Ecrg4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ecrg4 0.06 0.05 9.9e-06 0.05 0.05 0.05 0.04 4.6e-06 7.2e-06 6.5e-06 1.2e-05
2 Liver gene expression Ecrg4 0.18 0.13 9.0e-14 0.08 0.07 0.07 0.08 5.1e-09 1.7e-08 4.3e-08 7.2e-09
3 Adipose gene expression Ecrg4 0.54 0.17 0.0e+00 0.24 0.25 0.25 0.25 6.1e-27 2.1e-27 2.1e-27 1.1e-27

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density5.28.89.0-2.92.93.0
Area under the delay curve0.30.30.50.5-0.4-0.7
BMI with tail2.88.99.73.0-3.1-2.8
BMI without tail0.00.10.1-0.30.30.4
Body weight0.10.50.60.7-0.7-0.7
Weight adjusted by age0.20.20.50.7-0.4-0.3
Bone surface0.40.61.0-0.70.71.0
Bone volume2.23.84.3-1.91.92.1
Breakpoint value in progressive ratio session0.30.30.5-0.70.50.4
Number of licking bursts0.30.40.4-0.60.60.6
Context. condit. distance diff. score1.11.31.7-1.11.30.9
Locomotion velocity, session 10.10.10.20.1-0.1-0.5
Locomotion distance, session 11.11.41.91.1-1.1-1.4
Locomotion velocity, session 23.64.24.72.0-2.2-2.0
Locomotion distance, session 23.75.25.42.3-2.3-2.2
Locomotion velocity, session 30.20.20.2-0.50.40.4
Locomotion distance, session 30.10.10.1-0.30.30.2
Stereotopy head waving bouts, day 30.30.40.4-0.60.50.7
Stereotopy head waving duration, day 30.10.20.2-0.50.40.4
Locomotion velocity, session 70.20.20.30.5-0.5-0.4
Locomotion distance, session 70.70.91.21.1-0.9-0.9
Stereotopy head waving bouts, day 70.10.10.1-0.30.30.2
Stereotopy head waving duration, day 70.10.20.2-0.50.50.3
Locomotion velocity, session 80.00.00.0-0.10.00.1
Locomotion distance, session 80.60.81.01.0-0.8-1.0
Degree of sensitization distance1.61.61.81.3-1.2-1.2
Degree of sensitization stereotypy0.00.00.0-0.10.20.1
Conditioned locomotion0.00.00.1-0.30.1-0.1
Cocaine response after cond. corrected0.91.01.20.9-1.0-1.1
Cocaine response after cond. not corrected0.80.81.10.8-0.9-1.0
Cocaine response before conditioning0.00.00.0-0.10.10.1
Saline control response0.20.20.30.3-0.4-0.6
Bone: connectivity density1.11.72.1-1.21.21.5
Bone: cortical apparent density2.43.13.51.9-1.8-1.7
Bone: cortical area0.20.30.30.6-0.5-0.4
Bone: cortical porosity1.51.71.7-1.31.31.3
Bone: cortical porosity1.92.12.2-1.51.51.4
Bone: cortical thickness0.30.50.50.7-0.7-0.6
Bone: cortical thickness0.10.10.10.3-0.3-0.3
Bone: cortical tissue density2.22.93.31.8-1.7-1.6
Condit. Reinf. active minus inactive responses0.50.51.00.6-0.4-1.0
Condit. Reinf. active-inactive response ratio0.30.30.70.3-0.1-0.9
Condit. Reinf. active responses0.30.40.60.6-0.3-0.8
Condit. Reinf. inactive responses0.50.60.60.8-0.6-0.8
Incentive salience index mean0.10.10.20.20.0-0.5
Condit. Reinf. lever presses0.30.40.6-0.60.80.4
Condit. Reinf. active minus inactive responses0.40.50.8-0.90.80.5
Condit. Reinf. active-inactive response ratio1.41.52.0-1.41.21.0
Condit. Reinf. active responses0.00.10.20.1-0.2-0.4
Condit. Reinf. inactive responses0.81.01.31.1-1.0-0.9
Condit. Reinf. lever presses0.40.50.6-0.70.80.7
Condit. Reinf. lever reinforcers received0.10.20.30.3-0.4-0.6
Conditioned reinforcement - actives0.20.20.4-0.30.60.3
Conditioned reinforcement - inactives0.30.30.5-0.70.60.4
Conditioned locomotion1.01.21.31.2-1.1-1.0
Patch foraging indifference point 0 sec0.10.20.40.4-0.60.1
Patch foraging indifference point AUC1.41.61.81.3-1.3-1.2
Delay disc. indifference point, 0s delay0.30.30.50.7-0.5-0.5
Delay disc. indifference point, 16s delay0.10.20.2-0.50.50.2
Delay disc. indifference point, 2s delay0.40.40.60.8-0.5-0.6
Delay disc. indifference point, 24s delay0.10.10.2-0.30.50.2
Delay disc. indifference point, 4s delay0.91.01.11.1-0.8-1.1
Delay disc. indifference point, 8s delay0.00.00.10.1-0.1-0.3
Indifference point function ln k0.20.20.30.5-0.5-0.5
Indifference point function log k0.20.20.30.5-0.5-0.5
Patch foraging total patch changes 0 sec0.30.50.90.7-0.9-0.2
Patch foraging total patch changes 12 sec0.00.00.1-0.0-0.30.2
Patch foraging total patch changes 18 sec1.41.92.61.4-1.6-1.0
Patch foraging total patch changes 24 sec0.20.30.50.5-0.7-0.2
Patch foraging total patch changes 6 sec0.00.10.10.3-0.10.3
Patch foraging time to switch 0 sec0.91.41.7-1.31.11.2
Patch foraging water rate 0 sec0.81.41.51.2-1.2-1.1
Patch foraging water rate 12 sec0.00.10.10.4-0.10.1
Patch foraging water rate 18 sec0.50.60.7-0.70.80.8
Patch foraging water rate 24 sec0.00.00.00.20.1-0.1
Patch foraging water rate 6 sec0.00.00.10.30.00.1
Seeking ratio, delayed vs. immediate footshock0.30.30.4-0.60.70.5
Distance traveled before self-admin0.20.20.4-0.40.40.6
Distance traveled after self-admin4.14.55.1-2.31.92.2
Extensor digitorum longus weight6.927.129.85.5-5.1-5.0
Bone: elastic displacement0.70.81.1-0.80.81.1
Bone: elastic work0.50.60.7-0.80.70.8
Bone: endosteal estimation0.00.00.0-0.10.10.2
Bone: endosteal perimeter0.00.00.0-0.1-0.00.1
Epididymis fat weight0.00.00.1-0.10.00.2
Delta time in closed arm before/after self-admin0.80.81.2-0.70.81.1
Delta time in open arm before/after self-admin0.10.10.10.10.40.1
Diff in mean of infusions in LGA sessions0.80.90.9-1.01.01.0
Delay discount exponential model param0.30.30.5-0.50.30.7
Extinction: sum of active levers before priming0.10.10.2-0.5-0.20.2
Active lever presses in extinction session 61.61.61.91.1-1.3-1.4
Bone: final force0.20.40.40.6-0.6-0.6
Bone: final moment0.20.40.40.6-0.6-0.6
Food consumed during 24 hour testing period0.91.11.21.0-1.1-1.0
Glucose0.00.10.2-0.40.10.1
Heart weight0.50.71.01.0-0.7-0.7
Delay discount hyperbolic model param0.60.60.9-0.80.60.9
Intermittent access intake day 1-15 change0.50.50.8-0.80.90.5
Intermittent access intake escalation1.11.11.4-1.11.20.8
Intermittent access intake escalation 21.51.52.2-1.21.50.9
Intermitt. access day 1 inactive lever presses0.10.10.1-0.40.20.3
Intermitt. access day 15 inactive lever presses0.60.60.8-0.70.90.7
Intermitt. access escalation Index0.10.10.30.2-0.0-0.5
Intermittent access day 1 total infusions0.00.00.00.2-0.1-0.2
Intermittent access day 15 total infusions0.70.71.0-0.91.00.6
Intermittent access terminal intake (last 3 days)0.10.10.3-0.20.60.2
Intermittent access total infusions0.20.20.2-0.40.50.3
Intermittent access day 1 locomotion0.10.10.10.3-0.2-0.2
Intermittent access day 15 total locomotion0.00.00.0-0.1-0.0-0.1
Intermittent access total locomotion0.00.00.10.1-0.2-0.2
Intermittent access standard deviation0.80.80.9-1.00.90.8
Left kidney weight0.00.10.1-0.20.30.4
Right kidney weight0.00.10.1-0.30.10.3
Cocaine induced anxiety1.41.71.81.3-1.3-1.3
Post-drug Anxiety2.83.13.51.7-1.8-1.9
Baseline Anxiety0.00.00.1-0.00.1-0.3
Tail length1.33.84.4-2.02.11.7
Length with tail0.41.41.6-1.31.30.9
Length without tail1.22.72.91.6-1.7-1.7
Times rat made contact with spout0.40.50.6-0.80.70.7
Lifetime Intake0.00.00.0-0.20.10.0
Liver weight, left0.30.50.9-0.50.60.9
Liver weight, right0.20.30.4-0.60.40.7
Locomotor activity0.20.30.3-0.40.60.6
Locomotor testing distance1.52.52.9-1.41.71.7
Locomotor testing rearing2.23.43.9-1.92.01.7
Locomotion in novel chamber7.79.59.73.1-3.0-3.1
Locomotion in novel chamber post-restriction3.94.74.92.1-2.2-2.2
Fecal boli incidents, locomotor time 12.72.93.21.6-1.8-1.7
Change in fecal boli incidents, locomotor task0.10.10.2-0.20.30.4
Time >=10cm from walls, locomotor time 11.81.82.01.4-1.3-1.3
Bouts of movement, locomotor time 110.611.511.83.4-3.4-3.4
Total resting periods, locomotor time 110.711.812.03.4-3.4-3.5
Rest time, locomotor task time 11.01.11.21.1-1.0-1.1
Distance moved, locomotor task time 10.20.20.4-0.40.40.6
Vertical activity count, locomotor time 11.71.82.0-1.41.31.3
Time >=10cm from walls, locomotor time 20.00.00.00.10.10.1
Bouts of movement, locomotor time 23.13.33.41.8-1.8-1.8
Total resting periods, locomotor time 22.72.93.11.7-1.8-1.6
Rest time, locomotor task time 20.10.10.1-0.30.20.2
Distance moved, locomotor task time 20.30.40.60.8-0.5-0.5
Vertical activity count, locomotor time 20.40.40.50.6-0.5-0.7
Light reinforcement 14.07.37.92.8-2.8-2.5
Light reinforcement 21.41.92.41.5-1.5-1.0
Bone: marrow area0.00.00.0-0.00.10.1
Bone: maximum diameter0.00.10.1-0.20.30.4
Bone: maximum force0.20.40.40.6-0.6-0.6
Bone: maximum moment0.20.40.40.7-0.6-0.6
Mean time between licks in bursts0.91.31.61.3-1.3-0.8
Mean num. licks in bursts0.30.30.40.5-0.6-0.6
Cd content in liver0.10.10.1-0.20.30.3
Co content in liver0.30.40.6-0.80.70.2
Cu content in liver0.50.60.9-0.90.90.3
Fe content in liver3.13.74.3-2.11.81.8
K content in liver0.90.91.21.0-1.1-0.7
Mg content in liver0.10.10.20.3-0.4-0.1
Mn content in liver0.20.20.20.4-0.5-0.4
Na content in liver1.31.42.0-1.11.01.4
Rb content in liver3.64.55.12.1-2.0-2.3
Se content in liver0.30.30.40.6-0.6-0.5
Sr content in liver0.00.00.00.2-0.1-0.1
Zn content in liver0.00.00.1-0.30.1-0.0
Bone: minimum diameter0.40.81.11.0-0.9-0.8
Time in familiar zone, hab. session 10.00.00.0-0.1-0.0-0.2
Time in novel zone, hab. session 11.11.01.2-0.91.01.1
Total zone transitions, hab. session 10.10.20.3-0.50.30.5
Total locomotion distance, hab. session 10.71.01.31.0-1.1-0.9
Locomotion velocity, hab. session 10.60.81.10.8-1.0-0.8
Time in familiar zone, hab. session 20.60.60.7-0.70.80.8
Time in novel zone, hab. session 20.10.10.10.2-0.2-0.3
Total zone transitions, hab. session 20.40.50.50.6-0.7-0.7
Total locomotion distance, hab. session 21.62.12.31.4-1.5-1.5
Locomotion velocity, hab. session 21.31.81.91.2-1.4-1.4
Novel to familiar place preference ratio0.10.10.10.3-0.3-0.3
Novelty place preference0.00.00.10.2-0.2-0.3
Time in novel zone, NPP test0.00.00.0-0.00.0-0.1
Total zone transitions, NPP test0.40.60.90.7-0.7-0.9
Total locomotion distance, NPP test0.71.01.10.9-1.0-1.0
Locomotion velocity, NPP test1.01.41.61.1-1.3-1.2
Intraocular pressure2.43.43.81.7-1.9-2.0
Delta distance traveled before/after self-admin0.80.91.2-1.10.80.9
Delta ambulatory time before/after self-admin0.60.70.9-1.00.70.8
Parametrial fat weight0.10.20.40.6-0.3-0.4
Pavlov. Cond. lever latency0.30.40.50.7-0.6-0.5
Pavlov. Cond. magazine entry latency0.10.10.1-0.30.40.2
Pavlov. Cond. change in total contacts0.30.30.40.6-0.5-0.7
Pavlov. Cond. index score0.20.20.2-0.50.50.4
Pavlov. Cond. latency score0.30.30.4-0.60.60.5
Pavlov. Cond. lever contacts0.10.20.2-0.50.40.3
Pavlov. Cond. magazine entry number0.70.80.90.9-1.0-0.8
Pavlov. Cond. intertrial magazine entries0.50.60.80.8-0.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.10.1-0.0
Pavlov. Cond. response bias0.10.10.1-0.30.30.2
Pavlov. Cond. lever latency0.60.81.00.8-1.0-0.9
Pavlov. Cond. magazine entry latency0.60.70.9-0.81.00.8
Pavlov. Cond. change in total contacts0.60.91.0-0.90.91.0
Pavlov. Cond. index score0.50.70.8-0.80.90.8
Pavlov. Cond. latency score0.40.50.6-0.60.80.7
Pavlov. Cond. lever contacts1.72.32.7-1.31.61.6
Pavlov. Cond. magazine entry number1.41.71.81.3-1.3-1.3
Pavlov. Cond. intertrial magazine entries4.05.25.42.3-2.3-2.3
Pavlov. Cond. lever-magazine prob. diff.0.40.50.6-0.60.80.7
Pavlov. Cond. response bias2.33.13.4-1.61.91.8
Time in closed arm before self-admin0.10.10.2-0.0-0.2-0.4
Time in closed arm after self-admin0.90.91.1-1.10.80.9
Time in open arm before self-admin0.30.40.40.7-0.6-0.5
Time in open arm after self-admin0.30.30.5-0.40.70.6
Bone: periosteal estimation0.00.00.00.00.00.1
Bone: periosteal perimeter0.00.00.00.1-0.2-0.0
Bone: post-yield work0.10.20.3-0.40.50.4
Progressive ratio test 1 active lever presses0.70.70.80.9-0.7-0.9
Progressive ratio test 1 breakpoint0.70.70.90.9-0.7-0.9
Progressive ratio test 1 inactive lever presses0.10.10.1-0.20.30.3
Progressive ratio test 2 active lever presses0.30.30.4-0.60.60.3
Progressive ratio test 2 breakpoint0.00.00.1-0.20.3-0.1
Progressive ratio test 2 inactive lever presses0.80.91.1-1.01.00.8
Incentive Sensitization - Responses1.21.21.5-1.21.20.9
Incentive Sensitization - Breakpoint0.91.01.2-1.11.10.7
Sum of active levers in priming session hrs 5-60.30.30.4-0.50.40.6
Progressive ratio3.13.54.31.7-1.8-2.1
Food seeking constrained by brief footshock0.00.00.0-0.0-0.0-0.1
Seeking ratio, punishment vs. effort1.62.02.4-1.31.41.6
Retroperitoneal fat weight0.30.91.11.1-0.9-0.9
Reaction time number correct1.11.61.71.3-1.2-1.3
Reaction time mean minus median1.92.52.7-1.61.51.5
Reaction time mean minus median AUC1.72.22.6-1.51.61.4
Reaction time num false alarms2.22.93.21.8-1.7-1.7
Reaction time num false alarms AUC3.04.14.62.1-2.0-1.9
Reaction time trials correct on left1.11.61.71.3-1.2-1.3
Reaction time trials on left1.01.41.61.3-1.1-1.2
Reaction time mean2.53.54.1-2.01.91.7
Reaction time mean AUC1.82.42.7-1.61.61.4
Median of all reaction times1.82.53.0-1.71.61.4
Reaction time omissions1.31.72.3-1.51.21.2
Reaction time false alarm rate0.81.11.21.1-1.1-1.0
Reaction time premature initiation rate0.10.10.1-0.20.40.2
Reaction time premature initiations0.10.20.20.5-0.3-0.5
Std. dev. reaction times3.24.54.9-2.22.12.1
Reaction time trials completed1.01.41.61.3-1.1-1.2
Reaction time trials AUC1.01.41.61.2-1.1-1.2
Run reversals in cocaine runway, females0.50.50.70.5-0.7-0.8
Run reversals in cocaine runway, males0.40.30.40.6-0.6-0.6
Latency to leave start box in cocaine runway2.62.83.01.7-1.7-1.6
Latency to leave start box in cocaine runway, F0.00.00.10.2-0.3-0.1
Latency to leave start box in cocaine runway, M6.26.06.12.4-2.5-2.4
Std. dev. time between licks in bursts0.60.71.01.0-0.9-0.6
Total sessions with >9 infusions1.92.12.31.4-1.4-1.5
Short access day 1 total inactive lever presses0.40.50.6-0.60.70.7
Short access day 10 total inactive lever presses0.50.60.7-0.80.80.6
Short access day 1 total infusions0.00.00.00.1-0.1-0.1
Short access day 10 total infusions0.10.10.10.3-0.1-0.4
Short access total infusions0.40.50.50.7-0.7-0.7
Short access day 1 locomotion0.30.30.40.6-0.6-0.5
Short access day 10 total locomotion0.20.20.3-0.30.40.6
Short access total locomotion0.60.60.70.8-0.8-0.7
One hour access (0.3 mA shock)0.40.40.7-0.60.80.4
Compulsive drug intake1.61.61.8-1.21.41.3
One hour access (shock baseline)0.00.00.0-0.20.2-0.2
Social response proportion0.00.00.0-0.1-0.0-0.2
Social responses0.50.71.0-0.91.00.6
Social time4.25.56.2-2.52.32.3
Soleus weight0.92.63.71.9-1.6-1.3
Bone: stiffness0.30.40.50.6-0.6-0.7
Tibialis anterior weight2.17.27.82.8-2.7-2.5
Time to tail flick, vehicle, before self-admin0.10.10.20.3-0.4-0.4
Time to tail flick, vehicle, after self-admin0.00.00.0-0.20.0-0.1
Time to tail flick, test, before self-admin0.80.70.91.0-0.8-0.8
Time to tail flick, test, after self-admin3.13.24.02.0-1.6-1.8
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.30.20.2
Delta time to tail flick, test, before/after SA0.20.20.30.6-0.4-0.4
Tibia length0.10.30.3-0.50.60.5
Ambulatory time before self-admin0.00.00.10.00.20.3
Ambulatory time after self-admin0.80.91.1-1.00.81.0
Bone: tissue strength0.40.40.50.7-0.5-0.7
Total heroin consumption0.10.10.20.2-0.3-0.4
Bone: trabecular number4.26.66.8-2.62.52.6
Bone: trabecular spacing3.14.14.52.0-2.0-2.1
Bone: trabecular thickness6.07.27.3-2.72.72.6
Bone: trabecular tissue density0.20.20.3-0.50.50.3
Water consumed over 24 hours0.30.40.60.6-0.6-0.8
Number of responses in last shaping day0.30.30.6-0.50.80.4