Hub : Genes

Entpd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Entpd1 0.08 0.06 5.4e-03 0.04 0.05 0.05 0.04 3.4e-03 1.5e-03 1.5e-03 3.0e-03
2 NAcc gene expression Entpd1 0.36 0.11 0.0e+00 0.43 0.47 0.47 0.48 8.3e-54 3.9e-61 8.7e-61 5.2e-62
3 OFC gene expression Entpd1 0.28 0.13 2.2e-06 0.27 0.25 0.21 0.27 3.9e-07 1.0e-06 8.0e-06 4.4e-07
4 Adipose gene expression Entpd1 0.1 0.05 1.3e-11 0.1 0.08 0.08 0.1 3.4e-11 3.8e-09 1.2e-09 8.4e-11
5 NAcc intron excision ratio chr1_239473951_239521887 0.03 0.02 2.3e-03 0.02 0.01 0.01 0.01 5.4e-03 1.9e-02 3.7e-02 4.7e-02
6 PL mRNA stability Entpd1 0.04 0.02 1.5e-04 0.03 0.04 0.03 0.03 1.3e-04 7.0e-05 2.4e-04 1.2e-04
7 Liver gene expression Entpd1 0.15 0.1 1.5e-04 0.02 0.03 0.01 0.02 1.5e-03 7.5e-04 9.6e-03 2.1e-03
8 NAcc isoform ratio NM_022587.2 0.03 0.02 1.3e-03 0.02 0.02 0.02 0.02 6.7e-04 1.2e-03 4.7e-03 1.6e-03
9 Brain gene expression Entpd1 0.11 0.06 3.9e-10 0.1 0.11 0.12 0.11 1.2e-09 4.0e-10 5.5e-11 1.8e-10
10 NAcc isoform ratio XM_017589665.2 0.02 0.01 6.8e-03 0.01 0.01 0.01 0.01 6.3e-03 5.8e-03 1.1e-02 8.2e-03
11 NAcc mRNA stability Entpd1 0.03 0.02 1.7e-03 0.02 0.02 0.02 0.02 1.5e-03 7.1e-04 1.2e-03 2.3e-03
12 pVTA gene expression Entpd1 0.07 0.05 5.0e-03 0.01 0.04 0 0.01 8.1e-02 9.0e-03 1.8e-01 7.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.71.21.71.11.0-1.01.0-1.0-1.1-1.11.1-1.31.0-1.2-1.0
Area under the delay curve0.80.92.3-1.5-1.21.4-1.30.90.90.5-0.40.1-0.70.20.4
BMI with tail0.82.67.72.81.9-1.61.8-1.8-1.6-1.71.2-1.11.1-1.1-0.8
BMI without tail1.42.95.82.41.9-1.61.9-1.7-1.8-1.81.1-1.51.4-1.4-1.2
Body weight0.41.65.42.31.7-1.61.6-1.5-1.2-0.90.6-0.60.8-0.4-0.4
Weight adjusted by age0.30.31.81.30.5-0.70.4-0.5-0.5-0.20.7-0.10.0-0.20.1
Bone surface2.03.56.51.51.7-1.61.7-1.7-1.9-2.02.6-1.91.8-2.0-1.9
Bone volume1.93.24.91.71.7-1.71.7-1.8-1.8-1.82.2-1.91.7-1.8-1.7
Breakpoint value in progressive ratio session0.60.71.8-1.0-0.91.2-0.70.30.80.2-0.41.3-0.70.70.6
Number of licking bursts1.92.23.3-1.4-1.81.7-1.71.81.61.4-1.21.0-1.61.21.4
Context. condit. distance diff. score0.30.31.41.20.6-0.40.6-0.8-0.3-0.30.9-0.2-0.00.20.3
Locomotion velocity, session 14.64.97.6-2.6-2.82.7-2.62.42.31.9-2.21.2-2.11.61.8
Locomotion distance, session 11.31.62.9-1.7-1.61.5-1.51.31.41.3-0.70.6-1.21.01.0
Locomotion velocity, session 20.60.73.5-1.9-1.11.1-1.01.00.6-0.1-0.20.3-0.1-0.4-0.3
Locomotion distance, session 20.60.81.3-1.1-1.10.9-1.11.10.91.0-0.40.6-0.80.50.7
Locomotion velocity, session 30.10.10.4-0.5-0.10.1-0.10.10.30.50.10.6-0.10.40.2
Locomotion distance, session 30.10.10.2-0.10.4-0.50.5-0.4-0.10.30.20.40.20.3-0.1
Stereotopy head waving bouts, day 30.40.40.9-0.2-0.70.6-0.60.50.70.6-0.50.9-0.80.80.8
Stereotopy head waving duration, day 30.50.61.0-0.2-0.80.8-0.80.60.70.6-0.71.0-0.90.81.0
Locomotion velocity, session 70.60.71.00.50.9-0.90.8-0.9-0.8-0.60.5-1.00.9-0.8-0.9
Locomotion distance, session 70.81.02.50.61.0-1.11.0-1.0-1.0-0.60.1-1.61.1-1.0-1.1
Stereotopy head waving bouts, day 72.62.96.9-1.3-1.82.1-1.71.41.81.10.12.6-1.81.81.8
Stereotopy head waving duration, day 70.91.04.4-0.5-0.91.1-0.80.70.90.40.72.1-1.01.01.0
Locomotion velocity, session 80.10.10.6-0.2-0.30.3-0.1-0.10.2-0.00.8-0.0-0.20.20.2
Locomotion distance, session 80.10.10.40.3-0.30.4-0.20.00.30.30.4-0.1-0.60.50.7
Degree of sensitization distance0.20.21.00.1-0.40.3-0.50.40.10.1-1.0-1.0-0.3-0.20.2
Degree of sensitization stereotypy2.32.57.0-1.1-1.61.8-1.51.21.61.10.52.7-1.61.71.7
Conditioned locomotion1.51.75.32.31.5-1.41.6-1.5-1.3-1.21.3-0.80.8-0.6-0.5
Cocaine response after cond. corrected0.10.10.2-0.1-0.40.4-0.30.10.40.3-0.40.3-0.50.30.5
Cocaine response after cond. not corrected0.30.41.0-0.8-0.60.6-0.50.50.60.6-1.00.2-0.50.50.4
Cocaine response before conditioning1.01.23.5-1.9-1.00.9-1.01.31.01.3-1.50.0-0.60.80.4
Saline control response2.22.84.1-1.4-1.71.8-1.61.51.81.7-0.41.8-1.92.01.9
Bone: connectivity density2.74.26.41.51.7-1.71.7-1.7-2.1-2.32.2-2.32.1-2.5-2.2
Bone: cortical apparent density2.43.13.9-1.2-1.81.7-1.81.71.81.8-1.91.5-2.01.82.0
Bone: cortical area0.91.32.61.61.5-1.41.4-1.6-0.9-0.51.5-0.40.7-0.0-0.3
Bone: cortical porosity0.30.30.5-0.3-0.60.7-0.70.70.50.4-0.50.5-0.60.20.5
Bone: cortical porosity0.10.10.2-0.1-0.20.3-0.40.40.20.3-0.30.5-0.30.10.3
Bone: cortical thickness1.21.95.3-0.4-0.70.9-0.80.61.41.8-0.61.9-1.72.31.9
Bone: cortical thickness2.63.04.1-1.6-1.71.9-1.61.51.91.7-1.61.8-1.82.01.8
Bone: cortical tissue density2.33.03.7-1.2-1.81.7-1.81.71.81.7-1.91.5-1.91.71.9
Condit. Reinf. active minus inactive responses0.50.61.6-1.2-0.70.6-0.90.60.81.0-0.80.4-0.50.60.4
Condit. Reinf. active-inactive response ratio0.20.20.6-0.8-0.30.2-0.50.10.30.6-0.7-0.2-0.10.20.1
Condit. Reinf. active responses0.40.51.1-1.0-0.50.4-0.80.60.71.1-1.00.4-0.50.60.5
Condit. Reinf. inactive responses0.50.50.9-0.4-0.60.5-0.70.90.70.9-0.80.7-0.80.70.8
Incentive salience index mean0.40.51.9-1.4-0.60.6-0.80.50.70.9-0.90.2-0.40.60.3
Condit. Reinf. lever presses0.30.41.4-1.2-0.60.7-0.60.50.60.5-1.00.1-0.40.50.2
Condit. Reinf. active minus inactive responses1.92.44.52.11.8-1.71.7-1.7-1.6-1.21.4-1.71.2-1.1-1.0
Condit. Reinf. active-inactive response ratio1.01.02.81.71.1-1.11.1-1.1-1.0-0.80.7-1.30.6-0.6-0.5
Condit. Reinf. active responses1.31.93.01.71.7-1.51.6-1.6-1.3-1.11.6-0.81.2-0.8-0.9
Condit. Reinf. inactive responses0.20.20.90.10.5-0.20.5-0.5-0.2-0.20.90.80.30.2-0.2
Condit. Reinf. lever presses0.10.10.9-1.0-0.20.3-0.10.30.20.1-0.60.20.10.0-0.3
Condit. Reinf. lever reinforcers received0.71.01.51.11.2-1.11.2-1.2-1.0-0.81.2-0.60.9-0.6-0.7
Conditioned reinforcement - actives0.50.51.0-0.9-0.70.4-0.90.70.61.0-0.90.6-0.40.50.4
Conditioned reinforcement - inactives0.20.20.9-1.0-0.50.9-0.70.20.4-0.10.0-0.3-0.1-0.0-0.1
Conditioned locomotion1.01.23.3-1.8-1.20.8-1.41.11.01.4-1.30.6-0.70.60.5
Patch foraging indifference point 0 sec0.10.20.9-1.0-0.40.5-0.40.20.30.00.20.3-0.00.2-0.1
Patch foraging indifference point AUC3.33.88.0-2.8-2.42.4-2.41.92.11.5-0.81.5-1.61.51.4
Delay disc. indifference point, 0s delay0.80.91.61.00.7-0.60.7-0.8-0.9-1.21.3-1.00.8-1.1-0.8
Delay disc. indifference point, 16s delay0.70.72.0-1.4-1.11.2-1.10.90.80.4-0.10.3-0.60.30.4
Delay disc. indifference point, 2s delay0.50.52.0-0.8-0.30.2-0.30.1-0.3-0.7-0.4-1.40.6-1.2-0.9
Delay disc. indifference point, 24s delay3.83.75.7-2.4-2.22.1-2.21.92.01.9-1.51.6-1.81.61.6
Delay disc. indifference point, 4s delay0.50.51.1-0.9-1.01.0-1.00.60.80.5-0.20.0-0.70.40.5
Delay disc. indifference point, 8s delay2.62.76.7-2.6-2.12.2-2.21.71.71.1-1.10.6-1.20.80.9
Indifference point function ln k2.73.78.83.02.3-2.52.5-2.1-2.0-1.40.7-1.41.5-1.3-1.2
Indifference point function log k2.73.78.83.02.3-2.52.5-2.1-2.0-1.40.7-1.41.5-1.3-1.2
Patch foraging total patch changes 0 sec0.10.10.7-0.9-0.20.3-0.30.10.2-0.10.30.20.10.0-0.2
Patch foraging total patch changes 12 sec2.33.07.0-2.6-2.22.3-2.11.81.91.3-0.80.8-1.41.31.1
Patch foraging total patch changes 18 sec0.60.82.5-1.6-1.11.3-1.30.80.80.20.70.2-0.50.20.2
Patch foraging total patch changes 24 sec0.40.52.6-1.6-0.70.5-0.90.50.40.30.90.20.1-0.1-0.3
Patch foraging total patch changes 6 sec2.94.210.4-3.2-2.52.5-2.62.02.21.4-0.81.6-1.61.61.3
Patch foraging time to switch 0 sec0.40.61.5-0.8-1.01.2-0.91.00.80.4-0.50.4-0.80.50.7
Patch foraging water rate 0 sec0.91.52.81.21.2-1.11.2-1.7-1.2-1.41.4-1.01.1-0.9-1.0
Patch foraging water rate 12 sec0.10.20.50.70.7-0.60.5-0.7-0.5-0.40.1-0.00.4-0.1-0.3
Patch foraging water rate 18 sec0.10.10.40.40.4-0.50.2-0.6-0.3-0.2-0.1-0.20.3-0.1-0.2
Patch foraging water rate 24 sec0.30.41.31.10.7-0.70.8-1.1-0.6-0.50.0-0.20.3-0.2-0.2
Patch foraging water rate 6 sec0.20.20.30.30.5-0.50.5-0.6-0.5-0.50.5-0.30.5-0.6-0.5
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.5-0.0-0.20.00.30.20.4-0.30.40.00.2-0.0
Distance traveled before self-admin0.10.10.5-0.7-0.5-0.0-0.40.40.1-0.1-0.20.40.1-0.3-0.3
Distance traveled after self-admin0.91.02.8-0.20.4-1.00.3-0.3-1.0-1.00.5-1.21.3-1.7-1.6
Extensor digitorum longus weight0.10.52.51.60.7-0.90.5-0.4-0.20.5-0.7-0.1-0.40.60.7
Bone: elastic displacement0.30.31.21.10.3-0.40.3-0.4-0.5-0.71.00.30.2-0.6-0.1
Bone: elastic work0.50.62.21.00.5-0.50.5-0.7-0.8-1.11.5-0.10.6-0.8-0.6
Bone: endosteal estimation3.47.48.92.32.7-2.72.7-2.7-2.9-2.92.4-2.62.9-3.0-2.9
Bone: endosteal perimeter3.67.58.82.32.7-2.82.7-2.6-2.9-2.82.6-3.02.9-2.9-2.8
Epididymis fat weight1.63.76.62.62.1-2.22.3-1.9-2.0-1.91.8-1.21.7-1.5-1.5
Delta time in closed arm before/after self-admin0.10.10.3-0.1-0.10.1-0.0-0.10.20.10.60.6-0.20.50.3
Delta time in open arm before/after self-admin1.81.83.50.81.0-0.90.9-1.4-1.3-1.80.7-1.91.4-1.7-1.5
Diff in mean of infusions in LGA sessions1.21.32.60.50.8-0.60.9-1.4-1.1-1.60.8-1.01.3-1.5-1.4
Delay discount exponential model param0.91.02.71.71.3-1.41.4-1.0-1.0-0.50.6-0.10.7-0.3-0.4
Extinction: sum of active levers before priming0.70.71.90.70.7-0.40.9-1.1-0.8-1.41.1-0.20.8-0.7-0.8
Active lever presses in extinction session 60.60.62.80.90.40.10.5-0.8-0.7-1.70.6-0.60.5-0.9-0.6
Bone: final force0.00.10.40.10.1-0.20.2-0.30.10.20.40.6-0.10.40.2
Bone: final moment0.10.10.20.30.4-0.40.4-0.5-0.2-0.10.40.30.20.1-0.1
Food consumed during 24 hour testing period0.70.82.2-1.5-0.90.9-0.90.90.91.0-1.00.4-0.60.70.5
Glucose0.20.31.1-0.10.5-0.40.3-0.3-0.5-0.61.0-0.20.7-0.6-0.8
Heart weight0.10.10.4-0.20.2-0.00.2-0.4-0.2-0.70.60.50.4-0.1-0.4
Delay discount hyperbolic model param0.60.62.11.41.1-1.11.2-0.7-0.7-0.30.50.20.40.0-0.2
Intermittent access intake day 1-15 change2.42.44.31.11.5-1.61.4-1.3-1.6-1.21.6-2.11.6-1.7-1.6
Intermittent access intake escalation2.62.54.71.21.6-1.71.4-1.3-1.6-1.11.6-2.21.6-1.8-1.7
Intermittent access intake escalation 21.71.64.01.41.4-1.51.0-1.0-1.3-0.71.3-2.01.1-1.3-1.0
Intermitt. access day 1 inactive lever presses0.50.51.6-0.00.4-0.40.2-0.1-0.7-1.00.7-0.30.9-1.3-1.1
Intermitt. access day 15 inactive lever presses0.30.30.8-0.50.1-0.10.1-0.1-0.4-0.50.6-0.40.7-0.9-0.9
Intermitt. access escalation Index2.21.93.11.51.6-1.31.8-1.4-1.4-1.50.9-1.11.3-1.3-1.3
Intermittent access day 1 total infusions0.10.10.30.00.1-0.10.2-0.4-0.3-0.5-0.5-0.20.4-0.4-0.4
Intermittent access day 15 total infusions2.12.33.01.11.7-1.71.6-1.6-1.6-1.21.1-1.71.7-1.5-1.7
Intermittent access terminal intake (last 3 days)0.91.01.50.61.0-1.20.9-1.0-1.1-0.80.5-1.21.2-1.2-1.2
Intermittent access total infusions0.60.61.00.60.8-1.00.8-0.9-0.9-0.60.2-0.70.9-0.8-0.9
Intermittent access day 1 locomotion0.30.40.8-0.00.5-0.60.3-0.6-0.6-0.70.2-0.30.8-0.8-0.9
Intermittent access day 15 total locomotion1.01.11.6-1.3-1.10.8-1.31.11.01.2-1.10.8-0.80.80.8
Intermittent access total locomotion0.50.61.1-1.0-1.00.6-1.10.80.70.7-0.70.6-0.50.50.5
Intermittent access standard deviation1.41.42.50.71.2-1.21.0-1.2-1.2-0.91.1-1.61.3-1.3-1.4
Left kidney weight0.10.42.1-1.0-0.40.3-0.10.10.50.4-1.40.4-0.20.80.2
Right kidney weight0.30.91.9-1.4-0.80.9-0.60.20.90.7-1.41.3-0.61.30.6
Cocaine induced anxiety0.10.10.30.0-0.0-0.20.3-0.1-0.3-0.50.1-0.10.3-0.4-0.4
Post-drug Anxiety0.10.10.2-0.0-0.30.3-0.30.40.2-0.0-0.30.1-0.30.20.3
Baseline Anxiety0.10.10.4-0.0-0.00.3-0.30.20.20.2-0.7-0.5-0.30.20.3
Tail length0.00.10.40.30.5-0.60.6-0.4-0.20.1-0.2-0.10.20.3-0.1
Length with tail0.10.51.5-0.6-0.3-0.1-0.30.20.61.2-1.10.8-0.51.20.7
Length without tail0.40.92.2-0.7-0.60.4-0.70.51.01.4-1.11.1-0.91.51.1
Times rat made contact with spout0.20.30.9-1.0-0.60.5-0.50.80.40.5-0.7-0.3-0.1-0.1-0.0
Lifetime Intake0.20.20.40.10.3-0.40.3-0.6-0.5-0.6-0.0-0.40.6-0.6-0.7
Liver weight, left0.20.30.80.10.5-0.90.6-0.4-0.5-0.10.5-0.30.7-0.5-0.7
Liver weight, right0.61.01.60.81.2-1.21.2-1.3-1.0-0.80.8-0.61.1-0.7-1.0
Locomotor activity0.00.10.3-0.10.10.20.0-0.1-0.1-0.50.50.20.2-0.2-0.2
Locomotor testing distance0.20.30.9-0.40.10.20.0-0.3-0.3-0.90.9-0.00.5-0.6-0.7
Locomotor testing rearing0.40.71.60.50.6-0.60.4-0.7-0.8-1.01.3-0.90.8-1.0-0.9
Locomotion in novel chamber1.72.24.12.01.6-1.31.7-1.4-1.6-1.81.3-0.71.3-1.3-1.1
Locomotion in novel chamber post-restriction0.10.10.3-0.6-0.20.4-0.20.20.30.1-0.4-0.2-0.10.20.1
Fecal boli incidents, locomotor time 10.10.10.3-0.1-0.30.6-0.30.20.2-0.00.0-0.0-0.30.10.2
Change in fecal boli incidents, locomotor task0.10.10.4-0.1-0.1-0.00.00.60.20.4-0.30.6-0.20.40.3
Time >=10cm from walls, locomotor time 10.80.81.9-1.3-0.40.5-0.50.80.91.4-1.01.0-0.61.20.6
Bouts of movement, locomotor time 11.92.13.7-1.5-1.71.5-1.61.51.51.2-1.90.7-1.41.11.2
Total resting periods, locomotor time 13.23.55.0-2.0-2.12.1-2.11.91.91.6-2.21.2-1.81.61.6
Rest time, locomotor task time 10.80.81.9-1.0-1.31.1-1.20.80.90.3-1.40.1-0.80.40.7
Distance moved, locomotor task time 10.70.81.70.71.3-1.21.1-1.1-0.8-0.20.9-0.40.9-0.3-0.7
Vertical activity count, locomotor time 10.30.40.8-0.10.9-0.90.7-0.3-0.50.10.8-0.30.8-0.4-0.7
Time >=10cm from walls, locomotor time 20.40.51.1-0.9-0.60.5-0.40.70.70.8-0.31.1-0.50.80.5
Bouts of movement, locomotor time 23.53.86.0-2.4-2.32.1-2.22.31.91.8-2.50.8-1.71.31.4
Total resting periods, locomotor time 24.14.36.9-2.5-2.42.3-2.32.42.11.9-2.61.0-1.91.51.6
Rest time, locomotor task time 21.92.23.4-1.5-1.81.8-1.81.41.61.0-1.31.3-1.51.31.4
Distance moved, locomotor task time 20.81.02.00.81.2-1.41.3-1.4-1.0-0.50.8-0.51.0-0.6-0.9
Vertical activity count, locomotor time 20.40.51.2-0.50.5-0.50.4-0.6-0.5-0.50.9-0.60.9-0.9-1.1
Light reinforcement 10.10.10.3-0.4-0.40.4-0.40.40.20.1-0.6-0.2-0.1-0.10.0
Light reinforcement 22.02.63.7-1.4-1.91.9-1.61.81.71.4-1.81.0-1.71.41.6
Bone: marrow area3.57.58.92.32.7-2.72.8-2.7-2.9-2.92.4-2.52.9-3.0-2.9
Bone: maximum diameter3.87.08.93.02.9-2.82.8-2.9-2.7-2.43.0-2.22.4-2.2-2.2
Bone: maximum force0.10.20.60.80.4-0.50.4-0.6-0.2-0.00.70.0-0.10.30.3
Bone: maximum moment0.20.30.80.90.6-0.70.6-0.8-0.4-0.20.6-0.30.20.0-0.0
Mean time between licks in bursts0.10.10.30.10.4-0.50.4-0.3-0.4-0.30.10.10.5-0.4-0.5
Mean num. licks in bursts1.92.33.11.11.7-1.61.7-1.6-1.6-1.41.0-1.21.7-1.5-1.7
Cd content in liver0.30.41.1-1.0-0.60.6-0.70.80.60.7-0.4-0.1-0.40.40.3
Co content in liver0.60.71.8-0.40.6-0.60.5-0.6-0.8-0.90.5-0.91.2-1.1-1.3
Cu content in liver5.16.113.7-3.7-3.13.1-3.12.92.41.8-2.01.7-1.91.21.4
Fe content in liver1.11.33.5-1.2-1.31.3-1.31.31.10.90.41.9-1.00.70.9
K content in liver0.70.72.7-0.8-0.80.9-0.70.90.70.6-1.60.6-0.70.50.6
Mg content in liver1.11.11.6-0.6-1.11.2-0.91.11.10.9-1.11.3-1.21.01.2
Mn content in liver6.77.69.4-2.3-3.13.1-2.93.02.92.6-2.22.3-3.02.62.9
Na content in liver2.12.24.0-0.6-1.41.6-1.31.21.51.3-1.42.0-1.71.61.8
Rb content in liver0.30.40.8-0.1-0.50.6-0.50.50.60.70.10.9-0.80.80.9
Se content in liver17.621.528.3-5.1-5.15.0-5.15.34.84.6-3.54.4-4.43.94.0
Sr content in liver0.10.10.6-0.8-0.30.3-0.30.40.1-0.20.40.20.2-0.3-0.4
Zn content in liver0.91.01.4-0.8-1.01.0-1.01.01.11.1-0.71.2-1.11.01.1
Bone: minimum diameter6.912.918.14.24.0-3.94.1-4.1-3.6-3.34.3-2.33.2-2.7-2.8
Time in familiar zone, hab. session 10.30.30.60.60.4-0.30.3-0.5-0.4-0.60.8-0.70.3-0.5-0.3
Time in novel zone, hab. session 10.50.50.9-0.9-0.70.6-0.80.70.70.8-0.80.5-0.60.50.5
Total zone transitions, hab. session 10.20.20.6-0.8-0.70.6-0.70.40.50.40.2-0.6-0.30.10.2
Total locomotion distance, hab. session 11.72.54.6-2.2-1.91.8-1.91.61.71.6-1.10.6-1.41.21.2
Locomotion velocity, hab. session 12.94.26.8-2.6-2.32.2-2.32.12.22.1-1.71.0-1.91.81.7
Time in familiar zone, hab. session 20.60.61.31.10.7-0.50.7-1.1-0.7-0.90.6-1.00.5-0.4-0.3
Time in novel zone, hab. session 20.80.82.0-1.4-0.90.7-0.91.20.81.0-0.90.9-0.50.40.4
Total zone transitions, hab. session 20.20.20.4-0.6-0.50.4-0.50.30.50.6-0.3-0.1-0.50.40.4
Total locomotion distance, hab. session 20.40.60.9-0.9-0.90.8-0.80.60.80.8-0.60.2-0.70.70.7
Locomotion velocity, hab. session 20.60.81.1-1.0-1.01.0-1.00.81.01.0-0.70.3-0.90.90.9
Novel to familiar place preference ratio0.20.21.0-0.2-0.40.4-0.30.60.10.0-1.00.1-0.2-0.30.1
Novelty place preference0.20.21.0-0.2-0.40.3-0.30.60.10.0-1.00.1-0.1-0.4-0.0
Time in novel zone, NPP test0.20.21.2-0.2-0.30.3-0.40.70.10.2-1.10.1-0.2-0.30.1
Total zone transitions, NPP test0.40.61.6-1.3-0.70.6-0.80.60.81.1-0.9-0.1-0.60.70.5
Total locomotion distance, NPP test2.73.66.6-2.6-2.12.0-2.01.82.02.1-2.11.1-1.61.71.4
Locomotion velocity, NPP test1.92.75.8-2.4-1.91.8-1.71.51.71.6-1.70.9-1.31.41.1
Intraocular pressure0.10.20.70.60.0-0.00.1-0.3-0.3-0.80.70.20.2-0.5-0.2
Delta distance traveled before/after self-admin2.72.95.21.61.7-1.71.6-1.6-1.8-1.71.3-2.31.7-1.8-1.6
Delta ambulatory time before/after self-admin3.63.96.61.92.0-2.01.9-1.8-2.1-1.91.4-2.62.0-2.1-2.0
Parametrial fat weight0.10.20.5-0.20.7-0.50.7-0.5-0.4-0.40.2-0.20.7-0.2-0.7
Pavlov. Cond. lever latency0.10.10.91.00.4-0.50.3-0.1-0.3-0.00.5-0.1-0.0-0.10.1
Pavlov. Cond. magazine entry latency0.70.94.9-2.2-0.80.9-0.70.80.70.6-1.40.2-0.00.3-0.2
Pavlov. Cond. change in total contacts0.10.10.9-0.9-0.10.2-0.00.00.1-0.0-0.30.10.3-0.0-0.4
Pavlov. Cond. index score0.70.93.9-2.0-0.91.0-0.90.90.90.7-1.10.6-0.30.50.1
Pavlov. Cond. latency score0.40.52.6-1.6-0.60.8-0.50.60.60.3-0.80.6-0.10.4-0.1
Pavlov. Cond. lever contacts0.40.51.9-1.4-0.70.8-0.70.50.70.5-0.70.8-0.40.60.3
Pavlov. Cond. magazine entry number0.30.42.41.50.1-0.10.2-0.30.00.10.70.3-0.70.50.9
Pavlov. Cond. intertrial magazine entries0.50.61.7-0.2-0.50.5-0.70.50.71.0-0.71.3-0.90.91.0
Pavlov. Cond. lever-magazine prob. diff.0.70.93.9-2.0-0.80.9-0.90.90.90.8-1.20.5-0.40.50.1
Pavlov. Cond. response bias0.50.63.6-1.9-0.50.5-0.60.60.50.6-1.20.10.10.1-0.4
Pavlov. Cond. lever latency0.60.84.12.00.9-1.10.8-0.7-0.8-0.41.2-0.30.2-0.30.1
Pavlov. Cond. magazine entry latency0.40.41.5-1.2-0.50.5-0.40.60.60.6-1.1-0.1-0.30.40.1
Pavlov. Cond. change in total contacts0.20.21.3-1.1-0.20.30.0-0.00.0-0.3-0.8-0.40.4-0.4-0.7
Pavlov. Cond. index score0.81.04.2-2.0-1.01.0-0.81.00.90.7-1.60.3-0.40.50.1
Pavlov. Cond. latency score0.81.03.8-2.0-1.01.1-0.81.00.90.8-1.60.4-0.40.60.2
Pavlov. Cond. lever contacts0.40.52.8-1.7-0.70.8-0.50.50.50.3-0.90.3-0.00.2-0.2
Pavlov. Cond. magazine entry number2.22.76.32.51.6-1.61.4-1.7-1.7-1.72.4-0.71.2-1.4-1.0
Pavlov. Cond. intertrial magazine entries0.60.81.91.40.9-0.90.7-0.8-0.9-0.80.7-1.10.6-0.8-0.5
Pavlov. Cond. lever-magazine prob. diff.0.81.04.3-2.1-1.01.1-0.81.00.90.7-1.60.3-0.40.50.1
Pavlov. Cond. response bias0.60.94.4-2.1-0.91.0-0.80.90.80.6-1.30.2-0.20.4-0.0
Time in closed arm before self-admin0.10.10.3-0.4-0.30.0-0.20.4-0.1-0.3-0.40.10.2-0.6-0.4
Time in closed arm after self-admin1.31.32.6-0.8-1.30.4-1.21.31.11.5-0.41.6-1.21.11.2
Time in open arm before self-admin0.00.00.10.30.2-0.20.30.0-0.2-0.20.2-0.20.2-0.3-0.2
Time in open arm after self-admin1.92.04.50.91.2-0.61.2-1.4-1.4-2.11.0-1.91.5-1.6-1.6
Bone: periosteal estimation2.04.15.32.22.2-2.22.2-2.3-2.1-1.92.1-1.61.9-1.6-1.8
Bone: periosteal perimeter2.84.77.92.52.3-2.32.3-2.4-2.2-1.92.8-1.71.9-1.7-1.7
Bone: post-yield work0.20.30.80.90.6-0.60.7-0.7-0.4-0.20.5-0.60.30.0-0.1
Progressive ratio test 1 active lever presses0.00.00.10.20.1-0.20.1-0.2-0.2-0.20.1-0.10.2-0.3-0.2
Progressive ratio test 1 breakpoint0.10.10.30.20.1-0.30.2-0.2-0.3-0.30.1-0.10.3-0.5-0.3
Progressive ratio test 1 inactive lever presses3.13.46.91.21.6-1.21.4-1.7-1.9-2.61.7-1.72.0-2.3-2.2
Progressive ratio test 2 active lever presses0.10.10.4-0.2-0.0-0.2-0.1-0.0-0.10.10.0-0.70.2-0.4-0.2
Progressive ratio test 2 breakpoint0.10.10.4-0.2-0.1-0.2-0.10.0-0.10.1-0.1-0.70.2-0.4-0.3
Progressive ratio test 2 inactive lever presses0.10.21.0-0.3-0.1-0.1-0.30.1-0.2-0.1-0.4-1.00.3-0.6-0.4
Incentive Sensitization - Responses0.40.41.5-0.00.5-0.60.4-0.4-0.5-0.30.4-1.20.7-0.9-0.8
Incentive Sensitization - Breakpoint0.30.31.5-0.10.4-0.40.2-0.3-0.4-0.20.2-1.20.6-0.7-0.7
Sum of active levers in priming session hrs 5-60.10.10.70.10.00.20.0-0.2-0.1-0.3-0.8-0.40.0-0.2-0.1
Progressive ratio0.60.72.21.51.2-0.91.3-0.9-0.8-0.70.7-0.40.5-0.2-0.3
Food seeking constrained by brief footshock0.30.41.0-0.4-0.40.4-0.30.30.70.7-0.50.7-0.71.00.8
Seeking ratio, punishment vs. effort1.01.22.9-1.7-1.41.1-1.41.01.21.0-0.81.0-0.90.80.7
Retroperitoneal fat weight0.51.84.22.11.6-1.31.7-1.5-1.3-1.51.5-0.21.0-0.6-0.7
Reaction time number correct0.71.12.61.60.9-1.50.7-1.0-1.1-0.70.5-1.30.8-0.9-0.6
Reaction time mean minus median0.50.61.6-0.00.8-0.70.7-0.5-0.7-0.6-0.3-1.31.0-0.8-1.1
Reaction time mean minus median AUC0.50.72.00.40.8-0.80.8-0.7-0.8-0.80.2-1.41.0-0.8-1.0
Reaction time num false alarms0.30.41.30.5-0.0-0.4-0.2-0.20.41.10.10.5-0.71.11.0
Reaction time num false alarms AUC0.20.20.80.40.1-0.6-0.1-0.40.20.90.30.5-0.40.80.6
Reaction time trials correct on left0.71.12.61.60.9-1.50.7-1.0-1.1-0.70.5-1.30.8-0.9-0.6
Reaction time trials on left0.71.12.51.61.0-1.50.7-1.0-1.1-0.60.4-1.30.8-0.9-0.6
Reaction time mean0.20.20.7-0.8-0.30.4-0.30.40.40.6-0.8-0.5-0.20.50.2
Reaction time mean AUC0.30.51.1-0.9-0.50.6-0.50.60.60.8-1.1-0.5-0.50.70.4
Median of all reaction times0.20.30.6-0.8-0.50.6-0.40.50.60.6-0.7-0.4-0.40.50.4
Reaction time omissions1.31.84.00.41.3-1.51.3-1.1-1.4-1.10.3-2.01.7-1.4-1.7
Reaction time false alarm rate0.40.51.6-0.3-0.30.2-0.30.10.71.10.01.1-0.81.30.9
Reaction time premature initiation rate0.20.20.9-0.40.1-0.10.10.20.41.00.00.8-0.20.70.3
Reaction time premature initiations0.10.20.60.40.6-0.80.4-0.3-0.20.60.2-0.00.20.30.0
Std. dev. reaction times0.30.40.9-0.30.7-0.70.6-0.4-0.5-0.3-0.4-1.00.9-0.5-0.9
Reaction time trials completed0.71.12.51.61.0-1.50.7-1.0-1.1-0.60.4-1.30.8-0.9-0.6
Reaction time trials AUC0.60.92.51.60.8-1.40.6-1.0-1.0-0.60.4-1.20.6-0.8-0.5
Run reversals in cocaine runway, females0.80.71.2-0.5-0.90.8-1.11.00.91.0-0.70.4-1.00.71.0
Run reversals in cocaine runway, males2.52.53.3-1.6-1.61.8-1.61.41.71.6-1.01.4-1.61.81.6
Latency to leave start box in cocaine runway4.24.55.52.02.1-2.21.9-1.9-2.3-2.12.1-2.02.2-2.4-2.2
Latency to leave start box in cocaine runway, F5.56.08.22.12.4-2.32.2-2.2-2.6-2.62.1-2.72.6-2.9-2.6
Latency to leave start box in cocaine runway, M0.50.41.10.50.6-1.10.6-0.3-0.7-0.31.0-0.10.7-0.6-0.7
Std. dev. time between licks in bursts0.20.30.5-0.6-0.70.6-0.60.60.60.5-0.20.4-0.60.40.5
Total sessions with >9 infusions0.20.20.6-0.7-0.80.4-0.70.30.40.2-0.20.4-0.20.00.1
Short access day 1 total inactive lever presses3.23.57.71.51.4-1.01.4-1.7-1.9-2.81.6-2.21.9-2.4-2.0
Short access day 10 total inactive lever presses0.20.31.0-0.20.30.4-0.1-0.2-0.4-1.00.3-0.50.5-0.7-0.7
Short access day 1 total infusions0.40.51.1-0.7-1.01.0-0.90.40.70.1-0.40.7-0.60.40.5
Short access day 10 total infusions0.20.20.9-0.7-0.40.3-0.40.20.30.1-0.90.5-0.10.1-0.0
Short access total infusions0.10.10.3-0.5-0.50.4-0.5-0.10.1-0.4-0.40.40.0-0.1-0.1
Short access day 1 locomotion0.10.10.5-0.2-0.3-0.2-0.3-0.1-0.3-0.40.4-0.00.3-0.7-0.5
Short access day 10 total locomotion0.20.21.1-0.2-0.50.5-0.60.30.40.1-0.21.1-0.40.40.4
Short access total locomotion0.20.20.8-0.9-0.60.3-0.60.20.0-0.4-0.10.10.3-0.6-0.5
One hour access (0.3 mA shock)0.50.50.90.70.8-0.90.6-0.8-0.8-0.50.4-0.90.7-0.7-0.7
Compulsive drug intake3.63.75.32.02.2-1.52.1-2.2-2.0-2.31.7-1.41.9-1.6-1.8
One hour access (shock baseline)0.20.20.5-0.20.1-0.70.1-0.4-0.4-0.20.2-0.70.6-0.7-0.7
Social response proportion1.61.73.11.21.4-1.31.3-1.0-1.4-1.20.3-1.41.4-1.8-1.4
Social responses2.12.74.60.61.5-1.21.4-1.5-1.7-1.81.2-1.72.0-2.2-2.1
Social time0.10.20.9-0.9-0.1-0.1-0.1-0.1-0.00.1-0.6-0.40.4-0.4-0.6
Soleus weight0.82.45.41.31.6-1.61.5-1.3-1.6-1.40.8-2.31.6-1.7-1.7
Bone: stiffness0.10.20.60.80.5-0.60.4-0.5-0.00.40.3-0.1-0.20.60.4
Tibialis anterior weight0.20.72.71.71.0-1.10.9-0.7-0.6-0.1-0.7-1.10.2-0.00.1
Time to tail flick, vehicle, before self-admin0.30.30.6-0.7-0.70.7-0.70.80.50.2-0.10.2-0.40.10.3
Time to tail flick, vehicle, after self-admin0.20.20.50.70.5-0.70.1-0.5-0.4-0.20.1-0.50.3-0.3-0.2
Time to tail flick, test, before self-admin1.31.33.20.51.0-0.80.9-0.9-1.1-1.31.8-0.81.3-1.4-1.4
Time to tail flick, test, after self-admin1.11.12.70.60.7-0.80.5-0.9-1.0-1.21.1-1.61.1-1.4-1.2
Delta time to tail flick, vehicle, before/after SA0.20.20.70.80.5-0.70.2-0.6-0.30.10.0-0.40.10.10.1
Delta time to tail flick, test, before/after SA0.10.10.40.3-0.30.0-0.20.10.10.2-0.6-0.3-0.30.30.4
Tibia length0.00.10.30.00.3-0.20.4-0.1-0.1-0.10.50.50.20.1-0.1
Ambulatory time before self-admin0.20.20.6-0.7-0.70.3-0.70.60.30.2-0.20.8-0.2-0.00.1
Ambulatory time after self-admin0.70.82.30.10.4-0.90.3-0.3-0.9-0.90.6-1.31.1-1.5-1.3
Bone: tissue strength0.20.20.40.20.5-0.30.4-0.5-0.5-0.60.5-0.40.6-0.6-0.6
Total heroin consumption0.20.31.3-0.4-0.21.00.3-0.70.0-1.20.00.50.2-0.1-0.3
Bone: trabecular number1.01.62.41.01.1-1.01.1-1.1-1.3-1.51.1-1.61.3-1.5-1.3
Bone: trabecular spacing0.20.20.6-0.5-0.30.3-0.40.40.50.7-0.40.2-0.40.80.5
Bone: trabecular thickness1.61.93.50.81.2-1.21.3-1.4-1.3-1.51.9-1.11.5-1.4-1.5
Bone: trabecular tissue density0.50.72.11.40.9-0.90.9-0.9-0.9-0.90.4-0.30.6-0.6-0.5
Water consumed over 24 hours0.30.30.9-0.9-0.60.4-0.50.70.40.7-0.9-0.6-0.30.00.1
Number of responses in last shaping day0.10.10.60.80.2-0.50.1-0.2-0.00.60.50.0-0.30.20.4