Eif4e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	XM_063281173.1	0.04	0.02	3.6e-05	0.02	0.03	0.02	0.03	3.6e-04	1.1e-05	2.0e-04	1.3e-05
2	PL	alternative TSS	NM_053974.2	0.11	0.07	1.6e-05	0.04	0.04	0.04	0.04	5.3e-05	6.7e-05	8.9e-05	4.4e-05
3	Brain	gene expression	Eif4e	0.06	0.04	2.8e-04	0.02	0.04	0.03	0.03	4.7e-03	1.8e-04	1.5e-03	1.3e-03
4	NAcc	isoform ratio	XM_063281174.1	0.04	0.03	2.7e-03	0.03	0.01	0.02	0.03	8.8e-05	1.8e-03	2.0e-04	8.9e-05
5	PL	gene expression	Eif4e	0.04	0.02	1.4e-03	0.03	0.02	0.01	0.02	4.3e-04	2.7e-03	1.4e-02	3.3e-03
6	BLA	gene expression	Eif4e	0.08	0.05	6.0e-03	0.03	0.02	0.02	0.02	1.5e-02	1.9e-02	4.1e-02	3.0e-02
7	IC	alternative TSS	NM_053974.2	0.21	0.1	3.2e-04	-0.01	0.05	0.03	0	8.9e-01	4.9e-03	2.1e-02	2.2e-01
8	Adipose	gene expression	Eif4e	0.03	0.02	7.2e-03	-0	-0	0	-0	5.7e-01	3.8e-01	3.4e-01	8.2e-01
9	NAcc	alternative TSS	XM_063281175.1	0.05	0.03	1.1e-06	0.05	0.05	0.04	0.04	1.3e-07	8.4e-08	2.5e-07	2.7e-07
10	OFC	intron excision ratio	chr2_229762590_229765229	0.29	0.12	2.4e-04	0.13	0.03	0.03	0.1	6.3e-04	6.0e-02	5.4e-02	3.0e-03
11	NAcc	gene expression	Eif4e	0.09	0.04	3.9e-12	0.07	0.09	0.08	0.08	7.5e-11	3.8e-13	3.2e-12	9.7e-12
12	PL	isoform ratio	XM_063281174.1	0.04	0.03	4.5e-03	0	0.02	0.01	0.01	1.6e-01	6.6e-03	6.3e-02	5.1e-02
13	LHb	intron excision ratio	chr2_229740783_229761142	0.24	0.12	4.1e-03	0.02	0.07	0.07	0.04	8.9e-02	8.5e-03	7.5e-03	4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.6	1.0	3.7	1.9	-0.9	1.0	-0.0	0.8	0.8	-1.3	1.3	-1.1	-0.1	1.1	-0.4	0.3
Area under the delay curve	0.6	0.8	1.7	-0.9	-0.7	-1.3	0.4	-0.9	-0.9	-0.1	-1.0	1.2	-0.0	-0.8	1.1	-0.7
BMI with tail	0.7	2.5	7.8	0.1	2.8	2.3	-1.7	2.1	2.0	0.2	0.9	-0.9	-2.0	0.6	-1.1	-1.2
BMI without tail	0.7	2.2	5.2	0.3	2.3	2.0	-2.0	1.7	1.7	-0.6	0.5	-0.7	-2.1	0.1	-0.7	-1.7
Body weight	1.0	4.5	14.9	0.2	3.9	2.8	-2.8	2.8	2.7	0.6	1.0	-1.6	-2.2	0.6	-1.8	-1.0
Weight adjusted by age	1.0	1.5	3.5	-1.9	-0.1	-1.3	0.9	-0.5	-0.7	0.3	-1.5	1.9	-0.3	-1.2	1.5	-1.6
Bone surface	0.4	0.7	2.8	1.7	-0.7	0.8	-0.2	0.5	0.5	-1.1	1.3	-1.1	0.1	0.8	-0.6	0.3
Bone volume	0.5	0.9	3.2	1.8	-0.6	0.9	-0.7	0.4	0.4	-1.1	1.3	-1.4	0.5	0.6	-0.8	0.3
Breakpoint value in progressive ratio session	0.5	0.6	1.9	0.3	0.7	1.1	-0.4	1.4	1.3	0.3	0.3	-0.3	-0.6	1.1	-0.3	0.9
Number of licking bursts	0.8	1.3	4.1	-0.9	2.0	1.3	0.5	1.1	1.1	1.8	0.7	-0.2	-1.2	1.3	-1.1	-0.1
Context. condit. distance diff. score	0.4	0.5	1.7	0.2	0.4	0.4	0.6	1.0	1.0	0.5	0.4	-0.0	-0.6	1.3	-0.2	0.9
Locomotion velocity, session 1	1.3	1.4	4.5	-2.1	1.2	-0.8	-0.5	-0.9	-0.9	1.3	-1.5	1.0	-0.3	-1.6	0.4	-1.5
Locomotion distance, session 1	2.3	2.9	10.5	-3.2	1.6	-1.3	0.2	-1.3	-1.3	2.5	-2.3	1.8	-0.6	-1.6	0.8	-0.9
Locomotion velocity, session 2	1.0	1.1	2.2	-1.5	-0.2	-0.9	1.0	-1.1	-1.1	0.4	-1.5	1.5	-0.2	-1.0	1.2	-1.0
Locomotion distance, session 2	5.2	7.2	20.1	-4.5	0.8	-3.0	0.4	-2.9	-2.9	2.7	-3.7	3.1	0.4	-3.1	2.1	-1.5
Locomotion velocity, session 3	1.0	1.1	4.5	-1.5	1.8	-0.6	-0.9	-0.8	-0.7	2.1	-0.7	-0.1	0.8	-0.8	-0.8	0.5
Locomotion distance, session 3	0.2	0.2	0.8	-0.8	0.3	-0.4	-0.1	-0.3	-0.3	0.9	-0.4	0.4	0.1	-0.2	0.0	0.0
Stereotopy head waving bouts, day 3	0.4	0.4	1.1	-0.7	1.1	-0.0	-1.0	-0.6	-0.6	0.9	-0.1	-0.3	0.4	-0.7	-0.7	-0.3
Stereotopy head waving duration, day 3	0.8	1.0	3.9	-0.2	2.0	1.0	-1.5	0.3	0.4	1.2	0.6	-1.1	-0.0	0.1	-1.6	0.2
Locomotion velocity, session 7	0.7	0.8	2.5	-1.5	1.2	0.2	0.8	0.2	0.3	1.1	-0.4	0.8	-1.2	-0.2	0.2	-1.6
Locomotion distance, session 7	0.8	1.1	3.2	-1.8	0.9	-0.2	1.0	0.4	0.4	1.3	-1.1	1.5	-1.3	0.1	0.9	-0.8
Stereotopy head waving bouts, day 7	1.4	1.5	4.3	-0.5	-0.3	-1.4	-1.4	-2.0	-2.0	0.5	-0.6	-0.2	2.1	-1.7	-0.2	0.6
Stereotopy head waving duration, day 7	1.8	2.2	6.0	-0.7	-0.1	-1.5	-1.6	-2.3	-2.3	1.0	-0.7	-0.4	2.4	-1.9	-0.4	0.7
Locomotion velocity, session 8	0.5	0.5	1.6	-1.3	0.1	-0.8	0.8	-0.5	-0.5	0.6	-0.8	1.1	-0.3	-0.5	0.6	-1.0
Locomotion distance, session 8	2.1	3.0	11.3	-3.4	1.6	-1.5	0.7	-0.9	-0.9	2.7	-2.4	2.3	-0.7	-1.1	1.2	-0.4
Degree of sensitization distance	0.7	0.7	2.3	-0.2	0.4	0.7	1.2	1.1	1.1	-0.1	-0.1	0.7	-1.5	1.0	0.5	-0.4
Degree of sensitization stereotypy	1.4	1.5	4.5	-0.0	-0.8	-1.4	-1.5	-1.9	-1.9	-0.1	-0.5	-0.2	2.1	-1.6	0.1	0.8
Conditioned locomotion	0.9	1.0	3.8	0.9	-1.9	-1.0	0.1	-0.9	-0.9	-1.6	0.1	-0.1	1.5	-0.9	0.5	-0.0
Cocaine response after cond. corrected	0.2	0.2	0.8	0.3	-0.4	0.1	0.3	-0.1	-0.1	-0.9	0.4	-0.1	0.4	-0.3	0.2	-0.9
Cocaine response after cond. not corrected	0.8	0.9	3.4	0.3	-1.4	-0.2	1.0	-0.3	-0.3	-1.9	-0.0	0.8	0.4	-0.5	1.3	-1.6
Cocaine response before conditioning	0.4	0.4	1.2	-0.3	-0.8	-0.5	0.6	-0.2	-0.1	-0.8	-0.7	1.0	-0.2	-0.3	1.1	-0.9
Saline control response	1.7	2.3	4.8	-1.7	0.3	-2.1	-0.2	-2.2	-2.1	1.4	-1.9	0.9	1.9	-1.7	0.3	0.9
Bone: connectivity density	0.5	0.7	1.9	1.4	-1.4	0.3	0.9	0.6	0.6	-0.9	0.9	-0.4	-0.1	1.2	0.1	0.8
Bone: cortical apparent density	0.1	0.2	0.5	-0.3	0.6	0.5	-0.4	0.5	0.5	0.4	-0.3	0.1	-0.7	0.2	-0.1	-0.2
Bone: cortical area	2.4	3.6	8.7	1.9	1.9	3.0	-1.7	2.3	2.3	-0.6	2.1	-2.3	-1.0	1.6	-2.1	-0.2
Bone: cortical porosity	0.3	0.4	1.1	-0.9	0.7	-0.4	-0.5	-0.6	-0.6	0.5	-0.5	0.3	0.3	-1.0	0.1	-0.6
Bone: cortical porosity	0.3	0.4	1.1	-0.9	1.1	-0.2	-0.7	-0.4	-0.4	0.5	-0.5	0.1	0.0	-1.0	-0.1	-0.6
Bone: cortical thickness	2.7	4.5	10.7	2.2	2.0	3.3	-1.9	2.7	2.7	-0.7	2.4	-2.4	-1.1	1.9	-2.1	-0.1
Bone: cortical thickness	0.9	1.1	2.6	1.2	0.4	1.5	-0.9	1.4	1.4	-1.6	0.8	-0.8	-0.6	0.4	-0.3	-1.0
Bone: cortical tissue density	0.1	0.2	0.5	-0.4	0.7	0.4	-0.4	0.5	0.5	0.5	-0.4	0.2	-0.7	0.2	-0.1	-0.1
Condit. Reinf. active minus inactive responses	1.2	1.4	5.5	-2.1	2.3	-0.0	-0.6	-0.1	-0.1	2.1	-0.8	0.7	-1.0	-0.5	-0.3	-0.8
Condit. Reinf. active-inactive response ratio	2.4	2.6	13.2	-1.6	3.6	1.4	-1.4	1.2	1.2	2.4	0.1	-0.3	-1.7	0.3	-1.4	-0.8
Condit. Reinf. active responses	1.5	1.9	5.5	-2.3	0.7	-1.5	-0.1	-1.5	-1.5	1.5	-1.8	1.7	0.1	-1.4	1.0	-0.4
Condit. Reinf. inactive responses	2.1	2.6	5.2	-0.4	-2.3	-2.2	0.3	-2.3	-2.3	-0.8	-1.5	1.3	1.8	-1.5	1.7	0.7
Incentive salience index mean	0.5	0.6	3.4	-1.2	1.9	0.3	-0.2	0.2	0.2	1.3	-0.2	0.4	-0.9	0.0	-0.4	-0.6
Condit. Reinf. lever presses	0.2	0.2	0.7	0.5	0.6	0.5	-0.0	0.2	0.1	0.1	0.8	-0.7	0.2	0.6	-0.8	0.4
Condit. Reinf. active minus inactive responses	1.4	1.8	3.9	1.9	0.4	1.8	-0.0	1.2	1.2	-0.8	2.0	-1.9	-0.5	1.5	-1.8	0.2
Condit. Reinf. active-inactive response ratio	2.3	2.7	5.3	1.9	1.0	2.3	-0.2	1.7	1.7	-0.2	2.2	-2.1	-0.8	2.1	-2.1	0.6
Condit. Reinf. active responses	0.9	1.2	2.3	1.4	0.4	1.5	0.1	1.2	1.2	-1.0	1.5	-1.3	-0.8	1.1	-1.2	-0.3
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.6	0.3	-0.3	0.2	0.3	0.3	-0.2	-0.4	0.5	-0.5	-0.5	0.2	-0.5
Condit. Reinf. lever presses	0.6	0.9	1.9	1.2	0.0	1.1	0.5	1.3	1.3	-1.4	0.8	-0.4	-1.1	1.2	-0.3	0.1
Condit. Reinf. lever reinforcers received	0.7	1.0	1.9	1.4	0.1	1.4	0.0	1.2	1.1	-1.1	1.3	-1.1	-0.9	1.0	-1.0	-0.3
Conditioned reinforcement - actives	1.2	2.1	7.9	-1.1	1.1	-1.4	-0.8	-1.0	-1.1	2.8	-0.4	-0.7	1.7	-0.8	-1.3	2.5
Conditioned reinforcement - inactives	0.7	1.0	2.4	-0.8	-0.3	-1.6	0.1	-1.4	-1.4	0.7	-1.6	0.8	0.9	-1.0	0.7	0.4
Conditioned locomotion	1.0	1.3	8.9	0.8	-1.1	-1.1	0.6	-0.5	-0.4	0.6	0.4	-0.8	1.5	0.5	-0.6	3.0
Patch foraging indifference point 0 sec	0.3	0.6	2.9	-0.7	-0.4	-1.0	1.7	-0.1	-0.2	0.6	-0.5	1.0	-0.2	0.3	0.7	0.8
Patch foraging indifference point AUC	0.8	1.1	2.9	1.0	0.8	1.7	-0.3	1.2	1.4	-0.1	1.2	-1.1	-0.7	1.4	-1.1	0.6
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	0.7	-0.5	-0.3	0.2	-0.0	-0.3	0.1	0.8	-0.6	0.3	0.7	-0.7	0.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	-0.9	0.4	-0.5	0.0	-0.4	-0.4	0.7	-0.8	0.6	-0.4	-0.4	0.4	-0.4
Delay disc. indifference point, 2s delay	0.6	0.7	2.7	0.9	-1.7	-0.9	-0.2	-0.9	-1.1	-0.8	0.4	-0.4	1.0	-0.3	0.1	0.3
Delay disc. indifference point, 24s delay	0.8	0.9	1.9	-0.2	-1.1	-1.2	0.6	-1.0	-1.1	-0.9	-0.8	1.1	0.6	-0.7	1.4	-0.8
Delay disc. indifference point, 4s delay	0.6	0.6	1.5	-0.4	-1.0	-0.5	0.9	-0.1	0.0	-0.8	-0.6	1.2	-0.9	-0.1	1.2	-0.8
Delay disc. indifference point, 8s delay	2.4	2.8	5.5	-2.3	-0.2	-2.3	0.0	-1.9	-2.0	0.7	-2.3	2.0	0.6	-2.2	1.6	-0.8
Indifference point function ln k	0.9	1.5	5.0	-2.2	0.7	-1.3	0.7	-0.9	-1.1	1.2	-1.8	1.7	-0.1	-1.2	1.1	-0.7
Indifference point function log k	0.9	1.5	5.0	-2.2	0.7	-1.3	0.7	-0.9	-1.1	1.2	-1.8	1.7	-0.1	-1.2	1.1	-0.7
Patch foraging total patch changes 0 sec	0.3	0.6	2.9	-0.8	-0.3	-1.0	1.7	0.0	-0.0	0.7	-0.6	1.0	-0.3	0.3	0.7	0.9
Patch foraging total patch changes 12 sec	0.3	0.4	1.0	0.1	0.5	0.5	1.0	0.9	1.0	-0.1	0.3	0.3	-0.8	0.9	0.1	0.4
Patch foraging total patch changes 18 sec	0.4	0.6	1.7	-0.4	0.6	0.1	1.3	0.8	0.9	0.9	0.2	0.3	-1.1	1.0	-0.1	0.9
Patch foraging total patch changes 24 sec	0.3	0.5	2.0	-0.7	1.0	-0.3	0.3	0.1	0.1	1.4	0.0	-0.1	-0.3	0.2	-0.7	1.3
Patch foraging total patch changes 6 sec	1.6	2.4	6.5	1.2	0.3	1.6	1.4	2.4	2.4	-0.4	1.3	-0.3	-1.8	2.5	-0.4	1.3
Patch foraging time to switch 0 sec	0.2	0.4	0.8	0.4	-0.9	-0.7	-0.7	-0.8	-0.9	-0.3	0.1	-0.3	0.8	-0.7	0.2	-0.5
Patch foraging water rate 0 sec	0.3	0.5	1.2	0.4	0.8	1.1	0.3	0.9	1.1	0.1	0.6	-0.4	-0.6	1.1	-0.6	0.7
Patch foraging water rate 12 sec	0.3	0.6	3.0	-0.7	1.7	0.8	-0.7	0.8	0.8	0.8	-0.1	-0.1	-0.8	-0.0	-0.6	-0.3
Patch foraging water rate 18 sec	1.5	2.3	6.0	0.9	1.2	2.4	0.1	2.1	2.2	-0.3	1.8	-0.9	-1.8	1.9	-1.2	-0.2
Patch foraging water rate 24 sec	0.8	1.1	2.6	-0.6	1.5	1.4	0.5	1.4	1.5	1.0	0.4	-0.0	-1.6	1.1	-0.7	-0.5
Patch foraging water rate 6 sec	1.3	1.9	6.5	-2.1	2.6	1.1	0.0	0.9	1.1	1.2	-1.1	1.2	-2.2	-0.1	0.2	-1.2
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	6.4	0.6	-2.5	-1.5	1.1	-0.9	-1.2	-1.8	-0.8	1.0	0.7	-0.6	1.8	-0.1
Distance traveled before self-admin	0.7	0.9	3.1	1.1	0.0	0.3	-1.2	-0.5	-0.4	0.2	0.7	-1.4	1.6	0.1	-1.0	1.8
Distance traveled after self-admin	0.1	0.1	0.4	-0.2	0.2	0.1	-0.1	-0.0	0.1	0.7	-0.2	-0.1	0.0	0.2	-0.2	0.7
Extensor digitorum longus weight	1.8	7.1	33.6	1.0	4.2	3.1	-5.8	1.9	1.9	0.3	1.3	-3.2	-0.9	-0.8	-3.0	-1.0
Bone: elastic displacement	0.8	1.0	2.2	0.8	1.2	1.5	-1.1	1.1	1.1	-0.1	1.1	-1.2	-0.5	0.6	-1.2	-0.3
Bone: elastic work	2.5	3.2	7.8	1.4	1.9	2.8	-1.1	2.3	2.3	-0.5	2.2	-1.8	-1.5	1.5	-1.8	-0.9
Bone: endosteal estimation	0.0	0.0	0.1	0.0	0.1	0.0	-0.1	-0.2	-0.2	0.1	0.2	-0.1	0.2	0.0	-0.3	0.2
Bone: endosteal perimeter	0.2	0.4	1.2	0.2	0.8	0.5	-1.1	-0.1	-0.1	0.6	0.4	-0.9	0.4	0.1	-1.1	0.2
Epididymis fat weight	0.4	1.2	3.6	-0.0	1.9	1.5	-0.6	1.4	1.4	0.7	1.0	-1.0	-1.0	0.6	-1.3	-0.3
Delta time in closed arm before/after self-admin	0.8	0.7	2.2	-1.5	0.8	-0.9	-0.3	-1.0	-0.9	1.4	-0.6	0.5	0.2	-0.9	-0.3	0.1
Delta time in open arm before/after self-admin	1.1	1.1	3.2	-0.6	0.6	-1.5	-0.4	-1.3	-1.3	1.0	-0.6	-0.3	1.8	-1.4	-0.5	0.8
Diff in mean of infusions in LGA sessions	1.0	1.2	4.6	-0.2	-0.5	0.7	2.1	1.1	1.3	-0.6	-0.0	1.1	-1.7	1.2	0.9	-0.7
Delay discount exponential model param	0.8	0.9	2.0	0.9	0.8	1.3	-0.5	0.8	0.9	0.3	1.2	-1.4	0.1	0.9	-1.4	0.8
Extinction: sum of active levers before priming	1.2	1.3	3.5	0.8	0.4	1.4	-0.4	1.8	1.7	-1.2	0.2	-0.1	-1.8	0.6	0.4	-1.9
Active lever presses in extinction session 6	0.5	0.5	2.9	-0.3	-0.6	-0.3	1.7	0.4	0.4	0.5	-0.2	0.5	-0.4	0.7	0.4	0.9
Bone: final force	0.6	1.0	2.2	0.5	1.2	1.5	-0.2	1.5	1.5	0.1	0.9	-0.8	-1.0	1.2	-1.0	0.1
Bone: final moment	0.7	1.1	2.4	0.7	1.1	1.6	0.1	1.5	1.5	-0.2	1.0	-0.7	-1.1	1.3	-0.9	-0.1
Food consumed during 24 hour testing period	0.6	0.8	2.5	-1.4	1.3	0.3	-0.2	0.2	0.2	0.6	-1.4	0.8	-1.6	-0.8	0.4	-1.0
Glucose	0.6	1.0	3.3	-0.5	1.2	1.3	0.3	1.2	1.2	-0.3	-0.1	0.6	-1.8	0.3	0.5	-1.5
Heart weight	0.8	1.2	2.5	1.0	1.3	1.5	-1.1	1.0	1.1	-0.3	1.6	-1.5	-0.0	0.6	-1.5	-0.1
Delay discount hyperbolic model param	0.8	0.9	1.8	0.7	1.0	1.3	-0.6	0.9	0.9	0.4	1.0	-1.3	-0.1	0.8	-1.3	0.7
Intermittent access intake day 1-15 change	0.1	0.2	1.1	0.5	-1.1	-0.4	0.0	-0.6	-0.7	-0.4	0.0	-0.3	0.5	-0.3	0.1	0.4
Intermittent access intake escalation	0.2	0.4	1.8	0.9	-1.3	-0.2	0.5	-0.3	-0.4	-0.8	0.3	-0.4	0.5	0.1	0.2	0.5
Intermittent access intake escalation 2	0.6	0.7	2.5	1.6	-0.9	0.8	0.2	0.5	0.5	-1.1	1.1	-1.0	-0.2	0.8	-0.4	0.3
Intermitt. access day 1 inactive lever presses	0.2	0.9	2.5	-1.5	0.0	-1.0	0.7	-0.7	-0.4	0.1	-1.6	1.6	-0.3	-1.0	1.2	-0.6
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.6	-0.5	0.3	-0.2	-0.1	-0.7	-0.6	-0.1	-0.5	0.5	0.1	-0.8	0.2	-0.4
Intermitt. access escalation Index	0.2	0.2	1.0	0.4	0.0	-0.3	-0.2	-0.6	-0.6	-0.5	0.2	-0.4	1.0	-0.5	-0.3	0.1
Intermittent access day 1 total infusions	0.5	0.8	2.1	-1.2	1.4	0.4	0.2	1.2	1.0	0.6	-0.5	0.7	-1.4	-0.2	0.2	-0.8
Intermittent access day 15 total infusions	0.3	0.5	1.8	0.1	0.4	0.8	0.4	1.4	1.1	-0.2	0.3	-0.1	-1.3	0.4	-0.1	-0.4
Intermittent access terminal intake (last 3 days)	0.5	0.6	2.2	-0.6	1.1	0.7	0.2	1.3	1.0	0.6	-0.1	0.1	-1.5	0.2	-0.2	-0.4
Intermittent access total infusions	0.8	0.9	3.3	-1.0	1.5	0.7	0.0	1.4	1.2	0.8	-0.3	0.4	-1.8	0.1	-0.1	-0.7
Intermittent access day 1 locomotion	0.4	0.5	1.7	-0.4	1.3	0.6	-0.4	1.2	1.1	0.7	0.1	-0.1	-0.6	0.4	-0.5	0.1
Intermittent access day 15 total locomotion	0.3	0.6	1.5	1.0	-0.5	0.7	0.1	0.8	0.7	-0.1	0.8	-1.0	-0.1	0.9	-0.7	1.2
Intermittent access total locomotion	0.4	0.5	1.3	0.6	0.5	1.0	-0.3	1.1	1.1	0.0	0.7	-0.7	-0.6	0.9	-0.6	0.3
Intermittent access standard deviation	0.5	1.0	2.8	0.9	0.6	1.4	-1.7	1.2	1.3	-0.0	0.9	-1.3	-0.6	0.7	-1.0	0.0
Left kidney weight	0.4	1.9	6.0	0.3	2.4	1.9	-2.4	1.7	1.7	0.1	0.4	-1.1	-1.4	0.1	-1.0	-0.3
Right kidney weight	0.5	2.2	6.7	0.5	2.4	2.0	-2.6	1.7	1.6	0.3	0.7	-1.6	-1.1	0.3	-1.5	-0.3
Cocaine induced anxiety	0.2	0.3	0.9	0.4	0.1	0.5	0.6	0.2	0.3	0.3	0.8	-0.5	-0.0	0.9	-0.7	0.5
Post-drug Anxiety	0.2	0.2	0.6	0.6	-0.3	0.1	0.7	-0.2	-0.2	-0.0	0.8	-0.4	0.2	0.7	-0.4	-0.0
Baseline Anxiety	0.1	0.1	0.7	-0.0	0.3	0.1	-0.4	0.0	-0.0	-0.3	-0.0	0.0	-0.3	-0.4	0.2	-0.8
Tail length	0.2	0.6	2.3	0.9	0.7	0.8	-1.5	0.5	0.5	-0.3	0.7	-1.2	-0.1	0.1	-1.0	0.2
Length with tail	0.3	1.4	3.1	0.5	1.8	1.5	-1.6	1.5	1.6	0.2	0.8	-1.3	-1.0	0.3	-1.2	-0.1
Length without tail	0.3	0.9	1.9	0.2	1.3	1.0	-0.5	1.1	1.1	0.8	1.0	-1.1	-0.2	0.8	-1.4	0.8
Times rat made contact with spout	0.9	1.0	3.2	-0.1	-0.3	0.9	1.1	1.2	1.1	-0.9	-0.3	0.8	-1.8	0.6	0.9	-1.6
Lifetime Intake	0.6	0.7	2.4	-1.4	1.5	0.2	-0.1	0.9	0.7	1.2	-0.7	0.6	-1.3	-0.3	0.0	-0.5
Liver weight, left	0.4	0.6	1.6	0.2	1.2	0.7	-0.8	0.3	0.2	1.1	0.5	-1.2	0.5	0.5	-1.3	0.6
Liver weight, right	1.4	2.5	4.6	1.0	1.7	2.1	-0.5	1.8	1.8	1.0	1.8	-1.9	-0.7	2.0	-2.1	0.7
Locomotor activity	0.3	0.5	1.3	-0.7	-0.4	-0.2	1.2	-0.4	-0.2	-0.4	-1.0	1.1	-0.3	-0.2	1.0	-0.9
Locomotor testing distance	0.6	1.1	2.8	-1.1	-0.6	-0.6	1.5	-0.2	-0.1	-0.7	-1.3	1.7	-0.7	-0.7	1.4	-1.3
Locomotor testing rearing	2.0	4.0	13.1	-1.3	-0.2	0.5	3.6	1.5	1.7	-1.5	-0.8	2.7	-3.3	0.7	2.2	-2.5
Locomotion in novel chamber	1.7	2.2	9.5	2.4	-3.1	0.1	1.6	0.4	0.4	-2.6	0.8	-0.1	0.2	1.2	1.1	-0.2
Locomotion in novel chamber post-restriction	0.6	1.0	2.4	-0.4	-1.3	-0.7	0.4	-1.3	-0.9	-1.0	-1.2	1.2	0.6	-1.0	1.5	-0.9
Fecal boli incidents, locomotor time 1	0.5	0.7	1.6	-1.1	-0.3	-1.0	0.5	-1.3	-1.2	0.7	-0.8	0.5	0.9	-1.1	0.3	-0.6
Change in fecal boli incidents, locomotor task	0.8	0.8	2.4	-0.5	0.1	0.3	0.8	0.3	0.3	-1.1	-0.7	1.4	-1.5	0.1	1.3	-1.1
Time >=10cm from walls, locomotor time 1	1.6	1.7	4.5	1.6	-0.5	1.8	0.9	1.5	1.6	-0.9	1.4	-0.6	-1.3	2.1	-0.2	0.5
Bouts of movement, locomotor time 1	0.7	0.8	2.8	1.0	-0.4	1.1	0.0	1.6	1.7	-1.0	0.8	-0.3	-0.4	1.0	0.1	-0.4
Total resting periods, locomotor time 1	0.4	0.5	1.8	0.5	-0.2	0.8	0.3	1.3	1.4	-0.6	0.6	-0.1	-0.6	0.7	0.1	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.9	0.2	-0.3	-0.7	0.7	-0.2	-0.1	-0.4	0.5	-0.4	0.9	-0.5	-0.4	0.1
Distance moved, locomotor task time 1	0.2	0.3	1.0	-0.6	0.2	0.2	-0.4	-0.2	-0.3	0.0	-0.7	1.0	-0.8	-0.0	0.8	-0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.4	-0.0	0.1	0.3	-0.7	-0.0	-0.1	0.0	-0.4	0.4	-0.5	0.3	0.4	-0.2
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.3	-0.7	1.1	0.1	-1.1	-0.4	-0.4	0.9	-0.1	-0.3	0.2	-0.6	-0.6	0.7
Bouts of movement, locomotor time 2	0.3	0.5	2.0	0.6	-1.4	-0.5	0.2	0.1	0.2	-0.7	0.2	0.2	0.9	0.3	0.5	1.3
Total resting periods, locomotor time 2	0.3	0.5	2.3	0.5	-1.5	-0.7	0.7	0.1	0.2	-0.8	0.2	0.4	0.7	0.3	0.7	1.2
Rest time, locomotor task time 2	0.5	0.6	2.6	1.0	-1.4	-0.4	1.2	0.2	0.1	-1.6	0.3	-0.1	0.2	-0.1	0.5	-0.3
Distance moved, locomotor task time 2	0.3	0.4	1.3	-0.8	0.4	-0.4	-0.6	-0.8	-0.9	1.1	-0.3	0.2	0.1	-0.2	-0.3	1.0
Vertical activity count, locomotor time 2	0.2	0.3	2.2	0.2	0.2	0.0	-1.5	-0.4	-0.4	0.4	0.1	-0.4	0.5	-0.1	-0.3	0.7
Light reinforcement 1	0.4	0.9	2.8	-1.7	1.6	0.0	-0.6	0.4	0.5	1.0	-1.1	1.0	-1.3	-0.5	0.3	-0.5
Light reinforcement 2	0.0	0.1	0.2	-0.2	0.0	-0.2	0.2	0.0	0.1	-0.4	-0.2	0.3	-0.3	-0.2	0.2	-0.5
Bone: marrow area	0.0	0.0	0.1	0.0	0.0	-0.0	-0.0	-0.3	-0.3	0.0	0.1	-0.1	0.2	0.0	-0.2	0.2
Bone: maximum diameter	0.5	1.0	2.4	1.2	0.7	1.6	-0.9	1.0	1.0	-0.3	1.3	-1.3	-0.2	1.0	-1.2	0.1
Bone: maximum force	1.1	2.0	3.7	1.0	1.6	1.9	-0.3	1.7	1.7	0.5	1.8	-1.6	-0.5	1.7	-1.8	0.5
Bone: maximum moment	1.1	1.9	3.8	1.1	1.4	1.9	0.0	1.7	1.7	0.1	1.9	-1.4	-0.7	1.7	-1.6	0.3
Mean time between licks in bursts	0.1	0.2	0.6	-0.2	0.8	0.5	-0.0	0.3	0.3	0.7	0.0	0.1	-0.0	0.7	-0.1	0.1
Mean num. licks in bursts	0.8	1.2	5.7	0.9	-2.0	-0.5	0.1	-0.2	-0.2	-2.4	-0.7	0.6	0.1	-0.8	1.5	-0.8
Cd content in liver	1.5	1.6	4.1	0.6	1.3	1.6	0.0	2.0	2.0	0.4	0.9	-0.8	-1.7	1.6	-1.1	0.6
Co content in liver	1.8	2.0	7.7	-2.1	2.8	0.1	-2.1	-0.0	-0.0	2.4	-1.2	0.0	-0.8	-1.1	-0.7	-0.5
Cu content in liver	0.7	0.8	5.2	0.3	-1.0	0.0	2.3	0.8	0.8	-0.5	0.2	0.6	-0.8	1.2	0.6	0.4
Fe content in liver	1.1	1.4	4.1	1.7	-1.5	-0.6	-0.6	-0.8	-0.8	-0.6	0.7	-1.3	2.0	0.1	-0.8	1.9
K content in liver	0.6	0.6	2.3	0.6	-1.5	0.0	1.5	0.1	0.1	-1.0	0.0	0.5	-0.2	0.6	0.9	-0.1
Mg content in liver	0.3	0.3	1.6	-0.3	-0.6	0.1	1.3	0.1	0.1	-0.0	-0.4	0.8	-0.5	0.5	0.7	-0.3
Mn content in liver	0.5	0.6	2.4	1.0	-0.8	1.0	-0.2	0.6	0.6	-1.6	-0.2	0.2	-0.4	0.6	0.7	-0.7
Na content in liver	0.3	0.3	1.8	0.5	-1.0	0.0	1.3	0.0	0.0	-0.6	0.7	0.1	0.3	0.5	0.1	-0.0
Rb content in liver	0.3	0.3	1.0	-0.5	0.2	-0.7	1.0	-0.3	-0.3	0.9	-0.1	-0.1	0.7	-0.0	-0.4	0.6
Se content in liver	0.3	0.4	1.2	0.7	-1.1	-0.4	-0.9	-0.5	-0.5	-0.6	-0.5	-0.2	0.9	-0.4	0.3	0.7
Sr content in liver	0.7	0.6	2.3	0.3	-1.2	-0.1	-0.4	-0.0	-0.0	-1.5	-0.8	0.6	-0.3	-0.6	1.1	-1.0
Zn content in liver	6.2	6.8	33.5	2.0	-3.5	0.7	5.8	1.9	1.9	-2.1	1.6	1.1	-2.1	4.0	1.5	0.9
Bone: minimum diameter	0.8	1.5	5.7	0.1	2.4	1.6	-1.8	1.3	1.3	0.4	0.5	-1.1	-0.8	0.2	-1.4	-0.4
Time in familiar zone, hab. session 1	0.5	0.4	1.2	-0.1	0.5	-0.2	-0.5	-0.2	-0.2	1.1	0.5	-0.8	0.8	-0.1	-1.0	1.1
Time in novel zone, hab. session 1	0.3	0.3	1.3	0.6	-0.7	0.2	0.4	0.3	0.3	-1.1	0.1	0.0	-0.4	0.1	0.2	-1.2
Total zone transitions, hab. session 1	2.8	3.9	10.1	-3.2	1.5	-2.2	-0.8	-2.1	-2.1	2.9	-2.8	1.3	0.8	-2.5	0.5	0.3
Total locomotion distance, hab. session 1	0.7	1.0	3.0	-1.7	0.7	-1.1	0.6	-1.0	-1.0	1.7	-1.2	0.8	0.4	-0.7	0.1	0.2
Locomotion velocity, hab. session 1	0.6	0.8	2.6	-1.6	0.8	-0.8	0.7	-0.9	-0.9	1.3	-1.2	1.0	-0.0	-0.5	0.4	0.2
Time in familiar zone, hab. session 2	1.3	1.3	4.1	1.9	-0.5	1.7	-0.7	1.2	1.2	-2.0	1.2	-0.9	-0.4	0.9	-0.2	-0.6
Time in novel zone, hab. session 2	1.1	1.1	2.8	-1.7	0.2	-1.7	1.0	-0.9	-0.9	1.6	-1.1	1.0	0.2	-0.7	0.4	0.6
Total zone transitions, hab. session 2	1.7	2.2	6.1	-2.5	1.5	-1.3	-1.0	-1.2	-1.2	2.5	-2.1	1.0	0.2	-1.5	0.3	0.1
Total locomotion distance, hab. session 2	0.4	0.5	1.5	-1.2	0.6	-0.3	-0.0	-0.3	-0.3	0.7	-1.1	1.0	-0.7	-0.4	0.6	-0.5
Locomotion velocity, hab. session 2	0.4	0.5	1.7	-1.3	0.4	-0.6	0.2	-0.5	-0.5	0.7	-1.1	1.1	-0.5	-0.4	0.7	-0.4
Novel to familiar place preference ratio	0.4	0.4	1.4	-0.9	0.2	-0.4	0.5	0.2	0.2	0.2	-0.9	1.0	-1.2	-0.4	0.8	-0.5
Novelty place preference	0.6	0.7	2.2	-1.0	0.1	-0.4	0.7	0.3	0.3	-0.0	-1.0	1.3	-1.5	-0.5	1.1	-0.8
Time in novel zone, NPP test	0.6	0.7	2.4	-0.9	0.0	-0.3	0.6	0.4	0.4	-0.2	-1.0	1.2	-1.5	-0.4	1.1	-0.8
Total zone transitions, NPP test	1.2	1.8	5.2	-2.3	1.9	-0.5	-1.0	-1.0	-1.0	2.1	-2.0	1.0	-0.2	-1.3	0.4	-0.2
Total locomotion distance, NPP test	0.2	0.3	1.2	-0.7	1.1	0.5	0.2	0.3	0.3	0.7	-0.3	0.4	-0.9	0.5	0.0	0.0
Locomotion velocity, NPP test	0.3	0.4	1.3	-0.7	1.1	0.7	0.2	0.4	0.5	0.6	-0.3	0.5	-1.1	0.6	0.1	-0.3
Intraocular pressure	0.5	0.7	2.1	1.1	-0.2	0.1	-1.1	-0.4	-0.4	-0.3	1.1	-1.5	0.9	-0.1	-1.1	0.5
Delta distance traveled before/after self-admin	0.9	1.0	2.7	-1.6	0.5	-0.4	1.3	0.5	0.5	0.8	-1.0	1.4	-1.6	-0.1	0.7	-1.1
Delta ambulatory time before/after self-admin	0.7	0.9	2.9	-1.2	0.6	-0.0	1.4	0.9	0.9	0.5	-0.6	1.1	-1.7	0.4	0.5	-1.0
Parametrial fat weight	0.4	0.9	1.6	1.0	0.0	0.9	0.6	1.3	1.2	-0.0	1.2	-1.0	-0.6	1.3	-1.0	0.8
Pavlov. Cond. lever latency	0.2	0.3	1.3	-0.4	0.7	0.4	-1.1	0.3	0.3	-0.0	-0.4	0.0	-0.7	-0.5	0.0	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	-0.6	0.1	-0.9	0.0	-0.7	-0.7	0.6	-0.8	0.1	0.4	-0.8	-0.1	0.6
Pavlov. Cond. change in total contacts	1.1	1.1	2.5	-1.5	-0.3	-1.6	0.7	-1.2	-1.2	1.2	-1.2	1.3	0.5	-0.8	0.9	0.6
Pavlov. Cond. index score	0.1	0.1	0.6	0.2	-0.6	-0.4	0.8	-0.2	-0.2	-0.2	-0.1	0.2	0.2	0.2	0.2	0.6
Pavlov. Cond. latency score	0.2	0.2	1.0	0.2	-0.8	-0.5	1.0	-0.3	-0.3	-0.2	0.0	0.2	0.4	0.3	0.2	0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.7	-0.3	0.3	0.6	0.3	0.3	-0.1	0.7	-0.4	0.4	0.9	-0.3	0.9
Pavlov. Cond. magazine entry number	0.4	0.4	1.3	1.0	-0.7	0.8	0.1	0.5	0.5	-1.1	0.8	-0.2	-0.0	0.8	0.2	-0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.9	0.5	0.2	0.1	-0.4	0.3	0.3	0.4	0.5	-0.5	0.3	0.7	-0.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.2	-0.0	-0.8	-0.5	1.1	-0.3	-0.3	-0.4	-0.4	0.6	-0.0	0.1	0.7	0.3
Pavlov. Cond. response bias	0.3	0.4	1.9	-0.4	0.5	-0.5	0.1	-0.4	-0.4	1.1	0.0	-0.3	0.6	-0.1	-0.7	1.4
Pavlov. Cond. lever latency	0.5	0.7	2.3	-0.1	-1.5	-1.0	0.1	-1.0	-1.1	-0.5	-0.6	0.7	1.0	-0.8	1.2	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	-0.6	-0.4	0.1	-0.3	-0.3	-0.3	-0.0	-0.1	0.3	-0.1	-0.0	0.0
Pavlov. Cond. change in total contacts	0.3	0.5	1.2	0.4	0.5	0.8	0.4	1.1	1.1	-0.1	0.5	-0.4	-0.9	1.0	-0.6	0.1
Pavlov. Cond. index score	0.4	0.6	1.3	1.1	0.0	0.7	-0.1	0.7	0.8	-0.4	1.0	-1.1	-0.0	0.8	-1.0	0.5
Pavlov. Cond. latency score	0.3	0.4	1.0	1.0	-0.2	0.5	0.2	0.5	0.6	-0.3	0.9	-0.9	0.0	0.9	-0.8	0.6
Pavlov. Cond. lever contacts	0.7	1.0	2.2	0.5	1.5	1.2	-0.5	1.1	1.2	0.2	0.8	-1.1	-0.8	0.9	-1.4	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.8	-0.9	0.3	-0.1	0.3	-0.2	-0.2	0.3	-0.5	0.8	-0.3	-0.3	0.6	-0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.9	2.2	0.9	0.2	1.4	0.4	1.3	1.3	-1.1	0.9	-0.4	-1.5	1.0	-0.3	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.4	1.2	-0.0	0.7	-0.1	0.7	0.8	-0.4	1.0	-1.2	0.0	0.9	-1.0	0.6
Pavlov. Cond. response bias	0.4	0.6	1.6	0.3	1.3	0.9	-0.7	0.8	0.9	0.2	0.5	-1.0	-0.4	0.4	-1.2	0.2
Time in closed arm before self-admin	0.2	0.3	1.9	-0.1	0.2	0.2	0.3	0.3	0.1	0.7	0.1	-0.1	0.1	0.7	-0.3	1.4
Time in closed arm after self-admin	0.4	0.4	1.3	-0.2	0.3	0.3	1.0	0.8	0.6	0.5	0.3	0.4	-1.0	1.2	-0.1	0.3
Time in open arm before self-admin	1.3	1.4	6.4	0.6	-0.1	1.5	-0.0	1.0	1.1	-1.6	0.2	0.3	-1.8	0.3	0.7	-2.5
Time in open arm after self-admin	0.3	0.3	1.3	-0.2	0.2	-0.8	-0.3	-0.8	-0.6	-0.1	-0.4	-0.2	0.8	-1.2	-0.0	-0.5
Bone: periosteal estimation	0.6	1.2	2.8	0.9	1.3	1.7	-1.4	1.1	1.1	-0.2	1.1	-1.3	-0.4	0.7	-1.3	-0.1
Bone: periosteal perimeter	0.6	1.0	3.2	0.7	1.3	1.3	-1.8	0.7	0.7	0.2	0.9	-1.4	0.0	0.2	-1.5	-0.1
Bone: post-yield work	0.6	0.8	2.4	-0.1	0.0	-0.5	1.4	-0.5	-0.5	1.3	1.1	-0.5	1.1	0.9	-1.0	1.6
Progressive ratio test 1 active lever presses	1.5	1.8	6.7	-2.6	1.7	-0.6	-0.1	0.1	-0.0	1.2	-2.0	1.6	-1.1	-1.5	0.8	-1.2
Progressive ratio test 1 breakpoint	1.4	1.7	6.4	-2.5	1.7	-0.5	-0.1	0.3	0.1	1.3	-1.8	1.6	-1.2	-1.3	0.8	-1.2
Progressive ratio test 1 inactive lever presses	1.2	1.7	4.3	-1.5	-0.4	-1.3	0.5	-1.0	-0.9	-0.5	-2.1	2.1	0.1	-1.5	1.9	-1.1
Progressive ratio test 2 active lever presses	0.5	0.5	2.4	-0.8	1.6	0.5	-0.7	0.5	0.3	0.6	-0.3	-0.1	-1.1	-0.6	-0.5	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	1.9	-0.7	1.4	0.6	-0.4	0.6	0.4	0.4	-0.3	-0.0	-1.2	-0.5	-0.3	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.9	-0.7	0.6	-0.5	-0.6	-0.8	-0.8	0.9	-0.7	-0.1	0.3	-0.9	-0.4	0.1
Incentive Sensitization - Responses	0.5	0.7	2.6	1.1	-0.1	0.2	-0.7	-0.5	-0.4	0.3	0.9	-1.6	0.7	0.2	-1.3	1.3
Incentive Sensitization - Breakpoint	0.6	0.8	2.8	1.3	-0.2	0.4	-0.7	-0.3	-0.2	0.0	1.0	-1.7	0.6	0.3	-1.3	1.1
Sum of active levers in priming session hrs 5-6	1.6	1.5	3.6	1.6	-0.9	1.5	0.9	1.5	1.5	-1.9	1.0	-0.1	-1.0	1.6	0.6	-0.4
Progressive ratio	0.5	0.8	4.4	1.0	-0.4	0.6	-1.0	-0.2	-0.2	-1.5	0.2	-0.6	-0.4	-0.6	0.2	-2.1
Food seeking constrained by brief footshock	1.5	1.8	4.6	0.8	1.4	2.2	-0.4	1.7	1.9	-0.1	1.4	-1.2	-1.8	1.3	-1.3	-0.5
Seeking ratio, punishment vs. effort	0.4	0.5	1.0	-1.0	0.7	0.3	0.9	0.7	0.8	1.0	-0.1	0.6	-1.0	0.7	-0.0	0.8
Retroperitoneal fat weight	0.4	1.9	4.6	1.2	1.1	1.9	-0.5	2.1	2.1	-0.8	1.5	-1.3	-1.3	1.0	-1.1	-0.4
Reaction time number correct	0.2	0.4	2.2	-0.3	0.2	0.5	0.9	0.3	0.3	-0.5	0.0	0.4	-0.9	-0.0	0.3	-1.5
Reaction time mean minus median	0.4	1.0	3.5	1.1	-1.0	-0.4	-1.6	-0.9	-0.9	-0.5	0.4	-0.9	1.9	-0.4	-0.3	1.1
Reaction time mean minus median AUC	0.2	0.6	1.7	0.9	-1.1	-0.6	-0.8	-0.7	-0.7	-0.7	0.3	-0.4	1.3	-0.4	0.1	0.9
Reaction time num false alarms	1.7	2.4	5.4	-1.7	-0.2	-2.2	-0.5	-2.2	-2.3	1.4	-1.6	0.7	1.6	-2.2	0.4	-0.2
Reaction time num false alarms AUC	1.4	2.3	5.2	-1.4	0.1	-1.9	-1.2	-2.2	-2.3	1.4	-1.3	0.2	1.9	-2.2	-0.0	0.0
Reaction time trials correct on left	0.2	0.4	2.2	-0.3	0.2	0.5	0.9	0.3	0.3	-0.5	0.0	0.4	-0.9	-0.0	0.3	-1.5
Reaction time trials on left	0.2	0.3	2.2	-0.2	0.1	0.4	0.8	0.2	0.2	-0.5	0.0	0.4	-0.8	-0.1	0.4	-1.5
Reaction time mean	0.6	0.9	2.2	0.8	-1.4	-0.4	-1.4	-0.9	-0.8	-1.5	-0.2	0.1	1.4	-0.8	0.8	-0.4
Reaction time mean AUC	0.6	1.0	2.2	0.6	-1.3	-0.5	-1.5	-1.0	-0.9	-1.5	-0.4	0.3	1.4	-1.1	1.0	-0.6
Median of all reaction times	0.5	0.8	2.5	0.5	-1.1	-0.2	-1.1	-0.6	-0.6	-1.6	-0.4	0.5	0.9	-0.8	1.0	-1.0
Reaction time omissions	1.2	1.8	5.2	1.6	-2.2	-0.7	-1.6	-1.4	-1.5	-1.1	0.4	-1.0	2.3	-0.8	0.1	0.5
Reaction time false alarm rate	1.1	1.6	3.4	-0.9	-0.2	-1.7	-1.1	-1.8	-1.9	1.2	-1.1	0.0	1.8	-1.6	-0.1	0.6
Reaction time premature initiation rate	0.3	0.4	1.8	-0.7	1.3	-0.2	-0.9	0.0	0.0	0.8	-0.4	-0.3	-0.3	-0.7	-0.8	0.2
Reaction time premature initiations	0.3	0.5	2.3	-0.9	1.5	0.0	-0.9	-0.1	-0.1	0.7	-0.3	-0.2	-0.4	-0.9	-0.7	-0.7
Std. dev. reaction times	0.6	1.1	3.5	1.4	-1.6	-0.5	-1.4	-1.0	-0.9	-0.8	0.4	-0.9	1.9	-0.4	-0.1	0.8
Reaction time trials completed	0.2	0.3	2.2	-0.2	0.1	0.4	0.8	0.2	0.2	-0.5	0.0	0.4	-0.8	-0.1	0.4	-1.5
Reaction time trials AUC	0.1	0.3	1.7	-0.2	0.3	0.6	0.7	0.4	0.4	-0.4	0.2	0.2	-0.8	0.1	0.2	-1.3
Run reversals in cocaine runway, females	1.0	1.0	2.8	-0.8	-0.5	-0.3	1.7	-0.0	0.3	-0.8	-0.8	1.5	-0.8	-0.2	1.5	-1.6
Run reversals in cocaine runway, males	1.4	1.4	3.4	-1.5	-0.4	-0.5	0.7	-0.3	-0.3	-0.4	-1.7	1.8	-1.4	-1.1	1.7	-1.7
Latency to leave start box in cocaine runway	0.6	0.7	2.5	-0.7	-0.7	-0.6	1.6	-0.3	-0.1	-0.1	-0.9	1.3	-0.7	0.1	1.2	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.8	-0.7	0.3	-0.4	0.5	-0.2	-0.3	0.9	-0.4	0.4	0.1	0.2	0.0	0.5
Latency to leave start box in cocaine runway, M	1.4	1.3	4.3	0.2	-1.6	-0.1	2.1	0.2	0.7	-1.5	-0.6	1.4	-1.5	0.4	1.6	-0.7
Std. dev. time between licks in bursts	1.1	1.5	5.1	-2.3	0.7	-1.0	1.6	-0.4	-0.3	1.7	-1.6	1.9	-0.5	-0.1	1.1	0.1
Total sessions with >9 infusions	1.9	2.3	8.5	-2.9	1.3	-1.5	0.1	-0.6	-0.7	2.5	-2.2	1.6	0.1	-1.5	0.8	0.1
Short access day 1 total inactive lever presses	0.6	0.8	2.8	-1.7	0.9	-0.5	0.5	-0.2	-0.1	1.4	-1.4	1.2	-0.4	-0.2	0.7	0.2
Short access day 10 total inactive lever presses	0.6	1.5	3.4	-0.5	-1.5	-1.8	1.0	-1.8	-1.8	-0.1	-1.2	1.2	1.2	-0.9	1.3	-0.3
Short access day 1 total infusions	1.2	1.6	6.4	-2.0	1.2	-1.3	-0.3	-0.8	-0.9	2.5	-1.4	0.6	0.8	-1.0	-0.1	1.1
Short access day 10 total infusions	1.7	2.2	7.3	-2.7	0.7	-1.6	1.0	-0.4	-0.7	1.2	-2.2	2.3	-0.3	-1.4	1.6	-0.1
Short access total infusions	1.8	2.2	8.0	-2.8	1.1	-1.4	0.5	-0.5	-0.7	1.7	-2.3	2.0	-0.4	-1.5	1.3	-0.6
Short access day 1 locomotion	1.0	1.2	6.7	-1.8	1.5	-0.8	-0.1	-0.4	-0.3	2.6	-1.0	0.5	0.1	-0.2	-0.3	1.1
Short access day 10 total locomotion	0.1	0.2	0.5	-0.6	0.2	-0.1	0.2	0.5	0.7	0.2	-0.4	0.7	-0.3	0.3	0.6	0.0
Short access total locomotion	0.4	0.5	1.5	-1.2	0.1	-0.7	0.7	0.1	0.2	0.7	-1.0	1.2	-0.2	-0.1	1.0	0.0
One hour access (0.3 mA shock)	0.4	0.4	1.4	0.5	0.2	0.9	-0.2	1.2	1.1	-0.3	0.3	-0.5	-0.9	0.6	-0.3	0.2
Compulsive drug intake	0.4	0.5	1.7	1.3	-0.5	1.1	-0.4	0.4	0.6	-1.3	0.8	-0.5	0.0	0.8	-0.0	0.3
One hour access (shock baseline)	0.1	0.2	0.9	-0.6	0.3	-0.1	0.4	0.6	0.3	0.0	-0.5	0.4	-0.9	-0.4	0.2	-0.6
Social response proportion	0.3	0.4	1.4	0.1	-1.2	-0.5	0.1	-1.0	-0.9	-0.3	-0.0	0.1	1.0	-0.5	0.3	-0.2
Social responses	0.7	0.8	1.8	1.1	-0.8	1.3	0.5	1.1	1.2	-1.3	0.8	-0.2	-0.7	1.1	0.1	-0.5
Social time	0.9	1.2	3.6	1.9	-1.7	0.1	0.4	-0.2	-0.2	-1.1	1.4	-1.0	1.4	1.0	-0.3	1.2
Soleus weight	0.2	0.7	4.1	-0.1	1.4	0.5	-2.0	0.3	0.3	0.2	0.3	-0.8	-0.1	-0.8	-0.8	-0.3
Bone: stiffness	0.6	0.9	2.3	0.4	1.3	1.5	-0.3	1.3	1.3	0.3	1.0	-0.8	-0.6	1.1	-1.0	0.1
Tibialis anterior weight	2.0	6.9	31.8	1.1	3.7	3.4	-5.6	2.2	2.2	-0.5	1.3	-2.7	-1.4	-0.7	-2.4	-2.0
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.1	-0.6	-0.6	-1.3	1.0	-1.5	-1.3	0.5	-0.6	0.5	1.2	-0.7	0.4	0.5
Time to tail flick, vehicle, after self-admin	1.6	2.1	7.3	1.8	-0.7	0.1	-2.2	-1.3	-1.0	-0.1	1.0	-2.0	2.7	-0.0	-1.3	1.6
Time to tail flick, test, before self-admin	0.4	0.4	1.1	1.0	-1.0	-0.7	0.0	-0.4	-0.4	-0.8	0.2	-0.4	1.0	0.0	0.1	1.0
Time to tail flick, test, after self-admin	0.3	0.4	1.0	0.6	0.4	0.2	-0.8	-0.4	-0.4	0.5	0.4	-0.8	1.0	0.4	-0.7	0.6
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	6.0	0.8	0.3	0.9	-2.5	-0.3	-0.1	0.4	0.5	-1.3	1.0	0.1	-0.8	0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	1.5	-0.3	1.2	0.8	-0.5	0.2	0.3	1.1	0.3	-0.6	-0.5	0.3	-0.9	-0.1
Tibia length	0.7	1.8	3.4	1.6	0.8	1.9	-1.3	1.6	1.6	-1.4	1.7	-1.6	-0.6	0.6	-1.3	-0.5
Ambulatory time before self-admin	0.5	0.7	3.2	0.6	-0.0	-0.2	-1.1	-0.9	-0.9	0.2	-0.1	-0.8	1.8	-0.4	-0.3	1.3
Ambulatory time after self-admin	0.4	0.4	1.9	-0.3	0.2	-0.7	0.2	-0.6	-0.5	1.1	-0.3	-0.2	1.0	0.0	-0.3	1.4
Bone: tissue strength	2.1	2.1	4.4	0.8	1.5	2.0	0.3	1.8	1.7	0.4	2.1	-1.3	-1.5	1.8	-1.7	-0.1
Total heroin consumption	0.9	1.0	2.4	1.6	-0.1	1.1	-0.7	1.3	1.2	-0.7	1.1	-1.2	0.0	1.1	-0.7	0.9
Bone: trabecular number	0.4	0.7	2.3	1.0	-1.1	-0.6	-0.5	-0.7	-0.7	-0.1	0.5	-0.9	1.5	0.0	-0.5	1.4
Bone: trabecular spacing	0.8	1.1	2.3	0.6	-0.3	1.3	0.8	1.4	1.4	-1.5	0.5	0.5	-1.5	1.1	0.7	-1.0
Bone: trabecular thickness	0.3	0.4	1.2	-0.6	0.1	-0.6	-0.8	-0.9	-0.9	0.5	-0.6	0.1	0.6	-1.1	0.2	-0.3
Bone: trabecular tissue density	0.7	1.0	2.2	-1.2	0.1	-0.8	-0.4	-1.4	-1.4	0.5	-1.5	0.9	0.8	-1.4	0.8	-0.7
Water consumed over 24 hours	0.2	0.3	1.0	-0.5	0.8	0.6	-0.6	0.4	0.3	0.5	-0.5	0.0	-1.0	-0.1	-0.0	-0.8
Number of responses in last shaping day	2.5	2.7	5.3	-2.3	1.3	-1.8	-1.3	-2.0	-1.9	2.1	-1.9	0.8	1.5	-2.2	0.2	0.4