Hub : Genes

Ebf4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Ebf4 0.46 0.26 3.4e-04 0.04 0.12 0.09 0.07 4.7e-02 8.8e-04 3.1e-03 7.6e-03
2 NAcc gene expression Ebf4 0.06 0.05 3.5e-06 0.03 0.04 0.04 0.04 6.6e-04 2.2e-05 2.9e-05 2.6e-05
3 PL gene expression Ebf4 0.19 0.09 0.0e+00 0.18 0.2 0.2 0.22 5.4e-19 1.6e-21 3.0e-21 3.0e-23
4 Brain gene expression Ebf4 0.18 0.11 0.0e+00 0.17 0.18 0.17 0.17 1.7e-15 3.7e-16 1.1e-15 1.1e-15
5 PL mRNA stability Ebf4 0.13 0.07 0.0e+00 0.13 0.15 0.14 0.14 5.1e-14 1.5e-16 1.6e-15 1.7e-15
6 OFC mRNA stability Ebf4 0.18 0.13 2.6e-03 0.09 0.07 0.06 0.06 3.9e-03 1.1e-02 1.3e-02 1.9e-02
7 Liver gene expression Ebf4 0.48 0.13 0.0e+00 0.42 0.43 0.43 0.43 4.5e-51 1.2e-52 4.7e-52 2.5e-52
8 Brain mRNA stability Ebf4 0.19 0.11 0.0e+00 0.2 0.19 0.18 0.19 4.7e-18 2.7e-17 2.0e-16 4.6e-17
9 OFC gene expression Ebf4 0.24 0.14 7.4e-05 0.19 0.2 0.15 0.19 2.7e-05 1.6e-05 2.1e-04 3.5e-05
10 Liver alternative TSS NM_001191076.2 0.02 0.02 3.4e-03 0.01 0.01 0 0.01 8.1e-03 1.7e-02 1.2e-01 2.1e-02
11 Liver mRNA stability Ebf4 0.03 0.02 6.3e-04 0.01 0.01 0.01 0 3.0e-02 1.7e-02 6.2e-02 8.2e-02
12 BLA gene expression Ebf4 0.24 0.16 2.6e-09 0.15 0.03 0.13 0.11 2.9e-08 7.8e-03 1.6e-07 2.3e-06
13 PL alternative TSS XM_039105852.1 0.02 0.02 8.2e-03 0.01 0.01 0.01 0.01 1.4e-02 8.9e-03 4.6e-02 3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.50.91.91.31.31.41.01.0-0.8-0.8-0.70.8-0.70.7-0.70.6
Area under the delay curve0.40.40.9-0.8-0.9-1.0-0.7-0.60.50.50.5-0.50.4-0.40.4-0.4
BMI with tail1.23.85.51.71.81.81.91.9-2.3-1.9-2.01.9-2.31.9-1.91.9
BMI without tail3.87.910.72.62.72.62.82.8-3.1-2.7-2.92.8-3.32.8-2.62.7
Body weight6.125.627.74.95.04.75.15.1-5.2-5.1-5.35.1-5.15.1-5.05.0
Weight adjusted by age3.94.45.92.42.32.02.32.2-2.0-2.3-2.12.1-1.22.0-2.11.9
Bone surface0.81.42.31.51.51.51.31.2-1.2-1.2-1.01.1-0.91.0-1.00.9
Bone volume0.81.32.21.51.41.51.21.2-1.1-1.1-1.01.1-0.90.9-1.00.9
Breakpoint value in progressive ratio session2.93.24.91.51.61.41.81.8-1.9-1.8-1.91.8-2.21.9-1.61.9
Number of licking bursts0.30.40.9-0.9-0.8-1.0-0.7-0.60.70.50.3-0.50.6-0.30.4-0.3
Context. condit. distance diff. score0.10.10.50.70.60.60.40.3-0.3-0.2-0.20.20.00.0-0.1-0.1
Locomotion velocity, session 10.30.40.70.80.70.50.70.6-0.6-0.7-0.50.6-0.30.5-0.60.5
Locomotion distance, session 10.40.61.71.31.21.10.90.8-0.6-0.6-0.40.6-0.40.3-0.40.1
Locomotion velocity, session 20.10.10.2-0.1-0.1-0.2-0.2-0.20.10.30.4-0.20.4-0.30.3-0.3
Locomotion distance, session 21.62.23.71.81.91.91.61.5-1.3-1.4-1.21.4-1.51.1-1.21.0
Locomotion velocity, session 31.31.52.31.11.11.11.21.2-1.5-1.2-1.21.2-1.11.2-1.21.2
Locomotion distance, session 36.77.39.52.52.72.62.72.7-3.1-2.6-2.82.7-2.82.7-2.72.6
Stereotopy head waving bouts, day 30.91.12.1-0.4-0.7-0.5-0.9-0.91.40.91.3-1.01.4-1.21.0-1.3
Stereotopy head waving duration, day 30.70.81.6-0.5-0.7-0.6-0.8-0.81.20.81.1-0.91.1-0.90.8-1.0
Locomotion velocity, session 71.01.11.31.11.11.01.11.1-1.0-1.1-0.91.0-1.01.0-1.10.9
Locomotion distance, session 70.70.91.51.11.21.11.11.0-1.2-0.9-0.80.9-1.10.7-0.80.6
Stereotopy head waving bouts, day 70.50.50.70.70.60.60.70.7-0.5-0.8-0.80.8-0.70.8-0.80.8
Stereotopy head waving duration, day 70.10.10.30.30.20.30.30.4-0.1-0.5-0.50.4-0.30.5-0.50.5
Locomotion velocity, session 80.60.71.81.31.21.10.90.8-0.7-0.7-0.50.6-0.40.4-0.60.3
Locomotion distance, session 82.63.87.22.72.62.52.12.0-1.9-1.8-1.61.7-1.61.4-1.51.1
Degree of sensitization distance2.02.02.6-1.1-1.2-1.3-1.3-1.41.51.41.6-1.51.4-1.61.5-1.6
Degree of sensitization stereotypy2.32.53.31.21.31.21.51.6-1.5-1.6-1.71.6-1.71.8-1.71.8
Conditioned locomotion4.65.47.92.82.62.62.42.4-2.2-2.4-2.22.2-2.02.1-2.12.0
Cocaine response after cond. corrected0.10.10.2-0.0-0.1-0.2-0.2-0.30.20.30.5-0.40.5-0.40.4-0.5
Cocaine response after cond. not corrected0.20.20.3-0.3-0.3-0.4-0.4-0.40.40.40.6-0.50.6-0.50.5-0.5
Cocaine response before conditioning0.20.20.5-0.7-0.6-0.5-0.5-0.50.70.40.4-0.40.1-0.30.3-0.3
Saline control response7.69.911.43.43.23.13.23.2-3.2-3.2-3.23.1-3.13.0-3.02.9
Bone: connectivity density0.30.41.10.90.91.10.70.7-0.4-0.5-0.40.5-0.50.4-0.40.3
Bone: cortical apparent density0.60.71.40.30.50.40.70.8-0.9-0.8-0.91.0-1.01.1-1.01.2
Bone: cortical area3.55.36.92.32.32.22.32.3-2.6-2.3-2.32.3-2.32.2-2.22.2
Bone: cortical porosity0.10.10.4-0.4-0.3-0.40.00.1-0.7-0.2-0.40.2-0.30.4-0.30.5
Bone: cortical porosity0.40.41.1-0.00.1-0.00.40.5-1.1-0.6-0.70.6-0.80.8-0.70.9
Bone: cortical thickness1.52.53.81.51.51.41.51.6-2.0-1.5-1.61.6-1.61.6-1.51.6
Bone: cortical thickness0.30.30.40.40.50.40.50.6-0.6-0.6-0.60.6-0.50.6-0.60.7
Bone: cortical tissue density0.40.61.10.20.40.30.60.7-0.8-0.7-0.80.8-0.91.0-0.91.1
Condit. Reinf. active minus inactive responses0.70.81.20.50.70.70.80.9-1.1-0.8-0.80.9-1.11.0-1.01.0
Condit. Reinf. active-inactive response ratio0.80.91.20.80.91.10.90.9-0.9-0.9-0.80.9-1.10.9-0.90.9
Condit. Reinf. active responses0.50.61.20.40.60.50.70.7-1.1-0.7-0.70.8-0.90.9-0.80.9
Condit. Reinf. inactive responses0.00.00.00.10.0-0.10.00.0-0.1-0.0-0.10.0-0.0-0.00.0-0.0
Incentive salience index mean0.40.51.30.50.60.60.70.7-1.1-0.7-0.60.7-0.80.7-0.70.8
Condit. Reinf. lever presses0.10.10.60.10.10.20.20.2-0.8-0.3-0.30.3-0.40.3-0.20.3
Condit. Reinf. active minus inactive responses2.83.55.12.12.12.31.91.9-1.3-1.9-1.71.9-2.01.7-1.81.6
Condit. Reinf. active-inactive response ratio2.72.83.71.81.81.91.71.7-1.2-1.7-1.61.7-1.81.6-1.71.5
Condit. Reinf. active responses4.46.18.42.72.72.92.62.5-1.8-2.5-2.32.5-2.62.3-2.42.2
Condit. Reinf. inactive responses0.91.11.81.31.31.31.11.1-0.7-1.1-0.91.0-0.90.9-1.00.8
Condit. Reinf. lever presses1.62.12.51.31.41.41.51.5-1.2-1.5-1.51.5-1.61.5-1.51.6
Condit. Reinf. lever reinforcers received3.54.97.12.52.42.72.32.2-1.6-2.2-2.02.2-2.32.0-2.11.9
Conditioned reinforcement - actives0.00.00.00.10.10.10.10.10.1-0.1-0.20.10.00.1-0.00.1
Conditioned reinforcement - inactives0.70.72.31.31.21.50.90.9-0.4-0.8-0.40.7-0.80.5-0.60.4
Conditioned locomotion0.10.10.1-0.1-0.2-0.1-0.3-0.30.30.30.3-0.3-0.0-0.30.4-0.3
Patch foraging indifference point 0 sec0.30.41.61.20.91.30.60.60.0-0.6-0.20.4-0.20.2-0.40.1
Patch foraging indifference point AUC0.60.60.90.70.70.80.80.8-0.9-0.8-0.70.8-1.00.8-0.80.8
Delay disc. indifference point, 0s delay3.03.35.0-1.9-2.0-2.2-1.9-1.91.71.81.7-1.81.4-1.71.8-1.7
Delay disc. indifference point, 16s delay0.80.81.3-1.2-1.1-1.1-1.0-1.00.70.90.7-0.90.7-0.80.8-0.7
Delay disc. indifference point, 2s delay0.00.00.2-0.2-0.3-0.5-0.2-0.20.10.10.1-0.20.2-0.10.1-0.1
Delay disc. indifference point, 24s delay2.92.83.5-1.9-1.8-1.9-1.7-1.71.41.71.6-1.61.8-1.51.5-1.5
Delay disc. indifference point, 4s delay0.10.10.3-0.3-0.3-0.2-0.0-0.0-0.2-0.1-0.10.1-0.50.2-0.20.3
Delay disc. indifference point, 8s delay0.40.51.1-1.0-1.0-1.0-0.8-0.70.50.50.5-0.60.4-0.40.4-0.3
Indifference point function ln k0.10.10.40.60.50.40.40.4-0.4-0.3-0.20.30.00.2-0.30.1
Indifference point function log k0.10.10.40.60.50.40.40.4-0.4-0.3-0.20.30.00.2-0.30.1
Patch foraging total patch changes 0 sec0.30.51.71.21.01.30.70.6-0.0-0.6-0.30.4-0.20.2-0.40.1
Patch foraging total patch changes 12 sec0.40.61.00.90.81.00.80.8-0.8-0.8-0.70.7-0.60.7-0.60.6
Patch foraging total patch changes 18 sec0.50.71.1-0.4-0.5-0.5-0.7-0.81.00.81.0-0.90.9-1.01.0-1.1
Patch foraging total patch changes 24 sec1.21.52.3-0.6-0.8-0.7-1.1-1.11.51.11.4-1.31.4-1.41.3-1.5
Patch foraging total patch changes 6 sec0.81.23.31.61.41.81.11.1-0.6-1.0-0.70.9-1.10.7-0.80.6
Patch foraging time to switch 0 sec2.53.86.3-2.5-2.3-2.4-2.1-2.01.62.01.7-1.91.7-1.71.8-1.5
Patch foraging water rate 0 sec5.08.013.13.63.33.63.02.9-2.3-2.9-2.62.7-2.42.4-2.62.2
Patch foraging water rate 12 sec0.10.20.50.70.70.50.50.40.0-0.4-0.10.40.30.2-0.30.1
Patch foraging water rate 18 sec0.40.50.80.90.80.90.70.7-0.6-0.7-0.70.7-0.40.7-0.70.6
Patch foraging water rate 24 sec0.50.61.00.60.70.60.80.8-0.7-0.9-1.00.9-0.50.9-0.90.9
Patch foraging water rate 6 sec2.03.03.51.91.81.51.81.8-1.5-1.8-1.81.8-1.31.7-1.81.7
Seeking ratio, delayed vs. immediate footshock0.30.30.9-0.6-0.5-1.0-0.5-0.50.50.50.4-0.40.9-0.40.4-0.4
Distance traveled before self-admin5.55.88.62.92.72.72.52.5-2.3-2.5-2.52.3-2.42.2-1.32.0
Distance traveled after self-admin3.33.74.72.22.12.02.01.9-1.8-1.9-2.11.8-2.11.7-1.61.6
Extensor digitorum longus weight0.10.20.30.40.50.20.50.5-0.5-0.4-0.50.5-0.40.5-0.50.5
Bone: elastic displacement0.10.10.4-0.7-0.4-0.4-0.2-0.20.10.10.00.0-0.30.1-0.10.2
Bone: elastic work0.00.00.1-0.3-0.1-0.10.00.1-0.2-0.1-0.20.2-0.40.3-0.20.3
Bone: endosteal estimation0.51.11.61.31.21.11.11.1-1.2-1.1-1.01.0-0.91.0-1.00.9
Bone: endosteal perimeter2.44.96.12.52.42.32.32.3-2.2-2.2-2.22.1-2.12.0-2.12.0
Epididymis fat weight1.43.23.81.91.81.61.81.8-1.9-1.9-1.71.8-1.51.8-1.81.7
Delta time in closed arm before/after self-admin0.30.30.4-0.7-0.6-0.3-0.6-0.50.50.50.6-0.5-0.0-0.50.5-0.4
Delta time in open arm before/after self-admin1.11.12.91.71.61.21.21.2-0.8-1.0-1.10.9-0.00.7-0.40.5
Diff in mean of infusions in LGA sessions0.10.10.2-0.5-0.3-0.4-0.2-0.2-0.00.20.3-0.1-0.3-0.1-0.0-0.1
Delay discount exponential model param0.30.30.80.80.80.90.60.6-0.4-0.5-0.40.5-0.30.4-0.40.3
Extinction: sum of active levers before priming0.70.71.80.80.80.90.80.9-0.7-0.9-0.80.9-1.30.9-0.00.9
Active lever presses in extinction session 60.20.21.5-0.0-0.2-0.3-0.3-0.30.30.30.1-0.5-0.0-0.51.2-0.5
Bone: final force3.76.07.42.52.42.32.52.5-2.7-2.5-2.52.4-2.42.4-2.42.4
Bone: final moment2.94.66.12.22.22.02.22.2-2.5-2.2-2.22.1-2.12.1-2.12.1
Food consumed during 24 hour testing period0.80.91.4-0.7-0.8-0.6-1.0-0.91.21.00.9-1.01.0-1.11.1-1.1
Glucose0.50.71.51.11.01.20.80.8-0.7-0.7-0.70.7-1.10.6-0.60.5
Heart weight3.75.38.02.72.72.82.42.4-2.3-2.2-2.12.2-1.82.0-2.01.8
Delay discount hyperbolic model param0.20.30.60.70.80.80.60.5-0.3-0.4-0.40.5-0.30.4-0.30.3
Intermittent access intake day 1-15 change0.50.50.90.90.90.80.70.7-0.7-0.7-0.70.6-0.60.6-0.60.5
Intermittent access intake escalation0.10.10.30.50.50.50.40.4-0.2-0.4-0.30.3-0.40.3-0.30.3
Intermittent access intake escalation 20.20.20.3-0.4-0.3-0.3-0.4-0.40.40.50.5-0.50.3-0.50.5-0.5
Intermitt. access day 1 inactive lever presses0.20.20.60.1-0.10.6-0.3-0.30.80.30.6-0.40.1-0.50.4-0.5
Intermitt. access day 15 inactive lever presses0.10.10.70.50.40.80.10.10.2-0.00.2-0.1-0.7-0.20.2-0.3
Intermitt. access escalation Index0.00.00.2-0.3-0.2-0.4-0.2-0.1-0.10.10.0-0.10.1-0.00.10.0
Intermittent access day 1 total infusions0.10.20.5-0.5-0.4-0.7-0.4-0.40.00.40.2-0.40.0-0.30.4-0.3
Intermittent access day 15 total infusions0.00.00.10.30.30.10.20.1-0.1-0.1-0.10.1-0.30.00.0-0.0
Intermittent access terminal intake (last 3 days)0.00.00.10.30.30.20.10.1-0.10.0-0.0-0.0-0.3-0.10.1-0.2
Intermittent access total infusions0.00.00.10.10.0-0.1-0.1-0.1-0.00.20.1-0.2-0.1-0.30.3-0.3
Intermittent access day 1 locomotion0.10.10.2-0.2-0.3-0.2-0.3-0.30.50.30.4-0.30.1-0.40.3-0.4
Intermittent access day 15 total locomotion0.10.10.30.50.30.50.0-0.00.30.10.4-0.20.0-0.40.3-0.5
Intermittent access total locomotion0.10.10.20.0-0.1-0.2-0.2-0.20.30.30.4-0.40.2-0.40.4-0.5
Intermittent access standard deviation0.10.10.60.10.20.20.20.2-0.2-0.2-0.30.3-0.70.3-0.30.3
Left kidney weight1.13.14.52.12.02.01.81.8-1.8-1.7-1.61.6-1.71.5-1.51.4
Right kidney weight1.13.14.72.12.02.21.81.7-1.6-1.7-1.71.6-2.11.4-1.41.3
Cocaine induced anxiety4.65.37.5-1.8-2.1-1.4-2.3-2.42.72.42.7-2.51.9-2.62.4-2.6
Post-drug Anxiety1.31.52.7-1.0-1.1-0.6-1.2-1.31.61.31.3-1.30.8-1.41.2-1.4
Baseline Anxiety0.50.61.10.50.70.40.80.8-0.8-0.8-1.00.8-0.40.9-0.80.9
Tail length4.814.717.33.53.73.33.83.9-4.0-3.8-4.23.9-4.03.9-3.83.9
Length with tail4.817.519.64.34.33.94.34.3-4.2-4.3-4.44.2-3.84.1-4.14.1
Length without tail1.43.13.61.91.81.81.81.8-1.6-1.9-1.81.8-1.31.7-1.81.6
Times rat made contact with spout0.00.00.10.30.20.30.00.00.40.00.1-0.10.3-0.20.1-0.2
Lifetime Intake0.10.10.40.50.40.20.40.3-0.5-0.3-0.50.2-0.60.2-0.20.2
Liver weight, left0.10.10.30.40.30.30.0-0.10.30.20.1-0.3-0.1-0.40.3-0.5
Liver weight, right0.00.10.3-0.1-0.1-0.30.00.0-0.4-0.1-0.20.1-0.50.2-0.10.2
Locomotor activity0.10.20.30.30.30.60.40.4-0.4-0.5-0.40.5-0.40.5-0.60.6
Locomotor testing distance0.10.10.3-0.2-0.30.2-0.3-0.30.60.30.4-0.30.3-0.30.2-0.3
Locomotor testing rearing0.30.51.70.90.91.30.70.7-0.2-0.7-0.50.7-0.60.5-0.60.5
Locomotion in novel chamber0.10.10.2-0.5-0.4-0.4-0.4-0.40.30.40.3-0.30.4-0.30.2-0.3
Locomotion in novel chamber post-restriction1.21.42.11.21.11.51.21.2-0.9-1.2-1.01.2-1.11.2-1.31.2
Fecal boli incidents, locomotor time 10.10.10.10.20.20.20.20.2-0.3-0.3-0.40.3-0.30.3-0.30.3
Change in fecal boli incidents, locomotor task0.10.10.4-0.3-0.2-0.5-0.2-0.20.30.20.4-0.20.6-0.30.3-0.3
Time >=10cm from walls, locomotor time 10.10.10.30.10.10.20.20.2-0.3-0.2-0.20.2-0.50.3-0.30.3
Bouts of movement, locomotor time 12.52.73.7-1.9-1.8-1.9-1.7-1.71.41.71.6-1.71.2-1.51.6-1.5
Total resting periods, locomotor time 11.92.13.3-1.8-1.7-1.7-1.5-1.51.31.51.4-1.41.1-1.31.4-1.2
Rest time, locomotor task time 10.30.30.7-0.8-0.7-0.7-0.6-0.60.50.50.6-0.50.5-0.40.5-0.4
Distance moved, locomotor task time 10.10.10.40.40.30.60.20.2-0.2-0.2-0.20.1-0.40.1-0.10.0
Vertical activity count, locomotor time 10.20.20.90.80.60.90.50.5-0.6-0.4-0.30.3-0.40.2-0.30.1
Time >=10cm from walls, locomotor time 20.00.00.0-0.2-0.1-0.2-0.1-0.1-0.10.1-0.1-0.1-0.1-0.10.1-0.1
Bouts of movement, locomotor time 20.80.81.8-1.3-1.2-1.3-1.0-0.90.70.90.7-0.80.6-0.70.8-0.6
Total resting periods, locomotor time 20.80.92.1-1.5-1.2-1.4-1.0-0.90.70.90.6-0.80.5-0.60.7-0.5
Rest time, locomotor task time 20.50.61.3-1.2-1.0-1.0-0.8-0.71.10.60.6-0.50.5-0.40.4-0.2
Distance moved, locomotor task time 20.10.10.40.60.50.60.20.1-0.40.00.1-0.10.0-0.30.3-0.4
Vertical activity count, locomotor time 20.50.51.91.21.01.40.70.6-0.7-0.5-0.30.3-0.60.1-0.2-0.0
Light reinforcement 10.91.72.31.01.11.11.31.3-1.1-1.4-1.41.4-1.51.4-1.41.5
Light reinforcement 20.70.91.20.80.90.80.90.9-0.8-1.0-1.01.0-1.11.0-1.01.0
Bone: marrow area0.51.11.61.31.21.11.11.1-1.1-1.0-1.01.0-0.90.9-1.00.8
Bone: maximum diameter4.78.69.93.23.13.03.03.0-3.0-3.0-2.92.9-2.82.8-2.82.7
Bone: maximum force0.71.21.71.31.11.11.11.1-1.3-1.1-1.11.0-1.01.0-1.01.0
Bone: maximum moment0.30.50.90.90.80.70.70.7-0.9-0.7-0.70.6-0.60.6-0.60.6
Mean time between licks in bursts0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.30.10.1-0.10.1-0.0-0.0-0.0
Mean num. licks in bursts0.30.41.31.11.01.10.70.6-0.4-0.5-0.30.4-0.40.2-0.30.1
Cd content in liver0.10.10.3-0.6-0.30.0-0.3-0.30.10.50.4-0.30.0-0.30.3-0.3
Co content in liver0.81.01.21.01.11.11.01.0-0.9-1.0-0.91.0-1.00.9-1.00.9
Cu content in liver2.22.63.11.71.81.61.71.7-1.5-1.7-1.61.7-1.31.6-1.61.5
Fe content in liver0.00.00.10.30.20.40.10.1-0.1-0.1-0.00.00.0-0.10.0-0.1
K content in liver0.30.30.50.50.60.30.60.5-0.7-0.5-0.50.5-0.30.5-0.50.5
Mg content in liver1.81.82.21.51.51.41.41.4-1.5-1.3-1.31.3-1.21.3-1.31.2
Mn content in liver2.02.32.91.41.51.41.51.5-1.7-1.5-1.41.5-1.51.5-1.51.5
Na content in liver0.10.10.2-0.2-0.2-0.4-0.2-0.2-0.20.30.2-0.30.4-0.30.3-0.3
Rb content in liver4.35.48.12.82.82.82.52.4-2.0-2.3-2.12.2-1.92.0-2.21.8
Se content in liver0.91.01.41.21.21.11.11.1-0.9-1.0-1.01.0-0.81.0-1.00.9
Sr content in liver0.50.51.20.50.50.80.60.6-0.7-0.7-0.70.7-1.10.7-0.60.7
Zn content in liver0.30.30.50.60.60.70.60.5-0.7-0.5-0.50.5-0.50.4-0.40.4
Bone: minimum diameter1.73.24.51.91.91.81.81.8-2.1-1.8-1.71.7-1.61.6-1.71.6
Time in familiar zone, hab. session 11.41.31.6-1.1-1.0-1.1-1.1-1.11.01.21.3-1.11.2-1.21.1-1.2
Time in novel zone, hab. session 10.50.50.70.80.80.80.80.7-0.6-0.7-0.70.7-0.60.6-0.70.6
Total zone transitions, hab. session 10.20.20.50.60.70.60.50.5-0.7-0.4-0.20.4-0.50.3-0.30.2
Total locomotion distance, hab. session 10.10.10.30.60.60.60.40.3-0.2-0.20.00.2-0.2-0.0-0.1-0.1
Locomotion velocity, hab. session 10.10.20.50.70.70.70.50.4-0.3-0.3-0.20.3-0.40.1-0.20.0
Time in familiar zone, hab. session 21.61.61.9-1.2-1.2-1.0-1.3-1.31.31.41.3-1.31.2-1.41.3-1.4
Time in novel zone, hab. session 21.61.61.81.21.21.01.31.3-1.2-1.4-1.31.3-1.11.4-1.31.4
Total zone transitions, hab. session 22.43.24.31.71.81.61.81.8-2.1-1.7-1.81.8-1.81.7-1.71.7
Total locomotion distance, hab. session 20.91.12.21.51.41.41.21.1-1.0-1.0-0.81.0-0.90.8-0.80.6
Locomotion velocity, hab. session 20.40.61.41.21.11.10.90.8-0.6-0.7-0.50.6-0.60.4-0.40.2
Novel to familiar place preference ratio0.10.10.3-0.0-0.1-0.2-0.3-0.30.50.40.4-0.40.3-0.50.5-0.6
Novelty place preference0.30.30.6-0.2-0.4-0.4-0.5-0.50.70.60.6-0.70.5-0.70.7-0.8
Time in novel zone, NPP test0.20.20.3-0.1-0.2-0.3-0.4-0.40.50.40.4-0.50.3-0.50.5-0.6
Total zone transitions, NPP test0.10.10.40.20.30.10.40.3-0.7-0.3-0.40.4-0.40.4-0.30.4
Total locomotion distance, NPP test0.30.41.01.01.00.90.70.6-0.5-0.6-0.30.5-0.40.3-0.40.2
Locomotion velocity, NPP test0.10.10.40.60.60.50.30.3-0.1-0.20.00.2-0.0-0.0-0.0-0.1
Intraocular pressure0.00.00.1-0.0-0.0-0.20.10.10.1-0.1-0.20.1-0.10.2-0.20.2
Delta distance traveled before/after self-admin0.20.21.10.20.40.10.40.4-0.5-0.4-0.40.5-0.50.5-1.00.5
Delta ambulatory time before/after self-admin0.60.61.3-1.1-1.0-1.1-0.9-0.90.60.90.8-0.80.4-0.7-0.1-0.6
Parametrial fat weight0.10.20.5-0.4-0.5-0.5-0.4-0.4-0.10.50.3-0.50.7-0.50.5-0.5
Pavlov. Cond. lever latency0.20.20.60.20.30.20.40.50.1-0.6-0.50.6-0.40.7-0.70.8
Pavlov. Cond. magazine entry latency0.10.10.20.20.30.30.30.3-0.3-0.2-0.20.3-0.40.2-0.20.2
Pavlov. Cond. change in total contacts0.00.00.20.20.30.30.20.2-0.5-0.1-0.10.2-0.10.1-0.10.1
Pavlov. Cond. index score0.00.00.10.00.00.1-0.0-0.0-0.30.10.0-0.1-0.1-0.10.1-0.1
Pavlov. Cond. latency score0.10.10.2-0.1-0.1-0.1-0.2-0.2-0.10.30.3-0.30.2-0.40.4-0.4
Pavlov. Cond. lever contacts0.10.10.50.40.30.40.20.2-0.7-0.2-0.20.1-0.30.1-0.00.0
Pavlov. Cond. magazine entry number0.50.61.0-0.4-0.6-0.5-0.7-0.80.90.80.9-0.81.0-0.90.8-1.0
Pavlov. Cond. intertrial magazine entries0.10.20.40.60.60.50.50.4-0.1-0.4-0.30.4-0.30.3-0.40.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.1-0.0-0.0-0.1-0.1-0.30.10.1-0.1-0.1-0.10.1-0.1
Pavlov. Cond. response bias0.40.50.90.60.70.70.70.7-0.9-0.6-0.70.7-0.90.7-0.60.6
Pavlov. Cond. lever latency4.25.76.5-2.1-2.2-2.2-2.3-2.42.42.42.6-2.42.6-2.52.4-2.5
Pavlov. Cond. magazine entry latency0.10.20.50.60.50.70.40.4-0.3-0.4-0.30.3-0.20.2-0.30.2
Pavlov. Cond. change in total contacts4.05.56.22.12.22.12.32.4-2.3-2.4-2.52.4-2.32.5-2.52.5
Pavlov. Cond. index score3.54.54.92.02.02.12.12.1-2.2-2.2-2.22.1-2.12.1-2.22.1
Pavlov. Cond. latency score2.83.53.61.81.81.91.81.9-1.9-1.9-1.91.8-1.91.8-1.91.8
Pavlov. Cond. lever contacts4.25.76.42.32.32.32.42.4-2.3-2.5-2.52.4-2.52.4-2.42.4
Pavlov. Cond. magazine entry number0.70.81.0-0.9-0.9-1.0-0.9-0.90.80.90.9-0.90.9-0.90.9-0.9
Pavlov. Cond. intertrial magazine entries1.01.31.6-1.1-1.0-1.1-1.1-1.20.91.21.3-1.21.2-1.21.2-1.2
Pavlov. Cond. lever-magazine prob. diff.3.14.04.41.91.92.02.02.0-2.1-2.1-2.02.0-2.02.0-2.02.0
Pavlov. Cond. response bias4.66.26.62.52.52.52.52.5-2.3-2.6-2.62.5-2.52.5-2.52.5
Time in closed arm before self-admin0.30.30.6-0.5-0.6-0.6-0.5-0.50.30.50.4-0.50.8-0.50.4-0.5
Time in closed arm after self-admin0.70.71.4-1.2-1.1-0.9-1.0-0.90.50.90.9-0.90.5-0.80.6-0.7
Time in open arm before self-admin0.20.20.5-0.6-0.7-0.4-0.6-0.60.40.50.6-0.5-0.4-0.40.0-0.4
Time in open arm after self-admin0.30.31.11.00.90.70.60.5-0.1-0.5-0.50.40.10.20.10.1
Bone: periosteal estimation2.55.16.22.42.32.22.32.3-2.5-2.3-2.22.2-2.12.2-2.22.1
Bone: periosteal perimeter3.66.17.72.82.72.62.52.5-2.6-2.5-2.42.4-2.32.2-2.32.1
Bone: post-yield work0.60.81.0-0.7-0.9-0.8-0.9-0.91.00.90.9-1.01.0-1.00.9-0.9
Progressive ratio test 1 active lever presses2.42.53.61.51.61.21.61.6-1.9-1.6-1.71.6-1.71.6-1.51.5
Progressive ratio test 1 breakpoint3.13.34.51.71.81.41.81.8-2.1-1.8-1.91.8-2.01.8-1.71.7
Progressive ratio test 1 inactive lever presses0.40.40.90.90.81.00.70.6-0.3-0.6-0.40.5-0.80.4-0.50.3
Progressive ratio test 2 active lever presses0.20.20.50.70.70.60.50.5-0.7-0.4-0.40.3-0.50.2-0.10.2
Progressive ratio test 2 breakpoint0.20.20.40.60.60.40.40.4-0.7-0.3-0.40.3-0.40.2-0.10.1
Progressive ratio test 2 inactive lever presses0.30.41.50.90.81.20.60.5-0.2-0.5-0.20.4-0.90.2-0.30.1
Incentive Sensitization - Responses0.10.10.50.40.40.30.40.4-0.7-0.3-0.40.3-0.40.3-0.10.2
Incentive Sensitization - Breakpoint0.00.00.30.30.30.10.20.2-0.5-0.1-0.10.1-0.20.00.1-0.0
Sum of active levers in priming session hrs 5-61.21.21.91.41.31.21.21.2-0.9-1.2-1.01.1-1.01.1-0.31.0
Progressive ratio3.03.44.3-2.0-2.0-2.1-1.9-1.92.01.81.6-1.81.7-1.71.7-1.6
Food seeking constrained by brief footshock0.60.72.71.41.11.60.80.7-0.6-0.7-0.30.6-0.80.4-0.50.2
Seeking ratio, punishment vs. effort3.44.27.52.52.32.72.12.1-2.0-2.0-1.61.9-1.91.7-1.81.6
Retroperitoneal fat weight0.00.10.2-0.2-0.2-0.5-0.2-0.2-0.40.30.1-0.30.4-0.30.4-0.3
Reaction time number correct0.40.61.51.21.01.00.80.8-0.3-0.8-0.50.7-0.30.6-0.70.5
Reaction time mean minus median0.70.91.4-0.9-0.9-0.8-1.0-1.01.21.01.0-1.01.0-1.00.9-1.0
Reaction time mean minus median AUC0.40.61.1-0.6-0.6-0.6-0.7-0.71.00.70.8-0.70.9-0.80.7-0.8
Reaction time num false alarms2.23.04.32.01.92.11.81.8-1.8-1.7-1.61.6-1.61.5-1.61.4
Reaction time num false alarms AUC2.23.03.61.81.81.91.81.8-1.9-1.8-1.71.7-1.61.6-1.61.6
Reaction time trials correct on left0.40.61.51.21.01.00.80.8-0.3-0.8-0.50.7-0.30.6-0.70.5
Reaction time trials on left0.50.71.61.31.01.10.90.9-0.4-0.9-0.60.8-0.40.7-0.80.6
Reaction time mean0.00.00.2-0.3-0.3-0.4-0.2-0.20.20.10.1-0.10.0-0.00.0-0.0
Reaction time mean AUC0.00.10.2-0.4-0.3-0.4-0.2-0.20.30.20.1-0.20.0-0.10.1-0.1
Median of all reaction times0.00.00.1-0.00.1-0.20.10.1-0.1-0.1-0.20.2-0.10.2-0.20.2
Reaction time omissions0.50.71.40.90.91.20.90.8-0.5-0.8-0.80.8-1.00.7-0.80.7
Reaction time false alarm rate1.01.42.21.11.21.21.21.2-1.5-1.1-1.21.1-1.31.1-1.11.1
Reaction time premature initiation rate0.20.30.6-0.8-0.7-0.8-0.6-0.50.60.50.6-0.40.8-0.30.3-0.2
Reaction time premature initiations0.10.10.5-0.2-0.3-0.3-0.2-0.20.50.20.4-0.20.7-0.10.1-0.1
Std. dev. reaction times0.10.10.2-0.00.1-0.00.20.2-0.2-0.3-0.30.4-0.30.4-0.40.5
Reaction time trials completed0.50.71.61.31.01.10.90.9-0.4-0.9-0.60.8-0.40.7-0.80.6
Reaction time trials AUC0.50.71.71.31.11.10.90.9-0.4-0.9-0.60.8-0.40.7-0.80.7
Run reversals in cocaine runway, females0.10.10.30.40.40.60.20.10.2-0.00.20.1-0.0-0.0-0.1-0.1
Run reversals in cocaine runway, males1.31.22.21.31.21.41.11.1-0.9-1.1-0.91.0-1.50.9-0.90.8
Latency to leave start box in cocaine runway0.60.70.9-0.9-0.9-0.9-0.9-0.90.50.90.7-0.90.5-0.80.9-0.8
Latency to leave start box in cocaine runway, F1.41.51.9-1.3-1.3-1.1-1.3-1.31.01.31.2-1.30.6-1.31.4-1.2
Latency to leave start box in cocaine runway, M0.10.10.10.40.40.20.30.3-0.3-0.3-0.40.3-0.20.2-0.20.2
Std. dev. time between licks in bursts0.50.61.20.90.80.80.80.8-1.1-0.7-0.70.7-0.50.6-0.70.6
Total sessions with >9 infusions0.40.40.80.40.50.20.60.6-0.9-0.6-0.80.6-0.80.7-0.60.7
Short access day 1 total inactive lever presses0.70.81.2-1.1-1.0-0.9-1.0-0.90.90.90.9-0.90.6-0.80.8-0.8
Short access day 10 total inactive lever presses3.03.35.2-1.2-1.4-0.8-1.8-1.82.21.92.2-2.01.4-2.22.1-2.3
Short access day 1 total infusions0.00.00.10.00.1-0.10.10.1-0.3-0.0-0.10.0-0.30.0-0.00.0
Short access day 10 total infusions0.10.10.5-0.2-0.1-0.3-0.1-0.0-0.30.1-0.3-0.1-0.7-0.00.10.0
Short access total infusions0.30.30.60.50.50.00.50.5-0.8-0.5-0.70.5-0.70.5-0.50.5
Short access day 1 locomotion0.80.81.5-0.4-0.5-0.5-0.8-0.80.90.91.0-1.01.0-1.11.0-1.2
Short access day 10 total locomotion0.00.00.00.00.00.00.10.10.1-0.1-0.10.1-0.10.1-0.20.2
Short access total locomotion0.00.00.10.30.30.30.20.10.1-0.1-0.10.1-0.2-0.0-0.1-0.0
One hour access (0.3 mA shock)0.00.00.10.10.1-0.0-0.1-0.10.20.20.1-0.20.3-0.30.3-0.3
Compulsive drug intake4.34.45.3-2.3-2.2-2.2-2.2-2.12.22.12.0-2.02.1-1.92.0-1.9
One hour access (shock baseline)0.40.50.91.00.90.80.80.7-0.7-0.6-0.70.6-0.60.5-0.50.4
Social response proportion2.12.33.51.91.81.81.61.6-1.1-1.5-1.61.4-1.41.3-1.31.2
Social responses5.36.87.52.62.62.52.72.7-2.4-2.7-2.72.6-2.62.6-2.62.5
Social time0.50.61.10.70.80.50.80.8-0.7-0.8-1.00.8-0.60.8-0.80.8
Soleus weight0.00.10.30.50.50.30.40.3-0.0-0.2-0.30.2-0.10.1-0.20.1
Bone: stiffness1.93.04.11.91.81.71.81.7-2.0-1.7-1.71.7-1.61.6-1.61.6
Tibialis anterior weight0.82.83.11.51.81.51.81.7-1.7-1.6-1.71.8-1.71.7-1.71.7
Time to tail flick, vehicle, before self-admin1.92.03.9-1.0-1.1-1.4-1.3-1.31.51.41.6-1.42.0-1.50.9-1.5
Time to tail flick, vehicle, after self-admin0.00.10.4-0.1-0.2-0.3-0.1-0.1-0.00.1-0.1-0.10.0-0.00.7-0.0
Time to tail flick, test, before self-admin1.11.03.30.50.70.70.91.0-1.0-1.0-0.91.1-0.51.2-1.81.2
Time to tail flick, test, after self-admin1.92.02.6-1.1-1.2-1.1-1.4-1.41.61.51.6-1.51.6-1.61.2-1.6
Delta time to tail flick, vehicle, before/after SA3.73.66.61.81.72.11.81.8-2.0-1.9-2.01.9-2.61.9-1.11.9
Delta time to tail flick, test, before/after SA2.52.34.2-0.9-1.1-0.9-1.4-1.41.91.41.5-1.51.6-1.72.0-1.8
Tibia length4.412.514.33.23.43.13.63.6-3.5-3.6-3.83.6-3.63.7-3.73.7
Ambulatory time before self-admin4.54.65.72.42.22.22.22.2-2.1-2.2-2.32.1-2.12.0-2.01.9
Ambulatory time after self-admin3.94.35.22.32.22.02.22.1-2.1-2.1-2.22.0-2.21.9-1.71.9
Bone: tissue strength0.20.20.20.50.40.30.40.4-0.5-0.4-0.40.4-0.30.4-0.30.4
Total heroin consumption3.74.45.22.12.02.02.12.1-2.0-2.2-1.92.1-2.32.1-2.12.1
Bone: trabecular number0.81.21.71.21.31.31.21.2-0.9-1.1-1.01.1-0.91.0-1.00.9
Bone: trabecular spacing0.10.20.4-0.6-0.6-0.5-0.5-0.40.30.40.3-0.40.1-0.30.3-0.2
Bone: trabecular thickness0.50.51.00.90.91.00.80.8-0.8-0.7-0.60.7-0.50.6-0.70.5
Bone: trabecular tissue density1.52.12.71.61.61.51.51.5-1.6-1.5-1.41.4-1.31.4-1.31.3
Water consumed over 24 hours0.10.10.5-0.4-0.4-0.4-0.4-0.30.70.30.2-0.30.4-0.20.3-0.2
Number of responses in last shaping day0.10.10.3-0.4-0.4-0.1-0.4-0.40.60.30.5-0.40.1-0.40.3-0.4