Hub : Genes

Endov

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Endov 0.09 0.06 8.0e-07 0.05 0.06 0.05 0.05 2.5e-06 2.8e-07 2.1e-06 2.6e-06
2 PL isoform ratio XM_056984678.2 0.07 0.04 1.0e-08 0.08 0.06 0.08 0.02 4.0e-09 2.7e-07 5.2e-09 1.4e-03
3 PL isoform ratio XM_063269672.1 0.06 0.04 8.7e-08 0.04 0.06 0.06 0.06 1.5e-05 3.7e-07 5.3e-07 5.5e-07
4 NAcc gene expression Endov 0.02 0.01 2.3e-03 0.01 0.01 0.01 0.01 2.2e-03 2.6e-03 2.1e-03 1.8e-03
5 IC isoform ratio XM_063269672.1 0.14 0.09 1.6e-03 0.02 0.05 0.03 0.06 5.1e-02 3.1e-03 2.6e-02 1.4e-03
6 Adipose gene expression Endov 0.04 0.03 3.3e-04 0.02 0.03 0.03 0.03 4.0e-03 1.6e-04 1.2e-04 2.8e-04
7 pVTA gene expression Endov 0.04 0.03 3.1e-03 0.03 0.01 0.01 0.02 8.9e-04 2.1e-02 4.2e-02 7.0e-03
8 PL alternative polyA XM_063269672.1 0.04 0.03 1.5e-03 0.01 0.01 0.01 0.01 1.1e-02 1.2e-02 7.6e-03 3.4e-02
9 PL alternative polyA NM_001402063.1 0.04 0.03 9.9e-04 0.01 0.01 0.01 0.01 2.6e-02 8.9e-03 7.6e-03 3.0e-02
10 PL alternative polyA NM_001402063.1 0.05 0.03 9.4e-05 0.04 0.03 0.03 0.03 7.3e-05 5.9e-04 2.0e-04 2.9e-04
11 PL alternative polyA XM_063269672.1 0.05 0.03 1.5e-04 0.04 0.02 0.03 0.03 9.4e-05 9.7e-04 2.0e-04 4.4e-04
12 NAcc alternative polyA NM_001402063.1 0.02 0.02 2.9e-03 0 0.01 0.01 0 4.4e-02 3.5e-03 3.2e-02 4.7e-02
13 NAcc alternative polyA XM_063269672.1 0.02 0.01 4.3e-03 0 0.01 0.01 0 7.2e-02 5.1e-03 4.2e-02 8.8e-02
14 NAcc alternative polyA NM_001402063.1 0.02 0.01 4.2e-03 -0 0.01 0 0 4.3e-01 5.5e-03 7.5e-02 1.2e-01
15 NAcc alternative polyA XM_063269672.1 0.02 0.01 2.9e-03 -0 0.01 0 0 4.2e-01 4.0e-03 7.3e-02 1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.30.6-0.3-0.10.2-0.60.60.8-0.8-0.70.70.0-0.00.6-0.60.6-0.5
Area under the delay curve0.60.73.41.91.0-1.41.0-0.9-0.30.6-0.20.11.0-1.0-0.20.2-0.30.2
BMI with tail0.61.95.9-0.7-1.41.6-2.12.3-0.6-2.4-0.70.80.9-0.91.0-1.01.3-1.3
BMI without tail1.44.210.9-2.8-3.23.3-3.13.1-1.6-3.00.00.2-0.20.20.5-0.61.1-1.1
Body weight1.66.917.3-3.9-4.24.0-3.23.0-3.4-2.91.9-1.6-1.91.9-1.21.0-0.30.3
Weight adjusted by age1.82.76.8-2.6-2.42.4-1.71.4-1.9-1.31.4-1.3-1.71.7-1.00.9-0.50.5
Bone surface0.20.50.9-0.7-0.30.10.1-0.3-0.40.20.8-0.8-1.01.0-0.80.8-0.80.9
Bone volume0.10.10.5-0.7-0.30.4-0.40.20.1-0.40.0-0.0-0.50.5-0.10.1-0.10.1
Breakpoint value in progressive ratio session0.40.40.9-0.6-0.90.9-0.80.7-0.2-0.7-0.60.70.2-0.20.6-0.60.7-0.7
Number of licking bursts0.00.10.3-0.4-0.50.5-0.20.3-0.5-0.10.1-0.1-0.30.3-0.20.1-0.10.1
Context. condit. distance diff. score1.92.35.30.3-0.71.0-2.12.1-0.4-2.3-1.21.31.4-1.41.5-1.61.8-1.8
Locomotion velocity, session 12.72.96.71.62.1-2.32.5-2.60.62.50.8-1.0-0.30.3-1.31.4-1.71.7
Locomotion distance, session 11.52.04.02.01.7-1.60.9-0.81.80.6-1.51.41.7-1.71.2-1.20.9-1.0
Locomotion velocity, session 22.63.07.82.22.7-2.82.6-2.52.22.4-0.40.20.3-0.3-0.10.2-0.70.7
Locomotion distance, session 20.81.13.10.70.7-0.5-0.00.11.8-0.2-1.41.51.0-1.01.3-1.21.1-1.1
Locomotion velocity, session 31.01.12.71.21.5-1.61.5-1.60.61.60.1-0.30.3-0.3-0.60.7-0.90.9
Locomotion distance, session 31.81.95.32.32.2-2.21.4-1.41.61.1-1.10.91.3-1.30.5-0.50.1-0.2
Stereotopy head waving bouts, day 30.40.41.80.40.5-0.61.2-1.2-0.01.30.3-0.4-0.20.2-0.40.5-0.60.6
Stereotopy head waving duration, day 30.20.20.90.50.5-0.50.8-0.80.10.9-0.1-0.0-0.00.0-0.00.0-0.10.1
Locomotion velocity, session 70.50.51.91.41.1-1.00.4-0.30.60.2-0.60.50.9-0.90.5-0.50.3-0.3
Locomotion distance, session 73.84.97.82.72.0-1.60.10.22.4-0.5-2.82.72.8-2.82.5-2.52.2-2.2
Stereotopy head waving bouts, day 70.20.31.5-0.5-0.90.8-0.40.4-1.2-0.30.4-0.4-0.20.2-0.20.20.0-0.0
Stereotopy head waving duration, day 70.60.82.7-0.9-1.00.9-0.20.1-1.70.21.0-1.0-1.01.0-0.80.8-0.60.6
Locomotion velocity, session 80.81.02.21.50.4-0.3-0.40.6-0.2-0.7-1.01.01.4-1.41.2-1.21.2-1.2
Locomotion distance, session 83.55.18.30.6-0.40.8-2.32.41.0-2.7-2.52.62.4-2.42.7-2.82.9-2.9
Degree of sensitization distance1.41.52.6-0.6-0.91.1-1.51.60.3-1.6-1.11.10.7-0.71.4-1.41.6-1.5
Degree of sensitization stereotypy0.40.41.0-0.5-1.01.0-0.80.9-1.0-0.8-0.00.10.1-0.10.2-0.30.5-0.5
Conditioned locomotion2.22.66.2-1.8-2.42.5-2.52.5-1.2-2.40.10.1-0.50.50.7-0.81.2-1.2
Cocaine response after cond. corrected0.10.10.50.50.4-0.40.1-0.10.20.1-0.30.30.7-0.70.1-0.10.0-0.0
Cocaine response after cond. not corrected0.40.41.11.01.0-1.00.6-0.60.40.6-0.40.30.9-0.9-0.10.1-0.30.2
Cocaine response before conditioning0.30.41.21.11.1-1.10.8-0.70.40.6-0.20.20.5-0.5-0.10.1-0.30.3
Saline control response1.21.63.7-1.9-1.81.8-1.71.5-1.5-1.60.9-0.8-0.90.9-0.70.6-0.30.3
Bone: connectivity density0.10.20.50.50.5-0.3-0.10.10.7-0.2-0.50.60.2-0.20.6-0.60.5-0.5
Bone: cortical apparent density1.62.25.22.12.1-2.01.4-1.32.31.1-1.41.31.3-1.30.9-0.90.5-0.5
Bone: cortical area3.85.911.3-3.3-3.32.9-2.01.4-3.4-1.22.9-2.7-2.52.5-2.01.9-1.41.4
Bone: cortical porosity1.51.62.9-1.3-0.60.40.5-0.7-1.00.91.4-1.5-1.41.4-1.71.7-1.71.7
Bone: cortical porosity1.51.62.6-1.5-1.00.8-0.0-0.2-1.50.31.5-1.5-1.41.4-1.61.6-1.51.5
Bone: cortical thickness3.45.611.3-3.4-3.12.8-1.61.0-2.9-0.72.9-2.7-2.82.8-2.01.9-1.41.4
Bone: cortical thickness0.91.12.1-1.2-1.41.3-1.00.8-1.4-0.71.4-1.2-1.01.0-0.70.6-0.30.3
Bone: cortical tissue density1.72.45.82.12.2-2.21.6-1.42.41.3-1.51.41.3-1.30.9-0.80.5-0.5
Condit. Reinf. active minus inactive responses1.11.23.2-1.6-1.81.8-1.71.5-1.0-1.50.5-0.3-0.50.50.0-0.10.4-0.4
Condit. Reinf. active-inactive response ratio0.70.71.7-0.8-1.21.3-1.31.3-0.6-1.2-0.00.2-0.00.00.5-0.50.8-0.7
Condit. Reinf. active responses1.82.35.9-2.4-2.42.4-2.12.0-1.4-1.90.8-0.6-0.90.9-0.20.20.2-0.2
Condit. Reinf. inactive responses0.40.51.6-1.3-1.11.1-0.90.9-0.4-0.80.4-0.3-0.50.5-0.20.2-0.00.1
Incentive salience index mean0.91.12.9-1.6-1.71.7-1.51.3-1.1-1.30.7-0.6-0.60.6-0.20.20.1-0.1
Condit. Reinf. lever presses0.10.20.3-0.3-0.40.5-0.50.60.1-0.5-0.20.20.1-0.10.4-0.50.5-0.5
Condit. Reinf. active minus inactive responses0.40.51.8-0.5-1.01.0-0.90.8-1.3-0.70.7-0.6-0.30.3-0.20.10.1-0.1
Condit. Reinf. active-inactive response ratio1.41.63.1-1.8-1.71.6-0.60.4-1.6-0.21.6-1.5-1.51.5-1.11.0-0.70.7
Condit. Reinf. active responses0.50.71.40.3-0.40.5-1.11.1-0.1-1.1-0.50.60.7-0.71.0-1.01.2-1.2
Condit. Reinf. inactive responses1.62.03.21.51.0-0.7-0.50.61.3-0.8-1.81.81.7-1.71.7-1.71.6-1.6
Condit. Reinf. lever presses1.82.54.50.1-0.71.0-1.61.90.6-1.9-1.61.71.4-1.41.9-2.02.1-2.1
Condit. Reinf. lever reinforcers received1.31.83.30.5-0.40.6-1.51.60.1-1.7-1.11.31.3-1.31.6-1.71.8-1.8
Conditioned reinforcement - actives0.10.20.6-0.30.10.1-0.40.40.8-0.4-0.40.40.1-0.10.5-0.50.4-0.4
Conditioned reinforcement - inactives0.40.61.4-1.2-1.21.2-1.01.0-0.9-0.80.5-0.4-0.60.6-0.20.20.0-0.0
Conditioned locomotion0.30.41.0-1.0-0.81.0-0.80.80.2-0.60.2-0.1-0.60.60.5-0.50.6-0.6
Patch foraging indifference point 0 sec0.50.91.4-0.9-0.90.9-0.91.00.8-0.9-1.11.20.3-0.31.1-1.11.2-1.1
Patch foraging indifference point AUC0.10.10.2-0.1-0.40.3-0.30.4-0.2-0.4-0.20.20.3-0.30.4-0.40.5-0.5
Delay disc. indifference point, 0s delay0.20.21.70.0-0.30.3-0.60.4-1.3-0.60.3-0.3-0.30.3-0.50.4-0.30.3
Delay disc. indifference point, 16s delay1.41.64.31.80.6-0.90.00.10.6-0.4-1.51.52.1-2.11.3-1.31.2-1.2
Delay disc. indifference point, 2s delay0.30.30.80.60.2-0.40.7-0.7-0.90.70.4-0.4-0.10.1-0.70.6-0.60.6
Delay disc. indifference point, 24s delay2.22.46.52.22.3-2.52.3-2.11.42.0-0.30.11.0-1.0-0.30.3-0.70.7
Delay disc. indifference point, 4s delay0.20.21.30.9-0.1-0.40.5-0.6-1.10.50.2-0.20.3-0.3-0.40.3-0.30.2
Delay disc. indifference point, 8s delay1.11.31.91.41.2-1.31.2-1.3-1.01.01.0-1.0-0.10.1-1.31.2-1.41.3
Indifference point function ln k0.71.22.61.21.3-1.10.3-0.21.60.1-1.61.61.2-1.21.1-1.00.8-0.8
Indifference point function log k0.71.22.61.21.3-1.10.3-0.21.60.1-1.61.61.2-1.21.1-1.00.8-0.8
Patch foraging total patch changes 0 sec0.81.52.5-0.8-0.91.1-1.21.31.0-1.3-1.41.50.6-0.61.5-1.51.6-1.5
Patch foraging total patch changes 12 sec0.20.30.9-0.9-0.80.7-0.20.20.7-0.2-0.40.5-0.20.20.6-0.50.6-0.5
Patch foraging total patch changes 18 sec1.42.14.10.4-0.50.5-1.01.10.8-1.2-1.71.81.5-1.51.9-1.92.0-2.0
Patch foraging total patch changes 24 sec0.61.13.0-1.4-1.71.7-1.51.5-1.1-1.40.2-0.1-0.40.40.2-0.30.6-0.6
Patch foraging total patch changes 6 sec0.40.63.2-1.8-1.21.1-0.40.30.3-0.20.2-0.1-0.90.9-0.20.2-0.10.2
Patch foraging time to switch 0 sec0.40.82.21.21.2-1.41.5-1.40.61.40.4-0.50.0-0.0-0.50.5-0.70.7
Patch foraging water rate 0 sec1.93.99.1-2.1-2.72.9-3.03.0-1.3-2.9-0.81.00.3-0.31.2-1.31.8-1.7
Patch foraging water rate 12 sec1.53.25.4-0.0-0.61.1-2.12.20.9-2.2-1.71.91.4-1.42.2-2.22.3-2.3
Patch foraging water rate 18 sec1.62.54.6-1.2-1.61.9-2.12.20.1-2.1-1.41.50.4-0.41.6-1.71.9-1.9
Patch foraging water rate 24 sec5.67.815.1-1.4-2.52.9-3.73.90.0-3.8-2.22.51.6-1.62.9-3.03.4-3.4
Patch foraging water rate 6 sec0.60.91.8-0.1-0.50.8-1.21.3-0.0-1.2-1.01.10.5-0.51.1-1.21.3-1.3
Seeking ratio, delayed vs. immediate footshock0.70.91.6-1.3-1.01.0-0.80.6-1.2-0.60.8-0.8-1.01.0-1.11.0-0.80.8
Distance traveled before self-admin0.50.72.3-1.1-1.31.3-1.00.9-1.5-0.80.10.0-0.50.5-0.50.4-0.20.2
Distance traveled after self-admin1.41.83.5-0.8-1.31.4-1.91.8-0.0-1.9-1.21.30.7-0.71.3-1.31.5-1.5
Extensor digitorum longus weight0.93.66.00.4-0.40.7-1.92.21.2-2.4-1.92.11.8-1.82.3-2.32.4-2.4
Bone: elastic displacement0.70.83.0-1.7-1.51.5-0.90.8-0.6-0.50.3-0.2-0.90.9-0.10.10.2-0.1
Bone: elastic work4.05.214.2-3.8-3.22.9-1.31.0-2.4-0.52.4-2.2-2.82.8-1.81.8-1.31.4
Bone: endosteal estimation0.20.41.00.50.1-0.1-0.40.70.1-0.8-0.60.61.0-1.00.7-0.70.7-0.7
Bone: endosteal perimeter0.71.63.9-1.2-1.10.8-0.30.2-2.0-0.21.7-1.7-1.01.0-1.61.5-1.41.4
Epididymis fat weight0.93.18.4-1.6-2.32.5-2.92.8-1.5-2.90.00.20.1-0.10.8-0.91.3-1.3
Delta time in closed arm before/after self-admin0.10.10.30.0-0.20.10.1-0.1-0.20.10.6-0.5-0.50.5-0.00.00.0-0.0
Delta time in open arm before/after self-admin0.40.40.9-0.4-0.70.6-0.70.60.1-0.8-0.90.90.4-0.40.4-0.50.5-0.5
Diff in mean of infusions in LGA sessions0.20.20.6-0.7-0.80.6-0.10.1-0.5-0.00.5-0.5-0.40.4-0.40.4-0.30.3
Delay discount exponential model param1.01.14.3-2.1-1.21.7-1.41.30.2-1.10.2-0.1-1.01.00.3-0.30.5-0.4
Extinction: sum of active levers before priming0.40.51.20.70.5-0.60.5-0.41.10.4-0.90.90.6-0.60.7-0.70.6-0.6
Active lever presses in extinction session 60.10.10.6-0.1-0.30.00.6-0.7-0.10.8-0.30.3-0.20.2-0.10.1-0.10.1
Bone: final force3.14.910.8-3.2-3.33.1-2.52.1-2.9-1.92.2-2.0-2.02.0-1.41.2-0.70.7
Bone: final moment3.55.712.7-3.6-3.63.4-2.62.2-3.0-2.02.3-2.0-2.12.1-1.51.3-0.70.8
Food consumed during 24 hour testing period0.50.71.8-0.7-1.21.3-1.21.1-1.1-1.10.00.00.1-0.10.5-0.60.8-0.8
Glucose4.36.818.02.63.5-3.84.1-4.21.84.20.2-0.60.2-0.2-1.31.5-2.12.1
Heart weight0.40.61.5-1.2-0.91.0-0.90.7-0.9-0.70.9-0.8-0.20.2-0.70.7-0.50.5
Delay discount hyperbolic model param0.91.03.7-1.9-1.11.5-1.41.30.4-1.10.1-0.0-0.90.90.4-0.40.5-0.4
Intermittent access intake day 1-15 change0.00.10.3-0.2-0.20.2-0.10.0-0.4-0.10.6-0.6-0.30.3-0.30.3-0.30.3
Intermittent access intake escalation0.00.10.3-0.2-0.10.1-0.10.0-0.3-0.10.5-0.5-0.30.3-0.30.2-0.20.2
Intermittent access intake escalation 20.40.41.0-0.7-0.30.4-0.30.1-0.6-0.21.0-0.9-0.90.9-0.70.7-0.60.6
Intermitt. access day 1 inactive lever presses0.72.77.0-2.0-2.62.6-2.42.3-1.2-2.3-0.30.40.1-0.10.7-0.81.2-1.2
Intermitt. access day 15 inactive lever presses0.81.64.3-0.9-1.41.6-2.12.0-0.7-2.1-0.50.70.5-0.50.9-0.91.2-1.2
Intermitt. access escalation Index0.30.51.3-0.8-1.01.0-1.21.0-0.7-1.1-0.00.10.1-0.1-0.0-0.00.2-0.2
Intermittent access day 1 total infusions0.10.10.3-0.6-0.20.4-0.20.20.5-0.1-0.40.4-0.00.00.4-0.40.4-0.3
Intermittent access day 15 total infusions0.10.21.1-1.1-0.70.8-0.40.4-0.1-0.30.4-0.3-0.40.4-0.10.10.00.0
Intermittent access terminal intake (last 3 days)0.30.41.4-1.2-0.70.9-0.60.6-0.3-0.40.7-0.6-0.70.7-0.30.3-0.20.2
Intermittent access total infusions0.10.10.6-0.8-0.50.6-0.30.40.0-0.10.1-0.1-0.10.10.1-0.10.2-0.1
Intermittent access day 1 locomotion0.10.10.4-0.7-0.40.5-0.20.30.4-0.10.1-0.1-0.50.50.3-0.20.3-0.2
Intermittent access day 15 total locomotion0.30.51.3-1.1-0.91.0-0.60.6-0.5-0.30.8-0.7-1.01.0-0.20.2-0.00.0
Intermittent access total locomotion0.20.20.8-0.9-0.70.8-0.40.4-0.0-0.20.3-0.2-0.50.50.2-0.20.3-0.2
Intermittent access standard deviation0.20.50.80.70.4-0.50.8-0.7-0.80.90.9-0.9-0.40.4-0.60.6-0.60.6
Left kidney weight0.31.42.7-0.7-0.50.30.7-0.8-1.40.91.6-1.6-1.31.3-1.41.4-1.31.3
Right kidney weight0.21.01.9-0.5-0.40.30.7-0.8-1.20.91.3-1.4-1.21.2-1.21.1-1.01.0
Cocaine induced anxiety1.42.03.3-1.8-1.41.2-0.40.1-1.6-0.01.8-1.7-1.61.6-1.61.6-1.41.4
Post-drug Anxiety0.20.20.4-0.4-0.50.20.3-0.3-0.50.30.6-0.6-0.20.2-0.60.6-0.60.5
Baseline Anxiety1.31.52.81.71.4-1.61.3-1.11.71.0-1.21.11.3-1.31.0-0.90.6-0.6
Tail length2.38.822.3-4.7-4.54.2-2.52.0-3.7-1.72.9-2.7-3.23.2-2.01.8-1.11.1
Length with tail2.39.916.9-4.0-3.63.1-1.20.6-4.1-0.33.8-3.7-3.83.8-3.23.1-2.52.5
Length without tail1.13.56.3-1.4-1.20.90.2-0.4-2.40.52.5-2.5-2.42.4-2.32.3-2.02.0
Times rat made contact with spout0.70.83.4-1.8-1.21.3-0.40.2-0.6-0.00.8-0.7-1.31.3-0.60.6-0.40.4
Lifetime Intake0.00.00.1-0.2-0.10.2-0.00.10.30.1-0.10.10.1-0.10.3-0.30.3-0.3
Liver weight, left0.50.81.80.30.8-0.91.3-1.40.11.30.3-0.5-0.10.1-0.91.0-1.21.2
Liver weight, right2.23.88.8-3.0-2.92.7-1.61.3-2.6-1.11.9-1.7-2.12.1-1.41.3-0.80.9
Locomotor activity0.30.50.90.91.0-0.80.6-0.60.80.6-0.90.80.6-0.60.5-0.50.3-0.3
Locomotor testing distance0.61.02.31.21.0-0.80.3-0.20.90.2-1.51.51.3-1.31.1-1.10.9-0.9
Locomotor testing rearing0.81.53.00.4-0.30.4-0.80.90.7-0.8-1.61.71.2-1.21.7-1.71.7-1.7
Locomotion in novel chamber0.10.20.3-0.3-0.50.5-0.50.5-0.0-0.5-0.20.30.1-0.10.4-0.40.5-0.5
Locomotion in novel chamber post-restriction0.71.13.9-2.0-1.31.3-1.10.9-0.6-0.91.0-1.0-1.21.2-0.70.7-0.60.6
Fecal boli incidents, locomotor time 10.20.31.00.40.9-0.60.4-0.51.00.6-0.40.50.2-0.20.3-0.30.1-0.1
Change in fecal boli incidents, locomotor task1.51.54.31.51.7-1.92.1-1.81.31.8-0.40.3-0.10.1-0.10.2-0.50.5
Time >=10cm from walls, locomotor time 10.70.71.60.8-0.00.2-0.60.90.1-0.8-0.91.00.5-0.51.1-1.21.2-1.2
Bouts of movement, locomotor time 11.01.22.61.51.6-1.61.2-1.31.51.2-0.70.60.9-0.90.4-0.40.1-0.1
Total resting periods, locomotor time 11.31.53.51.51.9-1.91.6-1.71.81.6-0.70.50.7-0.70.3-0.2-0.10.1
Rest time, locomotor task time 10.81.02.40.11.0-1.01.4-1.50.91.60.4-0.6-0.60.6-0.80.9-1.11.1
Distance moved, locomotor task time 10.30.51.4-0.7-1.21.1-0.91.0-0.9-1.10.3-0.2-0.20.20.0-0.10.3-0.3
Vertical activity count, locomotor time 10.51.24.1-0.6-1.11.3-1.82.0-0.6-2.0-0.00.20.1-0.10.7-0.71.0-1.0
Time >=10cm from walls, locomotor time 20.20.31.2-0.5-0.30.20.7-0.70.01.10.5-0.5-0.90.9-0.20.2-0.20.3
Bouts of movement, locomotor time 20.60.92.41.61.4-1.41.0-0.90.90.9-0.70.61.3-1.30.4-0.40.2-0.2
Total resting periods, locomotor time 20.30.61.51.21.0-1.00.6-0.50.70.5-0.60.51.1-1.10.4-0.40.3-0.3
Rest time, locomotor task time 20.20.20.50.10.3-0.40.6-0.60.40.40.7-0.7-0.50.5-0.20.3-0.40.4
Distance moved, locomotor task time 20.20.20.7-0.6-0.80.6-0.2-0.0-0.9-0.00.4-0.4-0.40.4-0.50.5-0.40.4
Vertical activity count, locomotor time 20.20.20.5-0.0-0.50.5-0.60.7-0.5-0.6-0.40.40.4-0.40.3-0.40.5-0.5
Light reinforcement 10.92.36.0-1.5-1.72.1-2.42.2-0.0-2.2-0.50.70.1-0.11.2-1.31.6-1.5
Light reinforcement 21.21.84.0-1.9-1.82.0-1.91.6-1.4-1.61.3-1.1-1.21.2-0.40.30.00.0
Bone: marrow area0.20.51.10.60.1-0.1-0.50.70.1-0.9-0.70.71.0-1.00.7-0.70.7-0.7
Bone: maximum diameter1.83.49.0-1.8-1.91.5-0.60.3-3.0-0.22.6-2.5-1.81.8-2.12.0-1.61.6
Bone: maximum force2.74.810.8-3.3-3.33.1-2.52.1-2.7-2.02.0-1.8-1.91.9-1.31.2-0.70.7
Bone: maximum moment3.05.313.1-3.6-3.53.3-2.62.1-2.7-2.02.1-1.9-2.12.1-1.41.3-0.70.7
Mean time between licks in bursts0.30.71.91.41.3-1.41.1-1.10.61.0-0.60.50.8-0.80.1-0.1-0.10.1
Mean num. licks in bursts0.10.10.6-0.8-0.40.5-0.30.20.3-0.20.1-0.1-0.30.30.2-0.20.2-0.2
Cd content in liver2.42.74.71.00.3-0.0-0.81.01.5-1.1-2.02.11.9-1.92.2-2.22.1-2.1
Co content in liver0.00.00.2-0.5-0.20.2-0.10.10.1-0.10.00.0-0.30.3-0.10.2-0.10.2
Cu content in liver0.70.81.8-1.2-0.80.8-0.30.1-1.00.11.1-1.0-1.31.3-0.90.9-0.70.7
Fe content in liver0.50.61.10.60.2-0.1-0.20.20.4-0.3-1.11.01.0-1.01.1-1.11.0-1.0
K content in liver0.90.92.3-1.3-1.31.5-1.41.5-0.8-1.40.3-0.2-0.30.30.2-0.20.5-0.4
Mg content in liver0.90.92.0-0.3-0.40.8-1.31.40.5-1.4-0.70.80.5-0.51.1-1.11.2-1.2
Mn content in liver0.20.20.6-0.2-0.20.2-0.20.1-0.8-0.00.6-0.6-0.60.6-0.40.4-0.30.3
Na content in liver0.00.00.1-0.0-0.00.1-0.30.4-0.2-0.3-0.10.10.1-0.10.1-0.10.1-0.1
Rb content in liver1.82.15.0-1.0-1.71.9-2.22.2-0.6-2.2-0.50.60.2-0.21.2-1.21.6-1.5
Se content in liver0.50.61.3-0.2-0.50.7-1.11.1-0.2-1.1-0.40.40.3-0.30.8-0.91.0-1.0
Sr content in liver0.50.41.1-0.10.4-0.61.0-1.00.41.00.3-0.3-0.40.4-0.60.7-0.80.8
Zn content in liver0.80.82.5-1.6-1.21.2-0.80.7-0.8-0.60.9-0.8-1.11.1-0.60.6-0.40.5
Bone: minimum diameter2.03.79.0-3.0-3.02.7-1.71.4-2.7-1.21.8-1.7-1.81.8-1.31.2-0.70.7
Time in familiar zone, hab. session 10.20.20.50.10.1-0.10.1-0.10.70.1-0.60.60.3-0.30.6-0.60.5-0.5
Time in novel zone, hab. session 10.10.10.70.2-0.10.1-0.40.2-0.9-0.30.4-0.4-0.00.0-0.30.2-0.20.2
Total zone transitions, hab. session 10.70.91.60.70.4-0.3-0.10.31.2-0.4-1.21.21.2-1.21.3-1.31.2-1.2
Total locomotion distance, hab. session 11.11.52.5-0.1-0.80.9-1.51.40.3-1.5-1.21.31.1-1.11.4-1.41.6-1.6
Locomotion velocity, hab. session 11.01.42.2-0.3-0.81.0-1.41.40.4-1.5-1.11.21.0-1.01.3-1.31.5-1.4
Time in familiar zone, hab. session 20.70.71.30.80.5-0.3-0.30.40.8-0.5-1.11.11.1-1.11.0-1.00.9-0.9
Time in novel zone, hab. session 20.20.20.30.10.2-0.20.5-0.6-0.30.60.4-0.4-0.30.3-0.40.4-0.50.5
Total zone transitions, hab. session 21.92.44.30.50.20.1-0.91.01.8-1.2-1.92.01.6-1.62.1-2.12.0-2.0
Total locomotion distance, hab. session 21.72.23.9-0.5-0.81.1-1.91.81.0-2.0-1.41.51.1-1.11.7-1.71.9-1.8
Locomotion velocity, hab. session 21.52.04.2-0.8-1.11.3-2.01.90.7-2.1-1.11.30.8-0.81.5-1.51.7-1.6
Novel to familiar place preference ratio1.01.13.3-1.8-1.71.7-1.31.2-0.1-1.00.2-0.1-1.01.00.3-0.30.5-0.5
Novelty place preference0.90.93.1-1.8-1.61.6-1.11.0-0.2-0.90.3-0.1-1.11.10.2-0.20.4-0.4
Time in novel zone, NPP test0.80.92.5-1.6-1.51.5-1.21.1-0.0-1.00.00.1-0.80.80.4-0.40.7-0.6
Total zone transitions, NPP test1.52.23.60.90.3-0.1-0.80.91.4-1.1-1.81.91.8-1.81.9-1.91.8-1.8
Total locomotion distance, NPP test2.73.65.9-0.1-0.50.9-1.91.91.6-2.1-2.22.31.8-1.82.3-2.32.4-2.4
Locomotion velocity, NPP test2.02.94.5-0.3-0.71.0-1.91.81.3-2.0-1.92.01.5-1.52.0-2.02.1-2.1
Intraocular pressure0.60.81.6-0.6-1.11.0-1.21.30.4-1.3-0.50.60.2-0.21.0-1.01.1-1.1
Delta distance traveled before/after self-admin1.11.22.30.40.10.1-0.80.81.1-1.0-1.11.11.2-1.21.5-1.51.5-1.5
Delta ambulatory time before/after self-admin1.21.52.71.10.8-0.6-0.20.21.6-0.4-1.41.31.6-1.61.6-1.61.4-1.4
Parametrial fat weight0.30.72.1-1.4-1.31.4-1.21.1-0.3-1.10.1-0.1-0.30.30.3-0.40.5-0.5
Pavlov. Cond. lever latency4.15.210.12.31.2-0.7-1.01.31.4-1.7-2.82.83.2-3.22.6-2.62.5-2.6
Pavlov. Cond. magazine entry latency2.43.05.3-2.2-1.81.5-0.30.1-2.30.12.2-2.1-1.91.9-2.01.9-1.61.7
Pavlov. Cond. change in total contacts0.50.51.3-0.9-0.40.30.4-0.40.00.60.8-0.7-1.11.1-0.70.7-0.70.7
Pavlov. Cond. index score3.64.58.5-2.9-2.31.9-0.40.2-2.30.22.6-2.5-2.72.7-2.22.2-1.91.9
Pavlov. Cond. latency score4.05.18.8-2.8-2.01.60.1-0.4-2.20.72.8-2.8-3.03.0-2.62.5-2.32.3
Pavlov. Cond. lever contacts2.12.55.5-2.1-1.20.90.4-0.6-0.80.91.9-1.8-2.32.3-1.71.7-1.61.7
Pavlov. Cond. magazine entry number2.93.65.82.21.7-1.3-0.10.32.1-0.6-2.42.42.3-2.32.2-2.21.9-2.0
Pavlov. Cond. intertrial magazine entries0.81.02.30.0-0.10.4-1.21.30.7-1.5-1.01.10.8-0.81.1-1.11.2-1.2
Pavlov. Cond. lever-magazine prob. diff.3.13.87.9-2.8-2.32.0-0.50.3-2.20.02.3-2.2-2.52.5-1.91.9-1.51.6
Pavlov. Cond. response bias2.83.55.9-2.2-1.51.20.3-0.4-1.80.72.4-2.4-2.42.4-2.22.1-1.91.9
Pavlov. Cond. lever latency2.02.75.60.81.5-1.72.1-2.30.02.41.3-1.4-1.21.2-1.61.7-1.91.9
Pavlov. Cond. magazine entry latency3.03.66.11.70.9-0.7-0.10.51.7-0.7-2.52.52.3-2.32.4-2.42.3-2.3
Pavlov. Cond. change in total contacts2.03.35.10.90.10.1-1.11.51.3-1.6-2.22.22.3-2.32.2-2.22.3-2.3
Pavlov. Cond. index score2.33.15.30.6-0.20.5-1.21.51.0-1.6-2.12.22.1-2.12.2-2.22.3-2.3
Pavlov. Cond. latency score2.22.95.10.6-0.30.5-1.21.50.8-1.6-2.02.02.0-2.02.2-2.22.3-2.3
Pavlov. Cond. lever contacts2.12.95.4-0.5-1.21.5-2.02.30.4-2.3-1.51.71.4-1.41.8-1.92.1-2.1
Pavlov. Cond. magazine entry number2.63.25.4-1.5-0.60.40.4-0.8-1.40.92.3-2.3-2.22.2-2.32.3-2.32.3
Pavlov. Cond. intertrial magazine entries0.81.12.6-1.4-1.61.6-1.51.3-1.5-1.20.8-0.7-0.70.7-0.50.4-0.10.1
Pavlov. Cond. lever-magazine prob. diff.2.33.15.20.90.00.2-1.01.31.1-1.5-2.22.22.2-2.22.2-2.32.3-2.3
Pavlov. Cond. response bias2.33.15.20.3-0.40.7-1.51.81.1-1.9-2.12.21.9-1.92.2-2.22.3-2.3
Time in closed arm before self-admin0.50.61.60.50.8-1.11.2-1.20.51.20.4-0.6-0.10.1-0.50.6-0.80.8
Time in closed arm after self-admin1.21.33.80.90.9-1.41.9-1.80.81.91.0-1.1-0.70.7-0.40.5-0.70.7
Time in open arm before self-admin0.20.21.0-0.20.10.3-0.10.2-0.50.00.4-0.3-1.01.0-0.30.3-0.20.2
Time in open arm after self-admin0.50.51.8-0.2-0.30.5-0.80.80.2-0.9-1.31.30.5-0.50.6-0.60.6-0.6
Bone: periosteal estimation0.92.04.7-1.8-2.01.8-1.41.2-2.2-1.11.6-1.5-1.11.1-1.00.9-0.60.6
Bone: periosteal perimeter4.57.713.2-3.0-2.41.8-0.3-0.3-3.50.53.6-3.6-3.13.1-3.33.3-2.92.9
Bone: post-yield work0.10.10.50.00.1-0.0-0.20.20.7-0.3-0.20.20.4-0.40.3-0.30.3-0.3
Progressive ratio test 1 active lever presses0.10.20.4-0.4-0.30.5-0.50.60.2-0.4-0.20.20.2-0.20.5-0.50.5-0.5
Progressive ratio test 1 breakpoint0.10.10.3-0.5-0.30.5-0.50.60.2-0.4-0.00.10.0-0.00.4-0.40.5-0.4
Progressive ratio test 1 inactive lever presses2.02.87.3-2.0-2.62.7-2.52.6-1.4-2.30.20.0-0.20.20.6-0.71.2-1.2
Progressive ratio test 2 active lever presses0.20.20.4-0.4-0.40.5-0.50.50.4-0.5-0.40.40.2-0.20.6-0.60.6-0.6
Progressive ratio test 2 breakpoint0.20.20.4-0.4-0.40.5-0.50.50.4-0.5-0.40.40.2-0.20.6-0.60.6-0.6
Progressive ratio test 2 inactive lever presses0.20.30.9-1.0-0.91.0-0.60.5-0.7-0.50.3-0.3-0.20.2-0.10.10.1-0.1
Incentive Sensitization - Responses0.00.00.1-0.2-0.10.2-0.40.20.0-0.4-0.20.20.1-0.10.1-0.10.1-0.1
Incentive Sensitization - Breakpoint0.00.00.2-0.1-0.10.2-0.40.20.0-0.4-0.30.30.2-0.20.1-0.10.2-0.2
Sum of active levers in priming session hrs 5-60.50.50.80.0-0.20.4-0.70.60.3-0.7-0.70.80.9-0.90.8-0.90.9-0.9
Progressive ratio0.30.51.80.80.8-1.00.6-0.51.30.3-0.80.80.7-0.70.5-0.40.2-0.2
Food seeking constrained by brief footshock0.10.10.20.50.3-0.40.4-0.40.20.30.1-0.1-0.00.0-0.10.1-0.20.2
Seeking ratio, punishment vs. effort0.10.10.60.1-0.30.3-0.40.4-0.8-0.40.2-0.20.0-0.00.0-0.10.2-0.2
Retroperitoneal fat weight2.39.724.8-3.6-4.75.0-4.74.6-3.1-4.40.6-0.2-0.50.51.0-1.22.1-2.1
Reaction time number correct3.66.912.10.4-0.81.3-2.73.11.0-3.1-2.72.82.5-2.53.2-3.33.5-3.5
Reaction time mean minus median0.30.81.4-0.00.5-0.61.1-1.1-0.11.20.8-0.9-0.80.8-0.91.0-1.11.1
Reaction time mean minus median AUC0.41.01.9-0.7-0.40.20.5-0.6-0.90.71.3-1.4-1.21.2-1.11.1-1.11.1
Reaction time num false alarms0.20.20.60.40.5-0.60.6-0.60.70.4-0.50.50.5-0.50.3-0.20.1-0.1
Reaction time num false alarms AUC0.30.50.90.70.8-0.80.8-0.81.00.6-0.80.70.7-0.70.4-0.40.2-0.2
Reaction time trials correct on left3.66.912.10.4-0.81.3-2.73.11.0-3.1-2.72.82.5-2.53.2-3.33.5-3.5
Reaction time trials on left3.77.012.30.4-0.91.4-2.83.11.0-3.1-2.72.92.5-2.53.2-3.33.5-3.5
Reaction time mean0.10.20.7-0.2-0.50.5-0.70.8-0.4-0.8-0.20.30.2-0.20.4-0.40.5-0.5
Reaction time mean AUC0.20.40.9-0.2-0.50.6-0.90.9-0.3-1.0-0.50.50.4-0.40.6-0.60.7-0.7
Median of all reaction times0.40.61.5-0.1-0.60.7-1.11.2-0.5-1.2-0.50.60.5-0.50.7-0.80.9-0.9
Reaction time omissions0.20.31.7-0.5-0.70.7-0.40.6-1.3-0.40.6-0.5-0.50.5-0.50.4-0.20.2
Reaction time false alarm rate1.31.85.10.51.2-1.52.1-2.30.42.10.6-0.8-0.60.6-1.21.3-1.61.6
Reaction time premature initiation rate0.91.24.01.31.3-1.41.0-0.72.00.6-1.11.01.0-1.01.0-0.90.7-0.7
Reaction time premature initiations2.34.27.71.40.6-0.5-0.61.12.3-1.2-2.52.52.3-2.32.8-2.72.6-2.6
Std. dev. reaction times0.10.20.60.80.6-0.70.6-0.40.40.4-0.40.40.5-0.50.3-0.30.2-0.2
Reaction time trials completed3.77.012.30.4-0.91.4-2.83.11.0-3.1-2.72.92.5-2.53.2-3.33.5-3.5
Reaction time trials AUC3.87.312.90.3-0.91.4-2.83.21.1-3.2-2.82.92.5-2.53.3-3.43.6-3.6
Run reversals in cocaine runway, females1.81.83.71.60.7-0.70.20.01.0-0.2-1.81.71.9-1.91.5-1.51.4-1.4
Run reversals in cocaine runway, males0.90.92.7-1.4-0.40.6-0.20.1-0.4-0.10.8-0.8-1.61.6-1.01.0-1.01.0
Latency to leave start box in cocaine runway0.60.71.70.91.3-0.90.2-0.31.30.0-1.00.91.0-1.00.6-0.60.4-0.3
Latency to leave start box in cocaine runway, F1.01.22.50.50.4-0.1-0.60.50.9-0.8-1.51.51.6-1.61.2-1.21.1-1.1
Latency to leave start box in cocaine runway, M0.40.41.60.71.2-1.10.7-0.71.00.70.1-0.2-0.20.2-0.20.3-0.50.5
Std. dev. time between licks in bursts1.72.34.3-0.2-0.91.1-2.11.9-0.2-2.0-1.51.61.3-1.31.6-1.71.9-1.8
Total sessions with >9 infusions0.20.30.80.90.9-0.70.5-0.30.50.4-0.40.30.4-0.40.5-0.40.3-0.3
Short access day 1 total inactive lever presses0.20.21.0-0.4-0.50.5-0.30.2-1.0-0.10.5-0.5-0.20.2-0.50.4-0.30.3
Short access day 10 total inactive lever presses1.22.98.6-2.3-2.92.7-2.42.2-2.2-2.10.6-0.4-0.80.8-0.20.10.4-0.4
Short access day 1 total infusions0.91.22.81.71.3-1.31.1-0.71.10.9-1.00.91.2-1.21.0-0.90.7-0.7
Short access day 10 total infusions0.40.52.1-1.4-0.91.1-0.70.8-0.5-0.40.4-0.4-0.70.7-0.20.2-0.10.1
Short access total infusions0.20.20.50.30.2-0.0-0.10.20.5-0.0-0.50.50.6-0.60.7-0.70.7-0.7
Short access day 1 locomotion0.30.30.90.70.9-0.90.8-0.60.50.80.4-0.4-0.40.4-0.20.2-0.40.4
Short access day 10 total locomotion0.40.81.5-0.10.6-0.60.9-0.90.21.00.8-0.9-1.21.2-0.90.9-1.11.1
Short access total locomotion0.60.71.30.10.7-0.60.8-0.70.00.91.1-1.1-1.11.1-0.80.8-0.90.9
One hour access (0.3 mA shock)0.50.61.2-0.1-0.30.4-0.70.70.5-0.7-0.70.70.8-0.81.1-1.11.1-1.1
Compulsive drug intake0.60.72.0-0.4-0.90.9-1.41.2-0.8-1.4-0.60.70.6-0.60.4-0.50.6-0.6
One hour access (shock baseline)0.00.10.3-0.5-0.00.10.1-0.10.40.30.4-0.4-0.30.3-0.00.1-0.10.1
Social response proportion0.40.40.70.70.0-0.1-0.40.50.0-0.6-0.70.80.9-0.90.7-0.80.8-0.8
Social responses0.20.20.40.1-0.50.4-0.60.6-0.3-0.6-0.20.30.2-0.20.5-0.50.6-0.7
Social time0.30.40.60.50.1-0.0-0.50.60.2-0.6-0.60.60.8-0.80.7-0.70.8-0.8
Soleus weight0.92.68.1-2.9-2.32.1-1.31.0-1.4-0.91.6-1.5-1.81.8-1.21.2-0.90.9
Bone: stiffness0.30.51.4-0.6-0.80.7-0.70.6-1.2-0.61.0-0.9-0.50.5-0.80.7-0.60.6
Tibialis anterior weight0.00.10.80.20.3-0.3-0.20.30.9-0.5-0.40.40.3-0.30.4-0.30.3-0.3
Time to tail flick, vehicle, before self-admin0.40.40.80.00.5-0.50.7-0.90.20.70.8-0.9-0.50.5-0.50.6-0.70.7
Time to tail flick, vehicle, after self-admin0.91.23.11.01.3-1.41.7-1.60.31.80.7-0.9-0.40.4-0.70.7-0.90.9
Time to tail flick, test, before self-admin0.40.40.90.50.7-0.80.9-1.00.70.80.1-0.2-0.40.4-0.30.4-0.50.5
Time to tail flick, test, after self-admin0.70.81.80.90.5-0.81.3-1.3-0.71.30.7-0.7-0.70.7-0.70.7-0.80.7
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.2-0.60.6-0.50.6-0.4-0.4-0.30.40.1-0.10.3-0.40.5-0.5
Delta time to tail flick, test, before/after SA0.30.30.80.90.5-0.60.8-0.8-0.70.90.5-0.6-0.10.1-0.40.3-0.40.3
Tibia length7.620.856.2-5.1-5.34.6-2.21.7-7.5-1.15.7-5.5-4.74.7-4.74.4-3.53.4
Ambulatory time before self-admin1.21.74.9-1.7-2.22.1-1.71.6-2.2-1.40.3-0.1-0.70.7-0.50.40.0-0.0
Ambulatory time after self-admin1.41.72.9-0.7-1.31.4-1.71.7-0.4-1.7-1.21.30.8-0.81.2-1.31.5-1.5
Bone: tissue strength1.41.44.0-1.9-1.92.0-1.71.6-0.4-1.5-0.10.3-0.50.50.4-0.40.7-0.7
Total heroin consumption0.10.10.9-0.0-0.20.4-0.40.2-0.9-0.2-0.00.10.1-0.1-0.30.2-0.10.1
Bone: trabecular number0.10.20.30.10.5-0.50.4-0.50.50.30.1-0.1-0.50.5-0.40.4-0.50.5
Bone: trabecular spacing3.03.96.80.4-1.11.5-2.42.5-0.7-2.5-1.61.82.0-2.02.2-2.32.6-2.6
Bone: trabecular thickness1.21.53.1-1.4-0.20.00.6-0.80.30.81.2-1.2-1.81.8-1.41.5-1.61.6
Bone: trabecular tissue density0.40.51.31.11.0-1.11.1-1.0-0.01.10.3-0.30.3-0.3-0.30.4-0.50.5
Water consumed over 24 hours0.30.51.0-0.60.1-0.10.7-0.90.21.00.5-0.5-0.90.9-0.70.7-0.80.8
Number of responses in last shaping day0.40.41.2-0.30.20.1-0.10.2-0.5-0.01.0-1.0-1.11.1-0.70.7-0.60.6