Hub : Genes

Edem1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr4_143375151_143377142 0.14 0.08 8.4e-11 0.1 0.09 0.09 0.1 2.3e-11 2.3e-10 1.9e-10 4.5e-11
2 Adipose intron excision ratio chr4_143377215_143378674 0.15 0.09 2.7e-11 0.11 0.1 0.1 0.1 8.5e-12 3.7e-11 1.5e-11 1.3e-11
3 Brain gene expression Edem1 0.06 0.04 1.5e-05 0.03 0.04 0.02 0.03 9.7e-04 2.0e-04 5.2e-03 4.5e-04
4 Brain intron excision ratio chr4_143377215_143378674 0.05 0.04 3.7e-03 0.02 0.02 0.02 0.02 3.6e-03 2.3e-03 1.1e-02 9.4e-03
5 NAcc intron excision ratio chr4_143377215_143378674 0.01 0.01 5.9e-03 0 0.01 0.01 0.01 8.5e-02 1.1e-02 1.2e-02 1.9e-02
6 Liver mRNA stability Edem1 0.05 0.03 3.0e-04 0.03 0.04 0.03 0.03 2.1e-04 8.3e-05 2.6e-04 1.7e-04
7 Liver gene expression Edem1 0.03 0.02 3.7e-03 -0 0.01 0 0 4.8e-01 1.9e-02 7.2e-02 1.9e-01
8 Adipose gene expression Edem1 0.03 0.02 1.1e-03 0.03 0.02 0.02 0.02 1.8e-04 3.1e-03 2.1e-03 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.81.42.5-1.41.4-1.11.2-0.41.6-1.2-0.2
Area under the delay curve1.01.22.5-0.80.8-1.41.01.60.20.61.5
BMI with tail0.82.75.7-1.21.2-2.32.02.40.30.81.7
BMI without tail0.10.31.0-0.10.1-0.70.61.0-0.20.50.4
Body weight0.41.73.3-1.01.0-1.81.31.70.60.51.7
Weight adjusted by age0.40.60.90.9-0.90.4-0.70.6-0.81.00.7
Bone surface1.73.05.6-2.12.1-2.42.11.01.8-0.71.0
Bone volume1.93.45.4-2.32.3-2.22.20.12.3-1.50.1
Breakpoint value in progressive ratio session1.51.82.6-1.61.6-0.91.3-0.81.5-1.6-0.9
Number of licking bursts0.30.51.7-0.20.20.5-0.3-1.30.6-1.0-1.0
Context. condit. distance diff. score0.70.81.51.0-1.01.2-1.1-0.7-0.80.2-0.6
Locomotion velocity, session 10.30.30.70.4-0.40.8-0.5-0.7-0.3-0.3-0.8
Locomotion distance, session 10.60.81.50.7-0.71.2-0.8-1.1-0.4-0.4-1.2
Locomotion velocity, session 21.01.12.8-0.50.50.30.3-1.60.9-1.5-1.7
Locomotion distance, session 20.20.30.8-0.20.20.20.3-0.70.3-0.7-0.9
Locomotion velocity, session 30.10.10.2-0.10.1-0.30.10.40.00.20.5
Locomotion distance, session 30.91.02.2-1.11.1-1.51.31.00.8-0.10.8
Stereotopy head waving bouts, day 30.10.10.3-0.40.4-0.30.4-0.10.5-0.40.0
Stereotopy head waving duration, day 30.91.01.6-1.21.2-1.01.2-0.21.2-1.0-0.3
Locomotion velocity, session 70.10.10.6-0.10.10.10.3-0.4-0.0-0.4-0.8
Locomotion distance, session 70.00.10.10.0-0.0-0.10.30.4-0.30.2-0.1
Stereotopy head waving bouts, day 70.20.20.6-0.20.20.2-0.0-0.80.5-0.7-0.5
Stereotopy head waving duration, day 70.20.30.6-0.50.5-0.30.3-0.50.8-0.7-0.2
Locomotion velocity, session 81.21.42.51.5-1.51.6-1.2-0.5-1.40.6-0.8
Locomotion distance, session 80.40.72.00.1-0.10.7-0.2-1.30.2-0.9-1.4
Degree of sensitization distance1.81.93.31.7-1.71.6-1.4-0.1-1.81.0-0.4
Degree of sensitization stereotypy0.50.51.40.3-0.30.8-0.6-1.20.1-0.6-0.9
Conditioned locomotion1.61.83.6-1.31.3-0.50.9-1.41.8-1.9-1.2
Cocaine response after cond. corrected1.21.42.71.1-1.10.5-1.01.2-1.51.61.4
Cocaine response after cond. not corrected0.40.51.10.3-0.3-0.2-0.11.0-0.71.01.1
Cocaine response before conditioning2.93.56.0-2.32.3-2.02.5-0.12.0-1.7-0.6
Saline control response0.00.00.10.2-0.20.4-0.3-0.3-0.1-0.1-0.1
Bone: connectivity density0.10.10.2-0.40.4-0.50.40.10.4-0.20.2
Bone: cortical apparent density1.01.44.20.0-0.0-0.90.32.0-0.61.42.1
Bone: cortical area2.84.38.8-2.32.3-3.02.51.81.7-0.21.7
Bone: cortical porosity0.90.92.7-0.00.00.7-0.3-1.60.6-1.2-1.6
Bone: cortical porosity0.80.92.50.1-0.10.8-0.3-1.60.4-1.1-1.6
Bone: cortical thickness2.23.66.8-2.22.2-2.62.41.21.8-0.71.0
Bone: cortical thickness1.31.52.5-1.51.5-1.51.60.31.3-0.80.1
Bone: cortical tissue density1.11.64.50.3-0.3-0.70.02.0-0.81.62.1
Condit. Reinf. active minus inactive responses0.00.00.10.2-0.20.1-0.20.2-0.20.20.3
Condit. Reinf. active-inactive response ratio0.50.50.90.8-0.80.7-0.90.2-0.80.70.5
Condit. Reinf. active responses0.10.10.3-0.10.10.2-0.0-0.50.3-0.4-0.5
Condit. Reinf. inactive responses0.30.31.2-0.10.10.30.1-0.80.3-0.7-1.1
Incentive salience index mean0.70.91.8-1.11.1-0.80.9-0.51.3-1.1-0.4
Condit. Reinf. lever presses2.73.86.3-2.22.2-1.41.9-1.22.5-2.4-1.3
Condit. Reinf. active minus inactive responses1.11.42.2-1.41.4-1.41.40.11.5-0.90.1
Condit. Reinf. active-inactive response ratio2.12.43.7-1.81.8-1.61.9-0.41.9-1.6-0.7
Condit. Reinf. active responses1.62.24.4-1.81.8-1.51.5-0.32.1-1.4-0.1
Condit. Reinf. inactive responses0.50.61.4-0.60.6-0.10.0-1.11.2-1.1-0.4
Condit. Reinf. lever presses2.02.84.4-2.02.0-1.92.00.02.1-1.4-0.2
Condit. Reinf. lever reinforcers received1.21.73.4-1.61.6-1.41.3-0.21.8-1.20.0
Conditioned reinforcement - actives0.00.10.10.3-0.30.2-0.00.0-0.40.1-0.3
Conditioned reinforcement - inactives0.60.91.70.9-0.90.0-0.61.2-0.81.31.2
Conditioned locomotion0.20.31.20.3-0.30.6-0.2-0.7-0.2-0.4-1.1
Patch foraging indifference point 0 sec0.10.20.4-0.30.3-0.20.5-0.20.3-0.4-0.6
Patch foraging indifference point AUC0.00.10.2-0.20.2-0.30.3-0.10.4-0.3-0.1
Delay disc. indifference point, 0s delay0.50.61.1-0.70.7-1.11.00.90.20.20.6
Delay disc. indifference point, 16s delay0.50.61.4-0.50.5-1.00.61.10.20.51.2
Delay disc. indifference point, 2s delay0.70.81.5-0.90.9-1.21.01.00.50.10.8
Delay disc. indifference point, 24s delay0.40.41.10.4-0.4-0.1-0.20.9-0.50.91.0
Delay disc. indifference point, 4s delay0.40.51.10.4-0.4-0.2-0.01.1-0.81.00.7
Delay disc. indifference point, 8s delay1.41.63.1-1.21.2-1.81.31.50.70.31.6
Indifference point function ln k0.10.20.9-0.00.00.50.0-0.7-0.2-0.4-0.9
Indifference point function log k0.10.20.9-0.00.00.50.0-0.7-0.2-0.4-0.9
Patch foraging total patch changes 0 sec0.10.10.5-0.20.2-0.10.3-0.40.3-0.5-0.7
Patch foraging total patch changes 12 sec0.10.10.40.2-0.2-0.20.10.6-0.20.50.3
Patch foraging total patch changes 18 sec0.20.40.8-0.30.30.1-0.0-0.90.8-0.8-0.8
Patch foraging total patch changes 24 sec0.10.20.40.5-0.5-0.0-0.10.6-0.50.70.2
Patch foraging total patch changes 6 sec0.10.10.3-0.20.2-0.10.2-0.50.5-0.6-0.5
Patch foraging time to switch 0 sec0.30.61.01.0-1.01.0-1.0-0.4-0.80.4-0.1
Patch foraging water rate 0 sec0.51.02.0-0.90.9-0.10.7-1.21.0-1.4-1.3
Patch foraging water rate 12 sec0.10.20.5-0.50.5-0.20.4-0.50.5-0.7-0.4
Patch foraging water rate 18 sec0.20.30.7-0.70.7-0.60.80.10.4-0.40.0
Patch foraging water rate 24 sec0.40.51.1-0.60.60.00.5-0.90.5-1.0-1.1
Patch foraging water rate 6 sec0.00.00.0-0.20.20.00.0-0.20.1-0.20.1
Seeking ratio, delayed vs. immediate footshock2.53.04.82.2-2.21.3-1.81.0-2.02.00.8
Distance traveled before self-admin0.60.81.31.1-1.10.6-0.80.6-1.21.10.4
Distance traveled after self-admin1.01.22.41.3-1.30.7-0.80.8-1.51.40.5
Extensor digitorum longus weight1.24.97.72.6-2.61.9-2.31.0-2.82.51.2
Bone: elastic displacement2.73.25.91.7-1.70.8-1.41.7-2.22.41.8
Bone: elastic work1.11.43.60.4-0.4-0.5-0.01.9-1.01.71.8
Bone: endosteal estimation0.40.81.6-0.80.8-1.30.91.10.50.21.2
Bone: endosteal perimeter0.71.64.90.6-0.6-0.3-0.51.8-0.91.72.2
Epididymis fat weight2.89.528.1-0.70.7-3.32.15.3-1.03.24.5
Delta time in closed arm before/after self-admin0.30.30.5-0.70.7-0.50.4-0.10.7-0.50.1
Delta time in open arm before/after self-admin1.31.34.0-0.00.0-1.10.52.0-0.51.41.7
Diff in mean of infusions in LGA sessions2.83.47.2-1.71.7-0.11.0-2.31.9-2.7-1.9
Delay discount exponential model param1.01.12.50.6-0.61.3-0.9-1.6-0.1-0.8-1.5
Extinction: sum of active levers before priming0.40.41.0-0.80.8-0.40.3-0.51.0-0.80.1
Active lever presses in extinction session 60.30.30.60.5-0.50.7-0.5-0.6-0.4-0.1-0.5
Bone: final force2.64.28.1-2.42.4-2.82.61.32.0-0.71.2
Bone: final moment2.94.79.1-2.52.5-3.02.71.52.0-0.61.3
Food consumed during 24 hour testing period1.31.83.6-1.11.1-1.91.51.80.50.51.6
Glucose2.53.96.7-2.02.0-1.11.7-1.62.6-2.6-1.7
Heart weight1.42.14.1-1.71.7-2.02.01.21.0-0.20.7
Delay discount hyperbolic model param0.91.02.20.7-0.71.3-0.9-1.5-0.1-0.7-1.4
Intermittent access intake day 1-15 change0.20.40.70.8-0.80.5-0.80.2-0.60.60.7
Intermittent access intake escalation0.20.40.70.8-0.80.6-0.8-0.0-0.50.50.5
Intermittent access intake escalation 20.40.50.90.9-0.90.7-0.9-0.0-0.60.50.3
Intermitt. access day 1 inactive lever presses0.41.64.9-0.30.3-1.40.72.2-0.21.41.8
Intermitt. access day 15 inactive lever presses0.30.61.11.0-1.00.9-1.1-0.1-0.70.5-0.1
Intermitt. access escalation Index2.23.25.4-2.02.0-0.71.7-1.61.7-2.3-1.8
Intermittent access day 1 total infusions0.50.81.41.2-1.20.8-1.20.1-0.80.70.4
Intermittent access day 15 total infusions0.60.81.51.2-1.20.8-1.20.1-0.90.80.5
Intermittent access terminal intake (last 3 days)0.60.81.51.2-1.20.9-1.10.0-0.90.70.4
Intermittent access total infusions0.91.01.91.4-1.41.0-1.3-0.0-1.00.80.4
Intermittent access day 1 locomotion1.21.52.91.1-1.10.1-0.81.5-1.11.71.5
Intermittent access day 15 total locomotion0.20.30.50.7-0.70.6-0.7-0.1-0.50.40.0
Intermittent access total locomotion1.31.52.91.2-1.20.2-0.91.4-1.21.71.4
Intermittent access standard deviation0.71.52.31.5-1.50.6-1.11.0-1.31.51.0
Left kidney weight0.20.72.0-0.60.6-1.20.61.10.50.41.4
Right kidney weight0.31.63.3-1.11.1-1.71.01.40.90.31.8
Cocaine induced anxiety0.20.30.9-0.20.20.30.2-0.80.2-0.7-0.9
Post-drug Anxiety0.70.82.30.2-0.21.0-0.4-1.4-0.0-0.8-1.5
Baseline Anxiety0.80.91.61.2-1.21.3-1.2-0.5-0.90.4-0.5
Tail length0.20.82.10.9-0.91.2-1.4-0.9-0.3-0.0-0.0
Length with tail0.00.10.20.2-0.20.3-0.5-0.40.1-0.10.3
Length without tail1.65.19.3-2.72.7-3.02.81.42.1-0.71.6
Times rat made contact with spout0.50.61.3-0.90.9-1.11.20.70.5-0.10.4
Lifetime Intake1.72.13.71.9-1.91.3-1.70.3-1.51.40.7
Liver weight, left0.40.61.3-0.80.8-1.11.00.70.6-0.10.5
Liver weight, right0.91.63.3-1.41.4-1.81.81.10.9-0.20.5
Locomotor activity0.40.61.01.0-1.00.6-0.70.4-1.00.90.4
Locomotor testing distance0.20.30.50.5-0.50.7-0.6-0.6-0.3-0.1-0.6
Locomotor testing rearing0.30.61.10.9-0.90.5-0.60.6-1.01.00.4
Locomotion in novel chamber0.20.20.40.5-0.50.6-0.5-0.5-0.40.0-0.4
Locomotion in novel chamber post-restriction0.10.10.30.3-0.30.4-0.6-0.40.1-0.10.0
Fecal boli incidents, locomotor time 10.30.41.20.1-0.10.7-0.4-1.10.2-0.7-1.0
Change in fecal boli incidents, locomotor task0.60.61.21.0-1.00.9-0.7-0.0-1.10.6-0.3
Time >=10cm from walls, locomotor time 11.51.62.61.5-1.50.9-1.60.7-1.21.51.1
Bouts of movement, locomotor time 11.51.83.1-1.41.4-0.51.3-1.21.3-1.8-1.5
Total resting periods, locomotor time 11.61.83.3-1.21.2-0.31.1-1.41.2-1.8-1.8
Rest time, locomotor task time 13.03.79.0-1.21.20.40.7-2.71.5-2.7-3.0
Distance moved, locomotor task time 11.42.03.61.4-1.40.4-1.21.4-1.41.91.7
Vertical activity count, locomotor time 11.53.75.32.2-2.21.2-2.01.2-2.02.31.8
Time >=10cm from walls, locomotor time 23.55.28.42.9-2.92.0-2.50.8-2.72.40.8
Bouts of movement, locomotor time 20.20.30.50.4-0.40.0-0.20.7-0.60.70.7
Total resting periods, locomotor time 20.10.10.4-0.20.2-0.50.30.50.00.20.6
Rest time, locomotor task time 22.73.45.8-2.42.4-1.82.0-0.42.2-1.8-0.3
Distance moved, locomotor task time 23.23.96.72.6-2.62.1-2.30.1-2.31.7-0.1
Vertical activity count, locomotor time 22.83.97.02.4-2.42.6-2.3-1.3-1.80.6-1.3
Light reinforcement 11.53.76.62.4-2.42.5-2.6-1.1-1.60.7-0.8
Light reinforcement 20.20.20.40.5-0.50.6-0.5-0.6-0.2-0.1-0.6
Bone: marrow area0.40.91.8-0.80.8-1.30.91.20.50.31.3
Bone: maximum diameter0.91.73.4-1.11.1-1.81.21.60.70.41.8
Bone: maximum force1.22.14.0-1.71.7-2.01.90.91.4-0.50.7
Bone: maximum moment1.52.65.1-1.81.8-2.32.11.11.4-0.50.9
Mean time between licks in bursts0.41.12.3-0.80.8-0.00.4-1.41.3-1.5-1.2
Mean num. licks in bursts0.91.53.4-0.80.8-1.71.41.80.10.71.3
Cd content in liver0.80.81.61.1-1.11.2-1.3-0.6-0.80.3-0.3
Co content in liver0.91.11.91.2-1.21.4-1.1-0.6-1.10.4-0.9
Cu content in liver0.80.92.00.7-0.71.3-0.9-1.4-0.2-0.6-1.3
Fe content in liver0.30.30.7-0.70.7-0.60.80.00.6-0.5-0.3
K content in liver0.50.51.10.5-0.50.0-0.40.8-0.61.01.0
Mg content in liver0.20.20.40.6-0.60.5-0.5-0.1-0.60.3-0.1
Mn content in liver0.00.00.1-0.20.2-0.10.3-0.10.1-0.2-0.3
Na content in liver0.10.10.50.0-0.00.3-0.1-0.50.1-0.4-0.7
Rb content in liver0.91.02.10.9-0.90.3-0.91.0-1.01.31.4
Se content in liver0.10.10.20.2-0.20.4-0.3-0.4-0.0-0.2-0.3
Sr content in liver0.70.61.30.9-0.91.1-0.9-0.7-0.60.1-0.7
Zn content in liver2.62.94.32.0-2.01.4-1.90.8-2.11.91.1
Bone: minimum diameter1.52.85.6-1.71.7-2.41.71.81.20.22.0
Time in familiar zone, hab. session 10.10.10.3-0.00.0-0.30.30.6-0.20.40.3
Time in novel zone, hab. session 11.31.32.61.4-1.41.4-1.6-0.4-1.10.7-0.1
Total zone transitions, hab. session 10.40.61.10.8-0.81.1-1.0-0.9-0.4-0.1-0.7
Total locomotion distance, hab. session 10.20.20.60.3-0.30.6-0.5-0.80.0-0.4-0.6
Locomotion velocity, hab. session 10.20.30.7-0.30.30.10.0-0.80.6-0.8-0.7
Time in familiar zone, hab. session 20.10.10.30.2-0.20.0-0.00.4-0.50.50.2
Time in novel zone, hab. session 20.80.81.60.9-0.91.3-1.2-1.1-0.4-0.2-0.8
Total zone transitions, hab. session 21.01.32.11.4-1.41.4-1.5-0.3-1.30.8-0.1
Total locomotion distance, hab. session 20.50.71.31.0-1.01.1-1.2-0.5-0.70.3-0.2
Locomotion velocity, hab. session 20.10.20.50.5-0.50.6-0.7-0.2-0.30.20.1
Novel to familiar place preference ratio0.10.10.2-0.30.3-0.30.2-0.00.4-0.20.2
Novelty place preference0.30.40.6-0.70.7-0.70.6-0.00.8-0.50.0
Time in novel zone, NPP test0.40.40.8-0.80.8-0.70.7-0.10.9-0.6-0.1
Total zone transitions, NPP test0.40.50.9-0.80.8-0.50.7-0.50.9-0.9-0.5
Total locomotion distance, NPP test0.60.81.8-0.50.50.20.2-1.40.9-1.3-1.2
Locomotion velocity, NPP test0.50.71.4-0.70.7-0.10.4-1.11.0-1.2-0.9
Intraocular pressure1.11.64.20.6-0.6-0.50.22.1-1.41.81.6
Delta distance traveled before/after self-admin0.10.10.4-0.30.3-0.40.60.4-0.00.00.0
Delta ambulatory time before/after self-admin0.10.10.30.2-0.20.20.2-0.1-0.3-0.0-0.6
Parametrial fat weight0.30.62.10.3-0.3-0.50.31.4-0.81.10.7
Pavlov. Cond. lever latency2.83.56.51.7-1.70.7-1.51.8-2.22.52.1
Pavlov. Cond. magazine entry latency0.20.30.6-0.70.7-0.50.8-0.10.6-0.5-0.3
Pavlov. Cond. change in total contacts1.01.11.7-1.21.2-0.81.1-0.61.3-1.2-0.7
Pavlov. Cond. index score1.62.03.0-1.61.6-1.11.5-0.81.7-1.7-1.0
Pavlov. Cond. latency score1.82.23.4-1.61.6-1.01.5-1.01.8-1.8-1.2
Pavlov. Cond. lever contacts2.22.74.6-1.61.6-0.81.5-1.42.0-2.2-1.6
Pavlov. Cond. magazine entry number0.40.51.00.9-0.90.9-1.0-0.2-0.80.50.0
Pavlov. Cond. intertrial magazine entries0.60.71.80.4-0.40.9-0.5-1.30.1-0.7-1.3
Pavlov. Cond. lever-magazine prob. diff.1.62.03.1-1.61.6-1.11.5-0.81.8-1.7-0.9
Pavlov. Cond. response bias1.11.32.0-1.41.4-1.21.4-0.21.4-1.1-0.4
Pavlov. Cond. lever latency2.43.25.12.3-2.32.0-2.1-0.1-2.21.50.2
Pavlov. Cond. magazine entry latency1.01.22.5-1.21.2-1.61.31.20.70.10.9
Pavlov. Cond. change in total contacts1.62.54.1-2.02.0-2.01.90.51.8-0.90.3
Pavlov. Cond. index score1.92.54.0-2.02.0-2.02.00.51.8-0.90.2
Pavlov. Cond. latency score2.02.74.8-2.02.0-2.22.10.91.6-0.70.5
Pavlov. Cond. lever contacts2.73.86.0-2.42.4-2.12.3-0.02.4-1.7-0.2
Pavlov. Cond. magazine entry number1.11.32.71.1-1.11.6-1.3-1.4-0.6-0.3-1.1
Pavlov. Cond. intertrial magazine entries0.30.51.4-0.10.10.40.0-1.10.4-0.9-1.2
Pavlov. Cond. lever-magazine prob. diff.1.72.33.7-1.91.9-1.91.90.51.7-0.90.2
Pavlov. Cond. response bias1.92.64.2-2.02.0-1.81.90.11.9-1.3-0.2
Time in closed arm before self-admin1.01.32.7-1.21.2-1.61.61.20.50.10.7
Time in closed arm after self-admin0.50.61.1-0.70.7-0.20.6-0.80.7-1.0-1.0
Time in open arm before self-admin0.70.82.2-0.40.40.4-0.1-1.50.8-1.3-1.2
Time in open arm after self-admin0.70.81.5-0.90.9-1.21.20.90.40.10.7
Bone: periosteal estimation1.32.75.4-1.71.7-2.31.81.61.20.01.7
Bone: periosteal perimeter0.61.13.2-0.20.2-1.00.41.7-0.31.11.8
Bone: post-yield work0.60.91.4-1.21.2-1.11.20.11.1-0.80.0
Progressive ratio test 1 active lever presses0.91.11.61.2-1.20.5-1.00.8-1.01.21.1
Progressive ratio test 1 breakpoint0.91.11.71.3-1.30.5-1.00.7-1.11.31.0
Progressive ratio test 1 inactive lever presses1.31.83.31.5-1.50.5-1.01.3-1.51.81.1
Progressive ratio test 2 active lever presses0.70.91.61.2-1.20.7-0.90.4-1.11.00.4
Progressive ratio test 2 breakpoint0.91.12.01.4-1.40.9-1.00.3-1.21.00.3
Progressive ratio test 2 inactive lever presses1.21.93.61.9-1.91.5-1.4-0.1-1.61.0-0.4
Incentive Sensitization - Responses0.60.91.71.3-1.31.0-0.80.0-1.30.7-0.4
Incentive Sensitization - Breakpoint0.81.01.91.4-1.41.1-0.9-0.0-1.30.8-0.4
Sum of active levers in priming session hrs 5-60.50.51.6-0.10.1-0.70.21.1-0.10.71.2
Progressive ratio0.30.50.9-0.70.7-1.00.70.80.40.10.9
Food seeking constrained by brief footshock0.20.20.4-0.50.5-0.60.60.40.3-0.10.4
Seeking ratio, punishment vs. effort0.00.00.20.1-0.10.10.1-0.2-0.1-0.1-0.5
Retroperitoneal fat weight1.56.415.7-1.51.5-3.32.34.00.31.83.4
Reaction time number correct0.61.12.71.2-1.21.5-1.6-0.9-0.60.1-0.2
Reaction time mean minus median0.61.43.4-0.70.7-1.51.11.8-0.00.91.7
Reaction time mean minus median AUC0.40.92.70.0-0.0-0.80.41.6-0.61.21.5
Reaction time num false alarms1.31.85.80.1-0.11.2-0.4-2.10.3-1.4-2.4
Reaction time num false alarms AUC1.72.78.8-0.10.11.3-0.2-2.60.6-1.9-3.0
Reaction time trials correct on left0.61.12.71.2-1.21.5-1.6-0.9-0.60.1-0.2
Reaction time trials on left0.61.12.61.1-1.11.4-1.6-0.9-0.60.2-0.1
Reaction time mean1.01.53.7-0.80.8-1.61.31.90.00.81.5
Reaction time mean AUC0.81.33.3-0.70.7-1.51.21.8-0.10.81.3
Median of all reaction times0.60.82.1-0.60.6-1.21.01.4-0.10.71.0
Reaction time omissions0.50.71.9-0.30.3-0.90.71.4-0.30.81.2
Reaction time false alarm rate1.42.06.2-0.80.80.30.6-1.91.0-1.9-2.5
Reaction time premature initiation rate0.10.10.40.1-0.1-0.1-0.00.4-0.20.30.6
Reaction time premature initiations0.30.51.10.9-0.90.7-1.0-0.1-0.60.50.5
Std. dev. reaction times1.12.04.0-1.41.4-2.01.71.70.60.31.4
Reaction time trials completed0.61.12.61.1-1.11.4-1.6-0.9-0.60.2-0.1
Reaction time trials AUC0.51.02.61.1-1.11.4-1.6-0.9-0.50.1-0.1
Run reversals in cocaine runway, females1.61.62.9-1.71.7-1.41.70.21.1-0.9-0.0
Run reversals in cocaine runway, males0.20.20.50.4-0.4-0.0-0.20.7-0.50.70.6
Latency to leave start box in cocaine runway0.70.81.80.6-0.61.2-1.0-1.3-0.1-0.6-1.1
Latency to leave start box in cocaine runway, F0.50.61.20.9-0.91.0-1.1-0.7-0.40.0-0.5
Latency to leave start box in cocaine runway, M0.30.30.9-0.20.20.30.1-0.80.2-0.7-0.9
Std. dev. time between licks in bursts2.43.35.7-2.12.1-1.61.8-0.82.4-2.0-0.8
Total sessions with >9 infusions2.02.43.71.9-1.90.8-1.51.1-1.71.91.2
Short access day 1 total inactive lever presses1.31.72.71.6-1.60.8-1.20.9-1.51.60.5
Short access day 10 total inactive lever presses0.40.92.2-1.11.1-1.31.51.00.5-0.00.3
Short access day 1 total infusions2.63.56.32.5-2.51.5-2.10.6-1.91.91.1
Short access day 10 total infusions0.81.01.71.1-1.10.3-0.90.9-0.91.31.1
Short access total infusions2.63.35.32.3-2.31.2-1.91.0-1.92.01.4
Short access day 1 locomotion0.50.61.90.0-0.0-0.70.21.2-0.20.81.4
Short access day 10 total locomotion2.34.28.12.1-2.10.3-1.42.3-2.02.92.3
Short access total locomotion2.63.15.52.0-2.00.6-1.41.7-1.92.31.7
One hour access (0.3 mA shock)0.60.61.11.0-1.00.6-0.90.3-0.80.90.6
Compulsive drug intake0.10.10.2-0.30.3-0.40.10.40.20.20.4
One hour access (shock baseline)0.10.20.40.6-0.60.5-0.5-0.1-0.40.30.1
Social response proportion0.50.51.5-0.30.3-0.90.61.2-0.10.61.1
Social responses1.01.32.4-1.41.4-1.31.1-0.11.6-1.10.3
Social time1.72.44.6-1.41.4-2.11.71.90.70.51.9
Soleus weight0.00.10.20.1-0.10.2-0.4-0.20.1-0.00.3
Bone: stiffness0.81.22.1-1.31.3-1.31.40.01.3-0.9-0.2
Tibialis anterior weight1.65.57.42.6-2.61.8-2.71.2-2.62.72.1
Time to tail flick, vehicle, before self-admin2.93.05.22.3-2.31.6-1.90.5-2.01.80.2
Time to tail flick, vehicle, after self-admin0.10.10.6-0.10.10.10.3-0.2-0.2-0.2-0.8
Time to tail flick, test, before self-admin0.40.40.8-0.80.8-0.70.90.10.6-0.5-0.3
Time to tail flick, test, after self-admin1.61.72.9-1.41.4-0.51.2-1.11.3-1.7-1.3
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.40.4-0.30.50.00.2-0.2-0.0
Delta time to tail flick, test, before/after SA1.01.02.0-0.80.80.00.6-1.30.8-1.4-1.4
Tibia length2.67.319.4-1.31.3-3.21.74.20.12.24.4
Ambulatory time before self-admin0.71.12.21.0-1.00.3-0.81.1-1.21.51.1
Ambulatory time after self-admin1.21.42.61.3-1.30.5-0.71.2-1.61.60.8
Bone: tissue strength0.00.00.00.0-0.00.1-0.0-0.2-0.0-0.1-0.2
Total heroin consumption0.10.20.4-0.20.2-0.50.30.7-0.00.30.6
Bone: trabecular number0.61.02.0-1.11.1-1.41.20.90.8-0.10.8
Bone: trabecular spacing1.62.23.81.8-1.81.9-1.7-0.7-1.60.7-0.7
Bone: trabecular thickness4.15.17.8-2.72.7-2.32.6-0.52.8-2.3-0.7
Bone: trabecular tissue density0.00.10.2-0.30.3-0.40.40.10.2-0.10.0
Water consumed over 24 hours2.23.06.1-1.61.6-2.52.32.00.80.31.4
Number of responses in last shaping day0.30.30.60.8-0.80.7-0.6-0.2-0.60.2-0.3