Hub : Genes

Eif4e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS XM_063281173.1 0.04 0.02 3.6e-05 0.02 0.03 0.02 0.03 3.6e-04 1.1e-05 2.0e-04 1.2e-05
2 PL alternative TSS NM_053974.2 0.11 0.07 1.6e-05 0.04 0.04 0.04 0.04 5.3e-05 6.7e-05 8.9e-05 4.2e-05
3 Brain gene expression Eif4e 0.06 0.04 2.8e-04 0.02 0.04 0.03 0.03 4.7e-03 1.8e-04 1.5e-03 1.3e-03
4 NAcc isoform ratio XM_063281174.1 0.04 0.03 2.7e-03 0.03 0.01 0.02 0.03 8.8e-05 1.8e-03 2.0e-04 8.6e-05
5 PL gene expression Eif4e 0.04 0.02 1.4e-03 0.03 0.02 0.01 0.02 4.3e-04 2.7e-03 1.4e-02 3.2e-03
6 BLA gene expression Eif4e 0.08 0.05 6.0e-03 0.03 0.02 0.02 0.02 1.5e-02 1.9e-02 4.1e-02 3.1e-02
7 IC alternative TSS NM_053974.2 0.21 0.1 3.2e-04 -0.01 0.05 0.03 0 8.9e-01 4.9e-03 1.9e-02 2.2e-01
8 Adipose gene expression Eif4e 0.03 0.02 7.2e-03 -0 -0 0 -0 5.7e-01 3.8e-01 3.4e-01 7.6e-01
9 NAcc alternative TSS XM_063281175.1 0.05 0.03 1.1e-06 0.05 0.05 0.04 0.04 1.3e-07 8.4e-08 2.5e-07 2.6e-07
10 OFC intron excision ratio chr2_229762590_229765229 0.29 0.12 2.4e-04 0.13 0.03 0.03 0.1 6.3e-04 6.0e-02 5.4e-02 3.0e-03
11 NAcc gene expression Eif4e 0.09 0.04 3.9e-12 0.07 0.09 0.08 0.08 7.5e-11 3.8e-13 3.2e-12 1.0e-11
12 PL isoform ratio XM_063281174.1 0.04 0.03 4.5e-03 0 0.02 0.01 0.01 1.6e-01 6.6e-03 6.3e-02 5.4e-02
13 LHb intron excision ratio chr2_229740783_229761142 0.24 0.12 4.1e-03 0.02 0.07 0.07 0.04 8.9e-02 8.5e-03 7.5e-03 4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.51.03.71.9-0.91.0-0.0-0.8-0.8-1.3-1.3-1.10.11.1-0.4-0.3
Area under the delay curve0.50.81.7-0.9-0.7-1.30.50.90.9-0.11.01.20.0-0.81.10.7
BMI with tail0.72.57.80.12.82.3-1.6-2.1-2.00.2-0.9-0.92.00.6-1.11.2
BMI without tail0.42.15.20.32.32.0-1.7-1.7-1.7-0.6-0.5-0.72.10.1-0.71.7
Body weight1.04.414.90.23.92.8-2.4-2.8-2.70.6-1.0-1.62.20.6-1.81.0
Weight adjusted by age0.51.53.5-1.9-0.1-1.30.90.50.70.31.51.90.3-1.21.51.6
Bone surface0.40.72.81.7-0.70.8-0.2-0.5-0.5-1.1-1.3-1.1-0.10.8-0.6-0.3
Bone volume0.40.93.21.8-0.60.9-0.8-0.4-0.4-1.1-1.3-1.4-0.50.6-0.8-0.3
Breakpoint value in progressive ratio session0.30.61.90.30.71.1-0.2-1.4-1.30.3-0.3-0.30.61.1-0.3-0.9
Number of licking bursts0.41.34.1-0.92.01.30.2-1.1-1.11.8-0.7-0.21.21.3-1.10.1
Context. condit. distance diff. score0.40.51.70.20.40.40.9-1.0-1.00.5-0.4-0.00.61.3-0.2-0.9
Locomotion velocity, session 11.31.44.5-2.11.2-0.8-0.60.90.91.31.51.00.3-1.60.41.5
Locomotion distance, session 12.22.910.5-3.21.6-1.30.21.31.32.52.31.80.6-1.60.80.9
Locomotion velocity, session 20.91.12.2-1.5-0.2-0.90.81.11.10.41.51.50.2-1.01.21.0
Locomotion distance, session 25.17.220.1-4.50.8-3.00.42.92.92.73.73.1-0.4-3.12.11.5
Locomotion velocity, session 31.01.14.5-1.51.8-0.6-1.00.80.72.10.7-0.1-0.8-0.8-0.8-0.5
Locomotion distance, session 30.20.20.8-0.80.3-0.4-0.00.30.30.90.40.4-0.1-0.20.0-0.0
Stereotopy head waving bouts, day 30.40.51.5-0.71.1-0.0-1.20.60.60.90.1-0.3-0.4-0.7-0.70.3
Stereotopy head waving duration, day 30.91.13.9-0.22.01.0-1.7-0.3-0.41.2-0.6-1.10.00.1-1.6-0.2
Locomotion velocity, session 70.70.82.5-1.51.20.20.5-0.2-0.31.10.40.81.2-0.20.21.6
Locomotion distance, session 70.81.13.2-1.80.9-0.21.1-0.4-0.41.31.11.51.30.10.90.8
Stereotopy head waving bouts, day 71.31.64.3-0.5-0.3-1.4-1.42.02.00.50.6-0.2-2.1-1.7-0.2-0.6
Stereotopy head waving duration, day 71.82.26.0-0.7-0.1-1.5-1.72.32.31.00.7-0.4-2.4-1.9-0.4-0.7
Locomotion velocity, session 80.40.51.6-1.30.1-0.80.70.50.50.60.81.10.3-0.50.61.0
Locomotion distance, session 82.13.111.3-3.41.6-1.50.90.90.92.72.42.30.7-1.11.20.4
Degree of sensitization distance0.60.72.3-0.20.40.71.2-1.1-1.1-0.10.10.71.51.00.50.4
Degree of sensitization stereotypy1.41.54.5-0.0-0.8-1.4-1.41.91.9-0.10.5-0.2-2.1-1.60.1-0.7
Conditioned locomotion0.91.03.80.9-1.9-1.0-0.00.90.9-1.6-0.1-0.1-1.5-0.90.50.0
Cocaine response after cond. corrected0.10.20.80.3-0.40.10.10.10.1-0.9-0.4-0.1-0.4-0.30.20.9
Cocaine response after cond. not corrected0.60.93.40.3-1.4-0.20.80.30.3-1.90.00.8-0.4-0.51.31.6
Cocaine response before conditioning0.40.41.2-0.3-0.8-0.50.70.20.1-0.80.71.00.2-0.31.10.9
Saline control response1.72.34.8-1.70.3-2.1-0.22.22.11.41.90.9-1.9-1.70.3-0.9
Bone: connectivity density0.50.71.91.4-1.40.31.0-0.6-0.6-0.9-0.9-0.40.11.20.1-0.8
Bone: cortical apparent density0.10.20.5-0.30.60.5-0.4-0.5-0.50.40.30.10.70.2-0.10.2
Bone: cortical area2.33.78.71.91.93.0-1.9-2.3-2.3-0.6-2.1-2.31.01.6-2.10.2
Bone: cortical porosity0.30.41.1-0.90.7-0.4-0.50.60.60.50.50.3-0.3-1.00.10.6
Bone: cortical porosity0.30.41.1-0.91.1-0.2-0.70.40.40.50.50.1-0.0-1.0-0.10.6
Bone: cortical thickness2.74.510.72.22.03.3-2.0-2.7-2.7-0.7-2.4-2.41.11.9-2.10.1
Bone: cortical thickness0.91.12.61.20.41.5-0.9-1.4-1.4-1.6-0.8-0.80.60.4-0.31.0
Bone: cortical tissue density0.10.20.5-0.40.70.4-0.4-0.5-0.50.50.40.20.70.2-0.10.1
Condit. Reinf. active minus inactive responses1.21.45.5-2.12.3-0.0-0.70.10.12.10.80.71.0-0.5-0.30.8
Condit. Reinf. active-inactive response ratio2.42.613.2-1.63.61.4-1.4-1.2-1.22.4-0.1-0.31.70.3-1.40.8
Condit. Reinf. active responses1.51.95.5-2.30.7-1.5-0.01.51.51.51.81.7-0.1-1.41.00.4
Condit. Reinf. inactive responses2.02.65.2-0.4-2.3-2.20.42.32.3-0.81.51.3-1.8-1.51.7-0.7
Incentive salience index mean0.50.63.4-1.21.90.3-0.3-0.2-0.21.30.20.40.90.0-0.40.6
Condit. Reinf. lever presses0.20.20.70.50.60.5-0.2-0.2-0.10.1-0.8-0.7-0.20.6-0.8-0.4
Condit. Reinf. active minus inactive responses1.21.83.91.90.41.8-0.2-1.2-1.2-0.8-2.0-1.90.51.5-1.8-0.2
Condit. Reinf. active-inactive response ratio1.72.75.31.91.02.3-0.4-1.7-1.7-0.2-2.2-2.10.82.1-2.1-0.6
Condit. Reinf. active responses0.81.22.31.40.41.5-0.1-1.2-1.2-1.0-1.5-1.30.81.1-1.20.3
Condit. Reinf. inactive responses0.10.20.3-0.60.3-0.30.3-0.3-0.3-0.20.40.50.5-0.50.20.5
Condit. Reinf. lever presses0.60.91.91.20.01.10.6-1.3-1.3-1.4-0.8-0.41.11.2-0.3-0.1
Condit. Reinf. lever reinforcers received0.71.01.91.40.11.4-0.1-1.2-1.1-1.1-1.3-1.10.91.0-1.00.3
Conditioned reinforcement - actives0.52.07.9-1.11.1-1.4-0.71.01.12.80.4-0.7-1.7-0.8-1.3-2.5
Conditioned reinforcement - inactives0.41.02.4-0.8-0.3-1.60.21.41.40.71.60.8-0.9-1.00.7-0.4
Conditioned locomotion0.91.38.90.8-1.1-1.10.70.50.40.6-0.4-0.8-1.50.5-0.6-3.0
Patch foraging indifference point 0 sec0.20.63.3-0.7-0.4-1.01.80.10.20.60.51.00.20.30.7-0.8
Patch foraging indifference point AUC0.51.22.91.00.81.7-0.4-1.2-1.4-0.1-1.2-1.10.71.4-1.1-0.6
Delay disc. indifference point, 0s delay0.30.30.70.7-0.5-0.30.20.00.30.1-0.8-0.6-0.30.7-0.7-0.7
Delay disc. indifference point, 16s delay0.20.30.8-0.90.4-0.50.10.40.40.70.80.60.4-0.40.40.4
Delay disc. indifference point, 2s delay0.60.72.70.9-1.7-0.9-0.20.91.1-0.8-0.4-0.4-1.0-0.30.1-0.3
Delay disc. indifference point, 24s delay0.60.91.9-0.2-1.1-1.20.71.01.1-0.90.81.1-0.6-0.71.40.8
Delay disc. indifference point, 4s delay0.60.61.5-0.4-1.0-0.50.90.1-0.0-0.80.61.20.9-0.11.20.8
Delay disc. indifference point, 8s delay1.72.85.5-2.3-0.2-2.30.21.92.00.72.32.0-0.6-2.21.60.8
Indifference point function ln k0.51.65.0-2.20.7-1.30.80.91.11.21.81.70.1-1.21.10.7
Indifference point function log k0.51.65.0-2.20.7-1.30.80.91.11.21.81.70.1-1.21.10.7
Patch foraging total patch changes 0 sec0.20.63.4-0.8-0.3-1.01.8-0.00.00.70.61.00.30.30.7-0.9
Patch foraging total patch changes 12 sec0.30.41.20.10.50.51.1-0.9-1.0-0.1-0.30.30.80.90.1-0.4
Patch foraging total patch changes 18 sec0.30.61.9-0.40.60.11.4-0.8-0.90.9-0.20.31.11.0-0.1-0.9
Patch foraging total patch changes 24 sec0.10.52.0-0.71.0-0.30.3-0.1-0.11.4-0.0-0.10.30.2-0.7-1.3
Patch foraging total patch changes 6 sec1.42.46.51.20.31.61.5-2.4-2.4-0.4-1.3-0.31.82.5-0.4-1.3
Patch foraging time to switch 0 sec0.10.40.80.4-0.9-0.7-0.60.80.9-0.3-0.1-0.3-0.8-0.70.20.5
Patch foraging water rate 0 sec0.10.51.20.40.81.10.3-0.9-1.10.1-0.6-0.40.61.1-0.6-0.7
Patch foraging water rate 12 sec0.10.63.0-0.71.70.8-0.7-0.8-0.80.80.1-0.10.8-0.0-0.60.3
Patch foraging water rate 18 sec1.02.36.00.91.22.4-0.1-2.1-2.2-0.3-1.8-0.91.81.9-1.20.2
Patch foraging water rate 24 sec0.81.12.6-0.61.51.40.3-1.4-1.51.0-0.4-0.01.61.1-0.70.5
Patch foraging water rate 6 sec1.31.96.5-2.12.61.1-0.0-0.9-1.11.21.11.22.2-0.10.21.2
Seeking ratio, delayed vs. immediate footshock1.21.76.40.6-2.5-1.51.30.91.2-1.80.81.0-0.7-0.61.80.1
Distance traveled before self-admin0.40.93.11.10.00.3-1.10.50.40.2-0.7-1.4-1.60.1-1.0-1.8
Distance traveled after self-admin0.00.10.4-0.20.20.1-0.10.0-0.10.70.2-0.1-0.00.2-0.2-0.7
Extensor digitorum longus weight1.76.830.21.04.23.1-5.5-1.9-1.90.3-1.3-3.20.9-0.8-3.01.0
Bone: elastic displacement0.81.02.20.81.21.5-1.2-1.1-1.1-0.1-1.1-1.20.50.6-1.20.3
Bone: elastic work2.53.27.81.41.92.8-1.3-2.3-2.3-0.5-2.2-1.81.51.5-1.80.9
Bone: endosteal estimation0.00.00.10.00.10.0-0.10.20.20.1-0.2-0.1-0.20.0-0.3-0.2
Bone: endosteal perimeter0.20.41.40.20.80.5-1.20.10.10.6-0.4-0.9-0.40.1-1.1-0.2
Epididymis fat weight0.21.23.6-0.01.91.5-0.6-1.4-1.40.7-1.0-1.01.00.6-1.30.3
Delta time in closed arm before/after self-admin0.70.72.2-1.50.8-0.9-0.31.00.91.40.60.5-0.2-0.9-0.3-0.1
Delta time in open arm before/after self-admin0.91.13.2-0.60.6-1.5-0.41.31.31.00.6-0.3-1.8-1.4-0.5-0.8
Diff in mean of infusions in LGA sessions0.61.24.3-0.2-0.50.72.1-1.1-1.3-0.60.01.11.71.20.90.7
Delay discount exponential model param0.70.92.00.90.81.3-0.6-0.8-0.90.3-1.2-1.4-0.10.9-1.4-0.8
Extinction: sum of active levers before priming0.91.33.50.80.41.4-0.2-1.8-1.7-1.2-0.2-0.11.80.60.41.9
Active lever presses in extinction session 60.50.53.0-0.3-0.6-0.31.7-0.4-0.40.50.20.50.40.70.4-0.9
Bone: final force0.61.02.20.51.21.5-0.3-1.5-1.50.1-0.9-0.81.01.2-1.0-0.1
Bone: final moment0.71.12.40.71.11.6-0.1-1.5-1.5-0.2-1.0-0.71.11.3-0.90.1
Food consumed during 24 hour testing period0.40.82.5-1.41.30.3-0.2-0.2-0.20.61.40.81.6-0.80.41.0
Glucose0.61.03.3-0.51.21.30.4-1.2-1.2-0.30.10.61.80.30.51.5
Heart weight0.81.22.51.01.31.5-1.2-1.0-1.1-0.3-1.6-1.50.00.6-1.50.1
Delay discount hyperbolic model param0.70.91.80.71.01.3-0.7-0.9-0.90.4-1.0-1.30.10.8-1.3-0.7
Intermittent access intake day 1-15 change0.00.21.10.5-1.1-0.40.10.60.7-0.4-0.0-0.3-0.5-0.30.1-0.4
Intermittent access intake escalation0.10.41.80.9-1.3-0.20.50.30.4-0.8-0.3-0.4-0.50.10.2-0.5
Intermittent access intake escalation 20.40.72.51.6-0.90.80.2-0.5-0.5-1.1-1.1-1.00.20.8-0.4-0.3
Intermitt. access day 1 inactive lever presses0.11.02.5-1.50.0-1.00.80.70.40.11.61.60.3-1.01.20.6
Intermitt. access day 15 inactive lever presses0.00.20.6-0.50.3-0.2-0.20.70.6-0.10.50.5-0.1-0.80.20.4
Intermitt. access escalation Index0.10.21.00.40.0-0.3-0.30.60.6-0.5-0.2-0.4-1.0-0.5-0.3-0.1
Intermittent access day 1 total infusions0.30.82.1-1.21.40.40.2-1.2-1.00.60.50.71.4-0.20.20.8
Intermittent access day 15 total infusions0.20.51.80.10.40.80.4-1.4-1.1-0.2-0.3-0.11.30.4-0.10.4
Intermittent access terminal intake (last 3 days)0.30.62.2-0.61.10.70.2-1.3-1.00.60.10.11.50.2-0.20.4
Intermittent access total infusions0.80.93.3-1.01.50.70.1-1.4-1.20.80.30.41.80.1-0.10.7
Intermittent access day 1 locomotion0.30.51.7-0.41.30.6-0.4-1.2-1.10.7-0.1-0.10.60.4-0.5-0.1
Intermittent access day 15 total locomotion0.10.61.51.0-0.50.70.1-0.8-0.7-0.1-0.8-1.00.10.9-0.7-1.2
Intermittent access total locomotion0.40.51.30.60.51.0-0.3-1.1-1.10.0-0.7-0.70.60.9-0.6-0.3
Intermittent access standard deviation0.21.02.60.90.61.4-1.6-1.2-1.3-0.0-0.9-1.30.60.7-1.0-0.0
Left kidney weight0.21.85.60.32.41.9-2.1-1.7-1.70.1-0.4-1.11.40.1-1.00.3
Right kidney weight0.32.15.80.52.42.0-2.4-1.7-1.60.3-0.7-1.61.10.3-1.50.3
Cocaine induced anxiety0.10.20.90.40.10.50.4-0.2-0.30.3-0.8-0.50.00.9-0.7-0.5
Post-drug Anxiety0.20.20.60.6-0.30.10.50.20.2-0.0-0.8-0.4-0.20.7-0.40.0
Baseline Anxiety0.10.10.7-0.00.30.1-0.2-0.00.0-0.30.00.00.3-0.40.20.8
Tail length0.10.61.70.90.70.8-1.3-0.5-0.5-0.3-0.7-1.20.10.1-1.0-0.2
Length with tail0.31.33.10.51.81.5-1.3-1.5-1.60.2-0.8-1.31.00.3-1.20.1
Length without tail0.20.91.90.21.31.0-0.5-1.1-1.10.8-1.0-1.10.20.8-1.4-0.8
Times rat made contact with spout0.91.03.2-0.1-0.30.91.1-1.2-1.1-0.90.30.81.80.60.91.6
Lifetime Intake0.60.72.4-1.41.50.2-0.0-0.9-0.71.20.70.61.3-0.30.00.5
Liver weight, left0.40.61.60.21.20.7-0.9-0.3-0.21.1-0.5-1.2-0.50.5-1.3-0.6
Liver weight, right1.52.54.61.01.72.1-0.7-1.8-1.81.0-1.8-1.90.72.0-2.1-0.7
Locomotor activity0.30.51.2-0.7-0.4-0.21.00.40.2-0.41.01.10.3-0.21.00.9
Locomotor testing distance0.41.12.8-1.1-0.6-0.61.40.20.1-0.71.31.70.7-0.71.41.3
Locomotor testing rearing1.13.911.9-1.3-0.20.53.5-1.5-1.7-1.50.82.73.30.72.22.5
Locomotion in novel chamber1.62.29.52.4-3.10.11.7-0.4-0.4-2.6-0.8-0.1-0.21.21.10.2
Locomotion in novel chamber post-restriction0.31.02.4-0.4-1.3-0.70.21.30.9-1.01.21.2-0.6-1.01.50.9
Fecal boli incidents, locomotor time 10.30.71.6-1.1-0.3-1.00.31.31.20.70.80.5-0.9-1.10.30.6
Change in fecal boli incidents, locomotor task0.80.82.4-0.50.10.31.0-0.3-0.3-1.10.71.41.50.11.31.1
Time >=10cm from walls, locomotor time 11.31.74.51.6-0.51.80.9-1.5-1.6-0.9-1.4-0.61.32.1-0.2-0.5
Bouts of movement, locomotor time 10.70.82.81.0-0.41.10.2-1.6-1.7-1.0-0.8-0.30.41.00.10.4
Total resting periods, locomotor time 10.40.51.80.5-0.20.80.4-1.3-1.4-0.6-0.6-0.10.60.70.10.7
Rest time, locomotor task time 10.20.20.90.2-0.3-0.70.80.20.1-0.4-0.5-0.4-0.9-0.5-0.4-0.1
Distance moved, locomotor task time 10.10.31.0-0.60.20.2-0.50.20.30.00.71.00.8-0.00.80.6
Vertical activity count, locomotor time 10.00.10.5-0.00.10.3-0.70.00.10.00.40.40.50.30.40.2
Time >=10cm from walls, locomotor time 20.10.41.3-0.71.10.1-1.10.40.40.90.1-0.3-0.2-0.6-0.6-0.7
Bouts of movement, locomotor time 20.10.52.00.6-1.4-0.50.3-0.1-0.2-0.7-0.20.2-0.90.30.5-1.3
Total resting periods, locomotor time 20.10.52.30.5-1.5-0.70.8-0.1-0.2-0.8-0.20.4-0.70.30.7-1.2
Rest time, locomotor task time 20.40.62.61.0-1.4-0.41.4-0.2-0.1-1.6-0.3-0.1-0.2-0.10.50.3
Distance moved, locomotor task time 20.30.41.3-0.80.4-0.4-0.70.80.91.10.30.2-0.1-0.2-0.3-1.0
Vertical activity count, locomotor time 20.10.32.00.20.20.0-1.40.40.40.4-0.1-0.4-0.5-0.1-0.3-0.7
Light reinforcement 10.20.92.8-1.71.60.0-0.4-0.4-0.51.01.11.01.3-0.50.30.5
Light reinforcement 20.00.10.2-0.20.0-0.20.3-0.0-0.1-0.40.20.30.3-0.20.20.5
Bone: marrow area0.00.00.10.00.0-0.0-0.00.30.30.0-0.1-0.1-0.20.0-0.2-0.2
Bone: maximum diameter0.51.02.41.20.71.6-1.0-1.0-1.0-0.3-1.3-1.30.21.0-1.2-0.1
Bone: maximum force1.02.03.71.01.61.9-0.5-1.7-1.70.5-1.8-1.60.51.7-1.8-0.5
Bone: maximum moment1.01.93.81.11.41.9-0.2-1.7-1.70.1-1.9-1.40.71.7-1.6-0.3
Mean time between licks in bursts0.00.20.6-0.20.80.5-0.0-0.3-0.30.7-0.00.10.00.7-0.1-0.1
Mean num. licks in bursts0.41.25.70.9-2.0-0.50.30.20.2-2.40.70.6-0.1-0.81.50.8
Cd content in liver1.51.64.10.61.31.60.1-2.0-2.00.4-0.9-0.81.71.6-1.1-0.6
Co content in liver1.72.07.7-2.12.80.1-1.90.00.02.41.20.00.8-1.1-0.70.5
Cu content in liver0.70.85.00.3-1.00.02.2-0.8-0.8-0.5-0.20.60.81.20.6-0.4
Fe content in liver1.11.44.11.7-1.5-0.6-0.60.80.8-0.6-0.7-1.3-2.00.1-0.8-1.9
K content in liver0.50.52.30.6-1.50.01.3-0.1-0.1-1.0-0.00.50.20.60.90.1
Mg content in liver0.20.31.1-0.3-0.60.11.1-0.1-0.1-0.00.40.80.50.50.70.3
Mn content in liver0.50.62.41.0-0.81.0-0.2-0.6-0.6-1.60.20.20.40.60.70.7
Na content in liver0.20.31.10.5-1.00.01.0-0.0-0.0-0.6-0.70.1-0.30.50.10.0
Rb content in liver0.20.30.8-0.50.2-0.70.80.30.30.90.1-0.1-0.7-0.0-0.4-0.6
Se content in liver0.30.41.20.7-1.1-0.4-0.70.50.5-0.60.5-0.2-0.9-0.40.3-0.7
Sr content in liver0.70.62.30.3-1.2-0.1-0.20.00.0-1.50.80.60.3-0.61.11.0
Zn content in liver5.76.731.62.0-3.50.75.6-1.9-1.9-2.1-1.61.12.14.01.5-0.9
Bone: minimum diameter0.81.55.70.12.41.6-1.7-1.3-1.30.4-0.5-1.10.80.2-1.40.4
Time in familiar zone, hab. session 10.40.41.2-0.10.5-0.2-0.50.20.21.1-0.5-0.8-0.8-0.1-1.0-1.1
Time in novel zone, hab. session 10.30.31.30.6-0.70.20.3-0.3-0.3-1.1-0.10.00.40.10.21.1
Total zone transitions, hab. session 12.83.910.1-3.21.5-2.2-0.72.12.12.92.81.3-0.8-2.50.5-0.3
Total locomotion distance, hab. session 10.71.03.0-1.70.7-1.10.61.01.01.71.20.8-0.4-0.70.1-0.3
Locomotion velocity, hab. session 10.60.82.6-1.60.8-0.80.70.90.91.31.21.00.0-0.50.4-0.2
Time in familiar zone, hab. session 21.21.44.11.9-0.51.7-0.8-1.2-1.2-2.0-1.2-0.90.40.9-0.20.6
Time in novel zone, hab. session 21.01.12.8-1.70.2-1.71.10.90.91.61.11.0-0.2-0.70.4-0.6
Total zone transitions, hab. session 21.72.16.1-2.51.5-1.3-0.81.21.22.52.11.0-0.2-1.50.3-0.1
Total locomotion distance, hab. session 20.40.51.5-1.20.6-0.30.20.30.30.71.11.00.7-0.40.60.5
Locomotion velocity, hab. session 20.40.61.7-1.30.4-0.60.50.50.50.71.11.10.5-0.40.70.4
Novel to familiar place preference ratio0.40.51.4-0.90.2-0.40.7-0.2-0.20.20.91.01.2-0.40.80.5
Novelty place preference0.50.72.2-1.00.1-0.40.9-0.3-0.3-0.01.01.31.5-0.51.10.8
Time in novel zone, NPP test0.60.72.4-0.90.0-0.30.7-0.4-0.4-0.21.01.21.5-0.41.10.8
Total zone transitions, NPP test1.21.85.2-2.31.9-0.5-0.91.01.02.12.01.00.2-1.30.40.2
Total locomotion distance, NPP test0.20.31.2-0.71.10.50.3-0.3-0.30.70.30.40.90.50.0-0.1
Locomotion velocity, NPP test0.30.41.3-0.71.10.70.3-0.4-0.50.60.30.51.10.60.10.3
Intraocular pressure0.40.62.11.1-0.20.1-1.00.40.4-0.3-1.1-1.5-0.9-0.1-1.1-0.5
Delta distance traveled before/after self-admin0.91.02.7-1.60.5-0.41.3-0.5-0.50.81.01.41.6-0.10.71.1
Delta ambulatory time before/after self-admin0.50.92.9-1.20.6-0.01.4-0.9-0.90.50.61.11.70.40.51.0
Parametrial fat weight0.40.91.61.00.00.90.6-1.3-1.2-0.0-1.2-1.00.61.3-1.0-0.8
Pavlov. Cond. lever latency0.20.30.8-0.40.70.4-0.9-0.3-0.3-0.00.40.00.7-0.50.00.9
Pavlov. Cond. magazine entry latency0.30.30.8-0.60.1-0.90.10.70.70.60.80.1-0.4-0.8-0.1-0.6
Pavlov. Cond. change in total contacts1.01.12.5-1.5-0.3-1.60.71.21.21.21.21.3-0.5-0.80.9-0.6
Pavlov. Cond. index score0.10.20.60.2-0.6-0.40.80.20.2-0.20.10.2-0.20.20.2-0.6
Pavlov. Cond. latency score0.20.20.90.2-0.8-0.50.90.30.3-0.2-0.00.2-0.40.30.2-0.6
Pavlov. Cond. lever contacts0.20.30.80.7-0.30.30.4-0.3-0.3-0.1-0.7-0.4-0.40.9-0.3-0.9
Pavlov. Cond. magazine entry number0.40.41.31.0-0.70.8-0.0-0.5-0.5-1.1-0.8-0.20.00.80.20.7
Pavlov. Cond. intertrial magazine entries0.20.31.80.50.20.1-0.3-0.3-0.30.4-0.5-0.5-0.30.7-0.5-1.4
Pavlov. Cond. lever-magazine prob. diff.0.20.31.3-0.0-0.8-0.51.10.30.3-0.40.40.60.00.10.7-0.3
Pavlov. Cond. response bias0.30.41.9-0.40.5-0.50.10.40.41.1-0.0-0.3-0.6-0.1-0.7-1.4
Pavlov. Cond. lever latency0.50.72.3-0.1-1.5-1.00.11.01.1-0.50.60.7-1.0-0.81.20.3
Pavlov. Cond. magazine entry latency0.10.10.30.3-0.6-0.40.20.30.3-0.30.0-0.1-0.3-0.1-0.0-0.0
Pavlov. Cond. change in total contacts0.20.51.20.40.50.80.4-1.1-1.1-0.1-0.5-0.40.91.0-0.6-0.1
Pavlov. Cond. index score0.40.61.31.10.00.7-0.1-0.7-0.8-0.4-1.0-1.10.00.8-1.0-0.5
Pavlov. Cond. latency score0.30.41.01.0-0.20.50.2-0.5-0.6-0.3-0.9-0.9-0.00.9-0.8-0.6
Pavlov. Cond. lever contacts0.60.92.20.51.51.2-0.4-1.1-1.20.2-0.8-1.10.80.9-1.4-0.5
Pavlov. Cond. magazine entry number0.20.20.8-0.90.3-0.10.20.20.20.30.50.80.3-0.30.60.5
Pavlov. Cond. intertrial magazine entries0.40.92.20.90.21.40.3-1.3-1.3-1.1-0.9-0.41.51.0-0.30.6
Pavlov. Cond. lever-magazine prob. diff.0.40.61.41.2-0.00.7-0.1-0.7-0.8-0.4-1.0-1.2-0.00.9-1.0-0.6
Pavlov. Cond. response bias0.40.61.60.31.30.9-0.6-0.8-0.90.2-0.5-1.00.40.4-1.2-0.2
Time in closed arm before self-admin0.10.31.9-0.10.20.20.2-0.3-0.10.7-0.1-0.1-0.10.7-0.3-1.4
Time in closed arm after self-admin0.30.41.3-0.20.30.31.0-0.8-0.60.5-0.30.41.01.2-0.1-0.3
Time in open arm before self-admin1.11.46.40.6-0.11.5-0.1-1.0-1.1-1.6-0.20.31.80.30.72.5
Time in open arm after self-admin0.30.31.3-0.20.2-0.8-0.20.80.6-0.10.4-0.2-0.8-1.2-0.00.5
Bone: periosteal estimation0.51.22.80.91.31.7-1.5-1.1-1.1-0.2-1.1-1.30.40.7-1.30.1
Bone: periosteal perimeter0.51.03.60.71.31.3-1.9-0.7-0.70.2-0.9-1.4-0.00.2-1.50.1
Bone: post-yield work0.50.82.4-0.10.0-0.51.20.50.51.3-1.1-0.5-1.10.9-1.0-1.6
Progressive ratio test 1 active lever presses1.01.86.7-2.61.7-0.6-0.1-0.10.01.22.01.61.1-1.50.81.2
Progressive ratio test 1 breakpoint1.01.76.4-2.51.7-0.5-0.0-0.3-0.11.31.81.61.2-1.30.81.2
Progressive ratio test 1 inactive lever presses0.71.74.3-1.5-0.4-1.30.71.00.9-0.52.12.1-0.1-1.51.91.1
Progressive ratio test 2 active lever presses0.40.52.4-0.81.60.5-0.6-0.5-0.30.60.3-0.11.1-0.6-0.50.7
Progressive ratio test 2 breakpoint0.40.51.9-0.71.40.6-0.4-0.6-0.40.40.3-0.01.2-0.5-0.30.9
Progressive ratio test 2 inactive lever presses0.10.40.9-0.70.6-0.5-0.60.80.80.90.7-0.1-0.3-0.9-0.4-0.1
Incentive Sensitization - Responses0.30.72.61.1-0.10.2-0.70.50.40.3-0.9-1.6-0.70.2-1.3-1.3
Incentive Sensitization - Breakpoint0.30.82.81.3-0.20.4-0.70.30.20.0-1.0-1.7-0.60.3-1.3-1.1
Sum of active levers in priming session hrs 5-61.61.53.61.6-0.91.50.9-1.5-1.5-1.9-1.0-0.11.01.60.60.4
Progressive ratio0.30.84.41.0-0.40.6-1.00.20.2-1.5-0.2-0.60.4-0.60.22.1
Food seeking constrained by brief footshock1.51.84.60.81.42.2-0.5-1.7-1.9-0.1-1.4-1.21.81.3-1.30.5
Seeking ratio, punishment vs. effort0.20.51.0-1.00.70.30.9-0.7-0.81.00.10.61.00.7-0.0-0.8
Retroperitoneal fat weight0.41.94.61.21.11.9-0.4-2.1-2.1-0.8-1.5-1.31.31.0-1.10.4
Reaction time number correct0.10.32.2-0.30.20.50.6-0.3-0.3-0.5-0.00.40.9-0.00.31.5
Reaction time mean minus median0.21.03.51.1-1.0-0.4-1.60.90.9-0.5-0.4-0.9-1.9-0.4-0.3-1.1
Reaction time mean minus median AUC0.10.61.70.9-1.1-0.6-0.70.70.7-0.7-0.3-0.4-1.3-0.40.1-0.9
Reaction time num false alarms1.42.45.4-1.7-0.2-2.2-0.62.22.31.41.60.7-1.6-2.20.40.2
Reaction time num false alarms AUC1.02.35.2-1.40.1-1.9-1.42.22.31.41.30.2-1.9-2.2-0.0-0.0
Reaction time trials correct on left0.10.32.2-0.30.20.50.6-0.3-0.3-0.5-0.00.40.9-0.00.31.5
Reaction time trials on left0.10.32.2-0.20.10.40.5-0.2-0.2-0.5-0.00.40.8-0.10.41.5
Reaction time mean0.40.92.20.8-1.4-0.4-1.30.90.8-1.50.20.1-1.4-0.80.80.4
Reaction time mean AUC0.41.02.10.6-1.3-0.5-1.41.00.9-1.50.40.3-1.4-1.11.00.6
Median of all reaction times0.50.72.50.5-1.1-0.2-1.00.60.6-1.60.40.5-0.9-0.81.01.0
Reaction time omissions1.11.85.21.6-2.2-0.7-1.61.41.5-1.1-0.4-1.0-2.3-0.80.1-0.5
Reaction time false alarm rate1.11.63.4-0.9-0.2-1.7-1.11.81.91.21.10.0-1.8-1.6-0.1-0.6
Reaction time premature initiation rate0.20.41.8-0.71.3-0.2-0.7-0.0-0.00.80.4-0.30.3-0.7-0.8-0.2
Reaction time premature initiations0.20.52.3-0.91.50.0-0.90.10.10.70.3-0.20.4-0.9-0.70.7
Std. dev. reaction times0.31.13.51.4-1.6-0.5-1.41.00.9-0.8-0.4-0.9-1.9-0.4-0.1-0.8
Reaction time trials completed0.10.32.2-0.20.10.40.5-0.2-0.2-0.5-0.00.40.8-0.10.41.5
Reaction time trials AUC0.10.31.7-0.20.30.60.4-0.4-0.4-0.4-0.20.20.80.10.21.3
Run reversals in cocaine runway, females0.80.92.5-0.8-0.5-0.31.50.0-0.3-0.80.81.50.8-0.21.51.6
Run reversals in cocaine runway, males1.31.53.4-1.5-0.4-0.50.80.30.3-0.41.71.81.4-1.11.71.7
Latency to leave start box in cocaine runway0.50.72.6-0.7-0.7-0.61.60.30.1-0.10.91.30.70.11.20.3
Latency to leave start box in cocaine runway, F0.20.20.8-0.70.3-0.40.50.20.30.90.40.4-0.10.20.0-0.5
Latency to leave start box in cocaine runway, M1.41.44.60.2-1.6-0.12.2-0.2-0.7-1.50.61.41.50.41.60.7
Std. dev. time between licks in bursts0.81.55.1-2.30.7-1.01.60.40.31.71.61.90.5-0.11.1-0.1
Total sessions with >9 infusions1.82.38.5-2.91.3-1.50.10.60.72.52.21.6-0.1-1.50.8-0.1
Short access day 1 total inactive lever presses0.40.82.8-1.70.9-0.50.50.20.11.41.41.20.4-0.20.7-0.2
Short access day 10 total inactive lever presses0.21.53.4-0.5-1.5-1.80.91.81.8-0.11.21.2-1.2-0.91.30.3
Short access day 1 total infusions0.81.66.4-2.01.2-1.3-0.20.80.92.51.40.6-0.8-1.0-0.1-1.1
Short access day 10 total infusions1.32.27.3-2.70.7-1.61.10.40.71.22.22.30.3-1.41.60.1
Short access total infusions1.62.28.0-2.81.1-1.40.60.50.71.72.32.00.4-1.51.30.6
Short access day 1 locomotion0.71.26.7-1.81.5-0.8-0.10.40.32.61.00.5-0.1-0.2-0.3-1.1
Short access day 10 total locomotion0.00.20.5-0.60.2-0.10.2-0.5-0.70.20.40.70.30.30.6-0.0
Short access total locomotion0.30.51.5-1.20.1-0.70.7-0.1-0.20.71.01.20.2-0.11.0-0.0
One hour access (0.3 mA shock)0.30.41.40.50.20.9-0.1-1.2-1.1-0.3-0.3-0.50.90.6-0.3-0.2
Compulsive drug intake0.40.51.71.3-0.51.1-0.4-0.4-0.6-1.3-0.8-0.5-0.00.8-0.0-0.3
One hour access (shock baseline)0.10.20.9-0.60.3-0.10.4-0.6-0.30.00.50.40.9-0.40.20.6
Social response proportion0.30.41.40.1-1.2-0.5-0.21.00.9-0.30.00.1-1.0-0.50.30.2
Social responses0.60.81.81.1-0.81.30.3-1.1-1.2-1.3-0.8-0.20.71.10.10.5
Social time0.71.23.61.9-1.70.10.20.20.2-1.1-1.4-1.0-1.41.0-0.3-1.2
Soleus weight0.20.63.3-0.11.40.5-1.8-0.3-0.30.2-0.3-0.80.1-0.8-0.80.3
Bone: stiffness0.50.92.30.41.31.5-0.5-1.3-1.30.3-1.0-0.80.61.1-1.0-0.1
Tibialis anterior weight1.96.728.81.13.73.4-5.4-2.2-2.2-0.5-1.3-2.71.4-0.7-2.42.0
Time to tail flick, vehicle, before self-admin0.60.82.1-0.6-0.6-1.30.81.51.30.50.60.5-1.2-0.70.4-0.5
Time to tail flick, vehicle, after self-admin1.12.27.31.8-0.70.1-2.31.31.0-0.1-1.0-2.0-2.7-0.0-1.3-1.6
Time to tail flick, test, before self-admin0.40.41.11.0-1.0-0.70.30.40.4-0.8-0.2-0.4-1.00.00.1-1.0
Time to tail flick, test, after self-admin0.40.41.00.60.40.2-0.90.40.40.5-0.4-0.8-1.00.4-0.7-0.6
Delta time to tail flick, vehicle, before/after SA0.80.96.20.80.30.9-2.50.30.10.4-0.5-1.3-1.00.1-0.8-0.4
Delta time to tail flick, test, before/after SA0.40.41.5-0.31.20.8-0.8-0.2-0.31.1-0.3-0.60.50.3-0.90.1
Tibia length0.71.83.41.60.81.9-1.3-1.6-1.6-1.4-1.7-1.60.60.6-1.30.5
Ambulatory time before self-admin0.20.73.20.6-0.0-0.2-0.90.90.90.20.1-0.8-1.8-0.4-0.3-1.3
Ambulatory time after self-admin0.30.41.9-0.30.2-0.70.30.60.51.10.3-0.2-1.00.0-0.3-1.4
Bone: tissue strength2.02.14.40.81.52.00.0-1.8-1.70.4-2.1-1.31.51.8-1.70.1
Total heroin consumption0.81.02.41.6-0.11.1-0.5-1.3-1.2-0.7-1.1-1.2-0.01.1-0.7-0.9
Bone: trabecular number0.40.72.31.0-1.1-0.6-0.40.70.7-0.1-0.5-0.9-1.50.0-0.5-1.4
Bone: trabecular spacing0.81.12.30.6-0.31.30.8-1.4-1.4-1.5-0.50.51.51.10.71.0
Bone: trabecular thickness0.30.41.2-0.60.1-0.6-0.80.90.90.50.60.1-0.6-1.10.20.3
Bone: trabecular tissue density0.61.02.2-1.20.1-0.8-0.61.41.40.51.50.9-0.8-1.40.80.7
Water consumed over 24 hours0.20.31.0-0.50.80.6-0.7-0.4-0.30.50.50.01.0-0.1-0.00.8
Number of responses in last shaping day2.12.75.3-2.31.3-1.8-1.22.01.92.11.90.8-1.5-2.20.2-0.4