Hub : Genes

Enc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Enc1 0.03 0.02 6.7e-04 0.02 0.01 0 0.02 6.5e-03 9.6e-03 1.0e-01 4.2e-03
2 Brain gene expression Enc1 0.19 0.07 0.0e+00 0.33 0.33 0.34 0.34 2.2e-31 1.0e-31 9.8e-33 8.3e-33
3 NAcc gene expression Enc1 0.21 0.13 0.0e+00 0.19 0.17 0.19 0.19 1.7e-28 2.5e-24 1.0e-27 2.4e-27
4 Liver isoform ratio NM_001003401.2 0.03 0.02 2.8e-03 0 0.01 0.01 0 1.2e-01 1.2e-02 2.7e-02 1.2e-01
5 Liver isoform ratio XM_063281492.1 0.03 0.02 2.6e-03 0 0.01 0.01 0 1.5e-01 1.0e-02 1.4e-02 8.8e-02
6 PL mRNA stability Enc1 0.04 0.03 1.2e-05 0.04 0.04 0.03 0.04 5.8e-05 1.1e-05 5.0e-04 9.4e-05
7 NAcc mRNA stability Enc1 0.02 0.02 8.1e-03 -0 0 0.01 -0 9.9e-01 1.2e-01 1.9e-02 8.7e-01
8 Brain mRNA stability Enc1 0.08 0.05 5.0e-09 0.1 0.1 0.1 0.1 1.3e-09 5.6e-10 1.7e-09 9.8e-10
9 Adipose alternative TSS NM_001003401.2 0.04 0.03 7.6e-03 -0 0 -0 0 4.0e-01 7.7e-02 6.4e-01 2.9e-01
10 Adipose alternative TSS XM_063281492.1 0.04 0.03 5.5e-03 -0 0.01 -0 0 3.9e-01 5.7e-02 5.0e-01 1.5e-01
11 Adipose isoform ratio XM_063281492.1 0.04 0.03 5.6e-03 -0 0.01 -0 0 4.8e-01 5.8e-02 6.0e-01 3.6e-01
12 Adipose isoform ratio NM_001003401.2 0.04 0.03 5.1e-03 -0 0.01 -0 0 4.5e-01 7.0e-02 6.5e-01 3.0e-01
13 Liver gene expression Enc1 0.07 0.05 7.5e-04 0.03 0.03 0.03 0.03 2.1e-04 2.4e-04 1.2e-04 2.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.2-0.3-0.10.2-0.30.2-0.20.30.0-0.50.50.5-0.50.4
Area under the delay curve0.30.41.01.00.8-0.50.9-0.90.7-1.00.70.2-0.2-0.20.20.2
BMI with tail1.14.05.82.32.2-2.42.2-2.12.0-1.31.22.1-2.1-2.22.1-1.2
BMI without tail0.73.85.52.32.2-2.32.0-2.02.4-1.91.71.8-1.8-1.91.8-1.2
Body weight1.46.110.03.13.0-3.03.0-3.03.1-3.23.01.1-1.2-1.31.20.3
Weight adjusted by age0.92.57.7-0.20.0-0.1-0.30.5-0.62.0-1.72.1-2.1-2.02.1-2.8
Bone surface0.10.10.30.20.4-0.50.3-0.30.1-0.00.2-0.50.50.5-0.50.4
Bone volume0.10.30.6-0.4-0.30.3-0.40.4-0.40.5-0.2-0.80.80.8-0.80.4
Breakpoint value in progressive ratio session0.00.00.3-0.0-0.10.20.0-0.0-0.1-0.00.1-0.20.20.3-0.20.6
Number of licking bursts0.10.20.6-0.0-0.20.4-0.40.30.7-0.80.60.2-0.2-0.30.3-0.5
Context. condit. distance diff. score0.91.12.3-1.5-1.31.1-1.51.5-1.01.3-1.30.1-0.1-0.10.1-0.7
Locomotion velocity, session 10.30.30.6-0.6-0.70.7-0.80.70.2-0.60.4-0.60.60.5-0.5-0.1
Locomotion distance, session 10.81.01.9-1.4-1.31.4-1.31.2-0.5-0.0-0.3-1.01.00.9-0.90.1
Locomotion velocity, session 20.40.51.70.1-0.10.2-0.10.00.9-1.31.1-0.80.80.6-0.70.4
Locomotion distance, session 20.81.23.0-1.3-1.61.7-1.61.5-0.5-0.1-0.1-1.00.90.8-0.8-0.2
Locomotion velocity, session 30.80.92.0-1.3-1.21.2-1.41.4-0.40.4-1.0-0.30.20.1-0.2-1.2
Locomotion distance, session 30.80.91.8-1.2-1.31.1-1.31.3-0.80.6-1.2-0.50.40.4-0.5-0.7
Stereotopy head waving bouts, day 31.21.42.4-1.6-1.21.4-1.31.2-0.90.3-0.4-1.41.41.4-1.40.9
Stereotopy head waving duration, day 30.40.52.1-0.10.3-0.20.3-0.40.0-0.50.6-0.90.90.9-0.91.5
Locomotion velocity, session 70.91.02.2-0.6-0.50.6-0.91.0-0.61.4-1.30.9-0.9-0.90.9-1.5
Locomotion distance, session 70.10.10.30.20.1-0.10.0-0.00.5-0.40.30.3-0.3-0.40.3-0.6
Stereotopy head waving bouts, day 71.72.04.2-2.0-1.61.5-2.02.0-1.31.5-1.7-0.30.30.3-0.3-1.3
Stereotopy head waving duration, day 70.40.51.0-1.0-0.60.6-1.01.0-0.71.0-1.00.2-0.2-0.20.2-0.8
Locomotion velocity, session 81.41.64.1-1.9-1.71.8-2.02.0-0.91.0-0.9-0.50.50.4-0.4-0.4
Locomotion distance, session 80.91.33.0-1.4-1.51.4-1.71.7-0.60.9-1.10.1-0.2-0.20.2-1.5
Degree of sensitization distance0.60.61.71.00.9-0.60.8-0.91.0-0.91.30.5-0.5-0.50.50.3
Degree of sensitization stereotypy1.61.83.7-1.6-1.31.1-1.71.8-1.21.8-1.90.3-0.3-0.40.4-1.9
Conditioned locomotion0.20.20.9-0.4-0.20.1-0.20.3-0.90.8-0.9-0.30.30.4-0.40.0
Cocaine response after cond. corrected0.30.40.90.80.9-1.00.6-0.61.0-0.70.80.3-0.3-0.40.3-0.4
Cocaine response after cond. not corrected0.71.01.91.21.1-1.20.9-0.91.4-1.01.20.7-0.8-0.80.8-0.6
Cocaine response before conditioning0.20.20.60.1-0.10.1-0.20.20.10.2-0.10.7-0.7-0.70.7-0.7
Saline control response0.60.81.51.21.1-1.00.8-0.70.40.3-0.11.2-1.2-1.21.2-0.6
Bone: connectivity density0.10.10.3-0.10.1-0.10.1-0.1-0.1-0.00.1-0.50.50.6-0.60.5
Bone: cortical apparent density1.93.16.6-2.2-2.11.8-2.12.2-2.12.3-2.6-0.00.10.1-0.1-1.3
Bone: cortical area0.81.36.4-0.6-0.30.4-0.20.4-2.22.5-2.10.2-0.10.20.00.8
Bone: cortical porosity0.00.00.1-0.3-0.30.3-0.30.2-0.0-0.0-0.0-0.20.20.1-0.10.0
Bone: cortical porosity0.20.20.5-0.6-0.60.7-0.60.6-0.50.5-0.5-0.10.10.1-0.10.0
Bone: cortical thickness1.83.011.8-1.3-1.21.2-1.21.4-2.93.4-3.10.5-0.4-0.10.3-0.2
Bone: cortical thickness0.50.61.20.80.8-0.80.7-0.6-0.10.7-0.61.1-1.1-1.01.0-0.5
Bone: cortical tissue density1.82.85.8-2.2-2.11.8-2.12.2-2.02.1-2.4-0.10.20.2-0.2-1.2
Condit. Reinf. active minus inactive responses0.70.83.60.1-0.0-0.3-0.40.5-0.00.8-0.81.1-1.1-1.11.1-1.9
Condit. Reinf. active-inactive response ratio1.11.23.30.40.3-0.60.00.1-0.31.2-1.11.6-1.5-1.51.5-1.8
Condit. Reinf. active responses0.40.63.30.20.0-0.4-0.30.40.50.2-0.30.8-0.9-0.90.9-1.8
Condit. Reinf. inactive responses0.10.20.80.30.2-0.30.1-0.20.9-0.80.7-0.20.10.0-0.1-0.2
Incentive salience index mean0.30.41.90.40.4-0.70.1-0.10.8-0.30.20.6-0.6-0.70.6-1.4
Condit. Reinf. lever presses0.20.20.7-0.2-0.1-0.2-0.20.10.8-0.80.7-0.60.60.4-0.5-0.2
Condit. Reinf. active minus inactive responses0.71.12.80.2-0.10.1-0.20.30.00.8-0.71.7-1.7-1.61.7-1.6
Condit. Reinf. active-inactive response ratio0.30.51.50.50.2-0.10.2-0.20.5-0.10.21.2-1.2-1.21.2-0.7
Condit. Reinf. active responses0.91.33.6-0.2-0.40.4-0.60.7-0.31.2-1.11.5-1.5-1.51.5-1.9
Condit. Reinf. inactive responses0.30.41.40.30.4-0.50.3-0.20.30.2-0.20.8-0.9-0.80.8-1.2
Condit. Reinf. lever presses0.30.41.2-0.1-0.20.2-0.30.40.00.6-0.40.9-0.9-0.91.0-1.1
Condit. Reinf. lever reinforcers received0.81.23.3-0.1-0.30.3-0.50.5-0.21.1-1.01.5-1.5-1.51.5-1.8
Conditioned reinforcement - actives0.20.61.70.81.1-0.91.3-1.20.4-0.10.30.8-0.8-0.70.70.3
Conditioned reinforcement - inactives0.10.31.6-0.7-0.20.4-0.30.3-0.71.3-0.70.1-0.10.00.0-0.0
Conditioned locomotion0.60.93.0-1.3-0.70.9-0.40.5-1.51.7-1.5-0.40.40.6-0.50.2
Patch foraging indifference point 0 sec0.61.84.21.81.4-2.11.4-1.41.9-1.61.70.4-0.5-0.60.5-0.5
Patch foraging indifference point AUC0.30.72.00.60.6-0.30.9-1.00.8-1.41.2-0.30.30.3-0.31.1
Delay disc. indifference point, 0s delay0.30.41.1-0.3-0.30.4-0.50.5-0.20.7-0.60.7-0.7-0.70.7-1.0
Delay disc. indifference point, 16s delay0.10.20.70.50.5-0.10.6-0.5-0.1-0.3-0.1-0.10.20.2-0.20.9
Delay disc. indifference point, 2s delay0.10.10.40.10.10.10.1-0.00.20.1-0.10.6-0.6-0.60.6-0.6
Delay disc. indifference point, 24s delay1.32.15.01.81.6-1.41.6-1.62.1-2.21.90.5-0.6-0.70.6-0.2
Delay disc. indifference point, 4s delay0.30.31.30.1-0.1-0.1-0.0-0.00.6-1.20.8-0.60.60.5-0.50.4
Delay disc. indifference point, 8s delay0.81.42.81.71.4-1.21.5-1.51.4-1.51.30.6-0.6-0.70.6-0.0
Indifference point function ln k0.00.10.40.10.1-0.0-0.10.1-0.20.6-0.60.3-0.3-0.30.3-0.6
Indifference point function log k0.00.10.40.10.1-0.0-0.10.1-0.20.6-0.60.3-0.3-0.30.3-0.6
Patch foraging total patch changes 0 sec0.61.73.91.71.4-2.01.4-1.41.8-1.71.70.2-0.3-0.40.3-0.4
Patch foraging total patch changes 12 sec1.01.42.41.51.3-1.51.2-1.31.5-1.41.50.7-0.8-0.80.8-0.3
Patch foraging total patch changes 18 sec0.40.81.11.10.9-0.80.9-0.90.9-0.80.71.1-1.1-1.11.1-0.5
Patch foraging total patch changes 24 sec0.62.03.51.91.5-1.71.6-1.61.5-1.21.31.2-1.2-1.31.3-0.3
Patch foraging total patch changes 6 sec1.42.45.52.01.5-2.11.6-1.72.2-2.22.30.1-0.1-0.30.20.2
Patch foraging time to switch 0 sec0.20.71.60.30.2-0.3-0.10.2-0.00.8-0.51.3-1.2-1.31.3-1.1
Patch foraging water rate 0 sec0.20.71.9-0.2-0.0-0.00.2-0.20.2-0.80.5-1.41.31.3-1.40.7
Patch foraging water rate 12 sec0.41.63.8-1.3-1.21.1-1.41.5-1.32.0-2.00.4-0.4-0.40.4-1.5
Patch foraging water rate 18 sec0.30.81.90.70.5-0.40.3-0.20.20.3-0.21.4-1.4-1.41.4-1.1
Patch foraging water rate 24 sec0.30.41.00.81.0-0.80.9-0.80.8-0.70.50.1-0.1-0.10.1-0.1
Patch foraging water rate 6 sec1.42.02.9-1.7-1.41.7-1.11.1-1.50.8-1.1-1.61.61.7-1.71.0
Seeking ratio, delayed vs. immediate footshock0.10.20.5-0.3-0.40.0-0.20.20.4-0.70.3-0.70.60.6-0.6-0.2
Distance traveled before self-admin0.10.10.40.50.2-0.30.2-0.20.4-0.60.50.3-0.3-0.30.3-0.1
Distance traveled after self-admin1.01.83.91.71.3-1.61.3-1.32.0-1.81.80.6-0.6-0.80.7-0.4
Extensor digitorum longus weight0.10.20.70.10.2-0.40.2-0.30.2-0.30.6-0.60.60.6-0.60.8
Bone: elastic displacement0.91.23.2-1.3-1.31.8-1.11.0-1.20.5-0.4-0.90.90.9-0.91.1
Bone: elastic work0.81.02.5-0.9-0.60.9-0.60.5-0.90.40.0-1.31.31.4-1.31.6
Bone: endosteal estimation0.30.71.41.11.1-1.11.0-1.11.0-0.91.20.0-0.0-0.10.10.4
Bone: endosteal perimeter0.10.20.60.60.7-0.80.6-0.60.20.10.10.2-0.2-0.20.20.1
Epididymis fat weight0.94.87.32.72.3-2.42.2-2.12.4-1.91.82.2-2.2-2.32.2-1.4
Delta time in closed arm before/after self-admin1.11.02.1-1.0-1.01.3-1.01.1-1.40.9-1.2-0.70.80.8-0.80.6
Delta time in open arm before/after self-admin2.22.66.80.70.7-0.90.4-0.20.41.1-0.62.4-2.4-2.42.4-2.6
Diff in mean of infusions in LGA sessions0.61.02.6-0.7-0.70.7-0.40.4-1.10.5-0.4-1.31.31.4-1.41.6
Delay discount exponential model param0.40.51.3-1.0-0.80.6-0.90.9-0.81.2-0.8-0.20.20.2-0.2-0.3
Extinction: sum of active levers before priming0.40.62.6-0.0-0.10.1-0.20.20.20.5-0.51.1-1.1-1.21.2-1.6
Active lever presses in extinction session 60.40.41.1-0.4-0.20.4-0.10.1-0.4-0.2-0.3-1.01.01.0-1.10.8
Bone: final force0.10.21.10.40.3-0.30.1-0.1-0.61.1-0.50.5-0.5-0.40.50.3
Bone: final moment0.10.20.80.40.3-0.40.2-0.2-0.60.9-0.30.4-0.4-0.30.40.4
Food consumed during 24 hour testing period1.53.17.11.41.0-1.20.5-0.40.80.5-0.32.6-2.6-2.72.7-2.6
Glucose1.01.63.0-1.4-1.51.6-1.51.6-1.51.7-1.70.2-0.2-0.10.2-0.8
Heart weight1.52.43.91.71.5-1.51.5-1.41.3-0.70.72.0-2.0-2.01.9-1.3
Delay discount hyperbolic model param0.30.41.2-0.9-0.70.5-0.80.8-0.81.1-0.7-0.10.10.1-0.1-0.2
Intermittent access intake day 1-15 change0.10.41.2-0.8-0.80.7-0.60.6-0.91.1-0.80.1-0.1-0.10.1-0.2
Intermittent access intake escalation0.10.61.6-1.1-0.90.8-0.80.8-1.01.3-0.9-0.00.10.1-0.1-0.2
Intermittent access intake escalation 20.20.30.9-0.6-0.50.4-0.30.3-0.91.0-0.7-0.00.10.2-0.10.4
Intermitt. access day 1 inactive lever presses0.33.87.1-2.5-2.12.0-2.12.1-2.72.6-2.4-1.11.21.3-1.20.1
Intermitt. access day 15 inactive lever presses0.42.45.2-2.0-2.01.9-2.32.3-1.61.4-1.4-0.70.70.6-0.6-0.6
Intermitt. access escalation Index0.10.40.9-0.8-0.80.8-1.00.9-0.20.0-0.1-0.50.50.4-0.40.0
Intermittent access day 1 total infusions0.61.93.31.81.6-1.51.5-1.51.4-1.41.11.3-1.3-1.31.3-0.5
Intermittent access day 15 total infusions0.30.71.70.30.3-0.40.3-0.2-0.10.6-0.41.3-1.3-1.21.2-1.2
Intermittent access terminal intake (last 3 days)0.30.51.20.30.1-0.20.2-0.1-0.20.5-0.41.1-1.1-1.01.1-0.9
Intermittent access total infusions0.70.81.70.90.7-0.70.7-0.70.4-0.10.01.3-1.3-1.31.3-1.0
Intermittent access day 1 locomotion0.20.40.80.80.9-0.80.9-0.80.3-0.10.30.6-0.5-0.50.5-0.1
Intermittent access day 15 total locomotion0.41.72.91.11.5-1.41.6-1.50.40.60.21.7-1.6-1.51.6-0.6
Intermittent access total locomotion0.20.20.5-0.00.4-0.30.4-0.4-0.30.7-0.40.6-0.5-0.40.5-0.3
Intermittent access standard deviation0.10.51.3-0.6-0.80.5-0.60.7-0.71.0-1.00.5-0.5-0.50.5-1.2
Left kidney weight2.016.328.45.35.1-4.84.8-4.84.7-4.33.92.8-2.8-2.92.8-0.7
Right kidney weight2.517.329.65.45.2-4.95.1-5.04.6-4.13.83.1-3.2-3.23.1-0.9
Cocaine induced anxiety0.00.10.3-0.30.20.20.1-0.1-0.30.2-0.5-0.20.20.3-0.30.3
Post-drug Anxiety0.20.20.60.50.8-0.40.7-0.70.2-0.40.00.3-0.3-0.20.20.1
Baseline Anxiety0.10.20.70.60.1-0.30.2-0.20.6-0.90.70.2-0.2-0.30.3-0.3
Tail length0.52.97.12.02.0-1.81.8-1.92.4-2.72.5-0.1-0.0-0.10.00.5
Length with tail1.14.810.72.62.5-2.42.5-2.62.7-3.33.2-0.30.20.1-0.21.5
Length without tail0.42.34.41.91.8-1.81.9-1.91.9-2.12.10.0-0.1-0.10.01.0
Times rat made contact with spout3.23.78.11.71.4-1.41.2-1.01.4-0.30.12.8-2.8-2.82.8-2.3
Lifetime Intake0.40.50.90.80.6-0.60.7-0.60.6-0.50.30.9-0.9-0.90.9-0.7
Liver weight, left3.86.610.03.22.8-2.72.5-2.52.7-1.61.72.8-2.9-2.92.9-1.6
Liver weight, right1.01.83.41.81.7-1.91.6-1.61.7-1.71.40.4-0.4-0.50.4-0.5
Locomotor activity0.61.03.90.20.30.10.00.10.30.3-0.41.5-1.5-1.51.5-2.0
Locomotor testing distance1.74.39.51.61.6-1.31.3-1.11.00.3-0.43.1-3.1-3.03.0-2.7
Locomotor testing rearing0.93.37.21.41.3-1.11.1-0.90.50.8-0.92.7-2.7-2.62.6-2.4
Locomotion in novel chamber0.40.51.0-0.9-0.80.9-0.80.8-0.71.0-1.00.0-0.0-0.00.0-0.7
Locomotion in novel chamber post-restriction0.61.84.0-0.0-0.10.1-0.20.00.9-2.01.6-2.01.91.7-1.81.5
Fecal boli incidents, locomotor time 10.10.31.2-0.2-0.20.3-0.0-0.0-0.2-0.40.4-0.60.60.6-0.61.1
Change in fecal boli incidents, locomotor task0.10.10.3-0.5-0.40.1-0.50.5-0.0-0.0-0.1-0.30.30.2-0.3-0.3
Time >=10cm from walls, locomotor time 12.42.96.3-1.4-1.31.1-1.00.9-1.40.3-0.3-2.42.52.5-2.52.1
Bouts of movement, locomotor time 10.60.81.71.00.9-0.80.8-0.70.50.20.01.3-1.3-1.21.3-0.5
Total resting periods, locomotor time 10.70.81.21.11.0-0.80.9-0.90.7-0.10.41.1-1.1-1.11.1-0.2
Rest time, locomotor task time 10.10.20.6-0.2-0.70.3-0.80.7-0.0-0.0-0.00.1-0.1-0.20.2-0.8
Distance moved, locomotor task time 10.10.40.90.81.0-0.80.8-0.70.3-0.0-0.20.5-0.5-0.50.5-0.4
Vertical activity count, locomotor time 10.00.20.70.50.8-0.50.7-0.6-0.40.3-0.80.2-0.2-0.00.00.3
Time >=10cm from walls, locomotor time 20.10.20.6-0.2-0.10.0-0.20.10.2-0.60.4-0.80.80.7-0.80.4
Bouts of movement, locomotor time 20.00.10.3-0.4-0.20.2-0.30.3-0.1-0.30.1-0.60.60.5-0.50.3
Total resting periods, locomotor time 20.00.10.3-0.5-0.40.3-0.50.5-0.1-0.10.0-0.40.40.3-0.40.0
Rest time, locomotor task time 20.81.43.0-0.4-0.80.6-1.01.1-0.81.5-1.21.4-1.3-1.31.4-1.7
Distance moved, locomotor task time 20.40.51.00.81.0-0.90.9-0.80.7-0.4-0.10.6-0.7-0.60.6-0.8
Vertical activity count, locomotor time 20.10.30.50.70.7-0.60.4-0.30.2-0.2-0.50.5-0.5-0.50.5-0.7
Light reinforcement 10.41.62.91.51.5-1.71.7-1.71.5-1.51.20.8-0.8-0.80.7-0.1
Light reinforcement 20.10.20.90.10.1-0.10.3-0.30.1-1.00.5-0.50.50.5-0.50.6
Bone: marrow area0.30.71.51.11.1-1.11.0-1.11.0-1.01.20.0-0.0-0.10.00.4
Bone: maximum diameter0.30.61.41.01.2-1.21.2-1.1-0.20.5-0.10.4-0.3-0.20.30.9
Bone: maximum force0.20.40.90.70.6-0.70.4-0.3-0.30.9-0.30.9-0.9-0.80.90.0
Bone: maximum moment0.20.40.60.80.6-0.80.5-0.4-0.20.7-0.10.8-0.7-0.70.80.1
Mean time between licks in bursts0.21.12.11.51.1-1.01.3-1.40.8-0.91.30.6-0.5-0.50.51.2
Mean num. licks in bursts0.51.43.01.01.0-1.31.1-0.9-0.00.9-0.81.7-1.7-1.51.6-1.1
Cd content in liver0.60.71.50.10.0-0.2-0.10.2-0.51.1-1.11.2-1.2-1.11.2-1.0
Co content in liver0.81.02.20.91.0-1.00.5-0.40.50.5-0.21.3-1.3-1.31.3-1.5
Cu content in liver0.10.10.2-0.4-0.20.5-0.40.4-0.30.4-0.4-0.10.10.1-0.1-0.2
Fe content in liver0.70.91.2-1.1-1.00.9-1.11.1-1.01.0-0.7-1.01.01.0-1.00.5
K content in liver0.50.51.30.91.1-1.00.9-0.90.9-0.60.60.4-0.4-0.40.4-0.3
Mg content in liver0.50.51.6-0.8-0.60.8-0.80.8-1.01.3-1.10.1-0.1-0.10.1-0.3
Mn content in liver1.92.13.4-1.7-1.81.7-1.71.8-1.81.8-1.8-0.80.80.9-0.80.1
Na content in liver0.50.51.20.71.1-1.01.0-1.00.8-0.70.70.1-0.1-0.10.10.4
Rb content in liver0.40.41.00.20.3-0.10.2-0.1-0.30.8-0.71.0-1.0-0.90.9-0.8
Se content in liver1.41.62.7-1.7-1.51.3-1.61.7-1.41.4-1.5-0.80.80.8-0.8-0.7
Sr content in liver0.20.20.40.00.1-0.60.2-0.20.10.00.2-0.60.60.6-0.60.4
Zn content in liver0.10.10.4-0.4-0.10.3-0.30.4-0.40.5-0.60.1-0.1-0.10.1-0.4
Bone: minimum diameter1.22.37.1-1.6-1.51.4-1.41.5-2.52.7-2.3-0.20.30.5-0.40.2
Time in familiar zone, hab. session 10.00.00.1-0.3-0.20.3-0.20.20.2-0.20.20.0-0.0-0.10.1-0.1
Time in novel zone, hab. session 11.82.04.02.01.8-2.01.5-1.51.3-0.40.91.4-1.4-1.41.4-0.4
Total zone transitions, hab. session 10.71.01.7-1.2-1.31.2-1.31.2-0.4-0.1-0.2-1.21.21.1-1.2-0.0
Total locomotion distance, hab. session 10.91.22.2-1.1-1.41.0-1.11.0-0.4-0.10.1-1.51.51.4-1.41.1
Locomotion velocity, hab. session 11.62.34.0-1.6-1.71.5-1.41.3-1.00.1-0.4-2.02.02.0-2.01.4
Time in familiar zone, hab. session 21.01.11.91.41.3-1.11.3-1.30.9-0.60.61.1-1.1-1.01.0-0.0
Time in novel zone, hab. session 20.00.10.4-0.1-0.10.0-0.30.30.10.00.00.1-0.1-0.20.1-0.6
Total zone transitions, hab. session 20.30.42.00.1-0.10.1-0.20.11.1-1.41.2-0.40.30.2-0.3-0.3
Total locomotion distance, hab. session 20.10.20.6-0.5-0.80.7-0.60.6-0.1-0.3-0.0-0.20.20.1-0.1-0.1
Locomotion velocity, hab. session 20.20.20.6-0.5-0.80.7-0.60.60.1-0.50.2-0.40.30.2-0.3-0.0
Novel to familiar place preference ratio0.30.31.1-0.5-0.50.4-0.50.6-0.81.1-1.0-0.00.00.1-0.0-0.6
Novelty place preference0.30.31.3-0.4-0.30.2-0.40.5-0.81.2-1.10.2-0.1-0.10.1-0.8
Time in novel zone, NPP test0.30.41.6-0.4-0.40.2-0.50.6-0.91.3-1.20.1-0.1-0.10.1-0.8
Total zone transitions, NPP test0.71.01.7-0.9-1.11.1-1.21.10.2-0.80.6-1.31.21.0-1.10.2
Total locomotion distance, NPP test1.31.83.9-1.6-2.01.9-1.91.8-1.00.3-0.5-1.21.21.1-1.20.4
Locomotion velocity, NPP test1.21.73.7-1.5-1.91.8-1.81.7-0.90.1-0.4-1.31.21.2-1.20.4
Intraocular pressure3.25.29.3-3.0-2.92.7-2.82.8-2.31.8-2.3-1.91.81.8-1.8-0.5
Delta distance traveled before/after self-admin1.11.22.21.41.3-1.51.3-1.31.5-1.21.30.4-0.4-0.50.4-0.1
Delta ambulatory time before/after self-admin0.91.62.81.51.4-1.51.3-1.31.7-1.11.21.0-1.1-1.11.1-0.8
Parametrial fat weight0.10.10.20.30.4-0.30.3-0.30.40.10.10.4-0.5-0.50.4-0.4
Pavlov. Cond. lever latency0.20.30.70.1-0.00.1-0.10.2-0.50.8-0.70.7-0.7-0.60.7-0.6
Pavlov. Cond. magazine entry latency2.22.85.62.01.9-2.11.9-2.02.3-2.32.40.0-0.1-0.20.10.7
Pavlov. Cond. change in total contacts0.30.40.80.70.7-0.90.9-0.90.7-0.50.6-0.10.10.1-0.10.4
Pavlov. Cond. index score1.01.32.61.21.2-1.41.3-1.41.5-1.61.6-0.30.20.2-0.20.7
Pavlov. Cond. latency score0.81.02.20.91.0-1.11.1-1.21.3-1.51.4-0.30.30.2-0.30.9
Pavlov. Cond. lever contacts0.30.30.9-0.4-0.30.2-0.10.10.0-0.40.2-1.00.90.9-0.90.6
Pavlov. Cond. magazine entry number3.74.78.4-2.8-2.62.9-2.72.7-2.82.5-2.5-0.80.80.9-0.8-0.2
Pavlov. Cond. intertrial magazine entries0.50.61.2-1.1-1.00.9-1.01.0-0.90.6-0.8-0.60.60.6-0.6-0.3
Pavlov. Cond. lever-magazine prob. diff.0.81.02.41.01.0-1.21.1-1.11.4-1.51.5-0.50.40.3-0.40.7
Pavlov. Cond. response bias1.62.03.91.61.7-1.91.7-1.72.0-1.91.8-0.0-0.1-0.10.00.3
Pavlov. Cond. lever latency0.20.31.2-0.10.00.20.2-0.2-0.1-0.50.4-0.70.70.7-0.71.1
Pavlov. Cond. magazine entry latency2.94.16.32.52.4-2.32.0-1.91.8-0.71.02.3-2.3-2.32.3-1.1
Pavlov. Cond. change in total contacts0.10.20.60.20.3-0.30.1-0.10.10.4-0.10.8-0.8-0.70.8-0.4
Pavlov. Cond. index score1.11.73.11.41.3-1.41.0-0.90.9-0.00.21.8-1.8-1.71.8-1.3
Pavlov. Cond. latency score1.32.13.71.61.5-1.61.2-1.11.1-0.20.31.9-1.9-1.91.9-1.4
Pavlov. Cond. lever contacts0.30.51.70.0-0.1-0.1-0.30.3-0.00.7-0.60.9-0.9-0.90.9-1.3
Pavlov. Cond. magazine entry number2.43.15.0-2.1-2.11.9-1.81.7-1.20.3-0.5-2.22.22.2-2.20.9
Pavlov. Cond. intertrial magazine entries0.41.01.6-1.0-1.11.2-0.60.5-0.8-0.1-0.2-1.21.21.2-1.21.0
Pavlov. Cond. lever-magazine prob. diff.1.42.24.21.51.4-1.41.1-1.01.00.00.22.1-2.1-2.02.1-1.4
Pavlov. Cond. response bias0.50.61.40.50.5-0.60.3-0.20.20.6-0.41.2-1.2-1.21.2-1.0
Time in closed arm before self-admin0.61.01.7-1.1-1.10.8-0.90.8-0.70.3-0.2-1.31.31.3-1.30.8
Time in closed arm after self-admin1.31.42.2-1.1-1.31.5-1.21.1-1.20.2-0.5-1.41.41.4-1.41.2
Time in open arm before self-admin1.82.13.41.91.8-1.51.7-1.81.8-1.71.80.9-0.9-1.00.90.1
Time in open arm after self-admin3.74.16.41.91.9-2.11.6-1.52.1-0.71.12.4-2.4-2.52.5-2.4
Bone: periosteal estimation0.10.31.30.10.3-0.30.3-0.3-0.91.1-0.70.10.00.2-0.10.7
Bone: periosteal perimeter0.20.41.30.20.4-0.30.5-0.4-1.01.1-0.70.1-0.00.2-0.01.1
Bone: post-yield work0.20.40.70.70.5-0.70.7-0.80.7-0.80.8-0.20.20.2-0.20.6
Progressive ratio test 1 active lever presses0.10.10.30.50.2-0.20.4-0.40.3-0.60.20.4-0.4-0.40.4-0.2
Progressive ratio test 1 breakpoint0.10.10.20.40.1-0.00.3-0.30.1-0.40.10.4-0.4-0.40.4-0.2
Progressive ratio test 1 inactive lever presses0.10.20.4-0.3-0.30.4-0.30.2-0.1-0.40.1-0.60.60.6-0.60.2
Progressive ratio test 2 active lever presses1.21.72.91.51.4-1.31.4-1.40.8-0.20.41.7-1.7-1.61.6-0.9
Progressive ratio test 2 breakpoint1.21.62.81.31.2-1.21.3-1.20.7-0.20.41.7-1.7-1.61.6-1.0
Progressive ratio test 2 inactive lever presses0.20.50.80.80.8-0.80.9-0.80.30.00.10.9-0.9-0.80.8-0.4
Incentive Sensitization - Responses1.23.34.42.12.0-2.12.0-1.91.6-0.71.12.1-2.1-2.12.1-1.1
Incentive Sensitization - Breakpoint1.43.24.42.01.9-2.01.9-1.81.6-0.71.12.1-2.1-2.12.1-1.2
Sum of active levers in priming session hrs 5-60.10.10.30.30.1-0.30.2-0.20.4-0.40.6-0.20.20.2-0.20.3
Progressive ratio0.30.92.00.70.6-0.80.4-0.40.60.3-0.11.3-1.3-1.41.3-1.4
Food seeking constrained by brief footshock1.41.73.31.81.4-1.31.2-1.31.8-1.81.80.7-0.8-0.90.80.2
Seeking ratio, punishment vs. effort0.30.71.90.30.3-0.00.3-0.40.6-1.41.2-0.90.90.8-0.91.3
Retroperitoneal fat weight0.52.44.41.61.3-1.31.1-1.01.5-0.80.82.0-2.0-2.12.1-1.7
Reaction time number correct0.31.22.3-1.3-1.21.2-1.31.4-1.31.1-1.5-0.50.50.6-0.6-0.6
Reaction time mean minus median0.00.10.3-0.4-0.50.6-0.60.50.1-0.20.30.1-0.1-0.20.2-0.3
Reaction time mean minus median AUC0.00.20.40.20.1-0.0-0.10.00.5-0.40.60.6-0.6-0.60.7-0.5
Reaction time num false alarms0.20.30.80.90.6-0.60.8-0.70.4-0.30.30.4-0.4-0.40.40.5
Reaction time num false alarms AUC0.20.51.11.00.7-0.70.9-0.90.6-0.60.50.5-0.5-0.40.40.6
Reaction time trials correct on left0.31.22.3-1.3-1.21.2-1.31.4-1.31.1-1.5-0.50.50.6-0.6-0.6
Reaction time trials on left0.41.42.7-1.4-1.41.3-1.41.5-1.51.3-1.7-0.50.50.5-0.5-0.7
Reaction time mean0.81.73.6-1.0-1.31.3-1.51.5-1.21.9-1.61.0-0.9-0.91.0-1.3
Reaction time mean AUC0.51.22.5-0.9-1.21.2-1.31.3-1.01.6-1.20.8-0.7-0.70.8-1.0
Median of all reaction times1.01.64.2-0.8-1.11.1-1.21.3-1.22.1-1.71.1-1.1-1.01.1-1.1
Reaction time omissions1.72.85.1-1.2-1.61.5-1.91.9-1.52.2-2.11.3-1.3-1.31.4-2.3
Reaction time false alarm rate1.01.42.51.61.3-1.31.5-1.61.3-1.21.30.6-0.6-0.60.60.9
Reaction time premature initiation rate2.74.27.52.62.3-2.32.4-2.42.6-2.52.71.1-1.2-1.31.20.3
Reaction time premature initiations0.41.22.01.41.2-1.21.2-1.21.4-1.41.40.7-0.8-0.80.8-0.2
Std. dev. reaction times0.20.81.8-1.0-1.21.2-1.31.3-0.50.8-0.50.4-0.4-0.50.5-0.9
Reaction time trials completed0.41.42.7-1.4-1.41.3-1.41.5-1.51.3-1.7-0.50.50.5-0.5-0.7
Reaction time trials AUC0.41.33.2-1.3-1.31.2-1.41.4-1.51.4-1.8-0.30.30.4-0.4-0.8
Run reversals in cocaine runway, females0.40.51.2-0.9-0.71.1-0.50.5-0.40.10.1-0.80.80.8-0.80.9
Run reversals in cocaine runway, males0.70.81.6-1.0-0.90.8-0.80.7-0.5-0.20.1-1.31.31.2-1.20.7
Latency to leave start box in cocaine runway1.21.63.9-1.2-0.80.9-0.60.5-0.6-0.40.3-2.02.02.0-2.01.3
Latency to leave start box in cocaine runway, F0.81.02.6-0.6-0.30.4-0.10.0-0.4-0.20.1-1.61.61.6-1.61.5
Latency to leave start box in cocaine runway, M0.40.40.7-0.8-0.70.8-0.60.5-0.3-0.10.3-0.80.80.7-0.70.3
Std. dev. time between licks in bursts0.81.53.11.61.5-1.31.4-1.51.5-1.61.80.2-0.2-0.30.20.8
Total sessions with >9 infusions0.10.20.70.60.2-0.30.2-0.20.6-0.80.40.3-0.3-0.40.3-0.5
Short access day 1 total inactive lever presses0.00.00.20.10.1-0.00.2-0.20.1-0.20.10.3-0.3-0.20.2-0.5
Short access day 10 total inactive lever presses0.11.01.7-1.3-1.00.9-0.80.8-0.90.9-0.6-1.21.21.2-1.20.4
Short access day 1 total infusions0.10.21.00.1-0.10.0-0.10.00.3-1.00.5-0.40.40.3-0.40.2
Short access day 10 total infusions0.10.20.5-0.0-0.20.4-0.20.3-0.60.5-0.70.6-0.5-0.50.5-0.4
Short access total infusions0.10.21.00.60.2-0.10.2-0.20.5-1.00.50.2-0.2-0.20.2-0.2
Short access day 1 locomotion0.00.10.2-0.2-0.20.2-0.20.2-0.30.2-0.40.1-0.1-0.10.1-0.4
Short access day 10 total locomotion1.56.110.6-3.2-3.02.8-2.93.0-3.02.9-2.8-1.41.51.5-1.5-0.5
Short access total locomotion1.01.52.6-1.5-1.51.4-1.41.4-1.61.4-1.5-0.70.70.7-0.7-0.3
One hour access (0.3 mA shock)0.20.20.40.50.5-0.50.6-0.50.10.1-0.00.6-0.6-0.50.5-0.5
Compulsive drug intake0.30.42.00.30.2-0.20.1-0.10.9-1.41.2-0.50.50.4-0.40.3
One hour access (shock baseline)0.20.41.00.20.3-0.30.4-0.3-0.61.0-0.80.9-0.8-0.70.8-0.6
Social response proportion5.36.712.3-3.5-3.43.4-3.23.1-2.82.0-2.0-2.02.12.1-2.00.8
Social responses1.62.14.2-2.0-1.92.0-1.91.9-1.61.3-1.5-0.70.70.7-0.7-0.3
Social time0.40.61.2-1.0-0.90.9-1.11.0-0.60.6-0.5-0.70.60.6-0.6-0.2
Soleus weight0.72.04.80.40.8-0.70.8-0.90.6-1.41.7-1.81.81.8-1.82.2
Bone: stiffness0.40.81.81.21.1-1.30.7-0.60.30.6-0.01.1-1.0-1.01.0-0.6
Tibialis anterior weight2.37.813.5-3.7-3.53.3-3.43.3-2.61.6-1.6-2.72.82.7-2.70.7
Time to tail flick, vehicle, before self-admin0.10.10.4-0.10.2-0.10.2-0.2-0.10.1-0.0-0.40.40.4-0.40.6
Time to tail flick, vehicle, after self-admin0.10.20.40.10.5-0.40.7-0.6-0.40.6-0.50.5-0.4-0.30.30.3
Time to tail flick, test, before self-admin0.60.71.7-0.7-0.80.7-0.70.8-0.91.3-1.20.7-0.7-0.60.7-1.0
Time to tail flick, test, after self-admin1.01.02.1-1.5-1.21.0-1.31.3-1.01.3-1.1-0.50.50.5-0.5-0.7
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.10.10.10.1-0.1-0.40.7-0.60.7-0.6-0.60.6-0.4
Delta time to tail flick, test, before/after SA0.70.92.3-0.7-0.40.4-0.50.4-0.2-0.30.2-1.51.51.4-1.51.0
Tibia length0.20.71.51.11.2-1.11.2-1.20.2-0.00.30.7-0.7-0.60.60.5
Ambulatory time before self-admin0.10.20.50.60.3-0.50.3-0.30.5-0.70.60.2-0.2-0.30.30.1
Ambulatory time after self-admin0.61.01.91.21.0-1.30.9-0.91.4-1.01.00.7-0.8-0.80.8-0.6
Bone: tissue strength0.10.10.30.30.1-0.40.2-0.2-0.20.5-0.10.5-0.4-0.40.40.3
Total heroin consumption0.30.31.0-0.5-0.50.3-0.30.3-0.91.0-0.6-0.40.40.5-0.50.7
Bone: trabecular number0.00.00.10.10.2-0.20.2-0.20.2-0.00.2-0.20.20.2-0.20.1
Bone: trabecular spacing0.60.81.9-0.7-0.91.0-0.91.0-1.01.3-1.40.7-0.6-0.60.6-0.8
Bone: trabecular thickness2.02.74.3-2.1-1.61.7-1.51.5-1.51.0-0.7-2.02.02.0-2.01.2
Bone: trabecular tissue density0.20.31.2-0.5-0.70.6-1.01.00.00.1-0.20.1-0.1-0.20.2-1.1
Water consumed over 24 hours2.44.69.22.01.7-1.81.1-1.01.7-0.30.32.9-3.0-3.03.0-2.9
Number of responses in last shaping day0.00.10.50.0-0.10.0-0.10.10.2-0.3-0.2-0.10.0-0.0-0.0-0.7