Echdc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Echdc2	0.12	0.07	1.8e-06	0.04	0.06	0.06	0.05	9.1e-06	5.6e-07	7.6e-07	5.8e-06
2	IC	alternative polyA	XM_063287395.1	0.09	0.07	9.6e-03	0	0.01	0.03	-0	1.9e-01	1.3e-01	1.5e-02	4.3e-01
3	IC	gene expression	Echdc2	0.12	0.08	1.9e-04	0.06	0.03	0.04	0.05	1.3e-03	1.4e-02	6.2e-03	2.6e-03
4	pVTA	gene expression	Echdc2	0.04	0.03	2.6e-03	0.02	0.02	0	0.02	1.4e-02	8.8e-03	1.7e-01	1.1e-02
5	Adipose	mRNA stability	Echdc2	0.03	0.02	2.6e-03	0.01	0.01	0.01	0.01	1.4e-02	2.2e-02	5.2e-02	2.1e-02
6	Liver	mRNA stability	Echdc2	0.11	0.06	3.7e-13	0.08	0.08	0.07	0.07	7.5e-09	7.3e-09	2.4e-08	2.4e-08
7	Liver	isoform ratio	NM_001106675.1	0.03	0.02	2.0e-03	0.01	0.01	0	0.01	1.6e-02	3.5e-02	1.5e-01	4.7e-02
8	Brain	mRNA stability	Echdc2	0.02	0.02	4.8e-03	0.02	0.02	0.02	0.02	5.0e-03	3.2e-03	6.2e-03	5.1e-03
9	Liver	gene expression	Echdc2	0.25	0.11	0.0e+00	0.16	0.18	0.18	0.18	2.5e-17	7.8e-20	1.3e-19	9.7e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.6	1.1	2.4	0.2	0.8	1.5	1.0	-1.2	-1.1	-1.0	-1.1	-1.1
Area under the delay curve	0.1	0.1	0.6	-0.8	-0.3	-0.1	0.1	-0.2	0.0	-0.1	0.2	0.3
BMI with tail	1.2	4.0	6.5	1.3	-0.9	-1.9	-2.4	2.5	2.3	2.4	2.0	1.8
BMI without tail	0.6	1.8	2.9	0.7	-0.5	-1.2	-1.6	1.7	1.6	1.5	1.4	1.4
Body weight	0.7	3.2	4.7	1.0	-1.0	-2.2	-2.0	2.1	1.9	2.0	1.7	1.5
Weight adjusted by age	0.2	0.3	1.0	1.0	-0.1	-0.4	-0.5	0.5	0.4	0.6	0.2	0.1
Bone surface	0.2	0.3	0.7	-0.2	0.3	0.8	0.6	-0.6	-0.6	-0.7	-0.5	-0.5
Bone volume	0.0	0.1	0.4	0.2	-0.1	0.6	0.2	-0.3	-0.2	-0.2	-0.2	-0.2
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.1	0.4	0.2	-0.3	-0.2	-0.1	-0.3	-0.3
Number of licking bursts	0.2	0.3	1.6	1.3	0.4	0.6	-0.4	0.6	0.2	0.5	-0.1	-0.2
Context. condit. distance diff. score	0.6	0.7	1.2	0.6	1.1	0.8	0.7	-0.3	-0.9	-0.7	-1.0	-1.1
Locomotion velocity, session 1	3.4	3.7	4.9	0.7	1.9	2.2	1.9	-1.9	-2.1	-1.8	-2.2	-2.2
Locomotion distance, session 1	0.2	0.3	0.9	0.7	1.0	0.1	0.3	-0.3	-0.4	-0.2	-0.5	-0.6
Locomotion velocity, session 2	3.5	4.1	6.3	0.9	2.3	2.5	1.9	-1.8	-2.1	-1.7	-2.3	-2.3
Locomotion distance, session 2	0.6	0.8	1.3	-0.5	-0.9	-0.8	-0.9	0.6	1.0	0.8	1.1	1.1
Locomotion velocity, session 3	0.8	0.9	1.3	-0.0	0.7	1.2	1.0	-0.8	-1.1	-1.1	-1.1	-1.1
Locomotion distance, session 3	0.3	0.3	0.8	-0.7	-0.9	-0.6	-0.3	0.2	0.4	0.1	0.6	0.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.6	0.8	0.6	0.4	0.1	0.1	-0.3	0.0	-0.5	-0.6
Stereotopy head waving duration, day 3	0.8	1.0	2.0	1.4	1.4	1.1	0.6	-0.1	-0.8	-0.4	-1.1	-1.2
Locomotion velocity, session 7	0.2	0.2	1.3	-1.1	-0.0	0.4	0.2	-0.3	-0.1	-0.6	0.1	0.2
Locomotion distance, session 7	0.6	0.7	3.8	-1.9	-0.9	-0.4	-0.1	-0.3	0.4	-0.4	0.7	0.9
Stereotopy head waving bouts, day 7	1.9	2.1	3.1	0.3	1.6	1.7	1.5	-1.0	-1.6	-1.4	-1.7	-1.8
Stereotopy head waving duration, day 7	1.9	2.3	3.5	0.5	1.4	1.7	1.6	-1.1	-1.7	-1.5	-1.8	-1.9
Locomotion velocity, session 8	1.7	2.1	2.5	-0.0	1.4	1.6	1.5	-1.5	-1.6	-1.6	-1.6	-1.6
Locomotion distance, session 8	0.0	0.1	0.1	-0.0	0.4	0.3	0.2	-0.1	-0.2	-0.3	-0.2	-0.3
Degree of sensitization distance	0.1	0.1	0.2	-0.5	-0.1	-0.0	-0.2	0.1	0.3	0.1	0.4	0.4
Degree of sensitization stereotypy	1.0	1.1	1.7	-0.0	1.0	1.3	1.1	-0.7	-1.2	-1.1	-1.2	-1.2
Conditioned locomotion	0.4	0.4	2.3	1.5	0.8	0.6	-0.2	0.2	0.0	0.4	-0.3	-0.4
Cocaine response after cond. corrected	2.5	3.0	5.0	-0.6	-2.2	-1.9	-1.7	1.3	1.8	1.5	2.0	2.0
Cocaine response after cond. not corrected	2.9	3.5	5.5	-0.2	-2.4	-1.9	-1.9	1.7	2.0	1.8	2.0	2.0
Cocaine response before conditioning	0.1	0.1	0.6	0.8	0.1	0.0	-0.2	0.5	0.1	0.3	-0.0	-0.1
Saline control response	0.5	0.6	3.1	-1.8	-0.7	-0.4	-0.1	-0.3	0.4	-0.1	0.7	0.9
Bone: connectivity density	0.9	1.4	2.3	-0.5	0.7	1.5	1.3	-1.4	-1.3	-1.4	-1.1	-1.0
Bone: cortical apparent density	2.2	3.1	6.8	0.4	1.6	2.6	1.7	-1.6	-1.8	-1.7	-1.9	-1.8
Bone: cortical area	1.2	1.9	2.7	-0.1	-1.1	-1.6	-1.5	1.4	1.5	1.4	1.5	1.5
Bone: cortical porosity	0.9	1.0	4.0	2.0	1.2	0.9	0.3	0.1	-0.6	0.1	-1.0	-1.2
Bone: cortical porosity	1.2	1.3	2.6	1.6	1.4	1.2	0.7	-0.4	-1.0	-0.3	-1.3	-1.5
Bone: cortical thickness	2.2	3.7	5.3	0.7	-1.3	-2.2	-2.2	2.3	2.1	2.2	2.0	1.8
Bone: cortical thickness	1.5	1.7	2.9	1.2	-0.7	-1.3	-1.6	1.6	1.4	1.7	1.2	0.9
Bone: cortical tissue density	2.6	3.5	7.5	0.5	1.8	2.7	1.8	-1.6	-1.9	-1.7	-2.0	-1.9
Condit. Reinf. active minus inactive responses	0.5	0.6	1.0	0.4	-1.0	-0.6	-0.8	0.7	0.8	0.8	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.1	0.2	-1.0	-1.0	-0.9	0.8	0.9	0.9	0.9	0.8
Condit. Reinf. active responses	1.0	1.2	1.7	0.6	-1.1	-0.9	-1.3	1.2	1.3	1.3	1.1	1.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	-0.1	-0.0	-0.3	0.3	0.4	0.3	0.4	0.5
Incentive salience index mean	1.6	1.9	2.5	0.8	-1.5	-1.2	-1.6	1.5	1.5	1.6	1.3	1.2
Condit. Reinf. lever presses	1.5	2.1	2.9	0.9	-1.2	-1.4	-1.7	1.7	1.6	1.6	1.4	1.3
Condit. Reinf. active minus inactive responses	0.5	0.7	1.5	-1.2	-0.9	-0.3	-0.6	0.4	0.8	0.4	1.0	1.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.1	-1.0	-0.3	0.2	-0.2	0.1	0.3	0.0	0.5	0.7
Condit. Reinf. active responses	0.3	0.4	0.7	-0.5	-0.6	-0.2	-0.6	0.6	0.7	0.5	0.8	0.9
Condit. Reinf. inactive responses	0.3	0.4	0.6	0.6	-0.5	-0.3	-0.7	0.8	0.6	0.7	0.5	0.4
Condit. Reinf. lever presses	0.4	0.5	2.3	-1.5	-1.1	0.3	0.3	-0.4	-0.1	-0.6	0.3	0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.8	-0.7	-0.2	-0.5	0.4	0.7	0.3	0.8	0.9
Conditioned reinforcement - actives	2.0	3.4	5.2	-1.3	-2.3	-1.5	-1.8	1.4	2.0	1.7	2.2	2.2
Conditioned reinforcement - inactives	0.1	0.1	0.6	0.0	-0.8	-0.2	-0.3	0.3	0.2	0.3	0.2	0.1
Conditioned locomotion	0.7	0.9	1.4	-0.7	-0.8	-0.7	-1.0	0.6	1.1	1.0	1.2	1.2
Patch foraging indifference point 0 sec	0.3	0.5	0.9	-0.0	-0.1	-0.6	-0.9	0.8	0.9	0.8	0.9	0.9
Patch foraging indifference point AUC	0.2	0.3	0.7	-0.3	0.8	0.5	0.6	-0.4	-0.6	-0.6	-0.5	-0.4
Delay disc. indifference point, 0s delay	0.3	0.3	1.4	-1.2	-0.6	0.3	0.5	-0.5	-0.4	-0.6	-0.1	-0.0
Delay disc. indifference point, 16s delay	1.0	1.1	1.5	-0.1	-0.9	-1.2	-1.2	1.0	1.2	1.1	1.2	1.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.4	-0.5	0.2	0.2	-0.3	-0.2	-0.3	-0.1	-0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	-0.5	0.8	0.3	0.4	-0.5	-0.4	-0.4	-0.3	-0.2
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.1	0.0	0.2	0.1	0.3	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.6	0.1	-0.2	-0.0	-0.2	0.1	-0.0	0.2	0.3
Indifference point function ln k	0.3	0.5	0.8	0.3	-0.7	-0.6	-0.9	0.7	0.8	0.8	0.8	0.7
Indifference point function log k	0.3	0.5	0.8	0.3	-0.7	-0.6	-0.9	0.7	0.8	0.8	0.8	0.7
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	0.1	0.0	-0.5	-0.8	0.7	0.8	0.8	0.8	0.8
Patch foraging total patch changes 12 sec	0.8	1.0	1.4	-0.3	1.0	1.1	1.2	-1.0	-1.1	-1.2	-1.1	-0.9
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.1	-0.5	-0.5	-0.6	0.7	0.6	0.6	0.6	0.5
Patch foraging total patch changes 24 sec	0.6	1.1	1.7	0.4	-0.5	-1.0	-1.2	1.3	1.2	1.2	1.1	1.1
Patch foraging total patch changes 6 sec	0.3	0.4	0.7	-0.8	-0.6	-0.7	-0.4	0.5	0.6	0.3	0.7	0.8
Patch foraging time to switch 0 sec	0.8	1.7	2.4	0.1	0.7	1.5	1.4	-1.4	-1.5	-1.3	-1.5	-1.6
Patch foraging water rate 0 sec	1.2	2.6	3.8	0.7	-0.8	-1.5	-1.9	2.0	1.9	1.8	1.7	1.6
Patch foraging water rate 12 sec	2.0	4.2	6.3	0.2	-1.5	-2.5	-2.2	2.4	2.3	2.0	2.2	2.2
Patch foraging water rate 18 sec	0.1	0.1	0.7	0.6	0.9	0.3	0.0	0.0	-0.1	0.1	-0.2	-0.2
Patch foraging water rate 24 sec	0.1	0.1	0.8	0.9	0.3	0.2	-0.2	0.3	0.1	0.3	-0.1	-0.1
Patch foraging water rate 6 sec	1.0	1.5	2.2	0.5	-0.5	-0.9	-1.5	1.5	1.5	1.4	1.4	1.3
Seeking ratio, delayed vs. immediate footshock	2.4	3.0	4.2	-0.0	-2.0	-1.6	-1.8	1.8	1.8	1.8	1.8	1.7
Distance traveled before self-admin	0.2	0.2	0.7	0.8	0.2	-0.3	-0.4	0.7	0.3	0.5	0.2	0.1
Distance traveled after self-admin	0.8	1.0	1.9	0.8	0.4	-0.8	-1.1	1.4	1.1	1.2	0.9	0.9
Extensor digitorum longus weight	0.7	2.9	5.3	1.7	-0.4	-1.5	-2.1	2.1	1.8	2.3	1.4	1.1
Bone: elastic displacement	0.2	0.3	1.4	1.2	0.8	0.0	-0.1	0.4	-0.0	0.3	-0.3	-0.3
Bone: elastic work	0.2	0.2	0.3	0.5	0.6	-0.4	-0.4	0.5	0.4	0.4	0.3	0.3
Bone: endosteal estimation	0.0	0.1	0.2	-0.4	-0.2	0.1	0.4	-0.5	-0.3	-0.3	-0.2	-0.2
Bone: endosteal perimeter	0.2	0.4	1.8	-1.4	-0.6	0.1	0.6	-0.7	-0.4	-0.7	-0.1	0.0
Epididymis fat weight	0.1	0.2	1.2	-1.1	-0.1	-0.1	0.4	-0.7	-0.3	-0.5	-0.1	-0.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.3	0.2	-0.0	0.1	0.1	0.0	0.1	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.3	0.4	-0.1	-0.3	-0.0	0.3	0.3	0.3	0.4
Diff in mean of infusions in LGA sessions	0.2	0.3	1.2	-0.9	-1.1	-0.2	-0.2	0.1	0.3	0.1	0.5	0.6
Delay discount exponential model param	0.1	0.1	0.6	0.8	0.3	0.1	-0.1	0.2	-0.1	0.1	-0.2	-0.3
Extinction: sum of active levers before priming	0.3	0.3	2.1	1.5	0.4	0.0	-0.2	0.3	0.0	0.4	-0.3	-0.5
Active lever presses in extinction session 6	2.3	2.3	6.1	-0.5	-2.5	-1.4	-1.5	1.3	1.5	1.4	1.6	1.5
Bone: final force	0.0	0.1	0.3	-0.5	-0.2	-0.4	0.1	-0.1	-0.0	-0.2	0.1	0.1
Bone: final moment	0.1	0.1	0.4	-0.6	-0.4	-0.7	-0.1	0.0	0.2	-0.0	0.3	0.3
Food consumed during 24 hour testing period	1.1	1.5	3.4	-1.8	-1.5	-1.3	-0.7	0.4	1.0	0.3	1.3	1.5
Glucose	0.2	0.3	0.7	-0.8	-0.4	-0.7	-0.4	0.1	0.5	0.3	0.6	0.6
Heart weight	1.1	1.7	3.0	1.6	-0.6	-1.1	-1.6	1.6	1.4	1.7	1.0	0.8
Delay discount hyperbolic model param	0.1	0.1	0.5	0.7	0.2	0.0	-0.1	0.3	0.0	0.2	-0.1	-0.2
Intermittent access intake day 1-15 change	0.5	1.0	1.5	-0.5	-0.8	-1.1	-1.0	1.0	1.1	0.9	1.2	1.2
Intermittent access intake escalation	0.4	0.8	1.1	-0.1	-0.4	-1.0	-1.0	1.0	1.0	0.9	1.0	1.1
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.2	0.2	-0.5	-0.4	0.6	0.5	0.4	0.5	0.6
Intermitt. access day 1 inactive lever presses	0.5	1.8	2.3	-0.1	-1.5	-1.2	-1.5	1.3	1.5	1.4	1.5	1.4
Intermitt. access day 15 inactive lever presses	0.2	0.4	1.0	0.7	-0.0	-0.3	-0.9	0.6	0.8	1.0	0.6	0.5
Intermitt. access escalation Index	0.1	0.2	0.8	0.9	0.9	-0.2	0.1	0.0	-0.1	-0.1	-0.3	-0.3
Intermittent access day 1 total infusions	0.1	0.2	0.4	0.6	0.5	0.6	0.2	-0.2	-0.4	-0.1	-0.5	-0.6
Intermittent access day 15 total infusions	0.2	0.3	0.4	0.5	0.1	-0.5	-0.6	0.7	0.5	0.7	0.4	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	0.3	0.5	-0.1	-0.2	0.3	0.2	0.2	0.1	0.0
Intermittent access total infusions	0.1	0.1	0.4	0.6	0.6	0.3	0.0	-0.0	-0.1	0.1	-0.2	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.0	0.3	0.1	-0.3	-0.2	0.0	-0.3	-0.4
Intermittent access day 15 total locomotion	0.1	0.3	0.5	-0.7	-0.7	-0.3	-0.4	0.1	0.5	0.4	0.6	0.6
Intermittent access total locomotion	0.1	0.1	0.3	0.5	0.5	0.1	-0.1	0.0	-0.0	0.2	-0.1	-0.2
Intermittent access standard deviation	1.5	3.1	4.4	0.1	-2.1	-1.9	-1.9	1.9	1.9	1.8	1.9	1.7
Left kidney weight	5.0	23.2	30.2	1.3	-3.8	-5.5	-5.4	5.4	5.3	5.3	5.0	4.8
Right kidney weight	2.9	13.2	18.1	1.4	-2.4	-4.2	-4.1	4.1	4.1	4.0	3.7	3.5
Cocaine induced anxiety	0.5	0.7	2.1	1.5	1.1	-0.6	-0.8	0.8	0.7	0.8	0.4	0.3
Post-drug Anxiety	1.0	1.0	3.9	2.0	0.9	-0.8	-1.0	1.0	0.8	1.0	0.4	0.2
Baseline Anxiety	0.3	0.3	1.9	0.2	-1.4	-0.4	-0.4	0.4	0.3	0.4	0.3	0.2
Tail length	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	-0.1	-0.1	-0.0	-0.1	-0.1
Length with tail	0.2	0.8	1.7	-0.0	-0.8	-1.3	-0.9	0.7	0.9	0.9	0.9	0.9
Length without tail	1.5	5.0	7.5	-0.4	-2.1	-2.7	-2.3	2.1	2.4	2.2	2.5	2.4
Times rat made contact with spout	0.6	0.7	1.4	-0.9	-1.2	-0.8	-0.6	0.2	0.8	0.5	1.0	1.1
Lifetime Intake	0.0	0.0	0.0	0.1	0.1	0.2	0.0	-0.1	-0.1	-0.0	-0.1	-0.2
Liver weight, left	0.1	0.1	0.7	-0.8	-0.1	-0.2	0.4	-0.3	-0.3	-0.5	-0.1	-0.0
Liver weight, right	0.1	0.2	0.7	-0.9	0.1	-0.2	0.5	-0.7	-0.4	-0.6	-0.2	-0.1
Locomotor activity	0.4	0.7	2.0	-1.4	-1.4	-0.5	-0.2	0.1	0.5	0.0	0.8	1.0
Locomotor testing distance	0.7	1.3	2.9	-1.5	-1.7	-0.9	-0.7	0.6	1.0	0.4	1.3	1.5
Locomotor testing rearing	0.7	1.4	4.5	-2.1	-1.8	-0.8	-0.5	0.2	0.8	0.2	1.2	1.4
Locomotion in novel chamber	3.9	4.9	8.5	-0.7	-2.9	-2.2	-2.2	2.1	2.3	2.0	2.4	2.4
Locomotion in novel chamber post-restriction	0.2	0.4	2.3	1.5	0.2	-0.5	-0.4	0.6	0.2	0.5	-0.1	-0.3
Fecal boli incidents, locomotor time 1	0.2	0.2	1.0	-1.0	-0.6	-0.3	-0.2	-0.0	0.3	0.1	0.5	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.4	0.3	0.6	0.6	-0.7	-0.6	-0.7	-0.5	-0.5
Time >=10cm from walls, locomotor time 1	1.6	1.7	3.0	1.1	1.7	1.3	1.2	-0.9	-1.3	-0.9	-1.5	-1.5
Bouts of movement, locomotor time 1	0.5	0.6	1.1	-0.7	-0.0	0.5	1.0	-1.0	-0.9	-0.9	-0.7	-0.6
Total resting periods, locomotor time 1	0.4	0.4	0.8	-0.4	0.2	0.5	0.8	-0.9	-0.7	-0.8	-0.6	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.6	-0.8	-0.3	-0.0	0.3	-0.5	-0.2	-0.3	-0.0	0.1
Distance moved, locomotor task time 1	0.4	0.6	1.8	1.1	1.3	0.6	0.4	-0.0	-0.5	-0.3	-0.8	-0.9
Vertical activity count, locomotor time 1	0.1	0.2	0.5	0.3	0.1	-0.3	-0.6	0.7	0.6	0.5	0.5	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	0.8	0.8	0.0	-0.1	0.2	-0.0	0.2	-0.2	-0.3
Bouts of movement, locomotor time 2	0.4	0.6	1.2	0.8	0.7	0.6	0.7	-0.6	-0.9	-0.5	-1.0	-1.1
Total resting periods, locomotor time 2	0.3	0.5	1.0	0.7	0.5	0.5	0.7	-0.7	-0.8	-0.5	-0.9	-1.0
Rest time, locomotor task time 2	0.1	0.1	0.6	-0.8	0.1	0.1	0.4	-0.6	-0.3	-0.3	-0.1	0.0
Distance moved, locomotor task time 2	0.5	0.6	1.2	0.9	0.0	-0.8	-0.9	1.1	0.8	0.8	0.6	0.4
Vertical activity count, locomotor time 2	1.2	1.6	2.2	0.0	-1.0	-1.3	-1.5	1.4	1.5	1.2	1.4	1.4
Light reinforcement 1	0.1	0.3	0.9	1.0	0.2	-0.6	-0.5	0.7	0.4	0.6	0.2	0.1
Light reinforcement 2	0.9	1.4	2.2	1.0	-0.4	-1.3	-1.4	1.5	1.3	1.5	1.1	1.0
Bone: marrow area	0.0	0.1	0.2	-0.4	-0.3	0.0	0.3	-0.4	-0.2	-0.2	-0.2	-0.1
Bone: maximum diameter	0.1	0.2	0.3	0.4	-0.3	-0.6	-0.5	0.6	0.4	0.5	0.3	0.3
Bone: maximum force	0.0	0.1	0.2	-0.5	-0.0	-0.5	-0.0	-0.1	0.1	-0.0	0.2	0.2
Bone: maximum moment	0.1	0.1	0.5	-0.5	-0.2	-0.7	-0.2	0.1	0.3	0.1	0.4	0.4
Mean time between licks in bursts	0.7	1.6	2.8	-1.7	0.2	1.4	1.5	-1.5	-1.2	-1.6	-0.9	-0.6
Mean num. licks in bursts	0.7	1.0	2.1	-1.3	-1.3	-1.4	-0.6	0.1	0.8	0.4	1.1	1.2
Cd content in liver	0.5	0.5	0.8	-0.5	0.4	0.6	0.9	-0.8	-0.8	-0.9	-0.7	-0.7
Co content in liver	0.1	0.1	0.4	-0.6	-0.0	-0.6	0.1	-0.3	-0.1	-0.2	0.0	0.1
Cu content in liver	0.7	0.8	5.0	-2.2	-0.8	0.1	0.4	-0.7	-0.1	-0.7	0.4	0.7
Fe content in liver	0.6	0.7	1.3	1.0	-0.2	-1.1	-0.8	1.0	0.8	0.9	0.6	0.5
K content in liver	0.9	0.8	4.1	-2.0	-1.3	-0.3	0.4	-0.7	-0.1	-0.7	0.3	0.6
Mg content in liver	2.0	2.1	3.7	-1.9	-1.8	-1.6	-0.9	0.7	1.3	0.6	1.6	1.8
Mn content in liver	0.2	0.2	0.4	0.1	0.0	0.4	0.6	-0.4	-0.6	-0.5	-0.6	-0.6
Na content in liver	0.3	0.3	0.7	-0.7	-0.3	0.4	0.7	-0.7	-0.6	-0.8	-0.4	-0.3
Rb content in liver	0.2	0.2	1.2	-1.1	-0.5	-0.4	0.0	-0.0	0.1	-0.2	0.3	0.4
Se content in liver	0.2	0.2	1.2	-1.1	-0.5	-0.1	0.3	-0.3	-0.1	-0.4	0.2	0.3
Sr content in liver	0.0	0.0	0.3	0.2	-0.5	0.1	0.0	0.0	-0.0	0.0	-0.1	-0.1
Zn content in liver	0.8	0.9	3.8	-2.0	-0.7	0.3	0.8	-1.1	-0.5	-1.1	-0.1	0.1
Bone: minimum diameter	0.8	1.4	2.4	-1.5	-1.5	-1.2	-0.8	0.5	1.1	0.7	1.4	1.5
Time in familiar zone, hab. session 1	0.4	0.4	0.9	0.1	1.0	0.6	0.6	-0.5	-0.6	-0.6	-0.6	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.5	-0.7	-0.7	0.1	0.3	-0.2	-0.2	-0.3	-0.0	-0.0
Total zone transitions, hab. session 1	0.3	0.4	1.2	1.1	0.9	0.6	0.3	-0.2	-0.5	-0.1	-0.7	-0.8
Total locomotion distance, hab. session 1	0.4	0.5	2.6	1.6	0.7	-0.3	-0.5	0.6	0.3	0.7	-0.0	-0.2
Locomotion velocity, hab. session 1	0.3	0.4	2.0	1.4	0.8	-0.3	-0.4	0.4	0.2	0.5	-0.1	-0.3
Time in familiar zone, hab. session 2	0.6	0.6	3.1	-1.8	-0.3	0.2	0.6	-0.9	-0.3	-0.8	0.0	0.3
Time in novel zone, hab. session 2	0.2	0.2	1.0	1.0	0.2	-0.2	-0.2	0.4	0.0	0.3	-0.2	-0.3
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.5	-0.5	-0.4	-0.2	-0.2	0.2	0.0	0.3	0.4
Total locomotion distance, hab. session 2	0.4	0.5	1.0	0.2	-0.4	-1.0	-0.8	0.5	0.8	0.7	0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.5	1.0	0.4	-0.4	-1.0	-0.9	0.6	0.8	0.8	0.7	0.7
Novel to familiar place preference ratio	1.6	1.7	2.8	-1.2	-1.4	-1.5	-1.1	1.1	1.3	1.0	1.6	1.7
Novelty place preference	0.8	0.9	1.5	-1.0	-0.9	-1.0	-0.8	0.8	0.9	0.7	1.1	1.2
Time in novel zone, NPP test	0.7	0.8	1.2	-1.0	-1.0	-0.8	-0.6	0.6	0.8	0.6	1.0	1.1
Total zone transitions, NPP test	0.6	0.9	1.6	1.1	-0.4	-1.0	-1.2	0.8	1.0	1.3	0.8	0.6
Total locomotion distance, NPP test	0.8	1.1	1.7	1.0	-0.5	-1.2	-1.3	1.0	1.1	1.3	0.9	0.8
Locomotion velocity, NPP test	1.2	1.7	2.7	1.2	-0.6	-1.5	-1.6	1.4	1.5	1.6	1.2	1.1
Intraocular pressure	0.3	0.4	0.7	-0.4	-0.6	-0.8	-0.6	0.5	0.7	0.5	0.7	0.7
Delta distance traveled before/after self-admin	1.2	1.3	1.8	-0.1	-0.7	-1.2	-1.2	1.3	1.3	1.2	1.3	1.4
Delta ambulatory time before/after self-admin	0.8	1.0	1.4	-0.1	-0.8	-0.9	-1.1	1.0	1.1	1.0	1.1	1.2
Parametrial fat weight	0.1	0.2	1.1	0.4	1.1	0.0	0.1	0.0	-0.1	-0.2	-0.2	-0.1
Pavlov. Cond. lever latency	1.4	1.8	3.0	-1.4	0.8	1.3	1.5	-1.7	-1.4	-1.6	-1.1	-0.9
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.2	0.0	0.4	0.6	-0.5	-0.5	-0.6	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	0.5	-0.1	0.3	-0.1	0.1	-0.0	0.2	-0.1	-0.1
Pavlov. Cond. index score	0.3	0.3	0.5	0.7	-0.6	-0.6	-0.6	0.7	0.6	0.6	0.4	0.4
Pavlov. Cond. latency score	0.3	0.4	0.7	0.8	-0.6	-0.6	-0.7	0.9	0.6	0.7	0.5	0.4
Pavlov. Cond. lever contacts	1.0	1.2	2.0	1.3	-0.6	-1.0	-1.3	1.4	1.1	1.3	0.9	0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.0	0.3	-0.3	-0.6	0.5	0.6	0.6	0.6	0.6
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.3	-1.0	-1.2	-1.1	-1.0	0.8	1.2	0.8	1.4	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.6	-0.7	-0.8	-0.8	0.8	0.7	0.8	0.6	0.6
Pavlov. Cond. response bias	0.1	0.1	0.6	0.8	-0.3	-0.2	-0.2	0.3	0.2	0.3	0.0	-0.0
Pavlov. Cond. lever latency	0.8	1.1	4.4	2.1	1.7	0.2	0.2	0.1	-0.5	0.2	-1.0	-1.2
Pavlov. Cond. magazine entry latency	1.3	1.5	7.8	-2.8	-1.1	0.1	0.9	-1.3	-0.5	-1.3	0.1	0.4
Pavlov. Cond. change in total contacts	0.7	1.2	5.9	-2.4	-1.6	0.0	0.1	-0.5	0.3	-0.5	0.8	1.1
Pavlov. Cond. index score	1.2	1.6	8.7	-3.0	-1.7	-0.1	0.5	-0.9	-0.0	-0.9	0.6	1.0
Pavlov. Cond. latency score	1.2	1.5	8.1	-2.8	-1.6	-0.1	0.4	-0.8	0.0	-0.9	0.6	1.0
Pavlov. Cond. lever contacts	0.6	0.9	3.5	-1.9	-1.5	-0.1	-0.1	-0.2	0.4	-0.3	0.8	1.0
Pavlov. Cond. magazine entry number	1.7	2.1	8.5	2.9	0.7	-0.7	-1.4	1.8	1.0	1.8	0.4	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.8	2.6	1.6	1.3	1.0	0.2	0.0	-0.5	0.1	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	10.0	-3.2	-1.7	-0.2	0.5	-1.0	-0.0	-1.0	0.6	1.0
Pavlov. Cond. response bias	0.8	1.1	5.8	-2.4	-1.3	0.3	0.4	-0.8	-0.1	-0.9	0.4	0.7
Time in closed arm before self-admin	0.6	0.7	2.2	0.3	1.5	0.8	0.8	-0.7	-0.8	-0.7	-0.9	-0.9
Time in closed arm after self-admin	0.3	0.4	1.2	0.5	1.1	0.6	0.4	-0.4	-0.5	-0.4	-0.6	-0.6
Time in open arm before self-admin	0.4	0.5	2.4	-0.9	-1.5	-0.3	-0.2	0.4	0.3	0.1	0.5	0.6
Time in open arm after self-admin	0.8	0.8	1.3	-0.5	-0.8	-0.8	-0.9	0.8	1.0	0.9	1.1	1.2
Bone: periosteal estimation	0.3	0.6	0.9	0.0	-0.8	-1.0	-0.8	0.8	0.8	0.8	0.8	0.8
Bone: periosteal perimeter	0.1	0.2	0.6	-0.6	-0.7	-0.6	-0.3	0.3	0.4	0.3	0.5	0.6
Bone: post-yield work	0.0	0.1	0.2	-0.3	-0.4	-0.2	0.2	-0.4	-0.2	-0.2	-0.1	-0.1
Progressive ratio test 1 active lever presses	0.4	0.5	0.9	0.5	-0.7	-0.6	-0.9	0.7	0.8	1.0	0.7	0.5
Progressive ratio test 1 breakpoint	0.4	0.5	1.0	0.6	-0.6	-0.6	-0.9	0.7	0.8	1.0	0.7	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.6	0.5	-0.6	-0.1	-0.7	0.5	0.6	0.7	0.4	0.3
Progressive ratio test 2 active lever presses	0.2	0.3	0.7	0.5	-0.1	-0.1	-0.6	0.6	0.6	0.8	0.4	0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.7	0.7	0.1	-0.1	-0.6	0.6	0.5	0.8	0.4	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	-0.0	0.2	0.3	0.2	0.1
Incentive Sensitization - Responses	0.0	0.0	0.1	0.0	0.3	0.3	0.0	0.0	-0.0	0.1	-0.1	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	0.2	0.2	-0.0	0.1	0.0	0.1	0.0	0.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	1.1	1.1	-0.3	0.0	-0.3	0.4	0.2	0.5	-0.0	-0.2
Progressive ratio	0.3	0.5	1.0	-0.1	-0.9	-1.0	-0.6	0.6	0.7	0.6	0.7	0.7
Food seeking constrained by brief footshock	2.7	3.3	4.6	-0.3	1.8	1.5	2.0	-2.1	-2.1	-1.9	-2.0	-1.9
Seeking ratio, punishment vs. effort	2.7	4.0	4.9	-0.1	2.0	2.1	2.2	-2.1	-2.2	-2.1	-2.2	-2.1
Retroperitoneal fat weight	0.1	0.4	1.2	-0.2	1.1	0.3	0.6	-0.5	-0.6	-0.6	-0.6	-0.5
Reaction time number correct	0.2	0.4	1.6	1.1	1.3	0.7	0.1	0.0	-0.2	0.1	-0.5	-0.6
Reaction time mean minus median	0.5	1.3	6.2	-2.5	-1.9	-0.2	0.2	-0.8	0.1	-0.5	0.6	0.8
Reaction time mean minus median AUC	0.3	0.9	4.0	-2.0	-1.7	0.0	0.3	-0.7	-0.0	-0.5	0.4	0.6
Reaction time num false alarms	1.6	2.2	4.7	-1.1	-2.2	-1.7	-1.2	1.1	1.4	1.0	1.6	1.7
Reaction time num false alarms AUC	2.4	3.7	7.4	-1.2	-2.7	-2.1	-1.6	1.5	1.9	1.4	2.1	2.2
Reaction time trials correct on left	0.2	0.4	1.6	1.1	1.3	0.7	0.1	0.0	-0.2	0.1	-0.5	-0.6
Reaction time trials on left	0.2	0.4	1.4	0.9	1.2	0.7	0.1	0.0	-0.2	0.1	-0.4	-0.5
Reaction time mean	0.5	0.8	4.4	-2.1	-1.0	0.5	0.5	-0.9	-0.2	-0.7	0.2	0.4
Reaction time mean AUC	0.5	0.8	3.4	-1.8	-0.7	0.7	0.7	-1.0	-0.5	-0.8	-0.1	0.0
Median of all reaction times	0.4	0.6	2.4	-1.6	-0.5	0.8	0.6	-0.8	-0.4	-0.7	-0.1	0.0
Reaction time omissions	1.0	1.5	6.4	-2.5	-1.8	-0.5	-0.3	-0.2	0.6	0.1	1.1	1.3
Reaction time false alarm rate	3.1	4.3	10.1	-1.5	-3.2	-2.4	-1.6	1.5	1.9	1.3	2.2	2.4
Reaction time premature initiation rate	0.2	0.2	1.2	-1.1	0.2	0.1	0.4	-0.5	-0.2	-0.4	0.0	0.2
Reaction time premature initiations	0.2	0.3	1.2	-0.5	1.1	0.6	0.5	-0.6	-0.4	-0.4	-0.3	-0.2
Std. dev. reaction times	0.8	1.4	6.8	-2.6	-1.9	-0.3	0.1	-0.6	0.3	-0.3	0.8	1.0
Reaction time trials completed	0.2	0.4	1.4	0.9	1.2	0.7	0.1	0.0	-0.2	0.1	-0.4	-0.5
Reaction time trials AUC	0.1	0.3	1.1	0.9	1.1	0.5	-0.1	0.2	0.0	0.3	-0.2	-0.3
Run reversals in cocaine runway, females	0.2	0.2	0.8	-0.9	-0.7	0.2	0.4	-0.5	-0.3	-0.4	-0.1	0.0
Run reversals in cocaine runway, males	3.1	3.1	8.2	-0.8	-2.9	-1.7	-1.6	1.4	1.7	1.4	1.8	1.8
Latency to leave start box in cocaine runway	0.7	0.8	1.4	1.2	-1.1	-0.7	-1.0	1.0	0.8	1.0	0.6	0.4
Latency to leave start box in cocaine runway, F	1.3	1.4	2.7	1.6	-1.3	-0.8	-1.3	1.4	1.1	1.4	0.8	0.5
Latency to leave start box in cocaine runway, M	0.1	0.1	0.8	-0.9	-0.4	0.1	0.2	-0.3	-0.1	-0.2	0.1	0.2
Std. dev. time between licks in bursts	1.8	2.4	3.7	-1.0	0.8	1.8	1.8	-1.7	-1.7	-1.9	-1.5	-1.4
Total sessions with >9 infusions	0.1	0.2	0.9	-0.6	-0.9	0.2	0.1	-0.3	-0.1	-0.1	0.0	0.0
Short access day 1 total inactive lever presses	1.3	1.7	2.6	0.7	-1.1	-1.3	-1.5	1.6	1.4	1.5	1.3	1.1
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.0	-0.0	-0.5	-0.5	0.5	0.6	0.5	0.6	0.6
Short access day 1 total infusions	0.0	0.0	0.2	0.2	-0.5	0.1	-0.1	0.1	0.0	0.1	-0.0	-0.1
Short access day 10 total infusions	0.2	0.2	1.2	1.1	0.4	0.0	-0.3	0.2	0.1	0.4	-0.1	-0.3
Short access total infusions	0.0	0.1	0.1	-0.1	-0.3	0.2	0.2	-0.3	-0.2	-0.2	-0.2	-0.3
Short access day 1 locomotion	1.0	1.2	1.9	-0.6	-1.4	-1.0	-1.1	0.8	1.2	1.1	1.2	1.2
Short access day 10 total locomotion	0.3	0.6	0.9	0.3	-0.7	-1.0	-0.9	0.8	0.9	0.9	0.8	0.7
Short access total locomotion	0.0	0.1	0.1	0.1	0.0	0.3	0.2	-0.3	-0.3	-0.2	-0.3	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.4	-0.5	-0.0	0.6	0.4	-0.5	-0.3	-0.3	-0.3	-0.2
Compulsive drug intake	0.7	0.9	1.1	0.4	1.1	0.8	0.9	-1.0	-1.0	-0.9	-1.1	-1.1
One hour access (shock baseline)	0.7	1.1	1.4	-0.2	-1.1	-0.9	-1.2	1.1	1.2	1.2	1.2	1.2
Social response proportion	0.2	0.3	0.7	-0.8	-0.0	0.6	0.5	-0.9	-0.4	-0.5	-0.2	-0.1
Social responses	1.2	1.6	2.6	-1.1	0.7	1.5	1.4	-1.6	-1.3	-1.5	-1.1	-0.9
Social time	0.2	0.2	0.5	-0.7	-0.4	-0.5	-0.3	0.1	0.4	0.2	0.6	0.6
Soleus weight	2.2	6.6	9.6	0.9	-1.3	-2.5	-3.1	2.9	3.0	3.1	2.8	2.5
Bone: stiffness	0.0	0.0	0.2	-0.4	-0.3	0.1	0.1	-0.2	-0.1	-0.1	0.0	0.0
Tibialis anterior weight	2.6	8.9	15.1	3.1	-0.9	-2.7	-3.6	3.7	3.2	3.9	2.5	2.0
Time to tail flick, vehicle, before self-admin	1.8	1.9	2.8	1.2	-1.3	-1.5	-1.5	1.7	1.4	1.5	1.1	0.9
Time to tail flick, vehicle, after self-admin	0.5	0.7	1.7	1.3	-0.5	-1.1	-0.9	0.9	0.7	0.9	0.5	0.3
Time to tail flick, test, before self-admin	2.5	2.6	8.0	2.8	1.1	-1.4	-1.6	1.9	1.4	1.8	0.8	0.5
Time to tail flick, test, after self-admin	0.9	0.9	1.7	1.3	-0.0	-1.0	-1.1	1.2	1.0	1.1	0.7	0.6
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.2	0.4	-0.1	-0.2	-0.2	0.2	0.1	0.1	0.0	-0.0
Delta time to tail flick, test, before/after SA	0.5	0.5	2.0	-1.4	-1.4	0.2	0.3	-0.4	-0.2	-0.4	0.1	0.2
Tibia length	0.2	0.6	1.5	0.3	-1.2	-0.7	-0.7	0.6	0.8	0.7	0.8	0.8
Ambulatory time before self-admin	0.1	0.1	0.3	0.5	-0.0	-0.2	-0.2	0.5	0.2	0.3	0.1	0.0
Ambulatory time after self-admin	0.5	0.6	1.1	0.7	-0.1	-0.6	-0.9	1.1	0.8	0.9	0.7	0.7
Bone: tissue strength	0.5	0.5	1.4	-1.2	0.2	0.2	0.9	-1.0	-0.7	-1.0	-0.4	-0.2
Total heroin consumption	0.3	0.4	0.8	-0.1	-0.6	0.9	0.6	-0.8	-0.6	-0.6	-0.6	-0.6
Bone: trabecular number	0.8	1.3	3.1	-0.3	1.1	1.8	1.1	-1.2	-1.1	-1.2	-1.0	-0.9
Bone: trabecular spacing	1.1	1.4	2.4	0.9	-0.9	-1.5	-1.4	1.4	1.2	1.4	1.0	0.8
Bone: trabecular thickness	0.5	0.7	1.7	-0.8	0.2	1.0	0.9	-1.3	-0.7	-0.9	-0.5	-0.3
Bone: trabecular tissue density	0.3	0.5	0.9	0.7	0.8	0.9	0.6	-0.5	-0.7	-0.4	-0.8	-0.8
Water consumed over 24 hours	0.9	1.2	1.9	-0.7	-1.3	-1.0	-1.1	0.8	1.2	0.9	1.3	1.4
Number of responses in last shaping day	2.2	2.4	3.2	-0.0	-1.3	-1.6	-1.7	1.6	1.8	1.7	1.8	1.7