Hub : Genes

Engase

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Engase 0.1 0.08 4.1e-03 0.05 0.04 0.04 0.04 9.9e-04 2.2e-03 3.8e-03 1.9e-03
2 Liver gene expression Engase 0.03 0.02 4.2e-04 0.01 0.02 0.02 0 2.1e-02 3.0e-03 4.8e-03 1.9e-01
3 Brain gene expression Engase 0.26 0.14 4.2e-10 0.12 0.1 0.1 0.11 3.0e-11 6.2e-10 1.9e-09 4.0e-10
4 NAcc gene expression Engase 0.17 0.07 0.0e+00 0.13 0.13 0.13 0.13 1.3e-18 5.9e-19 1.2e-18 7.5e-19
5 IC gene expression Engase 0.14 0.09 9.5e-04 0.09 0.07 0.06 0.08 1.6e-04 9.3e-04 2.5e-03 2.6e-04
6 Brain isoform ratio XR_005489867.1 0.06 0.04 1.1e-03 0.02 0.03 0.02 0.03 4.4e-03 4.0e-04 2.4e-03 1.1e-03
7 PL gene expression Engase 0.21 0.09 0.0e+00 0.19 0.17 0.18 0.18 3.0e-20 3.0e-18 8.0e-19 9.9e-20
8 Brain alternative polyA XM_063269246.1 0.06 0.04 2.1e-03 0.01 0.02 0.01 0.01 3.8e-02 6.4e-03 4.8e-02 3.8e-02
9 Brain alternative polyA XM_006247803.3 0.06 0.04 1.9e-03 0.01 0.02 0.01 0.01 3.3e-02 5.3e-03 3.6e-02 2.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.33.94.61.8-1.92.02.12.12.02.11.9-1.8
Area under the delay curve0.20.30.9-0.21.00.20.10.20.2-0.80.6-0.6
BMI with tail2.06.910.4-3.20.9-2.5-2.5-2.5-2.8-2.1-3.23.2
BMI without tail0.20.72.0-1.4-0.3-0.7-0.5-0.7-0.7-0.1-1.01.0
Body weight1.98.215.0-3.92.2-2.7-2.7-2.7-2.9-2.5-2.92.9
Weight adjusted by age0.61.01.40.3-0.41.11.11.21.00.91.2-1.2
Bone surface2.34.15.82.1-0.52.22.02.22.11.62.4-2.4
Bone volume2.44.45.32.2-1.12.32.12.32.22.02.2-2.2
Breakpoint value in progressive ratio session0.80.91.51.0-0.81.21.11.21.00.40.8-0.8
Number of licking bursts0.10.10.3-0.50.3-0.3-0.3-0.3-0.30.2-0.30.3
Context. condit. distance diff. score0.10.20.40.60.00.50.40.50.40.20.4-0.4
Locomotion velocity, session 11.51.62.4-1.61.5-1.4-1.3-1.3-1.2-1.5-0.80.8
Locomotion distance, session 10.30.31.70.2-1.30.30.50.30.40.70.1-0.1
Locomotion velocity, session 20.10.10.40.2-0.70.20.30.20.30.20.1-0.1
Locomotion distance, session 21.11.55.50.5-2.30.91.31.01.11.50.7-0.7
Locomotion velocity, session 30.20.20.5-0.40.7-0.5-0.5-0.5-0.4-0.0-0.10.1
Locomotion distance, session 31.01.11.7-1.00.2-1.2-1.0-1.2-1.10.1-1.31.3
Stereotopy head waving bouts, day 30.50.51.6-0.41.1-0.5-0.7-0.5-0.6-1.3-0.50.5
Stereotopy head waving duration, day 30.10.20.70.10.9-0.0-0.20.0-0.1-0.90.0-0.1
Locomotion velocity, session 70.50.61.00.6-0.20.80.80.80.80.11.0-1.0
Locomotion distance, session 72.93.75.01.7-2.22.02.22.12.01.71.7-1.7
Stereotopy head waving bouts, day 71.11.23.4-0.41.8-1.0-1.2-1.0-1.1-1.2-0.80.8
Stereotopy head waving duration, day 71.01.24.7-0.32.2-1.0-1.3-1.0-1.0-1.1-0.60.6
Locomotion velocity, session 80.50.61.30.80.40.70.60.80.8-0.51.1-1.1
Locomotion distance, session 81.82.64.51.3-2.11.61.71.71.61.71.2-1.2
Degree of sensitization distance8.78.910.92.8-2.53.33.23.33.22.23.1-3.1
Degree of sensitization stereotypy0.40.51.3-0.11.1-0.7-0.8-0.7-0.7-0.5-0.60.5
Conditioned locomotion0.50.60.80.8-0.80.90.80.80.80.80.7-0.7
Cocaine response after cond. corrected0.20.20.3-0.40.4-0.4-0.4-0.5-0.5-0.4-0.50.5
Cocaine response after cond. not corrected0.00.00.1-0.10.20.10.10.00.1-0.00.2-0.2
Cocaine response before conditioning1.31.52.80.9-0.41.11.31.31.40.81.7-1.7
Saline control response0.30.41.20.00.30.30.40.30.6-0.31.1-1.1
Bone: connectivity density3.35.25.92.1-1.82.32.42.32.42.22.4-2.4
Bone: cortical apparent density0.20.31.2-0.2-1.1-0.3-0.1-0.3-0.30.5-0.70.7
Bone: cortical area6.49.911.5-3.42.6-3.2-3.2-3.2-3.3-2.9-3.23.2
Bone: cortical porosity0.50.51.5-0.51.2-0.5-0.7-0.7-0.5-1.1-0.20.2
Bone: cortical porosity0.60.62.3-0.51.5-0.5-0.7-0.7-0.6-1.3-0.20.2
Bone: cortical thickness12.721.126.9-5.22.4-4.9-4.6-4.9-4.8-3.9-5.05.0
Bone: cortical thickness6.37.59.5-3.01.3-2.9-2.8-2.9-2.9-2.2-3.13.1
Bone: cortical tissue density0.20.31.4-0.1-1.2-0.10.0-0.1-0.10.6-0.60.6
Condit. Reinf. active minus inactive responses0.40.51.01.0-0.50.80.70.70.70.30.7-0.7
Condit. Reinf. active-inactive response ratio2.02.12.81.7-1.01.51.41.51.51.41.5-1.5
Condit. Reinf. active responses0.40.40.70.8-0.70.70.60.70.70.20.7-0.7
Condit. Reinf. inactive responses0.00.00.20.1-0.40.10.10.10.1-0.3-0.00.0
Incentive salience index mean0.20.30.91.0-0.30.50.40.50.50.30.5-0.5
Condit. Reinf. lever presses0.10.20.50.7-0.40.30.30.30.30.50.3-0.3
Condit. Reinf. active minus inactive responses0.20.30.70.50.30.50.50.40.60.20.8-0.9
Condit. Reinf. active-inactive response ratio0.10.10.2-0.10.50.00.10.00.1-0.30.4-0.4
Condit. Reinf. active responses1.01.51.71.2-0.81.31.31.21.31.11.3-1.3
Condit. Reinf. inactive responses1.72.22.81.7-1.41.51.51.51.51.61.3-1.3
Condit. Reinf. lever presses2.94.04.52.1-1.82.12.12.12.02.01.9-1.9
Condit. Reinf. lever reinforcers received1.31.82.01.4-1.21.41.41.41.31.41.2-1.2
Conditioned reinforcement - actives0.10.10.80.0-0.90.10.10.1-0.10.0-0.40.4
Conditioned reinforcement - inactives0.20.30.4-0.30.3-0.5-0.6-0.6-0.6-0.4-0.60.6
Conditioned locomotion0.40.52.00.5-1.40.70.80.70.60.60.2-0.2
Patch foraging indifference point 0 sec1.22.23.51.7-1.81.51.41.51.41.91.0-1.0
Patch foraging indifference point AUC1.41.92.91.1-1.01.51.51.31.61.01.7-1.7
Delay disc. indifference point, 0s delay0.70.82.3-1.01.4-0.6-0.7-0.7-0.6-1.5-0.10.1
Delay disc. indifference point, 16s delay0.60.70.90.8-0.60.90.90.90.90.60.9-0.9
Delay disc. indifference point, 2s delay0.20.20.7-0.50.60.20.10.20.2-0.90.5-0.5
Delay disc. indifference point, 24s delay0.10.10.2-0.0-0.00.20.20.10.20.50.3-0.3
Delay disc. indifference point, 4s delay0.40.52.0-0.61.2-0.1-0.2-0.2-0.1-1.40.4-0.4
Delay disc. indifference point, 8s delay0.80.94.4-0.82.1-0.6-0.8-0.6-0.6-1.30.0-0.1
Indifference point function ln k1.12.04.1-1.00.1-1.4-1.4-1.3-1.6-0.8-2.02.0
Indifference point function log k1.12.04.1-1.00.1-1.4-1.4-1.3-1.6-0.8-2.02.0
Patch foraging total patch changes 0 sec1.32.43.91.8-2.01.51.51.51.42.01.0-1.0
Patch foraging total patch changes 12 sec2.02.64.01.4-2.01.61.81.61.71.71.5-1.4
Patch foraging total patch changes 18 sec5.07.68.82.9-2.43.02.82.92.82.72.6-2.6
Patch foraging total patch changes 24 sec0.61.01.81.3-0.11.10.91.01.10.61.2-1.2
Patch foraging total patch changes 6 sec1.01.62.70.9-1.61.31.31.31.21.51.0-1.0
Patch foraging time to switch 0 sec0.00.10.3-0.10.5-0.2-0.2-0.2-0.1-0.4-0.00.0
Patch foraging water rate 0 sec0.30.71.40.5-1.00.90.90.80.81.20.7-0.7
Patch foraging water rate 12 sec0.51.02.5-0.4-0.5-1.0-0.9-1.0-1.0-0.4-1.61.6
Patch foraging water rate 18 sec0.20.40.90.6-0.90.60.60.60.50.70.2-0.2
Patch foraging water rate 24 sec1.72.43.61.9-1.91.61.61.51.51.61.1-1.1
Patch foraging water rate 6 sec1.21.72.6-1.40.2-1.4-1.2-1.4-1.3-1.1-1.61.6
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.80.3-0.3-0.1-0.0-0.00.50.1-0.1
Distance traveled before self-admin0.20.20.7-0.40.9-0.5-0.5-0.4-0.4-0.5-0.20.2
Distance traveled after self-admin2.73.44.02.0-1.91.82.02.01.81.81.6-1.6
Extensor digitorum longus weight0.20.83.60.5-1.90.70.60.50.41.3-0.10.1
Bone: elastic displacement0.91.11.9-1.2-0.4-1.0-0.9-1.1-1.0-0.5-1.31.4
Bone: elastic work3.84.96.2-2.51.1-2.3-2.2-2.4-2.3-1.7-2.52.5
Bone: endosteal estimation2.75.88.12.8-0.72.82.42.82.42.02.5-2.6
Bone: endosteal perimeter1.02.23.51.71.11.61.11.61.30.71.8-1.9
Epididymis fat weight0.10.30.9-1.0-0.1-0.3-0.2-0.2-0.5-0.1-0.70.7
Delta time in closed arm before/after self-admin1.11.01.51.0-0.41.01.11.11.10.71.2-1.2
Delta time in open arm before/after self-admin0.20.21.00.5-0.70.40.30.20.31.00.2-0.2
Diff in mean of infusions in LGA sessions0.81.01.60.9-0.21.21.11.31.1-0.21.1-1.1
Delay discount exponential model param0.30.31.20.3-1.1-0.10.0-0.1-0.10.9-0.50.5
Extinction: sum of active levers before priming0.10.10.20.3-0.50.0-0.0-0.0-0.10.1-0.40.4
Active lever presses in extinction session 60.20.20.4-0.0-0.60.60.50.60.40.40.3-0.3
Bone: final force2.64.15.7-2.41.8-2.1-2.0-2.1-2.0-2.0-1.91.9
Bone: final moment2.64.25.5-2.31.8-2.1-2.0-2.1-2.1-2.1-1.91.9
Food consumed during 24 hour testing period0.91.32.11.4-0.11.11.01.11.20.71.4-1.4
Glucose1.93.13.9-1.71.2-1.8-1.8-1.8-1.9-1.4-2.02.0
Heart weight4.77.39.3-2.81.5-2.9-2.7-2.8-2.9-2.4-3.03.0
Delay discount hyperbolic model param0.30.31.30.4-1.20.00.10.10.01.1-0.40.4
Intermittent access intake day 1-15 change0.20.30.8-0.20.9-0.7-0.7-0.7-0.6-0.4-0.40.4
Intermittent access intake escalation0.20.50.7-0.50.8-0.8-0.9-0.8-0.7-0.5-0.60.6
Intermittent access intake escalation 20.10.20.4-0.50.7-0.4-0.4-0.4-0.3-0.3-0.20.2
Intermitt. access day 1 inactive lever presses0.00.21.31.10.20.0-0.20.1-0.1-0.1-0.10.1
Intermitt. access day 15 inactive lever presses0.30.71.21.1-0.70.90.70.80.80.90.7-0.7
Intermitt. access escalation Index0.20.31.11.10.20.40.20.40.50.60.6-0.6
Intermittent access day 1 total infusions0.20.31.0-0.2-0.5-0.3-0.4-0.5-0.6-0.1-1.01.0
Intermittent access day 15 total infusions0.10.10.3-0.1-0.1-0.3-0.4-0.5-0.4-0.1-0.50.5
Intermittent access terminal intake (last 3 days)0.10.10.2-0.00.2-0.2-0.4-0.3-0.4-0.2-0.50.5
Intermittent access total infusions0.20.20.6-0.2-0.1-0.3-0.4-0.4-0.5-0.3-0.80.8
Intermittent access day 1 locomotion0.40.51.50.2-1.20.70.80.60.60.80.3-0.3
Intermittent access day 15 total locomotion0.20.30.6-0.70.0-0.4-0.5-0.6-0.6-0.0-0.70.7
Intermittent access total locomotion0.10.10.3-0.3-0.50.00.0-0.1-0.20.2-0.40.4
Intermittent access standard deviation2.45.06.5-2.02.5-2.2-2.3-2.0-2.3-2.4-2.12.1
Left kidney weight1.36.29.4-3.12.6-2.4-2.5-2.5-2.5-2.4-2.22.2
Right kidney weight1.04.47.6-2.71.6-2.1-2.0-2.1-2.2-1.7-2.12.1
Cocaine induced anxiety1.01.42.6-1.31.3-1.3-1.1-1.3-1.1-1.6-0.70.7
Post-drug Anxiety1.41.53.9-1.10.8-1.3-1.1-1.3-1.1-2.0-1.11.1
Baseline Anxiety0.50.61.10.7-1.00.90.81.00.70.70.4-0.4
Tail length0.20.82.00.10.30.80.90.80.90.81.4-1.4
Length with tail0.62.56.0-2.42.5-1.3-1.3-1.4-1.3-1.5-0.70.7
Length without tail2.68.413.2-3.63.0-2.7-2.9-2.7-2.9-2.8-2.72.6
Times rat made contact with spout0.80.91.21.1-0.70.90.91.01.00.81.0-1.0
Lifetime Intake0.20.30.7-0.2-0.1-0.3-0.5-0.5-0.6-0.5-0.80.8
Liver weight, left0.71.11.9-0.81.3-0.9-1.1-1.1-1.1-1.4-0.90.9
Liver weight, right0.10.21.2-0.31.1-0.2-0.4-0.3-0.3-0.6-0.00.0
Locomotor activity0.00.10.1-0.3-0.20.30.20.30.2-0.00.2-0.2
Locomotor testing distance0.51.01.40.6-0.81.21.11.21.00.91.0-1.0
Locomotor testing rearing1.32.63.01.6-1.51.71.71.51.71.31.7-1.7
Locomotion in novel chamber3.44.35.72.1-1.22.22.22.22.31.52.4-2.4
Locomotion in novel chamber post-restriction1.11.92.91.7-0.41.61.31.51.40.91.5-1.5
Fecal boli incidents, locomotor time 10.40.61.20.7-1.11.10.80.90.70.70.4-0.4
Change in fecal boli incidents, locomotor task0.20.20.6-0.10.0-0.5-0.4-0.5-0.5-0.8-0.60.6
Time >=10cm from walls, locomotor time 11.01.11.91.4-0.21.00.91.01.10.71.2-1.2
Bouts of movement, locomotor time 10.60.61.2-0.40.1-0.7-0.9-0.9-0.8-0.8-1.11.1
Total resting periods, locomotor time 10.40.51.0-0.2-0.1-0.5-0.7-0.7-0.7-0.7-1.01.0
Rest time, locomotor task time 11.72.13.1-1.30.7-1.4-1.5-1.4-1.6-1.5-1.81.8
Distance moved, locomotor task time 10.60.91.50.8-0.30.80.90.91.01.11.2-1.2
Vertical activity count, locomotor time 10.81.92.40.9-1.01.31.51.41.51.51.5-1.5
Time >=10cm from walls, locomotor time 20.00.00.1-0.3-0.1-0.3-0.1-0.2-0.1-0.1-0.10.1
Bouts of movement, locomotor time 20.00.00.10.20.00.2-0.00.0-0.00.2-0.10.1
Total resting periods, locomotor time 20.00.10.20.4-0.10.40.20.30.20.40.1-0.1
Rest time, locomotor task time 20.00.10.20.20.10.30.10.30.1-0.5-0.0-0.0
Distance moved, locomotor task time 20.50.61.5-1.20.4-0.9-0.7-0.8-0.7-0.4-0.60.6
Vertical activity count, locomotor time 20.20.30.9-0.9-0.0-0.6-0.4-0.4-0.50.1-0.60.6
Light reinforcement 10.61.53.21.3-1.81.11.21.11.21.40.9-0.9
Light reinforcement 20.00.00.1-0.30.1-0.2-0.1-0.1-0.1-0.3-0.00.0
Bone: marrow area2.65.77.92.8-0.62.82.32.82.41.92.5-2.5
Bone: maximum diameter1.32.57.8-1.32.8-1.2-1.6-1.2-1.4-1.9-1.01.0
Bone: maximum force1.62.83.8-2.01.5-1.7-1.6-1.7-1.7-1.6-1.71.6
Bone: maximum moment1.72.93.6-1.91.5-1.7-1.7-1.7-1.8-1.7-1.71.7
Mean time between licks in bursts0.00.10.2-0.50.3-0.5-0.3-0.3-0.3-0.1-0.30.3
Mean num. licks in bursts0.50.91.61.3-1.10.91.00.90.90.30.8-0.8
Cd content in liver0.30.31.70.6-1.30.30.30.30.20.4-0.30.3
Co content in liver0.10.10.30.4-0.2-0.1-0.1-0.1-0.1-0.5-0.20.2
Cu content in liver0.00.00.1-0.10.3-0.2-0.2-0.2-0.1-0.2-0.00.0
Fe content in liver1.62.03.11.7-0.61.51.41.51.50.91.6-1.6
K content in liver0.70.71.21.1-0.50.80.80.80.90.21.0-1.0
Mg content in liver2.92.93.41.8-1.81.71.81.71.81.61.6-1.6
Mn content in liver0.10.10.3-0.30.5-0.2-0.2-0.2-0.1-0.50.1-0.1
Na content in liver0.50.50.90.8-0.20.70.70.70.80.20.9-0.9
Rb content in liver0.91.01.60.8-1.21.01.11.01.01.30.9-0.8
Se content in liver2.12.53.21.3-1.21.61.71.61.71.51.8-1.8
Sr content in liver0.50.40.7-0.60.1-0.7-0.7-0.7-0.7-0.1-0.80.9
Zn content in liver0.20.20.3-0.30.3-0.4-0.5-0.4-0.5-0.2-0.50.5
Bone: minimum diameter0.10.21.80.11.30.0-0.4-0.0-0.2-0.50.1-0.1
Time in familiar zone, hab. session 10.10.10.20.5-0.2-0.1-0.2-0.1-0.1-0.3-0.30.3
Time in novel zone, hab. session 10.10.10.5-0.50.7-0.2-0.1-0.1-0.1-0.40.2-0.2
Total zone transitions, hab. session 10.81.22.20.8-1.50.91.11.01.11.40.9-0.9
Total locomotion distance, hab. session 10.50.71.70.5-1.30.70.90.70.81.30.6-0.5
Locomotion velocity, hab. session 10.60.92.60.5-1.50.70.90.70.81.60.5-0.5
Time in familiar zone, hab. session 20.10.10.50.1-0.30.00.10.1-0.0-0.7-0.10.1
Time in novel zone, hab. session 20.10.10.30.10.5-0.1-0.2-0.1-0.10.60.1-0.1
Total zone transitions, hab. session 22.93.67.81.5-2.81.82.11.91.91.91.5-1.4
Total locomotion distance, hab. session 21.72.26.61.0-2.61.31.51.21.31.80.8-0.8
Locomotion velocity, hab. session 21.62.16.40.9-2.51.31.51.21.31.80.8-0.8
Novel to familiar place preference ratio1.92.13.61.5-1.91.41.51.41.41.61.0-1.0
Novelty place preference1.71.92.91.5-1.71.31.41.41.31.51.0-1.0
Time in novel zone, NPP test1.81.93.31.5-1.81.31.41.41.41.51.0-1.0
Total zone transitions, NPP test1.42.04.61.0-2.11.21.51.31.41.51.1-1.1
Total locomotion distance, NPP test1.52.17.60.9-2.81.01.41.01.12.10.5-0.5
Locomotion velocity, NPP test1.41.96.70.9-2.61.01.41.11.12.00.6-0.5
Intraocular pressure2.33.34.22.0-1.72.01.82.01.72.01.4-1.4
Delta distance traveled before/after self-admin1.92.03.61.3-1.91.41.51.41.41.61.0-1.0
Delta ambulatory time before/after self-admin2.53.14.71.8-2.21.71.91.71.71.91.4-1.4
Parametrial fat weight0.00.10.20.3-0.30.40.20.20.20.40.0-0.0
Pavlov. Cond. lever latency2.32.93.61.9-1.31.91.81.91.71.41.6-1.6
Pavlov. Cond. magazine entry latency0.70.93.0-0.71.7-0.8-0.9-0.8-0.8-1.1-0.30.3
Pavlov. Cond. change in total contacts0.40.40.8-0.6-0.3-0.7-0.6-0.7-0.7-0.5-0.90.9
Pavlov. Cond. index score1.31.62.3-1.21.5-1.3-1.3-1.3-1.2-1.3-1.01.0
Pavlov. Cond. latency score2.02.63.4-1.61.8-1.7-1.7-1.7-1.6-1.5-1.31.3
Pavlov. Cond. lever contacts1.41.62.0-1.20.7-1.4-1.4-1.4-1.3-1.1-1.41.4
Pavlov. Cond. magazine entry number1.21.53.41.1-1.81.21.31.31.21.20.8-0.8
Pavlov. Cond. intertrial magazine entries1.92.23.11.7-1.81.51.51.51.51.51.2-1.2
Pavlov. Cond. lever-magazine prob. diff.0.91.11.5-1.01.2-1.2-1.1-1.2-1.1-1.0-0.90.9
Pavlov. Cond. response bias1.21.52.1-1.11.5-1.3-1.3-1.3-1.2-1.3-1.01.0
Pavlov. Cond. lever latency3.75.06.5-2.51.8-2.4-2.2-2.4-2.3-2.1-2.22.2
Pavlov. Cond. magazine entry latency0.40.51.21.1-1.10.70.60.70.50.80.1-0.1
Pavlov. Cond. change in total contacts1.82.94.62.1-1.91.81.61.71.61.81.2-1.2
Pavlov. Cond. index score1.82.44.02.0-1.61.71.51.71.51.51.1-1.1
Pavlov. Cond. latency score1.62.24.02.0-1.41.61.41.61.41.41.1-1.1
Pavlov. Cond. lever contacts4.15.67.32.7-2.02.52.42.52.42.32.2-2.2
Pavlov. Cond. magazine entry number0.81.02.5-1.61.2-1.0-0.8-1.0-0.8-1.1-0.40.4
Pavlov. Cond. intertrial magazine entries2.43.76.11.5-0.62.02.01.92.11.52.5-2.5
Pavlov. Cond. lever-magazine prob. diff.1.92.64.52.1-1.61.71.51.71.51.61.2-1.2
Pavlov. Cond. response bias2.12.94.32.1-1.91.71.71.81.61.81.3-1.3
Time in closed arm before self-admin1.72.24.3-2.10.8-1.6-1.5-1.5-1.5-0.9-1.61.6
Time in closed arm after self-admin0.80.81.1-0.80.7-1.0-0.9-0.8-0.9-1.0-1.01.0
Time in open arm before self-admin0.20.20.50.2-0.00.50.50.50.50.10.7-0.7
Time in open arm after self-admin1.41.51.81.3-1.11.41.21.21.21.41.2-1.2
Bone: periosteal estimation0.10.31.7-0.31.3-0.2-0.5-0.2-0.5-0.6-0.30.3
Bone: periosteal perimeter3.05.19.7-2.33.1-2.1-2.4-2.1-2.2-2.4-1.81.8
Bone: post-yield work0.60.91.41.1-1.10.90.91.00.81.20.6-0.6
Progressive ratio test 1 active lever presses0.20.30.70.7-0.80.60.50.40.40.80.2-0.2
Progressive ratio test 1 breakpoint0.30.30.70.7-0.80.60.50.50.50.80.2-0.2
Progressive ratio test 1 inactive lever presses0.10.10.70.8-0.20.40.20.40.30.20.3-0.3
Progressive ratio test 2 active lever presses0.20.21.10.1-0.80.30.20.10.11.0-0.20.3
Progressive ratio test 2 breakpoint0.20.20.90.0-0.70.10.1-0.0-0.10.9-0.40.4
Progressive ratio test 2 inactive lever presses0.20.30.4-0.40.2-0.5-0.5-0.6-0.60.1-0.70.7
Incentive Sensitization - Responses0.50.71.1-0.70.5-0.7-1.0-0.8-0.9-0.2-1.01.0
Incentive Sensitization - Breakpoint0.60.81.3-0.70.6-0.8-1.1-0.9-1.0-0.2-1.11.1
Sum of active levers in priming session hrs 5-60.10.10.20.4-0.40.30.20.30.1-0.1-0.10.1
Progressive ratio0.10.20.7-0.2-0.4-0.2-0.3-0.1-0.4-0.3-0.80.8
Food seeking constrained by brief footshock1.31.61.8-1.11.0-1.3-1.3-1.2-1.3-1.3-1.41.3
Seeking ratio, punishment vs. effort0.10.10.6-0.00.8-0.4-0.3-0.4-0.2-0.30.1-0.1
Retroperitoneal fat weight0.31.41.90.8-0.51.41.31.31.21.21.3-1.3
Reaction time number correct3.46.57.42.7-2.52.72.62.62.62.32.4-2.4
Reaction time mean minus median0.71.82.3-1.21.1-1.4-1.4-1.5-1.4-1.4-1.31.3
Reaction time mean minus median AUC0.51.32.3-0.91.4-1.1-1.2-1.2-1.1-1.5-0.80.8
Reaction time num false alarms0.00.10.20.1-0.20.20.10.30.10.5-0.00.0
Reaction time num false alarms AUC0.20.40.80.4-0.60.60.60.80.50.90.4-0.4
Reaction time trials correct on left3.46.57.42.7-2.52.72.62.62.62.32.4-2.4
Reaction time trials on left3.46.57.32.7-2.42.72.62.62.62.32.4-2.4
Reaction time mean0.10.10.2-0.30.1-0.3-0.3-0.4-0.3-0.4-0.40.4
Reaction time mean AUC0.10.10.2-0.3-0.0-0.3-0.3-0.3-0.3-0.4-0.40.4
Median of all reaction times0.00.00.0-0.1-0.1-0.1-0.0-0.0-0.1-0.2-0.10.1
Reaction time omissions0.81.11.8-1.21.3-1.0-1.0-1.1-1.0-1.3-0.80.7
Reaction time false alarm rate0.50.61.0-1.00.7-0.8-0.8-0.6-0.9-0.4-0.90.9
Reaction time premature initiation rate0.40.63.20.1-1.80.30.60.40.41.0-0.00.1
Reaction time premature initiations2.34.19.31.7-3.01.92.11.91.92.31.4-1.4
Std. dev. reaction times0.30.50.7-0.50.3-0.7-0.7-0.8-0.7-0.8-0.80.8
Reaction time trials completed3.46.57.32.7-2.42.72.62.62.62.32.4-2.4
Reaction time trials AUC3.77.17.92.8-2.62.82.82.72.72.52.5-2.5
Run reversals in cocaine runway, females0.10.10.30.20.3-0.1-0.5-0.3-0.40.1-0.60.6
Run reversals in cocaine runway, males0.90.91.8-1.20.2-0.8-0.7-0.9-1.0-1.3-1.11.1
Latency to leave start box in cocaine runway0.10.10.2-0.3-0.50.1-0.1-0.0-0.20.0-0.40.4
Latency to leave start box in cocaine runway, F0.20.20.60.2-0.70.50.40.50.30.40.1-0.1
Latency to leave start box in cocaine runway, M0.20.20.4-0.5-0.3-0.3-0.2-0.3-0.4-0.0-0.60.6
Std. dev. time between licks in bursts2.23.03.51.6-1.61.81.91.91.91.31.8-1.8
Total sessions with >9 infusions0.50.61.4-0.30.3-0.5-0.8-0.7-0.9-0.8-1.21.2
Short access day 1 total inactive lever presses0.30.41.3-0.51.0-0.3-0.6-0.3-0.6-1.2-0.40.4
Short access day 10 total inactive lever presses0.10.30.60.50.70.40.10.40.4-0.10.8-0.8
Short access day 1 total infusions0.40.51.1-0.20.3-0.4-0.8-0.7-0.8-0.7-1.11.0
Short access day 10 total infusions0.10.10.30.60.00.40.00.1-0.0-0.1-0.20.2
Short access total infusions0.20.20.60.1-0.1-0.1-0.4-0.3-0.5-0.5-0.80.8
Short access day 1 locomotion0.40.50.8-0.80.4-0.6-0.7-0.7-0.8-0.6-0.90.9
Short access day 10 total locomotion0.10.30.5-0.60.5-0.4-0.5-0.4-0.5-0.7-0.60.5
Short access total locomotion1.51.72.3-1.30.9-1.1-1.3-1.3-1.4-1.5-1.51.5
One hour access (0.3 mA shock)0.20.20.90.6-0.90.30.20.30.10.3-0.30.3
Compulsive drug intake0.40.50.80.8-0.70.70.70.70.70.90.7-0.7
One hour access (shock baseline)0.00.00.10.0-0.1-0.1-0.2-0.1-0.2-0.2-0.40.4
Social response proportion0.10.10.2-0.4-0.3-0.2-0.2-0.2-0.30.0-0.50.5
Social responses0.20.20.4-0.50.2-0.5-0.5-0.7-0.5-0.5-0.50.5
Social time0.20.30.7-0.5-0.2-0.6-0.5-0.5-0.6-0.1-0.80.8
Soleus weight0.30.81.3-1.2-0.3-0.9-0.8-1.0-0.9-0.5-1.11.2
Bone: stiffness1.93.13.8-1.91.7-1.8-1.7-1.8-1.8-1.8-1.71.7
Tibialis anterior weight0.10.41.0-0.5-0.4-0.5-0.6-0.7-0.7-0.2-1.01.0
Time to tail flick, vehicle, before self-admin0.10.10.1-0.3-0.0-0.2-0.3-0.4-0.2-0.2-0.30.3
Time to tail flick, vehicle, after self-admin2.43.23.9-1.51.5-1.9-2.0-1.9-2.0-1.1-2.02.0
Time to tail flick, test, before self-admin1.51.52.10.7-0.81.31.31.21.31.21.4-1.4
Time to tail flick, test, after self-admin1.01.12.2-1.21.5-0.8-1.0-0.9-1.0-1.3-0.70.7
Delta time to tail flick, vehicle, before/after SA0.10.10.20.20.4-0.2-0.3-0.2-0.30.4-0.30.3
Delta time to tail flick, test, before/after SA4.14.24.9-1.92.1-2.0-2.1-2.1-2.1-2.2-1.91.9
Tibia length9.526.145.2-5.46.7-5.0-5.1-5.0-4.9-5.9-3.73.6
Ambulatory time before self-admin0.81.22.1-1.01.4-1.1-1.1-1.0-1.1-1.2-0.80.8
Ambulatory time after self-admin1.31.51.81.3-1.31.21.41.41.31.21.1-1.1
Bone: tissue strength0.20.20.70.5-0.80.30.30.30.30.70.0-0.0
Total heroin consumption0.20.20.9-0.31.0-0.2-0.4-0.3-0.3-0.6-0.20.2
Bone: trabecular number0.81.31.81.1-0.81.21.21.11.21.01.3-1.3
Bone: trabecular spacing0.20.30.6-0.40.5-0.5-0.6-0.5-0.6-0.8-0.60.6
Bone: trabecular thickness0.91.11.61.0-1.01.11.01.11.11.21.0-1.0
Bone: trabecular tissue density0.20.30.8-0.90.7-0.5-0.6-0.5-0.6-0.5-0.50.5
Water consumed over 24 hours0.10.20.30.4-0.30.30.40.40.50.40.5-0.5
Number of responses in last shaping day1.61.72.1-1.31.1-1.1-1.4-1.3-1.4-0.9-1.51.5