Hub : Genes

Edem1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr4_143375151_143377142 0.14 0.08 8.4e-11 0.1 0.09 0.09 0.1 2.3e-11 2.3e-10 1.9e-10 4.6e-11
2 Adipose intron excision ratio chr4_143377215_143378674 0.15 0.09 2.7e-11 0.11 0.1 0.1 0.1 8.5e-12 3.7e-11 1.3e-11 1.2e-11
3 Brain gene expression Edem1 0.06 0.04 1.5e-05 0.03 0.04 0.02 0.03 9.7e-04 2.0e-04 5.3e-03 4.4e-04
4 Brain intron excision ratio chr4_143377215_143378674 0.05 0.04 3.7e-03 0.02 0.02 0.02 0.02 3.6e-03 2.3e-03 1.1e-02 9.7e-03
5 NAcc intron excision ratio chr4_143377215_143378674 0.01 0.01 5.9e-03 0 0.01 0.01 0.01 8.5e-02 1.1e-02 1.2e-02 2.0e-02
6 Liver mRNA stability Edem1 0.05 0.03 3.0e-04 0.03 0.04 0.03 0.03 2.1e-04 8.3e-05 2.6e-04 1.8e-04
7 Liver gene expression Edem1 0.03 0.02 3.7e-03 -0 0.01 0 0 4.8e-01 1.9e-02 7.2e-02 2.1e-01
8 Adipose gene expression Edem1 0.03 0.02 1.1e-03 0.03 0.02 0.02 0.02 1.8e-04 3.1e-03 2.1e-03 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.42.51.4-1.4-1.11.2-0.41.6-1.20.2
Area under the delay curve0.81.22.50.8-0.8-1.41.01.60.20.6-1.5
BMI with tail0.82.75.71.2-1.2-2.32.02.40.30.8-1.7
BMI without tail0.10.31.00.1-0.1-0.70.61.0-0.20.5-0.4
Body weight0.41.73.31.0-1.0-1.81.31.70.60.5-1.7
Weight adjusted by age0.20.60.9-0.90.90.4-0.70.6-0.81.0-0.7
Bone surface1.53.05.62.1-2.1-2.42.11.01.8-0.7-1.0
Bone volume1.73.45.42.3-2.3-2.22.20.12.3-1.5-0.1
Breakpoint value in progressive ratio session1.01.82.61.6-1.6-0.91.3-0.81.5-1.60.9
Number of licking bursts0.20.51.70.2-0.20.5-0.3-1.30.6-1.01.0
Context. condit. distance diff. score0.70.81.5-1.01.01.2-1.1-0.7-0.80.20.6
Locomotion velocity, session 10.30.30.7-0.40.40.8-0.5-0.7-0.3-0.30.8
Locomotion distance, session 10.60.81.5-0.70.71.2-0.8-1.1-0.4-0.41.2
Locomotion velocity, session 20.91.12.80.5-0.50.30.3-1.60.9-1.51.7
Locomotion distance, session 20.20.30.80.2-0.20.20.3-0.70.3-0.70.9
Locomotion velocity, session 30.10.10.20.1-0.1-0.30.10.40.00.2-0.5
Locomotion distance, session 30.91.02.21.1-1.1-1.51.31.00.8-0.1-0.8
Stereotopy head waving bouts, day 30.10.10.30.4-0.4-0.30.4-0.10.5-0.4-0.0
Stereotopy head waving duration, day 30.81.01.61.2-1.2-1.01.2-0.21.2-1.00.3
Locomotion velocity, session 70.10.10.60.1-0.10.10.3-0.4-0.0-0.40.8
Locomotion distance, session 70.00.10.1-0.00.0-0.10.30.4-0.30.20.1
Stereotopy head waving bouts, day 70.20.20.60.2-0.20.2-0.0-0.80.5-0.70.5
Stereotopy head waving duration, day 70.20.30.60.5-0.5-0.30.3-0.50.8-0.70.2
Locomotion velocity, session 81.21.42.5-1.51.51.6-1.2-0.5-1.40.60.8
Locomotion distance, session 80.40.72.0-0.10.10.7-0.2-1.30.2-0.91.4
Degree of sensitization distance1.71.93.3-1.71.71.6-1.4-0.1-1.81.00.4
Degree of sensitization stereotypy0.40.51.4-0.30.30.8-0.6-1.20.1-0.60.9
Conditioned locomotion1.61.83.61.3-1.3-0.50.9-1.41.8-1.91.2
Cocaine response after cond. corrected1.01.42.7-1.11.10.5-1.01.2-1.51.6-1.4
Cocaine response after cond. not corrected0.30.51.1-0.30.3-0.2-0.11.0-0.71.0-1.1
Cocaine response before conditioning2.93.56.02.3-2.3-2.02.5-0.12.0-1.70.6
Saline control response0.00.00.1-0.20.20.4-0.3-0.3-0.1-0.10.1
Bone: connectivity density0.10.10.20.4-0.4-0.50.40.10.4-0.2-0.2
Bone: cortical apparent density0.91.44.2-0.00.0-0.90.32.0-0.61.4-2.1
Bone: cortical area2.74.38.82.3-2.3-3.02.51.81.7-0.2-1.7
Bone: cortical porosity0.90.92.70.0-0.00.7-0.3-1.60.6-1.21.6
Bone: cortical porosity0.80.92.5-0.10.10.8-0.3-1.60.4-1.11.6
Bone: cortical thickness2.23.66.82.2-2.2-2.62.41.21.8-0.7-1.0
Bone: cortical thickness1.21.52.51.5-1.5-1.51.60.31.3-0.8-0.1
Bone: cortical tissue density1.01.64.5-0.30.3-0.70.02.0-0.81.6-2.1
Condit. Reinf. active minus inactive responses0.00.00.1-0.20.20.1-0.20.2-0.20.2-0.3
Condit. Reinf. active-inactive response ratio0.50.50.9-0.80.80.7-0.90.2-0.80.7-0.5
Condit. Reinf. active responses0.10.10.30.1-0.10.2-0.0-0.50.3-0.40.5
Condit. Reinf. inactive responses0.30.31.20.1-0.10.30.1-0.80.3-0.71.1
Incentive salience index mean0.70.91.81.1-1.1-0.80.9-0.51.3-1.10.4
Condit. Reinf. lever presses2.63.86.32.2-2.2-1.41.9-1.22.5-2.41.3
Condit. Reinf. active minus inactive responses0.91.42.21.4-1.4-1.41.40.11.5-0.9-0.1
Condit. Reinf. active-inactive response ratio1.52.43.71.8-1.8-1.61.9-0.41.9-1.60.7
Condit. Reinf. active responses1.52.24.41.8-1.8-1.51.5-0.32.1-1.40.1
Condit. Reinf. inactive responses0.40.61.40.6-0.6-0.10.0-1.11.2-1.10.4
Condit. Reinf. lever presses1.92.84.42.0-2.0-1.92.00.02.1-1.40.2
Condit. Reinf. lever reinforcers received1.21.73.41.6-1.6-1.41.3-0.21.8-1.2-0.0
Conditioned reinforcement - actives0.00.10.1-0.30.30.2-0.00.0-0.40.10.3
Conditioned reinforcement - inactives0.30.91.7-0.90.90.0-0.61.2-0.81.3-1.2
Conditioned locomotion0.20.31.2-0.30.30.6-0.2-0.7-0.2-0.41.1
Patch foraging indifference point 0 sec0.10.20.40.3-0.3-0.20.5-0.20.3-0.40.6
Patch foraging indifference point AUC0.00.10.20.2-0.2-0.30.3-0.10.4-0.30.1
Delay disc. indifference point, 0s delay0.50.61.10.7-0.7-1.11.00.90.20.2-0.6
Delay disc. indifference point, 16s delay0.40.61.40.5-0.5-1.00.61.10.20.5-1.2
Delay disc. indifference point, 2s delay0.70.81.50.9-0.9-1.21.01.00.50.1-0.8
Delay disc. indifference point, 24s delay0.30.41.1-0.40.4-0.1-0.20.9-0.50.9-1.0
Delay disc. indifference point, 4s delay0.40.51.1-0.40.4-0.2-0.01.1-0.81.0-0.7
Delay disc. indifference point, 8s delay1.01.63.11.2-1.2-1.81.31.50.70.3-1.6
Indifference point function ln k0.10.20.90.0-0.00.50.0-0.7-0.2-0.40.9
Indifference point function log k0.10.20.90.0-0.00.50.0-0.7-0.2-0.40.9
Patch foraging total patch changes 0 sec0.10.10.50.2-0.2-0.10.3-0.40.3-0.50.7
Patch foraging total patch changes 12 sec0.10.10.4-0.20.2-0.20.10.6-0.20.5-0.3
Patch foraging total patch changes 18 sec0.10.40.80.3-0.30.1-0.0-0.90.8-0.80.8
Patch foraging total patch changes 24 sec0.10.20.4-0.50.5-0.0-0.10.6-0.50.7-0.2
Patch foraging total patch changes 6 sec0.10.10.30.2-0.2-0.10.2-0.50.5-0.60.5
Patch foraging time to switch 0 sec0.20.61.0-1.01.01.0-1.0-0.4-0.80.40.1
Patch foraging water rate 0 sec0.31.02.00.9-0.9-0.10.7-1.21.0-1.41.3
Patch foraging water rate 12 sec0.10.20.50.5-0.5-0.20.4-0.50.5-0.70.4
Patch foraging water rate 18 sec0.10.30.70.7-0.7-0.60.80.10.4-0.4-0.0
Patch foraging water rate 24 sec0.40.51.10.6-0.60.00.5-0.90.5-1.01.1
Patch foraging water rate 6 sec0.00.00.00.2-0.20.00.0-0.20.1-0.2-0.1
Seeking ratio, delayed vs. immediate footshock2.13.04.8-2.22.21.3-1.81.0-2.02.0-0.8
Distance traveled before self-admin0.40.81.3-1.11.10.6-0.80.6-1.21.1-0.4
Distance traveled after self-admin0.71.22.4-1.31.30.7-0.80.8-1.51.4-0.5
Extensor digitorum longus weight1.24.97.7-2.62.61.9-2.31.0-2.82.5-1.2
Bone: elastic displacement2.53.25.9-1.71.70.8-1.41.7-2.22.4-1.8
Bone: elastic work1.11.43.6-0.40.4-0.5-0.01.9-1.01.7-1.8
Bone: endosteal estimation0.30.81.60.8-0.8-1.30.91.10.50.2-1.2
Bone: endosteal perimeter0.71.64.9-0.60.6-0.3-0.51.8-0.91.7-2.2
Epididymis fat weight1.99.528.10.7-0.7-3.32.15.3-1.03.2-4.5
Delta time in closed arm before/after self-admin0.30.30.50.7-0.7-0.50.4-0.10.7-0.5-0.1
Delta time in open arm before/after self-admin1.11.34.00.0-0.0-1.10.52.0-0.51.4-1.7
Diff in mean of infusions in LGA sessions1.93.47.21.7-1.7-0.11.0-2.31.9-2.71.9
Delay discount exponential model param0.81.12.5-0.60.61.3-0.9-1.6-0.1-0.81.5
Extinction: sum of active levers before priming0.30.41.00.8-0.8-0.40.3-0.51.0-0.8-0.1
Active lever presses in extinction session 60.20.30.6-0.50.50.7-0.5-0.6-0.4-0.10.5
Bone: final force2.64.28.12.4-2.4-2.82.61.32.0-0.7-1.2
Bone: final moment2.94.79.12.5-2.5-3.02.71.52.0-0.6-1.3
Food consumed during 24 hour testing period0.91.83.61.1-1.1-1.91.51.80.50.5-1.6
Glucose2.53.96.72.0-2.0-1.11.7-1.62.6-2.61.7
Heart weight1.32.14.11.7-1.7-2.02.01.21.0-0.2-0.7
Delay discount hyperbolic model param0.81.02.2-0.70.71.3-0.9-1.5-0.1-0.71.4
Intermittent access intake day 1-15 change0.10.40.7-0.80.80.5-0.80.2-0.60.6-0.7
Intermittent access intake escalation0.10.40.7-0.80.80.6-0.8-0.0-0.50.5-0.5
Intermittent access intake escalation 20.30.50.9-0.90.90.7-0.9-0.0-0.60.5-0.3
Intermitt. access day 1 inactive lever presses0.11.64.90.3-0.3-1.40.72.2-0.21.4-1.8
Intermitt. access day 15 inactive lever presses0.10.61.1-1.01.00.9-1.1-0.1-0.70.50.1
Intermitt. access escalation Index1.03.25.42.0-2.0-0.71.7-1.61.7-2.31.8
Intermittent access day 1 total infusions0.30.81.4-1.21.20.8-1.20.1-0.80.7-0.4
Intermittent access day 15 total infusions0.30.81.5-1.21.20.8-1.20.1-0.90.8-0.5
Intermittent access terminal intake (last 3 days)0.50.81.5-1.21.20.9-1.10.0-0.90.7-0.4
Intermittent access total infusions0.91.01.9-1.41.41.0-1.3-0.0-1.00.8-0.4
Intermittent access day 1 locomotion0.81.52.9-1.11.10.1-0.81.5-1.11.7-1.5
Intermittent access day 15 total locomotion0.10.30.5-0.70.70.6-0.7-0.1-0.50.4-0.0
Intermittent access total locomotion1.31.52.9-1.21.20.2-0.91.4-1.21.7-1.4
Intermittent access standard deviation0.31.52.3-1.51.50.6-1.11.0-1.31.5-1.0
Left kidney weight0.10.72.00.6-0.6-1.20.61.10.50.4-1.4
Right kidney weight0.21.63.31.1-1.1-1.71.01.40.90.3-1.8
Cocaine induced anxiety0.10.30.90.2-0.20.30.2-0.80.2-0.70.9
Post-drug Anxiety0.70.82.3-0.20.21.0-0.4-1.4-0.0-0.81.5
Baseline Anxiety0.60.91.6-1.21.21.3-1.2-0.5-0.90.40.5
Tail length0.10.82.1-0.90.91.2-1.4-0.9-0.3-0.00.0
Length with tail0.00.10.2-0.20.20.3-0.5-0.40.1-0.1-0.3
Length without tail1.05.19.32.7-2.7-3.02.81.42.1-0.7-1.6
Times rat made contact with spout0.50.61.30.9-0.9-1.11.20.70.5-0.1-0.4
Lifetime Intake1.72.13.7-1.91.91.3-1.70.3-1.51.4-0.7
Liver weight, left0.30.61.30.8-0.8-1.11.00.70.6-0.1-0.5
Liver weight, right0.91.63.31.4-1.4-1.81.81.10.9-0.2-0.5
Locomotor activity0.40.61.0-1.01.00.6-0.70.4-1.00.9-0.4
Locomotor testing distance0.10.30.5-0.50.50.7-0.6-0.6-0.3-0.10.6
Locomotor testing rearing0.20.61.1-0.90.90.5-0.60.6-1.01.0-0.4
Locomotion in novel chamber0.10.20.4-0.50.50.6-0.5-0.5-0.40.00.4
Locomotion in novel chamber post-restriction0.00.10.3-0.30.30.4-0.6-0.40.1-0.1-0.0
Fecal boli incidents, locomotor time 10.20.41.2-0.10.10.7-0.4-1.10.2-0.71.0
Change in fecal boli incidents, locomotor task0.60.61.2-1.01.00.9-0.7-0.0-1.10.60.3
Time >=10cm from walls, locomotor time 11.31.62.6-1.51.50.9-1.60.7-1.21.5-1.1
Bouts of movement, locomotor time 11.41.83.11.4-1.4-0.51.3-1.21.3-1.81.5
Total resting periods, locomotor time 11.51.83.31.2-1.2-0.31.1-1.41.2-1.81.8
Rest time, locomotor task time 12.33.79.01.2-1.20.40.7-2.71.5-2.73.0
Distance moved, locomotor task time 10.72.03.6-1.41.40.4-1.21.4-1.41.9-1.7
Vertical activity count, locomotor time 10.53.75.3-2.22.21.2-2.01.2-2.02.3-1.8
Time >=10cm from walls, locomotor time 21.85.28.4-2.92.92.0-2.50.8-2.72.4-0.8
Bouts of movement, locomotor time 20.10.30.5-0.40.40.0-0.20.7-0.60.7-0.7
Total resting periods, locomotor time 20.00.10.40.2-0.2-0.50.30.50.00.2-0.6
Rest time, locomotor task time 22.03.45.82.4-2.4-1.82.0-0.42.2-1.80.3
Distance moved, locomotor task time 22.93.96.7-2.62.62.1-2.30.1-2.31.70.1
Vertical activity count, locomotor time 21.73.97.0-2.42.42.6-2.3-1.3-1.80.61.3
Light reinforcement 10.83.76.6-2.42.42.5-2.6-1.1-1.60.70.8
Light reinforcement 20.10.20.4-0.50.50.6-0.5-0.6-0.2-0.10.6
Bone: marrow area0.40.91.80.8-0.8-1.30.91.20.50.3-1.3
Bone: maximum diameter0.91.73.41.1-1.1-1.81.21.60.70.4-1.8
Bone: maximum force1.12.14.01.7-1.7-2.01.90.91.4-0.5-0.7
Bone: maximum moment1.42.65.11.8-1.8-2.32.11.11.4-0.5-0.9
Mean time between licks in bursts0.21.12.30.8-0.8-0.00.4-1.41.3-1.51.2
Mean num. licks in bursts0.51.53.40.8-0.8-1.71.41.80.10.7-1.3
Cd content in liver0.80.81.6-1.11.11.2-1.3-0.6-0.80.30.3
Co content in liver0.91.11.9-1.21.21.4-1.1-0.6-1.10.40.9
Cu content in liver0.80.92.0-0.70.71.3-0.9-1.4-0.2-0.61.3
Fe content in liver0.30.30.70.7-0.7-0.60.80.00.6-0.50.3
K content in liver0.50.51.1-0.50.50.0-0.40.8-0.61.0-1.0
Mg content in liver0.20.20.4-0.60.60.5-0.5-0.1-0.60.30.1
Mn content in liver0.00.00.10.2-0.2-0.10.3-0.10.1-0.20.3
Na content in liver0.10.10.5-0.00.00.3-0.1-0.50.1-0.40.7
Rb content in liver0.91.02.1-0.90.90.3-0.91.0-1.01.3-1.4
Se content in liver0.10.10.2-0.20.20.4-0.3-0.4-0.0-0.20.3
Sr content in liver0.70.61.3-0.90.91.1-0.9-0.7-0.60.10.7
Zn content in liver2.52.94.3-2.02.01.4-1.90.8-2.11.9-1.1
Bone: minimum diameter1.52.85.61.7-1.7-2.41.71.81.20.2-2.0
Time in familiar zone, hab. session 10.10.10.30.0-0.0-0.30.30.6-0.20.4-0.3
Time in novel zone, hab. session 11.21.32.6-1.41.41.4-1.6-0.4-1.10.70.1
Total zone transitions, hab. session 10.40.61.1-0.80.81.1-1.0-0.9-0.4-0.10.7
Total locomotion distance, hab. session 10.20.20.6-0.30.30.6-0.5-0.80.0-0.40.6
Locomotion velocity, hab. session 10.20.30.70.3-0.30.10.0-0.80.6-0.80.7
Time in familiar zone, hab. session 20.10.10.3-0.20.20.0-0.00.4-0.50.5-0.2
Time in novel zone, hab. session 20.70.81.6-0.90.91.3-1.2-1.1-0.4-0.20.8
Total zone transitions, hab. session 21.01.32.1-1.41.41.4-1.5-0.3-1.30.80.1
Total locomotion distance, hab. session 20.50.71.3-1.01.01.1-1.2-0.5-0.70.30.2
Locomotion velocity, hab. session 20.10.20.5-0.50.50.6-0.7-0.2-0.30.2-0.1
Novel to familiar place preference ratio0.10.10.20.3-0.3-0.30.2-0.00.4-0.2-0.2
Novelty place preference0.30.40.60.7-0.7-0.70.6-0.00.8-0.5-0.0
Time in novel zone, NPP test0.40.40.80.8-0.8-0.70.7-0.10.9-0.60.1
Total zone transitions, NPP test0.40.50.90.8-0.8-0.50.7-0.50.9-0.90.5
Total locomotion distance, NPP test0.60.81.80.5-0.50.20.2-1.40.9-1.31.2
Locomotion velocity, NPP test0.50.71.40.7-0.7-0.10.4-1.11.0-1.20.9
Intraocular pressure1.01.64.2-0.60.6-0.50.22.1-1.41.8-1.6
Delta distance traveled before/after self-admin0.10.10.40.3-0.3-0.40.60.4-0.00.0-0.0
Delta ambulatory time before/after self-admin0.00.10.3-0.20.20.20.2-0.1-0.3-0.00.6
Parametrial fat weight0.30.62.1-0.30.3-0.50.31.4-0.81.1-0.7
Pavlov. Cond. lever latency2.73.56.5-1.71.70.7-1.51.8-2.22.5-2.1
Pavlov. Cond. magazine entry latency0.20.30.60.7-0.7-0.50.8-0.10.6-0.50.3
Pavlov. Cond. change in total contacts1.01.11.71.2-1.2-0.81.1-0.61.3-1.20.7
Pavlov. Cond. index score1.62.03.01.6-1.6-1.11.5-0.81.7-1.71.0
Pavlov. Cond. latency score1.82.23.41.6-1.6-1.01.5-1.01.8-1.81.2
Pavlov. Cond. lever contacts2.22.74.61.6-1.6-0.81.5-1.42.0-2.21.6
Pavlov. Cond. magazine entry number0.40.51.0-0.90.90.9-1.0-0.2-0.80.5-0.0
Pavlov. Cond. intertrial magazine entries0.60.71.8-0.40.40.9-0.5-1.30.1-0.71.3
Pavlov. Cond. lever-magazine prob. diff.1.62.03.11.6-1.6-1.11.5-0.81.8-1.70.9
Pavlov. Cond. response bias1.11.32.01.4-1.4-1.21.4-0.21.4-1.10.4
Pavlov. Cond. lever latency2.33.25.1-2.32.32.0-2.1-0.1-2.21.5-0.2
Pavlov. Cond. magazine entry latency0.91.22.51.2-1.2-1.61.31.20.70.1-0.9
Pavlov. Cond. change in total contacts1.02.54.12.0-2.0-2.01.90.51.8-0.9-0.3
Pavlov. Cond. index score1.62.54.02.0-2.0-2.02.00.51.8-0.9-0.2
Pavlov. Cond. latency score1.72.74.82.0-2.0-2.22.10.91.6-0.7-0.5
Pavlov. Cond. lever contacts2.63.86.02.4-2.4-2.12.3-0.02.4-1.70.2
Pavlov. Cond. magazine entry number1.01.32.7-1.11.11.6-1.3-1.4-0.6-0.31.1
Pavlov. Cond. intertrial magazine entries0.20.51.40.1-0.10.40.0-1.10.4-0.91.2
Pavlov. Cond. lever-magazine prob. diff.1.52.33.71.9-1.9-1.91.90.51.7-0.9-0.2
Pavlov. Cond. response bias1.92.64.22.0-2.0-1.81.90.11.9-1.30.2
Time in closed arm before self-admin0.71.32.71.2-1.2-1.61.61.20.50.1-0.7
Time in closed arm after self-admin0.50.61.10.7-0.7-0.20.6-0.80.7-1.01.0
Time in open arm before self-admin0.70.82.20.4-0.40.4-0.1-1.50.8-1.31.2
Time in open arm after self-admin0.70.81.50.9-0.9-1.21.20.90.40.1-0.7
Bone: periosteal estimation1.12.75.41.7-1.7-2.31.81.61.20.0-1.7
Bone: periosteal perimeter0.51.13.20.2-0.2-1.00.41.7-0.31.1-1.8
Bone: post-yield work0.50.91.41.2-1.2-1.11.20.11.1-0.8-0.0
Progressive ratio test 1 active lever presses0.61.11.6-1.21.20.5-1.00.8-1.01.2-1.1
Progressive ratio test 1 breakpoint0.71.11.7-1.31.30.5-1.00.7-1.11.3-1.0
Progressive ratio test 1 inactive lever presses0.71.83.3-1.51.50.5-1.01.3-1.51.8-1.1
Progressive ratio test 2 active lever presses0.60.91.6-1.21.20.7-0.90.4-1.11.0-0.4
Progressive ratio test 2 breakpoint0.81.12.0-1.41.40.9-1.00.3-1.21.0-0.3
Progressive ratio test 2 inactive lever presses0.61.93.6-1.91.91.5-1.4-0.1-1.61.00.4
Incentive Sensitization - Responses0.30.91.7-1.31.31.0-0.80.0-1.30.70.4
Incentive Sensitization - Breakpoint0.51.01.9-1.41.41.1-0.9-0.0-1.30.80.4
Sum of active levers in priming session hrs 5-60.50.51.60.1-0.1-0.70.21.1-0.10.7-1.2
Progressive ratio0.20.50.90.7-0.7-1.00.70.80.40.1-0.9
Food seeking constrained by brief footshock0.20.20.40.5-0.5-0.60.60.40.3-0.1-0.4
Seeking ratio, punishment vs. effort0.00.00.2-0.10.10.10.1-0.2-0.1-0.10.5
Retroperitoneal fat weight1.46.415.71.5-1.5-3.32.34.00.31.8-3.4
Reaction time number correct0.31.12.7-1.21.21.5-1.6-0.9-0.60.10.2
Reaction time mean minus median0.21.43.40.7-0.7-1.51.11.8-0.00.9-1.7
Reaction time mean minus median AUC0.10.92.7-0.00.0-0.80.41.6-0.61.2-1.5
Reaction time num false alarms1.11.85.8-0.10.11.2-0.4-2.10.3-1.42.4
Reaction time num false alarms AUC1.22.78.80.1-0.11.3-0.2-2.60.6-1.93.0
Reaction time trials correct on left0.31.12.7-1.21.21.5-1.6-0.9-0.60.10.2
Reaction time trials on left0.31.12.6-1.11.11.4-1.6-0.9-0.60.20.1
Reaction time mean0.71.53.70.8-0.8-1.61.31.90.00.8-1.5
Reaction time mean AUC0.51.33.30.7-0.7-1.51.21.8-0.10.8-1.3
Median of all reaction times0.50.82.10.6-0.6-1.21.01.4-0.10.7-1.0
Reaction time omissions0.40.71.90.3-0.3-0.90.71.4-0.30.8-1.2
Reaction time false alarm rate1.42.06.20.8-0.80.30.6-1.91.0-1.92.5
Reaction time premature initiation rate0.10.10.4-0.10.1-0.1-0.00.4-0.20.3-0.6
Reaction time premature initiations0.20.51.1-0.90.90.7-1.0-0.1-0.60.5-0.5
Std. dev. reaction times0.62.04.01.4-1.4-2.01.71.70.60.3-1.4
Reaction time trials completed0.31.12.6-1.11.11.4-1.6-0.9-0.60.20.1
Reaction time trials AUC0.31.02.6-1.11.11.4-1.6-0.9-0.50.10.1
Run reversals in cocaine runway, females1.41.62.91.7-1.7-1.41.70.21.1-0.90.0
Run reversals in cocaine runway, males0.20.20.5-0.40.4-0.0-0.20.7-0.50.7-0.6
Latency to leave start box in cocaine runway0.60.81.8-0.60.61.2-1.0-1.3-0.1-0.61.1
Latency to leave start box in cocaine runway, F0.50.61.2-0.90.91.0-1.1-0.7-0.40.00.5
Latency to leave start box in cocaine runway, M0.30.30.90.2-0.20.30.1-0.80.2-0.70.9
Std. dev. time between licks in bursts1.73.35.72.1-2.1-1.61.8-0.82.4-2.00.8
Total sessions with >9 infusions1.92.43.7-1.91.90.8-1.51.1-1.71.9-1.2
Short access day 1 total inactive lever presses0.81.72.7-1.61.60.8-1.20.9-1.51.6-0.5
Short access day 10 total inactive lever presses0.10.92.21.1-1.1-1.31.51.00.5-0.0-0.3
Short access day 1 total infusions1.83.56.3-2.52.51.5-2.10.6-1.91.9-1.1
Short access day 10 total infusions0.61.01.7-1.11.10.3-0.90.9-0.91.3-1.1
Short access total infusions2.33.35.3-2.32.31.2-1.91.0-1.92.0-1.4
Short access day 1 locomotion0.30.61.9-0.00.0-0.70.21.2-0.20.8-1.4
Short access day 10 total locomotion1.04.28.1-2.12.10.3-1.42.3-2.02.9-2.3
Short access total locomotion2.13.15.5-2.02.00.6-1.41.7-1.92.3-1.7
One hour access (0.3 mA shock)0.50.61.1-1.01.00.6-0.90.3-0.80.9-0.6
Compulsive drug intake0.10.10.20.3-0.3-0.40.10.40.20.2-0.4
One hour access (shock baseline)0.10.20.4-0.60.60.5-0.5-0.1-0.40.3-0.1
Social response proportion0.40.51.50.3-0.3-0.90.61.2-0.10.6-1.1
Social responses1.01.32.41.4-1.4-1.31.1-0.11.6-1.1-0.3
Social time1.52.44.61.4-1.4-2.11.71.90.70.5-1.9
Soleus weight0.00.10.2-0.10.10.2-0.4-0.20.1-0.0-0.3
Bone: stiffness0.71.22.11.3-1.3-1.31.40.01.3-0.90.2
Tibialis anterior weight1.65.57.4-2.62.61.8-2.71.2-2.62.7-2.1
Time to tail flick, vehicle, before self-admin2.43.05.2-2.32.31.6-1.90.5-2.01.8-0.2
Time to tail flick, vehicle, after self-admin0.10.10.60.1-0.10.10.3-0.2-0.2-0.20.8
Time to tail flick, test, before self-admin0.40.40.80.8-0.8-0.70.90.10.6-0.50.3
Time to tail flick, test, after self-admin1.61.72.91.4-1.4-0.51.2-1.11.3-1.71.3
Delta time to tail flick, vehicle, before/after SA0.10.10.20.4-0.4-0.30.50.00.2-0.20.0
Delta time to tail flick, test, before/after SA0.81.02.00.8-0.80.00.6-1.30.8-1.41.4
Tibia length2.67.319.41.3-1.3-3.21.74.20.12.2-4.4
Ambulatory time before self-admin0.41.12.2-1.01.00.3-0.81.1-1.21.5-1.1
Ambulatory time after self-admin0.91.42.6-1.31.30.5-0.71.2-1.61.6-0.8
Bone: tissue strength0.00.00.0-0.00.00.1-0.0-0.2-0.0-0.10.2
Total heroin consumption0.10.20.40.2-0.2-0.50.30.7-0.00.3-0.6
Bone: trabecular number0.51.02.01.1-1.1-1.41.20.90.8-0.1-0.8
Bone: trabecular spacing1.52.23.8-1.81.81.9-1.7-0.7-1.60.70.7
Bone: trabecular thickness3.75.17.82.7-2.7-2.32.6-0.52.8-2.30.7
Bone: trabecular tissue density0.00.10.20.3-0.3-0.40.40.10.2-0.1-0.0
Water consumed over 24 hours1.53.06.11.6-1.6-2.52.32.00.80.3-1.4
Number of responses in last shaping day0.20.30.6-0.80.80.7-0.6-0.2-0.60.20.3