Hub : Genes

Eif4a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Eif4a3 0.11 0.07 7.9e-04 0.07 0.06 0.05 0.04 7.2e-04 1.3e-03 2.8e-03 7.4e-03
2 IL mRNA stability Eif4a3 0.54 0.2 3.2e-07 0.15 0.2 0.21 0.23 2.3e-04 1.6e-05 8.2e-06 2.4e-06
3 Adipose mRNA stability Eif4a3 0.15 0.07 0.0e+00 0.17 0.16 0.17 0.17 4.2e-18 6.1e-18 3.2e-18 1.7e-18
4 BLA mRNA stability Eif4a3 0.08 0.05 5.1e-04 0.06 0.05 0.05 -0 2.5e-04 1.5e-03 9.7e-04 8.2e-01
5 PL mRNA stability Eif4a3 0.21 0.08 0.0e+00 0.26 0.22 0.26 0.11 1.4e-28 7.4e-24 5.6e-28 5.2e-12
6 Brain mRNA stability Eif4a3 0.28 0.12 0.0e+00 0.28 0.27 0.28 0.28 5.9e-26 2.3e-25 7.0e-26 2.3e-26
7 Adipose gene expression Eif4a3 0.2 0.1 0.0e+00 0.21 0.2 0.2 0.21 9.3e-23 2.7e-22 9.4e-22 1.9e-22
8 NAcc mRNA stability Eif4a3 0.13 0.06 7.2e-16 0.15 0.14 0.14 0.06 6.7e-17 6.5e-16 2.9e-16 6.8e-08
9 NAcc gene expression Eif4a3 0.03 0.02 9.6e-04 0.02 0.02 0.01 0.02 2.9e-03 1.0e-03 1.2e-02 3.7e-03
10 Liver mRNA stability Eif4a3 0.02 0.02 6.9e-03 0 0.01 -0 0 1.0e-01 5.1e-02 6.6e-01 1.2e-01
11 LHb mRNA stability Eif4a3 0.33 0.14 6.2e-06 0.17 0.07 0.18 0.11 9.1e-05 1.1e-02 5.0e-05 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.10.20.20.00.00.10.1-0.2-0.20.20.50.5-0.1
Area under the delay curve1.41.42.8-1.71.21.0-1.3-1.21.10.8-1.1-1.5-0.1-1.4
BMI with tail0.61.93.71.3-0.4-0.71.61.6-1.4-1.51.31.9-0.71.8
BMI without tail4.910.117.63.5-1.9-2.23.53.5-3.4-3.43.14.2-1.73.6
Body weight5.322.125.54.7-4.5-4.85.05.0-4.9-4.94.94.3-4.54.0
Weight adjusted by age3.43.84.62.1-1.7-2.02.12.1-2.0-2.11.81.9-1.91.8
Bone surface0.10.20.40.3-0.7-0.50.40.4-0.4-0.50.3-0.0-0.6-0.0
Bone volume0.10.10.20.4-0.4-0.40.40.4-0.4-0.50.40.4-0.10.2
Breakpoint value in progressive ratio session0.70.81.50.9-0.4-0.71.01.0-1.0-1.01.01.2-0.20.9
Number of licking bursts0.20.30.40.5-0.6-0.40.50.5-0.5-0.60.40.5-0.60.5
Context. condit. distance diff. score0.50.61.50.70.0-0.20.70.7-0.7-0.70.71.2-0.51.2
Locomotion velocity, session 14.14.58.3-2.11.51.7-2.2-2.22.22.1-2.2-2.70.7-2.9
Locomotion distance, session 12.22.84.2-1.72.02.0-1.6-1.61.71.6-1.6-1.11.8-1.5
Locomotion velocity, session 25.76.67.4-2.72.32.5-2.7-2.72.72.7-2.7-2.62.3-2.5
Locomotion distance, session 20.50.72.5-0.51.11.0-0.7-0.70.70.7-0.70.01.6-0.5
Locomotion velocity, session 31.82.13.4-1.71.21.2-1.4-1.41.51.5-1.4-1.70.7-1.9
Locomotion distance, session 34.34.65.3-2.32.32.2-2.2-2.22.22.2-2.2-1.91.8-2.2
Stereotopy head waving bouts, day 30.30.30.7-0.70.40.4-0.6-0.60.60.5-0.6-0.90.1-0.5
Stereotopy head waving duration, day 30.10.10.3-0.50.40.3-0.3-0.30.40.3-0.3-0.5-0.1-0.1
Locomotion velocity, session 71.01.11.6-1.01.31.2-1.1-1.11.11.1-1.1-1.00.6-0.4
Locomotion distance, session 73.34.27.9-2.02.82.6-2.0-2.02.02.1-2.0-1.12.3-0.6
Stereotopy head waving bouts, day 70.40.51.20.5-0.3-0.50.70.7-0.7-0.80.70.6-1.10.8
Stereotopy head waving duration, day 70.91.12.90.9-1.0-1.11.11.1-1.0-1.11.10.6-1.70.6
Locomotion velocity, session 80.20.20.8-0.60.90.8-0.4-0.40.40.3-0.4-0.2-0.30.3
Locomotion distance, session 80.40.62.40.50.80.30.40.4-0.4-0.40.41.60.71.2
Degree of sensitization distance0.90.93.21.0-0.3-0.50.90.9-0.9-0.90.91.40.01.8
Degree of sensitization stereotypy0.80.91.20.9-0.6-0.81.01.0-1.0-1.11.01.0-1.10.8
Conditioned locomotion5.05.97.92.5-2.1-2.22.52.5-2.5-2.52.62.8-1.52.7
Cocaine response after cond. corrected0.10.10.2-0.30.30.3-0.4-0.40.40.4-0.4-0.40.1-0.4
Cocaine response after cond. not corrected0.90.91.4-0.90.80.9-1.0-1.01.01.0-1.0-1.10.5-1.2
Cocaine response before conditioning1.01.21.5-1.21.01.1-1.1-1.11.11.1-1.1-1.20.6-1.2
Saline control response3.03.95.12.1-2.1-2.32.02.0-2.0-2.02.11.7-2.01.2
Bone: connectivity density0.10.20.4-0.30.50.6-0.3-0.30.30.3-0.4-0.00.6-0.2
Bone: cortical apparent density3.14.15.4-2.22.02.2-2.0-2.02.12.1-2.0-1.62.3-1.5
Bone: cortical area7.311.015.03.5-3.9-3.63.43.4-3.4-3.53.32.7-3.32.3
Bone: cortical porosity0.60.61.70.6-1.3-1.30.70.7-0.7-0.60.7-0.2-1.1-0.2
Bone: cortical porosity0.80.91.80.8-1.3-1.40.90.9-0.9-0.90.90.1-1.30.1
Bone: cortical thickness6.09.814.33.3-3.8-3.53.23.2-3.2-3.33.22.6-2.72.1
Bone: cortical thickness2.22.53.51.6-1.9-1.61.61.6-1.6-1.81.61.4-1.51.1
Bone: cortical tissue density3.64.76.1-2.32.22.4-2.2-2.22.22.3-2.2-1.82.5-1.6
Condit. Reinf. active minus inactive responses2.62.93.61.9-1.7-1.61.81.8-1.8-1.71.81.9-1.01.7
Condit. Reinf. active-inactive response ratio1.31.42.11.2-1.0-1.01.21.2-1.2-1.11.21.5-0.61.5
Condit. Reinf. active responses4.35.36.92.6-2.3-2.32.42.4-2.4-2.32.42.5-1.42.0
Condit. Reinf. inactive responses0.91.11.81.3-1.1-1.11.11.1-1.1-1.01.11.1-0.50.7
Incentive salience index mean2.22.73.71.9-1.7-1.61.71.7-1.7-1.61.71.7-1.11.5
Condit. Reinf. lever presses0.10.10.30.6-0.2-0.20.30.3-0.3-0.30.30.50.00.5
Condit. Reinf. active minus inactive responses1.41.82.81.3-1.3-1.41.31.3-1.3-1.31.41.1-1.71.1
Condit. Reinf. active-inactive response ratio2.93.03.81.8-1.8-1.91.81.8-1.8-1.81.81.4-1.91.2
Condit. Reinf. active responses0.40.51.00.7-0.2-0.50.70.7-0.7-0.70.81.0-0.61.0
Condit. Reinf. inactive responses0.60.71.7-0.81.31.1-0.8-0.80.80.7-0.6-0.11.1-0.1
Condit. Reinf. lever presses0.50.72.30.70.3-0.10.70.7-0.7-0.80.71.40.21.5
Condit. Reinf. lever reinforcers received0.40.51.60.60.1-0.30.70.7-0.7-0.70.81.2-0.31.2
Conditioned reinforcement - actives0.30.30.60.80.0-0.40.60.6-0.6-0.50.40.7-0.10.5
Conditioned reinforcement - inactives2.02.33.01.4-1.4-1.51.71.6-1.5-1.61.41.3-1.21.7
Conditioned locomotion0.70.91.31.0-0.7-0.91.11.1-1.0-1.00.81.0-0.31.0
Patch foraging indifference point 0 sec0.50.71.70.8-0.4-0.61.01.0-0.9-0.80.81.30.50.9
Patch foraging indifference point AUC0.10.10.20.1-0.0-0.20.30.4-0.2-0.20.30.30.10.4
Delay disc. indifference point, 0s delay0.10.11.1-0.2-0.1-0.3-0.0-0.1-0.2-0.20.2-0.3-1.1-0.2
Delay disc. indifference point, 16s delay0.90.92.1-1.31.51.1-1.2-1.10.80.6-0.7-0.50.9-0.4
Delay disc. indifference point, 2s delay0.20.20.6-0.70.30.1-0.3-0.20.2-0.0-0.3-0.6-0.8-0.6
Delay disc. indifference point, 24s delay5.14.96.6-2.52.02.0-2.6-2.62.22.0-2.2-2.41.6-2.2
Delay disc. indifference point, 4s delay0.20.30.9-0.70.4-0.0-0.2-0.30.2-0.1-0.1-0.6-1.0-0.8
Delay disc. indifference point, 8s delay1.51.53.5-1.50.80.7-1.2-1.11.21.0-1.2-1.9-0.7-1.6
Indifference point function ln k1.21.72.4-1.21.51.6-1.3-1.31.31.2-1.3-0.81.5-1.0
Indifference point function log k1.21.72.4-1.21.51.6-1.3-1.31.31.2-1.3-0.81.5-1.0
Patch foraging total patch changes 0 sec0.50.92.30.9-0.3-0.51.11.0-0.9-0.80.91.50.71.1
Patch foraging total patch changes 12 sec0.50.61.10.4-0.3-0.60.91.0-0.7-0.70.91.00.71.0
Patch foraging total patch changes 18 sec0.20.31.20.10.60.10.40.5-0.4-0.30.51.10.80.6
Patch foraging total patch changes 24 sec1.82.23.11.6-1.2-1.31.81.7-1.6-1.51.51.7-0.91.3
Patch foraging total patch changes 6 sec0.91.31.81.1-1.1-1.31.21.3-1.3-1.11.31.30.10.7
Patch foraging time to switch 0 sec0.81.32.0-1.20.90.9-1.3-1.31.21.3-1.1-1.40.5-1.2
Patch foraging water rate 0 sec4.47.010.32.7-2.0-2.12.82.9-2.8-2.92.73.2-1.63.0
Patch foraging water rate 12 sec0.40.62.10.80.40.30.60.6-0.6-0.50.31.40.51.4
Patch foraging water rate 18 sec1.52.04.51.5-0.5-0.71.51.5-1.5-1.51.32.1-0.41.8
Patch foraging water rate 24 sec4.05.612.62.3-0.8-1.42.42.5-2.5-2.42.53.6-0.53.2
Patch foraging water rate 6 sec0.20.31.10.8-0.0-0.00.60.6-0.6-0.60.31.0-0.10.5
Seeking ratio, delayed vs. immediate footshock0.81.01.71.3-0.8-1.11.10.9-1.1-1.00.70.8-1.20.5
Distance traveled before self-admin1.01.12.51.0-0.9-1.20.90.9-1.1-1.11.10.7-1.60.8
Distance traveled after self-admin0.60.61.81.1-0.2-0.20.70.7-0.8-0.80.61.30.21.0
Extensor digitorum longus weight0.20.62.20.30.80.40.30.3-0.3-0.40.41.51.11.3
Bone: elastic displacement1.82.02.61.4-1.4-1.51.51.5-1.5-1.51.51.6-0.61.2
Bone: elastic work7.29.312.73.1-3.6-3.53.23.2-3.2-3.23.22.6-2.42.0
Bone: endosteal estimation0.00.00.2-0.10.40.1-0.0-0.00.0-0.1-0.10.20.00.3
Bone: endosteal perimeter0.71.43.01.2-1.6-1.31.11.1-1.1-1.21.00.4-1.70.5
Epididymis fat weight1.63.75.02.0-1.5-1.61.92.0-2.1-2.22.02.2-1.52.2
Delta time in closed arm before/after self-admin0.20.20.60.3-0.7-0.50.30.3-0.3-0.40.1-0.0-0.8-0.0
Delta time in open arm before/after self-admin0.50.51.10.50.1-0.30.90.9-0.7-0.70.91.00.10.8
Diff in mean of infusions in LGA sessions0.00.00.1-0.20.30.10.30.3-0.1-0.10.10.2-0.00.1
Delay discount exponential model param1.92.03.92.0-1.4-1.21.51.4-1.3-1.11.31.80.01.7
Extinction: sum of active levers before priming1.21.22.0-1.11.31.4-1.1-1.01.11.0-1.0-0.81.2-0.9
Active lever presses in extinction session 60.40.40.60.5-0.3-0.50.70.7-0.7-0.80.60.8-0.40.6
Bone: final force6.310.212.53.3-3.5-3.53.33.3-3.3-3.23.42.7-3.12.2
Bone: final moment7.211.814.03.6-3.7-3.73.63.6-3.6-3.53.63.0-3.22.5
Food consumed during 24 hour testing period1.31.53.21.3-1.1-1.01.21.2-1.2-1.21.11.4-1.01.8
Glucose3.75.57.1-2.51.82.0-2.4-2.42.42.3-2.4-2.62.0-2.7
Heart weight0.50.70.90.9-0.8-0.90.90.8-0.9-0.91.00.9-0.30.6
Delay discount hyperbolic model param1.61.73.41.9-1.3-1.11.31.3-1.2-0.91.21.60.11.6
Intermittent access intake day 1-15 change0.10.10.40.5-0.2-0.20.30.2-0.3-0.30.20.2-0.70.4
Intermittent access intake escalation0.20.20.40.6-0.3-0.40.50.4-0.5-0.50.40.4-0.70.5
Intermittent access intake escalation 20.50.51.00.9-0.5-0.70.70.7-0.7-0.60.50.4-1.00.4
Intermitt. access day 1 inactive lever presses2.62.84.01.6-2.0-1.71.71.6-1.7-1.81.61.4-1.61.7
Intermitt. access day 15 inactive lever presses2.02.13.11.7-1.2-1.21.61.5-1.5-1.51.41.7-0.91.6
Intermitt. access escalation Index2.21.92.71.5-1.7-1.31.31.4-1.4-1.41.31.3-1.11.4
Intermittent access day 1 total infusions0.30.30.50.5-0.2-0.50.70.7-0.6-0.70.50.7-0.00.6
Intermittent access day 15 total infusions0.70.81.10.9-0.5-0.91.01.0-1.0-1.10.80.9-0.61.0
Intermittent access terminal intake (last 3 days)1.01.11.41.2-0.6-1.11.21.2-1.1-1.20.91.0-0.90.9
Intermittent access total infusions0.70.81.10.9-0.5-0.81.01.1-0.9-1.00.70.9-0.41.1
Intermittent access day 1 locomotion1.01.11.51.0-0.9-0.91.21.2-1.1-1.21.01.2-0.21.2
Intermittent access day 15 total locomotion0.40.50.70.8-0.5-0.80.80.8-0.7-0.80.60.6-0.60.5
Intermittent access total locomotion1.01.11.61.0-0.8-1.01.21.2-1.1-1.31.01.2-0.51.2
Intermittent access standard deviation0.30.30.7-0.70.60.4-0.3-0.50.50.4-0.6-0.9-0.7-0.4
Left kidney weight0.41.04.50.5-1.3-1.40.70.7-0.7-0.70.9-0.3-2.1-0.2
Right kidney weight0.41.03.00.5-1.3-1.30.80.8-0.9-0.91.00.1-1.7-0.1
Cocaine induced anxiety5.66.47.52.3-2.7-2.72.72.7-2.6-2.72.52.1-2.72.0
Post-drug Anxiety1.61.82.70.6-1.0-1.31.41.6-1.4-1.71.61.3-1.31.3
Baseline Anxiety6.97.39.0-3.02.92.9-2.9-2.72.82.8-2.6-2.52.4-2.1
Tail length7.221.724.65.0-4.6-4.94.94.9-4.9-4.94.84.5-4.03.7
Length with tail4.215.221.53.8-4.6-4.63.94.0-4.0-3.94.02.7-4.52.4
Length without tail0.30.72.9-0.2-1.3-1.20.10.1-0.1-0.10.4-1.1-1.7-0.8
Times rat made contact with spout1.41.62.81.4-1.7-1.41.31.3-1.3-1.31.21.2-0.81.0
Lifetime Intake0.20.20.30.4-0.2-0.30.50.6-0.4-0.50.30.4-0.20.6
Liver weight, left0.20.30.9-0.3-0.2-0.2-0.3-0.40.30.3-0.3-1.0-0.8-0.9
Liver weight, right3.35.58.82.3-2.9-3.02.32.3-2.3-2.22.41.4-2.61.2
Locomotor activity0.40.71.1-0.81.00.9-0.7-0.60.81.0-0.9-0.80.7-1.0
Locomotor testing distance0.20.40.8-0.50.90.9-0.4-0.40.50.7-0.7-0.40.5-0.6
Locomotor testing rearing0.10.20.80.40.40.10.60.6-0.4-0.30.40.90.30.5
Locomotion in novel chamber0.10.10.30.10.0-0.20.30.3-0.4-0.50.50.50.10.4
Locomotion in novel chamber post-restriction0.70.81.51.0-1.2-0.90.80.7-0.9-0.80.90.8-0.41.2
Fecal boli incidents, locomotor time 10.90.91.8-0.50.81.3-0.9-1.11.01.0-1.2-0.61.4-0.5
Change in fecal boli incidents, locomotor task3.93.75.3-2.32.21.7-1.8-1.71.91.8-1.9-1.91.7-2.1
Time >=10cm from walls, locomotor time 10.10.10.40.10.60.6-0.00.20.0-0.0-0.10.30.10.5
Bouts of movement, locomotor time 12.42.63.6-1.71.31.9-1.4-1.51.61.6-1.9-1.51.7-1.5
Total resting periods, locomotor time 13.13.44.5-1.81.52.1-1.7-1.71.91.8-2.1-1.72.0-1.8
Rest time, locomotor task time 10.30.40.7-0.40.10.5-0.4-0.40.60.6-0.9-0.80.6-0.8
Distance moved, locomotor task time 11.01.11.60.8-0.6-1.21.01.2-1.1-1.11.31.1-1.01.2
Vertical activity count, locomotor time 11.01.02.01.0-0.7-0.80.90.8-1.0-0.91.21.3-0.71.4
Time >=10cm from walls, locomotor time 20.10.10.3-0.10.1-0.50.10.4-0.3-0.40.50.2-0.00.3
Bouts of movement, locomotor time 21.51.72.7-1.61.11.4-1.2-1.21.31.2-1.4-1.21.1-1.2
Total resting periods, locomotor time 21.01.01.7-1.30.81.2-0.9-0.91.00.9-1.2-0.90.9-0.9
Rest time, locomotor task time 20.10.10.3-0.40.10.5-0.2-0.30.40.3-0.6-0.50.3-0.3
Distance moved, locomotor task time 20.50.61.30.6-0.5-1.10.60.9-0.9-0.80.90.5-1.00.3
Vertical activity count, locomotor time 20.40.50.70.7-0.5-0.60.60.7-0.7-0.60.80.8-0.60.7
Light reinforcement 11.83.26.12.1-1.1-1.32.02.0-1.9-1.81.82.5-0.62.0
Light reinforcement 22.53.34.42.1-1.8-1.91.81.7-1.8-1.81.91.8-1.61.6
Bone: marrow area0.00.00.2-0.10.40.2-0.0-0.00.0-0.1-0.10.2-0.00.3
Bone: maximum diameter2.24.07.72.1-2.5-2.21.91.9-2.0-2.01.91.1-2.81.2
Bone: maximum force5.910.212.23.3-3.4-3.53.33.3-3.3-3.33.32.8-2.92.3
Bone: maximum moment6.811.713.53.6-3.6-3.73.63.6-3.6-3.53.53.1-3.02.6
Mean time between licks in bursts1.21.72.5-1.61.21.3-1.4-1.41.41.4-1.3-1.31.0-0.8
Mean num. licks in bursts0.20.20.40.4-0.5-0.60.40.4-0.4-0.40.50.60.20.4
Cd content in liver1.21.32.4-1.31.51.4-1.0-1.01.11.1-1.0-0.41.4-0.7
Co content in liver0.10.10.7-0.10.40.2-0.1-0.10.10.1-0.20.40.80.4
Cu content in liver0.10.20.60.3-0.8-0.60.30.3-0.3-0.30.3-0.0-0.20.1
Fe content in liver0.60.81.2-1.01.11.0-0.9-0.90.90.9-0.9-0.60.9-0.4
K content in liver2.52.53.11.7-1.6-1.71.61.6-1.6-1.51.61.6-1.21.7
Mg content in liver0.30.31.20.50.0-0.10.30.3-0.3-0.30.30.90.51.1
Mn content in liver0.30.31.20.5-0.8-0.80.40.4-0.4-0.30.4-0.1-1.10.4
Na content in liver0.10.10.20.2-0.4-0.3-0.1-0.10.00.10.0-0.3-0.4-0.4
Rb content in liver1.21.53.41.2-0.6-1.01.21.2-1.3-1.31.31.7-0.31.8
Se content in liver0.30.41.00.5-0.4-0.60.70.7-0.6-0.50.60.7-0.51.0
Sr content in liver0.20.20.9-0.3-0.3-0.2-0.2-0.20.30.3-0.3-0.80.3-0.9
Zn content in liver0.10.10.5-0.0-0.5-0.3-0.1-0.10.20.2-0.2-0.7-0.2-0.7
Bone: minimum diameter4.27.99.03.0-3.0-3.02.92.9-2.9-2.92.92.4-2.72.1
Time in familiar zone, hab. session 10.10.10.5-0.30.30.2-0.2-0.20.20.1-0.20.10.70.1
Time in novel zone, hab. session 10.10.10.70.1-0.1-0.10.10.1-0.1-0.10.1-0.1-0.8-0.1
Total zone transitions, hab. session 10.30.41.1-0.50.90.8-0.4-0.40.50.4-0.40.11.1-0.0
Total locomotion distance, hab. session 10.40.61.90.8-0.1-0.30.80.8-0.8-0.80.81.40.11.2
Locomotion velocity, hab. session 10.50.71.90.9-0.2-0.40.80.8-0.8-0.80.81.40.21.3
Time in familiar zone, hab. session 20.20.20.6-0.40.80.7-0.4-0.40.40.3-0.4-0.10.60.3
Time in novel zone, hab. session 20.10.10.3-0.30.00.1-0.2-0.20.20.3-0.2-0.4-0.1-0.6
Total zone transitions, hab. session 20.40.52.4-0.21.20.8-0.3-0.30.30.2-0.30.71.50.7
Total locomotion distance, hab. session 20.70.93.01.0-0.0-0.40.80.8-0.9-0.90.81.70.71.5
Locomotion velocity, hab. session 20.91.33.51.3-0.4-0.71.11.1-1.1-1.11.11.90.41.5
Novel to familiar place preference ratio2.22.33.81.5-1.4-1.61.61.6-1.6-1.61.61.9-0.21.2
Novelty place preference2.12.13.31.5-1.4-1.51.61.6-1.6-1.51.61.8-0.31.1
Time in novel zone, NPP test1.81.83.31.4-1.2-1.41.51.5-1.4-1.41.51.8-0.11.1
Total zone transitions, NPP test0.30.51.7-0.41.21.0-0.4-0.40.40.3-0.40.41.30.3
Total locomotion distance, NPP test0.50.72.70.60.50.20.50.5-0.5-0.50.51.61.21.4
Locomotion velocity, NPP test0.50.82.70.80.30.00.70.7-0.6-0.70.71.61.01.4
Intraocular pressure0.50.71.70.5-0.3-0.60.80.8-0.9-1.11.01.30.30.9
Delta distance traveled before/after self-admin0.20.31.40.20.60.60.0-0.00.0-0.0-0.10.71.20.3
Delta ambulatory time before/after self-admin0.60.62.7-0.41.11.0-0.5-0.60.60.6-0.60.11.7-0.2
Parametrial fat weight2.03.84.72.0-2.0-2.22.02.1-2.1-2.12.11.8-1.51.7
Pavlov. Cond. lever latency1.11.44.1-1.12.01.8-1.1-1.11.01.0-1.0-0.01.20.5
Pavlov. Cond. magazine entry latency2.63.45.71.9-2.4-2.21.81.8-1.8-1.91.70.9-2.20.9
Pavlov. Cond. change in total contacts0.20.20.40.4-0.7-0.60.40.4-0.4-0.40.40.30.1-0.1
Pavlov. Cond. index score4.05.18.32.3-2.9-2.82.32.3-2.3-2.32.21.3-2.31.0
Pavlov. Cond. latency score3.03.97.32.0-2.7-2.62.02.0-1.9-1.91.90.9-2.20.6
Pavlov. Cond. lever contacts1.11.32.91.2-1.7-1.61.21.2-1.1-1.11.10.5-0.8-0.0
Pavlov. Cond. magazine entry number2.02.54.7-1.52.22.0-1.6-1.61.51.6-1.5-0.62.0-0.7
Pavlov. Cond. intertrial magazine entries0.10.20.60.30.20.10.20.2-0.2-0.20.20.80.80.6
Pavlov. Cond. lever-magazine prob. diff.4.25.28.02.4-2.8-2.72.42.4-2.3-2.42.31.5-2.31.2
Pavlov. Cond. response bias2.22.75.11.7-2.3-2.01.71.7-1.6-1.61.60.8-1.70.6
Pavlov. Cond. lever latency1.11.53.7-1.20.10.6-1.2-1.21.21.3-1.2-1.9-0.1-1.9
Pavlov. Cond. magazine entry latency1.11.23.4-1.11.91.4-1.0-1.01.00.9-0.80.01.7-0.1
Pavlov. Cond. change in total contacts0.30.41.3-0.21.10.7-0.2-0.20.20.1-0.10.81.10.6
Pavlov. Cond. index score0.30.41.20.10.90.40.10.1-0.1-0.30.21.10.91.0
Pavlov. Cond. latency score0.30.41.30.20.80.30.20.2-0.2-0.30.31.20.71.1
Pavlov. Cond. lever contacts1.42.04.51.4-0.3-0.81.41.4-1.4-1.51.42.1-0.22.1
Pavlov. Cond. magazine entry number0.81.03.10.8-1.8-1.30.80.8-0.8-0.70.6-0.4-1.7-0.2
Pavlov. Cond. intertrial magazine entries1.92.42.91.6-1.6-1.51.61.6-1.6-1.51.51.3-1.71.5
Pavlov. Cond. lever-magazine prob. diff.0.30.41.3-0.11.10.7-0.1-0.10.1-0.00.00.91.10.9
Pavlov. Cond. response bias0.40.62.00.50.50.00.50.5-0.5-0.60.61.40.61.3
Time in closed arm before self-admin0.60.71.4-1.20.50.7-0.9-0.90.90.8-0.7-1.00.7-0.9
Time in closed arm after self-admin1.01.12.4-1.50.10.5-1.2-1.11.00.8-1.0-1.60.3-1.3
Time in open arm before self-admin0.10.10.20.1-0.1-0.1-0.4-0.40.20.4-0.3-0.4-0.4-0.1
Time in open arm after self-admin0.10.10.30.20.50.20.30.2-0.10.00.10.30.20.2
Bone: periosteal estimation2.24.55.32.1-2.2-2.32.22.2-2.2-2.32.11.8-2.11.7
Bone: periosteal perimeter3.55.811.12.4-3.3-2.92.32.3-2.4-2.42.31.1-3.01.0
Bone: post-yield work0.00.10.40.00.20.20.00.0-0.0-0.10.10.40.70.1
Progressive ratio test 1 active lever presses0.80.91.51.2-0.9-0.70.90.9-0.9-1.00.71.0-0.41.2
Progressive ratio test 1 breakpoint0.91.01.71.3-1.0-0.71.01.0-1.0-1.00.71.1-0.41.3
Progressive ratio test 1 inactive lever presses4.34.75.72.3-2.1-2.02.32.2-2.2-2.22.12.2-1.82.4
Progressive ratio test 2 active lever presses0.50.50.70.7-0.6-0.70.80.8-0.7-0.80.60.7-0.40.8
Progressive ratio test 2 breakpoint0.60.60.90.8-0.7-0.70.90.9-0.8-0.90.70.8-0.50.9
Progressive ratio test 2 inactive lever presses0.70.81.00.9-0.7-0.91.00.9-0.9-1.00.70.8-0.91.0
Incentive Sensitization - Responses0.00.00.10.1-0.2-0.00.10.1-0.0-0.1-0.1-0.1-0.30.1
Incentive Sensitization - Breakpoint0.00.00.10.1-0.2-0.00.10.1-0.0-0.1-0.1-0.1-0.40.1
Sum of active levers in priming session hrs 5-60.20.20.60.6-0.3-0.10.30.3-0.5-0.50.50.8-0.10.6
Progressive ratio0.60.71.1-0.61.00.9-0.8-0.90.70.6-1.0-0.51.0-1.0
Food seeking constrained by brief footshock0.20.20.6-0.30.60.8-0.2-0.30.30.4-0.5-0.30.1-0.6
Seeking ratio, punishment vs. effort0.20.20.70.4-0.5-0.20.50.5-0.4-0.30.50.3-0.80.4
Retroperitoneal fat weight6.922.524.64.9-4.3-4.64.94.9-4.9-4.94.94.8-4.05.0
Reaction time number correct0.81.24.20.91.00.50.80.8-0.9-0.80.72.00.61.8
Reaction time mean minus median0.20.20.8-0.5-0.00.2-0.5-0.40.50.6-0.4-0.9-0.0-0.5
Reaction time mean minus median AUC0.20.30.90.3-0.7-0.60.40.5-0.4-0.30.5-0.1-0.90.1
Reaction time num false alarms0.20.30.6-0.60.60.5-0.5-0.50.50.4-0.4-0.40.8-0.2
Reaction time num false alarms AUC0.40.61.0-0.90.90.8-0.7-0.70.80.7-0.7-0.61.0-0.4
Reaction time trials correct on left0.81.24.20.91.00.50.80.8-0.9-0.80.72.00.61.8
Reaction time trials on left0.91.34.31.01.00.50.90.8-0.9-0.90.72.10.61.9
Reaction time mean0.10.20.40.5-0.2-0.20.40.4-0.4-0.30.50.5-0.40.6
Reaction time mean AUC0.10.20.40.5-0.1-0.20.40.5-0.4-0.30.50.7-0.30.7
Median of all reaction times0.20.30.60.6-0.1-0.30.50.5-0.5-0.40.60.8-0.40.6
Reaction time omissions0.30.41.00.6-0.4-0.60.50.5-0.6-0.50.70.4-1.00.6
Reaction time false alarm rate0.91.22.7-1.30.40.5-1.1-1.21.21.1-1.0-1.70.6-1.3
Reaction time premature initiation rate1.41.94.3-1.51.51.4-1.4-1.31.31.4-1.2-0.92.1-0.6
Reaction time premature initiations0.91.34.9-0.81.91.5-0.7-0.70.70.7-0.70.42.20.7
Std. dev. reaction times0.30.40.7-0.80.80.8-0.7-0.60.70.8-0.6-0.60.5-0.2
Reaction time trials completed0.91.34.31.01.00.50.90.8-0.9-0.90.72.10.61.9
Reaction time trials AUC1.01.44.71.00.90.40.90.9-1.0-0.90.82.20.62.0
Run reversals in cocaine runway, females0.50.51.5-0.61.21.1-0.5-0.60.50.5-0.4-0.10.9-0.4
Run reversals in cocaine runway, males0.20.20.50.7-0.7-0.70.40.4-0.4-0.40.30.2-0.50.1
Latency to leave start box in cocaine runway1.01.11.6-0.81.01.0-1.3-1.21.11.2-0.9-0.81.3-1.0
Latency to leave start box in cocaine runway, F0.20.20.7-0.50.70.4-0.5-0.40.40.4-0.1-0.10.9-0.3
Latency to leave start box in cocaine runway, M0.60.61.2-0.30.30.6-0.9-1.00.80.9-0.8-0.51.1-0.5
Std. dev. time between licks in bursts0.91.02.80.8-0.7-0.51.01.0-1.0-1.01.01.6-0.21.7
Total sessions with >9 infusions0.70.71.3-0.70.91.0-0.9-0.90.90.7-1.1-1.00.3-0.8
Short access day 1 total inactive lever presses0.30.30.60.8-0.7-0.60.50.5-0.5-0.50.40.3-0.60.8
Short access day 10 total inactive lever presses4.44.95.42.2-2.2-2.32.32.3-2.3-2.22.22.0-2.22.2
Short access day 1 total infusions1.21.31.8-1.41.21.3-1.1-1.11.21.1-1.3-1.20.8-1.0
Short access day 10 total infusions0.60.60.90.9-0.8-0.80.90.9-0.8-0.80.60.7-0.60.9
Short access total infusions0.00.00.1-0.10.20.3-0.1-0.10.20.1-0.3-0.20.30.0
Short access day 1 locomotion0.40.41.2-0.60.30.4-0.5-0.50.60.5-0.8-0.90.1-1.1
Short access day 10 total locomotion0.20.20.5-0.60.20.2-0.3-0.40.40.3-0.4-0.70.0-0.5
Short access total locomotion0.80.81.5-1.00.60.8-0.8-0.90.90.8-1.1-1.20.3-1.2
One hour access (0.3 mA shock)1.31.52.51.3-0.8-1.11.31.3-1.3-1.41.21.6-0.51.4
Compulsive drug intake1.01.01.60.6-0.9-1.00.91.0-1.1-1.21.31.3-0.41.1
One hour access (shock baseline)0.20.20.50.7-0.3-0.40.50.5-0.5-0.40.20.4-0.40.6
Social response proportion0.10.10.3-0.30.50.2-0.00.00.1-0.00.00.20.20.6
Social responses0.30.40.70.5-0.2-0.50.70.7-0.5-0.70.60.7-0.40.8
Social time0.10.10.2-0.10.50.5-0.1-0.10.1-0.2-0.10.30.50.4
Soleus weight1.74.95.92.4-2.4-2.42.32.3-2.4-2.42.42.2-1.11.6
Bone: stiffness0.61.02.01.0-1.2-1.21.01.0-0.9-0.81.00.5-1.40.3
Tibialis anterior weight0.00.10.6-0.10.30.2-0.2-0.20.20.1-0.10.10.8-0.0
Time to tail flick, vehicle, before self-admin0.20.20.40.3-0.7-0.60.40.4-0.4-0.30.50.4-0.00.2
Time to tail flick, vehicle, after self-admin1.81.92.8-1.71.11.2-1.5-1.41.51.4-1.3-1.71.1-1.2
Time to tail flick, test, before self-admin0.00.00.1-0.30.00.1-0.1-0.00.10.1-0.1-0.2-0.0-0.0
Time to tail flick, test, after self-admin0.10.10.4-0.2-0.1-0.20.20.3-0.2-0.30.30.0-0.7-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.20.50.3-0.1-0.10.10.0-0.10.10.50.4
Delta time to tail flick, test, before/after SA0.20.20.4-0.50.60.5-0.4-0.40.40.4-0.5-0.6-0.1-0.6
Tibia length10.228.754.05.3-6.3-6.05.35.3-5.3-5.35.23.0-7.33.2
Ambulatory time before self-admin2.52.64.61.5-1.5-1.61.51.6-1.7-1.71.71.3-2.11.4
Ambulatory time after self-admin0.70.81.71.1-0.4-0.50.80.8-1.0-1.01.01.3-0.30.9
Bone: tissue strength2.32.34.01.5-1.0-1.41.61.6-1.6-1.51.62.0-0.41.7
Total heroin consumption0.10.10.70.3-0.2-0.20.20.2-0.2-0.10.10.0-0.90.0
Bone: trabecular number0.10.20.5-0.30.30.3-0.4-0.40.40.4-0.3-0.40.4-0.7
Bone: trabecular spacing1.11.54.91.0-0.0-0.61.11.1-1.1-1.21.01.8-0.92.2
Bone: trabecular thickness0.10.10.60.2-0.7-0.40.10.1-0.10.00.2-0.30.3-0.7
Bone: trabecular tissue density0.60.91.6-1.20.70.7-1.0-1.01.01.0-1.0-1.30.3-0.9
Water consumed over 24 hours0.00.00.10.1-0.3-0.3-0.0-0.00.00.00.0-0.20.0-0.3
Number of responses in last shaping day1.41.43.11.5-1.8-1.21.11.0-1.0-0.90.90.6-1.60.9