Emid1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC alternative TSS NM_001401620.1 0.05 0.04 9.6e-03 0.02 0.01 0.01 0.01 5.3e-02 7.5e-02 1.6e-01 1.4e-01
2 IC alternative TSS XM_008770369.4 0.05 0.04 9.5e-03 0.02 0.01 0 0.01 5.2e-02 7.2e-02 3.2e-01 1.3e-01
3 IC alternative TSS XM_008770369.4 0.05 0.04 9.1e-03 0.02 0.01 -0 0 5.0e-02 1.1e-01 4.2e-01 3.0e-01
4 PL gene expression Emid1 0.33 0.14 0.0e+00 0.24 0.28 0.29 0.29 7.5e-26 4.0e-31 1.4e-31 2.1e-31
5 Adipose mRNA stability Emid1 0.09 0.08 1.5e-03 0.01 0.02 0.02 0.02 1.1e-02 1.1e-03 2.5e-03 4.4e-03
6 Brain isoform ratio NM_001401622.1 0.02 0.02 9.8e-03 0 0.01 -0 -0 2.7e-01 6.6e-02 6.5e-01 8.1e-01
7 Adipose gene expression Emid1 0.09 0.06 4.9e-08 0.04 0.06 0.05 0.06 5.7e-05 2.5e-07 1.4e-06 1.8e-07
8 IL gene expression Emid1 0.39 0.19 2.5e-04 0.15 0.16 0.16 0.15 2.1e-04 1.4e-04 1.1e-04 1.8e-04
9 OFC mRNA stability Emid1 0.45 0.2 1.5e-03 0.11 0.07 0.05 0.07 1.6e-03 8.5e-03 3.1e-02 8.0e-03
10 Brain alternative TSS XM_008770369.4 0.07 0.05 7.8e-05 0.01 0.03 0.03 0.02 5.5e-02 4.2e-04 1.1e-03 3.5e-03
11 IC gene expression Emid1 0.42 0.15 2.0e-12 0.28 0.26 0.27 0.29 2.6e-12 1.5e-11 1.1e-11 1.3e-12
12 NAcc mRNA stability Emid1 0.06 0.07 3.1e-03 0.01 0.01 0.01 0.01 2.1e-03 3.2e-02 3.1e-02 7.8e-03
13 Brain alternative TSS NM_001401620.1 0.07 0.05 7.6e-05 0.01 0.03 0.03 0.02 5.6e-02 4.3e-04 1.3e-03 3.4e-03
14 pVTA gene expression Emid1 0.12 0.07 9.3e-06 0.07 0.07 0.06 0.07 1.7e-06 2.9e-06 1.5e-05 4.1e-06
15 Brain alternative TSS XM_008770369.4 0.07 0.05 8.3e-05 0.01 0.03 0.03 0.02 5.1e-02 4.5e-04 8.5e-04 2.7e-03
16 BLA gene expression Emid1 0.4 0.17 4.0e-12 0.2 0.22 0.21 0.21 5.6e-11 6.1e-12 3.8e-11 1.9e-11
17 Brain alternative TSS NM_001401620.1 0.07 0.05 8.7e-05 0.01 0.03 0.03 0.02 5.3e-02 5.0e-04 8.0e-04 3.1e-03
18 NAcc gene expression Emid1 0.28 0.1 0.0e+00 0.18 0.2 0.19 0.19 1.4e-26 9.2e-29 1.2e-28 1.2e-28
19 Brain gene expression Emid1 0.3 0.13 0.0e+00 0.24 0.18 0.24 0.22 9.9e-23 8.6e-17 3.8e-22 5.3e-20
20 IC mRNA stability Emid1 0.19 0.11 8.2e-03 0.02 0.05 0.01 0.04 4.3e-02 3.5e-03 7.3e-02 7.6e-03
21 Brain mRNA stability Emid1 0.12 0.08 2.5e-04 0.06 0.02 0.04 0.05 7.7e-06 2.2e-03 3.0e-04 2.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.10.31.3-0.60.60.5-0.0-0.20.2-0.20.20.1-0.7-0.30.30.70.3-0.8-0.30.8-0.40.4-0.71.1
Area under the delay curve1.82.74.82.2-2.2-2.21.91.9-2.0-1.61.61.51.6-1.61.6-1.61.61.6-1.6-1.6-1.21.5-0.2-0.3
BMI with tail0.00.20.60.3-0.3-0.3-0.1-0.0-0.10.3-0.3-0.20.60.2-0.2-0.6-0.20.60.1-0.60.4-0.30.6-0.8
BMI without tail0.21.32.31.0-1.0-1.11.31.5-1.2-1.31.31.30.4-1.51.5-0.41.50.3-1.2-0.3-1.41.1-0.90.6
Body weight1.04.46.92.5-2.5-2.52.52.6-2.5-2.32.22.21.7-2.22.2-1.72.21.7-2.3-1.7-1.82.0-0.7-0.2
Weight adjusted by age0.30.91.90.8-0.8-0.71.01.3-1.0-1.11.21.40.1-1.21.3-0.11.20.0-1.1-0.0-1.30.5-1.10.8
Bone surface0.10.30.80.3-0.3-0.40.60.3-0.7-0.70.60.50.2-0.60.6-0.20.60.2-0.8-0.2-0.40.9-0.30.5
Bone volume0.10.30.80.2-0.2-0.20.60.3-0.6-0.70.60.50.0-0.60.6-0.00.60.0-0.90.0-0.50.9-0.40.7
Breakpoint value in progressive ratio session0.30.50.80.9-0.9-0.80.80.8-0.8-0.70.60.60.7-0.70.7-0.70.80.7-0.6-0.7-0.50.7-0.1-0.1
Number of licking bursts0.92.64.01.8-1.8-1.82.01.9-2.0-1.91.81.71.2-1.71.7-1.21.71.2-1.9-1.2-1.41.8-0.70.0
Context. condit. distance diff. score2.83.45.5-2.32.32.3-2.2-2.12.21.9-1.8-1.8-1.81.8-1.81.7-1.8-1.71.81.71.3-1.80.30.3
Locomotion velocity, session 11.61.84.60.3-0.3-0.3-0.9-1.00.51.3-1.4-1.51.31.5-1.5-1.3-1.51.41.2-1.41.9-1.12.2-2.0
Locomotion distance, session 10.50.61.6-1.11.11.0-0.4-0.40.70.1-0.1-0.1-1.30.0-0.01.3-0.1-1.30.21.3-0.3-0.0-0.81.2
Locomotion velocity, session 21.31.54.20.1-0.1-0.1-0.9-1.20.41.2-1.4-1.51.11.4-1.4-1.1-1.51.21.0-1.21.9-1.02.0-1.8
Locomotion distance, session 21.82.54.4-1.71.71.6-1.9-2.11.81.8-1.8-1.8-0.91.8-1.80.9-1.9-0.81.60.81.7-1.61.0-0.3
Locomotion velocity, session 31.82.14.3-2.12.12.1-1.5-1.61.71.1-1.1-1.1-1.81.1-1.11.8-1.1-1.81.01.80.6-0.9-0.30.8
Locomotion distance, session 30.10.10.5-0.10.10.10.2-0.2-0.3-0.40.20.1-0.1-0.10.10.10.1-0.1-0.70.10.00.7-0.10.4
Stereotopy head waving bouts, day 30.60.71.5-1.21.21.2-0.9-0.91.00.7-0.6-0.6-1.10.6-0.61.1-0.5-1.10.61.10.2-0.6-0.30.6
Stereotopy head waving duration, day 31.51.93.0-1.61.61.6-1.7-1.51.71.6-1.5-1.4-1.21.4-1.41.2-1.4-1.11.71.11.0-1.60.30.0
Locomotion velocity, session 70.10.10.20.4-0.4-0.40.20.1-0.4-0.20.20.20.4-0.10.1-0.40.00.4-0.4-0.40.10.20.2-0.2
Locomotion distance, session 70.50.61.1-0.60.60.6-1.0-1.00.71.0-1.0-1.0-0.11.0-1.00.1-1.0-0.10.60.11.0-0.90.8-0.6
Stereotopy head waving bouts, day 70.00.00.1-0.10.10.10.10.20.1-0.10.10.1-0.20.0-0.00.20.1-0.20.10.2-0.20.0-0.20.1
Stereotopy head waving duration, day 70.10.20.5-0.20.20.20.30.3-0.1-0.40.40.4-0.4-0.30.30.40.4-0.5-0.30.5-0.60.5-0.70.7
Locomotion velocity, session 82.12.54.4-1.31.31.3-1.9-2.11.61.9-2.0-2.0-0.32.0-2.00.3-2.1-0.31.70.22.0-1.71.5-0.8
Locomotion distance, session 86.08.612.9-3.63.63.6-3.6-3.53.63.2-3.1-3.0-2.63.0-3.02.6-3.0-2.53.12.52.3-3.00.80.3
Degree of sensitization distance2.12.24.5-1.11.11.1-1.9-1.61.62.0-1.9-1.8-0.41.8-1.80.4-1.8-0.41.90.41.6-2.11.2-1.0
Degree of sensitization stereotypy0.10.20.40.4-0.4-0.40.50.6-0.4-0.50.50.50.2-0.30.3-0.20.40.2-0.3-0.2-0.50.4-0.30.0
Conditioned locomotion0.91.02.7-1.41.41.4-0.6-0.60.90.2-0.2-0.0-1.60.3-0.31.7-0.2-1.70.31.7-0.2-0.1-1.01.2
Cocaine response after cond. corrected1.21.82.71.6-1.6-1.61.61.7-1.6-1.51.41.41.1-1.41.4-1.11.41.0-1.3-1.0-1.11.3-0.5-0.1
Cocaine response after cond. not corrected1.82.64.31.7-1.7-1.72.02.1-1.8-1.91.91.90.8-2.02.0-0.81.90.7-1.7-0.7-1.71.7-1.10.4
Cocaine response before conditioning0.20.30.8-0.70.70.7-0.3-0.20.50.1-0.1-0.0-0.9-0.10.10.90.1-0.90.20.9-0.3-0.2-0.60.7
Saline control response0.70.91.8-0.90.90.9-1.1-1.31.01.0-1.1-1.1-0.41.3-1.30.4-1.3-0.30.90.31.2-0.90.8-0.7
Bone: connectivity density0.20.20.9-0.70.70.6-0.2-0.40.40.1-0.0-0.1-0.8-0.00.00.8-0.0-0.80.00.8-0.20.1-0.50.9
Bone: cortical apparent density0.50.71.10.9-0.9-1.01.01.0-1.0-0.90.90.80.7-1.01.0-0.71.00.6-0.9-0.6-0.71.0-0.30.1
Bone: cortical area1.93.24.81.9-1.9-1.92.22.1-2.1-2.12.02.01.2-2.02.0-1.22.01.1-2.1-1.1-1.62.0-0.90.4
Bone: cortical porosity0.10.10.20.1-0.1-0.10.40.4-0.3-0.40.40.4-0.1-0.40.40.10.4-0.1-0.40.1-0.50.4-0.40.4
Bone: cortical porosity0.10.10.3-0.40.40.4-0.1-0.00.30.1-0.00.0-0.6-0.00.00.60.0-0.60.10.6-0.2-0.1-0.40.5
Bone: cortical thickness2.03.35.71.3-1.3-1.42.22.1-2.0-2.42.32.30.4-2.32.3-0.42.20.3-2.4-0.3-2.12.3-1.61.2
Bone: cortical thickness0.81.02.7-1.21.21.1-0.2-0.20.6-0.20.30.3-1.6-0.30.31.60.3-1.6-0.11.6-0.80.1-1.41.5
Bone: cortical tissue density0.50.71.11.0-1.0-1.11.01.0-1.0-0.90.90.80.8-0.90.9-0.80.90.7-0.9-0.7-0.60.9-0.20.0
Condit. Reinf. active minus inactive responses0.91.02.70.9-0.9-0.9-0.1-0.3-0.50.4-0.5-0.61.60.6-0.6-1.6-0.61.60.0-1.61.1-0.31.6-1.6
Condit. Reinf. active-inactive response ratio3.03.28.00.3-0.3-0.3-1.4-1.40.71.9-2.0-2.01.62.0-2.0-1.6-2.01.71.6-1.72.5-1.92.8-2.7
Condit. Reinf. active responses0.30.41.10.5-0.5-0.6-0.0-0.3-0.40.2-0.3-0.41.00.4-0.4-1.0-0.41.0-0.2-1.00.8-0.11.1-1.1
Condit. Reinf. inactive responses0.60.81.80.0-0.0-0.10.90.6-0.7-1.21.11.1-0.5-1.11.10.51.1-0.5-1.40.5-1.11.3-1.21.1
Incentive salience index mean0.60.72.01.0-1.0-1.10.40.2-0.8-0.20.1-0.01.4-0.00.0-1.4-0.01.4-0.5-1.40.50.31.0-1.0
Condit. Reinf. lever presses0.20.20.70.3-0.3-0.40.50.4-0.6-0.60.60.50.2-0.60.6-0.20.60.2-0.8-0.2-0.40.7-0.30.4
Condit. Reinf. active minus inactive responses0.30.50.9-0.90.90.9-0.9-0.90.80.8-0.9-0.9-0.50.8-0.80.5-0.8-0.50.80.50.7-0.60.40.2
Condit. Reinf. active-inactive response ratio0.10.10.2-0.10.10.1-0.4-0.40.20.4-0.5-0.50.10.4-0.4-0.1-0.40.10.3-0.10.5-0.30.5-0.3
Condit. Reinf. active responses0.60.91.4-1.01.01.0-1.1-1.21.11.1-1.2-1.2-0.51.1-1.10.5-1.1-0.41.10.41.0-0.80.60.1
Condit. Reinf. inactive responses0.71.01.7-1.01.01.0-1.2-1.21.11.2-1.2-1.2-0.41.3-1.30.4-1.3-0.41.30.41.1-1.00.7-0.2
Condit. Reinf. lever presses0.40.51.1-1.01.01.0-0.7-0.90.80.6-0.6-0.6-0.80.6-0.60.8-0.6-0.80.60.80.4-0.4-0.00.7
Condit. Reinf. lever reinforcers received0.50.71.2-0.90.90.9-1.0-1.10.90.9-1.0-1.1-0.41.0-1.00.4-1.0-0.40.90.40.9-0.70.60.2
Conditioned reinforcement - actives0.10.30.70.8-0.8-0.90.40.7-0.6-0.40.50.60.5-0.80.8-0.50.80.4-0.4-0.4-0.5-0.1-0.2-0.1
Conditioned reinforcement - inactives0.30.71.31.2-1.2-1.10.90.9-1.0-0.80.70.61.0-0.60.6-1.00.61.0-0.7-1.0-0.30.80.2-0.7
Conditioned locomotion0.71.11.81.3-1.3-1.21.01.4-1.2-0.91.11.30.6-1.31.3-0.61.30.6-1.2-0.5-1.10.1-0.70.3
Patch foraging indifference point 0 sec0.82.43.61.8-1.8-1.81.91.9-1.8-1.71.71.61.1-1.61.6-1.11.71.1-1.7-1.1-1.41.5-0.60.0
Patch foraging indifference point AUC0.00.10.40.3-0.3-0.20.10.0-0.20.0-0.1-0.00.40.1-0.1-0.4-0.20.4-0.1-0.40.2-0.10.3-0.6
Delay disc. indifference point, 0s delay1.21.42.31.2-1.2-1.21.41.5-1.3-1.31.31.30.6-1.51.5-0.61.50.6-1.2-0.6-1.31.2-0.80.5
Delay disc. indifference point, 16s delay1.21.73.71.9-1.9-1.91.01.1-1.3-0.70.60.61.9-0.70.7-1.90.71.9-0.6-1.9-0.10.50.8-1.2
Delay disc. indifference point, 2s delay2.42.64.31.2-1.2-1.21.92.0-1.6-2.02.02.00.2-2.02.1-0.22.10.1-1.8-0.1-2.01.9-1.61.3
Delay disc. indifference point, 24s delay0.50.81.71.3-1.3-1.30.80.7-1.0-0.60.50.31.3-0.50.5-1.30.51.3-0.6-1.3-0.00.60.6-0.7
Delay disc. indifference point, 4s delay2.93.14.91.9-1.9-1.92.12.2-2.0-2.12.01.91.0-2.02.0-1.02.00.9-1.9-0.9-1.81.9-1.10.6
Delay disc. indifference point, 8s delay0.50.81.71.3-1.3-1.30.90.9-1.0-0.70.70.61.1-0.70.7-1.10.61.1-0.7-1.1-0.40.60.2-0.5
Indifference point function ln k0.10.31.1-0.40.40.30.30.1-0.1-0.50.40.4-0.6-0.50.50.60.5-0.6-0.60.6-0.60.6-0.81.1
Indifference point function log k0.10.31.1-0.40.40.30.30.1-0.1-0.50.40.4-0.6-0.50.50.60.5-0.6-0.60.6-0.60.6-0.81.1
Patch foraging total patch changes 0 sec0.72.23.31.8-1.8-1.81.81.8-1.8-1.61.61.51.2-1.51.5-1.21.51.2-1.7-1.2-1.21.4-0.4-0.2
Patch foraging total patch changes 12 sec0.91.22.01.3-1.3-1.31.31.4-1.3-1.21.21.30.8-1.11.1-0.81.10.7-1.2-0.7-1.00.9-0.5-0.3
Patch foraging total patch changes 18 sec0.71.53.91.8-1.8-1.70.80.8-1.2-0.40.30.32.0-0.20.2-2.00.22.0-0.5-2.00.40.21.2-1.7
Patch foraging total patch changes 24 sec0.41.52.7-0.90.90.9-1.5-1.31.41.5-1.4-1.3-0.41.5-1.50.4-1.5-0.41.60.41.3-1.61.0-0.9
Patch foraging total patch changes 6 sec1.01.62.71.5-1.5-1.51.61.4-1.7-1.41.31.21.3-1.01.0-1.31.11.2-1.6-1.2-0.81.4-0.1-0.3
Patch foraging time to switch 0 sec0.10.30.6-0.60.60.6-0.6-0.40.70.4-0.4-0.3-0.70.3-0.30.7-0.3-0.70.70.70.1-0.5-0.20.4
Patch foraging water rate 0 sec0.41.52.71.6-1.6-1.61.21.0-1.5-0.90.80.71.6-0.80.8-1.60.71.6-1.2-1.6-0.20.90.5-1.4
Patch foraging water rate 12 sec0.00.00.10.0-0.0-0.10.0-0.1-0.2-0.00.0-0.00.20.0-0.1-0.2-0.10.2-0.3-0.20.10.10.2-0.2
Patch foraging water rate 18 sec0.51.13.4-0.30.30.20.60.9-0.1-0.91.01.1-1.2-1.11.11.21.1-1.3-0.71.3-1.60.7-1.81.3
Patch foraging water rate 24 sec0.30.41.40.3-0.3-0.3-0.4-0.30.10.6-0.6-0.60.70.5-0.5-0.7-0.60.70.4-0.70.8-0.71.0-1.2
Patch foraging water rate 6 sec0.30.50.80.6-0.6-0.70.80.8-0.8-0.90.90.90.2-0.90.9-0.20.80.2-0.9-0.2-0.80.7-0.60.2
Seeking ratio, delayed vs. immediate footshock0.00.00.40.2-0.2-0.0-0.20.10.30.3-0.2-0.2-0.00.0-0.0-0.00.00.00.6-0.00.0-0.30.1-0.1
Distance traveled before self-admin0.61.22.50.3-0.3-0.41.11.2-0.8-1.31.31.5-0.5-1.21.20.51.3-0.5-1.20.5-1.61.2-1.51.5
Distance traveled after self-admin0.81.43.5-0.10.10.10.91.1-0.5-1.21.31.3-1.0-1.31.31.01.3-1.0-1.11.0-1.71.1-1.91.8
Extensor digitorum longus weight2.610.215.93.5-3.5-3.54.03.7-3.9-3.83.63.52.3-3.43.4-2.33.42.2-3.8-2.2-2.83.6-1.40.5
Bone: elastic displacement0.40.51.4-0.80.80.6-0.20.00.5-0.10.20.2-1.2-0.20.21.20.2-1.20.11.2-0.6-0.0-1.01.0
Bone: elastic work0.91.23.00.1-0.1-0.10.91.2-0.5-1.21.31.3-0.8-1.41.40.81.4-0.8-0.90.9-1.71.0-1.71.5
Bone: endosteal estimation0.00.10.30.5-0.5-0.40.40.5-0.3-0.30.30.30.2-0.40.4-0.20.40.2-0.1-0.2-0.40.2-0.2-0.0
Bone: endosteal perimeter0.30.81.71.3-1.3-1.31.01.1-1.0-0.80.80.81.0-0.70.7-1.00.71.0-0.7-1.0-0.50.70.1-0.5
Epididymis fat weight0.21.22.50.8-0.8-0.71.41.1-1.3-1.51.41.40.3-1.21.2-0.31.20.3-1.6-0.3-1.11.5-0.90.5
Delta time in closed arm before/after self-admin6.25.89.2-3.03.03.0-2.8-2.43.02.6-2.3-2.0-2.52.2-2.32.5-2.2-2.42.62.41.3-2.70.10.7
Delta time in open arm before/after self-admin4.45.29.53.1-3.1-3.12.52.5-2.7-2.22.02.12.5-2.12.1-2.52.02.5-2.1-2.5-1.21.90.1-1.1
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.20.2-0.2-0.00.20.1-0.10.0-0.30.1-0.10.3-0.0-0.30.20.3-0.1-0.1-0.20.1
Delay discount exponential model param1.92.64.6-2.12.12.1-1.8-1.91.91.6-1.5-1.4-1.61.6-1.61.6-1.6-1.51.61.51.1-1.50.30.3
Extinction: sum of active levers before priming0.10.20.60.3-0.3-0.2-0.1-0.3-0.10.3-0.3-0.30.60.4-0.4-0.6-0.40.60.2-0.60.7-0.20.8-0.6
Active lever presses in extinction session 60.20.20.7-0.10.10.10.10.30.1-0.30.40.5-0.6-0.40.30.60.4-0.6-0.10.6-0.60.1-0.80.8
Bone: final force0.20.30.50.5-0.5-0.50.60.6-0.6-0.60.60.60.3-0.70.7-0.30.70.3-0.7-0.3-0.50.6-0.30.3
Bone: final moment0.30.50.90.7-0.7-0.70.90.8-0.8-0.90.90.90.3-1.01.0-0.30.90.3-1.0-0.3-0.80.8-0.50.5
Food consumed during 24 hour testing period0.81.54.11.6-1.6-1.60.80.5-1.3-0.40.20.12.0-0.30.3-2.00.22.0-0.7-2.00.40.61.3-1.4
Glucose13.321.058.65.9-5.9-5.92.31.8-4.0-0.70.1-0.17.60.1-0.1-7.6-0.17.6-1.4-7.72.40.75.4-6.6
Heart weight0.60.92.90.3-0.3-0.4-0.5-0.80.10.8-0.9-1.11.10.9-0.9-1.1-0.91.20.4-1.21.4-0.51.7-1.4
Delay discount hyperbolic model param2.12.74.5-2.12.12.1-1.9-2.02.01.8-1.7-1.6-1.41.7-1.71.4-1.7-1.41.71.41.3-1.60.50.1
Intermittent access intake day 1-15 change0.10.72.01.0-1.0-1.00.50.3-0.9-0.20.20.21.4-0.20.2-1.40.21.4-0.5-1.40.5-0.01.0-1.1
Intermittent access intake escalation0.10.61.60.9-0.9-0.80.40.2-0.8-0.20.10.11.3-0.10.1-1.20.11.3-0.5-1.30.50.10.9-1.0
Intermittent access intake escalation 20.10.10.40.5-0.5-0.30.20.1-0.4-0.10.00.00.60.0-0.0-0.60.00.6-0.4-0.60.3-0.00.5-0.5
Intermitt. access day 1 inactive lever presses0.00.30.7-0.50.50.4-0.7-0.50.50.8-0.8-0.90.00.7-0.7-0.0-0.70.00.8-0.00.6-0.70.6-0.7
Intermitt. access day 15 inactive lever presses0.31.74.61.5-1.5-1.40.90.3-1.1-0.60.30.12.10.0-0.0-2.1-0.12.1-0.5-2.10.81.01.6-2.0
Intermitt. access escalation Index0.31.03.00.1-0.1-0.0-0.6-1.00.30.9-0.9-0.91.01.1-1.1-1.0-1.11.00.6-1.01.5-0.81.6-1.7
Intermittent access day 1 total infusions0.30.91.90.9-0.9-0.80.91.3-0.7-1.11.11.2-0.1-1.21.30.11.3-0.2-0.80.2-1.40.7-1.20.8
Intermittent access day 15 total infusions0.81.93.51.9-1.9-1.71.51.6-1.7-1.41.41.51.3-1.51.5-1.31.51.2-1.5-1.2-0.91.0-0.2-0.3
Intermittent access terminal intake (last 3 days)0.71.32.21.4-1.4-1.31.21.5-1.3-1.21.31.40.8-1.41.4-0.81.40.8-1.2-0.8-1.00.7-0.40.0
Intermittent access total infusions1.31.52.51.5-1.5-1.41.41.6-1.3-1.31.41.50.7-1.51.5-0.71.50.6-1.3-0.6-1.21.0-0.70.3
Intermittent access day 1 locomotion0.20.31.10.1-0.10.00.10.6-0.0-0.30.50.6-0.7-0.60.60.70.6-0.7-0.20.7-0.9-0.3-1.01.0
Intermittent access day 15 total locomotion0.31.12.31.4-1.4-1.51.11.3-1.2-0.91.01.11.0-1.11.2-1.01.21.0-0.9-1.0-0.80.6-0.2-0.2
Intermittent access total locomotion1.01.22.11.4-1.4-1.31.21.3-1.2-1.11.21.20.8-1.21.2-0.81.20.8-1.1-0.8-0.90.8-0.40.1
Intermittent access standard deviation0.10.41.0-0.60.60.8-0.6-0.30.60.5-0.3-0.2-1.00.2-0.21.0-0.1-1.00.21.0-0.2-0.9-0.60.8
Left kidney weight0.11.02.60.3-0.3-0.41.11.4-0.6-1.21.21.2-0.5-1.21.20.51.2-0.5-0.90.5-1.61.0-1.51.2
Right kidney weight0.42.67.1-0.20.20.21.21.4-0.5-1.61.71.7-1.6-1.81.81.61.8-1.7-1.41.7-2.41.5-2.72.4
Cocaine induced anxiety0.82.13.51.8-1.8-1.71.61.4-1.9-1.51.31.21.6-1.51.5-1.61.41.5-1.7-1.5-0.71.50.1-0.3
Post-drug Anxiety1.21.42.41.5-1.5-1.51.20.8-1.5-1.10.90.81.5-0.90.9-1.50.81.5-1.3-1.5-0.11.20.5-0.7
Baseline Anxiety0.20.30.8-0.30.30.3-0.5-0.80.50.6-0.6-0.60.10.9-0.9-0.1-0.80.10.8-0.10.8-0.50.6-0.6
Tail length1.89.614.73.0-3.0-3.03.83.8-3.6-3.83.73.51.5-3.73.7-1.53.61.3-3.7-1.3-3.33.7-2.11.3
Length with tail2.19.314.63.1-3.1-3.13.83.7-3.6-3.83.73.61.6-3.53.5-1.63.41.5-3.7-1.5-3.13.5-1.90.9
Length without tail0.10.51.00.7-0.7-0.71.00.8-1.0-0.90.90.80.5-0.70.7-0.50.70.5-1.0-0.5-0.60.9-0.30.1
Times rat made contact with spout1.51.74.70.3-0.3-0.3-0.9-1.10.31.3-1.4-1.51.41.4-1.4-1.4-1.51.40.9-1.41.9-1.12.2-1.9
Lifetime Intake1.41.72.91.5-1.5-1.41.41.7-1.3-1.41.51.60.5-1.71.7-0.51.70.4-1.3-0.4-1.51.0-1.00.6
Liver weight, left0.50.92.6-0.90.90.80.10.20.4-0.40.50.4-1.4-0.50.51.40.5-1.5-0.21.5-1.00.4-1.51.6
Liver weight, right0.61.12.9-1.41.41.4-0.7-0.51.10.4-0.3-0.2-1.70.1-0.11.7-0.1-1.70.61.7-0.4-0.4-1.11.3
Locomotor activity0.61.02.51.4-1.4-1.30.50.8-0.8-0.10.10.11.6-0.10.1-1.60.21.6-0.1-1.60.2-0.00.9-1.6
Locomotor testing distance0.51.12.30.8-0.8-0.61.31.5-1.0-1.31.41.40.0-1.31.3-0.01.3-0.0-1.10.0-1.51.1-1.20.5
Locomotor testing rearing0.62.13.21.7-1.7-1.61.81.7-1.8-1.61.51.41.4-1.41.4-1.41.41.3-1.5-1.3-1.11.5-0.3-0.3
Locomotion in novel chamber1.72.34.8-2.02.02.0-1.4-1.21.71.1-0.9-0.7-2.20.9-0.92.2-1.1-2.21.12.20.1-1.2-0.91.2
Locomotion in novel chamber post-restriction1.33.96.6-1.91.91.8-2.2-2.52.32.1-2.3-2.5-0.62.5-2.50.6-2.6-0.52.50.52.4-1.41.7-0.8
Fecal boli incidents, locomotor time 10.10.20.4-0.40.40.4-0.6-0.60.40.6-0.6-0.7-0.00.5-0.50.0-0.40.00.5-0.00.5-0.50.4-0.4
Change in fecal boli incidents, locomotor task0.60.61.80.5-0.5-0.5-0.3-0.5-0.00.5-0.7-0.81.00.7-0.7-1.0-0.71.10.4-1.11.1-0.41.3-1.1
Time >=10cm from walls, locomotor time 10.10.10.30.0-0.0-0.0-0.1-0.20.10.2-0.2-0.20.30.3-0.4-0.3-0.40.30.3-0.30.3-0.30.4-0.5
Bouts of movement, locomotor time 10.50.71.90.8-0.8-0.80.1-0.1-0.40.2-0.3-0.31.40.4-0.3-1.4-0.41.40.1-1.40.8-0.21.3-1.3
Total resting periods, locomotor time 10.70.92.60.4-0.4-0.4-0.4-0.60.10.7-0.8-0.81.20.8-0.8-1.2-0.91.20.7-1.21.3-0.71.6-1.4
Rest time, locomotor task time 10.20.20.90.1-0.1-0.1-0.3-0.50.00.4-0.5-0.60.60.4-0.3-0.6-0.40.70.2-0.70.8-0.20.9-0.5
Distance moved, locomotor task time 10.20.71.70.6-0.6-0.61.01.2-0.7-1.01.11.2-0.2-0.90.90.20.8-0.2-0.90.2-1.30.8-1.20.5
Vertical activity count, locomotor time 10.00.30.80.5-0.5-0.50.60.9-0.5-0.60.70.7-0.1-0.60.60.10.5-0.1-0.50.1-0.90.3-0.70.2
Time >=10cm from walls, locomotor time 20.10.20.80.0-0.0-0.0-0.4-0.10.40.6-0.5-0.40.10.3-0.3-0.1-0.30.20.9-0.20.3-0.90.3-0.6
Bouts of movement, locomotor time 20.00.00.00.1-0.1-0.1-0.1-0.10.10.0-0.0-0.1-0.1-0.10.10.10.2-0.10.00.10.1-0.1-0.00.1
Total resting periods, locomotor time 20.00.00.10.2-0.2-0.2-0.1-0.20.00.1-0.1-0.20.10.0-0.0-0.10.00.10.0-0.10.3-0.10.3-0.1
Rest time, locomotor task time 20.10.20.6-0.40.40.4-0.5-0.70.40.5-0.6-0.60.00.6-0.6-0.0-0.50.00.4-0.00.7-0.30.6-0.3
Distance moved, locomotor task time 20.00.00.1-0.10.10.1-0.20.10.20.2-0.1-0.1-0.2-0.00.00.2-0.2-0.20.20.2-0.1-0.4-0.1-0.1
Vertical activity count, locomotor time 20.00.10.20.1-0.1-0.10.10.4-0.1-0.10.20.2-0.1-0.40.40.10.3-0.1-0.10.1-0.5-0.1-0.40.1
Light reinforcement 10.20.91.80.3-0.3-0.21.00.9-0.7-1.21.21.2-0.4-1.11.10.51.2-0.5-1.10.5-1.21.1-1.31.4
Light reinforcement 20.41.02.10.6-0.6-0.51.01.2-0.6-1.21.31.4-0.4-1.21.20.41.2-0.5-0.90.5-1.40.8-1.41.1
Bone: marrow area0.00.10.20.4-0.4-0.30.20.4-0.2-0.20.20.20.1-0.30.3-0.10.30.1-0.0-0.1-0.30.1-0.1-0.0
Bone: maximum diameter2.44.89.33.0-3.0-3.12.32.1-2.7-1.81.61.42.9-1.51.5-2.91.52.9-2.0-2.9-0.61.80.8-1.4
Bone: maximum force0.30.51.10.4-0.4-0.40.80.8-0.7-0.90.90.9-0.0-1.01.00.01.0-0.1-0.90.1-0.90.8-0.80.8
Bone: maximum moment0.50.91.70.5-0.5-0.51.11.0-0.9-1.21.21.2-0.0-1.31.30.01.2-0.1-1.20.1-1.21.1-1.00.9
Mean time between licks in bursts0.21.23.11.0-1.0-1.0-0.1-0.2-0.40.5-0.6-0.71.70.6-0.6-1.7-0.61.70.3-1.71.2-0.41.7-1.7
Mean num. licks in bursts1.43.76.2-1.41.41.4-2.3-2.41.92.5-2.5-2.5-0.22.4-2.40.2-2.4-0.12.20.12.5-2.32.0-1.3
Cd content in liver0.40.41.20.8-0.8-0.70.40.3-0.6-0.10.10.01.1-0.10.1-1.10.01.1-0.2-1.10.30.20.7-0.9
Co content in liver0.40.50.90.2-0.2-0.30.90.7-0.6-0.90.90.9-0.1-0.90.90.10.9-0.1-0.90.2-0.91.0-0.80.7
Cu content in liver0.10.20.50.4-0.4-0.40.20.1-0.3-0.10.00.00.70.1-0.1-0.7-0.20.7-0.2-0.70.30.10.5-0.7
Fe content in liver2.22.74.3-1.61.61.5-2.1-2.01.92.0-2.0-2.0-0.81.9-1.90.8-2.1-0.81.90.81.7-1.91.1-0.3
K content in liver3.53.46.21.0-1.0-1.02.22.0-1.7-2.42.42.3-0.1-2.42.40.12.5-0.2-2.10.2-2.42.4-2.11.4
Mg content in liver0.50.61.20.4-0.4-0.41.00.7-0.7-1.11.11.0-0.0-0.90.80.00.9-0.1-0.90.1-0.91.1-0.80.5
Mn content in liver0.91.02.00.1-0.1-0.11.00.8-0.7-1.31.31.3-0.6-1.11.10.61.2-0.7-1.20.7-1.31.3-1.41.3
Na content in liver1.51.73.11.8-1.8-1.71.41.2-1.5-1.11.00.91.6-0.90.9-1.61.01.6-1.1-1.6-0.41.10.4-0.6
Rb content in liver2.02.44.11.5-1.5-1.52.01.8-1.7-2.01.92.00.7-1.81.8-0.71.70.7-1.8-0.7-1.61.8-1.10.6
Se content in liver1.92.24.00.7-0.7-0.81.71.4-1.4-2.02.01.9-0.1-1.91.90.21.9-0.2-1.90.2-1.82.0-1.61.4
Sr content in liver2.52.24.22.0-2.0-2.01.51.4-1.7-1.11.00.92.0-0.90.9-2.00.92.0-1.2-2.0-0.31.10.6-1.1
Zn content in liver0.50.61.10.3-0.3-0.20.90.8-0.7-1.01.01.0-0.1-0.90.90.10.9-0.1-0.90.1-1.01.0-0.90.7
Bone: minimum diameter0.10.10.4-0.10.10.20.10.20.0-0.20.30.3-0.4-0.40.40.40.4-0.4-0.10.4-0.50.1-0.60.7
Time in familiar zone, hab. session 10.10.10.2-0.40.40.4-0.4-0.40.30.2-0.2-0.1-0.50.2-0.20.5-0.2-0.50.10.50.1-0.2-0.20.3
Time in novel zone, hab. session 10.60.61.00.7-0.7-0.71.01.0-0.8-1.01.00.90.3-1.01.0-0.31.00.3-0.8-0.3-0.90.9-0.70.3
Total zone transitions, hab. session 10.00.00.10.0-0.0-0.0-0.0-0.2-0.10.0-0.1-0.20.30.2-0.2-0.3-0.20.3-0.1-0.30.30.10.3-0.2
Total locomotion distance, hab. session 10.20.20.50.3-0.3-0.30.60.4-0.5-0.60.60.60.0-0.60.60.00.6-0.0-0.70.0-0.50.7-0.50.4
Locomotion velocity, hab. session 10.00.00.00.1-0.1-0.1-0.0-0.1-0.10.0-0.1-0.10.20.1-0.1-0.2-0.10.2-0.0-0.20.2-0.00.2-0.1
Time in familiar zone, hab. session 21.31.52.7-1.21.21.2-1.6-1.21.61.5-1.4-1.3-0.91.3-1.30.9-1.3-0.91.60.90.9-1.70.4-0.2
Time in novel zone, hab. session 21.92.13.81.4-1.4-1.41.81.4-1.9-1.81.61.51.1-1.61.6-1.11.61.0-1.9-1.0-1.12.0-0.50.2
Total zone transitions, hab. session 20.40.50.90.8-0.8-0.80.90.6-0.9-0.80.70.60.8-0.70.7-0.80.60.7-0.9-0.7-0.30.90.0-0.0
Total locomotion distance, hab. session 20.40.51.10.9-0.9-0.90.70.4-0.9-0.60.50.41.0-0.40.4-1.00.31.0-0.8-1.00.10.70.5-0.4
Locomotion velocity, hab. session 20.50.71.31.1-1.1-1.10.90.7-1.1-0.80.70.61.1-0.70.7-1.10.61.0-1.0-1.0-0.20.90.3-0.3
Novel to familiar place preference ratio0.60.82.31.2-1.2-1.20.50.5-0.8-0.10.10.01.5-0.00.0-1.50.21.5-0.2-1.50.40.11.0-1.3
Novelty place preference0.70.92.51.2-1.2-1.20.50.5-0.9-0.20.10.01.6-0.00.0-1.60.21.6-0.3-1.60.40.21.0-1.3
Time in novel zone, NPP test0.70.82.31.2-1.2-1.20.50.5-0.8-0.20.10.11.5-0.00.0-1.50.21.5-0.3-1.50.30.21.0-1.2
Total zone transitions, NPP test0.40.61.7-1.01.01.0-0.4-0.50.60.00.00.0-1.2-0.10.11.2-0.0-1.20.01.2-0.30.1-0.81.3
Total locomotion distance, NPP test0.10.10.5-0.50.50.5-0.1-0.30.2-0.10.10.0-0.6-0.10.20.60.1-0.6-0.20.6-0.10.2-0.40.7
Locomotion velocity, NPP test0.10.10.4-0.20.20.20.1-0.00.0-0.20.20.2-0.4-0.30.30.40.2-0.4-0.30.4-0.20.3-0.40.6
Intraocular pressure0.40.61.70.7-0.7-0.7-0.0-0.1-0.30.4-0.5-0.51.20.4-0.4-1.2-0.41.20.2-1.30.8-0.31.3-1.3
Delta distance traveled before/after self-admin0.50.50.8-0.90.90.9-0.9-0.70.90.8-0.7-0.8-0.70.6-0.60.7-0.7-0.70.80.70.4-0.80.0-0.1
Delta ambulatory time before/after self-admin0.40.71.2-1.11.11.1-1.0-0.90.90.9-0.8-0.9-0.80.8-0.80.8-0.8-0.80.70.80.5-0.80.10.0
Parametrial fat weight2.45.716.02.7-2.7-2.80.50.3-1.40.4-0.6-0.73.90.7-0.7-3.9-0.63.90.2-3.92.0-0.33.4-4.0
Pavlov. Cond. lever latency0.30.30.80.9-0.9-0.90.40.5-0.5-0.20.20.20.9-0.10.1-0.90.10.9-0.0-0.90.00.00.4-0.7
Pavlov. Cond. magazine entry latency1.82.34.0-2.02.02.0-1.9-1.81.81.6-1.4-1.4-1.61.3-1.31.6-1.3-1.51.31.51.0-1.40.20.6
Pavlov. Cond. change in total contacts0.50.51.00.8-0.8-0.80.80.5-1.0-0.70.60.50.8-0.60.6-0.80.60.8-1.0-0.8-0.20.90.2-0.1
Pavlov. Cond. index score1.62.04.2-2.02.02.0-1.6-1.61.61.2-1.1-1.1-1.71.0-1.01.7-1.0-1.71.01.70.7-1.0-0.21.0
Pavlov. Cond. latency score1.21.63.3-1.81.81.8-1.4-1.41.41.0-0.9-0.9-1.60.8-0.81.6-0.8-1.60.81.60.5-0.8-0.30.9
Pavlov. Cond. lever contacts0.70.82.0-1.41.41.4-0.8-0.90.90.5-0.5-0.5-1.30.4-0.41.3-0.4-1.30.31.30.2-0.2-0.50.9
Pavlov. Cond. magazine entry number2.12.74.72.2-2.2-2.22.02.1-1.8-1.71.61.61.6-1.51.5-1.61.51.5-1.3-1.5-1.31.4-0.4-0.5
Pavlov. Cond. intertrial magazine entries1.11.32.50.8-0.8-0.81.31.5-0.9-1.41.51.6-0.1-1.41.40.11.4-0.2-1.10.2-1.61.1-1.40.8
Pavlov. Cond. lever-magazine prob. diff.1.92.44.9-2.22.22.2-1.7-1.71.71.2-1.1-1.1-2.01.0-1.02.0-1.0-1.91.01.90.6-1.0-0.31.2
Pavlov. Cond. response bias0.91.22.8-1.71.71.6-1.1-1.31.10.7-0.7-0.7-1.50.6-0.61.5-0.6-1.50.41.50.4-0.4-0.41.0
Pavlov. Cond. lever latency4.05.68.82.2-2.2-2.22.92.9-2.6-3.03.03.00.8-2.82.8-0.82.80.7-2.8-0.7-2.72.7-1.91.0
Pavlov. Cond. magazine entry latency0.10.10.3-0.50.50.5-0.3-0.50.30.2-0.3-0.3-0.30.2-0.20.3-0.3-0.30.10.30.3-0.10.10.2
Pavlov. Cond. change in total contacts0.20.40.8-0.40.40.4-0.8-0.80.70.9-0.9-0.90.00.8-0.8-0.0-0.90.10.9-0.10.9-0.80.7-0.3
Pavlov. Cond. index score1.11.72.8-1.31.31.3-1.6-1.71.41.6-1.6-1.6-0.61.5-1.50.5-1.5-0.51.50.51.5-1.41.0-0.3
Pavlov. Cond. latency score1.11.83.1-1.51.51.5-1.6-1.81.51.6-1.6-1.6-0.81.5-1.50.8-1.5-0.81.50.81.4-1.40.8-0.1
Pavlov. Cond. lever contacts3.75.58.5-2.32.32.3-2.9-2.92.72.9-2.9-2.9-1.02.8-2.81.0-2.8-0.92.80.92.6-2.71.7-0.8
Pavlov. Cond. magazine entry number0.20.30.60.3-0.3-0.30.50.7-0.4-0.60.70.7-0.2-0.70.70.20.7-0.2-0.40.2-0.80.4-0.70.4
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.1-0.10.1-0.0-0.0-0.1-0.0-0.00.10.1-0.1-0.1-0.10.1-0.0-0.10.10.20.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.11.72.9-1.41.41.4-1.6-1.71.51.5-1.5-1.6-0.71.5-1.50.7-1.5-0.71.40.71.4-1.40.8-0.1
Pavlov. Cond. response bias2.12.94.9-1.51.51.5-2.1-2.11.82.2-2.2-2.2-0.52.0-2.00.5-2.0-0.42.10.42.0-1.91.5-0.8
Time in closed arm before self-admin0.50.81.80.5-0.5-0.40.91.1-0.8-1.01.00.9-0.2-1.21.20.21.2-0.2-1.00.3-1.31.0-1.10.9
Time in closed arm after self-admin1.61.93.7-1.91.91.9-1.4-1.11.61.2-1.0-0.9-1.81.0-1.01.8-1.0-1.81.11.80.2-1.1-0.60.8
Time in open arm before self-admin0.40.50.9-0.90.90.9-0.8-0.90.90.7-0.6-0.7-0.70.7-0.60.7-0.6-0.70.70.70.6-0.60.10.3
Time in open arm after self-admin0.70.82.21.3-1.3-1.30.40.4-0.7-0.20.10.11.5-0.30.3-1.50.21.5-0.0-1.50.40.11.0-1.1
Bone: periosteal estimation0.61.42.31.3-1.3-1.31.51.5-1.4-1.41.41.30.8-1.41.4-0.81.40.7-1.3-0.7-1.21.2-0.60.2
Bone: periosteal perimeter1.01.93.11.7-1.7-1.81.71.7-1.7-1.51.41.41.3-1.41.4-1.31.31.2-1.4-1.2-1.11.3-0.3-0.2
Bone: post-yield work0.00.10.20.2-0.2-0.20.30.2-0.3-0.30.30.30.2-0.40.4-0.20.30.2-0.4-0.2-0.20.3-0.10.1
Progressive ratio test 1 active lever presses0.40.81.41.0-1.0-0.90.91.2-0.9-0.91.01.10.4-1.21.2-0.41.10.4-0.8-0.4-1.00.6-0.60.3
Progressive ratio test 1 breakpoint0.40.71.20.9-0.9-0.90.91.1-0.9-0.90.91.00.5-1.11.1-0.51.00.4-0.8-0.4-0.80.5-0.50.3
Progressive ratio test 1 inactive lever presses1.54.06.12.5-2.5-2.42.42.2-2.4-2.22.01.82.0-1.92.0-2.01.92.0-2.0-1.9-1.22.3-0.2-0.4
Progressive ratio test 2 active lever presses0.60.91.61.2-1.2-1.31.01.1-1.1-0.91.01.00.8-1.21.2-0.81.10.8-0.9-0.8-0.70.7-0.2-0.1
Progressive ratio test 2 breakpoint0.50.71.31.1-1.1-1.20.90.9-0.9-0.80.80.80.8-1.01.0-0.80.90.8-0.8-0.8-0.50.6-0.1-0.2
Progressive ratio test 2 inactive lever presses0.41.32.71.6-1.6-1.61.01.0-1.2-0.80.80.71.5-0.90.9-1.50.81.5-0.7-1.5-0.20.80.5-1.0
Incentive Sensitization - Responses0.10.20.60.6-0.6-0.80.40.3-0.5-0.20.20.20.8-0.30.3-0.80.30.8-0.2-0.80.10.30.4-0.6
Incentive Sensitization - Breakpoint0.10.20.50.5-0.5-0.70.30.3-0.4-0.10.10.10.7-0.20.2-0.70.20.7-0.1-0.70.10.20.4-0.6
Sum of active levers in priming session hrs 5-60.30.21.00.1-0.1-0.00.60.3-0.5-0.60.50.50.1-0.40.4-0.10.40.1-0.7-0.1-0.41.0-0.30.9
Progressive ratio0.10.20.5-0.10.10.4-0.10.30.30.10.10.1-0.6-0.30.40.60.4-0.60.20.6-0.6-0.3-0.70.7
Food seeking constrained by brief footshock3.84.77.71.7-1.7-1.82.72.7-2.3-2.82.72.70.5-2.52.5-0.52.60.4-2.6-0.3-2.62.7-2.01.7
Seeking ratio, punishment vs. effort0.51.03.60.7-0.7-1.01.40.9-1.2-1.51.31.10.5-0.90.9-0.51.00.5-1.5-0.5-0.81.9-0.50.4
Retroperitoneal fat weight0.52.36.81.5-1.5-1.60.20.0-0.80.4-0.5-0.62.50.8-0.8-2.5-0.72.50.2-2.51.4-0.42.3-2.6
Reaction time number correct0.00.10.50.0-0.0-0.0-0.2-0.40.00.3-0.4-0.40.50.4-0.4-0.5-0.40.50.2-0.50.6-0.10.7-0.4
Reaction time mean minus median0.42.84.7-1.21.21.3-2.0-2.01.72.1-2.1-2.2-0.12.0-2.00.1-2.0-0.02.10.02.1-2.01.7-1.5
Reaction time mean minus median AUC0.21.42.1-1.21.21.2-1.4-1.41.31.5-1.4-1.4-0.61.3-1.30.5-1.3-0.51.50.51.2-1.40.8-0.8
Reaction time num false alarms0.50.81.60.0-0.0-0.10.80.6-0.6-1.11.11.0-0.6-1.11.10.61.1-0.6-1.30.6-1.21.2-1.20.9
Reaction time num false alarms AUC0.51.22.8-0.10.10.10.80.7-0.6-1.21.31.2-1.0-1.31.31.01.3-1.0-1.41.0-1.51.4-1.71.4
Reaction time trials correct on left0.00.10.50.0-0.0-0.0-0.2-0.40.00.3-0.4-0.40.50.4-0.4-0.5-0.40.50.2-0.50.6-0.10.7-0.4
Reaction time trials on left0.00.20.5-0.00.00.0-0.2-0.50.10.3-0.4-0.40.40.4-0.4-0.4-0.40.40.2-0.40.7-0.20.7-0.4
Reaction time mean0.51.12.1-0.90.90.9-1.3-1.11.21.4-1.3-1.3-0.31.2-1.20.3-1.2-0.31.50.31.1-1.30.8-0.8
Reaction time mean AUC0.51.32.4-1.11.11.1-1.4-1.21.41.4-1.4-1.4-0.71.3-1.30.7-1.2-0.61.50.61.0-1.40.6-0.6
Median of all reaction times0.30.51.2-0.60.60.6-0.9-0.70.91.0-0.9-0.9-0.30.8-0.80.3-0.8-0.31.10.30.7-1.00.5-0.5
Reaction time omissions1.01.62.5-1.61.61.5-1.5-1.41.61.4-1.3-1.3-1.21.2-1.21.2-1.3-1.11.51.10.9-1.30.20.1
Reaction time false alarm rate1.11.53.6-0.10.10.11.00.9-0.6-1.31.41.3-1.0-1.41.41.11.4-1.1-1.41.1-1.71.4-1.91.5
Reaction time premature initiation rate1.62.45.3-2.32.32.2-1.4-1.31.71.0-0.8-0.8-2.30.8-0.82.3-0.8-2.31.02.30.1-0.9-1.01.4
Reaction time premature initiations0.51.53.3-1.81.81.8-1.1-1.31.30.9-0.8-0.8-1.60.8-0.81.6-0.8-1.60.81.60.4-0.7-0.41.0
Std. dev. reaction times0.82.64.4-1.21.21.2-1.9-1.81.72.1-2.0-2.1-0.21.9-1.90.2-1.9-0.12.10.11.9-2.01.5-1.5
Reaction time trials completed0.00.20.5-0.00.00.0-0.2-0.50.10.3-0.4-0.40.40.4-0.4-0.4-0.40.40.2-0.40.7-0.20.7-0.4
Reaction time trials AUC0.00.10.30.1-0.1-0.1-0.1-0.3-0.10.1-0.2-0.30.50.2-0.2-0.5-0.20.50.0-0.50.50.00.6-0.3
Run reversals in cocaine runway, females0.80.91.5-1.11.11.1-1.1-1.21.11.0-1.1-1.2-0.51.2-1.20.5-0.9-0.51.00.51.0-0.60.6-0.1
Run reversals in cocaine runway, males0.40.40.70.7-0.7-0.70.70.8-0.8-0.60.70.70.4-0.80.8-0.40.60.3-0.8-0.3-0.70.3-0.40.1
Latency to leave start box in cocaine runway0.30.40.90.1-0.1-0.00.70.7-0.4-0.80.80.8-0.4-0.70.70.40.6-0.4-0.70.4-0.90.9-0.90.8
Latency to leave start box in cocaine runway, F1.31.62.70.8-0.8-0.81.61.5-1.3-1.61.61.60.0-1.51.50.01.5-0.1-1.60.1-1.61.6-1.41.5
Latency to leave start box in cocaine runway, M0.40.40.9-0.70.70.7-0.7-0.60.90.7-0.6-0.6-0.50.6-0.60.5-0.8-0.51.00.50.5-0.60.2-0.6
Std. dev. time between licks in bursts0.10.20.4-0.10.10.1-0.4-0.50.20.5-0.5-0.50.20.5-0.5-0.2-0.50.30.3-0.30.6-0.40.6-0.6
Total sessions with >9 infusions0.70.93.0-0.60.60.7-0.30.30.4-0.10.30.5-1.5-0.60.61.50.5-1.5-0.11.5-1.1-0.5-1.61.7
Short access day 1 total inactive lever presses2.34.57.32.4-2.4-2.42.62.7-2.5-2.42.42.41.3-2.52.5-1.32.41.2-2.4-1.2-2.12.2-1.20.4
Short access day 10 total inactive lever presses0.00.10.20.3-0.3-0.30.30.3-0.4-0.30.20.10.2-0.10.1-0.20.10.2-0.4-0.2-0.20.4-0.0-0.1
Short access day 1 total infusions0.40.82.9-0.50.50.5-0.10.30.3-0.10.40.5-1.4-0.70.71.40.6-1.4-0.21.4-1.1-0.3-1.61.7
Short access day 10 total infusions0.30.51.6-0.10.10.20.20.60.1-0.40.50.6-0.9-0.80.80.90.7-0.9-0.10.9-1.10.0-1.21.2
Short access total infusions0.91.22.80.5-0.5-0.40.81.3-0.6-1.01.21.4-0.6-1.51.50.71.4-0.7-0.90.7-1.70.5-1.71.6
Short access day 1 locomotion1.01.76.6-0.90.91.0-0.20.20.4-0.20.50.7-2.0-0.80.82.00.7-2.0-0.42.0-1.5-0.3-2.12.6
Short access day 10 total locomotion0.31.13.7-0.90.90.9-0.50.20.60.30.10.4-1.6-0.30.31.60.3-1.70.11.7-1.1-1.2-1.61.9
Short access total locomotion0.91.44.6-1.01.01.1-0.60.10.70.20.10.4-1.9-0.40.41.90.3-1.90.11.9-1.1-1.0-1.82.1
One hour access (0.3 mA shock)1.31.52.51.6-1.6-1.61.31.5-1.4-1.31.31.30.9-1.41.4-0.91.40.9-1.2-0.9-1.10.9-0.50.1
Compulsive drug intake0.91.32.1-1.51.51.4-1.3-1.11.41.2-1.1-1.1-1.21.2-1.21.2-1.1-1.21.21.20.6-1.1-0.00.4
One hour access (shock baseline)0.61.73.21.8-1.8-1.71.41.5-1.5-1.21.31.41.2-1.51.5-1.21.51.1-1.2-1.1-0.90.7-0.3-0.2
Social response proportion1.11.44.01.3-1.3-1.20.30.2-0.80.2-0.3-0.52.00.3-0.3-2.0-0.32.0-0.1-2.00.9-0.01.7-1.7
Social responses1.31.74.81.6-1.6-1.60.60.4-1.1-0.20.0-0.22.20.1-0.1-2.2-0.12.2-0.4-2.20.70.31.6-1.8
Social time0.40.61.60.2-0.2-0.3-0.4-0.50.10.7-0.7-0.80.90.9-0.9-0.9-1.00.90.5-0.91.0-0.61.3-1.2
Soleus weight1.33.86.61.6-1.6-1.52.32.6-1.8-2.42.42.50.2-2.52.5-0.22.50.1-2.0-0.1-2.52.0-2.01.4
Bone: stiffness0.00.00.1-0.20.20.2-0.2-0.20.20.2-0.2-0.2-0.10.1-0.10.1-0.1-0.10.20.10.1-0.20.00.1
Tibialis anterior weight0.82.74.52.1-2.1-2.01.91.9-2.1-1.71.61.61.6-1.61.5-1.61.61.6-1.8-1.6-1.11.6-0.2-0.2
Time to tail flick, vehicle, before self-admin0.10.10.20.0-0.0-0.00.20.2-0.2-0.30.30.3-0.2-0.30.30.20.3-0.2-0.30.2-0.40.4-0.40.4
Time to tail flick, vehicle, after self-admin0.10.20.4-0.50.50.5-0.6-0.50.60.5-0.5-0.4-0.50.5-0.50.5-0.4-0.40.40.40.3-0.30.10.1
Time to tail flick, test, before self-admin0.20.20.7-0.00.0-0.00.30.5-0.1-0.40.50.5-0.5-0.50.50.50.4-0.5-0.30.5-0.80.2-0.80.5
Time to tail flick, test, after self-admin2.52.64.41.6-1.6-1.72.11.9-1.9-2.01.92.10.9-1.71.6-0.91.70.9-2.0-0.9-1.61.9-0.9-0.0
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.20.20.2-0.6-0.40.50.6-0.5-0.5-0.10.5-0.50.1-0.4-0.10.70.10.4-0.70.3-0.1
Delta time to tail flick, test, before/after SA0.50.71.51.0-1.0-1.00.80.5-0.9-0.60.40.51.2-0.30.3-1.20.41.2-0.7-1.20.20.70.7-0.9
Tibia length0.51.54.3-0.40.40.40.61.00.1-1.01.11.3-1.5-1.21.21.51.1-1.5-0.41.5-1.70.7-2.12.1
Ambulatory time before self-admin0.82.34.30.8-0.8-0.81.71.8-1.3-1.91.92.1-0.3-1.81.80.31.9-0.3-1.70.3-2.11.7-1.91.7
Ambulatory time after self-admin0.60.92.4-0.00.00.00.81.0-0.5-1.01.11.2-0.8-1.01.00.81.0-0.8-0.90.8-1.50.9-1.61.3
Bone: tissue strength0.00.00.10.3-0.3-0.30.10.2-0.10.1-0.1-0.10.30.0-0.0-0.4-0.00.40.2-0.40.1-0.20.2-0.3
Total heroin consumption0.00.00.1-0.00.00.1-0.1-0.00.1-0.10.00.1-0.2-0.00.00.20.1-0.20.00.2-0.10.1-0.10.3
Bone: trabecular number0.20.41.4-0.30.30.20.40.3-0.1-0.60.60.6-0.7-0.70.70.70.6-0.7-0.50.7-0.80.6-1.01.2
Bone: trabecular spacing0.60.91.81.4-1.4-1.30.90.9-1.1-0.70.60.61.3-0.60.6-1.30.61.3-0.8-1.3-0.20.60.4-0.8
Bone: trabecular thickness0.81.12.8-1.51.51.5-0.8-0.81.10.4-0.4-0.3-1.70.4-0.41.7-0.3-1.70.51.7-0.2-0.4-0.91.3
Bone: trabecular tissue density0.81.42.7-0.40.40.4-1.2-1.30.91.4-1.5-1.50.41.5-1.5-0.4-1.50.51.2-0.51.6-1.31.6-1.6
Water consumed over 24 hours0.51.02.91.2-1.2-1.20.50.2-1.0-0.1-0.0-0.21.7-0.10.1-1.7-0.01.7-0.5-1.70.60.21.2-1.3
Number of responses in last shaping day0.10.20.3-0.60.60.5-0.5-0.40.50.5-0.4-0.4-0.50.3-0.30.5-0.3-0.50.30.50.2-0.6-0.10.4