Hub : Genes

Ecrg4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ecrg4 0.06 0.05 4.8e-06 0.05 0.05 0.05 0.05 1.9e-06 1.7e-06 6.2e-06 6.2e-06
2 Liver gene expression Ecrg4 0.13 0.09 1.7e-12 0.07 0.07 0.07 0.07 2.9e-08 4.4e-08 3.2e-08 4.3e-08
3 Adipose gene expression Ecrg4 0.58 0.17 0.0e+00 0.25 0.24 0.24 0.25 3.0e-27 1.1e-26 6.2e-26 9.0e-28

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density5.79.810.13.0-3.23.2
Area under the delay curve0.30.40.7-0.40.6-0.8
BMI with tail1.45.06.1-2.52.3-1.9
BMI without tail0.00.10.2-0.30.5-0.3
Body weight0.10.40.4-0.60.6-0.7
Weight adjusted by age0.20.41.0-1.00.3-0.1
Bone surface0.50.81.30.7-0.81.1
Bone volume2.54.45.12.0-2.12.2
Breakpoint value in progressive ratio session0.80.91.31.1-0.90.8
Number of licking bursts0.20.30.60.8-0.40.4
Context. condit. distance diff. score0.70.91.01.0-1.00.8
Locomotion velocity, session 10.10.10.20.00.1-0.5
Locomotion distance, session 11.51.92.5-1.31.3-1.6
Locomotion velocity, session 23.84.45.1-2.32.1-2.0
Locomotion distance, session 24.15.75.8-2.42.4-2.3
Locomotion velocity, session 30.00.10.10.2-0.20.2
Locomotion distance, session 30.10.10.10.3-0.30.3
Stereotopy head waving bouts, day 30.30.40.40.7-0.60.6
Stereotopy head waving duration, day 30.30.30.40.6-0.60.4
Locomotion velocity, session 70.40.40.7-0.90.6-0.5
Locomotion distance, session 70.60.81.1-1.00.8-0.8
Stereotopy head waving bouts, day 70.10.10.20.4-0.40.3
Stereotopy head waving duration, day 70.10.10.20.4-0.40.2
Locomotion velocity, session 80.00.00.1-0.20.1-0.1
Locomotion distance, session 80.91.31.5-1.21.1-1.1
Degree of sensitization distance1.11.11.4-1.21.0-1.0
Degree of sensitization stereotypy0.00.00.00.0-0.10.0
Conditioned locomotion0.10.10.1-0.10.2-0.4
Cocaine response after cond. corrected0.80.91.2-0.81.0-1.1
Cocaine response after cond. not corrected0.70.81.1-0.80.9-1.0
Cocaine response before conditioning0.00.00.0-0.1-0.20.1
Saline control response0.60.80.9-0.90.8-0.9
Bone: connectivity density1.21.92.21.3-1.31.5
Bone: cortical apparent density2.33.24.1-2.01.7-1.5
Bone: cortical area0.10.20.3-0.50.3-0.3
Bone: cortical porosity2.22.42.41.5-1.51.6
Bone: cortical porosity2.42.62.81.6-1.71.6
Bone: cortical thickness0.10.20.3-0.50.4-0.4
Bone: cortical thickness0.20.20.3-0.60.4-0.4
Bone: cortical tissue density2.02.73.6-1.91.6-1.4
Condit. Reinf. active minus inactive responses0.30.41.0-0.10.4-1.0
Condit. Reinf. active-inactive response ratio0.30.30.80.10.2-0.9
Condit. Reinf. active responses0.30.40.8-0.20.5-0.9
Condit. Reinf. inactive responses0.70.90.9-0.91.0-0.9
Incentive salience index mean0.10.10.30.10.1-0.5
Condit. Reinf. lever presses0.10.10.20.5-0.40.2
Condit. Reinf. active minus inactive responses0.20.30.60.8-0.60.2
Condit. Reinf. active-inactive response ratio1.01.21.71.3-1.10.8
Condit. Reinf. active responses0.10.10.2-0.20.3-0.5
Condit. Reinf. inactive responses0.81.11.5-1.21.0-0.9
Condit. Reinf. lever presses0.40.50.70.8-0.70.7
Condit. Reinf. lever reinforcers received0.20.30.4-0.30.5-0.6
Conditioned reinforcement - actives0.10.10.1-0.20.4-0.3
Conditioned reinforcement - inactives0.10.10.2-0.40.3-0.4
Conditioned locomotion1.11.42.2-1.51.1-0.9
Patch foraging indifference point 0 sec0.10.20.3-0.50.30.3
Patch foraging indifference point AUC0.71.01.0-1.01.0-0.9
Delay disc. indifference point, 0s delay0.40.40.6-0.80.6-0.5
Delay disc. indifference point, 16s delay0.20.20.50.7-0.40.1
Delay disc. indifference point, 2s delay0.30.30.4-0.60.6-0.5
Delay disc. indifference point, 24s delay0.10.10.20.5-0.2-0.0
Delay disc. indifference point, 4s delay0.80.81.0-0.90.8-1.0
Delay disc. indifference point, 8s delay0.00.00.10.10.1-0.3
Indifference point function ln k0.20.30.3-0.60.5-0.5
Indifference point function log k0.20.30.3-0.60.5-0.5
Patch foraging total patch changes 0 sec0.20.30.7-0.80.60.0
Patch foraging total patch changes 12 sec0.00.10.2-0.1-0.00.4
Patch foraging total patch changes 18 sec0.81.21.5-1.21.2-0.8
Patch foraging total patch changes 24 sec0.20.30.5-0.70.6-0.2
Patch foraging total patch changes 6 sec0.10.10.2-0.2-0.00.5
Patch foraging time to switch 0 sec0.61.21.31.1-1.11.1
Patch foraging water rate 0 sec0.51.01.2-0.91.1-1.0
Patch foraging water rate 12 sec0.00.10.1-0.20.4-0.0
Patch foraging water rate 18 sec0.40.60.70.8-0.80.8
Patch foraging water rate 24 sec0.00.00.00.1-0.20.0
Patch foraging water rate 6 sec0.00.00.0-0.00.10.0
Seeking ratio, delayed vs. immediate footshock0.30.30.40.4-0.70.6
Distance traveled before self-admin1.52.02.41.3-1.41.6
Distance traveled after self-admin5.06.27.02.2-2.62.7
Extensor digitorum longus weight6.927.029.5-5.45.1-5.0
Bone: elastic displacement1.72.02.31.3-1.31.5
Bone: elastic work0.91.21.31.0-1.11.1
Bone: endosteal estimation0.00.00.00.0-0.10.1
Bone: endosteal perimeter0.00.00.0-0.0-0.10.0
Epididymis fat weight0.20.70.9-1.00.7-0.7
Delta time in closed arm before/after self-admin0.70.70.90.8-0.70.9
Delta time in open arm before/after self-admin0.10.10.20.3-0.40.3
Diff in mean of infusions in LGA sessions0.20.30.50.7-0.40.5
Delay discount exponential model param0.40.40.70.4-0.60.9
Extinction: sum of active levers before priming0.70.80.80.8-0.90.9
Active lever presses in extinction session 60.90.91.1-0.90.9-1.0
Bone: final force0.10.10.2-0.50.2-0.3
Bone: final moment0.10.10.2-0.50.2-0.3
Food consumed during 24 hour testing period0.81.11.2-1.01.0-1.1
Glucose0.10.20.30.6-0.30.3
Heart weight0.00.00.1-0.10.3-0.2
Delay discount hyperbolic model param0.50.50.90.5-0.70.9
Intermittent access intake day 1-15 change0.40.71.00.8-1.00.7
Intermittent access intake escalation0.51.01.31.0-1.10.9
Intermittent access intake escalation 21.92.22.51.6-1.61.3
Intermitt. access day 1 inactive lever presses0.00.00.10.0-0.30.2
Intermitt. access day 15 inactive lever presses0.00.00.1-0.20.1-0.0
Intermitt. access escalation Index0.10.10.10.4-0.4-0.2
Intermittent access day 1 total infusions0.20.30.5-0.10.7-0.6
Intermittent access day 15 total infusions0.30.40.70.8-0.60.4
Intermittent access terminal intake (last 3 days)0.00.00.10.3-0.10.0
Intermittent access total infusions0.10.10.20.4-0.10.0
Intermittent access day 1 locomotion0.50.70.8-0.70.9-0.8
Intermittent access day 15 total locomotion0.20.30.3-0.50.6-0.6
Intermittent access total locomotion0.50.60.8-0.70.9-0.8
Intermittent access standard deviation0.20.40.40.7-0.70.6
Left kidney weight0.10.50.70.9-0.60.7
Right kidney weight0.00.10.2-0.40.3-0.3
Cocaine induced anxiety0.10.10.1-0.40.2-0.4
Post-drug Anxiety1.31.41.6-1.31.1-1.2
Baseline Anxiety1.31.51.8-1.11.2-1.3
Tail length0.62.23.51.9-1.41.1
Length with tail0.41.62.31.5-1.30.9
Length without tail0.00.10.2-0.40.3-0.3
Times rat made contact with spout0.40.50.91.0-0.50.5
Lifetime Intake0.10.10.1-0.10.4-0.3
Liver weight, left0.00.10.10.3-0.10.3
Liver weight, right0.10.20.30.5-0.40.5
Locomotor activity0.30.50.60.7-0.80.7
Locomotor testing distance1.52.82.91.6-1.71.7
Locomotor testing rearing1.73.53.91.9-2.01.7
Locomotion in novel chamber7.09.09.2-3.03.0-2.9
Locomotion in novel chamber post-restriction2.64.24.7-2.22.0-2.0
Fecal boli incidents, locomotor time 11.42.02.1-1.31.4-1.4
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.20.5
Time >=10cm from walls, locomotor time 11.61.71.8-1.31.3-1.3
Bouts of movement, locomotor time 18.810.011.0-3.03.2-3.3
Total resting periods, locomotor time 19.610.611.5-3.13.3-3.4
Rest time, locomotor task time 10.60.70.9-0.60.9-1.0
Distance moved, locomotor task time 10.30.40.50.7-0.50.7
Vertical activity count, locomotor time 10.71.81.81.3-1.31.4
Time >=10cm from walls, locomotor time 20.00.00.00.1-0.00.2
Bouts of movement, locomotor time 22.53.94.1-2.02.0-2.0
Total resting periods, locomotor time 21.83.23.5-1.81.9-1.7
Rest time, locomotor task time 20.10.10.20.4-0.30.3
Distance moved, locomotor task time 20.20.30.4-0.50.6-0.5
Vertical activity count, locomotor time 20.40.50.6-0.70.6-0.8
Light reinforcement 12.86.99.2-3.02.6-2.2
Light reinforcement 21.21.82.8-1.71.4-0.9
Bone: marrow area0.00.00.0-0.1-0.0-0.0
Bone: maximum diameter0.10.10.20.2-0.30.4
Bone: maximum force0.20.30.5-0.70.4-0.5
Bone: maximum moment0.20.30.5-0.70.5-0.5
Mean time between licks in bursts0.61.41.9-1.41.3-0.8
Mean num. licks in bursts0.20.30.4-0.60.5-0.5
Cd content in liver2.22.43.21.8-1.61.2
Co content in liver0.60.71.21.1-0.90.4
Cu content in liver0.20.20.30.6-0.50.1
Fe content in liver2.93.53.81.9-1.82.0
K content in liver1.01.01.4-1.21.0-0.7
Mg content in liver0.00.00.1-0.30.00.1
Mn content in liver0.20.30.5-0.70.4-0.4
Na content in liver2.22.43.41.3-1.41.8
Rb content in liver7.08.29.1-2.82.8-3.0
Se content in liver1.01.11.3-1.01.1-1.0
Sr content in liver0.00.00.00.1-0.10.2
Zn content in liver0.20.20.30.5-0.50.3
Bone: minimum diameter0.50.91.2-1.10.9-0.8
Time in familiar zone, hab. session 10.00.00.10.2-0.1-0.0
Time in novel zone, hab. session 11.01.01.21.1-0.91.0
Total zone transitions, hab. session 10.10.10.1-0.0-0.30.4
Total locomotion distance, hab. session 10.81.11.3-1.11.0-1.0
Locomotion velocity, hab. session 10.60.91.2-1.10.9-0.8
Time in familiar zone, hab. session 20.50.60.70.9-0.70.7
Time in novel zone, hab. session 20.00.00.0-0.20.1-0.2
Total zone transitions, hab. session 20.60.70.9-0.80.8-0.9
Total locomotion distance, hab. session 21.52.02.5-1.31.4-1.6
Locomotion velocity, hab. session 21.31.82.1-1.21.3-1.5
Novel to familiar place preference ratio0.00.00.10.10.3-0.2
Novelty place preference0.00.00.00.10.2-0.2
Time in novel zone, NPP test0.00.00.10.40.00.0
Total zone transitions, NPP test0.50.71.1-0.70.7-1.0
Total locomotion distance, NPP test0.60.91.0-0.80.9-1.0
Locomotion velocity, NPP test1.01.41.4-1.21.2-1.2
Intraocular pressure3.24.74.9-2.12.1-2.2
Delta distance traveled before/after self-admin0.40.40.50.5-0.70.7
Delta ambulatory time before/after self-admin0.10.10.20.2-0.40.4
Parametrial fat weight0.30.81.3-1.10.8-0.7
Pavlov. Cond. lever latency0.60.70.9-0.80.9-0.7
Pavlov. Cond. magazine entry latency0.10.10.20.4-0.40.3
Pavlov. Cond. change in total contacts0.40.40.6-0.50.6-0.8
Pavlov. Cond. index score0.30.30.40.6-0.60.4
Pavlov. Cond. latency score0.40.50.60.7-0.80.6
Pavlov. Cond. lever contacts0.20.20.30.5-0.60.4
Pavlov. Cond. magazine entry number0.70.91.1-1.01.0-0.8
Pavlov. Cond. intertrial magazine entries0.30.40.6-0.50.6-0.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.2-0.20.0
Pavlov. Cond. response bias0.10.10.20.4-0.40.2
Pavlov. Cond. lever latency0.91.31.4-1.11.1-1.2
Pavlov. Cond. magazine entry latency0.80.91.10.8-1.01.0
Pavlov. Cond. change in total contacts0.71.11.31.0-1.01.1
Pavlov. Cond. index score0.70.91.10.8-0.91.0
Pavlov. Cond. latency score0.40.50.70.6-0.70.8
Pavlov. Cond. lever contacts1.72.32.41.5-1.51.6
Pavlov. Cond. magazine entry number1.21.41.7-1.11.2-1.3
Pavlov. Cond. intertrial magazine entries3.34.95.3-2.12.2-2.3
Pavlov. Cond. lever-magazine prob. diff.0.40.60.80.7-0.70.9
Pavlov. Cond. response bias2.53.43.81.7-1.91.9
Time in closed arm before self-admin0.10.10.20.5-0.20.0
Time in closed arm after self-admin1.11.11.41.2-1.01.0
Time in open arm before self-admin1.01.11.2-1.11.1-0.9
Time in open arm after self-admin0.10.10.10.1-0.30.3
Bone: periosteal estimation0.00.00.0-0.0-0.10.1
Bone: periosteal perimeter0.00.00.10.1-0.30.2
Bone: post-yield work0.00.00.0-0.0-0.0-0.1
Progressive ratio test 1 active lever presses1.21.51.8-1.11.3-1.3
Progressive ratio test 1 breakpoint1.11.31.5-1.01.2-1.2
Progressive ratio test 1 inactive lever presses0.20.30.5-0.70.4-0.3
Progressive ratio test 2 active lever presses0.20.20.4-0.30.5-0.6
Progressive ratio test 2 breakpoint0.30.30.6-0.40.6-0.7
Progressive ratio test 2 inactive lever presses0.00.00.0-0.0-0.10.0
Incentive Sensitization - Responses0.20.30.50.7-0.60.4
Incentive Sensitization - Breakpoint0.20.20.40.6-0.50.3
Sum of active levers in priming session hrs 5-61.91.72.01.4-1.21.3
Progressive ratio2.74.25.5-1.82.0-2.3
Food seeking constrained by brief footshock0.00.00.0-0.20.1-0.1
Seeking ratio, punishment vs. effort1.01.42.11.0-1.11.4
Retroperitoneal fat weight0.62.63.8-1.91.5-1.4
Reaction time number correct0.91.71.8-1.41.3-1.2
Reaction time mean minus median1.12.83.01.7-1.71.6
Reaction time mean minus median AUC1.02.52.81.7-1.61.5
Reaction time num false alarms1.42.02.3-1.51.3-1.4
Reaction time num false alarms AUC1.92.93.4-1.91.6-1.6
Reaction time trials correct on left0.91.71.8-1.41.3-1.2
Reaction time trials on left0.81.61.7-1.31.3-1.2
Reaction time mean2.13.44.42.1-1.81.6
Reaction time mean AUC1.42.23.01.7-1.51.2
Median of all reaction times1.72.43.41.9-1.51.2
Reaction time omissions1.11.62.01.4-1.31.1
Reaction time false alarm rate0.50.60.8-0.90.7-0.7
Reaction time premature initiation rate0.20.20.30.4-0.60.5
Reaction time premature initiations0.00.00.1-0.30.1-0.2
Std. dev. reaction times2.74.95.42.3-2.22.1
Reaction time trials completed0.81.61.7-1.31.3-1.2
Reaction time trials AUC0.81.51.6-1.31.3-1.2
Run reversals in cocaine runway, females0.50.50.7-0.60.7-0.9
Run reversals in cocaine runway, males0.40.40.5-0.60.7-0.6
Latency to leave start box in cocaine runway2.22.53.3-1.81.5-1.4
Latency to leave start box in cocaine runway, F0.20.20.5-0.70.3-0.2
Latency to leave start box in cocaine runway, M5.95.55.9-2.32.4-2.4
Std. dev. time between licks in bursts0.71.01.4-1.01.2-0.8
Total sessions with >9 infusions1.51.92.2-1.51.4-1.2
Short access day 1 total inactive lever presses0.30.40.7-0.90.7-0.4
Short access day 10 total inactive lever presses0.10.20.30.4-0.60.5
Short access day 1 total infusions1.31.72.0-1.41.4-1.1
Short access day 10 total infusions0.60.70.9-0.51.0-1.0
Short access total infusions1.21.51.8-1.11.4-1.2
Short access day 1 locomotion1.72.12.4-1.61.5-1.3
Short access day 10 total locomotion0.00.00.00.10.00.1
Short access total locomotion1.72.12.2-1.51.4-1.4
One hour access (0.3 mA shock)0.10.10.20.20.4-0.4
Compulsive drug intake0.10.10.10.3-0.20.3
One hour access (shock baseline)0.00.00.10.2-0.0-0.1
Social response proportion0.10.10.20.50.1-0.3
Social responses0.60.81.31.1-0.80.6
Social time4.25.86.92.6-2.32.3
Soleus weight0.72.22.6-1.61.6-1.2
Bone: stiffness0.40.60.8-0.90.7-0.8
Tibialis anterior weight2.48.39.2-3.02.9-2.7
Time to tail flick, vehicle, before self-admin0.00.00.00.2-0.20.1
Time to tail flick, vehicle, after self-admin0.10.20.30.5-0.40.3
Time to tail flick, test, before self-admin1.11.11.2-1.11.0-1.1
Time to tail flick, test, after self-admin3.53.74.3-2.11.8-1.9
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.0-0.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.50.3-0.3
Tibia length0.20.60.70.7-0.80.8
Ambulatory time before self-admin1.11.61.71.2-1.31.3
Ambulatory time after self-admin2.73.13.81.5-1.82.0
Bone: tissue strength0.20.20.3-0.40.3-0.5
Total heroin consumption0.00.00.00.10.2-0.1
Bone: trabecular number4.67.78.22.6-2.92.8
Bone: trabecular spacing3.44.54.8-2.02.1-2.2
Bone: trabecular thickness7.08.89.13.0-3.02.9
Bone: trabecular tissue density0.10.10.20.3-0.40.2
Water consumed over 24 hours0.10.20.3-0.10.4-0.6
Number of responses in last shaping day0.00.00.0-0.10.1-0.0