Hub : Genes

Dok2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Dok2 0.07 0.05 7.6e-06 0.04 0.04 0.04 0.04 2.8e-05 2.8e-05 5.7e-05 4.8e-05
2 Brain mRNA stability Dok2 0.04 0.03 6.3e-03 0.02 0.02 0.01 0.02 3.1e-03 7.2e-03 1.4e-02 6.0e-03
3 NAcc intron excision ratio chr15_52237221_52247028 0.04 0.03 4.3e-05 0.02 0.02 0.02 0.02 3.7e-04 2.4e-04 5.2e-04 3.8e-04
4 Adipose alternative TSS XM_063274143.1 0.06 0.04 1.8e-05 0.02 0.04 0.04 0.04 4.0e-03 4.4e-05 3.0e-05 5.2e-05
5 Adipose alternative TSS NM_001106048.2 0.06 0.04 1.7e-05 0.02 0.04 0.04 0.04 6.2e-03 3.7e-05 2.4e-05 5.1e-05
6 Adipose alternative TSS XM_063274143.1 0.05 0.03 9.4e-05 0.01 0.03 0.02 0.03 1.9e-02 1.9e-04 2.5e-03 3.2e-04
7 Adipose isoform ratio XM_063274143.1 0.04 0.03 4.4e-04 0 0.02 0.01 0.01 8.4e-02 1.8e-03 1.1e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.50.82.2-0.10.11.50.9-0.90.91.0
Area under the delay curve0.10.20.30.4-0.4-0.1-0.50.5-0.4-0.4
BMI with tail0.20.72.7-1.11.1-1.6-0.00.0-0.1-0.3
BMI without tail0.51.62.8-1.71.7-0.61.2-1.21.00.9
Body weight0.31.53.10.4-0.4-1.8-1.21.2-1.4-1.4
Weight adjusted by age1.21.82.31.0-1.0-1.3-1.51.5-1.5-1.5
Bone surface0.20.41.70.7-0.71.30.0-0.10.20.3
Bone volume0.20.41.70.6-0.61.30.2-0.20.40.5
Breakpoint value in progressive ratio session0.10.10.10.3-0.3-0.2-0.40.4-0.3-0.3
Number of licking bursts0.00.10.1-0.30.3-0.10.3-0.30.20.2
Context. condit. distance diff. score6.47.812.4-3.53.50.12.8-2.82.72.5
Locomotion velocity, session 10.20.20.30.5-0.5-0.3-0.50.5-0.5-0.5
Locomotion distance, session 11.11.43.21.8-1.80.7-0.80.8-0.9-0.8
Locomotion velocity, session 20.40.51.11.1-1.10.5-0.50.5-0.5-0.4
Locomotion distance, session 22.43.37.32.7-2.71.1-1.41.4-1.5-1.3
Locomotion velocity, session 30.70.81.9-1.41.4-1.20.4-0.30.40.2
Locomotion distance, session 30.80.91.7-1.31.3-0.20.9-0.90.90.8
Stereotopy head waving bouts, day 30.40.50.70.5-0.5-0.8-0.70.7-0.8-0.8
Stereotopy head waving duration, day 31.72.02.70.9-0.9-1.6-1.51.5-1.6-1.6
Locomotion velocity, session 710.711.714.7-3.83.81.13.6-3.63.73.5
Locomotion distance, session 76.88.69.9-3.13.11.33.1-3.13.13.1
Stereotopy head waving bouts, day 71.71.92.41.2-1.2-1.1-1.61.6-1.5-1.5
Stereotopy head waving duration, day 71.82.12.81.0-1.0-1.5-1.71.7-1.6-1.6
Locomotion velocity, session 80.60.71.4-1.21.2-0.10.7-0.70.70.7
Locomotion distance, session 80.60.81.2-0.60.61.01.1-1.11.01.0
Degree of sensitization distance5.05.16.4-2.02.01.72.5-2.52.52.5
Degree of sensitization stereotypy0.90.91.20.6-0.6-1.0-1.11.1-1.1-1.1
Conditioned locomotion0.60.71.3-1.21.2-0.10.7-0.70.80.7
Cocaine response after cond. corrected1.31.63.8-2.02.0-1.10.8-0.80.80.6
Cocaine response after cond. not corrected0.60.71.8-1.31.3-0.70.5-0.50.50.4
Cocaine response before conditioning1.11.33.01.7-1.70.9-0.70.7-0.7-0.6
Saline control response0.60.71.71.3-1.30.8-0.60.6-0.5-0.4
Bone: connectivity density1.32.03.5-0.60.61.91.5-1.51.51.6
Bone: cortical apparent density1.92.64.7-2.22.2-0.41.5-1.51.51.4
Bone: cortical area0.30.51.01.0-1.00.4-0.70.6-0.5-0.4
Bone: cortical porosity2.42.63.01.7-1.7-0.6-1.71.7-1.7-1.7
Bone: cortical porosity2.42.63.61.9-1.9-0.3-1.71.7-1.7-1.6
Bone: cortical thickness0.00.00.10.2-0.20.3-0.20.2-0.1-0.0
Bone: cortical thickness0.91.12.1-1.41.4-0.31.0-1.00.90.8
Bone: cortical tissue density2.22.95.4-2.32.3-0.41.6-1.61.61.5
Condit. Reinf. active minus inactive responses0.70.81.10.9-0.9-0.4-0.90.9-1.0-1.0
Condit. Reinf. active-inactive response ratio0.70.82.3-0.20.2-1.5-0.80.8-0.9-1.0
Condit. Reinf. active responses0.91.12.21.5-1.50.5-0.90.9-0.9-0.8
Condit. Reinf. inactive responses1.51.85.51.9-1.92.3-0.10.00.00.2
Incentive salience index mean2.02.43.21.8-1.8-0.3-1.61.6-1.7-1.6
Condit. Reinf. lever presses2.02.84.82.2-2.20.1-1.61.6-1.7-1.5
Condit. Reinf. active minus inactive responses0.20.20.5-0.20.20.70.5-0.50.50.6
Condit. Reinf. active-inactive response ratio0.10.10.3-0.60.6-0.40.2-0.10.20.1
Condit. Reinf. active responses0.40.51.3-0.10.11.20.7-0.70.80.8
Condit. Reinf. inactive responses0.70.93.00.3-0.31.70.9-0.90.91.0
Condit. Reinf. lever presses0.60.92.11.4-1.40.8-0.50.5-0.6-0.5
Condit. Reinf. lever reinforcers received0.20.31.10.1-0.11.00.5-0.60.60.6
Conditioned reinforcement - actives1.01.82.2-1.11.11.11.5-1.51.51.5
Conditioned reinforcement - inactives1.11.66.20.7-0.72.50.9-0.91.01.1
Conditioned locomotion0.20.20.3-0.40.40.40.6-0.60.50.6
Patch foraging indifference point 0 sec1.83.37.42.7-2.72.6-0.80.7-0.4-0.2
Patch foraging indifference point AUC0.30.41.1-1.01.0-0.90.2-0.20.20.1
Delay disc. indifference point, 0s delay0.60.71.51.2-1.21.0-0.50.5-0.3-0.2
Delay disc. indifference point, 16s delay0.10.10.3-0.20.20.50.3-0.30.40.4
Delay disc. indifference point, 2s delay1.92.22.81.3-1.3-1.0-1.71.7-1.6-1.6
Delay disc. indifference point, 24s delay0.20.20.6-0.80.8-0.60.2-0.20.20.1
Delay disc. indifference point, 4s delay0.80.81.90.1-0.1-1.4-1.01.0-0.9-1.0
Delay disc. indifference point, 8s delay0.00.00.10.2-0.20.3-0.10.1-0.00.0
Indifference point function ln k0.40.71.51.2-1.20.5-0.60.6-0.7-0.6
Indifference point function log k0.40.71.51.2-1.20.5-0.60.6-0.7-0.6
Patch foraging total patch changes 0 sec1.83.37.72.8-2.82.3-1.00.9-0.6-0.4
Patch foraging total patch changes 12 sec0.81.02.31.5-1.51.4-0.60.6-0.3-0.2
Patch foraging total patch changes 18 sec0.50.72.70.2-0.21.60.6-0.60.80.9
Patch foraging total patch changes 24 sec1.11.93.51.9-1.90.5-1.31.3-1.2-1.0
Patch foraging total patch changes 6 sec0.10.10.50.4-0.40.7-0.00.00.10.2
Patch foraging time to switch 0 sec0.40.91.1-0.60.61.01.0-1.01.01.1
Patch foraging water rate 0 sec0.51.11.31.1-1.1-0.4-1.11.1-1.1-1.1
Patch foraging water rate 12 sec0.51.11.50.9-0.9-0.7-1.21.2-1.2-1.2
Patch foraging water rate 18 sec1.11.74.70.1-0.1-2.2-1.21.3-1.4-1.5
Patch foraging water rate 24 sec0.20.30.7-0.80.8-0.80.3-0.30.20.1
Patch foraging water rate 6 sec2.84.15.21.9-1.9-1.2-2.32.3-2.2-2.2
Seeking ratio, delayed vs. immediate footshock0.30.41.40.5-0.51.20.4-0.40.40.5
Distance traveled before self-admin2.22.83.61.9-1.9-0.5-1.81.8-1.7-1.7
Distance traveled after self-admin1.01.23.4-0.00.0-1.8-1.11.1-1.1-1.2
Extensor digitorum longus weight6.625.948.71.9-1.9-7.0-5.55.5-5.6-5.9
Bone: elastic displacement0.40.41.21.0-1.01.1-0.10.1-0.1-0.0
Bone: elastic work1.51.94.52.1-2.11.2-0.90.9-0.9-0.7
Bone: endosteal estimation0.40.81.31.1-1.1-0.1-1.00.9-0.9-0.8
Bone: endosteal perimeter0.71.42.51.6-1.60.1-1.21.2-1.1-1.0
Epididymis fat weight0.51.72.5-0.70.71.61.6-1.61.31.4
Delta time in closed arm before/after self-admin1.41.35.00.7-0.72.20.8-0.80.81.0
Delta time in open arm before/after self-admin0.00.00.1-0.30.3-0.4-0.00.0-0.0-0.0
Diff in mean of infusions in LGA sessions0.50.70.90.5-0.5-0.9-0.90.9-0.9-0.9
Delay discount exponential model param0.30.40.6-0.40.40.50.8-0.80.70.7
Extinction: sum of active levers before priming0.91.02.6-0.10.11.61.0-1.01.11.1
Active lever presses in extinction session 60.90.91.1-0.90.90.61.0-1.01.01.0
Bone: final force0.30.40.60.8-0.8-0.2-0.70.7-0.6-0.6
Bone: final moment0.50.91.51.2-1.20.0-0.90.9-0.8-0.8
Food consumed during 24 hour testing period0.40.51.31.1-1.11.0-0.20.2-0.3-0.2
Glucose0.50.71.5-1.21.2-0.40.7-0.60.70.6
Heart weight0.10.20.90.5-0.51.00.0-0.00.20.3
Delay discount hyperbolic model param0.40.50.7-0.50.50.60.9-0.90.80.8
Intermittent access intake day 1-15 change1.02.13.2-0.80.81.81.6-1.61.61.7
Intermittent access intake escalation0.91.83.7-0.40.41.91.4-1.41.41.5
Intermittent access intake escalation 21.51.72.0-1.11.11.11.4-1.41.41.4
Intermitt. access day 1 inactive lever presses0.10.20.4-0.70.7-0.00.4-0.40.40.4
Intermitt. access day 15 inactive lever presses0.00.10.10.4-0.40.3-0.10.1-0.1-0.0
Intermitt. access escalation Index0.10.10.20.4-0.4-0.1-0.40.4-0.4-0.4
Intermittent access day 1 total infusions0.00.00.00.2-0.20.1-0.10.1-0.1-0.1
Intermittent access day 15 total infusions0.71.03.00.0-0.01.70.9-0.91.01.1
Intermittent access terminal intake (last 3 days)0.91.21.5-0.80.81.11.2-1.21.21.2
Intermittent access total infusions0.91.11.4-0.70.71.11.2-1.21.11.2
Intermittent access day 1 locomotion0.30.40.90.9-0.90.4-0.50.5-0.5-0.4
Intermittent access day 15 total locomotion0.20.40.5-0.50.50.60.7-0.70.70.7
Intermittent access total locomotion0.00.10.20.0-0.00.40.2-0.20.30.3
Intermittent access standard deviation0.10.10.40.1-0.10.70.3-0.30.30.3
Left kidney weight0.31.21.91.4-1.4-0.1-1.01.0-1.1-1.1
Right kidney weight0.73.35.82.4-2.40.3-1.81.8-1.6-1.5
Cocaine induced anxiety1.92.75.32.3-2.30.6-1.51.5-1.4-1.2
Post-drug Anxiety1.31.43.31.8-1.81.5-0.60.5-0.4-0.3
Baseline Anxiety1.01.21.4-1.21.20.41.2-1.21.11.1
Tail length0.20.83.11.1-1.11.80.2-0.20.20.4
Length with tail0.52.33.82.0-2.00.0-1.51.5-1.5-1.4
Length without tail2.06.38.21.8-1.8-2.4-2.82.8-2.8-2.9
Times rat made contact with spout0.50.60.8-0.60.60.70.9-0.90.80.8
Lifetime Intake0.60.70.9-0.60.60.91.0-1.00.91.0
Liver weight, left2.94.85.92.3-2.3-1.2-2.22.2-2.4-2.4
Liver weight, right0.20.31.0-0.10.1-1.0-0.30.3-0.5-0.6
Locomotor activity8.012.519.04.4-4.4-0.5-3.63.6-3.6-3.4
Locomotor testing distance4.27.616.04.0-4.01.3-2.32.3-2.2-2.0
Locomotor testing rearing4.79.520.64.5-4.51.7-2.52.4-2.4-2.1
Locomotion in novel chamber0.20.20.90.4-0.40.90.2-0.30.30.4
Locomotion in novel chamber post-restriction0.30.61.10.3-0.3-1.1-0.80.8-0.8-0.8
Fecal boli incidents, locomotor time 10.91.41.81.0-1.0-0.9-1.31.3-1.3-1.3
Change in fecal boli incidents, locomotor task0.20.20.5-0.60.6-0.70.1-0.10.0-0.0
Time >=10cm from walls, locomotor time 10.40.41.50.1-0.11.20.6-0.60.60.7
Bouts of movement, locomotor time 11.71.96.1-0.10.1-2.5-1.31.3-1.3-1.5
Total resting periods, locomotor time 11.51.76.5-0.60.6-2.5-1.01.0-1.1-1.2
Rest time, locomotor task time 10.60.83.1-0.50.5-1.7-0.60.6-0.7-0.8
Distance moved, locomotor task time 11.11.73.6-0.40.41.91.4-1.41.41.5
Vertical activity count, locomotor time 10.40.92.21.4-1.41.5-0.20.2-0.2-0.0
Time >=10cm from walls, locomotor time 20.10.20.50.0-0.0-0.7-0.40.4-0.5-0.5
Bouts of movement, locomotor time 21.21.96.5-0.50.5-2.5-1.21.2-1.2-1.4
Total resting periods, locomotor time 21.22.07.1-0.50.5-2.7-1.31.3-1.2-1.4
Rest time, locomotor task time 20.60.82.3-1.21.2-1.50.0-0.0-0.0-0.2
Distance moved, locomotor task time 21.11.35.30.9-0.92.30.6-0.70.70.9
Vertical activity count, locomotor time 20.81.22.91.7-1.71.2-0.60.5-0.5-0.3
Light reinforcement 11.84.56.0-1.51.51.92.4-2.42.32.4
Light reinforcement 23.45.27.1-2.72.70.42.4-2.42.32.2
Bone: marrow area0.30.71.31.1-1.10.0-0.90.9-0.8-0.7
Bone: maximum diameter0.20.50.70.5-0.5-0.6-0.90.9-0.7-0.7
Bone: maximum force0.91.62.31.5-1.5-0.2-1.41.4-1.2-1.2
Bone: maximum moment1.32.33.82.0-2.00.1-1.61.6-1.4-1.3
Mean time between licks in bursts0.51.13.50.2-0.21.91.1-1.10.91.0
Mean num. licks in bursts0.10.20.3-0.20.20.60.5-0.50.50.5
Cd content in liver1.82.02.51.4-1.4-0.8-1.61.6-1.5-1.5
Co content in liver1.82.07.2-0.50.5-2.7-1.31.3-1.2-1.4
Cu content in liver0.10.20.6-0.30.3-0.7-0.30.3-0.3-0.3
Fe content in liver0.60.82.1-0.10.11.40.8-0.81.01.0
K content in liver1.21.21.5-1.01.00.91.1-1.11.21.2
Mg content in liver1.81.92.5-0.80.81.51.5-1.51.51.6
Mn content in liver1.01.13.1-0.10.11.81.0-1.01.11.2
Na content in liver4.14.46.12.5-2.5-0.3-2.22.2-2.1-2.0
Rb content in liver0.50.61.2-1.11.1-0.20.7-0.70.70.7
Se content in liver2.22.66.22.5-2.51.9-0.80.8-0.8-0.6
Sr content in liver0.10.10.20.5-0.50.3-0.30.3-0.2-0.1
Zn content in liver0.40.51.11.1-1.10.8-0.50.5-0.4-0.3
Bone: minimum diameter1.12.03.31.8-1.80.1-1.51.5-1.3-1.2
Time in familiar zone, hab. session 10.10.10.3-0.50.5-0.30.2-0.20.20.2
Time in novel zone, hab. session 10.40.41.8-0.50.5-1.3-0.40.4-0.4-0.5
Total zone transitions, hab. session 10.81.11.81.3-1.3-0.0-1.01.0-1.0-1.0
Total locomotion distance, hab. session 10.91.32.81.7-1.70.6-0.90.9-0.9-0.8
Locomotion velocity, hab. session 11.72.45.52.4-2.41.1-1.11.1-1.1-0.9
Time in familiar zone, hab. session 21.11.23.5-1.51.5-1.90.0-0.00.0-0.2
Time in novel zone, hab. session 20.50.51.21.0-1.01.1-0.10.1-0.10.0
Total zone transitions, hab. session 23.44.35.92.4-2.4-0.7-2.02.0-2.2-2.1
Total locomotion distance, hab. session 21.31.83.01.7-1.7-0.1-1.21.2-1.3-1.2
Locomotion velocity, hab. session 22.33.04.82.2-2.2-0.3-1.71.7-1.8-1.7
Novel to familiar place preference ratio0.50.52.10.6-0.61.40.4-0.50.50.6
Novelty place preference0.40.41.60.6-0.61.30.4-0.40.40.5
Time in novel zone, NPP test0.20.20.90.6-0.60.90.2-0.20.20.2
Total zone transitions, NPP test0.81.12.81.7-1.71.0-0.50.5-0.6-0.5
Total locomotion distance, NPP test1.21.76.11.6-1.62.50.4-0.40.30.5
Locomotion velocity, NPP test1.11.65.91.5-1.52.40.4-0.40.30.5
Intraocular pressure0.20.41.00.1-0.11.00.7-0.70.50.5
Delta distance traveled before/after self-admin1.61.75.5-1.81.8-2.40.0-0.0-0.1-0.3
Delta ambulatory time before/after self-admin1.21.55.6-1.51.5-2.4-0.20.2-0.3-0.5
Parametrial fat weight0.81.94.1-0.40.42.01.4-1.51.51.6
Pavlov. Cond. lever latency0.40.51.0-1.01.0-0.40.5-0.50.60.5
Pavlov. Cond. magazine entry latency0.00.00.10.0-0.00.20.1-0.10.10.1
Pavlov. Cond. change in total contacts1.61.72.21.4-1.4-0.6-1.41.4-1.5-1.4
Pavlov. Cond. index score0.30.40.70.8-0.80.0-0.60.6-0.7-0.6
Pavlov. Cond. latency score0.30.40.80.9-0.90.2-0.60.6-0.6-0.6
Pavlov. Cond. lever contacts0.20.30.60.8-0.80.5-0.30.3-0.4-0.3
Pavlov. Cond. magazine entry number0.30.30.5-0.40.40.50.6-0.60.70.7
Pavlov. Cond. intertrial magazine entries0.81.02.31.5-1.50.7-0.70.7-0.6-0.5
Pavlov. Cond. lever-magazine prob. diff.0.50.60.80.9-0.9-0.1-0.70.7-0.8-0.8
Pavlov. Cond. response bias0.20.20.30.5-0.5-0.3-0.50.5-0.5-0.5
Pavlov. Cond. lever latency2.23.04.8-2.22.20.11.7-1.71.71.7
Pavlov. Cond. magazine entry latency0.60.71.71.3-1.30.6-0.60.5-0.6-0.5
Pavlov. Cond. change in total contacts1.82.93.51.8-1.8-0.9-1.81.8-1.9-1.8
Pavlov. Cond. index score2.12.84.42.1-2.1-0.2-1.61.6-1.7-1.6
Pavlov. Cond. latency score2.02.64.52.1-2.1-0.0-1.51.5-1.6-1.5
Pavlov. Cond. lever contacts2.02.74.82.2-2.20.1-1.51.5-1.6-1.5
Pavlov. Cond. magazine entry number0.30.41.0-1.01.0-0.40.4-0.40.50.4
Pavlov. Cond. intertrial magazine entries2.53.77.7-0.50.52.82.1-2.12.12.2
Pavlov. Cond. lever-magazine prob. diff.1.92.53.81.9-1.9-0.3-1.61.6-1.6-1.6
Pavlov. Cond. response bias2.12.95.02.2-2.20.1-1.61.6-1.7-1.6
Time in closed arm before self-admin0.50.72.6-0.60.6-1.6-0.50.5-0.5-0.7
Time in closed arm after self-admin0.00.00.0-0.10.1-0.1-0.00.0-0.1-0.1
Time in open arm before self-admin0.20.30.50.7-0.70.2-0.40.4-0.4-0.4
Time in open arm after self-admin0.10.10.20.5-0.50.3-0.20.2-0.1-0.1
Bone: periosteal estimation0.40.91.61.3-1.30.1-1.01.0-0.8-0.8
Bone: periosteal perimeter0.40.71.31.1-1.10.0-0.90.9-0.7-0.7
Bone: post-yield work0.50.70.8-0.90.90.20.9-0.90.90.9
Progressive ratio test 1 active lever presses0.50.61.5-1.21.2-0.70.6-0.60.50.4
Progressive ratio test 1 breakpoint0.50.71.6-1.31.3-0.80.6-0.50.50.4
Progressive ratio test 1 inactive lever presses0.91.31.7-1.01.00.91.3-1.31.31.3
Progressive ratio test 2 active lever presses0.40.50.9-0.90.9-0.10.7-0.70.70.6
Progressive ratio test 2 breakpoint0.20.30.5-0.70.7-0.00.5-0.50.50.4
Progressive ratio test 2 inactive lever presses0.20.30.4-0.40.40.60.6-0.60.60.6
Incentive Sensitization - Responses0.10.10.3-0.10.10.60.4-0.40.40.4
Incentive Sensitization - Breakpoint0.10.10.50.1-0.10.70.3-0.30.40.4
Sum of active levers in priming session hrs 5-60.60.60.9-0.90.9-0.00.8-0.80.80.7
Progressive ratio0.10.20.5-0.70.7-0.40.3-0.30.20.1
Food seeking constrained by brief footshock2.83.48.1-2.82.8-2.50.8-0.70.60.3
Seeking ratio, punishment vs. effort0.30.51.6-0.90.9-1.30.0-0.00.0-0.1
Retroperitoneal fat weight0.10.60.8-0.90.90.40.7-0.70.90.9
Reaction time number correct0.20.31.5-0.50.5-1.2-0.10.2-0.3-0.4
Reaction time mean minus median0.40.91.41.2-1.2-0.1-1.01.0-0.9-0.9
Reaction time mean minus median AUC0.10.30.40.6-0.6-0.1-0.50.5-0.6-0.6
Reaction time num false alarms0.30.40.60.8-0.8-0.2-0.50.5-0.7-0.7
Reaction time num false alarms AUC0.20.20.40.7-0.7-0.2-0.30.3-0.6-0.5
Reaction time trials correct on left0.20.31.5-0.50.5-1.2-0.10.2-0.3-0.4
Reaction time trials on left0.20.31.2-0.60.6-1.1-0.00.1-0.2-0.3
Reaction time mean0.20.40.50.7-0.7-0.3-0.60.6-0.7-0.7
Reaction time mean AUC0.50.70.90.9-0.9-0.4-0.90.9-0.9-0.9
Median of all reaction times0.10.10.20.4-0.4-0.3-0.30.3-0.4-0.4
Reaction time omissions1.01.42.4-0.40.41.51.3-1.41.31.4
Reaction time false alarm rate0.10.10.20.5-0.50.40.0-0.0-0.1-0.1
Reaction time premature initiation rate0.70.94.0-0.90.9-2.0-0.30.3-0.5-0.7
Reaction time premature initiations0.81.46.1-1.21.2-2.5-0.20.2-0.5-0.7
Std. dev. reaction times0.30.50.80.9-0.9-0.2-0.70.7-0.8-0.8
Reaction time trials completed0.20.31.2-0.60.6-1.1-0.00.1-0.2-0.3
Reaction time trials AUC0.10.31.1-0.50.5-1.0-0.00.1-0.2-0.3
Run reversals in cocaine runway, females1.41.43.2-0.30.31.81.3-1.31.21.3
Run reversals in cocaine runway, males1.21.21.60.7-0.7-1.3-1.21.2-1.2-1.3
Latency to leave start box in cocaine runway0.30.30.50.3-0.3-0.7-0.60.6-0.6-0.6
Latency to leave start box in cocaine runway, F0.91.01.40.6-0.6-1.2-1.11.1-1.1-1.2
Latency to leave start box in cocaine runway, M0.00.00.10.2-0.20.30.1-0.10.10.1
Std. dev. time between licks in bursts1.31.84.22.0-2.02.0-0.20.2-0.4-0.2
Total sessions with >9 infusions0.00.00.0-0.10.1-0.2-0.00.0-0.0-0.0
Short access day 1 total inactive lever presses0.20.30.70.8-0.80.6-0.30.3-0.2-0.2
Short access day 10 total inactive lever presses0.10.20.2-0.40.40.40.5-0.50.50.5
Short access day 1 total infusions0.20.20.5-0.70.7-0.40.3-0.30.30.2
Short access day 10 total infusions0.70.91.21.1-1.1-0.3-1.01.0-1.0-1.0
Short access total infusions0.00.10.10.3-0.3-0.1-0.30.3-0.3-0.3
Short access day 1 locomotion1.41.72.11.4-1.4-0.7-1.41.4-1.4-1.4
Short access day 10 total locomotion0.20.30.70.8-0.80.2-0.60.6-0.5-0.5
Short access total locomotion1.11.32.21.5-1.50.0-1.11.1-1.1-1.0
One hour access (0.3 mA shock)0.20.31.20.5-0.51.10.2-0.20.20.3
Compulsive drug intake0.50.61.51.2-1.21.1-0.30.2-0.2-0.1
One hour access (shock baseline)0.00.00.00.1-0.10.1-0.10.1-0.1-0.0
Social response proportion2.02.35.5-2.42.4-0.91.0-1.01.11.0
Social responses1.01.31.8-1.01.01.01.1-1.11.31.3
Social time0.50.71.51.2-1.21.1-0.50.4-0.3-0.2
Soleus weight0.41.34.4-0.10.1-2.1-0.90.9-1.1-1.3
Bone: stiffness0.61.01.40.8-0.8-0.9-1.21.2-1.0-1.1
Tibialis anterior weight5.017.125.22.2-2.2-5.0-4.64.6-4.6-4.8
Time to tail flick, vehicle, before self-admin0.80.81.1-0.60.60.91.0-1.01.01.0
Time to tail flick, vehicle, after self-admin0.91.23.3-1.61.6-1.80.2-0.20.1-0.1
Time to tail flick, test, before self-admin1.01.03.70.4-0.41.90.8-0.80.91.0
Time to tail flick, test, after self-admin4.44.65.5-2.22.21.12.4-2.32.32.2
Delta time to tail flick, vehicle, before/after SA0.70.71.6-1.31.3-0.90.5-0.50.40.3
Delta time to tail flick, test, before/after SA3.33.46.7-2.62.6-0.51.7-1.71.61.4
Tibia length1.54.19.13.0-3.03.0-0.90.8-0.6-0.3
Ambulatory time before self-admin1.01.52.21.5-1.5-0.2-1.31.3-1.2-1.2
Ambulatory time after self-admin2.63.06.20.5-0.5-2.5-1.91.9-1.9-2.0
Bone: tissue strength0.20.20.40.6-0.60.4-0.30.3-0.1-0.1
Total heroin consumption0.70.81.00.8-0.8-0.6-1.01.0-1.0-1.0
Bone: trabecular number0.91.53.8-0.20.21.91.2-1.21.21.3
Bone: trabecular spacing1.11.43.20.3-0.3-1.8-1.31.3-1.2-1.3
Bone: trabecular thickness0.40.52.00.3-0.31.40.6-0.60.50.6
Bone: trabecular tissue density1.21.72.21.0-1.0-1.2-1.51.5-1.4-1.5
Water consumed over 24 hours1.01.41.80.9-0.9-1.1-1.31.3-1.3-1.4
Number of responses in last shaping day0.40.40.50.4-0.4-0.7-0.70.7-0.7-0.7