Ep300

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Ep300	0.02	0.01	9.9e-03	0	0	-0	0	1.5e-01	1.7e-01	3.8e-01	2.4e-01
2	Liver	gene expression	Ep300	0.03	0.02	3.0e-03	0.03	0.01	0.01	0.01	4.5e-04	8.7e-03	1.0e-02	5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2
Bone: apparent density	0.6	1.1	1.5	-0.8	1.2
Area under the delay curve	0.1	0.1	0.1	-0.2	0.4
BMI with tail	0.5	1.8	3.4	1.8	-0.5
BMI without tail	0.1	0.4	0.9	-0.0	0.9
Body weight	0.7	3.2	4.8	2.2	-1.3
Weight adjusted by age	0.0	0.0	0.1	-0.1	0.2
Bone surface	0.5	0.9	1.2	-0.7	1.1
Bone volume	0.2	0.3	0.4	-0.4	0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.0	0.4
Number of licking bursts	0.6	1.0	1.0	-1.0	1.0
Context. condit. distance diff. score	8.3	10.0	10.9	3.0	-3.3
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	0.1
Locomotion distance, session 1	1.8	2.3	3.4	-1.8	1.1
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	-0.2
Locomotion distance, session 2	3.8	5.3	6.6	-2.0	2.6
Locomotion velocity, session 3	0.6	0.7	1.2	0.4	-1.1
Locomotion distance, session 3	0.6	0.6	1.1	-1.0	-0.4
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	0.8	0.1
Stereotopy head waving duration, day 3	1.7	2.0	3.7	1.9	-0.5
Locomotion velocity, session 7	0.4	0.5	0.8	0.4	-0.9
Locomotion distance, session 7	0.1	0.1	0.2	0.0	-0.4
Stereotopy head waving bouts, day 7	2.0	2.2	2.8	1.3	-1.7
Stereotopy head waving duration, day 7	2.0	2.4	3.3	1.2	-1.8
Locomotion velocity, session 8	1.3	1.5	2.8	1.7	-0.4
Locomotion distance, session 8	1.0	1.4	1.6	1.1	-1.3
Degree of sensitization distance	1.5	1.6	2.8	1.7	-0.6
Degree of sensitization stereotypy	1.8	1.9	2.5	1.1	-1.6
Conditioned locomotion	0.9	1.0	1.2	0.9	-1.1
Cocaine response after cond. corrected	0.1	0.1	0.1	0.4	-0.3
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.1	-0.2
Cocaine response before conditioning	0.3	0.4	0.6	-0.8	0.4
Saline control response	0.2	0.3	0.6	-0.2	-0.8
Bone: connectivity density	0.3	0.4	0.7	-0.4	0.8
Bone: cortical apparent density	0.7	1.0	1.5	-1.2	0.7
Bone: cortical area	0.9	1.3	2.6	1.6	-0.1
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.4
Bone: cortical porosity	0.8	0.9	1.1	1.0	-0.8
Bone: cortical thickness	0.3	0.6	0.6	0.8	0.8
Bone: cortical thickness	0.6	0.7	0.7	0.8	0.8
Bone: cortical tissue density	0.7	0.9	1.4	-1.2	0.7
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.3	0.8
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	0.7	-0.6
Condit. Reinf. active responses	1.5	1.8	1.9	-1.3	1.4
Condit. Reinf. inactive responses	2.3	2.8	3.5	-1.9	1.4
Incentive salience index mean	0.8	0.9	1.4	-0.7	1.2
Condit. Reinf. lever presses	1.2	1.6	1.9	-1.2	1.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.3	0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.5	0.8
Condit. Reinf. active responses	0.3	0.4	0.9	0.9	0.0
Condit. Reinf. inactive responses	0.6	0.8	1.0	1.0	-0.7
Condit. Reinf. lever presses	0.5	0.6	1.0	-0.5	1.0
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.7	0.2
Conditioned reinforcement - actives	0.4	0.6	1.2	1.1	-0.3
Conditioned reinforcement - inactives	0.8	1.1	2.1	0.5	1.4
Conditioned locomotion	1.2	1.5	2.9	1.7	0.3
Patch foraging indifference point 0 sec	1.1	2.0	3.4	-0.8	1.8
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.5	0.4
Delay disc. indifference point, 0s delay	0.7	0.8	1.1	1.1	-0.7
Delay disc. indifference point, 16s delay	0.8	0.9	1.2	-1.1	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.4	-0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	0.2
Delay disc. indifference point, 4s delay	0.3	0.4	0.7	0.2	0.8
Delay disc. indifference point, 8s delay	0.3	0.4	0.5	-0.7	0.5
Indifference point function ln k	0.5	0.9	1.0	1.0	-0.9
Indifference point function log k	0.5	0.9	1.0	1.0	-0.9
Patch foraging total patch changes 0 sec	1.1	2.1	3.2	-1.0	1.8
Patch foraging total patch changes 12 sec	0.2	0.3	0.5	-0.2	0.7
Patch foraging total patch changes 18 sec	0.6	0.9	1.8	-0.3	1.3
Patch foraging total patch changes 24 sec	0.3	0.5	0.5	-0.7	0.6
Patch foraging total patch changes 6 sec	1.7	2.6	4.8	-0.7	2.2
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.3	-0.3
Patch foraging water rate 0 sec	0.4	0.9	1.5	-0.5	1.2
Patch foraging water rate 12 sec	0.2	0.4	0.5	-0.7	0.6
Patch foraging water rate 18 sec	1.6	2.4	2.5	-1.5	1.6
Patch foraging water rate 24 sec	0.1	0.1	0.1	0.1	0.4
Patch foraging water rate 6 sec	0.9	1.3	2.0	-1.4	0.8
Seeking ratio, delayed vs. immediate footshock	2.9	3.5	3.9	-2.0	1.8
Distance traveled before self-admin	0.2	0.2	0.4	-0.3	0.6
Distance traveled after self-admin	1.9	2.3	4.7	-0.1	2.2
Extensor digitorum longus weight	0.1	0.5	0.6	-0.8	0.6
Bone: elastic displacement	0.0	0.0	0.1	0.0	-0.3
Bone: elastic work	1.4	1.9	3.2	1.8	-0.8
Bone: endosteal estimation	0.4	0.8	1.1	0.7	-1.0
Bone: endosteal perimeter	1.2	2.5	2.8	1.7	-1.5
Epididymis fat weight	2.5	8.7	9.2	2.9	-3.0
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.6	-0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.2	0.2
Delay discount exponential model param	0.1	0.1	0.1	0.3	-0.4
Extinction: sum of active levers before priming	0.6	0.7	1.0	1.0	-0.6
Active lever presses in extinction session 6	0.1	0.1	0.1	0.2	-0.3
Bone: final force	0.7	1.1	2.2	1.5	-0.1
Bone: final moment	0.8	1.2	2.4	1.6	0.0
Food consumed during 24 hour testing period	0.9	1.2	2.3	1.5	-0.4
Glucose	0.1	0.2	0.4	-0.1	0.6
Heart weight	4.3	6.6	12.2	3.5	-1.0
Delay discount hyperbolic model param	0.1	0.1	0.1	0.1	-0.3
Intermittent access intake day 1-15 change	0.1	0.2	0.3	-0.5	0.4
Intermittent access intake escalation	0.2	0.3	0.4	-0.7	0.4
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.8	0.2
Intermitt. access day 1 inactive lever presses	0.2	0.7	0.8	0.9	0.8
Intermitt. access day 15 inactive lever presses	0.7	1.4	2.4	0.6	1.6
Intermitt. access escalation Index	0.5	0.7	1.4	-0.3	1.2
Intermittent access day 1 total infusions	0.5	0.7	1.5	1.2	0.0
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.1	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	0.2	-0.3
Intermittent access total infusions	0.2	0.2	0.5	0.7	-0.1
Intermittent access day 1 locomotion	0.4	0.5	0.7	0.5	0.9
Intermittent access day 15 total locomotion	0.0	0.1	0.2	0.4	0.0
Intermittent access total locomotion	0.1	0.1	0.3	0.5	-0.1
Intermittent access standard deviation	0.2	0.4	0.7	0.9	-0.3
Left kidney weight	7.8	36.3	54.6	7.4	-4.2
Right kidney weight	8.7	39.4	60.1	7.8	-4.3
Cocaine induced anxiety	0.6	0.9	0.9	1.0	-0.9
Post-drug Anxiety	0.0	0.1	0.1	0.0	-0.3
Baseline Anxiety	1.0	1.2	1.7	-1.3	0.8
Tail length	0.4	1.4	2.5	-1.6	0.5
Length with tail	0.2	0.8	1.2	0.6	-1.1
Length without tail	1.6	5.1	6.6	2.6	-1.9
Times rat made contact with spout	0.4	0.5	1.0	1.0	0.0
Lifetime Intake	0.6	0.7	1.5	1.2	0.2
Liver weight, left	2.4	3.9	6.1	1.3	-2.5
Liver weight, right	4.0	6.9	10.5	1.8	-3.2
Locomotor activity	1.6	2.5	2.8	1.7	-1.5
Locomotor testing distance	0.0	0.1	0.2	-0.4	0.0
Locomotor testing rearing	1.1	2.2	2.2	1.4	-1.5
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	0.3
Locomotion in novel chamber post-restriction	0.4	0.7	1.4	-1.2	-0.0
Fecal boli incidents, locomotor time 1	0.3	0.4	0.4	-0.6	0.6
Change in fecal boli incidents, locomotor task	0.7	0.7	0.9	0.9	-0.8
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.2
Bouts of movement, locomotor time 1	1.3	1.5	2.7	0.6	-1.6
Total resting periods, locomotor time 1	0.5	0.6	1.0	0.4	-1.0
Rest time, locomotor task time 1	0.4	0.5	0.8	0.9	-0.4
Distance moved, locomotor task time 1	0.3	0.4	0.6	0.5	-0.8
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.1	0.1
Time >=10cm from walls, locomotor time 2	0.3	0.5	0.8	-0.5	0.9
Bouts of movement, locomotor time 2	0.2	0.3	0.5	0.7	-0.1
Total resting periods, locomotor time 2	0.1	0.2	0.4	0.6	0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.1	0.3
Distance moved, locomotor task time 2	0.6	0.7	0.7	0.8	-0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.1	0.4	-0.3
Light reinforcement 1	0.0	0.1	0.1	0.3	0.2
Light reinforcement 2	0.9	1.4	1.4	1.1	-1.2
Bone: marrow area	0.4	0.8	1.1	0.8	-1.0
Bone: maximum diameter	2.1	4.0	7.3	2.7	-0.8
Bone: maximum force	1.1	2.0	3.9	2.0	-0.1
Bone: maximum moment	1.3	2.2	4.4	2.1	-0.1
Mean time between licks in bursts	0.1	0.4	0.4	-0.6	0.6
Mean num. licks in bursts	1.7	2.7	3.3	1.8	-1.4
Cd content in liver	1.0	1.1	1.9	1.4	-0.6
Co content in liver	0.8	0.9	1.9	0.2	1.4
Cu content in liver	6.9	8.2	8.6	-2.9	2.8
Fe content in liver	0.3	0.3	0.5	0.7	0.4
K content in liver	1.6	1.5	1.8	-1.3	1.1
Mg content in liver	1.8	1.8	2.2	-1.2	1.5
Mn content in liver	0.1	0.1	0.2	-0.0	-0.5
Na content in liver	2.0	2.1	2.4	-1.6	1.4
Rb content in liver	0.3	0.3	0.5	0.3	0.7
Se content in liver	0.3	0.4	0.7	-0.8	0.1
Sr content in liver	1.3	1.1	1.4	-1.2	0.9
Zn content in liver	0.1	0.1	0.1	-0.2	0.3
Bone: minimum diameter	0.4	0.7	0.9	1.0	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.1
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.4	-0.7
Total zone transitions, hab. session 1	2.3	3.2	5.4	-2.3	1.0
Total locomotion distance, hab. session 1	1.1	1.5	3.0	-1.7	0.1
Locomotion velocity, hab. session 1	1.4	2.0	3.6	-1.9	0.6
Time in familiar zone, hab. session 2	0.7	0.7	1.4	0.3	-1.2
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.1	0.8
Total zone transitions, hab. session 2	1.9	2.4	3.4	-1.2	1.9
Total locomotion distance, hab. session 2	1.5	2.0	2.8	-1.1	1.7
Locomotion velocity, hab. session 2	2.2	3.0	3.8	-1.5	2.0
Novel to familiar place preference ratio	1.8	1.9	1.9	1.4	-1.4
Novelty place preference	2.7	2.9	3.1	1.7	-1.8
Time in novel zone, NPP test	3.3	3.5	3.7	1.9	-1.8
Total zone transitions, NPP test	2.6	3.7	4.7	-2.2	1.7
Total locomotion distance, NPP test	1.6	2.1	2.3	-1.5	1.4
Locomotion velocity, NPP test	2.1	2.9	3.7	-1.9	1.4
Intraocular pressure	0.7	1.0	1.6	0.7	-1.3
Delta distance traveled before/after self-admin	0.4	0.4	0.6	0.8	0.6
Delta ambulatory time before/after self-admin	0.5	0.6	0.8	0.9	0.7
Parametrial fat weight	0.4	0.9	1.7	0.1	-1.3
Pavlov. Cond. lever latency	0.7	0.9	1.3	1.1	-0.7
Pavlov. Cond. magazine entry latency	0.6	0.8	0.8	-0.9	0.9
Pavlov. Cond. change in total contacts	2.2	2.4	3.7	-1.0	1.9
Pavlov. Cond. index score	0.5	0.6	0.7	-0.7	0.9
Pavlov. Cond. latency score	0.5	0.6	0.6	-0.8	0.8
Pavlov. Cond. lever contacts	1.7	2.1	2.8	-1.7	1.2
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.2	-1.2	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.7	-0.8	0.8
Pavlov. Cond. response bias	0.9	1.2	1.2	-1.1	1.0
Pavlov. Cond. lever latency	1.6	2.1	3.2	1.1	-1.8
Pavlov. Cond. magazine entry latency	4.2	5.0	6.4	-1.9	2.5
Pavlov. Cond. change in total contacts	2.0	3.1	6.1	-0.4	2.5
Pavlov. Cond. index score	2.7	3.7	5.0	-1.5	2.2
Pavlov. Cond. latency score	3.6	4.8	6.3	-1.8	2.5
Pavlov. Cond. lever contacts	1.9	2.6	3.5	-1.3	1.9
Pavlov. Cond. magazine entry number	2.3	2.9	3.8	1.4	-1.9
Pavlov. Cond. intertrial magazine entries	1.5	2.3	3.7	1.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.9	5.1	-1.6	2.3
Pavlov. Cond. response bias	2.1	2.8	4.4	-1.1	2.1
Time in closed arm before self-admin	5.3	6.8	8.3	-2.9	2.3
Time in closed arm after self-admin	0.0	0.0	0.0	-0.2	-0.1
Time in open arm before self-admin	0.4	0.5	0.9	0.1	-1.0
Time in open arm after self-admin	0.3	0.3	0.5	-0.4	-0.7
Bone: periosteal estimation	0.6	1.3	1.9	1.4	-0.8
Bone: periosteal perimeter	2.7	4.7	6.4	2.5	-1.7
Bone: post-yield work	0.3	0.5	0.6	0.7	0.7
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.6	0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.5	-0.0
Progressive ratio test 1 inactive lever presses	0.6	0.9	1.1	1.1	0.8
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.6	0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.2	0.5	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.4	0.5
Incentive Sensitization - Responses	0.0	0.1	0.1	0.0	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	0.2	0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.2
Progressive ratio	0.1	0.1	0.2	-0.5	0.1
Food seeking constrained by brief footshock	1.2	1.5	2.6	1.6	-0.6
Seeking ratio, punishment vs. effort	0.5	0.8	1.5	1.2	-0.2
Retroperitoneal fat weight	3.9	16.6	18.2	4.3	-3.9
Reaction time number correct	0.4	0.7	1.5	-1.2	-0.2
Reaction time mean minus median	0.1	0.2	0.4	0.2	-0.6
Reaction time mean minus median AUC	0.6	1.6	2.2	0.9	-1.5
Reaction time num false alarms	0.0	0.0	0.0	-0.0	-0.2
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.1	-0.3
Reaction time trials correct on left	0.4	0.7	1.5	-1.2	-0.2
Reaction time trials on left	0.4	0.8	1.6	-1.2	-0.2
Reaction time mean	0.0	0.1	0.1	-0.3	0.2
Reaction time mean AUC	0.0	0.0	0.0	-0.2	0.2
Median of all reaction times	0.2	0.2	0.3	-0.5	0.5
Reaction time omissions	0.1	0.1	0.1	-0.3	-0.3
Reaction time false alarm rate	0.1	0.2	0.3	0.5	-0.2
Reaction time premature initiation rate	1.4	1.9	3.5	-0.6	1.9
Reaction time premature initiations	0.8	1.4	2.0	-0.9	1.4
Std. dev. reaction times	0.3	0.5	0.5	0.7	-0.7
Reaction time trials completed	0.4	0.8	1.6	-1.2	-0.2
Reaction time trials AUC	0.3	0.6	1.2	-1.1	-0.2
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.7	0.3
Run reversals in cocaine runway, males	2.1	2.1	3.3	0.9	-1.8
Latency to leave start box in cocaine runway	0.4	0.5	0.9	0.2	-1.0
Latency to leave start box in cocaine runway, F	0.1	0.2	0.3	-0.6	-0.1
Latency to leave start box in cocaine runway, M	1.5	1.4	1.7	1.0	-1.3
Std. dev. time between licks in bursts	2.3	3.1	4.4	-1.3	2.1
Total sessions with >9 infusions	2.7	3.2	6.5	2.5	0.2
Short access day 1 total inactive lever presses	1.8	2.4	2.8	1.4	1.7
Short access day 10 total inactive lever presses	0.5	1.1	1.6	1.2	-0.9
Short access day 1 total infusions	1.3	1.7	2.7	1.6	0.9
Short access day 10 total infusions	0.6	0.8	1.6	1.3	-0.0
Short access total infusions	1.8	2.3	4.2	2.0	0.7
Short access day 1 locomotion	0.4	0.5	0.6	0.7	0.6
Short access day 10 total locomotion	0.2	0.4	0.9	-0.2	0.9
Short access total locomotion	0.6	0.7	1.1	1.0	0.6
One hour access (0.3 mA shock)	0.0	0.0	0.0	-0.0	0.1
Compulsive drug intake	0.4	0.5	0.9	-0.2	0.9
One hour access (shock baseline)	0.0	0.1	0.1	0.0	-0.4
Social response proportion	0.2	0.3	0.5	0.2	0.7
Social responses	0.1	0.1	0.2	-0.5	0.3
Social time	1.5	2.1	2.1	-1.4	1.5
Soleus weight	0.3	0.9	1.7	-0.2	1.3
Bone: stiffness	0.7	1.1	2.1	1.4	0.2
Tibialis anterior weight	0.7	2.5	2.6	-1.5	1.6
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.5	0.7	1.4	-1.2	0.1
Time to tail flick, test, before self-admin	1.5	1.6	2.4	0.9	-1.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	0.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.2	0.0
Delta time to tail flick, test, before/after SA	2.8	2.8	3.2	-1.6	1.8
Tibia length	0.5	1.4	2.4	1.6	-0.6
Ambulatory time before self-admin	0.1	0.2	0.3	-0.2	0.5
Ambulatory time after self-admin	2.6	3.0	5.2	-0.9	2.3
Bone: tissue strength	0.1	0.1	0.2	0.4	-0.2
Total heroin consumption	0.1	0.2	0.3	0.5	0.2
Bone: trabecular number	0.0	0.1	0.1	-0.1	-0.3
Bone: trabecular spacing	0.9	1.2	2.3	1.5	-0.3
Bone: trabecular thickness	0.3	0.3	0.6	-0.8	0.2
Bone: trabecular tissue density	2.9	4.3	4.8	-2.2	2.0
Water consumed over 24 hours	0.1	0.2	0.4	0.6	0.1
Number of responses in last shaping day	2.0	2.2	4.0	-0.7	2.0