Hub : Genes

Egln3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Egln3 0.06 0.04 6.5e-04 0.03 0.02 0.03 0.03 3.4e-04 4.3e-03 1.4e-03 1.2e-03
2 Liver gene expression Egln3 0.11 0.05 8.5e-08 0.05 0.05 0.06 0.07 1.5e-06 1.2e-06 8.5e-07 7.8e-08
3 IC gene expression Egln3 0.33 0.1 0.0e+00 0.34 0.38 0.37 0.38 4.8e-15 8.2e-17 1.3e-16 7.6e-17
4 OFC gene expression Egln3 0.27 0.12 1.9e-05 0.18 0.17 0.17 0.16 4.8e-05 8.3e-05 8.7e-05 1.3e-04
5 IL gene expression Egln3 0.47 0.15 1.1e-06 0.26 0.24 0.24 -0.01 5.8e-07 1.8e-06 1.6e-06 8.3e-01
6 pVTA gene expression Egln3 0.03 0.02 3.1e-03 0.01 0.01 0.01 0.01 4.9e-02 5.7e-02 5.6e-02 8.3e-02
7 PL gene expression Egln3 0.16 0.06 1.1e-16 0.15 0.13 0.14 0.14 1.9e-16 9.3e-14 1.1e-14 2.2e-15
8 Adipose gene expression Egln3 0.37 0.11 0.0e+00 0.17 0.19 0.21 0.18 1.3e-18 3.0e-20 2.0e-22 2.2e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.78.0-1.02.80.60.8-0.9-0.40.71.6
Area under the delay curve3.43.98.4-2.91.0-1.9-2.3-1.91.5-2.21.6
BMI with tail0.20.71.90.6-0.41.00.81.4-1.10.70.2
BMI without tail0.10.40.8-0.6-0.80.0-0.60.6-0.0-0.70.9
Body weight0.20.82.1-0.7-1.0-0.8-0.8-0.20.7-0.91.5
Weight adjusted by age1.72.510.3-0.4-2.3-0.9-1.50.40.6-1.13.2
Bone surface1.11.97.6-1.22.8-0.4-0.2-1.80.6-0.21.6
Bone volume1.32.37.2-1.62.7-0.5-0.3-1.80.6-0.42.1
Breakpoint value in progressive ratio session1.01.22.8-0.01.71.31.40.3-0.90.9-1.1
Number of licking bursts0.00.10.30.3-0.4-0.20.00.10.1-0.1-0.5
Context. condit. distance diff. score0.91.13.50.2-1.9-1.0-0.80.21.1-0.6-1.4
Locomotion velocity, session 10.50.51.5-0.91.2-0.2-0.2-0.80.2-0.90.1
Locomotion distance, session 11.21.52.41.3-0.21.51.51.4-1.51.0-0.8
Locomotion velocity, session 20.10.10.5-0.3-0.10.00.00.0-0.1-0.6-0.7
Locomotion distance, session 20.71.02.50.60.51.31.30.9-1.60.8-0.0
Locomotion velocity, session 30.20.31.80.40.20.10.1-0.1-0.10.11.4
Locomotion distance, session 30.20.30.80.90.10.50.50.2-0.50.60.4
Stereotopy head waving bouts, day 31.01.14.7-1.50.7-0.5-0.7-0.70.2-0.62.2
Stereotopy head waving duration, day 30.40.52.0-0.80.80.40.30.0-0.60.21.4
Locomotion velocity, session 71.21.32.70.50.31.61.41.3-1.41.30.4
Locomotion distance, session 71.21.52.41.1-0.31.51.51.5-1.31.5-0.1
Stereotopy head waving bouts, day 70.70.84.8-1.00.50.10.0-0.2-0.10.22.2
Stereotopy head waving duration, day 70.60.73.6-0.80.90.40.2-0.2-0.40.31.9
Locomotion velocity, session 80.20.20.5-0.30.2-0.5-0.5-0.50.5-0.6-0.7
Locomotion distance, session 80.30.52.00.6-0.60.20.40.6-0.30.3-1.4
Degree of sensitization distance0.20.20.4-0.4-0.10.30.50.5-0.00.5-0.6
Degree of sensitization stereotypy0.40.41.7-1.00.5-0.3-0.2-0.60.3-0.11.3
Conditioned locomotion0.70.81.4-0.2-0.9-1.0-1.2-0.40.8-1.20.8
Cocaine response after cond. corrected0.10.20.40.6-0.70.20.20.4-0.20.3-0.3
Cocaine response after cond. not corrected1.11.32.01.1-0.41.41.41.4-1.31.30.3
Cocaine response before conditioning3.44.17.10.90.92.62.52.1-2.72.21.1
Saline control response0.71.02.6-1.0-0.8-0.9-1.0-0.20.9-0.81.6
Bone: connectivity density1.32.09.2-0.23.01.11.5-0.6-0.91.40.7
Bone: cortical apparent density0.20.31.00.6-1.00.40.20.7-0.20.2-0.7
Bone: cortical area2.53.96.2-1.8-0.1-2.5-2.5-2.02.0-2.41.2
Bone: cortical porosity0.50.51.2-0.00.1-0.7-0.9-0.90.7-1.1-0.5
Bone: cortical porosity0.40.41.0-0.1-0.0-0.7-0.9-0.70.6-1.00.1
Bone: cortical thickness0.40.71.80.3-1.3-1.1-1.0-0.30.7-0.9-0.3
Bone: cortical thickness0.20.31.10.5-1.00.1-0.10.5-0.4-0.2-0.7
Bone: cortical tissue density0.20.30.90.6-0.90.40.30.7-0.20.3-0.7
Condit. Reinf. active minus inactive responses0.80.91.9-0.20.2-1.4-1.0-1.31.3-0.8-0.0
Condit. Reinf. active-inactive response ratio0.30.30.50.5-0.2-0.7-0.6-0.60.7-0.5-0.3
Condit. Reinf. active responses1.41.83.6-0.70.4-1.8-1.4-1.91.7-1.3-0.1
Condit. Reinf. inactive responses0.20.30.9-0.50.7-0.5-0.2-1.00.4-0.3-0.4
Incentive salience index mean0.60.72.3-0.10.8-1.0-0.7-1.50.8-0.7-0.7
Condit. Reinf. lever presses0.40.62.10.41.10.40.4-0.7-0.50.1-1.5
Condit. Reinf. active minus inactive responses0.50.71.7-0.3-0.5-1.1-1.0-0.81.3-0.90.4
Condit. Reinf. active-inactive response ratio0.30.40.9-0.30.4-0.7-0.6-0.91.0-0.5-0.1
Condit. Reinf. active responses0.40.50.9-0.80.7-0.5-0.4-0.90.8-0.40.9
Condit. Reinf. inactive responses0.40.60.9-0.31.00.80.80.3-0.80.81.0
Condit. Reinf. lever presses0.71.03.3-1.21.8-0.5-0.3-1.30.6-0.01.0
Condit. Reinf. lever reinforcers received1.01.32.6-1.21.1-1.1-0.9-1.61.4-0.80.9
Conditioned reinforcement - actives0.40.70.8-0.90.9-0.8-0.6-0.90.8-0.90.7
Conditioned reinforcement - inactives0.20.30.40.30.60.60.60.4-0.60.40.4
Conditioned locomotion0.60.85.7-0.50.20.10.10.3-0.2-0.62.4
Patch foraging indifference point 0 sec2.24.09.3-3.02.8-0.9-0.9-1.90.7-0.83.0
Patch foraging indifference point AUC1.01.43.2-1.11.1-1.1-1.5-1.80.7-1.10.9
Delay disc. indifference point, 0s delay4.54.98.0-2.3-0.2-2.8-2.8-2.22.6-2.50.3
Delay disc. indifference point, 16s delay3.64.08.5-2.91.0-1.8-1.9-1.81.5-2.22.3
Delay disc. indifference point, 2s delay1.41.52.7-1.71.0-1.3-1.4-1.51.0-1.00.5
Delay disc. indifference point, 24s delay2.93.37.4-2.70.8-1.6-1.9-1.51.4-2.11.8
Delay disc. indifference point, 4s delay0.20.20.4-0.2-0.5-0.3-0.60.20.1-0.6-0.7
Delay disc. indifference point, 8s delay2.83.36.7-2.60.9-1.5-1.9-1.61.0-1.92.4
Indifference point function ln k0.10.20.8-0.90.50.10.20.2-0.0-0.00.9
Indifference point function log k0.10.20.8-0.90.50.10.20.2-0.0-0.00.9
Patch foraging total patch changes 0 sec2.54.711.2-3.33.0-1.0-1.1-2.00.8-1.03.1
Patch foraging total patch changes 12 sec0.91.23.9-0.91.5-0.4-0.4-1.30.4-0.22.0
Patch foraging total patch changes 18 sec0.50.73.7-0.60.9-0.1-0.4-0.8-0.10.11.9
Patch foraging total patch changes 24 sec0.61.03.1-1.41.6-0.0-0.3-0.7-0.1-0.41.8
Patch foraging total patch changes 6 sec0.50.82.5-0.81.6-0.1-0.2-0.90.10.01.5
Patch foraging time to switch 0 sec6.713.630.45.5-4.52.93.34.3-2.32.8-2.9
Patch foraging water rate 0 sec3.26.819.4-4.43.1-1.5-1.7-2.11.1-1.83.3
Patch foraging water rate 12 sec0.91.85.2-2.31.8-0.9-0.7-1.30.9-0.71.4
Patch foraging water rate 18 sec1.01.63.9-2.00.3-1.3-1.1-0.91.2-1.80.6
Patch foraging water rate 24 sec0.50.71.8-1.31.1-0.5-0.4-0.60.6-0.51.0
Patch foraging water rate 6 sec3.04.37.7-2.81.1-2.4-2.3-2.32.1-2.30.3
Seeking ratio, delayed vs. immediate footshock0.70.91.70.7-0.61.00.91.2-1.00.61.3
Distance traveled before self-admin0.70.92.2-0.1-1.0-1.0-0.8-0.71.5-1.00.7
Distance traveled after self-admin0.10.20.6-0.10.3-0.4-0.1-0.40.4-0.30.7
Extensor digitorum longus weight0.20.92.3-0.7-1.4-0.8-0.60.60.8-0.41.5
Bone: elastic displacement0.10.20.50.6-0.20.20.40.5-0.10.70.3
Bone: elastic work0.40.61.01.0-0.50.60.71.0-0.70.80.6
Bone: endosteal estimation3.16.811.2-3.31.4-2.7-2.8-2.92.6-2.72.2
Bone: endosteal perimeter2.96.29.4-3.11.8-2.5-2.5-3.02.3-2.42.0
Epididymis fat weight0.72.54.90.31.62.01.91.1-1.92.2-0.5
Delta time in closed arm before/after self-admin1.21.12.21.3-0.41.31.11.5-0.91.20.0
Delta time in open arm before/after self-admin1.00.92.4-0.71.6-0.6-0.4-1.40.7-0.5-1.2
Diff in mean of infusions in LGA sessions0.50.73.0-0.91.7-0.0-0.1-1.00.0-0.40.5
Delay discount exponential model param2.73.06.72.6-1.01.62.01.6-1.12.0-1.5
Extinction: sum of active levers before priming1.21.42.61.00.11.51.61.1-1.41.3-0.4
Active lever presses in extinction session 60.50.51.10.7-0.50.91.00.6-0.51.0-0.0
Bone: final force0.60.91.8-0.3-1.3-1.1-1.1-0.10.9-1.21.1
Bone: final moment1.11.72.7-0.8-1.4-1.5-1.6-0.41.3-1.71.3
Food consumed during 24 hour testing period0.60.91.5-1.0-0.3-1.2-1.0-0.40.4-1.21.2
Glucose1.32.13.3-1.6-0.3-1.8-1.8-1.01.7-1.61.2
Heart weight1.11.79.7-1.23.10.4-0.1-1.1-0.5-0.20.7
Delay discount hyperbolic model param2.12.45.42.3-1.01.41.81.4-1.01.7-1.3
Intermittent access intake day 1-15 change0.30.61.51.00.40.60.90.6-0.11.20.3
Intermittent access intake escalation0.20.41.10.80.50.70.80.6-0.21.10.3
Intermittent access intake escalation 20.91.02.31.30.61.11.30.9-0.51.50.2
Intermitt. access day 1 inactive lever presses0.10.41.10.1-0.0-0.7-0.7-1.10.7-0.80.5
Intermitt. access day 15 inactive lever presses0.51.03.5-0.41.9-0.9-0.7-1.40.7-0.60.3
Intermitt. access escalation Index0.30.41.80.6-1.30.10.20.6-0.30.4-0.8
Intermittent access day 1 total infusions0.40.61.5-1.10.5-0.5-0.5-0.70.1-1.21.1
Intermittent access day 15 total infusions0.20.31.6-0.1-0.1-0.3-0.2-0.20.3-0.41.3
Intermittent access terminal intake (last 3 days)0.50.63.4-0.50.2-0.5-0.4-0.30.5-0.61.8
Intermittent access total infusions0.30.31.4-0.50.5-0.3-0.3-0.30.1-0.81.2
Intermittent access day 1 locomotion2.63.45.9-2.10.5-1.9-1.9-2.21.5-2.41.3
Intermittent access day 15 total locomotion0.20.52.30.1-1.5-0.3-0.10.20.3-0.80.7
Intermittent access total locomotion0.70.92.6-0.9-0.5-0.8-0.9-0.60.6-1.61.1
Intermittent access standard deviation0.71.43.8-0.51.4-1.0-0.7-1.21.2-1.02.0
Left kidney weight0.62.95.7-2.11.5-1.5-1.4-2.41.7-1.80.9
Right kidney weight0.52.43.9-2.00.4-1.6-1.4-1.71.7-1.71.3
Cocaine induced anxiety0.40.51.3-1.10.4-0.6-0.6-0.70.5-0.31.1
Post-drug Anxiety1.11.22.6-1.11.4-1.0-0.9-1.61.1-0.30.6
Baseline Anxiety0.30.41.70.50.60.20.4-0.40.10.5-1.3
Tail length0.41.73.6-1.3-0.9-1.3-1.4-0.81.3-1.31.9
Length with tail0.73.35.1-1.9-0.3-1.9-1.8-1.81.9-1.82.3
Length without tail0.41.42.6-1.20.3-1.5-1.0-1.61.3-1.11.0
Times rat made contact with spout0.30.31.10.5-0.70.50.41.1-0.50.30.3
Lifetime Intake0.20.30.9-0.41.0-0.2-0.1-0.4-0.1-0.60.8
Liver weight, left0.40.71.5-0.5-0.9-1.1-0.9-0.71.2-0.8-0.4
Liver weight, right0.20.41.50.2-1.20.40.01.2-0.50.00.0
Locomotor activity0.91.54.1-1.41.4-0.9-0.7-1.20.5-0.72.0
Locomotor testing distance0.20.31.1-0.01.00.30.4-0.1-0.40.31.0
Locomotor testing rearing0.51.11.71.10.11.31.31.2-1.21.00.4
Locomotion in novel chamber1.21.64.1-0.3-1.01.10.81.8-1.50.22.0
Locomotion in novel chamber post-restriction1.01.75.9-0.62.41.01.2-0.5-0.81.01.7
Fecal boli incidents, locomotor time 10.40.52.40.4-1.6-0.00.10.90.20.20.9
Change in fecal boli incidents, locomotor task0.20.20.5-0.50.7-0.2-0.0-0.60.5-0.20.0
Time >=10cm from walls, locomotor time 10.20.21.4-0.10.00.10.00.1-0.1-0.31.2
Bouts of movement, locomotor time 11.51.74.20.2-1.2-1.8-1.5-1.32.1-0.80.0
Total resting periods, locomotor time 11.61.84.50.2-1.4-1.8-1.5-1.22.1-0.8-0.1
Rest time, locomotor task time 12.43.05.1-1.2-0.7-2.2-2.3-1.92.2-1.7-0.4
Distance moved, locomotor task time 10.40.61.00.90.31.01.00.6-0.90.7-0.6
Vertical activity count, locomotor time 10.20.41.01.00.40.80.70.3-0.60.4-0.0
Time >=10cm from walls, locomotor time 20.10.10.50.4-0.00.30.30.4-0.30.30.7
Bouts of movement, locomotor time 20.10.20.4-0.20.20.40.20.6-0.60.6-0.1
Total resting periods, locomotor time 20.10.20.4-0.10.10.40.10.7-0.60.5-0.2
Rest time, locomotor task time 20.60.81.4-1.0-1.2-1.0-1.1-0.01.0-0.90.0
Distance moved, locomotor task time 20.20.30.70.60.5-0.4-0.3-0.90.50.1-0.7
Vertical activity count, locomotor time 20.10.10.70.80.4-0.00.0-0.50.10.0-0.3
Light reinforcement 10.10.30.90.4-1.00.30.30.8-0.40.30.5
Light reinforcement 20.10.20.3-0.30.6-0.3-0.1-0.50.2-0.30.6
Bone: marrow area3.16.811.2-3.31.3-2.7-2.8-2.82.6-2.62.2
Bone: maximum diameter5.510.214.5-3.41.1-3.7-3.8-3.83.4-3.51.5
Bone: maximum force1.12.05.0-1.4-0.7-1.5-1.6-0.71.3-1.32.2
Bone: maximum moment1.72.96.2-1.8-0.7-1.9-2.0-0.91.6-1.72.5
Mean time between licks in bursts0.10.20.5-0.3-0.20.10.40.7-0.6-0.0-0.7
Mean num. licks in bursts0.30.41.1-0.10.10.80.50.8-0.80.31.0
Cd content in liver1.82.03.3-1.0-1.8-1.7-1.6-0.21.6-1.61.0
Co content in liver1.82.13.4-0.6-1.6-1.8-1.7-0.91.8-1.70.4
Cu content in liver0.91.03.60.8-1.9-0.8-0.90.10.7-0.8-1.1
Fe content in liver0.60.73.20.2-1.8-0.7-0.80.20.7-0.7-0.4
K content in liver0.80.81.91.4-1.20.70.60.9-0.50.5-0.8
Mg content in liver2.32.34.52.1-0.91.51.41.4-1.21.3-1.9
Mn content in liver1.11.33.3-1.41.8-0.7-0.8-1.60.8-0.70.3
Na content in liver1.92.13.61.9-0.01.81.51.4-1.71.5-0.7
Rb content in liver0.50.61.70.9-1.00.40.30.7-0.40.3-1.3
Se content in liver0.20.30.60.6-0.10.70.30.3-0.30.6-0.8
Sr content in liver1.11.02.40.20.91.31.40.6-0.81.50.0
Zn content in liver1.11.23.91.5-1.50.30.40.9-0.30.5-2.0
Bone: minimum diameter2.03.66.3-1.5-0.6-2.5-2.4-1.92.1-2.21.1
Time in familiar zone, hab. session 10.40.41.10.2-1.00.40.31.0-0.50.30.5
Time in novel zone, hab. session 10.70.71.8-0.30.8-0.8-0.7-1.30.7-0.6-0.9
Total zone transitions, hab. session 11.52.14.60.81.21.91.71.0-2.11.50.4
Total locomotion distance, hab. session 11.41.94.41.20.11.81.61.5-2.11.3-0.0
Locomotion velocity, hab. session 10.70.92.21.0-0.11.21.01.0-1.50.7-0.0
Time in familiar zone, hab. session 20.30.31.10.1-1.1-0.1-0.40.50.3-0.40.8
Time in novel zone, hab. session 20.40.41.1-0.81.0-0.6-0.4-1.00.3-0.3-0.4
Total zone transitions, hab. session 21.41.84.7-0.42.21.51.30.1-1.91.20.2
Total locomotion distance, hab. session 20.60.82.5-0.51.60.90.7-0.0-1.40.60.3
Locomotion velocity, hab. session 20.60.82.5-0.41.60.90.6-0.1-1.40.60.2
Novel to familiar place preference ratio0.40.52.5-0.50.70.30.4-0.1-0.20.51.6
Novelty place preference0.60.63.3-0.90.6-0.3-0.2-0.60.4-0.11.8
Time in novel zone, NPP test0.70.84.4-1.10.5-0.3-0.3-0.50.4-0.12.1
Total zone transitions, NPP test0.91.32.90.51.51.41.30.3-1.71.0-0.5
Total locomotion distance, NPP test0.50.71.9-0.21.31.00.80.0-1.40.5-0.2
Locomotion velocity, NPP test0.70.92.40.41.01.21.10.3-1.60.7-0.7
Intraocular pressure0.20.31.00.1-1.0-0.5-0.30.20.6-0.10.8
Delta distance traveled before/after self-admin0.60.71.30.51.10.70.80.4-1.11.0-0.6
Delta ambulatory time before/after self-admin0.50.61.20.60.80.60.80.5-1.11.0-0.3
Parametrial fat weight0.92.04.72.1-2.20.80.71.8-0.91.10.7
Pavlov. Cond. lever latency0.60.82.5-0.3-1.6-0.9-0.80.41.3-0.50.7
Pavlov. Cond. magazine entry latency1.11.44.10.50.81.61.40.8-2.01.0-0.3
Pavlov. Cond. change in total contacts0.80.83.4-1.21.90.50.3-0.7-0.9-0.00.6
Pavlov. Cond. index score0.91.23.30.41.31.41.20.1-1.80.8-0.7
Pavlov. Cond. latency score0.81.02.70.41.41.21.0-0.0-1.60.6-0.5
Pavlov. Cond. lever contacts0.91.12.80.51.31.31.20.2-1.70.9-0.5
Pavlov. Cond. magazine entry number1.31.64.4-0.2-1.6-1.6-1.3-0.32.1-0.90.8
Pavlov. Cond. intertrial magazine entries0.30.41.0-0.1-1.0-0.8-0.40.10.9-0.1-0.5
Pavlov. Cond. lever-magazine prob. diff.0.81.02.80.41.11.31.10.2-1.70.7-0.8
Pavlov. Cond. response bias1.11.43.60.31.61.41.20.1-1.90.9-0.6
Pavlov. Cond. lever latency1.52.03.51.5-1.11.71.61.9-1.61.10.3
Pavlov. Cond. magazine entry latency0.20.20.7-0.10.90.10.1-0.4-0.30.2-0.8
Pavlov. Cond. change in total contacts1.72.85.1-2.11.7-1.6-1.6-2.31.7-1.20.0
Pavlov. Cond. index score0.60.81.8-0.81.0-1.0-0.9-1.30.9-0.5-0.6
Pavlov. Cond. latency score0.70.92.0-0.91.1-1.0-1.0-1.40.9-0.5-0.2
Pavlov. Cond. lever contacts1.01.32.4-1.21.1-1.3-1.3-1.61.3-0.8-0.2
Pavlov. Cond. magazine entry number0.60.71.60.8-1.10.80.71.2-0.70.50.8
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.70.2-0.3-0.2-0.40.4-0.5-0.9
Pavlov. Cond. lever-magazine prob. diff.0.81.12.2-1.11.0-1.2-1.1-1.51.1-0.7-0.5
Pavlov. Cond. response bias0.81.01.8-1.01.2-1.0-0.9-1.40.9-0.6-1.0
Time in closed arm before self-admin0.60.81.30.7-0.80.91.11.0-1.11.1-0.1
Time in closed arm after self-admin2.42.53.61.7-1.91.51.71.9-1.21.7-0.1
Time in open arm before self-admin0.91.05.6-1.00.2-0.7-0.5-0.30.4-0.62.4
Time in open arm after self-admin1.71.96.9-1.52.6-0.9-0.9-1.70.5-0.90.7
Bone: periosteal estimation4.39.012.3-3.40.8-3.5-3.5-3.23.1-3.32.1
Bone: periosteal perimeter2.95.06.5-2.51.0-2.5-2.5-2.52.0-2.51.9
Bone: post-yield work0.40.62.4-1.00.6-0.5-0.4-0.40.3-0.21.5
Progressive ratio test 1 active lever presses1.31.63.5-1.90.4-1.3-1.2-1.30.9-1.61.0
Progressive ratio test 1 breakpoint1.41.73.7-1.90.5-1.3-1.1-1.31.0-1.61.0
Progressive ratio test 1 inactive lever presses0.40.61.8-0.71.2-0.3-0.8-0.6-0.3-1.40.2
Progressive ratio test 2 active lever presses0.20.30.80.40.20.50.90.6-0.70.3-0.2
Progressive ratio test 2 breakpoint0.20.20.70.30.30.50.80.5-0.70.2-0.1
Progressive ratio test 2 inactive lever presses0.40.74.2-0.12.00.60.60.0-0.90.2-0.1
Incentive Sensitization - Responses2.12.94.41.8-0.32.02.12.0-2.01.3-1.3
Incentive Sensitization - Breakpoint2.22.84.01.9-0.32.02.02.0-1.91.3-1.3
Sum of active levers in priming session hrs 5-60.60.61.21.0-1.10.60.80.7-0.20.8-0.6
Progressive ratio0.00.10.3-0.60.1-0.1-0.3-0.3-0.10.2-0.1
Food seeking constrained by brief footshock0.10.20.3-0.0-0.30.30.30.5-0.40.6-0.5
Seeking ratio, punishment vs. effort0.20.31.10.30.30.40.70.5-0.10.2-1.0
Retroperitoneal fat weight1.45.910.43.2-1.32.62.32.9-2.92.4-0.7
Reaction time number correct1.93.76.80.71.52.42.31.6-2.42.60.2
Reaction time mean minus median0.30.71.40.9-0.51.10.80.9-1.20.3-0.0
Reaction time mean minus median AUC0.20.51.20.8-0.20.90.70.7-1.10.70.1
Reaction time num false alarms1.92.79.8-2.73.10.1-0.4-1.1-0.3-0.51.7
Reaction time num false alarms AUC2.13.211.3-3.13.40.0-0.4-1.2-0.2-0.81.7
Reaction time trials correct on left1.93.76.80.71.52.42.31.6-2.42.60.2
Reaction time trials on left1.93.66.40.61.62.42.31.5-2.42.50.2
Reaction time mean0.40.61.40.8-1.20.50.20.9-0.40.3-1.1
Reaction time mean AUC0.50.81.51.0-1.20.70.51.2-0.60.6-1.0
Median of all reaction times0.40.51.60.6-1.20.30.10.8-0.20.3-1.3
Reaction time omissions0.30.41.5-0.71.2-0.4-0.5-1.00.30.10.2
Reaction time false alarm rate3.04.110.7-3.32.3-1.4-1.7-2.01.2-2.11.6
Reaction time premature initiation rate2.53.56.2-1.90.3-1.9-2.3-2.02.2-2.50.5
Reaction time premature initiations0.30.61.4-1.21.1-0.2-0.6-0.70.4-0.70.6
Std. dev. reaction times0.10.30.80.4-0.80.2-0.00.4-0.4-0.2-0.9
Reaction time trials completed1.93.66.40.61.62.42.31.5-2.42.50.2
Reaction time trials AUC1.73.26.00.61.52.32.21.5-2.32.50.2
Run reversals in cocaine runway, females0.90.93.5-0.1-1.9-1.0-0.6-0.00.9-0.8-1.1
Run reversals in cocaine runway, males0.20.20.6-0.3-0.5-0.4-0.4-0.50.1-0.80.6
Latency to leave start box in cocaine runway0.40.52.60.70.50.30.4-0.3-0.10.4-1.6
Latency to leave start box in cocaine runway, F0.10.10.40.30.30.40.4-0.2-0.10.4-0.6
Latency to leave start box in cocaine runway, M0.50.52.61.00.2-0.00.1-0.1-0.10.1-1.6
Std. dev. time between licks in bursts0.50.61.31.1-1.00.50.61.1-0.80.4-0.3
Total sessions with >9 infusions0.40.52.5-0.61.6-0.2-0.2-0.6-0.2-0.6-0.0
Short access day 1 total inactive lever presses0.10.10.4-0.20.60.2-0.30.0-0.4-0.40.3
Short access day 10 total inactive lever presses0.41.13.8-0.52.00.5-0.2-0.5-0.7-0.71.7
Short access day 1 total infusions0.50.72.6-1.01.6-0.4-0.7-0.70.1-0.80.7
Short access day 10 total infusions0.40.51.1-0.70.9-0.6-0.6-0.90.2-1.10.2
Short access total infusions0.30.42.0-0.11.40.40.4-0.0-0.8-0.10.2
Short access day 1 locomotion0.30.41.7-0.41.30.00.1-0.3-0.3-0.40.9
Short access day 10 total locomotion0.61.23.9-1.21.0-0.2-0.6-0.80.1-1.42.0
Short access total locomotion0.60.82.3-0.61.4-0.3-0.4-0.70.0-0.91.5
One hour access (0.3 mA shock)0.30.41.2-0.70.8-0.40.1-0.60.4-0.41.1
Compulsive drug intake1.21.42.8-1.20.4-1.4-1.3-1.71.4-1.20.1
One hour access (shock baseline)0.40.62.00.40.40.60.80.7-0.70.51.4
Social response proportion0.40.41.6-0.4-0.7-0.5-0.50.30.2-0.51.3
Social responses0.70.91.8-1.1-0.3-1.3-1.3-0.70.8-0.80.9
Social time0.30.50.8-0.8-0.9-0.8-0.7-0.10.4-0.70.8
Soleus weight0.72.03.2-1.00.1-1.6-1.5-1.31.7-1.51.8
Bone: stiffness0.81.32.1-1.0-1.0-1.3-1.5-0.61.1-1.31.0
Tibialis anterior weight0.31.24.4-0.8-0.0-1.1-0.8-0.61.4-0.62.1
Time to tail flick, vehicle, before self-admin1.61.62.7-1.6-0.3-1.2-1.5-0.91.3-1.61.2
Time to tail flick, vehicle, after self-admin1.92.54.6-1.30.2-2.0-1.7-1.92.2-1.8-0.0
Time to tail flick, test, before self-admin0.90.91.51.2-0.90.71.21.1-0.71.1-0.5
Time to tail flick, test, after self-admin3.03.17.0-1.3-0.7-2.3-1.9-1.72.6-1.90.2
Delta time to tail flick, vehicle, before/after SA0.40.42.10.30.2-0.5-0.1-0.40.5-0.0-1.4
Delta time to tail flick, test, before/after SA2.82.94.5-1.60.5-1.9-2.1-1.82.1-2.01.0
Tibia length1.43.96.9-1.3-0.1-2.6-2.6-2.32.2-2.40.6
Ambulatory time before self-admin0.50.71.2-0.60.1-0.8-0.7-1.01.1-1.10.8
Ambulatory time after self-admin0.10.10.7-0.20.80.20.30.0-0.20.00.5
Bone: tissue strength0.20.30.80.4-0.90.10.20.8-0.10.50.3
Total heroin consumption0.40.51.00.10.90.81.00.6-0.50.7-0.6
Bone: trabecular number1.42.37.70.12.81.51.7-0.1-1.41.70.7
Bone: trabecular spacing1.31.76.31.1-2.50.0-0.21.3-0.2-0.0-2.0
Bone: trabecular thickness2.02.55.5-1.91.7-1.0-1.0-1.81.0-1.32.3
Bone: trabecular tissue density3.34.98.5-0.3-1.8-2.7-2.9-1.82.7-2.8-1.3
Water consumed over 24 hours0.10.10.3-0.0-0.50.10.10.50.00.10.3
Number of responses in last shaping day0.20.31.10.4-0.00.30.00.5-0.60.21.1