Hub : Genes

Enc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Enc1 0.03 0.02 6.7e-04 0.02 0.01 0 0.02 6.5e-03 9.6e-03 1.0e-01 4.5e-03
2 Brain gene expression Enc1 0.19 0.07 0.0e+00 0.33 0.33 0.34 0.34 2.2e-31 1.0e-31 9.7e-33 8.4e-33
3 NAcc gene expression Enc1 0.21 0.13 0.0e+00 0.19 0.17 0.19 0.19 1.7e-28 2.5e-24 1.0e-27 2.4e-27
4 Liver isoform ratio NM_001003401.2 0.03 0.02 2.8e-03 0 0.01 0.01 0 1.2e-01 1.2e-02 2.7e-02 1.2e-01
5 Liver isoform ratio XM_063281492.1 0.03 0.02 2.6e-03 0 0.01 0.01 0 1.5e-01 1.0e-02 1.4e-02 9.2e-02
6 PL mRNA stability Enc1 0.04 0.03 1.2e-05 0.04 0.04 0.03 0.04 5.8e-05 1.1e-05 5.6e-04 9.3e-05
7 Brain mRNA stability Enc1 0.08 0.05 5.0e-09 0.1 0.1 0.1 0.1 1.3e-09 5.6e-10 1.9e-09 9.8e-10
8 Adipose alternative TSS NM_001003401.2 0.04 0.03 7.6e-03 -0 0 -0 0 4.0e-01 7.7e-02 6.4e-01 3.0e-01
9 Adipose alternative TSS XM_063281492.1 0.04 0.03 5.5e-03 -0 0.01 -0 0 3.9e-01 5.7e-02 5.0e-01 1.6e-01
10 Adipose isoform ratio XM_063281492.1 0.04 0.03 5.6e-03 -0 0.01 -0 -0 4.8e-01 5.8e-02 6.0e-01 3.7e-01
11 Adipose isoform ratio NM_001003401.2 0.04 0.03 5.1e-03 -0 0.01 -0 0 4.5e-01 7.0e-02 6.5e-01 3.3e-01
12 Liver gene expression Enc1 0.07 0.05 7.5e-04 0.03 0.03 0.03 0.03 2.1e-04 2.4e-04 1.2e-04 2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.2-0.3-0.1-0.2-0.30.2-0.20.0-0.50.50.5-0.5-0.4
Area under the delay curve0.30.40.91.00.80.50.9-0.90.70.70.2-0.2-0.20.2-0.2
BMI with tail1.24.25.82.32.22.42.2-2.12.01.22.1-2.1-2.22.11.2
BMI without tail1.33.85.52.32.22.32.0-2.02.41.71.8-1.8-1.91.81.2
Body weight1.35.89.83.13.03.03.0-3.03.13.01.1-1.2-1.31.2-0.3
Weight adjusted by age1.62.47.7-0.20.00.1-0.30.5-0.6-1.72.1-2.1-2.02.12.8
Bone surface0.10.20.30.20.40.50.3-0.30.10.2-0.50.50.5-0.5-0.4
Bone volume0.20.30.6-0.4-0.3-0.3-0.40.4-0.4-0.2-0.80.80.8-0.8-0.4
Breakpoint value in progressive ratio session0.00.10.3-0.0-0.1-0.20.0-0.0-0.10.1-0.20.20.3-0.2-0.6
Number of licking bursts0.10.20.5-0.0-0.2-0.4-0.40.30.70.60.2-0.2-0.30.30.5
Context. condit. distance diff. score0.91.02.3-1.5-1.3-1.1-1.51.5-1.0-1.30.1-0.1-0.10.10.7
Locomotion velocity, session 10.30.30.6-0.6-0.7-0.7-0.80.70.20.4-0.60.60.5-0.50.1
Locomotion distance, session 10.81.11.9-1.4-1.3-1.4-1.31.2-0.5-0.3-1.01.00.9-0.9-0.1
Locomotion velocity, session 20.30.41.30.1-0.1-0.2-0.10.00.91.1-0.80.80.6-0.7-0.4
Locomotion distance, session 20.91.33.0-1.3-1.6-1.7-1.61.5-0.5-0.1-1.00.90.8-0.80.2
Locomotion velocity, session 30.80.92.0-1.3-1.2-1.2-1.41.4-0.4-1.0-0.30.20.1-0.21.2
Locomotion distance, session 30.90.91.8-1.2-1.3-1.1-1.31.3-0.8-1.2-0.50.40.4-0.50.7
Stereotopy head waving bouts, day 31.31.52.4-1.6-1.2-1.4-1.31.2-0.9-0.4-1.41.41.4-1.4-0.9
Stereotopy head waving duration, day 30.40.52.1-0.10.30.20.3-0.40.00.6-0.90.90.9-0.9-1.5
Locomotion velocity, session 70.80.92.2-0.6-0.5-0.6-0.91.0-0.6-1.30.9-0.9-0.90.91.5
Locomotion distance, session 70.10.10.30.20.10.10.0-0.00.50.30.3-0.3-0.40.30.6
Stereotopy head waving bouts, day 71.72.04.2-2.0-1.6-1.5-2.02.0-1.3-1.7-0.30.30.3-0.31.3
Stereotopy head waving duration, day 70.40.51.0-1.0-0.6-0.6-1.01.0-0.7-1.00.2-0.2-0.20.20.8
Locomotion velocity, session 81.41.74.1-1.9-1.7-1.8-2.02.0-0.9-0.9-0.50.50.4-0.40.4
Locomotion distance, session 80.91.43.0-1.4-1.5-1.4-1.71.7-0.6-1.10.1-0.2-0.20.21.5
Degree of sensitization distance0.60.61.71.00.90.60.8-0.91.01.30.5-0.5-0.50.5-0.3
Degree of sensitization stereotypy1.61.73.7-1.6-1.3-1.1-1.71.8-1.2-1.90.3-0.3-0.40.41.9
Conditioned locomotion0.20.20.9-0.4-0.2-0.1-0.20.3-0.9-0.9-0.30.30.4-0.4-0.0
Cocaine response after cond. corrected0.40.40.90.80.91.00.6-0.61.00.80.3-0.3-0.40.30.4
Cocaine response after cond. not corrected0.81.01.91.21.11.20.9-0.91.41.20.7-0.8-0.80.80.6
Cocaine response before conditioning0.20.20.60.1-0.1-0.1-0.20.20.1-0.10.7-0.7-0.70.70.7
Saline control response0.70.91.51.21.11.00.8-0.70.4-0.11.2-1.2-1.21.20.6
Bone: connectivity density0.10.10.3-0.10.10.10.1-0.1-0.10.1-0.50.50.6-0.6-0.5
Bone: cortical apparent density2.12.96.6-2.2-2.1-1.8-2.12.2-2.1-2.6-0.00.10.1-0.11.3
Bone: cortical area0.60.94.8-0.6-0.3-0.4-0.20.4-2.2-2.10.2-0.10.20.0-0.8
Bone: cortical porosity0.00.00.1-0.3-0.3-0.3-0.30.2-0.0-0.0-0.20.20.1-0.1-0.0
Bone: cortical porosity0.20.20.5-0.6-0.6-0.7-0.60.6-0.5-0.5-0.10.10.1-0.1-0.0
Bone: cortical thickness1.32.29.7-1.3-1.2-1.2-1.21.4-2.9-3.10.5-0.4-0.10.30.2
Bone: cortical thickness0.50.61.20.80.80.80.7-0.6-0.1-0.61.1-1.1-1.01.00.5
Bone: cortical tissue density2.02.75.8-2.2-2.1-1.8-2.12.2-2.0-2.4-0.10.20.2-0.21.2
Condit. Reinf. active minus inactive responses0.70.83.60.1-0.00.3-0.40.5-0.0-0.81.1-1.1-1.11.11.9
Condit. Reinf. active-inactive response ratio1.11.23.30.40.30.60.00.1-0.3-1.11.6-1.5-1.51.51.8
Condit. Reinf. active responses0.50.63.30.20.00.4-0.30.40.5-0.30.8-0.9-0.90.91.8
Condit. Reinf. inactive responses0.10.10.80.30.20.30.1-0.20.90.7-0.20.10.0-0.10.2
Incentive salience index mean0.30.41.90.40.40.70.1-0.10.80.20.6-0.6-0.70.61.4
Condit. Reinf. lever presses0.10.20.6-0.2-0.10.2-0.20.10.80.7-0.60.60.4-0.50.2
Condit. Reinf. active minus inactive responses0.91.22.80.2-0.1-0.1-0.20.30.0-0.71.7-1.7-1.61.71.6
Condit. Reinf. active-inactive response ratio0.50.61.50.50.20.10.2-0.20.50.21.2-1.2-1.21.20.7
Condit. Reinf. active responses0.91.33.6-0.2-0.4-0.4-0.60.7-0.3-1.11.5-1.5-1.51.51.9
Condit. Reinf. inactive responses0.30.41.40.30.40.50.3-0.20.3-0.20.8-0.9-0.80.81.2
Condit. Reinf. lever presses0.30.41.2-0.1-0.2-0.2-0.30.40.0-0.40.9-0.9-0.91.01.1
Condit. Reinf. lever reinforcers received0.81.23.3-0.1-0.3-0.3-0.50.5-0.2-1.01.5-1.5-1.51.51.8
Conditioned reinforcement - actives0.40.71.70.81.10.91.3-1.20.40.30.8-0.8-0.70.7-0.3
Conditioned reinforcement - inactives0.10.20.6-0.7-0.2-0.4-0.30.3-0.7-0.70.1-0.10.00.00.0
Conditioned locomotion0.60.72.2-1.3-0.7-0.9-0.40.5-1.5-1.5-0.40.40.6-0.5-0.2
Patch foraging indifference point 0 sec0.91.74.21.81.42.11.4-1.41.91.70.4-0.5-0.60.50.5
Patch foraging indifference point AUC0.40.61.50.60.60.30.9-1.00.81.2-0.30.30.3-0.3-1.1
Delay disc. indifference point, 0s delay0.30.41.1-0.3-0.3-0.4-0.50.5-0.2-0.60.7-0.7-0.70.71.0
Delay disc. indifference point, 16s delay0.20.20.70.50.50.10.6-0.5-0.1-0.1-0.10.20.2-0.2-0.9
Delay disc. indifference point, 2s delay0.10.20.40.10.1-0.10.1-0.00.2-0.10.6-0.6-0.60.60.6
Delay disc. indifference point, 24s delay1.71.94.31.81.61.41.6-1.62.11.90.5-0.6-0.70.60.2
Delay disc. indifference point, 4s delay0.20.20.60.1-0.10.1-0.0-0.00.60.8-0.60.60.5-0.5-0.4
Delay disc. indifference point, 8s delay1.11.32.81.71.41.21.5-1.51.41.30.6-0.6-0.70.60.0
Indifference point function ln k0.10.10.40.10.10.0-0.10.1-0.2-0.60.3-0.3-0.30.30.6
Indifference point function log k0.10.10.40.10.10.0-0.10.1-0.2-0.60.3-0.3-0.30.30.6
Patch foraging total patch changes 0 sec0.91.63.91.71.42.01.4-1.41.81.70.2-0.3-0.40.30.4
Patch foraging total patch changes 12 sec1.01.42.41.51.31.51.2-1.31.51.50.7-0.8-0.80.80.3
Patch foraging total patch changes 18 sec0.60.91.11.00.90.80.9-0.90.90.71.1-1.1-1.11.10.5
Patch foraging total patch changes 24 sec1.22.03.51.91.51.71.6-1.61.51.31.2-1.2-1.31.30.3
Patch foraging total patch changes 6 sec1.42.25.52.01.52.11.6-1.72.22.30.1-0.1-0.30.2-0.2
Patch foraging time to switch 0 sec0.30.71.60.30.20.3-0.10.2-0.0-0.51.3-1.2-1.31.31.1
Patch foraging water rate 0 sec0.30.71.9-0.2-0.00.00.2-0.20.20.5-1.41.31.3-1.4-0.7
Patch foraging water rate 12 sec0.71.43.8-1.3-1.2-1.1-1.41.5-1.3-2.00.4-0.4-0.40.41.5
Patch foraging water rate 18 sec0.50.81.90.70.50.40.3-0.20.2-0.21.4-1.4-1.41.41.1
Patch foraging water rate 24 sec0.30.41.00.81.00.80.9-0.80.80.50.1-0.1-0.10.10.1
Patch foraging water rate 6 sec1.52.12.9-1.7-1.4-1.7-1.11.1-1.5-1.1-1.61.61.7-1.7-1.0
Seeking ratio, delayed vs. immediate footshock0.10.20.5-0.3-0.4-0.0-0.20.20.40.3-0.70.60.6-0.60.2
Distance traveled before self-admin0.10.10.30.50.20.30.2-0.20.40.50.3-0.3-0.30.30.1
Distance traveled after self-admin1.31.63.91.71.31.61.3-1.32.01.80.6-0.6-0.80.70.4
Extensor digitorum longus weight0.10.20.70.20.20.40.2-0.30.20.6-0.60.60.6-0.6-0.8
Bone: elastic displacement1.11.33.2-1.4-1.3-1.8-1.11.0-1.2-0.4-0.90.90.9-0.9-1.1
Bone: elastic work0.81.12.5-0.9-0.6-0.9-0.60.5-0.90.0-1.31.31.4-1.3-1.6
Bone: endosteal estimation0.30.71.41.11.11.11.0-1.11.01.20.0-0.0-0.10.1-0.4
Bone: endosteal perimeter0.10.20.60.60.70.80.6-0.60.20.10.2-0.2-0.20.2-0.1
Epididymis fat weight1.44.97.32.72.32.42.2-2.12.41.82.2-2.2-2.32.21.4
Delta time in closed arm before/after self-admin1.11.02.1-1.0-1.0-1.3-1.01.1-1.4-1.2-0.70.80.8-0.8-0.6
Delta time in open arm before/after self-admin2.72.76.80.70.70.90.4-0.20.4-0.62.4-2.4-2.42.42.6
Diff in mean of infusions in LGA sessions0.91.12.6-0.7-0.7-0.7-0.40.4-1.1-0.4-1.31.31.4-1.4-1.6
Delay discount exponential model param0.40.41.0-1.0-0.8-0.6-0.90.9-0.8-0.8-0.20.20.2-0.20.3
Extinction: sum of active levers before priming0.60.72.60.0-0.1-0.1-0.20.20.2-0.51.1-1.1-1.21.21.6
Active lever presses in extinction session 60.40.41.1-0.4-0.2-0.4-0.10.1-0.4-0.3-1.01.01.0-1.1-0.8
Bone: final force0.10.20.40.40.30.30.1-0.1-0.6-0.50.5-0.5-0.40.5-0.3
Bone: final moment0.10.10.30.40.30.40.2-0.2-0.6-0.30.4-0.4-0.30.4-0.4
Food consumed during 24 hour testing period2.43.37.11.41.01.20.5-0.40.8-0.32.6-2.6-2.72.72.6
Glucose0.91.53.0-1.4-1.5-1.6-1.51.6-1.5-1.70.2-0.2-0.10.20.8
Heart weight1.72.63.91.71.51.51.5-1.41.30.72.0-2.0-2.01.91.3
Delay discount hyperbolic model param0.30.30.7-0.9-0.7-0.5-0.80.8-0.8-0.7-0.10.10.1-0.10.2
Intermittent access intake day 1-15 change0.20.30.8-0.8-0.8-0.7-0.60.6-0.9-0.80.1-0.1-0.10.10.2
Intermittent access intake escalation0.20.51.1-1.1-0.9-0.8-0.80.8-1.0-0.9-0.00.10.1-0.10.2
Intermittent access intake escalation 20.20.20.9-0.6-0.5-0.4-0.30.3-0.9-0.7-0.00.10.2-0.1-0.4
Intermitt. access day 1 inactive lever presses0.93.57.1-2.5-2.1-2.0-2.12.1-2.7-2.4-1.11.21.3-1.2-0.1
Intermitt. access day 15 inactive lever presses1.22.45.2-2.0-2.0-1.9-2.32.3-1.6-1.4-0.70.70.6-0.60.6
Intermitt. access escalation Index0.30.40.9-0.8-0.8-0.8-1.00.9-0.2-0.1-0.50.50.4-0.4-0.0
Intermittent access day 1 total infusions1.21.93.21.81.61.51.5-1.51.41.11.3-1.3-1.31.30.5
Intermittent access day 15 total infusions0.50.71.70.30.30.40.3-0.2-0.1-0.41.3-1.3-1.21.21.2
Intermittent access terminal intake (last 3 days)0.40.51.20.20.10.20.2-0.1-0.2-0.41.1-1.1-1.01.10.9
Intermittent access total infusions0.70.91.70.90.70.70.7-0.70.40.01.3-1.3-1.31.31.0
Intermittent access day 1 locomotion0.30.40.80.80.90.80.9-0.80.30.30.6-0.5-0.50.50.1
Intermittent access day 15 total locomotion1.01.82.91.21.51.41.6-1.50.40.21.7-1.6-1.51.60.6
Intermittent access total locomotion0.10.20.3-0.00.40.30.4-0.4-0.3-0.40.6-0.5-0.40.50.3
Intermittent access standard deviation0.20.51.3-0.6-0.8-0.5-0.60.7-0.7-1.00.5-0.5-0.50.51.2
Left kidney weight3.516.228.45.35.14.84.8-4.84.73.92.8-2.8-2.92.80.7
Right kidney weight3.817.429.65.45.24.95.1-5.04.63.83.1-3.2-3.23.10.9
Cocaine induced anxiety0.10.10.3-0.30.2-0.20.1-0.1-0.3-0.5-0.20.20.3-0.3-0.3
Post-drug Anxiety0.20.20.60.50.80.40.7-0.70.20.00.3-0.3-0.20.2-0.1
Baseline Anxiety0.10.10.50.60.10.30.2-0.20.60.70.2-0.2-0.30.30.3
Tail length0.72.56.32.02.01.81.8-1.92.42.5-0.1-0.0-0.10.0-0.5
Length with tail1.04.310.12.62.52.42.5-2.62.73.2-0.30.20.1-0.2-1.5
Length without tail0.72.24.41.91.81.81.9-1.91.92.10.0-0.1-0.10.0-1.0
Times rat made contact with spout3.54.08.11.71.41.41.2-1.01.40.12.8-2.8-2.82.82.3
Lifetime Intake0.40.50.90.80.60.60.7-0.60.60.30.9-0.9-0.90.90.7
Liver weight, left4.26.910.03.22.82.72.5-2.52.71.72.8-2.9-2.92.91.6
Liver weight, right1.01.73.41.81.71.91.6-1.61.71.40.4-0.4-0.50.40.5
Locomotor activity0.71.13.90.20.3-0.10.00.10.3-0.41.5-1.5-1.51.52.0
Locomotor testing distance2.64.69.51.61.61.31.3-1.11.0-0.43.1-3.1-3.03.02.7
Locomotor testing rearing1.73.57.21.41.31.11.1-0.90.5-0.92.7-2.7-2.62.62.4
Locomotion in novel chamber0.40.51.0-0.9-0.8-0.9-0.80.8-0.7-1.00.0-0.0-0.00.00.7
Locomotion in novel chamber post-restriction1.01.63.8-0.0-0.1-0.1-0.20.00.91.6-2.01.91.7-1.8-1.5
Fecal boli incidents, locomotor time 10.20.31.2-0.2-0.2-0.3-0.0-0.0-0.20.4-0.60.60.6-0.6-1.1
Change in fecal boli incidents, locomotor task0.10.10.3-0.5-0.4-0.1-0.50.5-0.0-0.1-0.30.30.2-0.30.3
Time >=10cm from walls, locomotor time 13.03.26.3-1.4-1.3-1.1-1.00.9-1.4-0.3-2.42.52.5-2.5-2.1
Bouts of movement, locomotor time 10.80.91.71.00.90.80.8-0.70.50.01.3-1.3-1.21.30.5
Total resting periods, locomotor time 10.70.81.21.11.00.80.9-0.90.70.41.1-1.1-1.11.10.2
Rest time, locomotor task time 10.20.20.6-0.2-0.7-0.3-0.80.7-0.0-0.00.1-0.1-0.20.20.8
Distance moved, locomotor task time 10.30.40.90.81.00.80.8-0.70.3-0.20.5-0.5-0.50.50.4
Vertical activity count, locomotor time 10.10.20.70.50.80.50.7-0.6-0.4-0.80.2-0.2-0.00.0-0.3
Time >=10cm from walls, locomotor time 20.20.20.6-0.2-0.1-0.0-0.20.10.20.4-0.80.80.7-0.8-0.4
Bouts of movement, locomotor time 20.10.10.3-0.4-0.2-0.2-0.30.3-0.10.1-0.60.60.5-0.5-0.3
Total resting periods, locomotor time 20.10.10.3-0.5-0.4-0.3-0.50.5-0.10.0-0.40.40.3-0.4-0.0
Rest time, locomotor task time 21.01.33.0-0.4-0.8-0.6-1.01.1-0.8-1.21.4-1.3-1.31.41.7
Distance moved, locomotor task time 20.50.51.00.91.00.90.9-0.80.7-0.10.6-0.7-0.60.60.8
Vertical activity count, locomotor time 20.20.30.50.70.70.60.4-0.30.2-0.50.5-0.5-0.50.50.7
Light reinforcement 10.71.62.91.51.51.71.7-1.71.51.20.8-0.8-0.80.70.1
Light reinforcement 20.10.10.40.00.10.10.3-0.30.10.5-0.50.50.5-0.5-0.6
Bone: marrow area0.30.71.51.11.11.11.0-1.11.01.20.0-0.0-0.10.0-0.4
Bone: maximum diameter0.30.61.41.01.21.21.2-1.1-0.2-0.10.4-0.3-0.20.3-0.9
Bone: maximum force0.20.40.90.70.60.70.4-0.3-0.3-0.30.9-0.9-0.80.9-0.0
Bone: maximum moment0.20.40.60.80.60.80.5-0.4-0.2-0.10.8-0.7-0.70.8-0.1
Mean time between licks in bursts0.41.12.11.41.11.01.3-1.40.81.30.6-0.5-0.50.5-1.2
Mean num. licks in bursts1.01.53.01.01.01.31.1-0.9-0.0-0.81.7-1.7-1.51.61.1
Cd content in liver0.60.71.50.10.00.2-0.10.2-0.5-1.11.2-1.2-1.11.21.0
Co content in liver0.91.02.20.91.01.00.5-0.40.5-0.21.3-1.3-1.31.31.5
Cu content in liver0.10.10.2-0.4-0.2-0.5-0.40.4-0.3-0.4-0.10.10.1-0.10.2
Fe content in liver0.70.91.2-1.1-1.0-0.9-1.11.1-1.0-0.7-1.01.01.0-1.0-0.5
K content in liver0.60.51.30.91.11.00.9-0.90.90.60.4-0.4-0.40.40.3
Mg content in liver0.40.41.2-0.8-0.6-0.8-0.80.8-1.0-1.10.1-0.1-0.10.10.3
Mn content in liver1.82.03.4-1.7-1.8-1.7-1.71.8-1.8-1.8-0.80.80.9-0.8-0.1
Na content in liver0.50.51.20.71.11.01.0-1.00.80.70.1-0.1-0.10.1-0.4
Rb content in liver0.40.41.00.20.30.10.2-0.1-0.3-0.71.0-1.0-0.90.90.8
Se content in liver1.41.62.7-1.7-1.5-1.3-1.61.7-1.4-1.5-0.80.80.8-0.80.7
Sr content in liver0.20.20.40.00.10.60.2-0.20.10.2-0.60.60.6-0.6-0.4
Zn content in liver0.10.10.4-0.4-0.1-0.3-0.30.4-0.4-0.60.1-0.1-0.10.10.4
Bone: minimum diameter1.01.96.1-1.6-1.5-1.4-1.41.5-2.5-2.3-0.20.30.5-0.4-0.2
Time in familiar zone, hab. session 10.00.00.1-0.3-0.2-0.3-0.20.20.20.20.0-0.0-0.10.10.1
Time in novel zone, hab. session 12.22.24.12.01.82.01.5-1.51.30.91.4-1.4-1.41.40.4
Total zone transitions, hab. session 10.81.11.7-1.2-1.3-1.2-1.31.2-0.4-0.2-1.21.21.1-1.20.0
Total locomotion distance, hab. session 10.91.32.2-1.1-1.4-1.0-1.11.0-0.40.1-1.51.51.4-1.4-1.1
Locomotion velocity, hab. session 11.82.54.0-1.6-1.7-1.5-1.41.3-1.0-0.4-2.02.02.0-2.0-1.4
Time in familiar zone, hab. session 21.11.11.91.41.31.11.3-1.30.90.61.1-1.1-1.01.00.0
Time in novel zone, hab. session 20.10.10.4-0.1-0.1-0.0-0.30.30.10.00.1-0.1-0.20.10.6
Total zone transitions, hab. session 20.20.31.30.1-0.1-0.1-0.20.11.11.2-0.40.30.2-0.30.3
Total locomotion distance, hab. session 20.10.20.6-0.5-0.8-0.7-0.60.6-0.1-0.0-0.20.20.1-0.10.1
Locomotion velocity, hab. session 20.10.20.6-0.5-0.8-0.7-0.60.60.10.2-0.40.30.2-0.30.0
Novel to familiar place preference ratio0.20.31.0-0.5-0.5-0.4-0.50.6-0.8-1.0-0.00.00.1-0.00.6
Novelty place preference0.20.31.2-0.4-0.3-0.2-0.40.5-0.8-1.10.2-0.1-0.10.10.8
Time in novel zone, NPP test0.30.31.3-0.4-0.4-0.2-0.50.6-0.9-1.20.1-0.1-0.10.10.8
Total zone transitions, NPP test0.71.01.7-0.9-1.1-1.1-1.21.10.20.6-1.31.21.0-1.1-0.2
Total locomotion distance, NPP test1.42.03.9-1.6-2.0-1.9-1.91.8-1.0-0.5-1.21.21.1-1.2-0.4
Locomotion velocity, NPP test1.31.93.7-1.5-1.9-1.8-1.81.7-0.9-0.4-1.31.21.2-1.2-0.4
Intraocular pressure3.85.49.3-3.0-2.9-2.7-2.82.8-2.3-2.3-1.91.81.8-1.80.5
Delta distance traveled before/after self-admin1.11.22.21.41.31.51.3-1.31.51.30.4-0.4-0.50.40.1
Delta ambulatory time before/after self-admin1.31.62.81.51.41.51.3-1.31.71.21.0-1.1-1.11.10.8
Parametrial fat weight0.10.10.20.30.40.30.3-0.30.40.10.4-0.5-0.50.40.4
Pavlov. Cond. lever latency0.20.30.50.1-0.0-0.1-0.10.2-0.5-0.70.7-0.7-0.60.70.6
Pavlov. Cond. magazine entry latency2.02.65.62.01.92.11.9-2.02.32.40.0-0.1-0.20.1-0.7
Pavlov. Cond. change in total contacts0.40.40.80.70.70.90.9-0.90.70.6-0.10.10.1-0.1-0.4
Pavlov. Cond. index score0.91.22.51.21.21.41.3-1.41.51.6-0.30.20.2-0.2-0.7
Pavlov. Cond. latency score0.70.92.10.91.01.11.1-1.21.31.4-0.30.30.2-0.3-0.9
Pavlov. Cond. lever contacts0.30.40.9-0.4-0.3-0.2-0.10.10.00.2-1.00.90.9-0.9-0.6
Pavlov. Cond. magazine entry number3.64.68.4-2.8-2.6-2.9-2.72.7-2.8-2.5-0.80.80.9-0.80.2
Pavlov. Cond. intertrial magazine entries0.60.71.2-1.1-1.0-0.9-1.01.0-0.9-0.8-0.60.60.6-0.60.3
Pavlov. Cond. lever-magazine prob. diff.0.80.92.31.01.01.21.1-1.11.41.5-0.50.40.3-0.4-0.7
Pavlov. Cond. response bias1.51.83.91.61.71.91.7-1.72.01.8-0.0-0.1-0.10.0-0.3
Pavlov. Cond. lever latency0.20.31.2-0.10.0-0.20.2-0.2-0.10.4-0.70.70.7-0.7-1.1
Pavlov. Cond. magazine entry latency3.64.46.32.52.42.32.0-1.91.81.02.3-2.3-2.32.31.1
Pavlov. Cond. change in total contacts0.10.20.60.20.30.30.1-0.10.1-0.10.8-0.8-0.70.80.4
Pavlov. Cond. index score1.41.83.11.41.31.41.0-0.90.90.21.8-1.8-1.71.81.3
Pavlov. Cond. latency score1.82.33.71.61.51.61.2-1.11.10.31.9-1.9-1.91.91.4
Pavlov. Cond. lever contacts0.30.51.70.0-0.10.1-0.30.3-0.0-0.60.9-0.9-0.90.91.3
Pavlov. Cond. magazine entry number2.73.45.0-2.1-2.1-1.9-1.81.7-1.2-0.5-2.22.22.2-2.2-0.9
Pavlov. Cond. intertrial magazine entries0.71.01.6-1.1-1.1-1.2-0.60.5-0.8-0.2-1.21.21.2-1.2-1.0
Pavlov. Cond. lever-magazine prob. diff.1.82.34.21.51.41.41.1-1.01.00.22.1-2.1-2.02.11.4
Pavlov. Cond. response bias0.50.71.40.50.50.60.3-0.20.2-0.41.2-1.2-1.21.21.0
Time in closed arm before self-admin0.81.01.7-1.1-1.1-0.8-0.90.8-0.7-0.2-1.31.31.3-1.3-0.8
Time in closed arm after self-admin1.41.52.2-1.1-1.3-1.5-1.21.1-1.2-0.5-1.41.41.4-1.4-1.2
Time in open arm before self-admin1.92.13.41.91.81.51.7-1.81.81.80.9-0.9-1.00.9-0.1
Time in open arm after self-admin4.04.46.41.91.92.11.6-1.52.11.12.4-2.4-2.52.52.4
Bone: periosteal estimation0.10.20.80.10.30.30.3-0.3-0.9-0.70.10.00.2-0.1-0.7
Bone: periosteal perimeter0.20.31.10.20.40.30.5-0.4-1.0-0.70.1-0.00.2-0.0-1.1
Bone: post-yield work0.20.30.70.70.50.70.7-0.80.70.8-0.20.20.2-0.2-0.6
Progressive ratio test 1 active lever presses0.10.10.30.50.20.20.4-0.40.30.20.4-0.4-0.40.40.2
Progressive ratio test 1 breakpoint0.10.10.20.40.10.00.3-0.30.10.10.4-0.4-0.40.40.2
Progressive ratio test 1 inactive lever presses0.10.20.4-0.3-0.3-0.4-0.30.2-0.10.1-0.60.60.6-0.6-0.2
Progressive ratio test 2 active lever presses1.61.92.91.51.41.31.4-1.40.80.41.7-1.7-1.61.60.9
Progressive ratio test 2 breakpoint1.51.72.81.31.21.21.3-1.20.70.41.7-1.7-1.61.61.0
Progressive ratio test 2 inactive lever presses0.30.50.80.80.80.80.9-0.80.30.10.9-0.9-0.80.80.4
Incentive Sensitization - Responses2.53.64.42.12.02.12.0-1.91.61.12.1-2.1-2.12.11.1
Incentive Sensitization - Breakpoint2.73.54.42.01.92.01.9-1.81.61.12.1-2.1-2.12.11.2
Sum of active levers in priming session hrs 5-60.10.10.30.30.10.30.2-0.20.40.6-0.20.20.2-0.2-0.3
Progressive ratio0.60.92.00.70.60.80.4-0.40.6-0.11.3-1.3-1.41.31.4
Food seeking constrained by brief footshock1.31.63.31.81.41.31.2-1.31.81.80.7-0.8-0.90.8-0.2
Seeking ratio, punishment vs. effort0.40.61.80.30.30.00.3-0.40.61.2-0.90.90.8-0.9-1.3
Retroperitoneal fat weight0.62.64.41.61.31.31.1-1.01.50.82.0-2.0-2.12.11.7
Reaction time number correct0.61.12.3-1.3-1.2-1.2-1.31.4-1.3-1.5-0.50.50.6-0.60.6
Reaction time mean minus median0.10.10.3-0.4-0.5-0.6-0.60.50.10.30.1-0.1-0.20.20.3
Reaction time mean minus median AUC0.10.20.40.20.10.0-0.10.00.50.60.6-0.6-0.60.70.5
Reaction time num false alarms0.20.30.80.90.60.60.8-0.70.40.30.4-0.4-0.40.4-0.5
Reaction time num false alarms AUC0.30.51.11.00.70.70.9-0.90.60.50.5-0.5-0.40.4-0.6
Reaction time trials correct on left0.61.12.3-1.3-1.2-1.2-1.31.4-1.3-1.5-0.50.50.6-0.60.6
Reaction time trials on left0.71.32.7-1.4-1.4-1.3-1.41.5-1.5-1.7-0.50.50.5-0.50.7
Reaction time mean1.01.52.5-1.0-1.3-1.3-1.51.5-1.2-1.61.0-0.9-0.91.01.3
Reaction time mean AUC0.71.11.8-0.9-1.2-1.2-1.31.3-1.0-1.20.8-0.7-0.70.81.0
Median of all reaction times1.01.42.8-0.8-1.1-1.1-1.21.3-1.2-1.71.1-1.1-1.01.11.1
Reaction time omissions1.82.75.1-1.2-1.6-1.5-1.91.9-1.5-2.11.3-1.3-1.31.42.3
Reaction time false alarm rate1.01.42.51.61.31.31.5-1.61.31.30.6-0.6-0.60.6-0.9
Reaction time premature initiation rate2.94.07.52.62.32.32.4-2.42.62.71.1-1.2-1.31.2-0.3
Reaction time premature initiations0.71.22.01.41.21.21.2-1.21.41.40.7-0.8-0.80.80.2
Std. dev. reaction times0.40.81.8-1.0-1.2-1.2-1.31.3-0.5-0.50.4-0.4-0.50.50.9
Reaction time trials completed0.71.32.7-1.4-1.4-1.3-1.41.5-1.5-1.7-0.50.50.5-0.50.7
Reaction time trials AUC0.71.33.2-1.3-1.3-1.2-1.41.4-1.5-1.8-0.30.30.4-0.40.8
Run reversals in cocaine runway, females0.50.51.2-0.9-0.7-1.1-0.50.5-0.40.1-0.80.80.8-0.8-0.9
Run reversals in cocaine runway, males0.80.91.6-1.0-0.9-0.8-0.80.7-0.50.1-1.31.31.2-1.2-0.7
Latency to leave start box in cocaine runway1.51.83.9-1.1-0.8-0.9-0.60.5-0.60.3-2.02.02.0-2.0-1.3
Latency to leave start box in cocaine runway, F1.01.12.6-0.6-0.3-0.4-0.10.0-0.40.1-1.61.61.6-1.6-1.5
Latency to leave start box in cocaine runway, M0.50.40.7-0.8-0.7-0.8-0.60.5-0.30.3-0.80.80.7-0.7-0.3
Std. dev. time between licks in bursts1.11.43.11.61.51.31.4-1.51.51.80.2-0.2-0.30.2-0.8
Total sessions with >9 infusions0.10.10.30.60.20.30.2-0.20.60.40.3-0.3-0.40.30.5
Short access day 1 total inactive lever presses0.00.10.20.10.10.00.2-0.20.10.10.3-0.3-0.20.20.5
Short access day 10 total inactive lever presses0.41.01.7-1.3-1.0-0.9-0.80.8-0.9-0.6-1.21.21.2-1.2-0.4
Short access day 1 total infusions0.10.10.30.1-0.1-0.0-0.10.00.30.5-0.40.40.3-0.4-0.2
Short access day 10 total infusions0.20.20.5-0.0-0.2-0.4-0.20.3-0.6-0.70.6-0.5-0.50.50.4
Short access total infusions0.10.10.30.50.20.10.2-0.20.50.50.2-0.2-0.20.20.2
Short access day 1 locomotion0.10.10.2-0.2-0.2-0.2-0.20.2-0.3-0.40.1-0.1-0.10.10.4
Short access day 10 total locomotion3.25.910.5-3.2-3.0-2.8-2.93.0-3.0-2.8-1.41.51.5-1.50.5
Short access total locomotion1.21.42.6-1.5-1.5-1.4-1.41.4-1.6-1.5-0.70.70.7-0.70.3
One hour access (0.3 mA shock)0.20.20.40.50.40.50.6-0.50.1-0.00.6-0.6-0.50.50.5
Compulsive drug intake0.20.31.40.30.20.20.1-0.10.91.2-0.50.50.4-0.4-0.3
One hour access (shock baseline)0.20.40.80.20.30.30.4-0.3-0.6-0.80.9-0.8-0.70.80.6
Social response proportion6.27.012.3-3.5-3.4-3.4-3.23.1-2.8-2.0-2.02.12.1-2.0-0.8
Social responses1.62.14.2-2.0-1.9-2.0-1.91.9-1.6-1.5-0.70.70.7-0.70.3
Social time0.40.61.2-1.0-0.9-0.9-1.11.0-0.6-0.5-0.70.60.6-0.60.2
Soleus weight0.72.04.80.40.80.70.8-0.90.61.7-1.81.81.8-1.8-2.2
Bone: stiffness0.50.81.81.21.11.30.7-0.60.3-0.01.1-1.0-1.01.00.6
Tibialis anterior weight2.48.213.4-3.7-3.5-3.3-3.43.3-2.6-1.6-2.72.82.7-2.7-0.7
Time to tail flick, vehicle, before self-admin0.10.10.4-0.10.20.10.2-0.2-0.1-0.0-0.40.40.4-0.4-0.6
Time to tail flick, vehicle, after self-admin0.10.20.40.10.50.40.7-0.6-0.4-0.50.5-0.4-0.30.3-0.3
Time to tail flick, test, before self-admin0.60.71.3-0.7-0.8-0.7-0.70.8-0.9-1.20.7-0.7-0.60.71.0
Time to tail flick, test, after self-admin0.91.02.1-1.5-1.2-1.0-1.31.3-1.0-1.1-0.50.50.5-0.50.7
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.10.1-0.10.1-0.1-0.4-0.60.7-0.6-0.60.60.4
Delta time to tail flick, test, before/after SA0.90.92.3-0.7-0.4-0.4-0.50.4-0.20.2-1.51.51.4-1.5-1.0
Tibia length0.30.71.51.11.21.11.2-1.20.20.30.7-0.7-0.60.6-0.5
Ambulatory time before self-admin0.10.10.40.60.30.50.3-0.30.50.60.2-0.2-0.30.3-0.1
Ambulatory time after self-admin0.81.01.91.21.11.30.9-0.91.41.00.7-0.8-0.80.80.6
Bone: tissue strength0.10.10.20.30.10.40.2-0.2-0.2-0.10.5-0.4-0.40.4-0.3
Total heroin consumption0.20.30.8-0.5-0.5-0.3-0.30.3-0.9-0.6-0.40.40.5-0.5-0.7
Bone: trabecular number0.00.00.10.20.20.20.2-0.20.20.2-0.20.20.2-0.2-0.1
Bone: trabecular spacing0.60.81.9-0.7-0.9-1.0-0.91.0-1.0-1.40.7-0.6-0.60.60.8
Bone: trabecular thickness2.32.84.3-2.1-1.6-1.7-1.51.5-1.5-0.7-2.02.02.0-2.0-1.2
Bone: trabecular tissue density0.20.41.2-0.5-0.7-0.6-1.01.00.0-0.20.1-0.1-0.20.21.1
Water consumed over 24 hours3.74.99.22.01.71.81.1-1.01.70.32.9-3.0-3.03.02.9
Number of responses in last shaping day0.00.00.50.0-0.1-0.0-0.10.10.2-0.2-0.10.0-0.0-0.00.7