lever latency	0.5	0.7	0.9	1.0	-0.9	-0.6	0.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.1	-0.2	-0.8	0.1
Pavlov. Cond. change in total contacts	2.6	3.5	4.4	-2.1	2.0	1.3	-2.1
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.4	-0.1	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.5
Pavlov. Cond. lever contacts	1.0	1.4	1.8	-1.3	1.2	1.0	-1.1
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	-0.4	0.5	1.0	-0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.7	-0.6	-0.5	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.5	0.4	-0.1	-0.6
Pavlov. Cond. response bias	0.1	0.2	0.2	-0.5	0.4	0.1	-0.5
Time in closed arm before self-admin	1.9	2.1	2.7	-1.5	1.5	1.1	-1.7
Time in closed arm after self-admin	0.2	0.2	0.6	-0.2	0.2	0.8	-0.3
Time in open arm before self-admin	1.1	1.2	1.7	1.3	-1.3	-0.5	1.1
Time in open arm after self-admin	0.8	0.9	1.8	0.4	-0.4	-1.3	1.2
Bone: periosteal estimation	0.1	0.1	0.2	-0.3	0.2	0.4	-0.4
Bone: periosteal perimeter	0.9	1.5	1.8	1.3	-1.3	-1.1	1.1
Bone: post-yield work	0.1	0.2	0.6	-0.2	0.2	0.8	-0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.1	-0.0	0.0	0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	0.0	-0.2	0.1	0.4
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.0	0.6	-0.7	-1.0	0.1
Progressive ratio test 2 active lever presses	0.7	0.8	0.9	0.9	-0.9	-0.9	0.8
Progressive ratio test 2 breakpoint	0.5	0.6	0.7	0.8	-0.8	-0.7	0.7
Progressive ratio test 2 inactive lever presses	1.5	1.7	2.4	1.4	-1.5	-1.5	0.6
Incentive Sensitization - Responses	1.5	1.5	2.0	1.4	-1.3	-1.2	0.9
Incentive Sensitization - Breakpoint	1.4	1.4	1.9	1.4	-1.3	-1.2	0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.6	0.6	0.3	-0.3
Progressive ratio	3.4	4.0	4.6	-2.1	2.2	1.9	-1.7
Food seeking constrained by brief footshock	0.4	0.5	0.8	0.9	-0.9	-0.2	0.7
Seeking ratio, punishment vs. effort	4.6	5.6	7.1	2.7	-2.7	-1.9	2.1
Retroperitoneal fat weight	0.6	1.9	2.8	-1.4	1.4	1.7	-0.9
Reaction time number correct	0.2	0.3	0.5	0.7	-0.6	-0.3	0.4
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.0	0.1	0.1
Reaction time mean minus median AUC	0.1	0.1	0.3	-0.4	0.3	0.6	-0.2
Reaction time num false alarms	0.3	0.4	0.5	0.6	-0.5	-0.5	0.7
Reaction time num false alarms AUC	0.1	0.1	0.3	0.3	-0.2	-0.2	0.6
Reaction time trials correct on left	0.2	0.3	0.5	0.7	-0.6	-0.3	0.4
Reaction time trials on left	0.2	0.3	0.6	0.8	-0.6	-0.3	0.5
Reaction time mean	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1
Median of all reaction times	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.1
Reaction time omissions	0.4	0.6	0.7	0.8	-0.8	-0.8	0.6
Reaction time false alarm rate	0.1	0.1	0.2	0.2	-0.1	-0.2	0.4
Reaction time premature initiation rate	1.2	1.6	2.4	-1.5	1.5	0.6	-1.3
Reaction time premature initiations	0.5	0.8	1.2	-0.9	1.1	0.5	-0.9
Std. dev. reaction times	0.0	0.1	0.1	-0.3	0.3	0.3	-0.0
Reaction time trials completed	0.2	0.3	0.6	0.8	-0.6	-0.3	0.5
Reaction time trials AUC	0.3	0.4	0.7	0.8	-0.7	-0.4	0.5
Run reversals in cocaine runway, females	1.6	1.6	2.1	1.5	-1.4	-1.0	1.1
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.5	0.5	-0.5	-0.8
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.5	0.5	-0.2	-0.6
Latency to leave start box in cocaine runway, F	1.2	1.3	2.7	-1.1	1.1	0.2	-1.6
Latency to leave start box in cocaine runway, M	0.6	0.6	1.3	0.6	-0.5	-0.6	1.2
Std. dev. time between licks in bursts	2.4	2.9	4.0	2.0	-2.0	-1.5	1.1
Total sessions with >9 infusions	0.1	0.1	0.2	0.2	-0.1	0.3	-0.5
Short access day 1 total inactive lever presses	2.2	2.4	3.1	1.8	-1.7	-1.5	1.3
Short access day 10 total inactive lever presses	0.1	0.2	0.2	0.3	-0.2	-0.5	-0.5
Short access day 1 total infusions	0.7	0.7	0.9	1.0	-0.9	-0.8	0.7
Short access day 10 total infusions	0.0	0.1	0.2	-0.1	0.0	0.4	0.1
Short access total infusions	0.3	0.4	0.5	0.6	-0.6	-0.4	0.7
Short access day 1 locomotion	0.1	0.1	0.1	0.2	-0.2	0.3	0.2
Short access day 10 total locomotion	0.1	0.1	0.2	-0.3	0.2	0.5	0.3
Short access total locomotion	0.1	0.1	0.3	0.1	-0.1	0.2	0.5
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.2	-0.3	-0.3	0.4
Compulsive drug intake	0.1	0.1	0.4	0.1	-0.2	0.2	0.6
One hour access (shock baseline)	0.1	0.1	0.4	0.0	-0.1	-0.6	-0.2
Social response proportion	0.1	0.1	0.3	-0.4	0.5	0.1	-0.3
Social responses	0.3	0.3	0.5	-0.6	0.6	0.7	-0.2
Social time	0.7	0.9	1.4	1.2	-1.1	-0.9	0.2
Soleus weight	4.3	12.6	15.4	-3.4	3.4	3.9	-3.4
Bone: stiffness	0.1	0.2	0.3	-0.4	0.4	0.5	-0.3
Tibialis anterior weight	0.1	0.4	1.1	-0.2	0.2	1.1	-0.5
Time to tail flick, vehicle, before self-admin	2.1	2.1	2.9	-1.4	1.3	1.7	-1.4
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.0	-0.7	0.7	-0.2	-1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.2	-0.3	0.4	0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.4	-0.3	0.1
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	2.4	0.7	-0.6	-1.5	0.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	-0.1	-0.4	-0.1
Tibia length	6.8	19.3	21.0	-4.6	4.5	4.3	-4.2
Ambulatory time before self-admin	0.1	0.1	0.3	0.1	-0.2	0.3	-0.5
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	-0.1	-0.4	0.2
Bone: tissue strength	3.6	3.5	4.7	-1.9	1.9	1.4	-2.2
Total heroin consumption	1.1	1.3	2.0	-1.2	1.2	0.6	-1.4
Bone: trabecular number	0.7	1.1	1.8	0.8	-0.9	-1.1	1.3
Bone: trabecular spacing	1.4	1.8	2.6	-1.2	1.3	1.2	-1.6
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	0.2	-0.4	0.4
Bone: trabecular tissue density	0.1	0.2	0.3	-0.5	0.5	0.6	-0.2
Water consumed over 24 hours	0.1	0.1	0.2	0.1	-0.1	0.5	-0.5
Number of responses in last shaping day	0.3	0.3	0.7	0.7	-0.8	-0.2	0.2