Hub : Genes

Egln3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Egln3	0.07	0.04	3.6e-04	0.04	0.03	0.03	0.05	7.5e-05	1.1e-03	1.8e-03	2.3e-05
2	Liver	gene expression	Egln3	0.11	0.05	7.7e-08	0.06	0.06	0.05	0.07	2.8e-07	1.0e-06	1.3e-06	3.2e-08
3	IL	gene expression	Egln3	0.43	0.15	5.6e-06	0.24	0.2	0.22	0.01	1.7e-06	1.2e-05	4.0e-06	1.8e-01
4	PL	gene expression	Egln3	0.15	0.05	0.0e+00	0.16	0.14	0.14	0.16	1.1e-17	1.2e-15	4.7e-15	5.3e-17
5	OFC	gene expression	Egln3	0.22	0.09	2.6e-05	0.11	0.17	0.15	0.16	1.3e-03	8.2e-05	2.0e-04	1.7e-04
6	Adipose	gene expression	Egln3	0.36	0.1	0.0e+00	0.17	0.18	0.19	0.18	5.1e-18	3.8e-20	4.8e-21	2.8e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.1	1.9	6.4	-1.8	2.5	1.2	-0.1	0.3	-0.3
Area under the delay curve	4.2	4.5	9.5	-3.1	2.4	2.2	2.1	-1.3	-0.8
BMI with tail	0.3	1.1	1.9	0.8	-0.8	-1.4	-0.9	1.4	-0.9
BMI without tail	0.5	1.0	3.9	-1.1	0.8	-0.6	0.1	0.3	-2.0
Body weight	0.4	1.5	6.9	-1.0	0.9	-0.1	0.5	-0.4	-2.6
Weight adjusted by age	2.3	2.6	11.7	0.6	-1.0	-0.2	1.3	-0.8	-3.4
Bone surface	1.6	2.8	7.1	-2.2	2.7	2.0	0.8	-0.5	-0.4
Bone volume	1.8	3.0	6.8	-2.4	2.6	1.9	0.9	-0.7	-0.8
Breakpoint value in progressive ratio session	1.2	1.4	2.6	-0.3	1.6	-0.9	-1.5	1.3	0.9
Number of licking bursts	0.1	0.1	0.5	0.1	-0.1	-0.1	0.2	-0.3	0.7
Context. condit. distance diff. score	1.2	1.4	3.1	1.0	-1.6	-0.5	0.6	-1.2	1.8
Locomotion velocity, session 1	0.4	0.4	1.1	-1.0	0.6	0.8	-0.0	-0.6	0.2
Locomotion distance, session 1	1.1	1.5	2.8	1.0	-0.7	-1.5	-1.7	1.2	0.8
Locomotion velocity, session 2	0.2	0.2	0.8	-0.2	-0.3	-0.2	-0.4	-0.2	0.9
Locomotion distance, session 2	0.5	0.7	2.1	0.2	-0.1	-0.8	-1.5	1.2	-0.2
Locomotion velocity, session 3	0.2	0.2	1.2	0.2	-0.1	0.1	-0.2	0.2	-1.1
Locomotion distance, session 3	0.2	0.2	0.4	0.4	-0.1	-0.3	-0.6	0.6	-0.4
Stereotopy head waving bouts, day 3	0.9	1.1	2.5	-1.4	1.1	0.7	0.5	-0.4	-1.6
Stereotopy head waving duration, day 3	0.4	0.4	1.0	-1.0	1.0	0.4	0.0	0.2	-0.6
Locomotion velocity, session 7	0.7	0.8	1.8	0.3	0.3	-1.1	-1.4	1.2	-0.2
Locomotion distance, session 7	0.6	0.7	1.5	0.5	-0.0	-1.2	-1.2	1.1	-0.1
Stereotopy head waving bouts, day 7	1.0	1.2	2.6	-1.6	1.5	0.5	0.3	-0.3	-1.3
Stereotopy head waving duration, day 7	0.6	0.7	1.7	-1.0	1.0	0.2	-0.5	0.5	-1.3
Locomotion velocity, session 8	0.2	0.3	1.1	-0.2	-0.3	0.2	0.0	-0.5	1.0
Locomotion distance, session 8	0.7	1.1	2.9	1.0	-1.3	-0.8	-0.7	-0.1	1.7
Degree of sensitization distance	0.1	0.1	0.7	-0.1	0.1	-0.2	0.0	-0.3	0.8
Degree of sensitization stereotypy	0.5	0.6	1.3	-1.2	1.1	0.5	0.2	-0.4	-0.8
Conditioned locomotion	1.1	1.3	5.6	-0.2	-0.6	0.2	0.8	-1.0	-2.4
Cocaine response after cond. corrected	0.2	0.2	0.4	0.4	-0.3	-0.5	-0.3	0.2	0.7
Cocaine response after cond. not corrected	1.1	1.2	2.3	0.4	0.3	-1.5	-1.5	1.4	0.4
Cocaine response before conditioning	2.7	3.3	8.0	-0.0	1.4	-1.9	-2.5	2.8	-0.3
Saline control response	0.7	1.0	1.9	-1.0	0.8	0.6	1.4	-1.1	-0.9
Bone: connectivity density	1.2	1.8	6.3	-1.4	2.5	0.7	-1.0	0.7	0.7
Bone: cortical apparent density	0.2	0.3	0.9	0.7	-0.9	-0.6	-0.1	-0.0	0.2
Bone: cortical area	2.2	3.3	6.0	-1.4	0.9	2.2	2.5	-2.4	-0.9
Bone: cortical porosity	0.5	0.5	1.2	0.2	-0.3	1.1	1.1	-0.5	-0.4
Bone: cortical porosity	0.4	0.4	0.9	0.5	-0.6	0.8	0.9	-0.4	-0.5
Bone: cortical thickness	0.5	0.8	1.9	0.6	-1.0	0.4	0.9	-1.4	-0.4
Bone: cortical thickness	0.2	0.2	0.9	0.7	-0.9	-0.1	0.1	-0.2	-0.2
Bone: cortical tissue density	0.2	0.3	0.8	0.7	-0.9	-0.6	-0.2	0.0	0.3
Condit. Reinf. active minus inactive responses	0.7	0.8	1.9	-0.2	0.2	1.1	1.0	-1.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.5	-0.4	0.4	0.8	-0.6	0.0
Condit. Reinf. active responses	1.4	1.7	4.8	-0.5	0.2	1.6	1.2	-2.2	0.9
Condit. Reinf. inactive responses	0.4	0.5	1.5	-0.2	0.1	0.7	-0.2	-1.0	1.2
Incentive salience index mean	0.6	0.7	1.8	0.0	-0.0	1.4	0.7	-1.0	1.1
Condit. Reinf. lever presses	0.4	0.6	2.4	0.5	-0.4	0.7	-0.2	0.3	1.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.8	-0.4	0.2	0.7	1.3	-1.0	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.4	0.3	0.6	0.5	-0.5	0.4
Condit. Reinf. active responses	0.7	0.9	1.5	-1.1	1.1	1.1	1.2	-0.6	0.0
Condit. Reinf. inactive responses	0.3	0.3	1.2	-0.5	1.1	0.1	-0.3	0.6	-0.2
Condit. Reinf. lever presses	1.1	1.5	3.6	-1.6	1.9	1.5	0.6	-0.2	0.0
Condit. Reinf. lever reinforcers received	1.2	1.7	2.9	-1.3	1.3	1.7	1.6	-1.1	0.3
Conditioned reinforcement - actives	1.8	1.8	2.8	-1.1	0.4	1.5	1.5	-1.7	-1.3
Conditioned reinforcement - inactives	0.2	0.3	0.5	-0.6	0.7	0.2	0.3	-0.7	-0.3
Conditioned locomotion	1.5	1.8	9.2	-0.8	0.7	0.4	0.3	-0.1	-3.0
Patch foraging indifference point 0 sec	3.5	5.6	13.8	-3.5	3.7	2.0	1.1	-0.2	-1.5
Patch foraging indifference point AUC	0.8	0.9	2.9	-0.7	0.4	1.7	1.3	-0.5	-0.3
Delay disc. indifference point, 0s delay	3.7	4.1	7.5	-1.8	0.5	2.4	2.7	-2.7	0.4
Delay disc. indifference point, 16s delay	3.6	3.7	6.4	-2.5	1.6	1.9	2.1	-1.5	-1.6
Delay disc. indifference point, 2s delay	1.8	1.9	3.8	-1.9	1.8	1.5	1.3	-0.9	0.3
Delay disc. indifference point, 24s delay	3.6	3.4	6.8	-2.6	1.9	1.8	1.9	-1.4	-1.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.9	-0.4	0.0	-0.0	0.6	-0.2	1.0
Delay disc. indifference point, 8s delay	3.2	3.3	6.7	-2.6	2.1	1.7	1.7	-0.8	-1.6
Indifference point function ln k	0.3	0.5	1.4	-1.1	1.2	-0.2	-0.3	-0.0	-0.1
Indifference point function log k	0.3	0.5	1.4	-1.1	1.2	-0.2	-0.3	-0.0	-0.1
Patch foraging total patch changes 0 sec	3.9	6.2	14.8	-3.7	3.9	2.2	1.3	-0.3	-1.6
Patch foraging total patch changes 12 sec	0.6	0.8	2.0	-0.7	1.1	1.0	0.3	0.0	-1.4
Patch foraging total patch changes 18 sec	0.8	1.0	2.3	-0.9	1.3	0.8	0.1	0.7	-1.5
Patch foraging total patch changes 24 sec	0.7	0.9	2.1	-1.3	1.4	0.7	0.2	0.3	-0.9
Patch foraging total patch changes 6 sec	0.6	0.9	3.0	-1.1	1.7	1.0	0.3	0.4	0.2
Patch foraging time to switch 0 sec	9.1	14.1	28.3	5.3	-4.9	-4.5	-3.0	1.7	0.6
Patch foraging water rate 0 sec	5.8	9.3	22.3	-4.7	4.6	2.3	1.7	-0.7	-2.0
Patch foraging water rate 12 sec	1.3	2.0	4.8	-2.1	2.2	1.4	0.5	-0.7	0.5
Patch foraging water rate 18 sec	1.2	1.5	3.5	-1.9	1.4	1.0	1.2	-1.2	-0.1
Patch foraging water rate 24 sec	0.9	1.2	4.2	-1.7	2.1	0.4	-0.0	-0.3	-0.1
Patch foraging water rate 6 sec	2.3	3.3	5.0	-2.2	1.5	2.1	1.9	-2.0	0.9
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	5.0	0.9	-0.8	-1.1	-0.6	0.9	-2.2
Distance traveled before self-admin	0.4	0.4	1.5	0.3	-0.7	-0.2	0.2	-1.2	-0.3
Distance traveled after self-admin	0.6	0.6	2.1	-1.0	1.5	0.4	0.2	-0.4	-0.5
Extensor digitorum longus weight	0.2	0.9	2.0	-0.5	0.3	-1.3	0.1	-1.1	-1.4
Bone: elastic displacement	0.3	0.3	0.8	0.9	-0.3	-0.7	-0.6	0.3	-0.2
Bone: elastic work	0.6	0.7	1.5	1.2	-0.6	-1.0	-0.8	0.6	-0.8
Bone: endosteal estimation	2.7	6.0	9.3	-3.1	2.5	2.8	2.8	-2.0	-0.8
Bone: endosteal perimeter	2.5	5.3	8.4	-2.8	2.4	2.9	2.5	-1.7	-0.3
Epididymis fat weight	0.4	0.9	3.6	0.2	0.6	-0.9	-0.6	1.9	-0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.8	-0.6	-0.3	-0.3	-0.1	0.1
Delta time in open arm before/after self-admin	0.8	0.8	1.4	-1.1	1.2	0.9	0.4	-0.1	1.0
Diff in mean of infusions in LGA sessions	1.1	1.2	2.1	-1.3	1.3	0.9	0.8	-0.6	-1.4
Delay discount exponential model param	3.4	3.5	8.1	2.8	-2.3	-1.8	-1.7	0.9	0.8
Extinction: sum of active levers before priming	0.7	0.7	1.5	0.6	0.0	-0.9	-1.2	1.2	-0.7
Active lever presses in extinction session 6	0.6	0.6	1.1	1.1	-1.0	-0.7	-0.8	0.1	-0.5
Bone: final force	0.5	0.8	2.5	-0.0	-0.3	0.4	1.6	-1.0	-0.9
Bone: final moment	0.8	1.2	3.7	-0.3	-0.2	0.7	1.9	-1.3	-1.2
Food consumed during 24 hour testing period	0.6	0.7	1.2	-0.8	0.4	0.6	1.1	-1.0	-1.0
Glucose	0.5	0.8	1.8	-0.9	0.7	0.7	1.0	-1.4	-0.1
Heart weight	1.3	1.9	5.6	-1.9	2.4	0.7	0.3	0.9	-0.7
Delay discount hyperbolic model param	2.7	2.8	6.5	2.5	-2.1	-1.6	-1.6	0.9	0.4
Intermittent access intake day 1-15 change	0.8	0.8	2.0	0.6	0.8	-0.8	-1.4	0.8	0.6
Intermittent access intake escalation	1.0	1.0	2.8	0.9	0.6	-1.1	-1.7	0.8	0.5
Intermittent access intake escalation 2	2.2	2.1	4.9	1.3	0.4	-1.6	-2.2	1.4	1.2
Intermitt. access day 1 inactive lever presses	2.4	2.6	5.1	-0.9	-0.1	1.8	2.0	-1.6	-2.3
Intermitt. access day 15 inactive lever presses	1.5	1.6	3.4	-1.4	1.2	1.8	1.3	-1.1	-0.2
Intermitt. access escalation Index	1.0	0.9	1.9	1.1	-0.7	-1.4	-1.0	0.6	0.1
Intermittent access day 1 total infusions	0.7	0.8	4.0	-0.5	-0.1	0.4	0.6	-0.5	-2.0
Intermittent access day 15 total infusions	0.4	0.4	2.1	0.3	-0.1	-0.2	-0.3	-0.3	-1.4
Intermittent access terminal intake (last 3 days)	0.4	0.5	2.7	-0.0	0.2	-0.1	-0.1	-0.4	-1.7
Intermittent access total infusions	0.4	0.5	2.5	0.2	-0.2	-0.4	-0.3	0.1	-1.6
Intermittent access day 1 locomotion	2.0	2.1	4.8	-1.1	0.0	1.5	1.7	-1.2	-2.2
Intermittent access day 15 total locomotion	0.5	0.6	1.1	0.6	-1.0	0.1	0.6	-0.9	-0.9
Intermittent access total locomotion	0.9	1.0	4.0	0.2	-0.9	0.2	0.6	-0.7	-2.0
Intermittent access standard deviation	0.2	0.2	0.7	-0.2	0.9	0.3	-0.0	-0.3	-0.4
Left kidney weight	0.2	0.6	1.3	-1.1	1.1	0.5	0.4	-0.2	-0.9
Right kidney weight	0.3	0.7	1.3	-1.1	0.9	0.6	0.7	-0.4	-1.1
Cocaine induced anxiety	0.4	0.5	1.1	-1.0	1.1	0.4	0.4	0.1	-0.5
Post-drug Anxiety	1.2	1.3	2.2	-1.4	1.0	1.5	1.3	-1.1	0.4
Baseline Anxiety	0.3	0.3	0.9	0.6	-0.6	-0.2	-0.5	0.4	0.9
Tail length	0.9	2.7	6.9	-1.9	1.7	0.9	1.0	-0.9	-2.6
Length with tail	0.9	3.5	10.8	-1.6	1.5	0.9	1.2	-1.7	-3.3
Length without tail	0.2	0.5	1.7	0.7	-0.8	-0.3	0.0	-0.5	-1.3
Times rat made contact with spout	0.4	0.5	1.1	0.5	-0.3	-1.1	-0.5	0.2	-1.0
Lifetime Intake	0.3	0.4	1.5	0.3	-0.1	-0.5	-0.6	0.4	-1.2
Liver weight, left	0.1	0.2	1.1	0.1	0.0	0.1	0.4	-0.1	1.0
Liver weight, right	0.4	0.6	1.6	0.5	-0.9	-0.4	0.7	-0.7	-1.3
Locomotor activity	1.3	2.1	4.5	-2.0	2.1	1.4	0.8	-0.3	-1.1
Locomotor testing distance	0.6	1.0	3.4	-1.3	1.9	0.4	-0.1	0.4	-0.7
Locomotor testing rearing	0.6	0.9	1.9	0.6	0.0	-1.2	-1.2	1.4	-0.5
Locomotion in novel chamber	1.1	1.4	5.7	0.3	-0.8	-1.0	-0.2	0.9	-2.4
Locomotion in novel chamber post-restriction	1.3	1.6	3.6	-1.3	1.9	0.4	-0.7	0.7	-1.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.5	-0.2	-0.8	-0.2	-0.3	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.3	0.1	0.3	0.3	-0.3	-0.1
Time >=10cm from walls, locomotor time 1	0.6	0.6	3.3	-0.2	-0.4	0.0	0.3	0.0	-1.8
Bouts of movement, locomotor time 1	1.3	1.5	4.2	0.3	-1.1	1.2	1.3	-2.0	-0.3
Total resting periods, locomotor time 1	1.3	1.4	4.3	0.5	-1.2	1.0	1.2	-2.1	0.0
Rest time, locomotor task time 1	2.6	2.9	6.6	-0.7	-0.2	1.9	2.3	-2.6	1.1
Distance moved, locomotor task time 1	0.4	0.5	0.7	0.7	-0.8	-0.5	-0.8	0.8	0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.4	-0.5	-0.3	-0.6	0.7	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	1.0	0.1	-0.2	0.1	-0.1	0.5	-1.0
Bouts of movement, locomotor time 2	0.3	0.3	0.5	-0.3	0.7	-0.4	-0.5	0.6	0.5
Total resting periods, locomotor time 2	0.3	0.3	0.7	-0.4	0.8	-0.4	-0.4	0.7	0.5
Rest time, locomotor task time 2	0.3	0.4	1.0	-0.5	0.2	0.3	1.0	-1.0	0.1
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.2	-0.4	0.8	0.2	-0.4	0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.6	0.4	-0.8	0.3	-0.0	-0.0	0.1
Light reinforcement 1	0.2	0.4	1.4	0.5	-0.4	-0.6	-0.2	0.1	-1.2
Light reinforcement 2	0.1	0.2	0.5	0.2	-0.5	0.6	0.2	-0.0	-0.7
Bone: marrow area	2.8	6.0	9.3	-3.1	2.6	2.8	2.8	-1.9	-0.9
Bone: maximum diameter	4.8	8.7	15.1	-2.8	1.9	3.9	3.8	-3.2	-0.6
Bone: maximum force	1.0	1.8	3.9	-0.9	0.6	0.8	1.8	-1.3	-2.0
Bone: maximum moment	1.4	2.4	4.8	-1.2	0.7	1.0	2.1	-1.6	-2.2
Mean time between licks in bursts	0.2	0.3	0.7	0.4	-0.7	-0.7	-0.5	0.0	0.8
Mean num. licks in bursts	0.5	0.6	2.1	-0.1	0.4	-0.6	-0.6	0.6	-1.4
Cd content in liver	0.4	0.4	1.6	0.7	-0.3	-1.3	-0.3	-0.4	-0.4
Co content in liver	0.7	0.9	3.2	0.0	-0.2	0.7	1.2	-1.8	0.0
Cu content in liver	0.5	0.6	1.4	0.3	-0.4	-0.0	1.2	-0.9	1.0
Fe content in liver	0.3	0.3	1.1	-0.3	-0.1	0.1	0.7	-1.1	-0.5
K content in liver	1.1	1.1	3.1	1.5	-1.8	-0.3	-0.2	0.5	0.8
Mg content in liver	2.6	2.7	5.6	2.4	-2.3	-1.1	-0.9	1.1	1.5
Mn content in liver	2.3	2.6	5.2	-2.3	1.6	2.1	1.6	-1.0	-0.5
Na content in liver	1.3	1.3	3.6	1.4	-0.7	-0.7	-1.2	1.9	0.3
Rb content in liver	1.2	1.5	3.2	1.8	-1.4	-0.9	-0.9	0.2	1.4
Se content in liver	0.5	0.7	2.2	1.1	-1.5	-0.5	0.0	0.6	0.1
Sr content in liver	1.5	1.4	4.3	0.9	-0.6	-1.1	-2.1	1.0	0.6
Zn content in liver	2.6	2.9	5.6	2.4	-2.3	-1.0	-0.6	0.3	2.3
Bone: minimum diameter	1.6	2.9	6.1	-1.5	1.0	1.9	2.5	-2.1	-0.4
Time in familiar zone, hab. session 1	0.4	0.3	1.0	0.3	-0.3	-0.9	-0.4	0.3	-1.0
Time in novel zone, hab. session 1	0.6	0.6	1.4	-0.5	0.2	1.2	0.5	-0.7	1.1
Total zone transitions, hab. session 1	1.2	1.7	4.1	0.1	0.2	-0.8	-2.0	2.0	-1.3
Total locomotion distance, hab. session 1	1.0	1.4	3.1	0.7	-0.4	-1.1	-1.8	1.6	-0.9
Locomotion velocity, hab. session 1	0.5	0.7	1.1	0.6	-0.6	-0.6	-1.0	1.1	-0.9
Time in familiar zone, hab. session 2	0.4	0.4	1.8	-0.3	0.3	-0.1	0.7	0.2	-1.4
Time in novel zone, hab. session 2	0.4	0.4	1.3	-0.3	0.1	0.6	-0.2	-0.8	1.1
Total zone transitions, hab. session 2	1.0	1.3	2.9	-0.7	1.1	0.2	-1.6	1.7	-0.7
Total locomotion distance, hab. session 2	0.5	0.6	1.1	-0.7	0.8	0.6	-0.4	1.0	-0.9
Locomotion velocity, hab. session 2	0.5	0.6	1.2	-0.6	0.7	0.7	-0.3	1.0	-1.1
Novel to familiar place preference ratio	0.2	0.2	0.6	-0.3	0.8	-0.3	-0.7	0.2	-0.4
Novelty place preference	0.2	0.2	0.7	-0.6	0.8	0.1	-0.1	-0.4	-0.5
Time in novel zone, NPP test	0.4	0.4	0.9	-0.7	1.0	0.0	-0.2	-0.4	-0.7
Total zone transitions, NPP test	0.4	0.6	1.8	0.0	0.1	0.3	-1.2	1.3	-0.4
Total locomotion distance, NPP test	0.3	0.4	0.6	-0.6	0.5	0.7	-0.4	0.8	-0.6
Locomotion velocity, NPP test	0.2	0.2	0.9	-0.0	0.0	0.5	-0.4	1.0	-0.2
Intraocular pressure	0.1	0.1	0.4	0.1	-0.3	-0.3	0.2	-0.7	-0.3
Delta distance traveled before/after self-admin	0.7	0.7	2.3	-0.8	1.5	0.5	-0.3	1.0	0.3
Delta ambulatory time before/after self-admin	0.6	0.7	2.3	-0.8	1.5	0.4	-0.3	0.9	-0.2
Parametrial fat weight	0.6	1.1	3.0	0.9	-0.1	-1.7	-1.0	1.2	-0.7
Pavlov. Cond. lever latency	0.3	0.4	1.3	0.2	-0.1	-1.0	0.2	-1.2	-0.4
Pavlov. Cond. magazine entry latency	1.0	1.3	3.8	1.0	-0.8	-0.5	-1.3	1.9	-0.6
Pavlov. Cond. change in total contacts	0.5	0.5	0.9	-0.9	0.8	1.0	0.1	0.5	-0.6
Pavlov. Cond. index score	0.5	0.7	2.7	0.6	-0.6	0.3	-0.7	1.6	0.1
Pavlov. Cond. latency score	0.4	0.5	2.1	0.4	-0.5	0.5	-0.6	1.5	-0.0
Pavlov. Cond. lever contacts	0.5	0.5	2.3	0.5	-0.5	0.1	-0.6	1.5	0.3
Pavlov. Cond. magazine entry number	0.8	1.0	3.9	-0.5	0.4	-0.1	1.2	-2.0	0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.9	0.0	-0.1	-0.3	0.3	-1.2	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	2.3	0.6	-0.7	0.1	-0.6	1.5	0.2
Pavlov. Cond. response bias	0.8	1.0	3.6	0.8	-0.8	-0.0	-1.1	1.9	-0.1
Pavlov. Cond. lever latency	1.5	2.0	3.6	1.5	-1.3	-1.9	-1.5	1.3	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	-0.1	0.1	0.4	-0.3	0.6	0.9
Pavlov. Cond. change in total contacts	1.7	2.4	5.0	-1.7	1.3	2.2	1.7	-1.4	0.2
Pavlov. Cond. index score	0.5	0.6	1.6	-0.6	0.5	1.3	0.8	-0.6	0.7
Pavlov. Cond. latency score	0.6	0.7	2.0	-0.9	0.7	1.4	0.9	-0.6	0.2
Pavlov. Cond. lever contacts	0.8	1.1	2.5	-0.9	0.7	1.6	1.3	-1.0	0.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.6	0.6	-0.3	-1.2	-0.6	0.4	-1.3
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.7	-0.7	0.4	0.5	0.5	-0.9	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.8	-0.8	0.6	1.3	0.9	-0.8	0.8
Pavlov. Cond. response bias	0.7	0.9	2.0	-0.8	0.5	1.4	1.0	-0.7	1.1
Time in closed arm before self-admin	1.3	1.4	3.0	0.9	-0.4	-1.7	-1.4	1.6	-0.2
Time in closed arm after self-admin	1.8	1.8	3.5	1.7	-1.6	-1.9	-1.3	0.6	0.3
Time in open arm before self-admin	1.8	1.9	5.8	-1.2	1.1	1.0	1.0	-1.0	-2.4
Time in open arm after self-admin	3.1	3.4	6.7	-2.4	2.6	2.2	1.4	-0.5	-1.1
Bone: periosteal estimation	3.6	7.4	11.6	-2.8	2.1	3.2	3.4	-2.9	-1.1
Bone: periosteal perimeter	2.3	3.8	5.9	-2.2	1.9	2.4	2.2	-1.6	-0.8
Bone: post-yield work	0.7	1.0	2.2	-1.1	1.5	0.7	0.6	-0.2	-1.2
Progressive ratio test 1 active lever presses	0.8	0.8	3.0	-0.6	0.0	0.5	0.8	-0.7	-1.7
Progressive ratio test 1 breakpoint	0.9	1.0	3.1	-0.7	0.0	0.8	1.0	-0.9	-1.8
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.7	-0.8	0.2	1.2	1.3	-0.7	-1.6
Progressive ratio test 2 active lever presses	0.6	0.7	1.1	0.7	-0.3	-1.0	-1.1	0.8	-0.8
Progressive ratio test 2 breakpoint	0.6	0.6	1.1	0.5	-0.1	-1.0	-1.0	0.8	-0.9
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.7	-0.6	1.3	0.3	-0.5	0.7	-0.4
Incentive Sensitization - Responses	2.3	2.3	4.3	1.5	-0.7	-2.1	-1.8	1.8	-0.1
Incentive Sensitization - Breakpoint	2.0	2.1	3.9	1.5	-0.7	-2.0	-1.7	1.7	0.0
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.5	1.6	-1.0	-1.1	-1.0	0.2	0.5
Progressive ratio	0.1	0.1	0.3	-0.3	0.1	0.0	0.2	0.2	-0.6
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.3	-0.1	-0.7	-0.5	0.5	0.2
Seeking ratio, punishment vs. effort	0.3	0.3	1.2	0.1	0.3	-0.4	-0.6	0.3	1.1
Retroperitoneal fat weight	1.9	6.3	11.1	3.3	-2.5	-3.2	-2.1	2.3	0.1
Reaction time number correct	2.7	3.9	8.4	0.0	1.4	-2.2	-2.6	2.9	0.9
Reaction time mean minus median	0.4	0.6	1.6	0.4	-0.8	-0.6	-0.7	1.3	-0.4
Reaction time mean minus median AUC	0.3	0.4	1.9	0.1	-0.3	-0.4	-0.6	1.4	-0.1
Reaction time num false alarms	2.9	4.0	12.2	-3.1	3.5	1.3	0.1	0.6	-0.4
Reaction time num false alarms AUC	3.4	4.7	14.3	-3.4	3.8	1.3	0.1	0.7	-0.5
Reaction time trials correct on left	2.7	3.9	8.4	0.0	1.4	-2.2	-2.6	2.9	0.9
Reaction time trials on left	2.7	3.8	8.4	-0.1	1.6	-2.1	-2.6	2.9	0.9
Reaction time mean	0.1	0.2	0.6	0.2	-0.6	-0.3	0.1	0.3	0.7
Reaction time mean AUC	0.2	0.3	0.5	0.4	-0.7	-0.6	-0.2	0.5	0.6
Median of all reaction times	0.2	0.3	1.0	0.3	-0.5	-0.4	0.1	0.2	1.0
Reaction time omissions	0.6	0.8	1.8	-1.3	1.2	1.2	0.2	0.4	-0.2
Reaction time false alarm rate	3.4	4.7	10.0	-3.2	2.7	2.5	1.7	-1.0	-0.9
Reaction time premature initiation rate	2.4	3.2	5.7	-1.3	0.0	2.3	2.0	-2.4	-1.5
Reaction time premature initiations	0.4	0.6	1.3	-1.1	0.8	0.6	0.2	-0.4	-1.0
Std. dev. reaction times	0.1	0.2	0.4	-0.1	-0.6	0.1	0.2	0.3	0.7
Reaction time trials completed	2.7	3.8	8.4	-0.1	1.6	-2.1	-2.6	2.9	0.9
Reaction time trials AUC	2.5	3.7	7.5	-0.2	1.7	-2.1	-2.5	2.7	0.9
Run reversals in cocaine runway, females	1.4	1.3	4.3	0.9	-2.1	0.2	1.1	-1.2	0.3
Run reversals in cocaine runway, males	0.2	0.2	0.9	0.1	-0.2	0.0	0.4	-0.3	-1.0
Latency to leave start box in cocaine runway	0.4	0.5	2.7	0.1	0.2	0.4	0.0	-0.0	1.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	-0.6	-0.1	0.5	0.5	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.4	0.4	0.8	-0.1	0.7	0.9	0.4	-0.1	0.9
Std. dev. time between licks in bursts	0.9	1.1	2.2	1.4	-1.5	-1.2	-0.6	0.5	-0.2
Total sessions with >9 infusions	0.5	0.5	1.0	-0.6	0.2	1.0	0.8	-0.9	-0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.6	0.0	0.3	-0.1	-0.1	-0.1	-0.8
Short access day 10 total inactive lever presses	1.6	1.7	2.3	-1.5	1.4	1.5	1.5	0.1	-1.3
Short access day 1 total infusions	0.1	0.1	0.3	-0.2	0.6	0.2	0.1	-0.1	-0.4
Short access day 10 total infusions	0.2	0.3	1.3	-0.4	0.1	0.2	0.2	-0.3	-1.2
Short access total infusions	0.3	0.4	0.9	0.2	0.3	-0.5	-0.8	1.0	-0.6
Short access day 1 locomotion	0.1	0.1	0.3	0.2	0.3	-0.1	-0.3	0.6	-0.6
Short access day 10 total locomotion	1.1	1.3	5.4	-0.9	0.9	0.4	0.6	0.1	-2.3
Short access total locomotion	0.6	0.7	2.8	-0.5	0.5	0.6	0.5	-0.0	-1.7
One hour access (0.3 mA shock)	0.3	0.4	1.3	-0.3	0.3	0.2	0.0	-0.8	-1.2
Compulsive drug intake	0.9	0.9	1.4	-1.1	0.5	1.1	1.2	-1.1	0.1
One hour access (shock baseline)	0.7	0.8	3.1	0.4	0.1	-0.7	-0.9	0.7	-1.8
Social response proportion	0.7	0.8	3.9	-0.1	0.6	-0.4	0.4	-0.1	-2.0
Social responses	0.7	0.9	1.7	-0.8	0.8	0.7	1.3	-0.6	-1.2
Social time	0.4	0.5	1.7	-0.7	0.4	0.0	0.4	-0.5	-1.3
Soleus weight	0.8	2.3	8.5	-0.3	-0.3	0.7	1.1	-1.8	-2.9
Bone: stiffness	0.7	1.1	2.7	-0.4	-0.1	0.7	1.6	-1.4	-1.1
Tibialis anterior weight	0.5	1.8	5.2	-1.3	1.4	-0.2	0.2	-1.4	-2.3
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.0	-0.9	-0.1	1.0	1.7	-1.7	-0.9
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.2	-0.8	0.4	1.1	0.8	-1.5	1.3
Time to tail flick, test, before self-admin	0.6	0.6	1.2	0.5	-0.2	-1.1	-1.1	0.7	0.5
Time to tail flick, test, after self-admin	2.6	2.6	8.4	-1.1	-0.2	1.6	1.9	-2.9	0.1
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	4.2	0.5	0.1	-0.2	-0.8	0.4	2.0
Delta time to tail flick, test, before/after SA	2.4	2.2	4.8	-1.1	0.3	1.6	2.0	-2.2	-0.7
Tibia length	0.7	2.0	3.9	-0.8	0.4	1.9	1.9	-2.0	-0.7
Ambulatory time before self-admin	0.1	0.1	0.3	-0.1	0.0	-0.1	0.1	-0.5	-0.6
Ambulatory time after self-admin	0.7	0.7	2.7	-1.0	1.6	-0.0	-0.4	0.5	-0.6
Bone: tissue strength	0.1	0.1	0.4	0.3	-0.1	-0.6	0.0	0.2	-0.5
Total heroin consumption	0.3	0.3	0.7	0.8	-0.5	-0.4	-0.7	0.0	0.4
Bone: trabecular number	0.7	1.2	2.8	-0.6	1.7	0.2	-1.4	1.2	0.4
Bone: trabecular spacing	1.4	1.8	6.4	1.8	-2.5	-0.9	0.3	-0.2	0.5
Bone: trabecular thickness	1.6	2.0	3.4	-1.8	1.6	1.6	1.0	-1.2	-0.9
Bone: trabecular tissue density	2.6	3.6	7.9	0.5	-1.8	1.9	2.8	-2.6	-0.4
Water consumed over 24 hours	0.1	0.2	0.4	-0.6	0.7	-0.3	0.2	-0.0	-0.3
Number of responses in last shaping day	0.6	0.6	3.3	0.1	-0.4	0.2	0.2	0.0	-1.8