Hub : Genes

Ebf4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ebf4 0.14 0.07 0.0e+00 0.16 0.17 0.18 0.18 1.5e-16 9.6e-19 6.2e-19 5.0e-19
2 BLA gene expression Ebf4 0.3 0.19 3.1e-10 0.13 0.05 0.14 0.14 3.3e-07 1.7e-03 1.3e-07 1.1e-07
3 Brain gene expression Ebf4 0.21 0.14 0.0e+00 0.17 0.18 0.18 0.18 8.3e-16 2.1e-16 2.3e-16 2.7e-16
4 NAcc gene expression Ebf4 0.07 0.06 2.1e-07 0.04 0.05 0.05 0.05 1.8e-07 7.4e-08 2.9e-08 1.9e-08
5 PL mRNA stability Ebf4 0.12 0.07 5.6e-17 0.14 0.16 0.15 0.15 8.4e-15 1.2e-16 4.0e-16 1.2e-15
6 IL mRNA stability Ebf4 0.48 0.24 8.3e-05 0.16 0.14 0.13 0.15 1.3e-04 3.7e-04 5.6e-04 2.2e-04
7 BLA mRNA stability Ebf4 0.07 0.06 9.9e-03 0.01 0 0.01 0.01 7.3e-02 2.5e-01 5.0e-02 4.9e-02
8 Brain mRNA stability Ebf4 0.2 0.12 0.0e+00 0.18 0.19 0.19 0.19 2.2e-16 1.6e-17 1.3e-17 7.1e-18
9 IC gene expression Ebf4 0.21 0.13 2.9e-07 0.12 0.01 0.11 0.07 9.1e-06 1.3e-01 2.9e-05 4.7e-04
10 Liver gene expression Ebf4 0.48 0.12 0.0e+00 0.44 0.44 0.44 0.44 1.6e-53 1.8e-53 1.0e-52 9.1e-53
11 Liver alternative TSS XM_063284541.1 0.03 0.02 1.0e-03 0.01 0.01 0.01 0.01 8.5e-03 1.4e-02 1.9e-02 2.5e-02
12 Liver alternative TSS XM_063284541.1 0.04 0.03 9.2e-06 0.03 0.03 0.03 0.02 3.8e-04 4.2e-04 5.0e-04 1.3e-03
13 OFC gene expression Ebf4 0.16 0.11 1.6e-03 0.11 0.13 0.09 0.12 1.6e-03 6.9e-04 3.7e-03 1.0e-03
14 pVTA gene expression Ebf4 0.04 0.03 1.8e-03 0.01 0.01 0.01 0.01 3.5e-02 8.9e-02 5.3e-02 5.1e-02
15 Liver mRNA stability Ebf4 0.03 0.02 5.1e-04 0.01 0.02 0 0.01 8.7e-03 5.8e-03 1.1e-01 2.4e-02
16 OFC mRNA stability Ebf4 0.18 0.13 1.4e-03 0.1 0.11 0.11 0.09 2.1e-03 1.4e-03 1.7e-03 3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.50.82.41.01.00.91.10.91.51.50.70.6-0.60.70.60.61.10.40.3
Area under the delay curve0.40.51.0-0.8-0.9-0.7-0.9-0.7-1.0-1.0-0.4-0.30.6-0.6-0.4-0.5-0.8-0.4-0.3
BMI with tail0.10.51.00.60.60.70.40.70.20.30.91.0-0.81.00.60.70.60.80.8
BMI without tail2.16.38.42.42.32.62.22.71.21.32.82.7-2.82.62.72.82.62.92.9
Body weight3.214.117.33.73.63.93.73.92.62.84.24.0-4.13.53.94.03.84.03.9
Weight adjusted by age2.74.15.81.52.42.22.42.22.32.31.91.7-1.91.82.12.01.61.91.8
Bone surface0.71.32.71.21.31.21.41.11.71.61.01.0-0.90.71.00.91.20.80.7
Bone volume0.71.32.61.21.31.21.41.11.61.61.01.1-0.90.80.90.91.10.80.7
Breakpoint value in progressive ratio session2.12.53.41.71.51.71.51.71.21.21.51.2-1.91.51.81.81.61.81.8
Number of licking bursts0.30.41.8-0.8-0.8-0.6-0.6-0.5-1.4-1.2-0.3-0.40.3-0.7-0.4-0.3-0.4-0.2-0.1
Context. condit. distance diff. score0.20.21.50.40.50.30.50.21.21.20.20.20.00.0-0.0-0.00.0-0.2-0.3
Locomotion velocity, session 10.30.41.20.50.70.60.60.61.00.50.40.3-0.51.10.50.50.20.40.4
Locomotion distance, session 10.60.73.80.91.10.80.90.72.01.50.40.4-0.30.80.30.30.50.1-0.1
Locomotion velocity, session 20.10.10.2-0.1-0.1-0.3-0.2-0.30.30.1-0.4-0.50.3-0.2-0.4-0.3-0.3-0.4-0.4
Locomotion distance, session 21.72.35.71.81.81.61.71.52.42.01.31.3-1.21.21.11.21.61.00.8
Locomotion velocity, session 31.21.31.91.21.11.21.31.20.70.81.41.4-1.30.71.21.21.11.21.2
Locomotion distance, session 36.26.88.32.62.62.72.62.71.92.12.92.8-2.72.22.72.72.82.72.6
Stereotopy head waving bouts, day 30.91.12.1-0.5-0.5-0.9-0.6-1.00.60.3-1.3-1.31.1-1.5-1.1-1.2-1.2-1.3-1.4
Stereotopy head waving duration, day 30.81.01.8-0.8-0.7-0.9-0.7-1.00.0-0.3-1.2-1.21.0-1.3-1.0-1.1-1.2-1.1-1.1
Locomotion velocity, session 70.80.91.20.91.11.01.01.01.11.01.01.1-0.90.30.90.90.70.90.8
Locomotion distance, session 70.91.13.31.11.31.11.21.11.81.60.80.9-0.80.50.80.81.10.70.6
Stereotopy head waving bouts, day 70.30.30.70.50.50.60.50.60.00.10.60.5-0.70.30.80.70.50.80.8
Stereotopy head waving duration, day 70.10.10.20.20.20.20.20.3-0.1-0.10.30.2-0.40.00.40.40.20.40.5
Locomotion velocity, session 80.70.83.61.01.10.91.00.81.91.60.60.7-0.40.50.50.40.50.30.1
Locomotion distance, session 82.84.112.12.22.52.12.31.93.53.31.71.8-1.31.41.31.31.61.00.8
Degree of sensitization distance1.81.82.7-1.3-1.0-1.3-1.2-1.3-0.1-0.5-1.6-1.61.6-1.5-1.4-1.5-1.4-1.5-1.6
Degree of sensitization stereotypy2.02.13.41.31.21.41.21.50.30.41.71.6-1.71.61.71.71.51.81.9
Conditioned locomotion4.34.96.02.42.42.32.52.32.22.32.32.4-2.22.32.22.11.62.01.9
Cocaine response after cond. corrected0.10.10.2-0.3-0.1-0.2-0.2-0.30.30.2-0.3-0.30.4-0.2-0.4-0.4-0.4-0.4-0.5
Cocaine response after cond. not corrected0.20.20.3-0.5-0.3-0.4-0.5-0.4-0.0-0.2-0.5-0.50.5-0.2-0.5-0.5-0.4-0.5-0.5
Cocaine response before conditioning0.20.20.5-0.4-0.4-0.5-0.6-0.4-0.5-0.7-0.6-0.70.3-0.3-0.3-0.3-0.1-0.2-0.2
Saline control response7.59.911.63.43.33.43.13.32.62.73.43.3-3.43.03.33.22.73.23.1
Bone: connectivity density0.20.31.30.60.50.50.70.41.11.10.30.3-0.20.40.20.20.70.1-0.0
Bone: cortical apparent density0.71.02.30.60.60.90.41.0-0.4-0.30.90.6-1.30.81.21.31.31.41.5
Bone: cortical area3.55.46.72.42.42.42.52.41.81.92.52.6-2.42.42.42.32.22.32.2
Bone: cortical porosity0.40.43.0-0.5-0.6-0.2-0.6-0.1-1.7-1.30.30.3-0.30.30.20.3-0.10.50.7
Bone: cortical porosity0.40.41.20.1-0.00.4-0.00.4-1.1-0.60.70.8-0.70.70.60.70.40.91.0
Bone: cortical thickness1.42.43.11.41.41.61.51.60.70.81.81.8-1.71.71.71.71.61.71.7
Bone: cortical thickness0.30.30.50.50.40.50.50.5-0.00.00.70.7-0.70.60.60.60.60.60.7
Bone: cortical tissue density0.60.81.90.50.50.80.30.9-0.5-0.40.70.4-1.10.61.01.21.21.31.4
Condit. Reinf. active minus inactive responses0.60.71.80.70.60.80.40.90.10.10.70.6-1.00.60.91.01.41.01.1
Condit. Reinf. active-inactive response ratio0.70.81.51.00.90.90.70.90.70.80.80.8-0.90.60.90.91.20.90.9
Condit. Reinf. active responses0.40.51.00.60.50.70.30.7-0.00.00.60.5-0.90.50.70.91.00.91.0
Condit. Reinf. inactive responses0.00.00.00.10.10.10.00.00.0-0.00.0-0.0-0.00.1-0.00.0-0.20.00.0
Incentive salience index mean0.30.40.80.60.50.60.20.60.10.10.50.4-0.70.40.70.70.90.80.8
Condit. Reinf. lever presses0.00.00.10.20.10.2-0.10.2-0.1-0.10.10.0-0.20.20.30.30.20.30.3
Condit. Reinf. active minus inactive responses2.63.44.32.12.11.91.81.91.91.81.61.4-1.91.91.91.82.01.81.7
Condit. Reinf. active-inactive response ratio2.42.83.61.81.81.71.71.81.61.51.51.3-1.81.71.71.71.91.61.6
Condit. Reinf. active responses4.25.97.02.62.62.52.52.52.52.32.22.0-2.52.62.52.42.62.32.2
Condit. Reinf. inactive responses0.81.01.91.01.11.01.11.01.41.30.90.9-0.91.20.90.80.80.80.7
Condit. Reinf. lever presses1.31.83.71.21.31.41.31.40.80.71.41.2-1.51.91.51.51.31.51.5
Condit. Reinf. lever reinforcers received3.34.65.82.32.42.22.22.22.32.11.91.7-2.22.42.12.12.22.01.9
Conditioned reinforcement - actives0.10.10.6-0.2-0.4-0.2-0.2-0.2-0.7-0.60.10.30.20.10.0-0.1-0.1-0.00.0
Conditioned reinforcement - inactives0.30.51.91.10.80.50.70.51.21.40.40.6-0.30.60.30.30.50.10.0
Conditioned locomotion0.10.20.7-0.5-0.5-0.4-0.5-0.4-0.8-0.7-0.1-0.00.2-0.1-0.2-0.2-0.8-0.1-0.1
Patch foraging indifference point 0 sec0.30.52.61.20.80.60.70.51.51.60.1-0.1-0.40.50.40.2-0.10.1-0.1
Patch foraging indifference point AUC0.71.01.51.00.91.11.01.10.40.81.00.9-1.10.91.11.11.21.11.1
Delay disc. indifference point, 0s delay2.73.04.6-2.0-1.8-1.7-1.8-1.7-1.8-2.0-1.6-1.61.7-1.5-1.5-1.6-2.1-1.6-1.5
Delay disc. indifference point, 16s delay0.70.81.5-0.8-1.1-1.0-1.1-0.9-1.1-1.2-0.8-0.70.8-0.9-0.7-0.8-0.9-0.7-0.6
Delay disc. indifference point, 2s delay0.10.10.2-0.3-0.3-0.3-0.4-0.3-0.5-0.1-0.10.10.2-0.0-0.1-0.2-0.4-0.2-0.2
Delay disc. indifference point, 24s delay2.52.84.9-2.2-1.8-1.8-1.8-1.7-1.7-1.9-1.7-1.71.6-1.4-1.4-1.6-1.3-1.5-1.4
Delay disc. indifference point, 4s delay0.10.10.3-0.1-0.10.1-0.10.1-0.3-0.30.30.5-0.10.20.30.3-0.10.40.4
Delay disc. indifference point, 8s delay0.60.81.9-1.0-1.1-0.9-1.1-0.8-1.4-1.3-0.7-0.60.6-0.8-0.5-0.6-1.0-0.4-0.3
Indifference point function ln k0.10.20.70.30.60.40.40.40.80.60.10.1-0.30.30.30.30.30.20.1
Indifference point function log k0.10.20.70.30.60.40.40.40.80.60.10.1-0.30.30.30.30.30.20.1
Patch foraging total patch changes 0 sec0.30.62.91.30.90.70.80.61.51.70.20.1-0.50.60.50.3-0.00.20.0
Patch foraging total patch changes 12 sec0.40.61.01.00.80.80.80.80.51.00.70.6-0.90.60.80.70.40.70.7
Patch foraging total patch changes 18 sec0.30.40.8-0.5-0.5-0.5-0.4-0.6-0.00.1-0.7-0.70.8-0.7-0.6-0.8-0.9-0.9-0.9
Patch foraging total patch changes 24 sec0.71.22.8-0.5-0.9-1.0-0.7-1.1-0.1-0.0-1.2-1.11.1-0.9-1.2-1.3-1.7-1.4-1.5
Patch foraging total patch changes 6 sec0.91.43.81.81.41.11.31.11.81.90.70.6-0.91.10.90.80.80.60.5
Patch foraging time to switch 0 sec2.14.37.3-2.4-2.3-2.2-2.4-2.1-2.7-2.7-1.7-1.71.9-2.1-2.1-1.8-1.8-1.6-1.4
Patch foraging water rate 0 sec4.18.713.83.63.33.03.33.03.73.72.62.4-2.82.92.82.62.62.32.1
Patch foraging water rate 12 sec0.20.51.80.80.70.50.40.51.31.30.20.3-0.50.80.60.30.70.20.1
Patch foraging water rate 18 sec0.40.61.11.00.70.70.70.70.90.80.70.9-0.71.10.90.60.90.60.6
Patch foraging water rate 24 sec0.60.81.80.60.80.80.80.90.60.30.90.8-0.91.31.11.01.11.01.0
Patch foraging water rate 6 sec2.23.23.91.81.81.91.81.91.51.51.71.6-1.91.92.01.81.61.81.8
Seeking ratio, delayed vs. immediate footshock0.20.30.9-0.9-0.3-0.5-0.4-0.5-0.4-0.7-0.7-1.00.6-0.2-0.5-0.4-0.3-0.4-0.4
Distance traveled before self-admin4.55.98.32.82.62.62.72.52.72.92.52.5-2.32.22.22.31.72.12.0
Distance traveled after self-admin1.92.43.41.41.71.61.81.61.71.51.71.8-1.61.31.41.51.11.51.4
Extensor digitorum longus weight0.00.20.50.20.50.50.70.40.50.10.60.7-0.30.30.40.40.50.40.3
Bone: elastic displacement0.20.21.3-0.5-0.5-0.2-0.4-0.2-1.1-1.1-0.1-0.2-0.00.3-0.10.10.20.20.3
Bone: elastic work0.10.10.7-0.3-0.3-0.1-0.2-0.0-0.8-0.80.20.3-0.10.30.10.20.30.30.3
Bone: endosteal estimation0.81.72.31.51.41.31.41.31.41.51.41.5-1.21.11.21.11.01.00.9
Bone: endosteal perimeter2.86.07.62.72.72.62.82.52.62.72.52.6-2.32.42.32.22.02.12.0
Epididymis fat weight0.00.10.3-0.6-0.3-0.2-0.5-0.2-0.2-0.5-0.3-0.30.2-0.5-0.1-0.2-0.2-0.2-0.2
Delta time in closed arm before/after self-admin0.70.71.0-1.0-0.9-0.9-0.9-0.9-1.0-0.7-0.7-0.51.0-1.0-0.8-0.8-0.6-0.7-0.7
Delta time in open arm before/after self-admin1.51.44.71.31.41.21.51.12.22.01.11.3-0.70.90.70.60.80.40.2
Diff in mean of infusions in LGA sessions0.10.10.40.10.40.30.20.40.40.50.10.0-0.30.50.40.30.70.30.3
Delay discount exponential model param0.40.40.90.80.80.70.80.61.00.90.40.2-0.50.60.30.40.70.40.3
Extinction: sum of active levers before priming1.31.42.51.01.11.21.21.20.60.81.51.6-1.31.11.21.31.01.31.3
Active lever presses in extinction session 60.00.00.30.20.00.0-0.1-0.00.10.2-0.1-0.2-0.1-0.3-0.1-0.1-0.5-0.1-0.1
Bone: final force3.35.36.12.42.32.42.22.41.51.72.52.4-2.52.42.42.42.12.42.4
Bone: final moment2.64.25.22.12.02.12.02.11.41.52.22.3-2.22.12.12.11.92.12.1
Food consumed during 24 hour testing period0.60.91.6-0.7-0.8-1.0-0.8-1.0-0.5-0.2-0.9-0.71.0-1.0-1.1-1.1-1.2-1.1-1.1
Glucose0.20.30.90.50.50.50.40.50.60.70.60.9-0.40.70.40.30.20.30.2
Heart weight3.96.010.82.72.82.62.72.53.13.32.01.8-2.42.62.12.12.31.91.7
Delay discount hyperbolic model param0.30.40.80.70.80.70.80.60.90.80.40.2-0.50.60.30.40.80.40.3
Intermittent access intake day 1-15 change0.10.10.30.40.30.40.20.4-0.1-0.00.40.4-0.40.40.40.50.20.50.6
Intermittent access intake escalation0.10.20.40.30.20.40.20.4-0.2-0.10.40.5-0.40.50.40.50.30.60.6
Intermittent access intake escalation 20.10.10.30.10.00.20.30.2-0.3-0.10.40.6-0.20.40.30.30.20.40.4
Intermitt. access day 1 inactive lever presses0.20.61.91.40.90.70.80.71.21.30.50.6-0.60.80.50.50.40.40.4
Intermitt. access day 15 inactive lever presses0.10.31.10.60.30.00.2-0.11.01.1-0.3-0.20.4-0.0-0.4-0.4-0.6-0.5-0.7
Intermitt. access escalation Index0.10.20.70.50.40.40.40.40.50.40.40.6-0.3-0.00.20.30.80.30.2
Intermittent access day 1 total infusions0.00.00.3-0.1-0.20.0-0.1-0.0-0.5-0.40.30.30.0-0.20.10.0-0.10.10.1
Intermittent access day 15 total infusions0.00.10.20.40.10.20.10.2-0.00.00.20.3-0.10.20.30.20.10.20.2
Intermittent access terminal intake (last 3 days)0.10.10.30.50.20.30.20.30.30.20.30.3-0.10.30.30.20.20.20.2
Intermittent access total infusions0.00.00.10.40.10.20.10.20.10.00.30.3-0.10.10.20.20.20.20.2
Intermittent access day 1 locomotion0.10.10.2-0.2-0.3-0.3-0.3-0.3-0.2-0.1-0.3-0.30.4-0.4-0.2-0.3-0.3-0.3-0.3
Intermittent access day 15 total locomotion0.20.31.30.80.60.50.70.41.11.10.40.6-0.20.60.40.2-0.20.1-0.0
Intermittent access total locomotion0.20.30.60.50.50.60.60.50.50.50.60.8-0.40.40.50.40.10.40.4
Intermittent access standard deviation0.10.30.50.50.50.50.40.50.30.20.50.6-0.60.60.70.70.50.70.7
Left kidney weight0.10.63.21.10.80.70.90.51.81.70.30.3-0.40.40.20.10.0-0.0-0.2
Right kidney weight0.20.73.41.10.90.71.00.61.81.80.40.4-0.40.80.40.20.2-0.0-0.2
Cocaine induced anxiety3.85.47.2-1.9-2.2-2.4-2.3-2.4-1.6-1.6-2.6-2.72.4-2.2-2.6-2.5-2.5-2.5-2.5
Post-drug Anxiety3.23.44.7-1.7-1.7-1.9-2.0-1.9-1.2-1.5-2.1-2.21.8-2.0-2.0-1.9-1.7-1.9-1.9
Baseline Anxiety0.10.10.30.00.30.30.20.30.3-0.10.40.4-0.4-0.00.50.40.60.40.4
Tail length3.915.317.64.13.94.24.14.23.03.04.13.8-4.23.34.24.13.94.14.0
Length with tail5.825.028.25.15.15.35.35.34.14.25.35.0-5.34.45.35.25.05.15.0
Length without tail2.58.09.82.93.03.03.12.92.83.03.02.9-2.82.52.82.72.62.62.5
Times rat made contact with spout0.10.10.60.30.20.00.0-0.00.50.8-0.10.00.1-0.3-0.2-0.2-0.1-0.2-0.3
Lifetime Intake0.20.20.50.50.40.50.40.50.40.20.60.7-0.40.30.40.40.30.40.4
Liver weight, left0.91.52.41.31.31.31.31.31.31.41.21.0-1.31.61.21.10.91.11.0
Liver weight, right0.20.30.70.50.50.60.50.60.00.10.60.4-0.80.50.80.70.40.70.8
Locomotor activity0.20.20.80.40.20.40.30.40.10.10.30.3-0.80.90.60.50.70.60.6
Locomotor testing distance0.00.10.2-0.1-0.3-0.3-0.2-0.3-0.0-0.1-0.4-0.20.10.1-0.3-0.3-0.1-0.4-0.4
Locomotor testing rearing0.30.61.50.90.80.70.90.71.21.10.50.5-0.70.80.70.60.70.50.4
Locomotion in novel chamber0.00.10.4-0.1-0.1-0.1-0.1-0.0-0.2-0.5-0.1-0.2-0.20.60.20.10.30.10.2
Locomotion in novel chamber post-restriction0.50.91.50.90.90.90.70.90.70.90.80.7-1.11.21.01.01.01.01.0
Fecal boli incidents, locomotor time 10.00.00.1-0.2-0.0-0.0-0.10.0-0.2-0.10.20.3-0.0-0.40.00.10.10.10.1
Change in fecal boli incidents, locomotor task0.10.10.5-0.7-0.2-0.3-0.3-0.30.20.0-0.4-0.20.3-0.4-0.4-0.3-0.4-0.4-0.4
Time >=10cm from walls, locomotor time 10.10.10.3-0.20.10.10.10.1-0.3-0.20.40.60.00.10.40.20.10.30.3
Bouts of movement, locomotor time 12.22.54.6-1.4-1.8-1.6-1.7-1.6-2.0-2.1-1.5-1.61.4-1.7-1.5-1.4-1.4-1.3-1.2
Total resting periods, locomotor time 11.92.14.1-1.3-1.7-1.4-1.6-1.4-1.9-2.0-1.4-1.51.2-1.5-1.3-1.2-1.1-1.1-1.0
Rest time, locomotor task time 10.40.41.0-0.5-0.8-0.6-1.0-0.6-0.9-1.0-0.7-0.70.6-0.8-0.5-0.4-0.1-0.4-0.3
Distance moved, locomotor task time 10.10.10.40.30.20.10.40.10.40.60.40.50.00.1-0.1-0.0-0.2-0.1-0.1
Vertical activity count, locomotor time 10.10.31.60.60.50.40.70.40.91.30.50.7-0.30.40.30.20.00.10.0
Time >=10cm from walls, locomotor time 20.00.10.2-0.1-0.2-0.1-0.1-0.1-0.3-0.5-0.2-0.40.1-0.40.0-0.0-0.30.00.0
Bouts of movement, locomotor time 20.61.03.5-0.3-1.3-0.9-1.2-0.9-1.9-1.7-0.6-0.50.6-1.4-0.7-0.6-0.5-0.5-0.4
Total resting periods, locomotor time 20.61.03.9-0.4-1.3-0.9-1.3-0.9-2.0-1.8-0.6-0.50.6-1.3-0.7-0.6-0.3-0.4-0.3
Rest time, locomotor task time 20.50.62.6-0.5-1.0-0.8-1.1-0.7-1.6-1.2-0.7-0.80.3-0.2-0.3-0.40.1-0.3-0.1
Distance moved, locomotor task time 20.20.31.50.50.50.30.70.21.21.00.20.30.20.1-0.2-0.1-0.3-0.3-0.4
Vertical activity count, locomotor time 20.50.73.51.30.80.71.00.61.61.90.50.6-0.30.40.30.20.20.1-0.1
Light reinforcement 10.51.21.91.11.01.11.01.20.50.80.90.6-1.30.71.21.31.21.41.4
Light reinforcement 20.50.81.10.70.80.90.71.00.70.70.80.6-0.90.70.91.01.01.01.0
Bone: marrow area0.71.62.31.51.41.31.41.31.41.51.31.5-1.11.11.11.10.91.00.9
Bone: maximum diameter4.89.010.83.33.23.13.23.12.83.03.13.2-2.93.12.92.92.72.72.6
Bone: maximum force1.01.82.51.41.41.41.41.41.11.11.51.6-1.41.41.41.31.11.31.3
Bone: maximum moment0.50.91.71.01.01.01.01.00.80.81.21.3-1.00.91.00.90.70.90.9
Mean time between licks in bursts0.00.00.1-0.1-0.2-0.2-0.2-0.1-0.3-0.3-0.00.00.10.2-0.2-0.1-0.2-0.1-0.1
Mean num. licks in bursts0.40.63.00.90.90.60.70.51.71.60.30.4-0.20.50.30.20.30.0-0.1
Cd content in liver2.02.23.21.71.51.51.41.51.11.31.51.4-1.51.51.61.61.81.61.6
Co content in liver2.42.83.71.71.61.71.51.71.11.11.91.9-1.71.41.71.81.81.81.8
Cu content in liver3.64.34.82.12.22.22.02.22.02.12.12.1-2.12.12.12.02.22.01.9
Fe content in liver0.00.10.30.30.10.10.20.10.10.20.10.1-0.20.60.10.20.40.20.2
K content in liver0.50.50.90.50.70.80.60.80.60.70.70.7-0.70.80.70.70.90.60.6
Mg content in liver3.63.74.81.81.92.01.82.01.41.52.12.1-1.92.22.02.02.11.91.9
Mn content in liver2.83.13.91.81.91.91.81.91.61.71.61.4-1.91.61.81.82.01.71.7
Na content in liver0.30.30.6-0.6-0.4-0.5-0.3-0.6-0.2-0.4-0.5-0.50.6-0.6-0.8-0.7-0.4-0.7-0.7
Rb content in liver5.05.88.92.62.62.52.42.42.93.02.32.5-2.02.52.22.12.51.91.7
Se content in liver1.21.52.51.11.21.21.21.20.81.01.11.0-1.31.61.21.31.51.21.2
Sr content in liver0.50.41.21.10.60.60.80.60.30.50.70.7-0.50.70.50.70.50.70.7
Zn content in liver1.61.82.61.31.21.41.01.40.60.91.41.4-1.51.61.51.51.41.51.5
Bone: minimum diameter1.93.54.52.02.02.02.11.91.61.82.02.1-1.81.91.81.81.61.71.6
Time in familiar zone, hab. session 11.31.32.9-1.2-1.0-1.1-1.0-1.1-0.6-0.6-1.2-1.11.2-1.7-1.2-1.2-0.9-1.2-1.2
Time in novel zone, hab. session 10.60.61.40.90.80.80.80.80.90.90.70.7-0.71.20.70.70.50.60.6
Total zone transitions, hab. session 10.30.41.40.60.70.60.60.51.21.00.50.5-0.2-0.00.30.30.80.20.1
Total locomotion distance, hab. session 10.20.32.10.30.60.30.40.31.41.10.00.00.1-0.3-0.1-0.00.4-0.1-0.3
Locomotion velocity, hab. session 10.20.31.80.50.70.40.50.41.41.00.20.2-0.0-0.10.10.10.50.0-0.1
Time in familiar zone, hab. session 21.41.41.9-1.1-1.1-1.2-1.2-1.2-0.7-0.7-1.3-1.31.3-1.4-1.3-1.3-1.2-1.3-1.3
Time in novel zone, hab. session 21.41.52.21.11.11.21.21.20.70.81.31.3-1.31.51.31.31.11.31.3
Total zone transitions, hab. session 22.22.93.71.71.81.91.71.81.41.41.91.7-1.71.21.81.81.91.71.7
Total locomotion distance, hab. session 20.81.13.41.21.31.11.21.01.81.60.80.7-0.70.50.70.70.90.60.4
Locomotion velocity, hab. session 20.50.62.90.91.00.80.90.71.71.50.50.4-0.30.20.40.40.60.20.0
Novel to familiar place preference ratio0.10.10.3-0.1-0.2-0.2-0.0-0.30.30.2-0.3-0.20.4-0.1-0.4-0.5-0.5-0.5-0.6
Novelty place preference0.20.30.6-0.3-0.4-0.4-0.2-0.50.1-0.0-0.5-0.40.6-0.3-0.6-0.7-0.8-0.7-0.8
Time in novel zone, NPP test0.10.10.4-0.1-0.2-0.3-0.1-0.30.20.1-0.3-0.20.5-0.2-0.4-0.5-0.6-0.5-0.6
Total zone transitions, NPP test0.10.10.30.20.30.40.20.40.20.00.40.2-0.30.10.40.40.60.40.4
Total locomotion distance, NPP test0.30.52.70.70.90.60.80.61.61.20.30.2-0.20.40.20.30.50.1-0.0
Locomotion velocity, NPP test0.10.21.70.30.50.30.40.21.30.9-0.0-0.10.10.2-0.1-0.10.1-0.2-0.3
Intraocular pressure0.00.00.20.2-0.00.10.10.1-0.1-0.30.10.2-0.1-0.50.20.20.00.20.3
Delta distance traveled before/after self-admin0.10.10.4-0.20.20.30.30.30.0-0.20.40.3-0.40.30.40.40.60.50.5
Delta ambulatory time before/after self-admin0.60.71.8-1.3-1.0-0.8-0.9-0.8-1.1-1.3-0.7-0.80.7-0.7-0.6-0.7-0.5-0.6-0.5
Parametrial fat weight0.20.61.8-0.9-1.0-0.8-1.0-0.7-1.3-1.0-0.6-0.70.5-0.3-0.5-0.5-0.7-0.4-0.3
Pavlov. Cond. lever latency0.20.20.40.30.30.40.40.40.00.10.40.4-0.60.60.60.60.50.60.6
Pavlov. Cond. magazine entry latency0.20.20.60.40.50.50.40.50.40.40.40.3-0.40.40.40.50.80.50.4
Pavlov. Cond. change in total contacts0.10.10.20.30.30.30.30.30.30.40.30.3-0.10.10.20.20.40.20.2
Pavlov. Cond. index score0.00.00.1-0.00.0-0.0-0.1-0.00.00.1-0.0-0.10.1-0.3-0.1-0.10.1-0.1-0.1
Pavlov. Cond. latency score0.10.10.2-0.2-0.2-0.3-0.3-0.3-0.0-0.0-0.3-0.40.4-0.5-0.4-0.4-0.2-0.4-0.4
Pavlov. Cond. lever contacts0.00.00.10.10.10.0-0.00.00.30.30.10.00.2-0.3-0.1-0.1-0.1-0.1-0.2
Pavlov. Cond. magazine entry number0.40.50.9-0.5-0.5-0.7-0.4-0.7-0.0-0.0-0.7-0.60.8-0.6-0.8-0.8-1.0-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.20.70.60.60.40.50.40.80.60.30.2-0.40.40.30.30.40.30.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.0-0.0-0.1-0.0-0.1-0.1-0.0-0.10.1-0.3-0.1-0.00.2-0.0-0.0
Pavlov. Cond. response bias0.30.30.60.60.60.60.50.60.30.40.60.6-0.60.40.60.70.70.70.7
Pavlov. Cond. lever latency4.05.47.8-2.2-2.2-2.4-2.2-2.4-1.4-1.2-2.4-2.22.6-2.8-2.5-2.5-2.3-2.5-2.6
Pavlov. Cond. magazine entry latency0.10.10.50.40.30.10.30.10.70.70.10.2-0.00.20.0-0.0-0.1-0.1-0.1
Pavlov. Cond. change in total contacts2.74.46.91.92.02.11.92.21.21.12.22.0-2.42.62.32.32.02.32.4
Pavlov. Cond. index score2.73.65.21.91.92.01.82.01.41.32.01.9-2.02.32.02.01.82.02.0
Pavlov. Cond. latency score2.22.94.31.81.71.71.61.71.31.21.81.7-1.82.11.81.81.51.71.7
Pavlov. Cond. lever contacts3.54.87.32.22.12.32.12.31.51.32.32.2-2.42.72.32.32.12.32.3
Pavlov. Cond. magazine entry number0.60.71.4-1.0-0.8-0.8-0.7-0.9-0.6-0.7-0.8-0.80.9-1.2-0.9-0.9-0.8-0.9-0.8
Pavlov. Cond. intertrial magazine entries0.60.91.2-1.0-0.9-1.0-1.0-1.0-0.5-0.4-1.1-1.11.1-0.9-1.0-1.0-0.8-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.2.33.14.81.81.71.81.61.81.31.21.81.7-1.92.21.91.81.61.81.8
Pavlov. Cond. response bias3.85.27.42.32.32.42.32.41.71.62.42.3-2.42.72.42.42.22.42.4
Time in closed arm before self-admin0.50.61.6-0.9-0.9-0.7-0.8-0.7-1.2-1.3-0.6-0.60.4-0.5-0.7-0.6-0.8-0.5-0.4
Time in closed arm after self-admin1.51.63.8-1.6-1.6-1.4-1.4-1.3-1.9-1.5-1.0-0.91.2-0.9-1.1-1.0-1.0-0.9-0.8
Time in open arm before self-admin0.20.30.8-0.2-0.5-0.4-0.6-0.4-0.7-0.7-0.6-0.90.4-0.5-0.2-0.3-0.5-0.2-0.2
Time in open arm after self-admin0.80.92.81.11.31.01.10.91.71.30.70.6-0.80.60.70.60.40.50.4
Bone: periosteal estimation2.45.06.92.42.32.32.42.31.92.12.52.6-2.22.12.22.22.02.12.0
Bone: periosteal perimeter3.66.28.42.82.72.62.82.52.72.82.62.9-2.22.62.22.22.02.01.8
Bone: post-yield work0.50.81.7-0.7-0.8-0.9-0.8-0.9-0.7-0.6-0.7-0.50.8-1.2-0.8-0.9-1.3-0.9-0.9
Progressive ratio test 1 active lever presses1.31.62.51.41.21.41.31.30.90.91.51.6-1.21.11.31.31.31.31.2
Progressive ratio test 1 breakpoint1.41.72.61.41.21.41.41.40.91.01.51.6-1.21.11.31.31.31.31.2
Progressive ratio test 1 inactive lever presses0.10.20.40.70.40.40.40.40.60.50.40.4-0.30.10.30.30.30.30.2
Progressive ratio test 2 active lever presses0.40.50.90.80.60.70.90.70.60.90.81.0-0.50.70.50.50.50.40.4
Progressive ratio test 2 breakpoint0.50.51.00.90.60.80.90.80.71.00.81.0-0.60.70.50.60.60.50.4
Progressive ratio test 2 inactive lever presses0.71.13.21.51.11.01.21.01.61.80.81.0-0.71.00.80.70.70.50.4
Incentive Sensitization - Responses0.20.31.10.60.40.60.70.50.40.70.71.0-0.40.50.30.40.60.40.3
Incentive Sensitization - Breakpoint0.10.20.80.40.20.40.50.40.30.60.60.9-0.20.30.10.20.40.20.1
Sum of active levers in priming session hrs 5-61.00.91.81.11.21.01.01.01.31.30.70.5-0.90.80.90.90.70.80.7
Progressive ratio3.65.68.2-2.4-2.4-2.3-2.6-2.3-2.4-2.3-2.5-2.92.2-2.6-2.1-2.1-2.6-2.0-1.9
Food seeking constrained by brief footshock0.40.52.81.30.90.50.60.41.71.5-0.0-0.1-0.40.40.20.10.1-0.0-0.2
Seeking ratio, punishment vs. effort3.44.87.52.52.32.22.42.12.72.72.12.4-2.02.31.81.82.21.71.5
Retroperitoneal fat weight0.72.83.6-1.7-1.7-1.7-1.9-1.7-1.7-1.4-1.7-1.81.5-1.9-1.7-1.7-1.7-1.6-1.6
Reaction time number correct0.30.51.40.90.90.70.80.71.21.20.30.2-0.60.80.80.50.10.50.4
Reaction time mean minus median0.30.71.1-1.0-0.7-0.9-0.6-0.9-0.4-0.6-0.9-0.80.9-1.0-0.9-0.9-0.8-0.9-0.9
Reaction time mean minus median AUC0.10.30.6-0.7-0.4-0.6-0.2-0.6-0.0-0.2-0.6-0.60.7-0.8-0.7-0.6-0.5-0.7-0.7
Reaction time num false alarms1.82.54.51.91.91.71.71.72.12.01.21.0-1.51.21.51.51.51.31.2
Reaction time num false alarms AUC1.52.33.21.81.71.71.51.71.81.71.31.1-1.61.11.61.51.51.51.4
Reaction time trials correct on left0.30.51.40.90.90.70.80.71.21.20.30.2-0.60.80.80.50.10.50.4
Reaction time trials on left0.30.61.60.90.90.80.90.71.31.20.30.2-0.70.90.90.60.20.50.4
Reaction time mean0.00.00.2-0.5-0.2-0.10.0-0.1-0.4-0.40.00.00.10.20.10.00.20.10.1
Reaction time mean AUC0.00.00.2-0.5-0.2-0.10.0-0.1-0.3-0.4-0.1-0.10.20.0-0.0-0.10.1-0.00.0
Median of all reaction times0.00.10.3-0.3-0.00.10.20.1-0.2-0.20.20.1-0.10.50.30.20.40.30.3
Reaction time omissions0.71.02.21.11.21.00.91.01.51.20.60.2-0.90.91.00.91.40.80.8
Reaction time false alarm rate0.81.11.71.21.21.11.01.21.11.01.00.9-1.00.60.91.11.31.01.0
Reaction time premature initiation rate0.20.31.1-0.4-0.7-0.6-0.7-0.6-0.8-1.1-0.7-0.70.10.1-0.3-0.4-0.2-0.3-0.2
Reaction time premature initiations0.10.20.7-0.1-0.4-0.4-0.4-0.4-0.3-0.6-0.7-0.80.00.3-0.0-0.2-0.3-0.2-0.2
Std. dev. reaction times0.10.20.4-0.10.20.30.30.3-0.1-0.20.40.4-0.40.30.50.50.60.50.6
Reaction time trials completed0.30.61.60.90.90.80.90.71.31.20.30.2-0.70.90.90.60.20.50.4
Reaction time trials AUC0.40.71.61.01.00.80.90.81.31.20.40.3-0.80.90.90.70.30.60.5
Run reversals in cocaine runway, females0.10.10.30.40.1-0.10.0-0.10.40.4-0.3-0.40.1-0.3-0.3-0.30.5-0.4-0.4
Run reversals in cocaine runway, males1.11.12.21.21.21.01.11.01.51.30.80.8-0.81.50.90.81.10.80.7
Latency to leave start box in cocaine runway0.60.71.3-0.8-1.0-0.8-0.7-0.7-1.0-0.8-0.9-1.20.7-1.0-0.7-0.7-0.6-0.7-0.6
Latency to leave start box in cocaine runway, F1.41.72.7-1.4-1.5-1.2-1.3-1.2-1.5-1.4-1.3-1.41.1-1.7-1.1-1.1-1.1-1.1-1.0
Latency to leave start box in cocaine runway, M0.40.30.60.60.50.60.70.60.30.50.50.2-0.60.80.60.60.70.60.6
Std. dev. time between licks in bursts0.40.61.30.80.80.80.90.70.70.70.80.8-0.71.20.60.70.60.60.6
Total sessions with >9 infusions0.30.41.30.20.40.60.60.60.1-0.10.91.1-0.60.40.50.60.50.60.7
Short access day 1 total inactive lever presses2.33.14.0-1.7-2.0-1.9-1.9-1.9-1.7-1.7-1.7-1.51.8-1.6-1.9-1.8-1.7-1.7-1.7
Short access day 10 total inactive lever presses0.92.12.7-1.2-1.5-1.5-1.5-1.5-1.1-0.6-1.5-1.31.5-1.4-1.6-1.6-1.6-1.6-1.6
Short access day 1 total infusions0.10.10.2-0.4-0.2-0.1-0.0-0.20.1-0.10.00.30.2-0.4-0.4-0.3-0.4-0.4-0.4
Short access day 10 total infusions0.20.31.2-0.5-0.6-0.3-0.6-0.4-0.9-1.1-0.10.00.4-0.8-0.4-0.3-0.4-0.2-0.2
Short access total infusions0.10.10.4-0.10.20.30.20.30.0-0.20.50.6-0.2-0.00.10.20.20.20.2
Short access day 1 locomotion0.50.61.6-0.7-0.5-0.6-0.4-0.70.1-0.1-0.4-0.10.9-1.1-1.0-1.0-1.2-1.0-1.1
Short access day 10 total locomotion0.00.00.3-0.10.0-0.0-0.0-0.00.10.10.10.30.0-0.1-0.1-0.0-0.5-0.0-0.0
Short access total locomotion0.00.00.1-0.10.10.00.1-0.00.40.20.10.30.1-0.2-0.2-0.1-0.3-0.2-0.2
One hour access (0.3 mA shock)0.00.00.10.20.00.1-0.00.00.20.10.00.00.10.00.0-0.10.1-0.1-0.2
Compulsive drug intake1.61.92.8-1.4-1.4-1.5-1.5-1.5-1.2-1.1-1.5-1.71.4-0.7-1.3-1.4-1.3-1.4-1.4
One hour access (shock baseline)0.40.71.01.00.90.90.90.90.80.70.91.0-0.80.40.80.80.70.80.7
Social response proportion1.82.05.11.61.71.41.51.42.12.31.10.9-1.01.51.11.11.41.00.8
Social responses4.76.17.42.62.72.52.42.52.32.52.32.1-2.32.72.62.52.72.42.3
Social time0.30.51.00.50.90.70.70.71.00.70.50.2-0.60.40.70.70.80.70.7
Soleus weight0.10.21.20.30.50.30.70.21.10.80.20.20.00.50.00.00.3-0.1-0.2
Bone: stiffness2.33.84.72.22.02.12.02.01.61.72.01.9-2.02.02.02.01.71.91.9
Tibialis anterior weight1.03.55.02.01.92.02.02.01.41.51.91.9-1.91.61.91.92.21.91.8
Time to tail flick, vehicle, before self-admin1.51.63.6-1.1-1.1-1.1-1.1-1.2-0.5-0.8-1.6-1.91.3-1.3-1.3-1.3-1.3-1.3-1.3
Time to tail flick, vehicle, after self-admin0.70.91.8-1.3-1.1-0.8-0.8-0.9-1.2-1.4-0.7-0.70.8-1.2-1.0-0.8-1.2-0.7-0.7
Time to tail flick, test, before self-admin1.11.22.60.60.91.00.61.10.30.61.11.0-1.11.41.21.21.61.31.4
Time to tail flick, test, after self-admin0.30.30.6-0.5-0.6-0.6-0.5-0.6-0.10.2-0.7-0.60.7-0.6-0.6-0.7-0.5-0.7-0.8
Delta time to tail flick, vehicle, before/after SA2.62.53.81.41.51.61.61.61.01.11.81.9-1.71.51.61.61.31.71.6
Delta time to tail flick, test, before/after SA0.91.01.9-0.6-0.8-1.0-0.6-1.00.0-0.1-1.0-0.81.1-1.2-1.1-1.2-1.3-1.3-1.4
Tibia length4.512.418.13.53.33.73.43.72.12.34.14.2-3.83.13.73.73.53.73.7
Ambulatory time before self-admin2.84.25.32.32.12.12.22.11.92.12.22.3-2.11.92.02.01.42.01.9
Ambulatory time after self-admin3.13.65.41.61.92.02.12.01.71.72.22.3-2.01.81.91.91.51.91.8
Bone: tissue strength0.10.10.30.30.50.40.50.40.50.50.30.2-0.30.30.30.30.30.30.3
Total heroin consumption3.03.54.52.02.12.01.82.01.91.91.51.2-2.01.72.11.91.61.91.8
Bone: trabecular number0.81.42.21.21.21.21.31.21.51.41.00.9-1.11.11.01.01.40.90.8
Bone: trabecular spacing0.10.20.9-0.3-0.5-0.4-0.5-0.3-1.0-0.8-0.3-0.30.2-0.1-0.2-0.2-0.3-0.1-0.0
Bone: trabecular thickness0.60.81.70.90.90.91.00.91.31.30.80.9-0.70.60.70.71.00.60.5
Bone: trabecular tissue density1.92.83.41.81.81.81.61.81.41.81.61.6-1.71.61.71.71.61.61.5
Water consumed over 24 hours0.10.10.4-0.2-0.3-0.3-0.3-0.2-0.5-0.3-0.1-0.10.1-0.7-0.2-0.2-0.3-0.1-0.1
Number of responses in last shaping day0.00.00.10.00.20.20.30.20.40.2-0.1-0.2-0.10.20.20.10.20.10.1