Hub : Genes

Epb41l4a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Epb41l4a 0.11 0.07 1.5e-05 0.03 0.04 0.03 0.03 2.4e-04 1.9e-05 1.0e-04 1.1e-04
2 LHb gene expression Epb41l4a 0.36 0.23 1.3e-04 0.19 0.17 0.23 0.22 2.6e-05 7.6e-05 2.7e-06 5.9e-06
3 Brain gene expression Epb41l4a 0.45 0.07 0.0e+00 0.38 0.35 0.48 0.48 3.1e-37 2.2e-33 1.0e-49 2.3e-50
4 BLA gene expression Epb41l4a 0.14 0.07 3.1e-03 0.04 0.05 0.05 0.04 2.2e-03 1.2e-03 8.6e-04 2.9e-03
5 PL gene expression Epb41l4a 0.23 0.04 0.0e+00 0.22 0.24 0.23 0.23 2.0e-23 1.2e-25 3.0e-25 1.3e-24
6 Adipose gene expression Epb41l4a 0.67 0 0.0e+00 0.18 0.16 0.16 0.16 2.2e-19 2.3e-17 1.5e-17 7.6e-18
7 IL gene expression Epb41l4a 0.46 0.18 2.4e-05 0.23 0.17 0.23 0.18 2.5e-06 5.8e-05 3.8e-06 3.9e-05
8 OFC gene expression Epb41l4a 0.38 0.18 9.5e-04 0.01 0.03 0.01 0.02 2.0e-01 6.2e-02 1.9e-01 9.8e-02
9 Liver alternative TSS NM_001107397.2 0.06 0.04 8.3e-04 0.02 0.02 0.01 0.02 2.5e-03 3.8e-03 2.0e-02 3.3e-03
10 Liver alternative TSS NM_001107397.2 0.06 0.04 1.1e-03 0.02 0.02 0.01 0.02 3.1e-03 5.5e-03 2.4e-02 4.3e-03
11 Liver gene expression Epb41l4a 0.16 0.08 3.6e-09 0.07 0.08 0.07 0.08 5.7e-08 4.6e-09 1.7e-08 6.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.40.72.2-0.60.2-0.81.1-0.9-1.51.2-0.7-0.2-0.2-0.1
Area under the delay curve1.21.33.6-0.1-0.8-0.3-0.4-0.4-0.70.61.31.91.91.9
BMI with tail4.314.034.85.9-2.84.7-4.74.54.0-4.03.60.50.51.3
BMI without tail5.010.420.34.5-3.44.0-4.13.93.3-3.43.20.60.61.1
Body weight3.012.736.36.0-2.14.5-4.34.43.9-3.83.10.40.40.9
Weight adjusted by age0.70.72.01.40.11.0-0.81.00.7-0.71.20.60.60.5
Bone surface1.01.73.1-1.21.1-1.61.8-1.6-1.61.5-1.5-0.5-0.5-0.3
Bone volume0.91.52.9-1.10.8-1.41.7-1.3-1.61.5-1.5-0.5-0.5-0.5
Breakpoint value in progressive ratio session0.10.10.2-0.3-0.0-0.0-0.2-0.00.1-0.1-0.2-0.5-0.5-0.4
Number of licking bursts2.02.44.2-1.61.7-1.91.8-1.8-1.92.1-1.7-0.2-0.2-0.4
Context. condit. distance diff. score0.60.72.21.0-1.51.0-1.00.90.5-0.40.90.30.30.7
Locomotion velocity, session 12.02.16.0-1.20.5-0.61.1-0.10.1-0.1-2.2-2.2-2.2-2.5
Locomotion distance, session 10.10.10.4-0.2-0.6-0.10.10.20.1-0.0-0.5-0.4-0.4-0.7
Locomotion velocity, session 20.20.21.00.01.0-0.30.3-0.10.4-0.3-0.6-0.2-0.2-0.6
Locomotion distance, session 20.50.71.5-1.10.6-1.21.0-1.0-0.60.7-1.00.30.3-0.4
Locomotion velocity, session 30.80.92.81.0-1.70.9-1.11.21.3-1.10.40.10.1-0.2
Locomotion distance, session 30.50.61.60.8-1.30.6-0.80.60.4-0.30.80.90.90.7
Stereotopy head waving bouts, day 31.31.52.8-1.61.3-1.71.5-1.6-1.11.5-0.70.70.70.2
Stereotopy head waving duration, day 30.10.10.2-0.50.1-0.20.1-0.10.30.10.20.50.50.0
Locomotion velocity, session 70.40.40.90.90.70.2-0.50.00.1-0.30.60.90.90.8
Locomotion distance, session 70.70.92.70.60.4-0.4-0.1-0.5-0.50.31.01.61.61.6
Stereotopy head waving bouts, day 70.10.10.30.2-0.00.6-0.20.50.00.00.5-0.2-0.2-0.2
Stereotopy head waving duration, day 70.00.00.1-0.20.10.3-0.00.2-0.10.20.1-0.3-0.3-0.3
Locomotion velocity, session 80.60.71.60.4-1.00.9-1.11.11.3-1.00.3-0.2-0.2-0.5
Locomotion distance, session 80.30.42.20.4-1.50.5-0.70.70.7-0.50.20.10.1-0.1
Degree of sensitization distance0.40.41.40.51.2-0.3-0.0-0.5-0.20.20.70.80.81.0
Degree of sensitization stereotypy0.10.10.3-0.30.30.30.20.2-0.50.5-0.0-0.4-0.4-0.4
Conditioned locomotion0.10.20.40.60.3-0.0-0.1-0.0-0.20.30.20.60.60.6
Cocaine response after cond. corrected1.71.93.41.1-1.71.5-1.51.61.8-1.80.0-1.2-1.2-0.7
Cocaine response after cond. not corrected0.60.71.30.0-0.90.5-0.60.71.1-1.0-0.6-1.2-1.2-0.8
Cocaine response before conditioning3.64.37.6-2.52.3-2.72.5-2.7-2.42.5-1.20.90.90.5
Saline control response0.91.22.0-1.31.2-1.41.4-1.4-1.21.2-0.80.20.2-0.0
Bone: connectivity density1.21.94.3-1.50.6-1.51.7-1.5-2.11.8-1.3-0.7-0.7-0.2
Bone: cortical apparent density1.11.42.7-1.71.4-1.41.6-1.4-1.31.4-0.80.30.3-0.2
Bone: cortical area1.92.95.6-1.61.8-2.32.0-2.3-1.92.4-0.80.90.90.8
Bone: cortical porosity0.50.61.20.3-0.30.5-0.50.81.1-0.9-0.4-1.0-1.0-1.0
Bone: cortical porosity0.50.51.30.3-0.20.5-0.60.71.1-0.9-0.3-0.9-0.9-0.8
Bone: cortical thickness1.83.05.7-0.81.8-1.81.4-2.0-2.12.40.21.71.71.8
Bone: cortical thickness0.30.41.00.20.4-0.40.0-0.5-0.60.60.40.90.91.0
Bone: cortical tissue density1.01.32.7-1.61.3-1.41.5-1.3-1.21.3-0.90.20.2-0.4
Condit. Reinf. active minus inactive responses1.01.12.3-1.5-0.1-1.31.4-1.1-1.41.2-1.00.10.1-0.3
Condit. Reinf. active-inactive response ratio0.70.82.0-0.2-0.4-0.60.4-0.6-0.90.90.61.41.41.1
Condit. Reinf. active responses2.32.96.9-2.3-0.4-1.72.0-1.2-1.31.1-2.6-1.5-1.5-1.9
Condit. Reinf. inactive responses3.23.810.2-2.40.4-1.82.0-1.3-1.00.9-3.2-2.1-2.1-2.4
Incentive salience index mean1.51.84.4-2.10.2-1.61.8-1.2-1.41.3-1.6-0.8-0.8-1.0
Condit. Reinf. lever presses1.11.53.7-1.90.3-1.41.6-1.2-1.21.1-1.4-0.9-0.9-0.9
Condit. Reinf. active minus inactive responses2.53.18.7-3.00.6-1.91.8-1.6-1.00.9-2.5-1.7-1.7-1.7
Condit. Reinf. active-inactive response ratio1.41.44.6-0.9-0.60.1-0.20.40.8-0.9-1.2-2.1-2.1-1.6
Condit. Reinf. active responses4.36.017.1-4.11.4-3.12.9-2.7-2.22.1-2.8-1.0-1.0-1.3
Condit. Reinf. inactive responses5.06.213.0-3.61.8-3.23.2-3.1-2.92.9-2.10.50.5-0.3
Condit. Reinf. lever presses2.02.86.4-2.51.3-2.12.0-1.9-1.11.0-2.3-0.9-0.9-1.2
Condit. Reinf. lever reinforcers received4.05.716.6-4.11.3-3.02.8-2.6-2.12.0-2.8-1.1-1.1-1.4
Conditioned reinforcement - actives0.80.82.0-0.6-1.10.3-0.20.60.7-0.7-0.8-1.4-1.4-1.3
Conditioned reinforcement - inactives0.00.10.30.2-0.60.20.40.10.1-0.1-0.10.00.00.0
Conditioned locomotion0.70.81.8-1.2-0.3-0.50.7-0.2-0.10.1-1.3-1.3-1.3-1.3
Patch foraging indifference point 0 sec0.61.02.1-1.50.1-1.21.0-1.3-1.31.3-0.20.80.80.5
Patch foraging indifference point AUC2.73.14.9-2.22.2-2.21.8-2.2-2.22.1-1.50.20.2-0.0
Delay disc. indifference point, 0s delay0.80.92.50.3-0.3-0.1-0.3-0.3-0.50.41.11.61.61.6
Delay disc. indifference point, 16s delay1.71.73.9-0.70.2-1.00.5-1.3-1.41.30.82.02.01.8
Delay disc. indifference point, 2s delay0.60.71.80.4-0.30.2-0.80.1-0.10.01.21.31.31.3
Delay disc. indifference point, 24s delay1.11.12.60.8-1.60.9-1.40.70.4-0.31.40.90.91.2
Delay disc. indifference point, 4s delay0.20.20.5-0.1-0.3-0.1-0.0-0.2-0.10.10.60.70.70.7
Delay disc. indifference point, 8s delay1.51.53.9-0.0-1.3-0.1-0.7-0.2-0.60.61.51.91.92.0
Indifference point function ln k5.07.011.83.4-2.83.4-2.93.33.2-3.42.1-0.3-0.3-0.0
Indifference point function log k5.07.011.83.4-2.83.4-2.93.33.2-3.42.1-0.3-0.3-0.0
Patch foraging total patch changes 0 sec0.71.12.5-1.60.2-1.41.1-1.4-1.41.4-0.60.60.60.3
Patch foraging total patch changes 12 sec5.06.410.8-3.22.2-3.32.9-3.2-3.23.3-1.90.80.80.3
Patch foraging total patch changes 18 sec1.92.54.9-1.91.0-2.01.5-2.1-2.22.2-1.10.60.60.5
Patch foraging total patch changes 24 sec1.51.83.3-1.41.1-1.71.4-1.8-1.71.8-0.41.01.00.9
Patch foraging total patch changes 6 sec1.52.34.1-2.00.9-2.01.7-2.0-1.91.9-1.00.50.50.4
Patch foraging time to switch 0 sec0.40.61.50.6-1.00.8-0.80.71.2-1.00.6-0.2-0.20.1
Patch foraging water rate 0 sec0.10.10.20.4-0.40.1-0.10.2-0.30.10.10.50.50.2
Patch foraging water rate 12 sec0.40.71.91.4-0.90.9-0.90.81.0-1.00.5-0.1-0.10.3
Patch foraging water rate 18 sec0.60.81.30.1-1.10.6-0.50.91.0-1.1-0.4-1.1-1.1-0.9
Patch foraging water rate 24 sec1.21.74.50.2-2.10.7-0.51.10.9-1.1-1.1-1.8-1.8-1.6
Patch foraging water rate 6 sec0.20.30.80.3-0.90.3-0.20.40.6-0.6-0.5-0.6-0.6-0.6
Seeking ratio, delayed vs. immediate footshock2.32.65.1-2.31.8-1.91.9-1.6-1.51.5-1.9-0.8-0.8-1.2
Distance traveled before self-admin0.60.72.40.5-0.50.7-0.80.50.4-0.41.60.90.91.1
Distance traveled after self-admin1.31.46.9-0.9-2.60.4-0.10.80.9-0.9-0.7-1.3-1.3-1.3
Extensor digitorum longus weight1.24.810.53.2-1.12.8-2.72.52.5-2.52.40.40.40.9
Bone: elastic displacement1.31.52.61.2-1.31.6-1.51.61.6-1.60.7-0.5-0.5-0.4
Bone: elastic work1.01.42.71.1-1.11.5-1.31.61.4-1.60.5-0.6-0.6-0.6
Bone: endosteal estimation0.51.12.2-1.40.9-1.41.4-1.2-0.50.7-1.5-0.4-0.4-0.7
Bone: endosteal perimeter0.10.30.5-0.70.7-0.70.5-0.60.30.1-0.6-0.6-0.6-0.2
Epididymis fat weight2.55.910.42.4-2.23.0-2.53.23.0-3.00.7-1.9-1.9-1.5
Delta time in closed arm before/after self-admin1.41.32.20.4-0.31.1-0.71.31.4-1.4-0.2-1.5-1.5-1.5
Delta time in open arm before/after self-admin3.73.57.9-0.32.8-1.71.7-2.1-2.22.20.12.02.01.7
Diff in mean of infusions in LGA sessions1.82.04.10.8-2.01.4-1.31.71.7-1.7-0.2-1.4-1.4-1.2
Delay discount exponential model param1.21.23.30.20.60.40.20.50.8-0.7-1.2-1.8-1.8-1.8
Extinction: sum of active levers before priming0.10.10.3-0.20.00.00.20.00.2-0.2-0.3-0.6-0.6-0.5
Active lever presses in extinction session 61.01.02.0-1.30.3-1.31.4-1.3-1.21.2-0.90.20.20.0
Bone: final force0.81.42.8-1.21.1-1.51.5-1.5-1.51.7-0.60.30.30.4
Bone: final moment0.60.91.7-1.10.9-1.31.3-1.2-1.01.3-0.8-0.0-0.0-0.0
Food consumed during 24 hour testing period0.30.41.81.40.00.9-0.70.90.3-0.30.30.20.20.1
Glucose3.75.611.92.7-1.72.8-2.72.93.5-3.20.9-1.6-1.6-0.9
Heart weight1.01.45.62.40.61.2-1.40.91.0-0.91.30.70.71.0
Delay discount hyperbolic model param1.01.02.80.30.50.40.20.60.8-0.7-1.0-1.7-1.7-1.7
Intermittent access intake day 1-15 change0.10.10.50.40.70.00.3-0.1-0.10.10.00.20.20.1
Intermittent access intake escalation0.10.10.30.30.5-0.10.5-0.2-0.30.2-0.10.20.20.1
Intermittent access intake escalation 20.20.20.60.50.8-0.0-0.0-0.2-0.30.30.40.60.60.6
Intermitt. access day 1 inactive lever presses1.11.22.7-1.01.2-1.11.6-0.9-0.60.7-1.6-0.9-0.9-1.2
Intermitt. access day 15 inactive lever presses0.20.20.70.2-0.90.2-0.10.30.3-0.3-0.5-0.5-0.5-0.6
Intermitt. access escalation Index0.50.51.2-0.10.8-0.10.50.10.3-0.3-0.9-1.0-1.0-1.1
Intermittent access day 1 total infusions1.51.73.8-1.5-1.0-0.40.6-0.00.3-0.3-1.8-2.0-2.0-2.0
Intermittent access day 15 total infusions1.11.22.8-1.0-1.0-0.20.60.10.3-0.3-1.6-1.7-1.7-1.7
Intermittent access terminal intake (last 3 days)0.30.40.9-0.6-0.7-0.10.3-0.00.2-0.2-0.8-0.9-0.9-0.9
Intermittent access total infusions1.61.74.3-1.0-1.40.10.20.50.8-0.8-1.5-2.1-2.1-2.0
Intermittent access day 1 locomotion1.92.05.0-1.1-1.2-0.10.40.40.7-0.7-1.8-2.2-2.2-2.2
Intermittent access day 15 total locomotion1.71.94.80.1-0.70.6-0.10.91.2-1.2-1.5-2.2-2.2-2.1
Intermittent access total locomotion1.92.15.6-0.4-1.00.5-0.10.91.2-1.2-1.5-2.4-2.4-2.2
Intermittent access standard deviation0.40.40.9-0.70.9-0.50.7-0.4-0.20.2-0.7-0.7-0.7-0.7
Left kidney weight0.10.10.70.40.8-0.0-0.10.0-0.10.2-0.6-0.4-0.4-0.4
Right kidney weight0.20.52.90.21.7-0.50.4-0.6-0.60.6-0.60.20.20.1
Cocaine induced anxiety0.30.31.0-0.50.3-0.10.30.10.2-0.2-0.8-0.9-0.9-1.0
Post-drug Anxiety2.22.46.5-1.52.6-1.91.9-1.9-1.71.7-1.20.10.1-0.3
Baseline Anxiety1.61.73.1-0.41.8-1.20.9-1.6-1.61.60.31.41.41.3
Tail length0.20.61.80.8-1.30.8-0.90.90.8-0.80.50.20.20.0
Length with tail0.20.82.71.60.10.9-1.00.90.9-0.80.90.40.40.4
Length without tail0.10.21.80.81.30.1-0.10.10.2-0.00.1-0.1-0.10.1
Times rat made contact with spout0.60.72.21.2-1.50.8-1.00.80.8-0.70.50.30.30.4
Lifetime Intake2.12.45.3-0.8-2.00.6-0.31.01.3-1.3-1.3-2.3-2.3-2.1
Liver weight, left1.82.96.9-2.00.7-1.31.6-0.7-0.60.4-2.6-2.1-2.1-2.5
Liver weight, right0.71.23.0-1.7-0.2-1.21.3-0.9-0.80.9-1.4-0.9-0.9-1.0
Locomotor activity1.22.06.41.00.20.1-0.1-0.2-0.20.61.82.52.52.0
Locomotor testing distance0.40.72.40.60.20.00.1-0.1-0.10.31.11.61.61.2
Locomotor testing rearing0.30.51.0-0.50.4-0.90.8-1.0-0.50.9-0.00.80.80.7
Locomotion in novel chamber1.21.55.80.2-2.41.2-1.01.41.4-1.40.2-0.9-0.9-0.8
Locomotion in novel chamber post-restriction0.70.81.80.71.3-0.2-0.1-0.5-0.60.60.81.31.31.3
Fecal boli incidents, locomotor time 10.60.61.50.1-1.20.6-0.60.91.0-1.10.0-0.8-0.8-0.6
Change in fecal boli incidents, locomotor task0.60.61.2-0.3-1.00.5-0.10.80.8-0.7-0.5-1.0-1.0-1.1
Time >=10cm from walls, locomotor time 11.11.13.00.8-1.71.2-0.81.41.1-1.30.0-0.7-0.7-0.7
Bouts of movement, locomotor time 10.20.22.2-0.1-1.50.0-0.1-0.0-0.40.2-0.10.20.20.2
Total resting periods, locomotor time 10.20.32.60.0-1.60.2-0.30.3-0.20.10.00.20.20.2
Rest time, locomotor task time 10.20.30.90.8-1.00.6-0.30.70.5-0.40.10.00.00.0
Distance moved, locomotor task time 12.32.510.2-1.03.2-1.71.5-1.9-1.81.8-0.30.80.80.6
Vertical activity count, locomotor time 12.02.19.4-0.23.1-1.01.1-1.3-1.51.40.61.31.31.1
Time >=10cm from walls, locomotor time 20.70.71.41.20.60.9-0.91.01.1-1.20.3-0.6-0.6-0.6
Bouts of movement, locomotor time 20.10.10.4-0.2-0.1-0.20.5-0.4-0.60.30.10.30.30.3
Total resting periods, locomotor time 20.00.10.20.0-0.20.10.3-0.2-0.40.10.20.30.30.3
Rest time, locomotor task time 22.63.05.22.3-1.92.3-2.22.01.9-1.91.80.30.30.7
Distance moved, locomotor task time 23.23.712.5-0.93.5-2.11.7-2.2-2.32.2-0.21.41.41.0
Vertical activity count, locomotor time 23.23.510.6-1.03.3-1.92.0-2.1-2.32.1-0.11.41.40.9
Light reinforcement 10.20.30.5-0.7-0.6-0.60.3-0.6-0.50.7-0.10.70.70.6
Light reinforcement 20.71.02.3-0.9-0.0-0.80.6-1.0-1.31.50.51.01.01.2
Bone: marrow area0.40.91.9-1.20.8-1.41.3-1.1-0.50.7-1.3-0.2-0.2-0.5
Bone: maximum diameter1.63.06.3-2.31.5-2.52.3-2.2-1.52.0-1.8-0.0-0.0-0.3
Bone: maximum force0.40.81.4-0.71.1-1.11.0-1.1-1.11.2-0.30.40.40.4
Bone: maximum moment0.30.40.8-0.60.9-0.90.9-0.8-0.70.8-0.50.00.00.0
Mean time between licks in bursts0.00.10.50.70.00.0-0.0-0.10.3-0.2-0.2-0.1-0.10.1
Mean num. licks in bursts3.64.36.72.4-2.62.5-2.42.42.3-2.52.00.40.40.7
Cd content in liver0.30.40.9-0.6-0.2-0.20.3-0.10.3-0.2-0.9-0.9-0.9-0.9
Co content in liver1.01.12.9-0.80.5-0.50.9-0.2-0.50.1-1.7-1.5-1.5-1.7
Cu content in liver1.41.73.6-1.90.9-1.71.5-1.6-1.61.4-0.51.01.00.4
Fe content in liver1.31.53.0-0.61.1-1.31.0-1.4-1.51.70.31.41.41.2
K content in liver1.71.73.5-1.90.7-1.31.6-1.0-1.10.8-1.7-1.1-1.1-1.5
Mg content in liver1.41.43.6-1.9-0.3-1.21.5-0.9-1.20.8-1.6-0.7-0.7-1.2
Mn content in liver0.30.30.90.0-0.20.10.20.20.2-0.2-0.8-0.9-0.9-0.9
Na content in liver0.30.30.8-0.90.4-0.40.6-0.3-0.30.1-0.7-0.6-0.6-0.8
Rb content in liver3.44.27.4-2.41.4-2.42.7-2.3-2.52.2-2.5-0.7-0.7-1.1
Se content in liver1.01.22.7-0.81.6-1.21.3-1.4-1.41.4-0.60.60.60.3
Sr content in liver0.20.20.4-0.60.5-0.40.2-0.5-0.20.40.30.50.50.5
Zn content in liver0.80.91.8-1.30.3-1.11.1-1.1-1.31.3-0.40.40.40.3
Bone: minimum diameter0.71.32.7-1.41.3-1.61.6-1.5-0.91.1-1.2-0.0-0.0-0.1
Time in familiar zone, hab. session 10.20.20.40.60.30.4-0.10.2-0.60.40.20.40.40.3
Time in novel zone, hab. session 10.40.41.0-0.40.3-0.6-0.1-0.60.00.20.60.90.91.0
Total zone transitions, hab. session 11.21.64.60.0-0.30.5-0.00.80.8-0.9-1.3-2.1-2.1-2.1
Total locomotion distance, hab. session 11.62.35.8-1.4-0.4-0.50.9-0.10.0-0.2-2.1-2.4-2.4-2.4
Locomotion velocity, hab. session 12.43.38.9-1.6-0.8-0.50.90.10.3-0.5-2.5-3.0-3.0-2.9
Time in familiar zone, hab. session 21.51.54.50.0-0.8-0.40.2-0.6-1.41.20.72.12.11.6
Time in novel zone, hab. session 21.71.74.7-0.00.60.7-0.50.81.7-1.4-0.7-2.2-2.2-1.6
Total zone transitions, hab. session 20.20.20.80.1-0.90.2-0.40.40.4-0.4-0.3-0.6-0.6-0.6
Total locomotion distance, hab. session 20.50.62.3-0.6-1.5-0.20.10.10.1-0.1-0.9-1.1-1.1-0.9
Locomotion velocity, hab. session 20.70.93.1-0.5-1.7-0.0-0.00.40.4-0.4-1.0-1.4-1.4-1.2
Novel to familiar place preference ratio3.84.09.12.4-1.02.2-2.41.91.9-1.73.01.41.41.8
Novelty place preference4.14.29.42.5-0.92.3-2.42.02.0-1.93.11.41.41.8
Time in novel zone, NPP test4.04.19.42.5-0.72.2-2.51.82.0-1.83.11.51.51.9
Total zone transitions, NPP test1.52.25.3-1.60.7-1.21.3-0.8-0.40.7-2.3-1.9-1.9-2.0
Total locomotion distance, NPP test2.02.86.5-2.0-0.5-1.11.6-0.6-0.60.8-2.5-2.2-2.2-2.3
Locomotion velocity, NPP test2.12.96.7-2.1-0.5-1.31.7-0.8-0.70.9-2.6-2.1-2.1-2.3
Intraocular pressure2.83.99.93.1-0.82.2-2.52.12.5-2.31.90.60.60.8
Delta distance traveled before/after self-admin3.23.513.8-1.3-3.70.20.00.90.9-0.9-2.0-2.3-2.3-2.3
Delta ambulatory time before/after self-admin2.62.811.9-1.2-3.40.1-0.10.70.8-0.8-1.8-2.1-2.1-2.0
Parametrial fat weight1.83.46.31.1-2.52.2-2.22.32.3-2.41.0-1.2-1.2-0.6
Pavlov. Cond. lever latency1.31.63.31.3-0.90.9-1.50.61.1-0.81.81.51.51.6
Pavlov. Cond. magazine entry latency0.81.12.4-0.51.4-1.01.0-1.0-1.61.40.10.90.90.7
Pavlov. Cond. change in total contacts0.60.61.6-0.71.3-0.81.0-0.8-1.11.0-0.20.10.10.1
Pavlov. Cond. index score0.60.81.5-1.01.0-0.81.2-0.6-1.20.9-0.9-0.6-0.6-0.7
Pavlov. Cond. latency score0.50.61.1-0.90.7-0.61.0-0.4-0.90.6-0.9-0.8-0.8-0.9
Pavlov. Cond. lever contacts1.82.13.3-1.81.4-1.21.8-1.0-1.41.1-1.8-1.2-1.2-1.5
Pavlov. Cond. magazine entry number0.40.51.60.4-0.90.7-0.80.71.3-1.10.0-0.3-0.3-0.4
Pavlov. Cond. intertrial magazine entries1.51.84.9-1.50.5-1.21.4-0.9-0.50.4-2.2-1.7-1.7-1.7
Pavlov. Cond. lever-magazine prob. diff.0.60.81.6-1.01.0-0.91.3-0.7-1.20.9-0.9-0.4-0.4-0.6
Pavlov. Cond. response bias0.91.12.2-1.11.2-1.11.5-1.0-1.51.3-1.0-0.2-0.2-0.5
Pavlov. Cond. lever latency0.91.23.61.9-0.31.1-1.11.00.5-0.31.51.11.11.1
Pavlov. Cond. magazine entry latency0.30.31.0-0.8-0.1-0.30.5-0.1-0.0-0.0-1.0-0.7-0.7-0.9
Pavlov. Cond. change in total contacts1.21.65.1-2.31.1-1.61.5-1.6-0.80.8-1.4-0.6-0.6-0.7
Pavlov. Cond. index score0.91.23.1-1.80.5-1.11.2-0.9-0.50.3-1.6-1.0-1.0-1.2
Pavlov. Cond. latency score1.01.33.3-1.80.7-1.11.3-0.9-0.60.5-1.5-1.0-1.0-1.2
Pavlov. Cond. lever contacts1.21.74.1-2.00.2-1.21.3-1.0-0.40.2-2.0-1.4-1.4-1.4
Pavlov. Cond. magazine entry number0.70.82.41.5-0.51.1-1.21.00.8-0.71.00.20.20.6
Pavlov. Cond. intertrial magazine entries0.10.10.30.4-0.10.1-0.2-0.0-0.10.00.30.50.50.4
Pavlov. Cond. lever-magazine prob. diff.1.01.33.3-1.80.7-1.11.2-1.0-0.50.3-1.6-1.1-1.1-1.2
Pavlov. Cond. response bias1.21.64.7-2.20.5-1.51.4-1.3-0.80.6-1.7-1.0-1.0-1.0
Time in closed arm before self-admin0.30.41.51.20.40.5-0.40.30.2-0.20.60.70.70.7
Time in closed arm after self-admin0.40.40.80.80.10.8-0.90.80.8-0.80.4-0.2-0.2-0.1
Time in open arm before self-admin1.51.76.2-0.0-2.51.0-1.01.31.3-1.3-0.3-1.3-1.3-1.1
Time in open arm after self-admin1.92.14.6-0.82.1-1.71.9-1.8-1.71.7-1.00.60.60.2
Bone: periosteal estimation1.02.14.4-1.51.6-2.11.9-2.0-1.31.7-1.10.50.50.3
Bone: periosteal perimeter0.61.02.2-1.21.3-1.51.2-1.4-0.61.1-0.8-0.1-0.10.1
Bone: post-yield work0.30.30.8-0.70.4-0.70.9-0.6-0.90.7-0.5-0.0-0.0-0.1
Progressive ratio test 1 active lever presses1.71.84.1-0.5-1.60.4-0.30.91.0-1.0-1.3-2.0-2.0-1.9
Progressive ratio test 1 breakpoint1.71.84.0-0.5-1.70.5-0.41.01.1-1.1-1.2-2.0-2.0-1.9
Progressive ratio test 1 inactive lever presses1.21.32.9-0.9-1.40.00.40.40.5-0.5-1.4-1.7-1.7-1.7
Progressive ratio test 2 active lever presses3.13.37.7-0.7-2.20.7-0.21.11.5-1.5-1.7-2.8-2.8-2.6
Progressive ratio test 2 breakpoint2.83.17.8-0.7-1.80.6-0.21.01.4-1.4-1.7-2.8-2.8-2.6
Progressive ratio test 2 inactive lever presses2.83.38.5-1.5-0.6-0.41.00.20.6-0.6-2.6-2.8-2.8-2.9
Incentive Sensitization - Responses0.50.51.3-0.4-0.30.00.20.10.5-0.4-0.9-1.1-1.1-1.1
Incentive Sensitization - Breakpoint0.50.51.2-0.3-0.50.10.10.20.6-0.5-0.8-1.1-1.1-1.0
Sum of active levers in priming session hrs 5-60.50.54.2-0.7-2.00.1-0.60.20.2-0.2-0.0-0.3-0.3-0.1
Progressive ratio1.31.54.90.6-2.21.3-1.71.41.3-1.30.9-0.3-0.30.0
Food seeking constrained by brief footshock0.20.30.8-0.00.2-0.20.1-0.4-0.20.30.60.90.90.8
Seeking ratio, punishment vs. effort1.11.44.2-0.32.0-1.21.5-1.4-1.31.3-0.31.01.00.6
Retroperitoneal fat weight2.27.212.73.3-1.93.3-3.43.43.5-3.61.9-0.8-0.8-0.3
Reaction time number correct0.50.81.81.3-0.70.9-0.80.91.3-1.30.1-0.5-0.5-0.3
Reaction time mean minus median1.21.63.91.1-0.60.6-1.00.30.4-0.51.72.02.01.8
Reaction time mean minus median AUC2.12.74.81.7-2.21.6-1.91.51.4-1.62.01.21.21.3
Reaction time num false alarms2.02.74.71.4-2.12.1-2.12.21.9-2.11.3-0.5-0.5-0.1
Reaction time num false alarms AUC2.73.86.51.6-2.52.5-2.42.62.3-2.51.3-0.9-0.9-0.4
Reaction time trials correct on left0.50.81.81.3-0.70.9-0.80.91.3-1.30.1-0.5-0.5-0.3
Reaction time trials on left0.60.92.01.4-0.80.9-0.91.01.3-1.40.2-0.5-0.5-0.2
Reaction time mean1.42.03.61.6-1.01.6-1.61.41.3-1.41.91.21.21.0
Reaction time mean AUC1.41.83.01.4-1.41.6-1.61.51.4-1.41.70.90.90.9
Median of all reaction times1.41.93.31.5-1.21.8-1.71.71.6-1.61.60.50.50.4
Reaction time omissions0.30.41.00.6-1.00.6-0.50.50.3-0.50.80.70.70.6
Reaction time false alarm rate1.11.63.00.8-1.61.7-1.71.71.3-1.51.2-0.4-0.4-0.1
Reaction time premature initiation rate6.48.615.9-2.84.0-3.53.6-3.4-3.33.3-3.2-0.4-0.4-0.8
Reaction time premature initiations3.65.18.6-2.12.9-2.72.9-2.5-2.32.2-2.9-0.8-0.8-1.1
Std. dev. reaction times2.43.35.52.2-1.61.7-2.01.41.4-1.42.31.91.91.8
Reaction time trials completed0.60.92.01.4-0.80.9-0.91.01.3-1.40.2-0.5-0.5-0.2
Reaction time trials AUC0.60.92.01.4-0.81.0-0.91.01.3-1.40.3-0.4-0.4-0.2
Run reversals in cocaine runway, females0.40.31.0-0.10.2-0.1-0.1-0.3-0.50.50.90.80.81.0
Run reversals in cocaine runway, males0.20.10.4-0.00.3-0.0-0.1-0.1-0.40.30.60.50.50.5
Latency to leave start box in cocaine runway0.80.82.4-0.10.2-0.60.2-0.6-0.90.90.51.61.61.3
Latency to leave start box in cocaine runway, F1.51.62.5-0.41.5-1.40.6-1.5-1.61.6-0.11.41.41.2
Latency to leave start box in cocaine runway, M1.51.44.00.7-2.01.5-0.91.61.3-1.31.30.20.20.3
Std. dev. time between licks in bursts0.30.30.7-0.50.8-0.50.4-0.7-0.40.4-0.5-0.6-0.6-0.1
Total sessions with >9 infusions1.51.62.40.4-1.41.2-0.81.51.6-1.6-0.3-1.6-1.6-1.3
Short access day 1 total inactive lever presses3.23.68.6-2.2-1.0-0.71.3-0.10.2-0.2-2.7-2.8-2.8-2.9
Short access day 10 total inactive lever presses0.80.91.8-0.71.1-1.21.3-1.2-1.11.1-0.90.20.2-0.1
Short access day 1 total infusions4.14.410.6-0.5-3.31.5-1.52.12.2-2.2-0.6-2.5-2.5-2.2
Short access day 10 total infusions0.50.51.3-0.6-0.5-0.00.30.20.3-0.3-1.0-1.1-1.1-1.1
Short access total infusions1.51.74.5-0.6-2.10.8-0.71.11.3-1.2-0.6-1.7-1.7-1.5
Short access day 1 locomotion4.44.710.40.9-3.22.1-1.62.62.6-2.6-0.3-2.2-2.2-1.8
Short access day 10 total locomotion0.20.30.80.90.40.6-0.30.60.6-0.60.0-0.4-0.4-0.3
Short access total locomotion1.01.01.70.3-1.00.9-0.61.11.2-1.2-0.3-1.3-1.3-1.1
One hour access (0.3 mA shock)1.51.85.30.5-2.31.5-0.91.61.6-1.60.2-1.1-1.1-0.8
Compulsive drug intake2.12.24.01.8-1.61.7-2.01.51.4-1.41.90.60.61.0
One hour access (shock baseline)1.01.22.9-1.1-0.6-0.20.90.10.3-0.3-1.5-1.6-1.6-1.7
Social response proportion1.71.83.61.6-1.61.5-1.41.61.2-1.31.90.80.80.8
Social responses0.30.31.6-1.3-0.9-0.30.60.1-0.10.2-0.3-0.1-0.1-0.7
Social time1.11.44.40.9-2.11.3-1.01.41.0-0.91.50.80.80.5
Soleus weight0.51.32.61.30.11.5-1.41.51.6-1.51.0-0.6-0.6-0.3
Bone: stiffness0.91.42.8-1.01.5-1.51.4-1.5-1.51.7-0.60.40.40.5
Tibialis anterior weight0.51.86.22.5-0.61.7-1.61.51.3-1.21.40.40.40.8
Time to tail flick, vehicle, before self-admin2.32.46.4-0.10.6-0.70.4-0.9-1.31.31.52.52.52.3
Time to tail flick, vehicle, after self-admin0.10.10.2-0.30.2-0.40.4-0.5-0.40.40.00.30.30.3
Time to tail flick, test, before self-admin0.10.10.1-0.10.10.1-0.30.20.2-0.2-0.1-0.3-0.3-0.3
Time to tail flick, test, after self-admin0.20.21.1-1.1-0.4-0.40.6-0.2-0.30.3-0.3-0.1-0.1-0.3
Delta time to tail flick, vehicle, before/after SA0.60.61.7-0.1-0.20.00.10.10.4-0.4-1.1-1.3-1.3-1.2
Delta time to tail flick, test, before/after SA0.10.10.2-0.3-0.2-0.00.2-0.0-0.10.10.50.30.30.3
Tibia length0.92.56.62.6-1.61.9-2.11.81.4-1.41.50.30.30.8
Ambulatory time before self-admin0.70.82.60.7-0.10.6-0.80.30.2-0.21.61.11.11.3
Ambulatory time after self-admin0.80.95.7-0.4-2.40.6-0.50.80.8-0.80.0-0.7-0.7-0.6
Bone: tissue strength0.10.10.20.5-0.20.4-0.40.40.4-0.20.4-0.0-0.00.3
Total heroin consumption1.11.22.70.7-1.71.4-1.41.31.2-1.21.3-0.0-0.00.2
Bone: trabecular number0.40.61.9-0.5-0.0-0.71.0-0.7-1.41.0-0.9-0.5-0.5-0.3
Bone: trabecular spacing0.20.20.70.20.8-0.2-0.2-0.40.20.20.50.30.30.8
Bone: trabecular thickness0.50.61.9-0.50.4-0.81.1-0.7-1.41.1-0.70.40.4-0.1
Bone: trabecular tissue density0.60.82.01.01.20.2-0.4-0.10.10.21.21.11.11.4
Water consumed over 24 hours0.30.41.00.8-0.30.0-0.20.0-0.40.60.41.01.00.8
Number of responses in last shaping day1.11.22.7-0.8-1.6-0.20.30.20.3-0.3-1.7-1.5-1.5-1.5