Dus1l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_006247875.3	0.02	0.01	4.9e-03	0	0	0.01	0	1.8e-01	7.8e-02	3.9e-02	3.5e-01
2	Adipose	isoform ratio	XM_006247875.3	0.02	0.01	9.9e-03	-0	0	0	0	4.5e-01	9.1e-02	2.2e-01	3.7e-01
3	Adipose	alternative TSS	XM_006247875.3	0.02	0.01	6.3e-03	0	0	0	-0	2.6e-01	1.3e-01	8.7e-02	3.9e-01
4	Adipose	alternative TSS	NM_172018.2	0.02	0.01	5.7e-03	0	0	0	-0	2.5e-01	1.2e-01	1.1e-01	4.8e-01
5	LHb	gene expression	Dus1l	0.21	0.13	7.0e-03	0.02	0.01	0.01	0.02	1.1e-01	2.3e-01	1.8e-01	1.3e-01
6	Brain	gene expression	Dus1l	0.06	0.04	2.9e-04	0.02	0.04	0.04	0.03	6.1e-03	2.3e-04	7.6e-05	5.0e-04
7	Liver	gene expression	Dus1l	0.05	0.03	1.0e-05	0.01	0.03	0.03	0.03	3.1e-02	2.4e-04	3.7e-04	2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.2	0.4	0.8	-0.8	0.3	-0.6	0.6	0.1	0.9	-0.6
Area under the delay curve	0.5	0.5	1.8	-0.0	-1.3	-0.1	0.1	0.6	0.3	1.1
BMI with tail	0.9	3.0	6.1	-2.5	1.1	-2.1	2.0	-0.4	2.2	-0.1
BMI without tail	3.0	6.1	19.8	1.3	2.8	1.7	-1.7	-0.1	2.8	-4.5
Body weight	1.8	7.6	15.3	-3.1	3.9	-2.5	2.4	-2.8	1.9	-2.1
Weight adjusted by age	1.4	1.6	3.5	-1.2	1.8	-1.0	1.0	-1.9	-0.6	-0.5
Bone surface	0.1	0.2	0.7	0.0	0.6	0.1	-0.1	-0.4	-0.1	-0.9
Bone volume	0.1	0.2	0.8	-0.4	0.5	-0.3	0.2	-0.3	0.4	-0.9
Breakpoint value in progressive ratio session	1.2	1.3	2.5	-1.2	0.9	-1.2	1.2	-1.6	-1.2	0.5
Number of licking bursts	0.2	0.3	0.8	0.3	0.0	0.4	-0.4	0.4	0.9	-0.7
Context. condit. distance diff. score	1.5	1.8	4.3	1.0	0.1	1.2	-1.2	1.1	2.1	-1.6
Locomotion velocity, session 1	1.5	1.6	4.7	-1.0	-1.0	-1.2	1.2	0.1	-1.2	2.2
Locomotion distance, session 1	1.6	2.0	4.7	-0.0	-2.2	-0.1	0.1	2.1	1.9	1.2
Locomotion velocity, session 2	1.6	1.9	5.3	-0.5	-2.3	-0.7	0.7	1.4	-0.2	2.2
Locomotion distance, session 2	0.7	1.0	3.5	-0.4	-1.0	-0.4	0.3	1.4	1.9	0.1
Locomotion velocity, session 3	1.3	1.5	3.9	-1.1	-1.3	-1.2	1.2	0.4	-1.0	2.0
Locomotion distance, session 3	1.6	1.8	4.1	-0.9	-2.0	-1.1	1.0	1.1	0.2	2.0
Stereotopy head waving bouts, day 3	0.6	0.7	1.6	-0.7	-0.6	-0.8	0.8	0.1	-0.9	1.3
Stereotopy head waving duration, day 3	0.2	0.2	0.9	-0.3	-0.5	-0.3	0.3	0.3	-0.4	0.9
Locomotion velocity, session 7	0.3	0.3	1.1	0.0	-1.1	-0.0	0.0	0.7	0.6	0.6
Locomotion distance, session 7	1.9	2.4	6.5	0.7	-2.3	0.6	-0.6	2.6	1.8	0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.5	0.4	-0.4	0.4	-0.3	0.3	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.4	0.7	-0.4	0.4	-0.7	-0.1	-0.1
Locomotion velocity, session 8	1.0	1.1	4.2	0.2	-1.0	0.2	-0.3	1.6	2.0	0.1
Locomotion distance, session 8	2.1	3.1	13.6	0.3	-0.6	0.5	-0.7	2.2	3.7	-1.5
Degree of sensitization distance	1.5	1.5	2.7	1.4	0.5	1.5	-1.5	0.5	1.0	-1.6
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.6	0.6	-0.5	0.5	-0.4	0.6	-0.3
Conditioned locomotion	2.0	2.3	6.9	0.8	2.0	1.1	-1.1	-0.7	1.4	-2.6
Cocaine response after cond. corrected	0.3	0.3	0.4	-0.6	0.1	-0.7	0.7	-0.6	-0.3	0.6
Cocaine response after cond. not corrected	0.2	0.2	0.6	-0.4	-0.5	-0.5	0.5	-0.0	-0.3	0.8
Cocaine response before conditioning	0.5	0.6	1.7	0.5	-1.3	0.5	-0.5	1.2	0.6	0.3
Saline control response	1.3	1.7	4.3	0.8	2.0	0.9	-0.9	-1.3	0.1	-2.1
Bone: connectivity density	0.4	0.6	1.4	0.6	-0.4	0.7	-0.7	0.9	1.2	-0.7
Bone: cortical apparent density	0.9	1.2	3.4	0.2	-1.8	-0.0	0.0	1.0	-0.8	1.8
Bone: cortical area	8.9	13.4	28.9	-5.4	3.3	-4.8	4.7	-2.8	1.5	-0.4
Bone: cortical porosity	4.0	4.3	7.3	-2.1	1.5	-2.1	2.1	-2.6	-2.7	0.9
Bone: cortical porosity	3.0	3.2	5.8	-1.7	1.6	-1.7	1.7	-2.4	-2.3	0.5
Bone: cortical thickness	12.9	21.1	47.5	-6.9	3.3	-6.3	6.2	-3.2	1.1	0.8
Bone: cortical thickness	6.0	6.9	15.4	-3.9	1.6	-3.6	3.5	-1.5	1.1	1.0
Bone: cortical tissue density	1.0	1.4	3.7	0.4	-1.9	0.2	-0.2	1.1	-0.9	1.9
Condit. Reinf. active minus inactive responses	0.8	0.9	2.7	-0.3	1.6	-0.1	0.1	-1.0	0.6	-1.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-0.7	1.0	-0.6	0.6	-0.8	0.5	-0.6
Condit. Reinf. active responses	1.5	1.8	5.2	0.1	2.2	0.3	-0.3	-1.3	0.8	-2.3
Condit. Reinf. inactive responses	0.7	0.9	2.4	0.8	1.1	0.9	-0.8	-0.5	0.3	-1.6
Incentive salience index mean	0.7	0.8	2.4	0.1	1.4	0.3	-0.3	-0.8	0.7	-1.6
Condit. Reinf. lever presses	0.5	0.7	1.0	1.0	-0.3	1.0	-1.0	0.5	0.8	-0.7
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	-0.9	1.1	-0.8	0.8	-0.5	0.7	-0.6
Condit. Reinf. active-inactive response ratio	1.4	1.4	3.4	-1.3	1.8	-1.1	1.1	-1.4	-0.2	-0.6
Condit. Reinf. active responses	0.2	0.2	0.8	-0.4	0.5	-0.3	0.3	0.1	0.9	-0.5
Condit. Reinf. inactive responses	0.3	0.3	0.9	0.2	-0.9	0.2	-0.2	1.0	0.7	0.3
Condit. Reinf. lever presses	0.2	0.3	0.8	0.3	0.2	0.4	-0.4	0.3	0.9	-0.8
Condit. Reinf. lever reinforcers received	0.2	0.3	1.2	-0.1	0.4	-0.0	0.0	0.2	1.1	-0.6
Conditioned reinforcement - actives	0.4	0.4	0.6	0.7	-0.3	0.7	-0.7	0.6	0.8	-0.4
Conditioned reinforcement - inactives	0.5	0.5	1.7	-0.3	1.3	-0.2	0.3	-1.2	-0.2	-0.7
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.0	0.5	-0.5	-0.4	0.2	-0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.6	0.3	0.6	-0.5	-0.2	-0.3	-0.4
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.1	0.0	-0.1	0.1	0.2	0.4	-0.5
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	-0.8	-0.3	-0.8	0.7	-0.0	0.5	0.8
Delay disc. indifference point, 16s delay	1.5	1.5	3.4	0.9	-1.8	0.8	-0.9	1.8	1.2	0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.3	-0.6	-0.4	0.4	-0.4	-0.1	0.7
Delay disc. indifference point, 24s delay	1.7	1.7	5.2	-0.5	-2.1	-0.8	0.8	0.6	-0.6	2.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	-0.3	-0.6	-0.3	0.3	0.0	0.1	0.8
Delay disc. indifference point, 8s delay	0.5	0.5	1.5	-0.6	-0.7	-0.7	0.7	-0.2	-0.2	1.2
Indifference point function ln k	0.5	0.7	1.5	-0.6	-1.2	-0.6	0.6	1.0	0.5	1.1
Indifference point function log k	0.5	0.7	1.5	-0.6	-1.2	-0.6	0.6	1.0	0.5	1.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	0.5	0.3	0.5	-0.5	-0.0	-0.0	-0.4
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	0.5	0.3	0.4	-0.4	-0.5	-0.4	-0.2
Patch foraging total patch changes 18 sec	0.3	0.4	1.0	0.5	-0.4	0.5	-0.5	1.0	0.5	-0.6
Patch foraging total patch changes 24 sec	0.2	0.2	0.6	0.0	0.8	0.1	-0.1	-0.7	0.2	-0.7
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	0.1	0.9	0.1	-0.1	-0.9	-0.7	-0.5
Patch foraging time to switch 0 sec	0.5	0.7	1.4	1.2	-0.8	1.0	-1.0	0.4	-0.8	0.6
Patch foraging water rate 0 sec	0.9	1.5	3.5	-1.0	1.7	-0.7	0.6	-0.8	1.3	-1.9
Patch foraging water rate 12 sec	1.1	1.6	3.4	-1.8	0.2	-1.6	1.5	0.8	1.6	-0.2
Patch foraging water rate 18 sec	0.7	0.9	3.4	-0.9	0.4	-0.7	0.6	0.5	1.9	-1.0
Patch foraging water rate 24 sec	1.0	1.4	4.6	-0.9	1.1	-0.6	0.5	0.4	2.2	-1.6
Patch foraging water rate 6 sec	1.5	2.2	4.9	-2.2	0.0	-2.0	1.9	0.3	1.7	0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.7	0.1	1.3	0.3	-0.3	-0.8	0.5	-1.1
Distance traveled before self-admin	1.2	1.2	2.6	-0.9	1.5	-0.9	0.9	-1.6	-1.1	0.3
Distance traveled after self-admin	2.1	2.3	4.3	2.1	0.6	2.1	-2.0	0.3	-0.4	-1.7
Extensor digitorum longus weight	0.4	1.7	5.1	1.0	-0.3	1.1	-1.1	1.3	2.3	-1.3
Bone: elastic displacement	0.8	0.9	2.3	-0.8	1.4	-0.7	0.7	-1.5	-0.5	-0.2
Bone: elastic work	7.1	9.2	14.2	-3.6	3.7	-3.3	3.3	-3.8	-1.0	-0.2
Bone: endosteal estimation	0.5	1.1	1.4	1.1	-0.3	1.2	-1.2	0.9	1.0	-1.2
Bone: endosteal perimeter	0.3	0.6	1.5	0.4	1.1	0.5	-0.4	-0.9	-0.1	-1.2
Epididymis fat weight	0.3	0.8	2.1	0.3	1.2	0.5	-0.5	-0.5	1.0	-1.5
Delta time in closed arm before/after self-admin	0.3	0.2	0.9	0.4	-0.5	0.4	-0.5	0.2	0.9	-0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.2	-0.1	0.2	-0.2	0.4	0.0	-0.0
Diff in mean of infusions in LGA sessions	0.3	0.4	1.6	0.5	-0.5	0.4	-0.3	-0.0	-1.3	0.4
Delay discount exponential model param	0.6	0.7	2.2	0.2	1.5	0.3	-0.3	-0.6	-0.0	-1.4
Extinction: sum of active levers before priming	2.2	2.2	5.1	-1.6	-1.1	-1.7	1.7	0.5	-1.0	2.3
Active lever presses in extinction session 6	3.4	3.3	5.4	-2.3	-0.2	-2.3	2.3	-1.1	-1.2	2.0
Bone: final force	7.0	11.2	23.5	-4.8	3.2	-4.3	4.2	-2.5	1.7	-0.5
Bone: final moment	7.5	12.2	24.7	-5.0	3.5	-4.4	4.3	-2.9	1.3	-0.6
Food consumed during 24 hour testing period	0.4	0.5	1.3	0.8	0.6	0.8	-0.8	-0.5	-0.1	-1.1
Glucose	4.5	6.8	14.1	-2.5	-0.9	-2.8	2.8	-0.9	-3.2	3.8
Heart weight	1.4	2.0	4.8	-2.2	1.0	-2.0	1.9	-0.6	0.5	0.4
Delay discount hyperbolic model param	0.6	0.7	2.2	0.2	1.5	0.3	-0.3	-0.5	-0.1	-1.4
Intermittent access intake day 1-15 change	1.3	1.2	2.7	1.1	1.1	1.1	-1.0	-0.9	-0.6	-1.7
Intermittent access intake escalation	1.6	1.5	3.4	1.4	0.9	1.4	-1.4	-0.8	-0.4	-1.8
Intermittent access intake escalation 2	1.8	1.7	6.2	-0.0	1.8	-0.0	0.1	-2.5	-1.3	-1.0
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.6	-0.3	1.3	-0.2	0.3	-1.0	-0.7	-0.4
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.5	0.3	0.8	0.4	-0.4	-0.1	0.8	-1.2
Intermitt. access escalation Index	2.0	1.8	2.9	1.6	0.4	1.7	-1.7	0.7	1.1	-1.6
Intermittent access day 1 total infusions	0.1	0.1	0.4	-0.1	0.6	-0.0	0.0	-0.1	0.4	-0.5
Intermittent access day 15 total infusions	0.7	0.8	2.3	0.9	0.8	0.9	-0.9	-0.3	0.3	-1.5
Intermittent access terminal intake (last 3 days)	1.0	1.1	2.5	1.0	1.2	1.0	-1.0	-0.8	-0.2	-1.6
Intermittent access total infusions	0.4	0.5	1.4	0.6	0.7	0.7	-0.7	-0.1	0.4	-1.2
Intermittent access day 1 locomotion	0.2	0.2	0.9	-0.2	0.3	-0.1	0.0	-0.3	1.0	-0.4
Intermittent access day 15 total locomotion	0.3	0.3	1.0	0.1	0.8	0.1	-0.1	-1.0	-0.2	-0.7
Intermittent access total locomotion	0.2	0.2	0.5	-0.1	0.6	-0.1	0.1	-0.7	0.5	-0.6
Intermittent access standard deviation	1.4	1.5	2.5	-1.1	0.0	-1.3	1.3	-1.6	-1.4	1.3
Left kidney weight	1.6	4.4	9.9	-3.1	0.4	-3.0	2.9	-1.3	0.4	1.3
Right kidney weight	1.3	3.5	8.0	-2.8	-0.1	-2.7	2.6	-0.3	0.9	1.4
Cocaine induced anxiety	4.7	5.5	9.6	-2.4	2.9	-2.3	2.4	-3.1	-1.8	0.2
Post-drug Anxiety	1.7	1.9	2.8	-1.6	1.1	-1.6	1.7	-1.5	-0.9	0.8
Baseline Anxiety	3.1	3.3	10.2	0.7	-3.2	0.5	-0.6	2.8	1.3	1.5
Tail length	3.1	9.3	27.2	2.3	3.8	2.7	-2.6	-1.6	1.3	-5.2
Length with tail	0.9	3.4	9.7	-1.2	3.1	-0.9	0.9	-2.8	-0.0	-1.8
Length without tail	4.4	9.5	16.7	-4.1	0.1	-4.1	4.1	-2.0	-1.4	3.4
Times rat made contact with spout	2.2	2.6	6.4	1.3	1.5	1.2	-1.1	-2.0	-2.5	-1.1
Lifetime Intake	0.2	0.3	0.7	0.6	0.3	0.6	-0.6	0.1	0.3	-0.8
Liver weight, left	0.8	1.3	2.2	-1.2	0.2	-1.2	1.3	-0.9	-1.5	1.4
Liver weight, right	0.6	1.0	2.9	-0.6	1.7	-0.4	0.4	-1.6	0.4	-0.9
Locomotor activity	0.2	0.4	1.1	0.2	-1.0	0.1	-0.1	0.5	-0.5	1.0
Locomotor testing distance	0.4	0.7	2.3	0.7	-1.5	0.6	-0.6	0.9	-0.0	0.9
Locomotor testing rearing	0.7	1.1	2.2	1.5	-1.0	1.4	-1.4	0.8	-0.3	-0.3
Locomotion in novel chamber	0.2	0.3	0.7	-0.0	-0.7	-0.0	-0.0	0.8	0.8	0.2
Locomotion in novel chamber post-restriction	1.2	1.5	4.6	0.5	1.9	0.6	-0.6	-1.0	0.1	-2.1
Fecal boli incidents, locomotor time 1	0.2	0.2	0.9	0.3	-0.9	0.2	-0.2	0.6	0.6	0.2
Change in fecal boli incidents, locomotor task	1.2	1.1	4.6	-0.3	-0.7	-0.5	0.6	-0.1	-2.1	1.4
Time >=10cm from walls, locomotor time 1	2.3	2.4	3.5	1.7	0.3	1.8	-1.9	1.1	1.4	-1.9
Bouts of movement, locomotor time 1	0.7	0.8	2.1	-0.4	-1.3	-0.5	0.5	0.9	-0.3	1.4
Total resting periods, locomotor time 1	0.8	0.9	2.5	-0.5	-1.4	-0.6	0.6	0.7	-0.5	1.6
Rest time, locomotor task time 1	0.2	0.3	0.5	-0.3	-0.2	-0.4	0.5	-0.7	-0.7	0.6
Distance moved, locomotor task time 1	0.3	0.3	0.6	0.5	0.5	0.6	-0.6	0.3	0.4	-0.8
Vertical activity count, locomotor time 1	0.6	0.6	1.1	0.6	0.6	0.8	-0.8	0.4	1.0	-1.1
Time >=10cm from walls, locomotor time 2	0.3	0.3	1.4	-0.6	0.1	-0.5	0.5	0.2	1.2	0.2
Bouts of movement, locomotor time 2	0.6	0.6	1.6	0.1	-1.3	0.1	-0.1	1.2	0.8	0.8
Total resting periods, locomotor time 2	0.7	0.7	1.6	0.5	-1.2	0.5	-0.5	1.3	1.0	0.3
Rest time, locomotor task time 2	0.7	0.8	1.7	1.3	-0.3	1.2	-1.2	0.0	-0.5	-0.8
Distance moved, locomotor task time 2	0.5	0.6	1.1	-1.0	0.0	-0.9	0.9	0.1	0.6	0.8
Vertical activity count, locomotor time 2	0.8	0.9	3.3	-1.0	-0.1	-0.8	0.7	0.8	1.8	0.3
Light reinforcement 1	1.0	1.9	3.3	1.5	0.8	1.7	-1.7	0.4	1.1	-1.8
Light reinforcement 2	0.5	0.7	2.1	0.2	1.4	0.5	-0.5	-0.5	0.6	-1.4
Bone: marrow area	0.4	1.0	1.3	1.0	-0.3	1.1	-1.1	0.9	1.0	-1.1
Bone: maximum diameter	1.7	3.2	6.8	-2.6	1.6	-2.3	2.2	-1.3	0.9	-0.6
Bone: maximum force	6.3	10.9	22.6	-4.8	3.3	-4.1	4.0	-2.3	1.9	-0.8
Bone: maximum moment	6.7	11.6	23.3	-4.8	3.6	-4.2	4.1	-2.7	1.5	-0.9
Mean time between licks in bursts	0.6	0.8	2.7	0.1	-1.6	-0.0	-0.0	1.3	0.4	1.0
Mean num. licks in bursts	0.9	1.1	4.1	0.7	0.8	0.6	-0.5	-1.4	-2.0	-0.2
Cd content in liver	1.0	1.1	2.2	-0.8	-1.5	-0.9	0.8	1.3	0.5	1.2
Co content in liver	0.0	0.1	0.3	0.1	-0.5	0.1	-0.1	0.2	0.1	-0.0
Cu content in liver	0.9	1.1	2.8	-0.8	0.8	-0.8	0.9	-1.7	-1.3	0.4
Fe content in liver	0.7	0.8	1.6	1.1	-1.3	1.0	-1.0	0.9	-0.1	0.4
K content in liver	1.1	1.0	4.2	0.1	1.0	0.3	-0.4	-0.3	1.3	-2.0
Mg content in liver	1.7	1.7	4.0	1.0	-0.3	1.1	-1.2	1.1	2.0	-1.7
Mn content in liver	1.0	1.1	2.6	-1.6	0.6	-1.5	1.4	-0.5	0.4	-0.0
Na content in liver	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.1	-0.0	0.0
Rb content in liver	0.5	0.6	2.3	-0.1	0.8	0.1	-0.1	0.1	1.5	-1.2
Se content in liver	0.9	1.2	2.2	1.5	0.5	1.5	-1.4	-0.2	-0.3	-1.1
Sr content in liver	1.7	1.6	4.8	-1.0	0.3	-1.1	1.2	-1.2	-2.2	1.0
Zn content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	-0.0	-0.2
Bone: minimum diameter	2.0	3.7	6.3	-2.2	2.5	-1.9	1.9	-2.4	0.4	-1.2
Time in familiar zone, hab. session 1	0.4	0.4	0.6	-0.8	0.2	-0.8	0.8	-0.3	-0.4	0.6
Time in novel zone, hab. session 1	0.4	0.4	0.8	0.9	-0.1	0.9	-0.8	0.3	0.2	-0.4
Total zone transitions, hab. session 1	0.3	0.4	0.8	-0.3	-0.8	-0.3	0.3	0.9	0.8	0.6
Total locomotion distance, hab. session 1	0.2	0.3	1.4	0.1	-0.1	0.1	-0.2	0.5	1.2	-0.3
Locomotion velocity, hab. session 1	0.2	0.3	1.6	-0.0	-0.1	0.1	-0.1	0.5	1.3	-0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.4	-0.6	0.4	-0.4	0.6	0.4	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.5	-0.1	-0.5	0.5	0.2	0.1	0.5
Total zone transitions, hab. session 2	1.2	1.5	6.4	-0.0	-0.9	0.1	-0.2	1.8	2.5	-0.5
Total locomotion distance, hab. session 2	1.4	1.9	6.7	0.9	-0.1	1.0	-1.1	1.2	2.6	-1.4
Locomotion velocity, hab. session 2	1.3	1.7	6.6	0.7	0.2	0.8	-0.9	1.0	2.6	-1.5
Novel to familiar place preference ratio	2.1	2.2	4.8	-1.3	2.1	-1.2	1.3	-2.2	-1.1	-0.3
Novelty place preference	2.2	2.2	4.8	-1.4	2.1	-1.3	1.3	-2.2	-1.1	-0.2
Time in novel zone, NPP test	1.6	1.7	3.5	-1.2	1.8	-1.1	1.1	-1.9	-0.9	-0.2
Total zone transitions, NPP test	2.2	3.1	7.7	1.4	-1.4	1.5	-1.5	2.3	2.8	-0.7
Total locomotion distance, NPP test	2.8	3.9	9.2	1.9	-0.7	2.0	-2.1	1.8	3.0	-1.4
Locomotion velocity, NPP test	1.9	2.7	6.8	1.6	-0.3	1.7	-1.7	1.4	2.6	-1.3
Intraocular pressure	0.7	0.9	2.9	0.8	0.8	0.9	-0.9	-0.3	0.5	-1.7
Delta distance traveled before/after self-admin	2.6	2.8	5.0	2.2	-1.0	2.2	-2.2	1.6	0.3	-1.2
Delta ambulatory time before/after self-admin	3.2	3.6	6.4	2.5	-1.5	2.4	-2.4	1.9	0.3	-1.0
Parametrial fat weight	0.6	1.2	3.4	0.5	1.8	0.6	-0.6	-1.2	0.2	-1.6
Pavlov. Cond. lever latency	1.2	1.6	5.1	0.3	-1.4	0.3	-0.4	1.9	2.3	-0.0
Pavlov. Cond. magazine entry latency	1.8	2.4	6.3	-0.7	2.2	-0.6	0.7	-2.5	-1.9	-0.6
Pavlov. Cond. change in total contacts	1.3	1.4	4.5	-0.6	0.8	-0.7	0.7	-1.7	-2.1	0.7
Pavlov. Cond. index score	1.7	2.2	5.7	-0.4	2.3	-0.3	0.4	-2.4	-1.7	-1.0
Pavlov. Cond. latency score	1.6	2.1	5.5	-0.3	2.1	-0.3	0.3	-2.3	-2.0	-0.7
Pavlov. Cond. lever contacts	0.6	0.7	2.1	0.3	1.0	0.3	-0.2	-1.3	-1.4	-0.4
Pavlov. Cond. magazine entry number	2.5	3.1	7.5	1.0	-2.2	1.0	-1.1	2.7	2.5	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.8	0.5	0.2	0.6	-0.7	0.5	1.4	-1.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	6.0	-0.8	2.3	-0.6	0.7	-2.4	-1.6	-0.9
Pavlov. Cond. response bias	1.9	2.3	6.0	-0.7	2.0	-0.7	0.8	-2.4	-2.2	-0.3
Pavlov. Cond. lever latency	0.6	0.8	1.9	-0.8	-0.5	-0.9	1.0	-0.3	-0.9	1.4
Pavlov. Cond. magazine entry latency	1.6	1.9	3.4	1.4	-1.8	1.3	-1.3	1.9	1.1	0.1
Pavlov. Cond. change in total contacts	0.5	0.7	1.2	0.9	-0.7	0.9	-0.9	1.1	0.8	-0.3
Pavlov. Cond. index score	0.7	0.8	1.3	1.1	-0.6	1.1	-1.1	0.9	0.8	-0.5
Pavlov. Cond. latency score	0.8	1.0	1.5	1.2	-0.6	1.2	-1.2	1.0	0.9	-0.6
Pavlov. Cond. lever contacts	0.9	1.3	3.1	1.1	0.6	1.2	-1.2	0.4	1.0	-1.8
Pavlov. Cond. magazine entry number	1.6	2.0	2.9	-1.6	1.6	-1.5	1.5	-1.7	-1.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.5	-0.5	1.6	-0.4	0.3	-0.8	0.5	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	1.3	-0.8	1.2	-1.2	1.0	0.7	-0.4
Pavlov. Cond. response bias	0.6	0.9	1.3	1.1	-0.1	1.1	-1.1	0.8	0.9	-1.0
Time in closed arm before self-admin	0.8	0.9	1.6	-1.2	0.2	-1.3	1.3	-0.2	-0.8	0.9
Time in closed arm after self-admin	1.1	1.1	1.9	-1.1	-0.2	-1.2	1.2	-0.5	-1.1	1.4
Time in open arm before self-admin	0.3	0.3	0.5	0.6	-0.7	0.6	-0.6	0.1	0.6	-0.2
Time in open arm after self-admin	0.2	0.2	0.4	0.0	-0.6	0.1	-0.1	0.6	0.7	0.1
Bone: periosteal estimation	1.8	3.7	7.1	-2.7	1.9	-2.3	2.2	-1.3	1.5	-1.0
Bone: periosteal perimeter	3.5	5.9	10.1	-3.2	2.7	-2.9	2.8	-2.7	-0.5	-0.3
Bone: post-yield work	0.2	0.3	1.3	-0.2	-0.3	-0.1	0.1	0.8	1.1	-0.2
Progressive ratio test 1 active lever presses	0.9	0.9	2.9	0.9	1.0	1.0	-0.9	-0.3	0.1	-1.7
Progressive ratio test 1 breakpoint	1.1	1.1	3.2	1.0	1.2	1.0	-1.0	-0.2	0.1	-1.8
Progressive ratio test 1 inactive lever presses	0.7	0.8	2.8	-0.1	1.5	0.1	-0.1	-0.4	0.6	-1.7
Progressive ratio test 2 active lever presses	0.4	0.4	1.1	0.5	0.7	0.5	-0.5	-0.6	0.1	-1.0
Progressive ratio test 2 breakpoint	0.6	0.6	1.7	0.8	0.7	0.8	-0.8	-0.4	0.5	-1.3
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.6	-0.3	0.8	-0.3	0.3	-0.8	-0.1	-0.3
Incentive Sensitization - Responses	0.4	0.4	0.8	0.7	0.6	0.7	-0.7	-0.5	0.1	-0.9
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.7	0.5	0.6	-0.6	-0.5	-0.0	-0.7
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.1	-0.6	1.2	-0.6	0.7	-1.4	-1.2	0.3
Progressive ratio	0.2	0.2	0.6	-0.2	-0.8	-0.3	0.3	0.2	0.2	0.8
Food seeking constrained by brief footshock	0.2	0.2	0.8	0.2	-0.1	0.1	-0.0	-0.7	-0.9	0.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.5	0.7	0.4	0.7	-0.7	-0.2	-0.0	-0.6
Retroperitoneal fat weight	1.6	5.4	13.6	1.0	3.7	1.4	-1.3	-2.4	0.5	-3.6
Reaction time number correct	2.4	3.5	9.1	1.1	-0.9	1.3	-1.4	2.6	3.0	-1.8
Reaction time mean minus median	0.4	0.5	2.7	0.4	-0.0	0.3	-0.2	-0.6	-1.7	0.4
Reaction time mean minus median AUC	0.1	0.2	0.7	0.4	0.0	0.4	-0.4	-0.3	-0.8	-0.0
Reaction time num false alarms	0.1	0.1	0.3	-0.0	-0.5	-0.1	0.1	0.5	-0.0	0.3
Reaction time num false alarms AUC	0.2	0.3	1.0	0.3	-1.0	0.3	-0.3	0.9	0.2	0.4
Reaction time trials correct on left	2.4	3.5	9.1	1.1	-0.9	1.3	-1.4	2.6	3.0	-1.8
Reaction time trials on left	2.6	3.7	9.4	1.1	-0.9	1.3	-1.5	2.6	3.1	-1.8
Reaction time mean	0.1	0.2	0.4	0.4	0.5	0.5	-0.5	-0.1	-0.1	-0.6
Reaction time mean AUC	0.3	0.4	0.6	0.7	0.2	0.8	-0.8	0.2	0.3	-0.8
Median of all reaction times	0.1	0.2	0.5	0.3	0.4	0.3	-0.3	0.1	0.5	-0.7
Reaction time omissions	0.4	0.6	1.1	1.0	-0.1	1.0	-1.0	0.2	0.2	-0.9
Reaction time false alarm rate	0.4	0.6	1.9	-0.2	-0.4	-0.4	0.4	-0.4	-1.4	1.3
Reaction time premature initiation rate	0.3	0.3	1.5	0.1	-1.2	-0.0	-0.0	0.5	-0.0	0.8
Reaction time premature initiations	1.0	1.4	3.3	0.8	-1.5	0.8	-0.8	1.8	1.6	-0.3
Std. dev. reaction times	0.2	0.3	0.5	0.7	-0.7	0.6	-0.6	0.6	-0.6	0.1
Reaction time trials completed	2.6	3.7	9.4	1.1	-0.9	1.3	-1.5	2.6	3.1	-1.8
Reaction time trials AUC	2.4	3.5	9.4	1.0	-0.8	1.3	-1.4	2.6	3.1	-1.8
Run reversals in cocaine runway, females	0.8	0.8	2.2	0.8	-0.9	0.8	-0.8	1.5	0.6	-0.1
Run reversals in cocaine runway, males	1.4	1.4	4.8	-0.2	1.5	-0.3	0.3	-2.2	-1.4	-0.3
Latency to leave start box in cocaine runway	0.5	0.5	0.9	1.0	-0.7	0.9	-0.9	0.8	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.9	1.0	1.2	1.1	-1.0	1.1	-1.1	1.0	1.0	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.6	0.4	0.5	-0.5	-0.0	-0.2	-0.4
Std. dev. time between licks in bursts	2.1	2.5	8.2	1.0	-0.1	1.2	-1.3	1.5	2.9	-1.7
Total sessions with >9 infusions	0.2	0.2	0.9	0.0	-0.6	0.0	-0.0	0.9	0.6	0.2
Short access day 1 total inactive lever presses	0.5	0.5	1.4	0.5	-0.6	0.6	-0.6	0.9	1.2	-0.4
Short access day 10 total inactive lever presses	1.2	1.4	4.8	-0.7	2.2	-0.6	0.6	-1.6	0.1	-1.1
Short access day 1 total infusions	0.7	0.7	2.0	-0.3	-1.4	-0.4	0.4	1.2	-0.1	1.2
Short access day 10 total infusions	0.4	0.5	1.0	0.5	0.9	0.5	-0.5	-0.6	-0.5	-1.0
Short access total infusions	0.1	0.1	0.3	0.3	0.0	0.3	-0.3	0.5	0.1	-0.3
Short access day 1 locomotion	0.6	0.7	1.3	-1.0	-0.5	-1.0	1.0	0.3	-0.5	1.1
Short access day 10 total locomotion	0.7	0.8	1.3	-0.9	0.1	-1.0	1.0	-0.9	-0.8	1.1
Short access total locomotion	0.5	0.6	1.1	-0.9	-0.4	-1.0	0.9	0.0	-0.3	1.0
One hour access (0.3 mA shock)	1.0	1.2	2.7	1.0	1.2	1.1	-1.1	-0.6	0.6	-1.6
Compulsive drug intake	0.1	0.1	0.3	-0.3	0.5	-0.2	0.2	-0.3	0.5	-0.1
One hour access (shock baseline)	0.8	1.0	1.6	1.3	0.2	1.3	-1.3	0.2	0.6	-1.2
Social response proportion	0.4	0.4	0.9	-0.3	-0.8	-0.3	0.3	0.8	1.0	0.6
Social responses	0.3	0.4	2.1	-0.1	-0.7	-0.1	0.1	0.6	1.4	0.4
Social time	0.2	0.3	0.7	-0.5	-0.5	-0.5	0.4	0.5	0.8	0.6
Soleus weight	0.5	1.4	4.4	0.3	1.9	0.5	-0.5	-1.0	0.5	-2.1
Bone: stiffness	3.4	5.3	12.6	-3.6	1.1	-3.2	3.1	-0.6	1.8	0.4
Tibialis anterior weight	0.5	1.7	3.1	1.8	-0.1	1.7	-1.7	0.7	0.9	-1.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.5	0.2	0.2	0.3	-0.3	0.2	0.0	-0.7
Time to tail flick, vehicle, after self-admin	1.1	1.2	3.0	-0.6	-1.7	-0.7	0.6	1.2	0.5	1.5
Time to tail flick, test, before self-admin	0.3	0.2	0.7	0.4	0.4	0.3	-0.3	-0.6	-0.3	-0.9
Time to tail flick, test, after self-admin	0.2	0.2	0.5	-0.4	-0.7	-0.4	0.4	-0.1	-0.1	0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	0.6	-0.9	0.5	-0.6	0.9	0.8	0.2
Delta time to tail flick, test, before/after SA	1.9	1.7	3.6	-1.6	-0.6	-1.6	1.6	-0.0	-0.4	1.9
Tibia length	6.8	19.3	33.5	-5.4	5.8	-4.7	4.7	-5.1	-0.5	-1.3
Ambulatory time before self-admin	1.6	1.7	3.7	-1.2	1.9	-1.1	1.1	-1.9	-0.9	-0.1
Ambulatory time after self-admin	0.7	0.8	1.4	1.2	0.5	1.2	-1.2	0.0	-0.4	-1.0
Bone: tissue strength	1.4	1.3	2.6	-1.5	0.8	-1.2	1.1	-0.2	1.6	-1.0
Total heroin consumption	3.8	4.4	7.9	-2.8	0.4	-2.8	2.8	-1.5	-1.1	2.1
Bone: trabecular number	0.0	0.0	0.1	-0.2	0.0	-0.1	0.1	0.1	0.1	-0.3
Bone: trabecular spacing	2.2	2.9	5.5	1.8	-0.4	1.9	-1.9	1.4	2.4	-1.4
Bone: trabecular thickness	2.0	2.4	3.5	-1.8	1.2	-1.8	1.8	-1.9	-1.5	0.6
Bone: trabecular tissue density	0.4	0.5	1.2	0.5	-1.1	0.4	-0.4	0.8	-0.2	1.0
Water consumed over 24 hours	0.4	0.5	2.3	-0.3	0.1	-0.4	0.5	-0.7	-1.5	0.3
Number of responses in last shaping day	0.6	0.7	1.3	-1.1	0.7	-1.0	0.9	-0.3	1.0	-0.2