Hub : Genes

Eif4a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Eif4a3 0.16 0.08 0.0e+00 0.16 0.16 0.17 0.17 3.3e-17 7.6e-18 8.3e-19 1.3e-18
2 PL mRNA stability Eif4a3 0.22 0.08 0.0e+00 0.27 0.2 0.26 0.09 4.1e-29 4.3e-21 1.1e-28 5.9e-10
3 BLA mRNA stability Eif4a3 0.08 0.05 1.0e-03 0.07 0.03 0.05 -0 1.9e-04 6.8e-03 7.8e-04 5.9e-01
4 Brain mRNA stability Eif4a3 0.28 0.12 0.0e+00 0.29 0.28 0.28 0.29 2.1e-27 4.6e-26 6.2e-26 3.7e-27
5 NAcc mRNA stability Eif4a3 0.15 0.07 0.0e+00 0.15 0.09 0.15 0.06 4.3e-22 2.4e-13 8.7e-22 7.4e-10
6 OFC mRNA stability Eif4a3 0.19 0.11 7.1e-03 0.01 -0.01 0.03 0.03 2.1e-01 7.2e-01 7.5e-02 8.2e-02
7 IC mRNA stability Eif4a3 0.25 0.14 3.5e-05 0.04 0.08 0.05 0.08 6.0e-03 3.5e-04 4.8e-03 2.7e-04
8 IL mRNA stability Eif4a3 0.5 0.2 4.7e-07 0.16 0.19 0.21 0.2 1.5e-04 2.2e-05 1.0e-05 1.9e-05
9 Adipose gene expression Eif4a3 0.19 0.09 0.0e+00 0.21 0.21 0.2 0.2 1.2e-22 1.6e-22 2.2e-22 2.6e-22
10 Liver mRNA stability Eif4a3 0.02 0.02 6.3e-03 0 0.01 -0 0 1.1e-01 4.3e-02 5.5e-01 1.3e-01
11 LHb mRNA stability Eif4a3 0.32 0.14 1.6e-05 0.1 0.05 0.16 0.06 2.4e-03 3.0e-02 1.7e-04 1.3e-02
12 NAcc gene expression Eif4a3 0.03 0.02 6.9e-04 0.01 0.01 0.03 0 2.6e-03 6.0e-03 8.3e-05 2.4e-01
13 pVTA mRNA stability Eif4a3 0.06 0.04 1.6e-03 0.02 0 0.03 -0 1.4e-02 1.9e-01 3.9e-03 8.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.90.2-0.1-0.1-0.3-0.20.1-0.10.20.20.60.31.0-0.1
Area under the delay curve0.91.12.41.11.31.21.51.00.81.00.5-0.8-0.20.8-1.41.0
BMI with tail0.41.42.8-0.8-1.7-1.7-1.4-1.4-0.6-1.1-0.71.0-1.0-1.51.00.8
BMI without tail2.47.211.7-2.5-3.4-3.4-3.2-3.1-2.2-2.8-2.22.7-2.1-2.82.6-0.6
Body weight3.214.018.2-4.0-4.3-4.3-3.9-4.2-3.9-4.1-3.83.8-3.9-3.22.2-1.8
Weight adjusted by age3.04.66.3-2.3-2.3-2.3-2.5-2.2-2.0-2.3-2.22.3-2.1-1.90.6-2.1
Bone surface0.10.20.4-0.6-0.2-0.2-0.3-0.3-0.6-0.5-0.50.2-0.40.4-0.5-0.5
Bone volume0.10.10.3-0.5-0.3-0.3-0.4-0.4-0.5-0.5-0.30.50.00.30.2-0.3
Breakpoint value in progressive ratio session0.50.62.3-0.1-1.0-0.9-0.9-0.8-0.2-0.7-0.40.7-0.4-0.21.5-0.5
Number of licking bursts0.10.20.5-0.3-0.5-0.5-0.3-0.4-0.4-0.4-0.50.3-0.6-0.20.7-0.4
Context. condit. distance diff. score0.50.61.6-0.2-0.7-0.7-0.7-0.90.0-0.40.01.0-0.7-1.21.11.3
Locomotion velocity, session 13.23.57.71.52.12.12.12.21.41.81.1-2.30.82.0-2.80.5
Locomotion distance, session 12.32.94.62.01.61.61.71.72.11.91.9-1.91.80.8-0.91.4
Locomotion velocity, session 24.95.77.92.42.72.72.52.72.22.52.2-2.82.42.4-2.20.7
Locomotion distance, session 20.60.82.51.20.60.60.50.71.30.91.2-1.01.60.40.50.4
Locomotion velocity, session 31.31.52.51.11.41.41.41.31.01.20.9-1.50.71.3-1.60.3
Locomotion distance, session 33.53.84.92.22.22.22.12.12.12.12.0-2.11.71.8-1.31.0
Stereotopy head waving bouts, day 30.20.30.70.30.50.50.70.50.30.40.3-0.50.10.9-0.70.3
Stereotopy head waving duration, day 30.20.30.70.40.40.40.60.40.60.50.5-0.60.00.9-0.30.7
Locomotion velocity, session 71.11.21.91.21.11.10.71.21.41.21.2-1.30.50.5-0.91.3
Locomotion distance, session 73.94.98.82.72.02.01.72.03.02.42.9-2.32.21.1-0.12.6
Stereotopy head waving bouts, day 70.60.71.7-0.8-0.8-0.8-0.6-1.0-0.8-0.9-0.91.2-1.3-0.60.30.1
Stereotopy head waving duration, day 70.91.12.6-1.2-1.0-1.0-0.8-1.1-1.1-1.2-1.21.2-1.6-0.50.1-0.4
Locomotion velocity, session 80.50.63.81.00.40.40.50.41.20.70.9-0.3-0.3-0.10.11.9
Locomotion distance, session 80.60.83.70.6-0.4-0.4-0.5-0.51.00.11.00.30.5-1.11.91.6
Degree of sensitization distance0.60.62.3-0.4-0.9-0.9-1.0-0.8-0.1-0.50.10.60.0-1.01.50.6
Degree of sensitization stereotypy0.70.81.7-0.7-0.9-0.9-0.8-1.1-0.7-0.9-0.81.3-1.1-0.80.70.1
Conditioned locomotion3.64.26.1-1.9-2.3-2.3-2.1-2.4-1.8-2.2-1.72.5-1.5-2.52.1-0.7
Cocaine response after cond. corrected0.10.10.30.30.40.40.20.40.40.40.4-0.30.10.3-0.50.4
Cocaine response after cond. not corrected0.70.81.10.91.11.10.81.00.90.90.8-1.00.51.1-0.90.5
Cocaine response before conditioning0.70.91.71.01.01.01.01.00.91.00.9-1.30.51.0-0.70.5
Saline control response2.23.04.1-1.9-1.9-1.9-2.0-1.9-1.8-1.9-1.81.9-1.8-1.40.7-1.0
Bone: connectivity density0.10.20.50.70.30.30.20.40.70.50.6-0.40.70.30.10.4
Bone: cortical apparent density3.04.05.62.42.12.12.22.22.22.22.2-2.32.31.6-0.71.0
Bone: cortical area6.910.615.5-3.9-3.2-3.2-3.3-3.3-3.9-3.5-3.73.5-3.2-3.20.4-2.4
Bone: cortical porosity0.70.81.9-1.1-0.6-0.6-0.6-0.6-1.3-1.0-1.20.5-0.90.50.1-1.4
Bone: cortical porosity1.11.22.3-1.4-1.0-1.0-0.9-1.0-1.5-1.2-1.50.8-1.4-0.10.1-1.2
Bone: cortical thickness6.110.215.6-3.8-3.1-3.1-3.2-3.2-4.0-3.4-3.73.5-2.7-3.10.6-2.8
Bone: cortical thickness1.92.24.3-1.7-1.4-1.4-1.4-1.5-1.7-1.5-1.61.6-1.3-2.1-0.0-1.0
Bone: cortical tissue density3.34.56.12.52.22.22.32.32.32.32.3-2.42.51.8-0.71.0
Condit. Reinf. active minus inactive responses2.32.63.8-1.7-1.8-1.8-1.7-1.8-1.6-1.7-1.51.8-1.1-1.91.2-0.9
Condit. Reinf. active-inactive response ratio1.11.22.1-1.0-1.2-1.2-1.0-1.2-1.0-1.1-0.91.4-0.6-1.51.3-0.3
Condit. Reinf. active responses3.94.86.2-2.4-2.4-2.4-2.4-2.5-2.2-2.4-2.12.3-1.5-2.51.4-1.5
Condit. Reinf. inactive responses0.81.01.6-1.1-1.1-1.1-1.3-1.1-0.9-1.2-0.90.8-0.6-1.10.3-0.9
Incentive salience index mean2.02.43.6-1.7-1.7-1.7-1.7-1.7-1.6-1.6-1.51.7-1.1-1.90.8-0.9
Condit. Reinf. lever presses0.10.10.5-0.3-0.4-0.4-0.4-0.3-0.1-0.2-0.10.3-0.0-0.70.20.1
Condit. Reinf. active minus inactive responses0.91.12.3-1.0-1.0-1.0-1.4-0.9-0.9-0.9-1.11.3-1.4-1.5-0.20.1
Condit. Reinf. active-inactive response ratio2.22.63.6-1.9-1.7-1.7-1.9-1.5-1.8-1.7-1.91.5-1.8-1.60.1-1.0
Condit. Reinf. active responses0.20.31.1-0.1-0.4-0.4-0.7-0.30.1-0.20.00.5-0.3-1.10.10.9
Condit. Reinf. inactive responses0.91.22.31.40.90.90.90.71.51.11.5-0.91.30.40.11.3
Condit. Reinf. lever presses0.40.51.70.1-0.7-0.7-0.9-0.60.4-0.30.40.40.2-1.01.31.0
Condit. Reinf. lever reinforcers received0.30.41.40.2-0.4-0.4-0.7-0.40.4-0.10.30.6-0.1-1.20.51.2
Conditioned reinforcement - actives0.10.10.50.00.00.0-0.20.20.60.20.7-0.40.7-0.0-0.10.2
Conditioned reinforcement - inactives0.71.01.6-1.3-1.2-1.2-1.1-1.1-1.2-1.1-0.81.0-0.9-1.20.4-0.2
Conditioned locomotion0.50.61.4-1.0-1.1-1.1-1.0-0.7-0.5-0.6-0.30.60.1-1.20.6-0.0
Patch foraging indifference point 0 sec0.40.84.9-0.2-1.1-1.0-0.7-0.9-0.3-0.7-0.10.70.5-0.32.2-0.4
Patch foraging indifference point AUC0.10.10.5-0.2-0.4-0.5-0.1-0.5-0.1-0.4-0.20.4-0.2-0.50.70.3
Delay disc. indifference point, 0s delay0.20.21.4-0.3-0.2-0.2-0.5-0.4-0.2-0.4-0.50.7-1.20.00.3-0.4
Delay disc. indifference point, 16s delay0.91.02.61.21.11.11.20.71.20.91.1-0.50.70.2-0.11.6
Delay disc. indifference point, 2s delay0.10.10.60.20.40.30.6-0.0-0.1-0.0-0.30.2-0.80.5-0.1-0.5
Delay disc. indifference point, 24s delay4.34.812.11.82.72.62.72.31.62.11.5-2.21.61.5-3.50.9
Delay disc. indifference point, 4s delay0.20.21.20.20.20.10.6-0.20.1-0.0-0.30.3-1.10.30.00.6
Delay disc. indifference point, 8s delay1.01.25.90.71.21.11.31.10.41.00.1-1.0-0.70.9-2.40.7
Indifference point function ln k1.01.72.61.61.11.21.11.31.51.41.6-1.41.61.50.50.6
Indifference point function log k1.01.72.61.61.11.21.11.31.51.41.6-1.41.61.50.50.6
Patch foraging total patch changes 0 sec0.51.06.5-0.2-1.2-1.0-0.8-1.0-0.2-0.70.10.80.6-0.52.5-0.2
Patch foraging total patch changes 12 sec0.50.62.2-0.4-0.9-0.9-0.4-1.0-0.6-0.9-0.40.90.5-0.31.5-0.8
Patch foraging total patch changes 18 sec0.40.63.60.5-0.6-0.50.0-0.70.6-0.20.50.50.6-0.61.90.9
Patch foraging total patch changes 24 sec1.32.23.3-1.5-1.8-1.8-1.6-1.8-1.4-1.6-1.31.8-1.2-1.51.3-0.6
Patch foraging total patch changes 6 sec0.91.33.0-1.0-1.3-1.2-0.9-1.4-1.3-1.4-1.01.00.1-0.31.4-1.7
Patch foraging time to switch 0 sec0.71.45.10.91.41.41.31.20.91.10.7-1.00.50.7-2.30.6
Patch foraging water rate 0 sec2.65.514.5-1.8-2.9-2.9-2.6-2.7-1.7-2.3-1.62.3-1.5-2.23.8-0.4
Patch foraging water rate 12 sec0.30.73.10.1-0.8-0.7-1.0-0.50.5-0.20.60.20.4-1.21.81.2
Patch foraging water rate 18 sec1.21.99.6-0.7-1.6-1.5-1.9-1.5-0.3-1.2-0.21.0-0.4-0.83.10.2
Patch foraging water rate 24 sec3.34.617.7-1.2-2.5-2.4-2.4-2.6-0.5-1.9-0.52.1-0.7-2.34.21.0
Patch foraging water rate 6 sec0.30.53.20.3-0.7-0.7-0.9-0.40.5-0.20.30.2-0.1-0.41.80.6
Seeking ratio, delayed vs. immediate footshock0.80.92.8-0.8-1.1-1.1-1.0-0.7-0.6-0.9-1.01.0-1.20.00.3-1.7
Distance traveled before self-admin1.21.62.7-0.6-1.2-1.2-1.3-1.4-1.1-1.3-1.21.5-1.6-0.41.6-1.2
Distance traveled after self-admin0.91.13.8-0.5-1.1-1.2-1.5-1.2-0.4-0.8-0.31.2-0.2-1.21.90.2
Extensor digitorum longus weight0.10.62.60.5-0.4-0.4-0.1-0.30.80.00.80.10.8-1.21.60.9
Bone: elastic displacement1.82.12.7-1.3-1.6-1.6-1.5-1.6-1.5-1.5-1.31.5-0.6-1.21.6-1.6
Bone: elastic work7.39.513.2-3.4-3.3-3.3-3.1-3.3-3.6-3.4-3.43.1-2.4-2.41.7-3.1
Bone: endosteal estimation0.10.10.70.20.20.20.30.10.50.20.4-0.2-0.0-0.1-0.20.8
Bone: endosteal perimeter0.71.53.2-1.6-1.0-1.0-0.9-1.2-1.5-1.3-1.60.8-1.8-0.8-0.6-1.0
Epididymis fat weight1.03.56.9-1.8-2.2-2.2-2.4-2.2-1.3-1.9-1.41.9-1.8-2.61.30.2
Delta time in closed arm before/after self-admin0.10.10.5-0.3-0.1-0.00.0-0.2-0.2-0.1-0.20.1-0.2-0.4-0.70.2
Delta time in open arm before/after self-admin0.70.76.00.1-0.9-0.9-0.5-0.7-0.0-0.6-0.10.40.00.32.4-0.6
Diff in mean of infusions in LGA sessions0.30.40.9-0.7-0.9-1.0-0.4-0.6-0.5-0.8-0.70.6-0.6-0.50.2-0.5
Delay discount exponential model param1.31.53.7-1.3-1.5-1.4-1.9-1.2-0.9-1.2-0.61.00.1-1.11.6-1.0
Extinction: sum of active levers before priming0.50.51.01.00.40.40.60.70.90.70.9-0.81.00.60.10.6
Active lever presses in extinction session 60.30.31.40.4-0.1-0.10.1-0.2-0.3-0.3-0.30.2-0.10.91.2-0.8
Bone: final force5.99.512.2-3.5-3.4-3.4-3.3-3.3-3.2-3.3-3.33.2-3.2-3.01.2-1.7
Bone: final moment6.811.014.1-3.8-3.6-3.6-3.6-3.6-3.5-3.6-3.53.5-3.3-3.11.6-2.0
Food consumed during 24 hour testing period0.91.32.5-1.1-1.2-1.2-1.5-1.2-1.1-1.0-0.91.0-1.1-1.61.20.5
Glucose5.58.712.92.63.53.53.63.52.23.02.1-3.42.53.4-3.10.2
Heart weight0.81.22.3-1.4-1.1-1.1-1.3-0.7-1.2-0.9-1.21.0-1.1-1.5-0.6-0.5
Delay discount hyperbolic model param1.01.23.2-1.2-1.4-1.3-1.8-1.0-0.8-1.0-0.50.80.2-1.11.3-0.8
Intermittent access intake day 1-15 change0.10.10.7-0.5-0.2-0.2-0.1-0.1-0.1-0.2-0.2-0.1-0.4-0.7-0.8-0.2
Intermittent access intake escalation0.10.10.7-0.4-0.2-0.2-0.10.0-0.0-0.1-0.1-0.2-0.2-0.7-0.8-0.2
Intermittent access intake escalation 20.30.30.6-0.7-0.6-0.6-0.5-0.2-0.4-0.4-0.50.1-0.7-0.6-0.7-0.6
Intermitt. access day 1 inactive lever presses1.24.79.3-1.9-2.4-2.4-2.2-2.5-2.0-2.3-1.82.5-1.5-2.03.1-0.4
Intermitt. access day 15 inactive lever presses0.81.74.0-0.9-1.6-1.6-1.5-1.4-0.6-1.2-0.61.6-0.8-1.52.00.5
Intermitt. access escalation Index0.60.81.3-0.5-0.9-0.9-1.1-1.0-0.7-1.0-1.00.8-0.7-0.61.0-1.1
Intermittent access day 1 total infusions0.10.10.2-0.2-0.4-0.4-0.4-0.4-0.0-0.20.20.10.4-0.10.2-0.4
Intermittent access day 15 total infusions0.30.51.1-0.9-0.9-0.9-0.7-0.7-0.4-0.7-0.30.4-0.1-1.1-0.5-0.8
Intermittent access terminal intake (last 3 days)0.50.61.1-1.0-1.0-1.0-0.9-0.7-0.5-0.8-0.40.5-0.4-1.0-0.9-0.8
Intermittent access total infusions0.20.30.6-0.6-0.8-0.8-0.6-0.5-0.1-0.5-0.10.30.0-0.7-0.5-0.5
Intermittent access day 1 locomotion0.10.20.3-0.4-0.6-0.6-0.4-0.4-0.4-0.4-0.20.20.2-0.50.2-0.4
Intermittent access day 15 total locomotion0.40.81.7-1.1-1.1-1.1-1.0-0.9-0.8-0.9-0.70.7-0.6-1.3-0.1-0.5
Intermittent access total locomotion0.40.40.9-0.8-0.9-0.9-0.7-0.7-0.6-0.6-0.40.6-0.2-0.90.1-0.3
Intermittent access standard deviation0.20.42.50.20.30.30.50.50.40.40.1-0.7-0.7-0.2-1.60.5
Left kidney weight0.10.62.4-0.9-0.4-0.4-0.5-0.6-0.9-0.8-1.10.5-1.6-0.3-1.0-0.6
Right kidney weight0.10.51.3-0.7-0.4-0.4-0.5-0.5-0.8-0.6-1.00.4-1.2-0.4-0.7-0.9
Cocaine induced anxiety1.52.23.9-1.7-1.3-1.3-1.2-1.3-1.8-1.7-2.01.3-1.8-0.6-0.2-1.9
Post-drug Anxiety0.20.30.8-0.6-0.3-0.30.1-0.5-0.9-0.6-0.80.5-0.6-0.10.1-0.4
Baseline Anxiety1.82.03.21.31.61.61.71.31.31.51.6-1.21.81.0-0.21.6
Tail length4.417.022.0-4.7-4.4-4.4-4.3-4.4-4.6-4.6-4.44.3-4.0-3.62.1-3.0
Length with tail2.912.718.9-4.2-3.5-3.5-3.3-3.6-4.4-4.0-4.33.5-4.3-2.20.8-3.2
Length without tail0.72.45.5-1.8-1.2-1.2-1.0-1.3-2.0-1.7-2.21.3-2.3-0.3-0.7-1.8
Times rat made contact with spout1.41.62.5-1.3-1.3-1.3-1.6-1.3-1.6-1.4-1.40.9-0.7-0.71.3-1.5
Lifetime Intake0.10.10.7-0.2-0.4-0.4-0.2-0.10.2-0.00.3-0.10.3-0.5-0.80.1
Liver weight, left0.30.52.20.40.90.90.70.70.40.50.3-0.80.11.5-0.9-0.4
Liver weight, right4.17.19.2-2.9-2.8-2.8-2.8-2.9-2.9-3.0-2.92.9-2.7-1.91.2-2.2
Locomotor activity0.50.81.81.00.80.80.70.81.00.91.1-0.90.81.30.30.6
Locomotor testing distance0.61.11.81.30.80.90.80.91.31.01.4-0.90.91.30.91.0
Locomotor testing rearing0.20.43.50.5-0.3-0.3-0.2-0.40.60.10.60.30.3-0.11.90.8
Locomotion in novel chamber0.20.20.7-0.4-0.5-0.5-0.4-0.7-0.3-0.4-0.20.4-0.1-0.40.8-0.1
Locomotion in novel chamber post-restriction0.91.53.0-1.7-1.2-1.2-1.3-1.1-1.6-1.3-1.31.1-0.8-1.11.0-1.0
Fecal boli incidents, locomotor time 10.60.91.81.00.50.70.41.11.11.00.9-1.21.10.6-1.3-0.0
Change in fecal boli incidents, locomotor task2.42.44.71.61.91.72.11.51.41.51.4-1.41.52.20.20.2
Time >=10cm from walls, locomotor time 10.30.31.70.70.0-0.0-0.30.10.80.30.6-0.4-0.0-0.30.81.3
Bouts of movement, locomotor time 12.12.43.91.71.41.41.71.91.61.81.4-2.01.61.2-1.50.8
Total resting periods, locomotor time 12.73.05.11.81.61.71.92.11.61.91.6-2.31.91.6-1.50.5
Rest time, locomotor task time 10.60.82.10.60.60.80.91.10.40.80.5-1.40.81.5-0.9-0.6
Distance moved, locomotor task time 10.71.01.7-1.0-0.9-1.0-1.0-1.2-0.9-1.1-0.91.3-1.1-1.30.60.0
Vertical activity count, locomotor time 10.41.13.4-0.9-0.9-0.9-1.5-1.1-0.7-0.9-0.71.2-0.8-1.90.80.3
Time >=10cm from walls, locomotor time 20.10.10.4-0.3-0.0-0.00.1-0.5-0.2-0.4-0.20.2-0.00.0-0.2-0.6
Bouts of movement, locomotor time 20.81.32.11.31.41.21.41.41.01.51.0-1.21.10.6-0.80.7
Total resting periods, locomotor time 20.50.81.41.01.10.91.01.10.81.20.8-1.00.90.2-0.70.6
Rest time, locomotor task time 20.20.32.00.00.20.20.50.60.10.40.1-0.60.3-0.1-1.40.4
Distance moved, locomotor task time 20.50.61.0-0.7-0.6-0.5-0.4-0.9-0.6-1.0-0.80.8-0.9-0.21.0-0.9
Vertical activity count, locomotor time 20.20.31.2-0.2-0.5-0.4-0.4-0.6-0.2-0.5-0.30.6-0.5-0.61.1-0.3
Light reinforcement 11.02.55.0-1.4-1.9-1.9-2.2-1.9-0.9-1.5-0.81.6-0.5-2.21.8-0.2
Light reinforcement 22.23.36.5-2.2-1.7-1.7-2.3-1.9-1.8-1.8-1.72.0-1.6-2.50.1-0.6
Bone: marrow area0.10.10.80.30.20.20.30.10.50.30.5-0.1-0.0-0.1-0.20.9
Bone: maximum diameter2.24.17.7-2.6-1.8-1.8-1.7-1.9-2.5-2.1-2.62.0-2.8-1.8-0.7-1.2
Bone: maximum force5.29.211.8-3.4-3.4-3.4-3.2-3.4-3.2-3.3-3.23.1-3.0-2.81.5-1.8
Bone: maximum moment5.910.313.1-3.6-3.6-3.6-3.4-3.6-3.4-3.5-3.43.3-3.1-2.91.8-2.1
Mean time between licks in bursts0.51.32.11.31.31.31.31.31.11.31.0-1.40.91.1-0.10.8
Mean num. licks in bursts0.20.30.6-0.6-0.5-0.5-0.8-0.5-0.6-0.5-0.30.40.2-0.60.3-0.4
Cd content in liver0.60.71.81.10.30.30.50.31.30.71.3-0.31.1-0.40.81.2
Co content in liver0.10.10.8-0.2-0.1-0.1-0.4-0.2-0.3-0.2-0.20.30.2-0.00.3-0.9
Cu content in liver0.70.81.4-1.1-0.9-0.9-1.0-0.9-1.2-0.9-1.10.8-0.8-0.50.3-1.0
Fe content in liver0.20.21.30.50.20.20.20.10.70.50.8-0.00.20.20.31.2
K content in liver1.61.52.9-1.4-1.3-1.3-1.7-1.3-1.1-1.2-1.01.4-0.8-1.70.7-0.5
Mg content in liver0.20.21.1-0.1-0.4-0.4-0.7-0.30.1-0.20.20.40.4-1.10.60.3
Mn content in liver0.10.10.4-0.4-0.2-0.2-0.3-0.4-0.4-0.3-0.40.6-0.6-0.4-0.2-0.2
Na content in liver0.00.00.1-0.1-0.0-0.0-0.20.0-0.10.0-0.00.2-0.1-0.10.20.1
Rb content in liver1.72.04.4-1.1-1.7-1.7-1.5-1.6-0.8-1.3-0.81.7-0.9-2.11.60.0
Se content in liver0.30.31.1-0.5-0.5-0.5-0.7-0.5-0.3-0.3-0.11.0-0.2-1.00.10.6
Sr content in liver0.20.20.70.00.40.40.40.4-0.20.20.0-0.40.60.7-0.1-0.8
Zn content in liver1.21.32.0-1.4-1.2-1.2-1.4-1.2-1.3-1.2-1.21.0-0.8-0.90.3-1.2
Bone: minimum diameter4.17.510.2-3.2-2.9-2.9-2.7-3.1-3.0-3.1-3.02.8-2.8-2.21.4-2.0
Time in familiar zone, hab. session 10.10.10.40.30.20.20.40.10.20.20.4-0.10.70.20.60.1
Time in novel zone, hab. session 10.10.10.7-0.2-0.1-0.1-0.3-0.1-0.0-0.1-0.20.0-0.8-0.2-0.60.5
Total zone transitions, hab. session 10.30.41.00.80.40.40.60.41.00.61.0-0.40.90.00.11.0
Total locomotion distance, hab. session 10.30.41.2-0.2-0.7-0.7-0.6-0.70.2-0.40.10.6-0.1-1.10.90.7
Locomotion velocity, hab. session 10.30.41.2-0.2-0.8-0.8-0.7-0.70.1-0.50.00.70.1-1.11.00.4
Time in familiar zone, hab. session 20.40.40.80.80.40.40.60.40.90.60.9-0.50.60.50.40.9
Time in novel zone, hab. session 20.00.00.2-0.00.20.20.00.1-0.10.1-0.10.0-0.20.1-0.5-0.2
Total zone transitions, hab. session 20.50.71.90.90.20.20.10.31.30.61.3-0.51.4-0.50.71.2
Total locomotion distance, hab. session 20.40.61.9-0.2-0.9-0.9-1.0-0.80.2-0.50.20.40.6-1.41.30.3
Locomotion velocity, hab. session 20.60.82.4-0.5-1.1-1.1-1.2-1.0-0.1-0.7-0.10.70.3-1.61.30.1
Novel to familiar place preference ratio2.02.23.0-1.4-1.7-1.7-1.7-1.6-1.5-1.5-1.21.7-0.3-1.41.7-1.5
Novelty place preference1.92.12.7-1.3-1.6-1.6-1.6-1.6-1.5-1.4-1.21.6-0.3-1.31.6-1.5
Time in novel zone, NPP test1.61.72.8-1.1-1.5-1.5-1.5-1.5-1.2-1.3-1.01.5-0.1-1.21.7-1.3
Total zone transitions, NPP test0.50.71.81.00.30.30.30.41.40.71.2-0.61.1-0.40.51.3
Total locomotion distance, NPP test0.50.73.30.4-0.5-0.5-0.6-0.50.8-0.10.80.11.1-1.01.80.7
Locomotion velocity, NPP test0.40.63.00.2-0.7-0.7-0.8-0.60.5-0.30.50.20.8-1.11.70.4
Intraocular pressure0.40.61.4-0.5-1.0-1.0-0.6-1.0-0.5-0.6-0.41.00.0-1.21.20.1
Delta distance traveled before/after self-admin0.40.41.90.00.00.0-0.10.20.70.40.9-0.01.0-0.90.01.4
Delta ambulatory time before/after self-admin0.91.12.90.70.70.70.60.91.31.11.5-0.71.7-0.2-0.41.7
Parametrial fat weight0.61.32.6-1.4-1.2-1.2-1.5-1.4-1.1-1.2-0.80.8-0.5-1.61.0-0.1
Pavlov. Cond. lever latency1.82.36.92.01.11.10.91.12.21.62.1-0.91.10.30.42.6
Pavlov. Cond. magazine entry latency2.73.55.7-2.3-1.9-1.9-1.6-1.8-2.3-2.1-2.41.6-2.3-1.20.0-1.6
Pavlov. Cond. change in total contacts0.30.31.5-0.6-0.5-0.5-0.2-0.4-0.7-0.6-0.60.30.1-0.10.1-1.2
Pavlov. Cond. index score4.25.38.6-2.9-2.3-2.3-2.0-2.2-2.9-2.6-2.92.1-2.2-1.40.5-2.4
Pavlov. Cond. latency score3.44.37.8-2.7-2.0-2.0-1.7-1.9-2.8-2.3-2.71.7-2.1-1.00.1-2.4
Pavlov. Cond. lever contacts1.41.74.7-1.7-1.2-1.2-1.0-1.1-1.8-1.5-1.70.9-0.7-0.30.3-2.2
Pavlov. Cond. magazine entry number2.53.15.52.21.71.71.41.62.32.02.3-1.52.00.80.11.8
Pavlov. Cond. intertrial magazine entries0.10.20.70.2-0.1-0.1-0.4-0.20.20.00.30.40.7-0.50.8-0.0
Pavlov. Cond. lever-magazine prob. diff.4.15.17.9-2.8-2.3-2.3-2.0-2.2-2.8-2.5-2.72.1-2.1-1.50.7-2.2
Pavlov. Cond. response bias2.22.84.9-2.1-1.6-1.6-1.3-1.5-2.2-1.9-2.21.3-1.6-0.8-0.1-2.0
Pavlov. Cond. lever latency1.01.32.70.71.41.41.61.40.41.10.3-1.20.41.5-1.6-0.4
Pavlov. Cond. magazine entry latency1.41.73.61.70.90.91.10.81.81.31.9-0.91.60.50.71.9
Pavlov. Cond. change in total contacts0.30.51.40.80.20.2-0.00.11.00.51.1-0.11.1-0.40.71.2
Pavlov. Cond. index score0.30.41.30.6-0.2-0.2-0.3-0.30.80.10.90.20.7-0.51.21.1
Pavlov. Cond. latency score0.30.41.40.5-0.2-0.2-0.3-0.30.70.10.80.30.6-0.61.11.2
Pavlov. Cond. lever contacts0.70.92.4-0.4-1.2-1.2-1.4-1.2-0.1-0.8-0.00.9-0.1-1.31.50.6
Pavlov. Cond. magazine entry number0.91.12.5-1.3-0.7-0.7-0.6-0.5-1.5-1.0-1.60.6-1.3-0.1-0.7-1.6
Pavlov. Cond. intertrial magazine entries1.42.23.0-1.5-1.6-1.6-1.7-1.6-1.4-1.6-1.51.5-1.6-1.50.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.40.51.60.80.10.1-0.0-0.01.00.41.1-0.10.9-0.30.91.3
Pavlov. Cond. response bias0.30.41.70.4-0.4-0.4-0.5-0.40.6-0.00.70.30.7-0.61.31.0
Time in closed arm before self-admin0.50.62.10.30.91.01.10.8-0.10.60.1-0.80.50.6-1.50.0
Time in closed arm after self-admin1.11.24.70.31.31.31.81.10.00.90.2-1.20.80.2-2.20.5
Time in open arm before self-admin0.10.10.4-0.00.10.0-0.5-0.2-0.1-0.1-0.10.2-0.40.1-0.7-0.5
Time in open arm after self-admin0.60.65.30.6-0.6-0.7-0.6-0.40.4-0.20.40.30.10.82.3-0.5
Bone: periosteal estimation1.83.75.6-2.4-1.9-1.9-1.9-2.1-2.2-2.1-2.22.1-2.1-2.00.1-1.1
Bone: periosteal perimeter4.17.112.2-3.4-2.3-2.3-2.3-2.5-3.5-2.9-3.52.3-3.1-1.5-0.4-2.8
Bone: post-yield work0.10.10.30.20.10.10.10.10.50.20.3-0.60.5-0.4-0.20.1
Progressive ratio test 1 active lever presses0.10.10.7-0.4-0.5-0.5-0.5-0.3-0.1-0.20.10.20.2-0.80.10.2
Progressive ratio test 1 breakpoint0.10.20.8-0.5-0.5-0.5-0.5-0.3-0.1-0.20.00.30.2-0.9-0.00.1
Progressive ratio test 1 inactive lever presses3.55.07.9-2.2-2.7-2.7-2.6-2.6-1.8-2.3-1.72.5-1.7-2.82.0-0.1
Progressive ratio test 2 active lever presses0.10.10.5-0.4-0.5-0.5-0.4-0.4-0.2-0.30.20.40.3-0.70.10.2
Progressive ratio test 2 breakpoint0.10.10.4-0.4-0.5-0.5-0.4-0.4-0.1-0.30.20.30.2-0.70.00.2
Progressive ratio test 2 inactive lever presses0.40.61.1-1.0-0.9-0.9-0.8-0.9-0.7-1.0-0.50.9-0.7-1.10.1-0.3
Incentive Sensitization - Responses0.00.00.1-0.1-0.2-0.2-0.3-0.1-0.2-0.10.10.0-0.1-0.1-0.20.1
Incentive Sensitization - Breakpoint0.00.00.1-0.1-0.2-0.2-0.3-0.1-0.1-0.10.10.0-0.1-0.1-0.20.1
Sum of active levers in priming session hrs 5-60.10.10.30.1-0.2-0.1-0.6-0.20.3-0.10.20.00.2-0.60.10.6
Progressive ratio0.71.11.91.21.11.01.11.31.21.21.0-0.91.31.4-0.10.3
Food seeking constrained by brief footshock0.30.41.20.60.30.30.40.70.90.70.4-1.10.00.5-0.50.5
Seeking ratio, punishment vs. effort0.10.20.8-0.2-0.5-0.5-0.4-0.4-0.2-0.3-0.2-0.1-0.8-0.90.10.5
Retroperitoneal fat weight4.017.327.4-4.2-4.8-4.8-4.9-4.7-3.5-4.2-3.34.4-3.7-5.23.5-0.5
Reaction time number correct0.71.45.40.3-1.1-1.0-0.8-0.91.0-0.31.00.50.4-1.22.22.3
Reaction time mean minus median0.10.20.6-0.00.50.40.50.4-0.20.3-0.1-0.50.10.5-0.8-0.4
Reaction time mean minus median AUC0.20.40.9-0.9-0.4-0.4-0.2-0.5-0.9-0.6-0.90.3-0.8-0.3-0.7-0.6
Reaction time num false alarms0.20.30.60.50.60.60.80.40.40.50.6-0.50.70.70.10.2
Reaction time num false alarms AUC0.40.61.20.80.90.91.10.60.70.70.8-0.80.91.10.10.4
Reaction time trials correct on left0.71.45.40.3-1.1-1.0-0.8-0.91.0-0.31.00.50.4-1.22.22.3
Reaction time trials on left0.81.45.50.3-1.1-1.1-0.9-0.91.0-0.31.00.50.3-1.22.32.3
Reaction time mean0.10.20.4-0.3-0.4-0.5-0.4-0.5-0.2-0.4-0.30.7-0.3-0.60.60.3
Reaction time mean AUC0.10.20.8-0.2-0.4-0.5-0.5-0.5-0.1-0.4-0.10.7-0.2-0.50.90.3
Median of all reaction times0.20.30.8-0.2-0.5-0.5-0.5-0.6-0.1-0.4-0.20.8-0.4-0.70.90.5
Reaction time omissions0.40.61.7-0.7-0.6-0.7-0.9-0.9-0.7-0.9-0.90.9-1.3-0.40.1-0.3
Reaction time false alarm rate0.81.12.50.61.41.31.41.10.20.80.3-1.00.71.6-1.0-0.8
Reaction time premature initiation rate1.41.94.81.41.51.51.81.21.31.41.5-1.32.20.70.10.9
Reaction time premature initiations1.11.94.61.40.70.81.10.61.81.11.9-0.92.2-0.11.42.1
Std. dev. reaction times0.20.40.70.70.60.50.80.50.70.70.6-0.60.50.4-0.10.6
Reaction time trials completed0.81.45.50.3-1.1-1.1-0.9-0.91.0-0.31.00.50.3-1.22.32.3
Reaction time trials AUC0.81.56.10.3-1.2-1.1-0.9-1.01.0-0.31.00.50.4-1.22.52.3
Run reversals in cocaine runway, females1.21.22.41.40.70.71.00.61.50.91.4-0.70.80.81.31.5
Run reversals in cocaine runway, males0.50.52.9-0.6-0.5-0.5-0.6-0.3-0.7-0.7-0.70.3-0.40.60.2-1.7
Latency to leave start box in cocaine runway1.11.22.01.11.41.40.61.21.31.31.3-0.91.31.1-0.00.7
Latency to leave start box in cocaine runway, F0.30.40.80.70.50.5-0.10.30.80.60.90.10.80.50.60.9
Latency to leave start box in cocaine runway, M1.11.12.10.71.41.40.71.31.01.20.9-1.41.10.9-0.40.3
Std. dev. time between licks in bursts0.81.17.7-0.1-0.9-0.9-1.3-0.9-0.3-0.5-0.20.8-0.2-1.02.80.8
Total sessions with >9 infusions0.50.61.20.70.60.60.50.91.11.01.0-1.10.70.3-0.70.8
Short access day 1 total inactive lever presses0.30.31.1-0.7-0.6-0.6-0.5-0.5-0.7-0.5-0.60.5-1.0-0.5-0.10.1
Short access day 10 total inactive lever presses2.56.08.4-2.2-2.7-2.7-2.5-2.9-2.5-2.8-2.52.6-2.5-2.02.5-0.9
Short access day 1 total infusions1.21.63.11.21.11.11.41.21.41.41.5-1.21.20.6-0.81.8
Short access day 10 total infusions0.70.91.6-1.1-1.2-1.2-1.3-0.9-1.0-1.0-0.70.7-0.5-0.90.1-0.8
Short access total infusions0.10.20.60.1-0.1-0.1-0.00.10.40.30.6-0.30.5-0.6-0.60.8
Short access day 1 locomotion0.50.71.70.40.80.80.81.00.70.90.8-1.00.60.6-1.30.7
Short access day 10 total locomotion0.20.41.20.30.60.60.50.80.20.50.1-1.00.21.1-0.6-0.9
Short access total locomotion0.30.42.20.10.60.60.30.80.30.50.2-1.10.10.4-1.5-0.3
One hour access (0.3 mA shock)0.10.20.8-0.3-0.3-0.3-0.4-0.30.2-0.00.30.30.5-0.90.10.6
Compulsive drug intake0.60.72.5-0.3-0.8-0.8-0.9-1.0-0.8-0.8-0.81.2-0.6-0.31.6-0.5
One hour access (shock baseline)0.10.21.4-0.6-0.1-0.1-0.20.10.10.00.3-0.20.4-0.6-1.20.2
Social response proportion0.10.10.30.40.0-0.00.2-0.10.40.20.3-0.10.0-0.20.40.5
Social responses0.20.31.1-0.2-0.7-0.7-0.3-0.5-0.3-0.3-0.30.7-0.4-0.41.00.3
Social time0.00.10.10.40.00.1-0.00.10.40.20.2-0.10.3-0.20.00.4
Soleus weight1.64.86.7-2.6-2.3-2.3-2.0-2.2-2.6-2.4-2.42.1-1.3-2.21.0-2.3
Bone: stiffness0.40.71.6-1.0-0.7-0.7-0.8-0.8-0.9-0.8-1.00.8-1.3-0.8-0.2-0.3
Tibialis anterior weight0.00.20.60.30.20.20.70.40.40.30.4-0.40.80.00.0-0.1
Time to tail flick, vehicle, before self-admin0.20.21.5-0.50.40.50.50.2-0.30.2-0.0-0.30.4-0.1-1.20.1
Time to tail flick, vehicle, after self-admin0.91.24.70.51.21.11.31.20.51.00.6-1.30.60.9-2.20.3
Time to tail flick, test, before self-admin0.50.61.30.80.80.81.00.90.60.70.5-1.10.61.00.0-0.1
Time to tail flick, test, after self-admin0.30.31.10.50.60.60.90.40.00.4-0.2-0.2-0.51.0-0.7-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.60.0-0.5-0.6-0.6-0.5-0.2-0.4-0.20.4-0.5-0.30.7-0.2
Delta time to tail flick, test, before/after SA0.30.31.60.20.50.50.60.40.30.50.1-0.0-0.50.3-1.30.6
Tibia length10.328.353.3-6.2-5.4-5.4-5.2-5.1-6.1-5.6-6.55.4-7.3-4.00.6-3.0
Ambulatory time before self-admin2.63.95.5-1.4-2.1-2.1-2.1-2.3-1.8-2.1-2.02.3-2.4-1.12.3-1.4
Ambulatory time after self-admin1.11.23.8-0.6-1.2-1.2-1.4-1.4-0.5-1.0-0.41.5-0.5-1.22.00.3
Bone: tissue strength2.82.85.6-1.4-2.0-2.0-1.9-1.9-1.4-1.7-1.31.8-0.8-1.42.4-1.0
Total heroin consumption0.20.20.90.0-0.6-0.5-0.9-0.30.0-0.3-0.30.2-1.0-0.20.3-0.4
Bone: trabecular number0.10.20.70.40.40.40.20.40.30.30.3-0.50.50.8-0.1-0.2
Bone: trabecular spacing0.91.33.1-0.3-1.2-1.2-1.0-1.20.2-0.60.01.4-1.1-1.81.51.5
Bone: trabecular thickness0.40.53.2-0.7-0.1-0.1-0.3-0.1-1.0-0.6-0.80.20.30.5-0.3-1.8
Bone: trabecular tissue density0.40.62.30.51.01.01.00.80.40.90.5-0.60.20.5-1.50.5
Water consumed over 24 hours0.10.10.7-0.20.00.0-0.20.1-0.4-0.1-0.1-0.30.20.5-0.0-0.8
Number of responses in last shaping day0.10.10.6-0.5-0.1-0.1-0.40.0-0.2-0.0-0.1-0.3-0.4-0.1-0.80.1