Hub : Genes

Emid1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Emid1 0.08 0.05 8.3e-08 0.04 0.06 0.06 0.06 4.3e-05 3.3e-07 1.8e-07 1.3e-07
2 PL gene expression Emid1 0.35 0.14 0.0e+00 0.25 0.28 0.28 0.28 9.0e-27 5.7e-31 6.7e-31 6.2e-31
3 Brain alternative TSS NM_001401620.1 0.07 0.05 6.1e-05 0.01 0.05 0.04 0.03 2.7e-02 3.3e-05 1.1e-04 3.7e-04
4 Brain alternative TSS XM_008770369.3 0.07 0.05 6.2e-05 0.01 0.05 0.04 0.03 2.7e-02 3.3e-05 1.2e-04 4.2e-04
5 Brain alternative TSS NM_001401620.1 0.07 0.05 6.5e-05 0.01 0.05 0.04 0.03 2.5e-02 3.4e-05 1.1e-04 4.1e-04
6 Brain alternative TSS XM_008770369.3 0.07 0.05 6.5e-05 0.01 0.05 0.04 0.03 2.4e-02 3.4e-05 1.1e-04 4.4e-04
7 Brain gene expression Emid1 0.3 0.14 0.0e+00 0.23 0.18 0.24 0.22 2.5e-21 2.9e-16 6.2e-22 5.8e-20
8 Adipose mRNA stability Emid1 0.1 0.09 1.1e-03 0.03 0.03 0.01 0.02 6.0e-04 7.9e-04 3.2e-02 1.8e-03
9 IL gene expression Emid1 0.37 0.19 7.5e-04 0.15 0.14 0.14 0.15 2.1e-04 3.3e-04 2.9e-04 1.9e-04
10 pVTA gene expression Emid1 0.13 0.09 3.9e-03 0.07 0.05 0.04 0.04 6.2e-04 3.7e-03 7.7e-03 5.0e-03
11 BLA gene expression Emid1 0.41 0.17 7.0e-13 0.22 0.24 0.24 0.24 4.0e-12 2.2e-13 7.4e-13 5.9e-13
12 NAcc gene expression Emid1 0.3 0.13 0.0e+00 0.15 0.16 0.16 0.16 3.3e-17 5.5e-18 3.4e-18 1.0e-17
13 OFC mRNA stability Emid1 0.49 0.2 7.0e-04 0.08 0.09 0.07 0.08 5.4e-03 3.8e-03 1.1e-02 6.3e-03
14 Brain mRNA stability Emid1 0.13 0.08 1.4e-04 0.05 0.03 0.05 0.04 1.5e-05 1.6e-03 3.1e-05 4.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.41.40.1-0.00.8-0.80.8-0.80.3-0.2-0.20.3-0.30.5-0.51.2
Area under the delay curve2.32.43.9-1.9-2.0-1.51.5-1.51.51.7-1.6-1.61.7-1.61.4-1.4-0.1
BMI with tail0.00.00.10.40.10.0-0.00.0-0.0-0.30.10.1-0.20.1-0.10.1-0.3
BMI without tail0.30.61.20.1-0.40.9-0.90.9-0.90.3-0.7-0.71.0-0.50.9-0.91.1
Body weight0.93.96.3-2.4-2.5-1.31.3-1.31.32.3-2.3-2.32.3-2.42.1-2.10.0
Weight adjusted by age1.31.53.1-1.1-1.40.1-0.10.1-0.11.4-1.5-1.51.8-1.41.5-1.51.3
Bone surface0.20.40.9-0.8-0.7-0.20.2-0.20.20.8-0.6-0.60.6-0.90.7-0.70.4
Bone volume0.30.51.0-0.8-0.7-0.00.00.00.00.9-0.7-0.70.7-1.00.9-0.90.7
Breakpoint value in progressive ratio session1.01.11.7-1.2-1.3-1.01.0-1.01.01.2-1.1-1.11.3-1.11.0-0.9-0.1
Number of licking bursts2.32.74.5-2.1-2.0-1.21.2-1.21.22.0-1.8-1.81.8-2.01.7-1.70.1
Context. condit. distance diff. score2.63.15.12.32.21.7-1.71.7-1.7-2.01.81.8-1.72.0-1.51.50.3
Locomotion velocity, session 11.92.14.50.50.9-1.41.4-1.41.4-1.21.51.5-1.51.2-1.71.7-2.1
Locomotion distance, session 10.50.61.60.50.51.2-1.21.3-1.2-0.20.10.1-0.20.20.1-0.11.1
Locomotion velocity, session 21.51.73.20.40.9-1.31.3-1.31.3-1.11.41.4-1.51.0-1.61.6-1.8
Locomotion distance, session 21.52.13.71.51.90.7-0.70.7-0.7-1.81.81.8-1.91.5-1.71.7-0.3
Locomotion velocity, session 31.51.73.01.51.51.7-1.71.7-1.7-1.11.01.0-1.11.0-0.80.70.9
Locomotion distance, session 30.10.10.5-0.4-0.10.1-0.00.1-0.00.3-0.1-0.10.1-0.70.2-0.30.4
Stereotopy head waving bouts, day 30.50.61.20.80.91.1-1.11.1-1.1-0.70.60.6-0.60.6-0.40.40.6
Stereotopy head waving duration, day 31.31.52.71.61.51.0-1.01.0-1.0-1.51.31.3-1.31.5-1.11.10.1
Locomotion velocity, session 70.10.10.2-0.5-0.2-0.40.4-0.40.40.3-0.1-0.10.1-0.30.1-0.1-0.3
Locomotion distance, session 70.40.51.00.50.90.1-0.10.1-0.1-0.81.01.0-1.00.8-1.00.9-0.6
Stereotopy head waving bouts, day 70.20.20.50.70.60.5-0.50.5-0.5-0.60.40.4-0.50.6-0.40.40.1
Stereotopy head waving duration, day 70.20.30.7-0.1-0.20.6-0.60.6-0.60.3-0.5-0.50.4-0.30.6-0.50.8
Locomotion velocity, session 82.02.34.01.51.90.2-0.20.2-0.2-1.92.02.0-2.01.7-1.91.9-0.9
Locomotion distance, session 85.58.012.73.53.62.5-2.52.5-2.5-3.33.03.0-3.13.2-2.72.60.2
Degree of sensitization distance2.12.14.11.61.70.4-0.40.4-0.4-1.81.81.8-1.72.0-1.71.7-1.0
Degree of sensitization stereotypy0.10.10.2-0.2-0.5-0.10.1-0.10.10.4-0.5-0.50.4-0.20.4-0.40.1
Conditioned locomotion0.91.02.80.80.61.7-1.71.7-1.7-0.30.00.0-0.20.30.1-0.21.2
Cocaine response after cond. corrected1.31.52.4-1.5-1.5-1.01.0-1.01.01.4-1.4-1.41.5-1.31.2-1.2-0.1
Cocaine response after cond. not corrected2.12.34.0-1.7-1.9-0.70.7-0.70.71.9-1.9-1.92.0-1.71.8-1.70.4
Cocaine response before conditioning0.20.30.70.50.30.8-0.80.8-0.8-0.20.10.1-0.00.20.1-0.10.8
Saline control response0.81.12.31.11.30.3-0.30.3-0.3-1.21.31.3-1.51.1-1.31.2-0.7
Bone: connectivity density0.20.30.90.30.30.9-0.80.9-0.9-0.00.00.0-0.1-0.00.2-0.20.9
Bone: cortical apparent density0.60.81.3-1.2-1.1-0.60.6-0.60.61.0-1.0-1.01.1-1.00.9-0.90.2
Bone: cortical area2.33.55.9-2.4-2.3-1.41.4-1.31.32.3-2.1-2.12.1-2.21.9-1.90.3
Bone: cortical porosity0.30.30.5-0.3-0.60.3-0.30.3-0.30.6-0.7-0.70.7-0.60.7-0.70.6
Bone: cortical porosity0.10.10.30.30.10.5-0.50.5-0.5-0.1-0.0-0.00.10.10.1-0.10.4
Bone: cortical thickness2.23.76.1-2.3-2.3-0.50.5-0.50.52.5-2.3-2.32.3-2.52.3-2.31.1
Bone: cortical thickness0.80.92.60.20.11.5-1.51.5-1.50.3-0.5-0.50.5-0.30.7-0.71.6
Bone: cortical tissue density0.60.71.3-1.1-1.1-0.70.7-0.70.71.0-0.9-0.91.0-1.00.8-0.80.1
Condit. Reinf. active minus inactive responses1.01.12.6-0.5-0.0-1.61.6-1.61.6-0.20.60.6-0.60.1-0.80.8-1.6
Condit. Reinf. active-inactive response ratio3.33.66.60.91.3-1.71.7-1.81.8-1.72.12.1-2.01.6-2.32.3-2.6
Condit. Reinf. active responses0.40.41.0-0.4-0.0-1.01.0-1.01.0-0.00.40.4-0.4-0.1-0.50.5-1.0
Condit. Reinf. inactive responses0.81.01.5-1.0-0.90.5-0.50.5-0.51.2-1.1-1.11.1-1.21.2-1.21.1
Incentive salience index mean0.60.72.0-0.9-0.5-1.41.4-1.41.40.30.00.00.1-0.4-0.20.2-1.0
Condit. Reinf. lever presses0.20.20.6-0.7-0.5-0.10.1-0.10.10.6-0.5-0.50.5-0.80.5-0.50.3
Condit. Reinf. active minus inactive responses0.40.51.10.80.90.4-0.40.4-0.4-0.80.90.9-1.10.9-0.90.8-0.3
Condit. Reinf. active-inactive response ratio0.10.10.30.20.4-0.20.2-0.20.2-0.30.40.4-0.60.4-0.50.5-0.5
Condit. Reinf. active responses0.70.92.01.01.20.3-0.30.3-0.3-1.11.21.2-1.41.1-1.21.1-0.5
Condit. Reinf. inactive responses0.81.02.01.21.20.3-0.30.3-0.3-1.21.21.2-1.41.2-1.21.2-0.5
Condit. Reinf. lever presses0.30.40.70.70.80.7-0.70.7-0.7-0.60.60.6-0.80.6-0.60.50.3
Condit. Reinf. lever reinforcers received0.50.81.70.91.10.3-0.30.3-0.3-0.91.11.1-1.31.0-1.11.0-0.4
Conditioned reinforcement - actives0.10.10.20.30.2-0.20.2-0.20.2-0.40.10.1-0.10.2-0.20.3-0.5
Conditioned reinforcement - inactives0.10.10.5-0.2-0.1-0.40.4-0.40.40.1-0.0-0.0-0.10.0-0.10.1-0.7
Conditioned locomotion0.10.10.30.2-0.30.2-0.20.2-0.2-0.2-0.6-0.60.5-0.30.6-0.50.3
Patch foraging indifference point 0 sec1.32.13.2-1.7-1.8-1.01.0-1.01.01.7-1.7-1.71.5-1.71.5-1.5-0.2
Patch foraging indifference point AUC0.10.10.5-0.3-0.2-0.50.6-0.50.50.10.00.0-0.2-0.2-0.20.1-0.7
Delay disc. indifference point, 0s delay0.90.91.7-1.1-1.3-0.60.6-0.60.61.2-1.1-1.11.3-1.11.1-1.10.4
Delay disc. indifference point, 16s delay1.61.63.9-1.3-1.2-2.02.0-2.02.00.8-0.7-0.70.8-0.70.4-0.3-1.1
Delay disc. indifference point, 2s delay2.12.44.0-1.5-1.70.1-0.10.1-0.11.9-1.9-1.92.0-1.72.0-2.01.4
Delay disc. indifference point, 24s delay0.70.71.8-1.0-0.7-1.31.3-1.31.30.6-0.3-0.30.4-0.50.2-0.1-0.7
Delay disc. indifference point, 4s delay2.72.84.7-2.0-2.2-0.80.8-0.80.82.1-1.9-1.92.1-2.01.9-1.90.7
Delay disc. indifference point, 8s delay0.70.71.2-1.0-0.9-1.11.1-1.11.10.7-0.6-0.60.6-0.70.5-0.5-0.4
Indifference point function ln k0.30.41.5-0.2-0.30.7-0.70.7-0.70.5-0.5-0.50.6-0.60.7-0.71.2
Indifference point function log k0.30.41.5-0.2-0.30.7-0.70.7-0.70.5-0.5-0.50.6-0.60.7-0.71.2
Patch foraging total patch changes 0 sec1.21.92.9-1.7-1.7-1.21.2-1.21.21.6-1.6-1.61.4-1.61.3-1.3-0.5
Patch foraging total patch changes 12 sec0.71.01.5-1.2-1.2-0.90.9-0.90.91.1-1.2-1.20.8-1.10.8-0.9-0.6
Patch foraging total patch changes 18 sec1.31.74.5-1.0-0.8-2.12.1-2.12.10.4-0.3-0.30.1-0.5-0.20.2-2.0
Patch foraging total patch changes 24 sec1.31.62.71.41.50.1-0.10.1-0.1-1.61.41.4-1.61.6-1.61.6-1.4
Patch foraging total patch changes 6 sec1.01.52.8-1.7-1.4-1.31.3-1.31.31.3-1.2-1.20.9-1.40.8-0.9-0.7
Patch foraging time to switch 0 sec0.20.30.70.80.60.7-0.70.7-0.7-0.70.40.4-0.40.8-0.30.40.3
Patch foraging water rate 0 sec0.91.42.4-1.5-1.3-1.51.5-1.51.51.2-0.8-0.81.0-1.30.6-0.6-1.0
Patch foraging water rate 12 sec0.00.00.1-0.2-0.1-0.10.1-0.10.10.10.10.10.1-0.40.1-0.10.2
Patch foraging water rate 18 sec1.11.52.6-0.3-0.71.3-1.31.4-1.40.9-1.1-1.11.3-0.81.5-1.41.6
Patch foraging water rate 24 sec0.30.40.90.10.3-0.80.8-0.80.8-0.50.70.7-0.50.5-0.70.7-0.9
Patch foraging water rate 6 sec0.30.50.9-0.8-0.8-0.20.2-0.10.10.9-0.8-0.80.9-0.90.9-0.90.5
Seeking ratio, delayed vs. immediate footshock0.20.20.80.70.40.2-0.20.2-0.2-0.50.40.4-0.20.9-0.30.4-0.1
Distance traveled before self-admin1.21.32.3-0.9-1.20.3-0.30.4-0.41.3-1.5-1.51.5-1.21.4-1.51.3
Distance traveled after self-admin0.80.91.6-0.8-1.00.4-0.40.4-0.41.1-1.1-1.11.1-1.01.2-1.30.9
Extensor digitorum longus weight2.49.415.8-4.0-3.8-2.32.3-2.22.23.7-3.4-3.43.4-3.73.1-3.00.3
Bone: elastic displacement0.50.61.70.60.21.3-1.31.3-1.3-0.1-0.2-0.20.20.10.4-0.41.0
Bone: elastic work0.91.22.0-0.5-0.80.9-0.90.9-0.91.0-1.2-1.21.3-0.91.4-1.41.4
Bone: endosteal estimation0.10.10.3-0.4-0.5-0.30.3-0.30.30.4-0.5-0.50.5-0.20.5-0.40.0
Bone: endosteal perimeter0.40.81.3-1.1-1.1-1.01.0-1.01.00.9-0.9-0.90.9-0.80.7-0.7-0.4
Epididymis fat weight0.40.92.40.50.21.5-1.51.6-1.50.1-0.4-0.40.2-0.20.5-0.61.3
Delta time in closed arm before/after self-admin3.53.46.02.52.12.2-2.22.1-2.1-2.01.51.5-1.52.0-1.31.20.9
Delta time in open arm before/after self-admin5.04.96.7-2.6-2.6-2.52.5-2.52.52.2-2.2-2.22.0-2.11.7-1.5-0.9
Diff in mean of infusions in LGA sessions0.20.20.40.50.10.7-0.70.7-0.7-0.1-0.2-0.20.00.40.1-0.10.3
Delay discount exponential model param2.12.23.61.81.91.4-1.41.4-1.3-1.71.51.5-1.61.6-1.41.40.0
Extinction: sum of active levers before priming0.40.41.3-0.3-0.2-1.01.0-1.01.00.10.00.0-0.2-0.1-0.20.3-1.2
Active lever presses in extinction session 60.60.51.1-0.4-0.80.2-0.20.2-0.20.8-1.0-1.01.0-0.71.0-0.90.7
Bone: final force0.30.40.6-0.8-0.8-0.40.4-0.40.40.8-0.7-0.70.8-0.80.7-0.70.3
Bone: final moment0.40.71.2-1.0-1.0-0.40.4-0.40.41.0-1.0-1.01.1-1.01.0-0.90.4
Food consumed during 24 hour testing period1.21.53.9-1.3-0.8-2.02.0-2.02.00.6-0.1-0.10.3-0.7-0.00.1-1.3
Glucose12.719.251.7-3.8-2.5-7.27.2-7.27.21.4-0.2-0.20.2-1.5-1.00.9-5.9
Heart weight1.01.42.70.91.4-0.20.2-0.20.2-1.31.61.6-1.51.2-1.61.6-0.9
Delay discount hyperbolic model param2.22.33.81.91.91.3-1.31.3-1.3-1.81.61.6-1.71.7-1.51.5-0.1
Intermittent access intake day 1-15 change0.60.61.30.00.2-1.11.1-1.11.1-0.60.50.5-0.40.2-0.70.8-1.1
Intermittent access intake escalation0.40.40.80.20.3-0.80.8-0.80.8-0.60.50.5-0.40.2-0.70.7-0.9
Intermittent access intake escalation 20.20.20.30.10.2-0.60.6-0.60.6-0.50.40.4-0.30.1-0.50.5-0.5
Intermitt. access day 1 inactive lever presses1.01.02.00.91.30.3-0.30.3-0.3-1.01.41.4-1.21.2-1.31.3-0.6
Intermitt. access day 15 inactive lever presses1.31.43.7-0.80.0-1.81.8-1.81.80.20.50.5-0.50.2-0.90.9-1.9
Intermitt. access escalation Index0.40.31.3-0.10.2-0.60.7-0.70.7-0.20.50.5-0.50.1-0.60.5-1.1
Intermittent access day 1 total infusions0.10.20.30.3-0.20.5-0.50.5-0.50.0-0.5-0.50.40.10.5-0.40.5
Intermittent access day 15 total infusions0.10.10.3-0.2-0.3-0.50.5-0.50.5-0.0-0.4-0.40.3-0.20.2-0.1-0.4
Intermittent access terminal intake (last 3 days)0.10.10.2-0.0-0.3-0.50.5-0.50.5-0.1-0.4-0.40.3-0.10.2-0.0-0.3
Intermittent access total infusions0.10.10.4-0.1-0.4-0.10.1-0.10.10.1-0.6-0.60.6-0.30.5-0.40.2
Intermittent access day 1 locomotion0.50.51.21.10.70.9-0.90.8-0.9-1.00.30.3-0.40.8-0.30.30.4
Intermittent access day 15 total locomotion0.20.20.6-0.1-0.2-0.80.8-0.80.8-0.1-0.1-0.10.10.1-0.10.2-0.7
Intermittent access total locomotion0.10.20.3-0.2-0.4-0.50.5-0.50.50.1-0.5-0.50.4-0.20.3-0.2-0.3
Intermittent access standard deviation0.90.92.21.41.10.9-0.90.9-0.9-1.50.90.9-0.80.9-0.80.70.5
Left kidney weight0.20.51.4-0.3-0.30.8-0.90.9-0.90.5-0.5-0.50.6-0.20.7-0.71.2
Right kidney weight0.71.95.11.00.52.3-2.32.3-2.3-0.3-0.2-0.20.30.40.6-0.61.9
Cocaine induced anxiety1.61.83.5-1.9-1.5-1.51.5-1.51.51.6-1.1-1.11.2-1.51.0-0.9-0.5
Post-drug Anxiety0.50.61.5-0.9-0.6-1.21.2-1.21.20.5-0.2-0.20.3-0.50.1-0.0-0.8
Baseline Anxiety0.60.61.10.60.8-0.30.3-0.30.3-0.90.90.9-1.01.0-1.01.1-0.8
Tail length2.16.311.3-2.6-2.9-0.10.1-0.10.13.0-3.2-3.23.4-2.93.2-3.21.8
Length with tail1.76.410.1-3.1-3.2-1.51.5-1.51.53.1-3.0-3.03.0-2.82.8-2.70.5
Length without tail0.81.73.4-1.6-1.3-1.81.8-1.81.81.1-0.9-0.90.7-1.00.5-0.5-1.1
Times rat made contact with spout1.61.83.60.30.8-1.41.4-1.51.5-1.01.41.4-1.31.0-1.61.6-1.9
Lifetime Intake0.30.40.9-0.2-0.70.1-0.10.1-0.10.3-0.9-0.90.9-0.50.9-0.80.6
Liver weight, left1.32.15.71.20.62.4-2.42.4-2.4-0.3-0.2-0.20.30.60.6-0.51.9
Liver weight, right1.83.17.62.01.32.7-2.72.7-2.7-1.10.50.5-0.51.3-0.10.11.9
Locomotor activity0.60.92.4-0.7-0.6-1.51.5-1.51.50.3-0.1-0.10.1-0.1-0.10.2-1.5
Locomotor testing distance0.71.12.0-1.0-1.10.4-0.40.4-0.41.2-1.4-1.41.3-1.01.4-1.40.8
Locomotor testing rearing1.21.83.5-1.9-1.6-1.31.3-1.31.31.5-1.4-1.41.1-1.51.1-1.1-0.6
Locomotion in novel chamber2.42.95.12.11.82.3-2.32.3-2.3-1.61.21.2-1.51.5-0.90.91.1
Locomotion in novel chamber post-restriction3.44.06.92.12.60.5-0.50.5-0.5-2.12.62.6-2.52.6-2.52.6-0.8
Fecal boli incidents, locomotor time 10.20.20.60.50.60.2-0.20.2-0.2-0.60.70.7-0.50.6-0.50.6-0.3
Change in fecal boli incidents, locomotor task0.50.51.00.10.4-0.80.8-0.80.8-0.60.70.7-0.60.6-0.80.8-1.0
Time >=10cm from walls, locomotor time 10.00.00.1-0.00.1-0.10.1-0.10.1-0.10.20.2-0.30.2-0.20.2-0.3
Bouts of movement, locomotor time 10.91.02.4-0.3-0.0-1.51.5-1.51.5-0.20.40.4-0.60.3-0.80.8-1.5
Total resting periods, locomotor time 11.21.32.70.10.5-1.41.4-1.41.4-0.70.90.9-1.00.7-1.21.2-1.7
Rest time, locomotor task time 10.40.40.70.00.4-0.80.8-0.80.8-0.40.70.7-0.60.3-0.80.8-0.8
Distance moved, locomotor task time 10.80.91.7-0.8-1.00.4-0.40.4-0.41.1-1.2-1.20.9-1.01.2-1.30.7
Vertical activity count, locomotor time 10.30.30.7-0.4-0.70.2-0.20.2-0.20.6-0.8-0.80.6-0.50.8-0.80.4
Time >=10cm from walls, locomotor time 20.20.20.70.50.3-0.10.0-0.10.0-0.50.40.4-0.30.8-0.40.5-0.5
Bouts of movement, locomotor time 20.00.00.10.20.10.2-0.20.2-0.2-0.1-0.0-0.00.20.10.1-0.00.2
Total resting periods, locomotor time 20.00.00.00.20.10.0-0.00.0-0.0-0.20.00.00.10.10.00.10.1
Rest time, locomotor task time 20.10.10.20.10.4-0.00.0-0.00.1-0.30.50.5-0.40.3-0.50.4-0.2
Distance moved, locomotor task time 20.00.10.10.30.20.1-0.10.0-0.1-0.30.20.2-0.40.3-0.30.2-0.3
Vertical activity count, locomotor time 20.00.00.00.2-0.10.1-0.10.1-0.1-0.0-0.0-0.00.1-0.00.1-0.1-0.0
Light reinforcement 10.40.81.4-0.8-0.80.4-0.40.5-0.41.0-1.2-1.20.9-1.11.1-1.20.9
Light reinforcement 20.70.91.9-0.6-0.90.5-0.50.5-0.50.9-1.4-1.41.1-0.81.3-1.21.0
Bone: marrow area0.00.10.1-0.2-0.4-0.20.2-0.20.20.3-0.3-0.30.4-0.10.3-0.2-0.1
Bone: maximum diameter2.75.08.7-2.8-2.4-3.03.0-2.92.92.1-1.6-1.61.6-2.11.2-1.2-1.3
Bone: maximum force0.40.61.0-0.9-0.9-0.20.2-0.10.11.0-1.0-1.01.0-1.01.0-1.00.6
Bone: maximum moment0.61.11.8-1.1-1.2-0.20.2-0.10.11.3-1.3-1.31.4-1.31.3-1.30.7
Mean time between licks in bursts1.21.73.6-0.30.2-1.91.9-1.91.9-0.50.90.9-0.80.6-1.21.2-1.8
Mean num. licks in bursts3.33.96.42.12.30.1-0.10.1-0.1-2.42.52.5-2.42.4-2.52.5-1.3
Cd content in liver0.20.20.60.30.30.7-0.70.7-0.7-0.10.00.00.00.30.1-0.10.5
Co content in liver0.10.10.1-0.2-0.10.3-0.30.3-0.30.2-0.2-0.20.1-0.30.2-0.30.3
Cu content in liver0.30.30.7-0.9-0.5-0.70.7-0.70.70.5-0.3-0.30.2-0.50.2-0.2-0.7
Fe content in liver2.63.25.41.31.6-0.90.9-0.90.9-2.02.22.2-2.31.8-2.32.3-2.0
K content in liver2.62.54.5-1.4-1.60.6-0.60.6-0.61.9-2.0-2.02.0-1.82.1-2.01.5
Mg content in liver0.60.61.2-1.0-0.80.0-0.00.0-0.01.0-1.0-1.00.8-1.11.0-0.90.5
Mn content in liver1.92.23.6-0.9-1.11.1-1.11.1-1.11.5-1.7-1.71.6-1.61.9-1.81.8
Na content in liver2.42.55.2-1.8-1.5-2.32.3-2.32.31.3-0.9-0.90.9-1.30.6-0.5-1.3
Rb content in liver2.93.65.9-2.4-2.3-0.90.9-0.90.92.3-2.4-2.42.2-2.32.1-2.10.4
Se content in liver1.51.93.2-1.6-1.6-0.60.6-0.50.51.8-1.7-1.71.6-1.81.6-1.50.5
Sr content in liver1.21.12.8-1.0-0.7-1.71.7-1.71.70.5-0.1-0.10.1-0.3-0.10.1-1.3
Zn content in liver0.40.51.0-1.0-0.8-0.10.1-0.10.10.9-0.9-0.90.8-0.80.8-0.80.4
Bone: minimum diameter0.10.20.4-0.2-0.30.3-0.30.3-0.30.4-0.5-0.50.4-0.30.6-0.50.6
Time in familiar zone, hab. session 10.10.10.20.30.30.5-0.50.5-0.5-0.20.10.1-0.10.2-0.10.10.3
Time in novel zone, hab. session 10.60.60.9-0.8-0.9-0.20.2-0.20.21.0-0.9-0.90.9-0.90.9-0.90.4
Total zone transitions, hab. session 10.00.00.0-0.20.1-0.20.2-0.20.2-0.00.10.1-0.2-0.1-0.20.1-0.1
Total locomotion distance, hab. session 10.20.30.5-0.6-0.50.0-0.00.0-0.00.6-0.6-0.60.6-0.70.6-0.60.4
Locomotion velocity, hab. session 10.00.00.0-0.20.0-0.20.2-0.20.2-0.00.10.1-0.1-0.1-0.10.1-0.2
Time in familiar zone, hab. session 21.41.42.91.71.40.8-0.80.8-0.8-1.51.31.3-1.21.6-1.21.2-0.2
Time in novel zone, hab. session 22.02.04.1-2.0-1.7-1.01.0-1.01.01.8-1.5-1.51.5-1.91.4-1.40.2
Total zone transitions, hab. session 20.40.51.2-1.1-0.8-0.80.8-0.70.80.8-0.6-0.60.6-1.00.5-0.5-0.0
Total locomotion distance, hab. session 20.40.61.2-1.1-0.7-1.11.1-1.11.10.6-0.3-0.30.3-0.80.2-0.3-0.5
Locomotion velocity, hab. session 20.60.81.6-1.3-0.9-1.11.1-1.11.10.9-0.6-0.60.5-1.00.4-0.5-0.4
Novel to familiar place preference ratio0.80.82.2-0.6-0.5-1.51.5-1.51.50.2-0.0-0.00.0-0.2-0.20.2-1.2
Novelty place preference0.80.92.4-0.7-0.5-1.51.5-1.51.50.3-0.0-0.00.0-0.2-0.20.2-1.2
Time in novel zone, NPP test0.80.82.2-0.7-0.5-1.51.5-1.51.50.3-0.0-0.00.1-0.2-0.20.2-1.2
Total zone transitions, NPP test0.40.51.50.40.41.2-1.21.2-1.2-0.1-0.0-0.0-0.0-0.00.2-0.31.2
Total locomotion distance, NPP test0.10.10.3-0.00.10.6-0.60.6-0.60.0-0.0-0.0-0.1-0.10.1-0.20.6
Locomotion velocity, NPP test0.00.10.2-0.2-0.00.3-0.30.3-0.30.2-0.2-0.20.0-0.30.2-0.20.4
Intraocular pressure0.40.61.5-0.3-0.1-1.21.2-1.21.2-0.10.30.3-0.30.1-0.50.5-1.1
Delta distance traveled before/after self-admin0.40.40.70.60.70.2-0.20.2-0.2-0.70.90.9-0.80.7-0.70.7-0.5
Delta ambulatory time before/after self-admin0.60.71.30.81.00.5-0.40.4-0.4-0.91.11.1-1.10.8-0.90.8-0.3
Parametrial fat weight1.63.08.3-1.0-0.8-2.92.9-2.92.90.30.20.20.0-0.2-0.50.6-2.6
Pavlov. Cond. lever latency0.40.51.5-0.5-0.4-1.21.2-1.21.20.2-0.1-0.10.0-0.1-0.20.2-1.0
Pavlov. Cond. magazine entry latency1.31.72.61.51.51.6-1.61.6-1.6-1.31.21.2-1.11.1-0.90.80.8
Pavlov. Cond. change in total contacts0.40.40.9-1.0-0.7-0.70.7-0.70.70.8-0.5-0.50.6-0.90.5-0.5-0.1
Pavlov. Cond. index score1.41.83.11.61.51.8-1.81.8-1.8-1.21.11.1-1.01.1-0.80.80.9
Pavlov. Cond. latency score1.11.52.71.41.31.6-1.61.6-1.6-1.10.90.9-0.90.9-0.60.60.9
Pavlov. Cond. lever contacts0.60.71.50.90.91.2-1.21.2-1.2-0.60.60.6-0.60.5-0.40.30.8
Pavlov. Cond. magazine entry number1.72.13.4-1.7-1.8-1.51.4-1.51.41.6-1.6-1.61.5-1.31.3-1.2-0.4
Pavlov. Cond. intertrial magazine entries1.11.32.5-1.0-1.30.2-0.20.2-0.21.3-1.6-1.61.5-1.11.5-1.50.9
Pavlov. Cond. lever-magazine prob. diff.1.72.13.61.71.71.9-1.91.9-1.9-1.31.21.2-1.11.1-0.80.81.0
Pavlov. Cond. response bias0.81.02.00.91.11.4-1.41.4-1.4-0.80.80.8-0.70.5-0.50.50.9
Pavlov. Cond. lever latency4.15.69.0-2.7-2.9-0.80.8-0.80.82.9-3.0-3.02.9-2.82.9-2.80.9
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.10.2-0.20.2-0.20.20.10.10.1-0.20.0-0.10.4
Pavlov. Cond. change in total contacts0.40.50.90.60.8-0.00.0-0.00.0-0.80.90.9-0.80.9-0.90.9-0.5
Pavlov. Cond. index score1.21.52.51.41.60.6-0.60.6-0.6-1.41.61.6-1.51.4-1.51.4-0.1
Pavlov. Cond. latency score1.11.42.41.31.50.8-0.80.8-0.8-1.41.51.5-1.41.3-1.31.30.0
Pavlov. Cond. lever contacts3.54.77.52.62.70.7-0.70.6-0.6-2.72.72.7-2.72.7-2.62.6-1.0
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.40.2-0.20.2-0.20.3-0.6-0.60.5-0.30.6-0.50.4
Pavlov. Cond. intertrial magazine entries0.00.00.10.20.1-0.10.1-0.10.1-0.20.10.1-0.30.1-0.20.2-0.2
Pavlov. Cond. lever-magazine prob. diff.1.01.22.11.31.40.7-0.70.7-0.7-1.31.41.4-1.31.3-1.21.20.1
Pavlov. Cond. response bias1.82.44.21.71.80.2-0.20.2-0.2-1.82.02.0-1.91.9-2.01.9-0.9
Time in closed arm before self-admin0.70.81.6-0.9-1.1-0.10.1-0.10.11.1-0.9-0.91.3-1.01.1-1.10.8
Time in closed arm after self-admin1.11.22.41.31.01.5-1.51.5-1.5-0.90.80.8-0.60.9-0.50.40.7
Time in open arm before self-admin1.82.03.31.71.81.2-1.21.2-1.2-1.61.51.5-1.71.6-1.41.4-0.2
Time in open arm after self-admin0.60.71.80.10.2-1.21.2-1.21.2-0.50.30.3-0.60.5-0.60.8-1.3
Bone: periosteal estimation0.81.72.8-1.6-1.7-0.90.9-0.90.91.6-1.5-1.51.5-1.41.4-1.30.2
Bone: periosteal perimeter1.32.23.7-1.9-1.8-1.31.3-1.31.31.7-1.6-1.61.5-1.61.4-1.3-0.2
Bone: post-yield work0.20.20.4-0.7-0.6-0.40.4-0.40.40.6-0.5-0.50.6-0.60.5-0.40.1
Progressive ratio test 1 active lever presses0.00.00.20.1-0.0-0.30.3-0.30.3-0.1-0.1-0.1-0.00.2-0.00.2-0.5
Progressive ratio test 1 breakpoint0.10.10.20.40.30.1-0.10.1-0.1-0.30.10.1-0.20.5-0.20.3-0.2
Progressive ratio test 1 inactive lever presses1.41.53.3-1.8-1.4-1.31.3-1.31.31.7-1.1-1.11.1-1.20.9-0.9-0.5
Progressive ratio test 2 active lever presses0.00.00.1-0.0-0.3-0.10.1-0.10.10.1-0.3-0.30.4-0.10.3-0.20.0
Progressive ratio test 2 breakpoint0.00.00.1-0.0-0.2-0.30.3-0.30.3-0.0-0.2-0.20.1-0.00.2-0.1-0.2
Progressive ratio test 2 inactive lever presses0.50.61.6-0.5-0.3-1.31.2-1.31.20.2-0.1-0.10.1-0.0-0.10.3-1.2
Incentive Sensitization - Responses0.10.10.30.00.0-0.40.4-0.40.4-0.20.10.1-0.10.2-0.10.2-0.5
Incentive Sensitization - Breakpoint0.10.10.30.10.1-0.40.3-0.40.4-0.30.20.2-0.20.2-0.20.3-0.5
Sum of active levers in priming session hrs 5-60.40.41.0-1.0-0.7-0.60.6-0.60.60.8-0.6-0.60.6-0.90.4-0.50.3
Progressive ratio0.20.20.50.4-0.10.5-0.60.5-0.6-0.0-0.3-0.30.50.10.5-0.40.7
Food seeking constrained by brief footshock3.44.17.0-2.1-2.4-0.00.0-0.00.02.5-2.6-2.62.3-2.52.6-2.61.6
Seeking ratio, punishment vs. effort0.91.12.5-1.6-1.2-0.60.6-0.60.61.5-1.2-1.20.8-1.51.0-1.10.1
Retroperitoneal fat weight0.10.40.90.50.5-0.30.3-0.30.3-0.60.60.6-0.80.6-0.70.7-0.9
Reaction time number correct0.10.20.3-0.00.2-0.60.6-0.60.6-0.20.50.5-0.40.1-0.50.5-0.6
Reaction time mean minus median2.12.84.41.71.90.1-0.20.1-0.1-2.02.12.1-2.12.1-2.12.1-1.4
Reaction time mean minus median AUC0.91.22.01.31.40.6-0.60.6-0.6-1.21.31.3-1.31.4-1.21.2-0.5
Reaction time num false alarms0.60.81.5-0.7-0.70.5-0.50.5-0.51.0-1.0-1.01.0-1.21.1-1.10.9
Reaction time num false alarms AUC0.91.32.0-0.7-0.80.9-0.90.9-0.91.1-1.2-1.21.2-1.31.4-1.41.4
Reaction time trials correct on left0.10.20.3-0.00.2-0.60.6-0.60.6-0.20.50.5-0.40.1-0.50.5-0.6
Reaction time trials on left0.10.20.30.00.3-0.50.5-0.50.5-0.30.50.5-0.40.2-0.50.5-0.6
Reaction time mean0.91.22.21.31.30.4-0.40.4-0.4-1.41.31.3-1.31.5-1.31.3-0.6
Reaction time mean AUC1.01.42.51.51.40.7-0.70.7-0.7-1.41.31.3-1.31.6-1.21.2-0.3
Median of all reaction times0.40.61.21.00.90.3-0.30.3-0.3-1.00.90.9-0.91.1-0.90.9-0.4
Reaction time omissions0.91.31.91.41.41.1-1.11.1-1.1-1.11.11.1-1.11.3-0.90.90.4
Reaction time false alarm rate1.21.72.8-0.7-0.91.1-1.11.1-1.11.2-1.4-1.41.4-1.41.6-1.61.7
Reaction time premature initiation rate1.62.25.11.51.42.3-2.32.3-2.3-0.90.80.8-0.70.9-0.40.31.4
Reaction time premature initiations0.81.22.41.11.21.5-1.51.5-1.5-0.70.80.8-0.70.8-0.50.50.9
Std. dev. reaction times1.82.54.41.71.80.2-0.20.2-0.2-1.91.91.9-2.02.1-1.91.9-1.3
Reaction time trials completed0.10.20.30.00.3-0.50.5-0.50.5-0.30.50.5-0.40.2-0.50.5-0.6
Reaction time trials AUC0.10.20.3-0.10.1-0.60.6-0.60.6-0.10.30.3-0.30.0-0.40.4-0.5
Run reversals in cocaine runway, females0.60.60.90.91.00.5-0.50.5-0.5-0.80.90.9-1.00.9-0.80.8-0.5
Run reversals in cocaine runway, males0.30.30.6-0.6-0.8-0.40.4-0.40.40.5-0.7-0.70.5-0.70.6-0.6-0.1
Latency to leave start box in cocaine runway0.30.30.5-0.2-0.40.5-0.50.5-0.50.6-0.5-0.50.6-0.50.7-0.70.6
Latency to leave start box in cocaine runway, F0.91.01.6-1.0-1.10.2-0.20.2-0.21.2-1.2-1.21.2-1.21.2-1.31.3
Latency to leave start box in cocaine runway, M0.50.51.21.10.80.6-0.60.6-0.6-0.80.60.6-0.80.9-0.60.6-0.7
Std. dev. time between licks in bursts0.10.10.30.10.3-0.30.3-0.30.3-0.30.50.5-0.40.3-0.50.4-0.5
Total sessions with >9 infusions0.30.40.8-0.0-0.40.6-0.60.6-0.60.2-0.6-0.60.5-0.50.8-0.80.9
Short access day 1 total inactive lever presses3.13.55.8-2.1-2.4-0.90.9-0.90.92.3-2.3-2.32.2-2.22.2-2.20.5
Short access day 10 total inactive lever presses0.20.20.40.40.60.4-0.40.4-0.4-0.40.70.7-0.70.3-0.50.40.1
Short access day 1 total infusions0.50.51.10.3-0.21.0-1.11.1-1.1-0.0-0.6-0.60.4-0.20.7-0.71.0
Short access day 10 total infusions0.40.41.00.3-0.20.8-0.80.8-0.80.1-0.6-0.60.5-0.00.7-0.61.0
Short access total infusions0.80.92.30.3-0.31.2-1.21.2-1.20.1-0.8-0.80.7-0.31.0-0.91.5
Short access day 1 locomotion1.61.84.90.90.32.1-2.12.1-2.1-0.4-0.3-0.30.3-0.00.7-0.82.2
Short access day 10 total locomotion0.50.51.20.90.21.1-1.11.1-1.1-0.7-0.2-0.20.00.30.3-0.31.1
Short access total locomotion2.22.35.31.80.92.3-2.32.3-2.3-1.40.30.3-0.50.80.1-0.11.9
One hour access (0.3 mA shock)0.10.10.20.2-0.20.1-0.10.1-0.1-0.0-0.4-0.40.3-0.10.4-0.30.3
Compulsive drug intake1.61.62.31.51.51.4-1.41.4-1.4-1.31.31.3-1.31.2-1.00.90.5
One hour access (shock baseline)0.60.71.0-0.6-1.0-0.90.9-0.90.90.6-1.0-1.01.0-0.60.8-0.6-0.3
Social response proportion1.81.95.1-0.9-0.4-2.22.3-2.32.30.10.50.5-0.2-0.2-0.70.7-1.9
Social responses1.51.95.2-1.3-0.7-2.32.3-2.32.30.50.00.00.0-0.6-0.30.3-1.9
Social time0.50.71.5-0.10.2-1.11.1-1.11.1-0.40.70.7-0.70.3-0.90.8-1.2
Soleus weight1.13.36.0-1.9-2.2-0.30.3-0.30.32.2-2.3-2.32.5-1.92.3-2.21.0
Bone: stiffness0.00.00.0-0.00.0-0.10.1-0.10.1-0.00.00.0-0.00.1-0.10.10.0
Tibialis anterior weight0.72.33.7-1.9-1.8-1.71.7-1.71.71.6-1.4-1.41.4-1.61.1-1.1-0.5
Time to tail flick, vehicle, before self-admin0.10.10.20.10.00.4-0.40.4-0.40.1-0.1-0.10.2-0.00.1-0.20.5
Time to tail flick, vehicle, after self-admin0.10.20.8-0.1-0.10.4-0.40.4-0.40.2-0.2-0.20.4-0.30.3-0.40.9
Time to tail flick, test, before self-admin0.30.30.50.70.60.6-0.60.6-0.6-0.60.50.5-0.70.6-0.30.4-0.1
Time to tail flick, test, after self-admin2.82.84.6-2.1-2.1-0.70.7-0.70.72.1-2.1-2.11.9-2.21.8-1.90.6
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.0-0.10.0-0.00.0-0.00.0-0.2-0.20.3-0.00.2-0.10.3
Delta time to tail flick, test, before/after SA1.31.12.0-1.4-1.2-1.01.0-1.01.01.2-1.1-1.11.0-1.30.7-0.8-0.0
Tibia length0.51.43.3-0.1-0.61.3-1.31.3-1.30.8-1.3-1.31.2-0.61.4-1.31.8
Ambulatory time before self-admin2.32.44.5-1.0-1.70.5-0.50.5-0.51.3-2.1-2.12.1-1.72.0-2.11.7
Ambulatory time after self-admin0.80.91.5-0.8-1.00.3-0.30.3-0.31.1-1.2-1.21.1-1.01.2-1.21.0
Bone: tissue strength0.10.10.3-0.1-0.0-0.50.4-0.50.4-0.10.10.10.00.2-0.20.2-0.5
Total heroin consumption0.10.10.3-0.2-0.4-0.20.1-0.10.10.2-0.5-0.50.5-0.20.3-0.30.3
Bone: trabecular number0.30.51.3-0.1-0.30.8-0.80.8-0.80.5-0.6-0.60.5-0.50.7-0.71.2
Bone: trabecular spacing0.60.81.6-1.1-0.9-1.31.3-1.31.30.7-0.5-0.50.6-0.60.3-0.3-0.8
Bone: trabecular thickness0.91.12.90.90.71.7-1.71.7-1.7-0.30.20.2-0.20.30.2-0.21.5
Bone: trabecular tissue density1.01.42.70.91.1-0.50.5-0.60.6-1.41.41.4-1.41.2-1.51.5-1.6
Water consumed over 24 hours0.91.13.0-1.1-0.6-1.71.7-1.71.70.40.10.10.1-0.5-0.20.2-1.3
Number of responses in last shaping day0.30.31.00.1-0.20.6-0.60.6-0.60.2-0.4-0.40.5-0.30.5-0.51.0