Hub : Genes

Elp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Elp3 0.05 0.02 1.4e-06 0.04 0.03 0.04 0.04 2.7e-07 2.8e-05 4.7e-07 4.6e-07
2 pVTA intron excision ratio chr15_43945178_43945869 0.12 0.06 1.6e-06 0.06 0.06 0.06 0.06 2.3e-05 1.6e-05 1.1e-05 2.2e-05
3 Brain gene expression Elp3 0.08 0.04 7.4e-07 0.07 0.07 0.07 0.07 3.1e-07 5.0e-07 6.8e-07 4.5e-07
4 pVTA intron excision ratio chr15_43931353_43945097 0.11 0.06 8.6e-07 0.06 0.07 0.06 0.06 1.3e-05 5.3e-06 1.8e-05 1.5e-05
5 PL mRNA stability Elp3 0.07 0.04 2.3e-07 0.06 0.06 0.05 0.06 6.8e-07 4.7e-07 2.1e-06 1.2e-06
6 Brain mRNA stability Elp3 0.14 0.06 3.7e-12 0.13 0.14 0.13 0.14 9.3e-12 1.2e-12 1.7e-12 8.5e-13
7 Liver mRNA stability Elp3 0.04 0.03 2.0e-03 0.01 0.01 0.01 0.01 6.8e-02 8.3e-03 1.3e-02 4.2e-02
8 Adipose mRNA stability Elp3 0.05 0.03 5.7e-04 0.01 0.02 0.02 0.02 9.6e-03 1.6e-03 2.9e-03 5.9e-03
9 Adipose gene expression Elp3 0.08 0.04 1.7e-09 0.06 0.08 0.07 0.09 3.9e-07 2.1e-09 5.0e-08 1.1e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.31.50.20.40.3-0.40.00.10.90.21.2
Area under the delay curve0.50.62.21.10.80.8-0.30.50.3-0.3-0.2-1.5
BMI with tail0.20.50.8-0.8-0.8-0.90.8-0.4-0.7-0.9-0.3-0.8
BMI without tail0.72.33.4-1.7-1.8-1.61.7-1.4-1.4-1.6-1.1-0.8
Body weight0.20.91.81.01.00.9-0.71.31.00.51.2-0.9
Weight adjusted by age2.64.06.12.11.92.0-2.12.32.51.62.2-0.4
Bone surface0.50.91.81.01.11.0-1.10.70.71.40.61.0
Bone volume0.30.61.20.81.00.9-0.90.40.51.10.20.8
Breakpoint value in progressive ratio session0.10.10.30.40.20.2-0.00.1-0.1-0.1-0.2-0.5
Number of licking bursts0.50.81.1-1.0-0.9-1.11.0-0.8-1.0-0.9-0.6-0.2
Context. condit. distance diff. score8.29.912.6-3.6-3.5-3.53.3-3.4-3.5-2.9-2.9-0.1
Locomotion velocity, session 10.40.50.90.80.90.8-0.80.60.40.70.30.1
Locomotion distance, session 12.43.15.02.12.22.0-2.01.51.61.91.00.6
Locomotion velocity, session 21.21.42.71.61.61.5-1.41.01.01.20.50.3
Locomotion distance, session 23.44.87.62.62.82.6-2.51.91.92.41.30.9
Locomotion velocity, session 30.40.41.3-0.6-0.8-0.50.8-0.2-0.3-0.9-0.1-1.1
Locomotion distance, session 30.60.60.9-0.8-1.0-0.70.9-0.6-0.7-1.0-0.5-0.8
Stereotopy head waving bouts, day 30.50.61.50.60.60.5-0.70.91.00.81.20.3
Stereotopy head waving duration, day 30.50.61.10.80.70.7-0.71.01.00.41.0-0.8
Locomotion velocity, session 79.310.214.1-3.8-3.6-3.73.5-3.4-3.5-2.8-2.60.4
Locomotion distance, session 75.67.19.8-3.1-2.9-2.82.8-3.1-3.1-2.0-2.51.0
Stereotopy head waving bouts, day 71.11.21.91.21.11.1-1.01.41.30.71.2-0.7
Stereotopy head waving duration, day 71.01.22.11.00.80.9-0.81.41.40.41.4-1.2
Locomotion velocity, session 80.70.81.2-0.8-0.8-0.80.9-0.9-1.0-1.0-1.1-0.7
Locomotion distance, session 80.60.81.6-0.9-0.7-0.80.8-1.2-1.3-0.6-1.20.3
Degree of sensitization distance4.24.46.6-2.3-2.0-2.21.9-2.6-2.5-1.1-2.11.7
Degree of sensitization stereotypy0.40.41.20.70.60.6-0.40.70.6-0.00.4-1.1
Conditioned locomotion1.01.11.8-1.3-1.3-1.01.1-1.3-1.1-0.9-1.00.1
Cocaine response after cond. corrected3.44.15.0-2.1-2.1-2.12.2-2.1-2.2-2.2-2.1-0.8
Cocaine response after cond. not corrected2.32.74.1-1.6-1.6-1.71.8-1.7-2.0-1.7-1.8-0.5
Cocaine response before conditioning1.92.22.91.61.71.5-1.61.51.31.71.41.0
Saline control response1.82.43.11.71.61.7-1.71.61.71.61.50.6
Bone: connectivity density0.60.95.8-0.5-0.2-0.4-0.1-0.2-0.11.00.82.4
Bone: cortical apparent density1.21.62.3-1.4-1.4-1.41.5-1.1-1.2-1.5-0.9-0.8
Bone: cortical area0.40.71.41.21.11.0-0.80.60.50.3-0.1-1.1
Bone: cortical porosity1.01.11.91.41.31.2-1.11.21.10.70.8-0.4
Bone: cortical porosity1.81.93.01.71.61.5-1.51.61.51.01.1-0.5
Bone: cortical thickness0.20.31.80.60.40.4-0.10.20.1-0.4-0.4-1.3
Bone: cortical thickness2.02.34.9-1.0-1.2-1.01.5-1.6-1.6-1.9-2.2-1.3
Bone: cortical tissue density1.41.92.7-1.5-1.6-1.51.6-1.2-1.3-1.6-1.0-0.8
Condit. Reinf. active minus inactive responses0.91.01.31.11.11.0-1.01.11.10.91.0-0.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.0-0.1-0.30.10.10.0-0.10.2-0.3
Condit. Reinf. active responses1.82.23.11.71.81.5-1.61.51.51.51.30.4
Condit. Reinf. inactive responses2.83.44.61.92.11.9-2.01.71.72.11.61.3
Incentive salience index mean2.22.73.81.91.91.8-1.71.81.91.41.6-0.2
Condit. Reinf. lever presses2.63.75.42.32.32.2-2.02.02.01.71.60.1
Condit. Reinf. active minus inactive responses0.10.10.30.30.40.4-0.50.10.20.50.10.4
Condit. Reinf. active-inactive response ratio0.10.20.3-0.4-0.5-0.40.4-0.4-0.3-0.4-0.4-0.5
Condit. Reinf. active responses0.10.20.40.40.50.5-0.60.10.20.6-0.00.6
Condit. Reinf. inactive responses0.30.42.10.30.60.4-0.6-0.00.00.9-0.01.5
Condit. Reinf. lever presses1.21.72.21.51.41.4-1.51.41.41.41.20.4
Condit. Reinf. lever reinforcers received0.10.20.40.50.50.5-0.60.20.30.60.10.4
Conditioned reinforcement - actives0.91.52.2-1.4-1.1-1.41.1-1.5-1.5-0.6-1.30.7
Conditioned reinforcement - inactives0.40.64.5-0.5-0.3-0.40.2-0.3-0.10.70.52.1
Conditioned locomotion1.92.53.9-1.5-1.3-1.61.7-1.7-1.9-1.5-2.0-0.5
Patch foraging indifference point 0 sec4.88.911.53.33.33.1-3.32.82.83.42.61.8
Patch foraging indifference point AUC2.84.15.9-1.9-2.0-1.62.0-1.9-1.9-2.3-2.4-2.0
Delay disc. indifference point, 0s delay2.12.33.71.91.81.9-1.51.21.41.61.01.1
Delay disc. indifference point, 16s delay0.40.41.80.1-0.10.10.4-0.4-0.4-0.9-0.9-1.3
Delay disc. indifference point, 2s delay2.42.76.62.62.02.0-1.61.41.51.30.8-0.3
Delay disc. indifference point, 24s delay0.60.71.80.0-0.1-0.10.7-0.7-0.7-1.2-1.3-1.3
Delay disc. indifference point, 4s delay0.60.62.31.20.60.9-0.20.60.7-0.40.1-1.5
Delay disc. indifference point, 8s delay0.30.32.20.30.00.20.00.3-0.1-0.6-0.1-1.5
Indifference point function ln k1.83.13.92.01.81.8-1.71.71.81.81.91.1
Indifference point function log k1.83.13.92.01.81.8-1.71.71.81.81.91.1
Patch foraging total patch changes 0 sec4.89.111.93.43.43.2-3.32.93.03.32.71.5
Patch foraging total patch changes 12 sec0.81.01.71.31.21.3-1.10.90.91.00.50.1
Patch foraging total patch changes 18 sec0.00.10.20.30.20.5-0.3-0.00.10.2-0.4-0.1
Patch foraging total patch changes 24 sec1.42.44.52.11.81.7-1.81.61.31.50.9-0.3
Patch foraging total patch changes 6 sec0.10.20.40.60.40.4-0.50.40.30.50.30.1
Patch foraging time to switch 0 sec0.10.31.9-0.20.1-0.1-0.1-0.1-0.10.50.31.4
Patch foraging water rate 0 sec0.40.81.21.10.91.1-0.81.01.00.50.6-0.8
Patch foraging water rate 12 sec0.81.62.81.41.21.5-1.31.31.71.01.2-0.0
Patch foraging water rate 18 sec0.50.84.80.50.30.7-0.10.80.8-0.60.3-2.2
Patch foraging water rate 24 sec0.30.40.8-0.5-0.7-0.20.6-0.6-0.1-0.9-0.6-0.8
Patch foraging water rate 6 sec1.72.44.51.81.72.1-1.41.62.00.81.0-1.1
Seeking ratio, delayed vs. immediate footshock1.21.53.60.91.00.5-1.21.10.81.61.41.9
Distance traveled before self-admin0.70.91.51.01.21.2-1.01.01.10.70.5-0.6
Distance traveled after self-admin0.91.12.81.31.21.7-0.70.71.20.1-0.0-1.3
Extensor digitorum longus weight1.35.234.51.40.71.3-0.31.81.4-1.60.3-5.9
Bone: elastic displacement2.02.33.11.71.81.7-1.71.31.61.71.11.0
Bone: elastic work4.25.57.82.82.82.7-2.62.32.42.31.70.5
Bone: endosteal estimation0.30.61.01.01.01.0-0.90.70.60.90.30.1
Bone: endosteal perimeter1.02.23.31.71.81.6-1.71.31.21.80.90.8
Epididymis fat weight0.00.10.30.20.30.4-0.3-0.00.30.20.00.6
Delta time in closed arm before/after self-admin0.30.31.8-0.4-0.1-0.20.1-0.3-0.10.40.21.3
Delta time in open arm before/after self-admin0.10.10.2-0.1-0.3-0.20.20.1-0.1-0.20.2-0.5
Diff in mean of infusions in LGA sessions1.92.34.21.81.41.4-1.41.81.71.12.0-0.2
Delay discount exponential model param0.70.73.5-1.1-0.7-0.80.3-0.5-0.30.50.31.9
Extinction: sum of active levers before priming0.10.10.30.60.40.5-0.30.20.20.40.30.3
Active lever presses in extinction session 61.61.62.2-1.0-1.2-1.11.5-1.5-1.4-1.3-1.5-0.3
Bone: final force0.40.61.21.00.91.0-0.70.60.60.30.0-1.1
Bone: final moment0.81.32.21.41.41.5-1.21.11.10.80.5-0.9
Food consumed during 24 hour testing period0.60.81.21.11.01.0-0.91.01.00.70.7-0.4
Glucose1.21.93.1-1.2-1.3-1.11.4-1.2-1.3-1.7-1.6-1.5
Heart weight0.00.10.3-0.1-0.2-0.1-0.1-0.00.10.30.40.6
Delay discount hyperbolic model param0.70.82.9-1.3-0.9-1.00.4-0.6-0.50.30.11.7
Intermittent access intake day 1-15 change0.10.10.7-0.30.10.1-0.0-0.4-0.10.2-0.30.9
Intermittent access intake escalation0.00.10.5-0.20.20.2-0.1-0.20.10.3-0.00.7
Intermittent access intake escalation 20.00.00.1-0.10.10.1-0.0-0.10.20.10.00.4
Intermitt. access day 1 inactive lever presses0.31.13.3-1.1-1.1-1.50.9-0.8-0.8-0.10.31.8
Intermitt. access day 15 inactive lever presses0.20.51.6-1.0-1.3-0.90.8-0.3-0.1-0.50.30.1
Intermitt. access escalation Index0.10.10.4-0.10.2-0.3-0.20.1-0.40.40.10.7
Intermittent access day 1 total infusions0.30.41.4-0.5-0.2-0.30.7-0.7-0.7-0.7-1.2-0.6
Intermittent access day 15 total infusions0.50.81.6-1.3-0.6-0.70.9-1.1-0.9-0.6-1.10.4
Intermittent access terminal intake (last 3 days)1.31.72.7-1.6-1.2-1.31.3-1.5-1.4-1.2-1.6-0.3
Intermittent access total infusions2.02.33.5-1.8-1.3-1.51.6-1.9-1.7-1.2-1.80.2
Intermittent access day 1 locomotion0.00.00.10.10.3-0.0-0.00.1-0.20.20.10.2
Intermittent access day 15 total locomotion0.40.71.5-1.2-0.7-0.41.0-0.9-0.4-1.0-0.9-0.7
Intermittent access total locomotion0.10.20.3-0.6-0.4-0.40.6-0.5-0.4-0.4-0.4-0.0
Intermittent access standard deviation0.20.41.80.0-0.10.10.3-0.50.1-0.8-1.0-1.3
Left kidney weight0.31.32.71.11.00.9-1.01.61.20.91.7-0.6
Right kidney weight1.15.09.32.32.11.9-2.12.72.32.23.00.6
Cocaine induced anxiety1.62.33.21.41.41.5-1.81.81.71.61.70.2
Post-drug Anxiety3.43.65.91.31.61.6-2.22.11.92.42.41.2
Baseline Anxiety0.10.10.3-0.6-0.2-0.20.2-0.3-0.40.1-0.10.5
Tail length0.31.21.91.01.01.0-1.11.11.11.41.30.7
Length with tail1.15.06.12.32.42.2-2.32.42.32.32.50.9
Length without tail1.44.66.72.52.52.3-2.12.62.31.62.1-0.5
Times rat made contact with spout0.20.30.4-0.5-0.5-0.50.5-0.5-0.6-0.5-0.6-0.3
Lifetime Intake1.62.03.1-1.6-1.2-1.41.4-1.7-1.6-1.2-1.7-0.1
Liver weight, left2.13.55.12.11.91.8-1.82.32.21.52.1-0.2
Liver weight, right0.50.85.1-0.3-0.5-0.10.6-0.0-0.1-1.2-0.5-2.3
Locomotor activity7.010.914.13.63.63.6-3.53.63.83.03.20.0
Locomotor testing distance6.912.415.73.73.83.6-3.93.33.54.03.32.2
Locomotor testing rearing8.517.123.24.34.34.1-4.54.04.14.84.12.9
Locomotion in novel chamber0.00.10.3-0.1-0.1-0.20.20.0-0.3-0.10.0-0.5
Locomotion in novel chamber post-restriction0.20.31.5-0.00.10.10.1-0.2-0.2-0.6-0.8-1.2
Fecal boli incidents, locomotor time 10.40.63.30.70.30.9-0.00.20.6-0.6-0.5-1.8
Change in fecal boli incidents, locomotor task0.50.51.6-1.3-0.8-0.90.4-0.2-0.40.00.51.0
Time >=10cm from walls, locomotor time 10.91.02.40.60.80.3-1.11.10.71.31.61.1
Bouts of movement, locomotor time 10.20.20.5-0.3-0.4-0.50.4-0.3-0.3-0.6-0.5-0.7
Total resting periods, locomotor time 11.01.11.8-0.9-1.0-1.01.0-1.0-1.0-1.3-1.2-1.0
Rest time, locomotor task time 11.72.13.6-1.2-1.5-1.11.6-1.6-1.5-1.7-1.9-0.7
Distance moved, locomotor task time 10.30.51.10.10.60.2-0.80.70.41.10.91.0
Vertical activity count, locomotor time 11.53.65.22.12.31.9-2.12.11.91.91.7-0.1
Time >=10cm from walls, locomotor time 20.10.10.40.10.20.1-0.30.40.40.40.60.1
Bouts of movement, locomotor time 20.40.61.8-0.2-0.7-0.20.8-0.5-0.2-1.3-0.7-1.3
Total resting periods, locomotor time 20.81.43.4-0.6-1.1-0.61.3-0.9-0.6-1.8-1.0-1.8
Rest time, locomotor task time 24.15.29.7-1.4-2.0-1.42.3-1.9-1.8-3.1-2.7-3.1
Distance moved, locomotor task time 21.92.34.51.11.61.2-1.71.31.12.11.51.8
Vertical activity count, locomotor time 22.63.65.92.42.32.1-2.01.81.72.11.30.8
Light reinforcement 10.10.20.4-0.6-0.4-0.30.4-0.4-0.5-0.1-0.20.6
Light reinforcement 22.43.75.4-2.3-2.2-1.92.2-2.0-1.9-2.0-1.7-0.5
Bone: marrow area0.30.61.00.91.00.9-0.90.60.60.90.30.2
Bone: maximum diameter0.20.41.70.70.60.5-0.30.20.0-0.2-0.6-1.3
Bone: maximum force0.81.52.71.61.51.6-1.11.00.90.5-0.0-1.5
Bone: maximum moment1.52.64.62.12.02.1-1.71.61.41.00.5-1.3
Mean time between licks in bursts0.40.95.5-0.10.2-0.3-0.40.0-0.11.30.72.3
Mean num. licks in bursts0.10.20.40.60.40.6-0.50.30.50.40.1-0.0
Cd content in liver2.32.54.01.61.51.7-1.61.92.01.31.8-0.3
Co content in liver0.70.83.5-0.4-0.6-0.10.7-0.4-0.2-1.3-0.8-1.9
Cu content in liver0.20.20.8-0.3-0.4-0.50.5-0.2-0.3-0.7-0.2-0.9
Fe content in liver0.60.74.7-0.20.0-0.1-0.30.10.30.90.92.2
K content in liver1.21.22.4-1.3-1.1-1.51.0-1.1-1.4-0.6-0.60.7
Mg content in liver0.40.40.9-0.7-0.4-0.80.4-0.7-0.80.1-0.40.9
Mn content in liver0.20.21.2-0.00.20.1-0.2-0.3-0.20.6-0.21.1
Na content in liver4.14.46.32.32.32.3-2.12.52.41.52.1-0.9
Rb content in liver0.20.20.5-0.6-0.5-0.70.3-0.2-0.10.00.40.7
Se content in liver4.14.96.82.02.32.0-2.31.92.12.62.22.3
Sr content in liver0.70.61.40.30.50.6-0.70.60.71.01.01.2
Zn content in liver0.50.61.10.60.80.5-0.80.50.51.00.71.1
Bone: minimum diameter1.01.83.51.91.81.6-1.51.31.21.00.5-0.7
Time in familiar zone, hab. session 10.20.20.6-0.4-0.3-0.30.3-0.7-0.5-0.3-0.80.2
Time in novel zone, hab. session 10.40.41.8-0.3-0.6-0.40.6-0.0-0.1-0.9-0.1-1.3
Total zone transitions, hab. session 10.60.81.71.31.31.2-1.00.80.70.60.1-0.6
Total locomotion distance, hab. session 10.81.12.41.51.61.1-1.30.80.61.10.20.3
Locomotion velocity, hab. session 12.02.85.22.12.31.8-2.01.41.11.90.90.8
Time in familiar zone, hab. session 21.01.11.8-1.3-1.3-0.91.2-1.1-0.8-1.1-0.9-0.3
Time in novel zone, hab. session 20.50.51.11.01.10.7-0.90.70.50.70.40.1
Total zone transitions, hab. session 21.62.13.51.91.81.7-1.61.51.41.20.8-0.5
Total locomotion distance, hab. session 20.60.81.71.31.31.0-1.00.80.60.80.3-0.0
Locomotion velocity, hab. session 21.01.32.61.61.61.3-1.31.00.91.00.4-0.3
Novel to familiar place preference ratio0.30.40.80.90.90.7-0.70.30.40.6-0.10.4
Novelty place preference0.50.51.00.91.00.7-0.90.50.50.80.10.6
Time in novel zone, NPP test0.60.71.21.01.10.8-1.00.60.70.90.30.5
Total zone transitions, NPP test1.11.62.71.51.61.4-1.51.11.01.50.70.7
Total locomotion distance, NPP test1.42.04.81.31.61.0-1.50.80.52.00.82.2
Locomotion velocity, NPP test1.01.43.71.11.40.8-1.20.50.31.70.51.9
Intraocular pressure0.50.72.40.40.50.4-0.80.40.51.30.81.5
Delta distance traveled before/after self-admin0.20.20.80.30.00.40.3-0.10.2-0.6-0.3-0.9
Delta ambulatory time before/after self-admin0.30.30.90.60.40.9-0.00.00.6-0.4-0.4-1.0
Parametrial fat weight0.30.63.3-0.40.3-0.3-0.2-0.6-0.70.7-0.51.8
Pavlov. Cond. lever latency0.70.81.3-1.1-1.1-0.91.0-1.0-1.0-0.7-0.80.2
Pavlov. Cond. magazine entry latency0.20.20.70.30.30.2-0.40.60.60.40.90.3
Pavlov. Cond. change in total contacts2.12.23.81.91.81.8-1.51.61.60.80.8-1.1
Pavlov. Cond. index score0.81.01.61.11.00.9-0.91.31.10.61.2-0.4
Pavlov. Cond. latency score0.70.91.51.11.00.9-1.01.21.10.71.1-0.2
Pavlov. Cond. lever contacts0.60.71.01.00.90.8-0.91.00.90.60.9-0.1
Pavlov. Cond. magazine entry number0.40.51.0-0.8-0.6-0.50.6-1.0-0.8-0.3-1.00.6
Pavlov. Cond. intertrial magazine entries1.51.72.51.41.61.6-1.41.21.41.51.10.5
Pavlov. Cond. lever-magazine prob. diff.0.81.01.71.11.00.9-0.91.31.10.51.2-0.5
Pavlov. Cond. response bias0.30.30.70.70.50.4-0.50.80.70.10.7-0.6
Pavlov. Cond. lever latency2.02.73.7-1.9-1.7-1.81.6-1.9-1.9-1.3-1.60.4
Pavlov. Cond. magazine entry latency0.80.91.51.11.11.2-0.91.11.10.70.9-0.2
Pavlov. Cond. change in total contacts1.62.64.21.71.51.9-1.52.02.00.81.6-1.3
Pavlov. Cond. index score1.92.53.71.71.61.8-1.51.91.91.11.6-0.5
Pavlov. Cond. latency score2.12.84.01.81.71.8-1.72.02.01.31.8-0.2
Pavlov. Cond. lever contacts2.02.73.71.91.71.9-1.61.91.91.31.5-0.5
Pavlov. Cond. magazine entry number0.70.81.5-1.1-1.1-1.20.9-0.9-0.9-0.7-0.5-0.1
Pavlov. Cond. intertrial magazine entries0.91.38.8-0.5-0.1-0.7-0.1-0.8-0.71.2-0.13.0
Pavlov. Cond. lever-magazine prob. diff.1.62.13.01.61.51.7-1.41.71.70.91.4-0.6
Pavlov. Cond. response bias2.02.84.12.01.82.0-1.61.91.91.21.4-0.5
Time in closed arm before self-admin0.10.10.50.3-0.2-0.20.10.40.2-0.10.7-0.6
Time in closed arm after self-admin0.20.20.40.10.30.3-0.20.20.50.50.60.7
Time in open arm before self-admin0.60.61.30.91.11.1-0.80.20.70.80.00.6
Time in open arm after self-admin0.00.00.0-0.1-0.10.00.00.10.00.10.20.1
Bone: periosteal estimation0.40.71.51.21.21.1-1.00.70.60.70.0-0.6
Bone: periosteal perimeter0.71.32.11.41.51.3-1.31.01.01.20.50.2
Bone: post-yield work3.55.211.9-1.6-1.6-1.52.1-2.4-2.5-2.6-3.4-2.1
Progressive ratio test 1 active lever presses2.22.74.4-1.6-1.5-1.41.7-1.7-1.7-1.8-2.1-1.1
Progressive ratio test 1 breakpoint2.02.54.2-1.5-1.4-1.31.7-1.7-1.6-1.7-2.0-1.1
Progressive ratio test 1 inactive lever presses0.30.50.9-0.8-0.8-0.70.7-0.7-0.6-0.1-0.10.9
Progressive ratio test 2 active lever presses0.50.60.9-0.8-0.6-0.40.9-0.8-0.5-0.9-0.9-0.7
Progressive ratio test 2 breakpoint0.30.40.6-0.6-0.4-0.30.7-0.6-0.3-0.7-0.8-0.8
Progressive ratio test 2 inactive lever presses0.71.22.3-1.5-1.3-1.11.3-1.2-0.9-0.8-0.70.3
Incentive Sensitization - Responses0.81.12.01.11.31.3-0.91.01.40.91.0-0.2
Incentive Sensitization - Breakpoint0.91.12.01.11.31.3-0.91.01.40.91.0-0.1
Sum of active levers in priming session hrs 5-61.01.01.5-1.0-1.1-1.01.2-1.2-1.1-0.9-0.80.2
Progressive ratio0.30.40.80.40.60.6-0.50.90.70.20.7-0.8
Food seeking constrained by brief footshock3.64.45.6-2.3-2.3-2.32.4-2.2-2.1-2.2-1.8-0.3
Seeking ratio, punishment vs. effort1.31.92.8-1.4-1.5-1.41.5-1.7-1.4-1.4-1.40.1
Retroperitoneal fat weight0.10.31.4-0.40.1-0.30.1-0.6-0.60.2-0.41.2
Reaction time number correct0.10.20.4-0.6-0.6-0.40.5-0.4-0.3-0.3-0.20.3
Reaction time mean minus median0.51.22.00.91.01.2-1.11.21.41.01.40.5
Reaction time mean minus median AUC0.20.61.40.60.50.7-0.60.81.00.71.20.7
Reaction time num false alarms0.91.21.61.11.31.2-1.11.31.01.11.20.2
Reaction time num false alarms AUC0.71.11.61.11.21.3-1.01.21.10.91.0-0.3
Reaction time trials correct on left0.10.20.4-0.6-0.6-0.40.5-0.4-0.3-0.3-0.20.3
Reaction time trials on left0.10.20.4-0.7-0.6-0.50.5-0.5-0.3-0.3-0.20.4
Reaction time mean0.10.10.4-0.0-0.00.1-0.20.40.40.20.6-0.1
Reaction time mean AUC0.20.30.90.30.30.3-0.50.70.70.50.9-0.2
Median of all reaction times0.00.10.1-0.3-0.3-0.30.10.10.1-0.10.3-0.3
Reaction time omissions0.30.42.5-0.5-0.2-0.3-0.1-0.2-0.10.70.41.6
Reaction time false alarm rate0.40.61.00.91.00.9-0.80.90.70.60.7-0.4
Reaction time premature initiation rate0.10.10.60.2-0.1-0.00.1-0.00.1-0.5-0.2-0.8
Reaction time premature initiations0.10.20.5-0.2-0.5-0.30.5-0.4-0.1-0.7-0.4-0.6
Std. dev. reaction times0.10.10.30.10.10.2-0.30.40.50.30.60.1
Reaction time trials completed0.10.20.4-0.7-0.6-0.50.5-0.5-0.3-0.3-0.20.4
Reaction time trials AUC0.10.20.4-0.6-0.6-0.40.4-0.4-0.2-0.2-0.10.4
Run reversals in cocaine runway, females0.50.51.0-0.8-0.6-0.50.6-0.9-0.9-0.4-1.0-0.0
Run reversals in cocaine runway, males0.90.97.10.30.00.1-0.00.60.1-0.9-0.3-2.7
Latency to leave start box in cocaine runway0.10.10.10.0-0.4-0.10.2-0.30.0-0.2-0.4-0.2
Latency to leave start box in cocaine runway, F0.10.10.60.6-0.20.00.10.20.3-0.3-0.0-0.8
Latency to leave start box in cocaine runway, M0.10.10.3-0.2-0.10.1-0.1-0.20.10.3-0.00.5
Std. dev. time between licks in bursts3.44.68.41.82.21.9-2.41.61.72.91.92.6
Total sessions with >9 infusions0.50.61.1-1.0-0.7-0.90.9-0.8-1.0-0.6-0.7-0.0
Short access day 1 total inactive lever presses1.21.53.8-0.9-1.2-1.11.1-0.9-1.0-1.4-1.3-2.0
Short access day 10 total inactive lever presses0.00.00.1-0.0-0.2-0.20.1-0.3-0.30.0-0.20.2
Short access day 1 total infusions1.72.33.1-1.4-1.5-1.71.6-1.6-1.7-1.4-1.7-0.7
Short access day 10 total infusions0.20.20.50.40.40.6-0.1-0.00.1-0.2-0.7-0.7
Short access total infusions0.30.41.1-0.5-0.3-0.40.6-0.7-0.7-0.7-1.0-0.7
Short access day 1 locomotion0.20.30.50.70.70.6-0.30.50.50.20.2-0.5
Short access day 10 total locomotion0.10.10.50.30.30.1-0.20.40.30.40.70.3
Short access total locomotion0.20.30.40.50.60.6-0.40.70.50.40.6-0.3
One hour access (0.3 mA shock)0.60.72.2-0.7-0.1-0.40.8-1.1-1.0-0.7-1.5-0.2
Compulsive drug intake0.20.31.6-0.00.2-0.2-0.1-0.0-0.50.60.21.3
One hour access (shock baseline)0.40.61.7-0.8-0.3-0.40.8-1.0-0.7-0.8-1.3-0.6
Social response proportion1.82.03.6-1.7-1.7-1.91.5-1.5-1.4-1.0-0.80.9
Social responses0.70.97.2-0.2-0.0-0.3-0.2-0.5-0.10.90.22.7
Social time1.41.93.11.11.31.0-1.31.51.31.71.81.2
Soleus weight0.30.72.0-0.5-0.7-0.60.9-0.5-0.7-1.2-0.9-1.4
Bone: stiffness0.20.31.50.50.30.6-0.20.40.3-0.2-0.0-1.2
Tibialis anterior weight1.24.222.71.71.11.5-0.72.11.6-0.80.9-4.8
Time to tail flick, vehicle, before self-admin0.10.10.3-0.0-0.4-0.60.2-0.0-0.4-0.10.10.1
Time to tail flick, vehicle, after self-admin1.01.32.8-1.2-1.3-1.01.1-0.7-0.7-1.5-0.7-1.7
Time to tail flick, test, before self-admin0.20.20.60.20.30.2-0.50.3-0.00.80.40.7
Time to tail flick, test, after self-admin2.32.45.0-2.2-1.7-1.91.3-1.7-1.6-0.6-0.91.3
Delta time to tail flick, vehicle, before/after SA1.61.53.0-1.7-1.4-1.11.2-1.2-0.9-1.4-1.0-1.0
Delta time to tail flick, test, before/after SA3.43.55.9-2.4-2.3-2.22.0-2.1-1.8-1.4-1.30.7
Tibia length3.810.414.33.13.23.0-3.33.53.33.63.81.8
Ambulatory time before self-admin0.30.40.70.80.80.8-0.70.60.70.40.1-0.7
Ambulatory time after self-admin1.61.94.51.51.52.1-0.91.01.70.10.1-1.9
Bone: tissue strength0.30.30.60.70.80.7-0.70.60.40.70.2-0.1
Total heroin consumption0.40.53.00.90.20.20.10.40.1-0.6-0.3-1.7
Bone: trabecular number0.30.53.1-0.10.20.1-0.30.00.11.00.61.8
Bone: trabecular spacing0.30.42.60.2-0.00.20.20.10.0-0.9-0.5-1.6
Bone: trabecular thickness0.30.40.60.70.80.8-0.60.60.50.60.30.1
Bone: trabecular tissue density0.30.41.50.40.30.5-0.30.80.8-0.20.7-1.2
Water consumed over 24 hours0.30.41.50.70.50.7-0.50.70.60.10.3-1.2
Number of responses in last shaping day0.40.41.80.60.40.8-0.20.40.6-0.3-0.1-1.4