Dok2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Dok2	0.04	0.03	6.3e-03	0.02	0.02	0.01	0.02	3.1e-03	7.2e-03	1.4e-02	6.0e-03
2	Adipose	gene expression	Dok2	0.07	0.05	7.6e-06	0.04	0.04	0.04	0.04	2.8e-05	2.8e-05	5.7e-05	4.7e-05
3	NAcc	intron excision ratio	chr15_52237221_52247028	0.04	0.03	4.3e-05	0.02	0.02	0.02	0.02	3.7e-04	2.4e-04	5.0e-04	3.5e-04
4	Adipose	alternative TSS	XM_063274143.1	0.06	0.04	1.8e-05	0.02	0.04	0.04	0.04	4.0e-03	4.4e-05	3.0e-05	5.6e-05
5	Adipose	alternative TSS	NM_001106048.2	0.06	0.04	1.7e-05	0.02	0.04	0.04	0.04	6.2e-03	3.7e-05	2.4e-05	4.9e-05
6	Adipose	alternative TSS	XM_063274143.1	0.05	0.03	9.4e-05	0.01	0.03	0.02	0.03	1.9e-02	1.9e-04	2.5e-03	3.3e-04
7	Adipose	isoform ratio	XM_063274143.1	0.04	0.03	4.4e-04	0	0.02	0.01	0.01	8.4e-02	1.8e-03	1.1e-02	1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.4	0.8	2.2	-0.1	0.1	1.5	-0.9	0.9	0.9	1.0
Area under the delay curve	0.1	0.2	0.3	0.4	-0.4	-0.1	0.5	-0.5	-0.4	-0.4
BMI with tail	0.2	0.7	2.7	-1.1	1.1	-1.6	0.0	-0.0	-0.1	-0.3
BMI without tail	0.3	1.6	2.8	-1.7	1.7	-0.6	-1.2	1.2	1.0	0.9
Body weight	0.3	1.5	3.1	0.4	-0.4	-1.8	1.2	-1.2	-1.4	-1.4
Weight adjusted by age	0.6	1.8	2.3	1.0	-1.0	-1.3	1.5	-1.5	-1.5	-1.5
Bone surface	0.2	0.4	1.7	0.7	-0.7	1.3	-0.0	0.1	0.2	0.3
Bone volume	0.2	0.4	1.7	0.6	-0.6	1.3	-0.2	0.2	0.4	0.5
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.3	-0.3	-0.2	0.4	-0.4	-0.3	-0.3
Number of licking bursts	0.0	0.1	0.1	-0.3	0.3	-0.1	-0.3	0.3	0.2	0.2
Context. condit. distance diff. score	6.4	7.8	12.4	-3.5	3.5	0.1	-2.8	2.8	2.7	2.5
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	-0.5	-0.3	0.5	-0.5	-0.5	-0.5
Locomotion distance, session 1	1.1	1.4	3.2	1.8	-1.8	0.7	0.8	-0.8	-0.9	-0.8
Locomotion velocity, session 2	0.4	0.5	1.1	1.1	-1.1	0.5	0.5	-0.5	-0.5	-0.4
Locomotion distance, session 2	2.4	3.3	7.3	2.7	-2.7	1.1	1.4	-1.4	-1.5	-1.3
Locomotion velocity, session 3	0.7	0.8	1.9	-1.4	1.4	-1.2	-0.4	0.3	0.4	0.2
Locomotion distance, session 3	0.8	0.9	1.7	-1.3	1.3	-0.2	-0.9	0.9	0.9	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	0.5	-0.5	-0.8	0.7	-0.7	-0.8	-0.8
Stereotopy head waving duration, day 3	1.6	2.0	2.7	0.9	-0.9	-1.6	1.5	-1.5	-1.6	-1.6
Locomotion velocity, session 7	10.7	11.7	14.7	-3.8	3.8	1.1	-3.6	3.6	3.7	3.5
Locomotion distance, session 7	6.7	8.6	9.9	-3.1	3.1	1.3	-3.1	3.1	3.1	3.1
Stereotopy head waving bouts, day 7	1.7	1.9	2.4	1.2	-1.2	-1.1	1.6	-1.6	-1.5	-1.5
Stereotopy head waving duration, day 7	1.7	2.1	2.8	1.0	-1.0	-1.5	1.7	-1.7	-1.6	-1.6
Locomotion velocity, session 8	0.6	0.7	1.4	-1.2	1.2	-0.1	-0.7	0.7	0.7	0.7
Locomotion distance, session 8	0.6	0.8	1.2	-0.6	0.6	1.0	-1.1	1.1	1.0	1.0
Degree of sensitization distance	4.8	5.1	6.4	-2.0	2.0	1.7	-2.5	2.5	2.5	2.5
Degree of sensitization stereotypy	0.8	0.9	1.2	0.6	-0.6	-1.0	1.1	-1.1	-1.1	-1.1
Conditioned locomotion	0.6	0.7	1.3	-1.2	1.2	-0.1	-0.7	0.7	0.8	0.7
Cocaine response after cond. corrected	1.1	1.6	3.8	-2.0	2.0	-1.1	-0.8	0.8	0.8	0.6
Cocaine response after cond. not corrected	0.5	0.7	1.8	-1.3	1.3	-0.7	-0.5	0.5	0.5	0.4
Cocaine response before conditioning	1.0	1.3	3.0	1.7	-1.7	0.9	0.7	-0.7	-0.7	-0.6
Saline control response	0.5	0.7	1.7	1.3	-1.3	0.8	0.6	-0.6	-0.5	-0.4
Bone: connectivity density	1.2	2.0	3.5	-0.6	0.6	1.9	-1.5	1.5	1.5	1.6
Bone: cortical apparent density	1.6	2.6	4.7	-2.2	2.2	-0.4	-1.5	1.5	1.5	1.4
Bone: cortical area	0.3	0.5	1.0	1.0	-1.0	0.4	0.7	-0.6	-0.5	-0.4
Bone: cortical porosity	2.4	2.6	3.0	1.7	-1.7	-0.6	1.7	-1.7	-1.7	-1.7
Bone: cortical porosity	2.3	2.6	3.6	1.9	-1.9	-0.3	1.7	-1.7	-1.7	-1.6
Bone: cortical thickness	0.0	0.0	0.1	0.2	-0.2	0.3	0.2	-0.2	-0.1	-0.0
Bone: cortical thickness	0.9	1.1	2.1	-1.4	1.4	-0.3	-1.0	1.0	0.9	0.8
Bone: cortical tissue density	1.9	2.9	5.4	-2.3	2.3	-0.4	-1.6	1.6	1.6	1.5
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	0.9	-0.9	-0.4	0.9	-0.9	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.3	-0.2	0.2	-1.5	0.8	-0.8	-0.9	-1.0
Condit. Reinf. active responses	0.9	1.1	2.2	1.5	-1.5	0.5	0.9	-0.9	-0.9	-0.8
Condit. Reinf. inactive responses	1.4	1.8	5.5	1.9	-1.9	2.3	0.1	-0.0	0.0	0.2
Incentive salience index mean	1.9	2.4	3.2	1.8	-1.8	-0.3	1.6	-1.6	-1.7	-1.6
Condit. Reinf. lever presses	1.9	2.8	4.8	2.2	-2.2	0.1	1.6	-1.6	-1.7	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.2	0.2	0.7	-0.5	0.5	0.5	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.6	0.6	-0.4	-0.2	0.1	0.2	0.1
Condit. Reinf. active responses	0.4	0.5	1.3	-0.1	0.1	1.2	-0.7	0.7	0.8	0.8
Condit. Reinf. inactive responses	0.6	0.9	3.0	0.3	-0.3	1.7	-0.9	0.9	0.9	1.0
Condit. Reinf. lever presses	0.6	0.9	2.1	1.4	-1.4	0.8	0.5	-0.5	-0.6	-0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	1.1	0.1	-0.1	1.0	-0.5	0.6	0.6	0.6
Conditioned reinforcement - actives	0.4	1.8	2.2	-1.1	1.1	1.1	-1.5	1.5	1.5	1.5
Conditioned reinforcement - inactives	0.6	1.6	6.2	0.7	-0.7	2.5	-0.9	0.9	1.0	1.1
Conditioned locomotion	0.2	0.2	0.3	-0.4	0.4	0.4	-0.6	0.6	0.5	0.6
Patch foraging indifference point 0 sec	1.2	3.3	7.4	2.7	-2.7	2.6	0.8	-0.7	-0.4	-0.2
Patch foraging indifference point AUC	0.2	0.4	1.1	-1.0	1.0	-0.9	-0.2	0.2	0.2	0.1
Delay disc. indifference point, 0s delay	0.6	0.7	1.5	1.2	-1.2	1.0	0.5	-0.5	-0.3	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.2	0.2	0.5	-0.3	0.3	0.4	0.4
Delay disc. indifference point, 2s delay	1.9	2.2	2.8	1.3	-1.3	-1.0	1.7	-1.7	-1.6	-1.6
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.8	0.8	-0.6	-0.2	0.2	0.2	0.1
Delay disc. indifference point, 4s delay	0.8	0.8	1.9	0.1	-0.1	-1.4	1.0	-1.0	-0.9	-1.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.2	-0.2	0.3	0.1	-0.1	-0.0	0.0
Indifference point function ln k	0.2	0.7	1.5	1.2	-1.2	0.5	0.6	-0.6	-0.7	-0.6
Indifference point function log k	0.2	0.7	1.5	1.2	-1.2	0.5	0.6	-0.6	-0.7	-0.6
Patch foraging total patch changes 0 sec	1.1	3.3	7.7	2.8	-2.8	2.3	1.0	-0.9	-0.6	-0.4
Patch foraging total patch changes 12 sec	0.8	1.0	2.3	1.5	-1.5	1.4	0.6	-0.6	-0.3	-0.2
Patch foraging total patch changes 18 sec	0.3	0.7	2.7	0.2	-0.2	1.6	-0.6	0.6	0.8	0.9
Patch foraging total patch changes 24 sec	0.6	1.9	3.5	1.9	-1.9	0.5	1.3	-1.3	-1.2	-1.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.5	0.4	-0.4	0.7	0.0	-0.0	0.1	0.2
Patch foraging time to switch 0 sec	0.2	0.9	1.1	-0.6	0.6	1.0	-1.0	1.0	1.0	1.1
Patch foraging water rate 0 sec	0.3	1.1	1.3	1.1	-1.1	-0.4	1.1	-1.1	-1.1	-1.1
Patch foraging water rate 12 sec	0.3	1.1	1.5	0.9	-0.9	-0.7	1.2	-1.2	-1.2	-1.2
Patch foraging water rate 18 sec	0.8	1.7	4.7	0.1	-0.1	-2.2	1.2	-1.3	-1.4	-1.5
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.8	0.8	-0.8	-0.3	0.3	0.2	0.1
Patch foraging water rate 6 sec	2.8	4.1	5.2	1.9	-1.9	-1.2	2.3	-2.3	-2.2	-2.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.4	1.4	0.5	-0.5	1.2	-0.4	0.4	0.4	0.5
Distance traveled before self-admin	1.3	2.8	3.6	1.9	-1.9	-0.5	1.8	-1.8	-1.7	-1.7
Distance traveled after self-admin	0.7	1.2	3.4	-0.0	0.0	-1.8	1.1	-1.1	-1.1	-1.2
Extensor digitorum longus weight	6.5	25.9	48.7	1.9	-1.9	-7.0	5.5	-5.5	-5.6	-5.9
Bone: elastic displacement	0.4	0.4	1.2	1.0	-1.0	1.1	0.1	-0.1	-0.1	-0.0
Bone: elastic work	1.5	1.9	4.5	2.1	-2.1	1.2	0.9	-0.9	-0.9	-0.7
Bone: endosteal estimation	0.3	0.8	1.3	1.1	-1.1	-0.1	1.0	-0.9	-0.9	-0.8
Bone: endosteal perimeter	0.6	1.4	2.5	1.6	-1.6	0.1	1.2	-1.2	-1.1	-1.0
Epididymis fat weight	0.3	1.7	2.5	-0.7	0.7	1.6	-1.6	1.6	1.3	1.4
Delta time in closed arm before/after self-admin	1.3	1.3	5.0	0.7	-0.7	2.2	-0.8	0.8	0.8	1.0
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.3	0.3	-0.4	0.0	-0.0	-0.0	-0.0
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	0.5	-0.5	-0.9	0.9	-0.9	-0.9	-0.9
Delay discount exponential model param	0.3	0.4	0.6	-0.4	0.4	0.5	-0.8	0.8	0.7	0.7
Extinction: sum of active levers before priming	0.7	1.0	2.6	-0.1	0.1	1.6	-1.0	1.0	1.1	1.1
Active lever presses in extinction session 6	0.9	0.9	1.1	-0.9	0.9	0.6	-1.0	1.0	1.0	1.0
Bone: final force	0.3	0.4	0.6	0.8	-0.8	-0.2	0.7	-0.7	-0.6	-0.6
Bone: final moment	0.5	0.9	1.5	1.2	-1.2	0.0	0.9	-0.9	-0.8	-0.8
Food consumed during 24 hour testing period	0.3	0.5	1.3	1.1	-1.1	1.0	0.2	-0.2	-0.3	-0.2
Glucose	0.4	0.7	1.5	-1.2	1.2	-0.4	-0.7	0.6	0.7	0.6
Heart weight	0.1	0.2	0.9	0.5	-0.5	1.0	-0.0	0.0	0.2	0.3
Delay discount hyperbolic model param	0.4	0.5	0.7	-0.5	0.5	0.6	-0.9	0.9	0.8	0.8
Intermittent access intake day 1-15 change	0.4	2.1	3.2	-0.8	0.8	1.8	-1.6	1.6	1.6	1.7
Intermittent access intake escalation	0.3	1.8	3.7	-0.4	0.4	1.9	-1.4	1.4	1.4	1.5
Intermittent access intake escalation 2	1.0	1.7	2.0	-1.1	1.1	1.1	-1.4	1.4	1.4	1.4
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	-0.7	0.7	-0.0	-0.4	0.4	0.4	0.4
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.4	-0.4	0.3	0.1	-0.1	-0.1	-0.0
Intermitt. access escalation Index	0.0	0.1	0.2	0.4	-0.4	-0.1	0.4	-0.4	-0.4	-0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.2	-0.2	0.1	0.1	-0.1	-0.1	-0.1
Intermittent access day 15 total infusions	0.4	1.0	3.0	0.0	-0.0	1.7	-0.9	0.9	1.0	1.1
Intermittent access terminal intake (last 3 days)	0.7	1.2	1.5	-0.8	0.8	1.1	-1.2	1.2	1.2	1.2
Intermittent access total infusions	0.9	1.1	1.4	-0.7	0.7	1.1	-1.2	1.2	1.1	1.2
Intermittent access day 1 locomotion	0.2	0.4	0.9	0.9	-0.9	0.4	0.5	-0.5	-0.5	-0.4
Intermittent access day 15 total locomotion	0.1	0.4	0.5	-0.5	0.5	0.6	-0.7	0.7	0.7	0.7
Intermittent access total locomotion	0.0	0.1	0.2	0.0	-0.0	0.4	-0.2	0.2	0.3	0.3
Intermittent access standard deviation	0.0	0.1	0.4	0.1	-0.1	0.7	-0.3	0.3	0.3	0.3
Left kidney weight	0.1	1.2	1.9	1.4	-1.4	-0.1	1.0	-1.0	-1.1	-1.1
Right kidney weight	0.5	3.3	5.8	2.4	-2.4	0.3	1.8	-1.8	-1.6	-1.5
Cocaine induced anxiety	1.0	2.7	5.3	2.3	-2.3	0.6	1.5	-1.5	-1.4	-1.2
Post-drug Anxiety	1.2	1.4	3.3	1.8	-1.8	1.5	0.6	-0.5	-0.4	-0.3
Baseline Anxiety	0.7	1.2	1.4	-1.2	1.2	0.4	-1.2	1.2	1.1	1.1
Tail length	0.2	0.8	3.1	1.1	-1.1	1.8	-0.2	0.2	0.2	0.4
Length with tail	0.5	2.3	3.8	2.0	-2.0	0.0	1.5	-1.5	-1.5	-1.4
Length without tail	1.2	6.3	8.2	1.8	-1.8	-2.4	2.8	-2.8	-2.8	-2.9
Times rat made contact with spout	0.5	0.6	0.8	-0.6	0.6	0.7	-0.9	0.9	0.8	0.8
Lifetime Intake	0.6	0.7	0.9	-0.6	0.6	0.9	-1.0	1.0	0.9	1.0
Liver weight, left	2.8	4.8	5.9	2.3	-2.3	-1.2	2.2	-2.2	-2.4	-2.4
Liver weight, right	0.2	0.3	1.0	-0.1	0.1	-1.0	0.3	-0.3	-0.5	-0.6
Locomotor activity	8.0	12.5	19.0	4.4	-4.4	-0.5	3.6	-3.6	-3.6	-3.4
Locomotor testing distance	3.1	7.6	16.0	4.0	-4.0	1.3	2.3	-2.3	-2.2	-2.0
Locomotor testing rearing	2.6	9.5	20.6	4.5	-4.5	1.7	2.5	-2.4	-2.4	-2.1
Locomotion in novel chamber	0.2	0.2	0.9	0.4	-0.4	0.9	-0.2	0.3	0.3	0.4
Locomotion in novel chamber post-restriction	0.2	0.6	1.1	0.3	-0.3	-1.1	0.8	-0.8	-0.8	-0.8
Fecal boli incidents, locomotor time 1	0.5	1.4	1.8	1.0	-1.0	-0.9	1.3	-1.3	-1.3	-1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.6	0.6	-0.7	-0.1	0.1	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.5	0.1	-0.1	1.2	-0.6	0.6	0.6	0.7
Bouts of movement, locomotor time 1	1.5	1.9	6.1	-0.1	0.1	-2.5	1.3	-1.3	-1.3	-1.5
Total resting periods, locomotor time 1	1.4	1.7	6.5	-0.6	0.6	-2.5	1.0	-1.0	-1.1	-1.2
Rest time, locomotor task time 1	0.5	0.8	3.1	-0.5	0.5	-1.7	0.6	-0.6	-0.7	-0.8
Distance moved, locomotor task time 1	0.6	1.7	3.6	-0.4	0.4	1.9	-1.4	1.4	1.4	1.5
Vertical activity count, locomotor time 1	0.1	0.9	2.2	1.4	-1.4	1.5	0.2	-0.2	-0.2	-0.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	0.0	-0.0	-0.7	0.4	-0.4	-0.5	-0.5
Bouts of movement, locomotor time 2	0.6	1.9	6.5	-0.5	0.5	-2.5	1.2	-1.2	-1.2	-1.4
Total resting periods, locomotor time 2	0.5	2.0	7.1	-0.5	0.5	-2.7	1.3	-1.3	-1.2	-1.4
Rest time, locomotor task time 2	0.5	0.8	2.3	-1.2	1.2	-1.5	-0.0	0.0	-0.0	-0.2
Distance moved, locomotor task time 2	1.0	1.3	5.3	0.9	-0.9	2.3	-0.6	0.7	0.7	0.9
Vertical activity count, locomotor time 2	0.5	1.2	2.9	1.7	-1.7	1.2	0.6	-0.5	-0.5	-0.3
Light reinforcement 1	1.0	4.5	6.0	-1.5	1.5	1.9	-2.4	2.4	2.3	2.4
Light reinforcement 2	2.3	5.2	7.1	-2.7	2.7	0.4	-2.4	2.4	2.3	2.2
Bone: marrow area	0.3	0.7	1.3	1.1	-1.1	0.0	0.9	-0.9	-0.8	-0.7
Bone: maximum diameter	0.2	0.5	0.7	0.5	-0.5	-0.6	0.9	-0.9	-0.7	-0.7
Bone: maximum force	0.8	1.6	2.3	1.5	-1.5	-0.2	1.4	-1.4	-1.2	-1.2
Bone: maximum moment	1.2	2.3	3.8	2.0	-2.0	0.1	1.6	-1.6	-1.4	-1.3
Mean time between licks in bursts	0.2	1.1	3.5	0.2	-0.2	1.9	-1.1	1.1	0.9	1.0
Mean num. licks in bursts	0.1	0.2	0.3	-0.2	0.2	0.6	-0.5	0.5	0.5	0.5
Cd content in liver	1.8	2.0	2.5	1.4	-1.4	-0.8	1.6	-1.6	-1.5	-1.5
Co content in liver	1.7	2.0	7.2	-0.5	0.5	-2.7	1.3	-1.3	-1.2	-1.4
Cu content in liver	0.1	0.2	0.6	-0.3	0.3	-0.7	0.3	-0.3	-0.3	-0.3
Fe content in liver	0.6	0.8	2.1	-0.1	0.1	1.4	-0.8	0.8	1.0	1.0
K content in liver	1.2	1.2	1.5	-1.0	1.0	0.9	-1.1	1.1	1.2	1.2
Mg content in liver	1.7	1.9	2.5	-0.8	0.8	1.5	-1.5	1.5	1.5	1.6
Mn content in liver	1.0	1.1	3.1	-0.1	0.1	1.8	-1.0	1.0	1.1	1.2
Na content in liver	3.9	4.4	6.1	2.5	-2.5	-0.3	2.2	-2.2	-2.1	-2.0
Rb content in liver	0.5	0.6	1.2	-1.1	1.1	-0.2	-0.7	0.7	0.7	0.7
Se content in liver	2.2	2.6	6.2	2.5	-2.5	1.9	0.8	-0.8	-0.8	-0.6
Sr content in liver	0.1	0.1	0.2	0.5	-0.5	0.3	0.3	-0.3	-0.2	-0.1
Zn content in liver	0.4	0.5	1.1	1.1	-1.1	0.8	0.5	-0.5	-0.4	-0.3
Bone: minimum diameter	1.1	2.0	3.3	1.8	-1.8	0.1	1.5	-1.5	-1.3	-1.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.5	0.5	-0.3	-0.2	0.2	0.2	0.2
Time in novel zone, hab. session 1	0.4	0.4	1.8	-0.5	0.5	-1.3	0.4	-0.4	-0.4	-0.5
Total zone transitions, hab. session 1	0.8	1.1	1.8	1.3	-1.3	-0.0	1.0	-1.0	-1.0	-1.0
Total locomotion distance, hab. session 1	0.9	1.3	2.8	1.7	-1.7	0.6	0.9	-0.9	-0.9	-0.8
Locomotion velocity, hab. session 1	1.7	2.4	5.5	2.4	-2.4	1.1	1.1	-1.1	-1.1	-0.9
Time in familiar zone, hab. session 2	1.0	1.2	3.5	-1.5	1.5	-1.9	-0.0	0.0	0.0	-0.2
Time in novel zone, hab. session 2	0.4	0.5	1.2	1.0	-1.0	1.1	0.1	-0.1	-0.1	0.0
Total zone transitions, hab. session 2	3.4	4.3	5.9	2.4	-2.4	-0.7	2.0	-2.0	-2.2	-2.1
Total locomotion distance, hab. session 2	1.3	1.8	3.0	1.7	-1.7	-0.1	1.2	-1.2	-1.3	-1.2
Locomotion velocity, hab. session 2	2.3	3.0	4.8	2.2	-2.2	-0.3	1.7	-1.7	-1.8	-1.7
Novel to familiar place preference ratio	0.4	0.5	2.1	0.6	-0.6	1.4	-0.4	0.5	0.5	0.6
Novelty place preference	0.3	0.4	1.6	0.6	-0.6	1.3	-0.4	0.4	0.4	0.5
Time in novel zone, NPP test	0.2	0.2	0.9	0.6	-0.6	0.9	-0.2	0.2	0.2	0.2
Total zone transitions, NPP test	0.8	1.1	2.8	1.7	-1.7	1.0	0.5	-0.5	-0.6	-0.5
Total locomotion distance, NPP test	1.2	1.7	6.1	1.6	-1.6	2.5	-0.4	0.4	0.3	0.5
Locomotion velocity, NPP test	1.1	1.6	5.9	1.5	-1.5	2.4	-0.4	0.4	0.3	0.5
Intraocular pressure	0.2	0.4	1.0	0.1	-0.1	1.0	-0.7	0.7	0.5	0.5
Delta distance traveled before/after self-admin	1.6	1.7	5.5	-1.8	1.8	-2.4	-0.0	0.0	-0.1	-0.3
Delta ambulatory time before/after self-admin	0.9	1.5	5.6	-1.5	1.5	-2.4	0.2	-0.2	-0.3	-0.5
Parametrial fat weight	0.8	1.9	4.1	-0.4	0.4	2.0	-1.4	1.5	1.5	1.6
Pavlov. Cond. lever latency	0.4	0.5	1.0	-1.0	1.0	-0.4	-0.5	0.5	0.6	0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	-0.0	0.2	-0.1	0.1	0.1	0.1
Pavlov. Cond. change in total contacts	1.6	1.7	2.2	1.4	-1.4	-0.6	1.4	-1.4	-1.5	-1.4
Pavlov. Cond. index score	0.3	0.4	0.7	0.8	-0.8	0.0	0.6	-0.6	-0.7	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.8	0.9	-0.9	0.2	0.6	-0.6	-0.6	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.8	-0.8	0.5	0.3	-0.3	-0.4	-0.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.4	0.4	0.5	-0.6	0.6	0.7	0.7
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.3	1.5	-1.5	0.7	0.7	-0.7	-0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.8	0.9	-0.9	-0.1	0.7	-0.7	-0.8	-0.8
Pavlov. Cond. response bias	0.2	0.2	0.3	0.5	-0.5	-0.3	0.5	-0.5	-0.5	-0.5
Pavlov. Cond. lever latency	2.1	3.0	4.8	-2.2	2.2	0.1	-1.7	1.7	1.7	1.7
Pavlov. Cond. magazine entry latency	0.5	0.7	1.7	1.3	-1.3	0.6	0.6	-0.5	-0.6	-0.5
Pavlov. Cond. change in total contacts	1.2	2.9	3.5	1.8	-1.8	-0.9	1.8	-1.8	-1.9	-1.8
Pavlov. Cond. index score	1.8	2.8	4.4	2.1	-2.1	-0.2	1.6	-1.6	-1.7	-1.6
Pavlov. Cond. latency score	1.7	2.6	4.5	2.1	-2.1	-0.0	1.5	-1.5	-1.6	-1.5
Pavlov. Cond. lever contacts	1.8	2.7	4.8	2.2	-2.2	0.1	1.5	-1.5	-1.6	-1.5
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	-1.0	1.0	-0.4	-0.4	0.4	0.5	0.4
Pavlov. Cond. intertrial magazine entries	1.7	3.7	7.7	-0.5	0.5	2.8	-2.1	2.1	2.1	2.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.5	3.8	1.9	-1.9	-0.3	1.6	-1.6	-1.6	-1.6
Pavlov. Cond. response bias	2.1	2.9	5.0	2.2	-2.2	0.1	1.6	-1.6	-1.7	-1.6
Time in closed arm before self-admin	0.4	0.7	2.6	-0.6	0.6	-1.6	0.5	-0.5	-0.5	-0.7
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	-0.0	-0.1	-0.1
Time in open arm before self-admin	0.2	0.3	0.5	0.7	-0.7	0.2	0.4	-0.4	-0.4	-0.4
Time in open arm after self-admin	0.1	0.1	0.2	0.5	-0.5	0.3	0.2	-0.2	-0.1	-0.1
Bone: periosteal estimation	0.4	0.9	1.6	1.3	-1.3	0.1	1.0	-1.0	-0.8	-0.8
Bone: periosteal perimeter	0.4	0.7	1.3	1.1	-1.1	0.0	0.9	-0.9	-0.7	-0.7
Bone: post-yield work	0.4	0.7	0.8	-0.9	0.9	0.2	-0.9	0.9	0.9	0.9
Progressive ratio test 1 active lever presses	0.4	0.6	1.5	-1.2	1.2	-0.7	-0.6	0.6	0.5	0.4
Progressive ratio test 1 breakpoint	0.4	0.7	1.6	-1.3	1.3	-0.8	-0.6	0.5	0.5	0.4
Progressive ratio test 1 inactive lever presses	0.5	1.3	1.7	-1.0	1.0	0.9	-1.3	1.3	1.3	1.3
Progressive ratio test 2 active lever presses	0.4	0.5	0.9	-0.9	0.9	-0.1	-0.7	0.7	0.7	0.6
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	-0.7	0.7	-0.0	-0.5	0.5	0.5	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.4	-0.4	0.4	0.6	-0.6	0.6	0.6	0.6
Incentive Sensitization - Responses	0.0	0.1	0.3	-0.1	0.1	0.6	-0.4	0.4	0.4	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.1	-0.1	0.7	-0.3	0.3	0.4	0.4
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.9	-0.9	0.9	-0.0	-0.8	0.8	0.8	0.7
Progressive ratio	0.1	0.2	0.5	-0.7	0.7	-0.4	-0.3	0.3	0.2	0.1
Food seeking constrained by brief footshock	2.8	3.4	8.1	-2.8	2.8	-2.5	-0.8	0.7	0.6	0.3
Seeking ratio, punishment vs. effort	0.2	0.5	1.6	-0.9	0.9	-1.3	-0.0	0.0	0.0	-0.1
Retroperitoneal fat weight	0.1	0.6	0.8	-0.9	0.9	0.4	-0.7	0.7	0.9	0.9
Reaction time number correct	0.1	0.3	1.5	-0.5	0.5	-1.2	0.1	-0.2	-0.3	-0.4
Reaction time mean minus median	0.1	0.9	1.4	1.2	-1.2	-0.1	1.0	-1.0	-0.9	-0.9
Reaction time mean minus median AUC	0.0	0.3	0.4	0.6	-0.6	-0.1	0.5	-0.5	-0.6	-0.6
Reaction time num false alarms	0.2	0.4	0.6	0.8	-0.8	-0.2	0.5	-0.5	-0.7	-0.7
Reaction time num false alarms AUC	0.1	0.2	0.4	0.7	-0.7	-0.2	0.3	-0.3	-0.6	-0.5
Reaction time trials correct on left	0.1	0.3	1.5	-0.5	0.5	-1.2	0.1	-0.2	-0.3	-0.4
Reaction time trials on left	0.1	0.3	1.2	-0.6	0.6	-1.1	0.0	-0.1	-0.2	-0.3
Reaction time mean	0.2	0.4	0.5	0.7	-0.7	-0.3	0.6	-0.6	-0.7	-0.7
Reaction time mean AUC	0.3	0.7	0.9	0.9	-0.9	-0.4	0.9	-0.9	-0.9	-0.9
Median of all reaction times	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.3	-0.4	-0.4
Reaction time omissions	0.9	1.4	2.4	-0.4	0.4	1.5	-1.3	1.4	1.3	1.4
Reaction time false alarm rate	0.1	0.1	0.2	0.5	-0.5	0.4	-0.0	0.0	-0.1	-0.1
Reaction time premature initiation rate	0.6	0.9	4.0	-0.9	0.9	-2.0	0.3	-0.3	-0.5	-0.7
Reaction time premature initiations	0.5	1.4	6.1	-1.2	1.2	-2.5	0.2	-0.2	-0.5	-0.7
Std. dev. reaction times	0.2	0.5	0.8	0.9	-0.9	-0.2	0.7	-0.7	-0.8	-0.8
Reaction time trials completed	0.1	0.3	1.2	-0.6	0.6	-1.1	0.0	-0.1	-0.2	-0.3
Reaction time trials AUC	0.1	0.3	1.1	-0.5	0.5	-1.0	0.0	-0.1	-0.2	-0.3
Run reversals in cocaine runway, females	1.3	1.4	3.2	-0.3	0.3	1.8	-1.3	1.3	1.2	1.3
Run reversals in cocaine runway, males	1.1	1.2	1.6	0.7	-0.7	-1.3	1.2	-1.2	-1.2	-1.3
Latency to leave start box in cocaine runway	0.2	0.3	0.5	0.3	-0.3	-0.7	0.6	-0.6	-0.6	-0.6
Latency to leave start box in cocaine runway, F	0.8	1.0	1.4	0.6	-0.6	-1.2	1.1	-1.1	-1.1	-1.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.2	0.3	-0.1	0.1	0.1	0.1
Std. dev. time between licks in bursts	1.0	1.8	4.2	2.0	-2.0	2.0	0.2	-0.2	-0.4	-0.2
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	0.1	-0.2	0.0	-0.0	-0.0	-0.0
Short access day 1 total inactive lever presses	0.1	0.3	0.7	0.8	-0.8	0.6	0.3	-0.3	-0.2	-0.2
Short access day 10 total inactive lever presses	0.0	0.2	0.2	-0.4	0.4	0.4	-0.5	0.5	0.5	0.5
Short access day 1 total infusions	0.1	0.2	0.5	-0.7	0.7	-0.4	-0.3	0.3	0.3	0.2
Short access day 10 total infusions	0.6	0.9	1.2	1.1	-1.1	-0.3	1.0	-1.0	-1.0	-1.0
Short access total infusions	0.0	0.1	0.1	0.3	-0.3	-0.1	0.3	-0.3	-0.3	-0.3
Short access day 1 locomotion	1.1	1.7	2.1	1.4	-1.4	-0.7	1.4	-1.4	-1.4	-1.4
Short access day 10 total locomotion	0.1	0.3	0.7	0.8	-0.8	0.2	0.6	-0.6	-0.5	-0.5
Short access total locomotion	0.9	1.3	2.2	1.5	-1.5	0.0	1.1	-1.1	-1.1	-1.0
One hour access (0.3 mA shock)	0.2	0.3	1.2	0.5	-0.5	1.1	-0.2	0.2	0.2	0.3
Compulsive drug intake	0.4	0.6	1.5	1.2	-1.2	1.1	0.3	-0.2	-0.2	-0.1
One hour access (shock baseline)	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.0
Social response proportion	1.8	2.3	5.5	-2.4	2.4	-0.9	-1.0	1.0	1.1	1.0
Social responses	1.0	1.3	1.8	-1.0	1.0	1.0	-1.1	1.1	1.3	1.3
Social time	0.4	0.7	1.5	1.2	-1.2	1.1	0.5	-0.4	-0.3	-0.2
Soleus weight	0.4	1.3	4.4	-0.1	0.1	-2.1	0.9	-0.9	-1.1	-1.3
Bone: stiffness	0.6	1.0	1.4	0.8	-0.8	-0.9	1.2	-1.2	-1.0	-1.1
Tibialis anterior weight	5.0	17.1	25.2	2.2	-2.2	-5.0	4.6	-4.6	-4.6	-4.8
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.1	-0.6	0.6	0.9	-1.0	1.0	1.0	1.0
Time to tail flick, vehicle, after self-admin	0.6	1.2	3.3	-1.6	1.6	-1.8	-0.2	0.2	0.1	-0.1
Time to tail flick, test, before self-admin	0.9	1.0	3.7	0.4	-0.4	1.9	-0.8	0.8	0.9	1.0
Time to tail flick, test, after self-admin	4.3	4.6	5.5	-2.2	2.2	1.1	-2.4	2.3	2.3	2.2
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	1.6	-1.3	1.3	-0.9	-0.5	0.5	0.4	0.3
Delta time to tail flick, test, before/after SA	2.8	3.4	6.7	-2.6	2.6	-0.5	-1.7	1.7	1.6	1.4
Tibia length	1.5	4.1	9.1	3.0	-3.0	3.0	0.9	-0.8	-0.6	-0.3
Ambulatory time before self-admin	0.5	1.5	2.2	1.5	-1.5	-0.2	1.3	-1.3	-1.2	-1.2
Ambulatory time after self-admin	1.9	3.0	6.2	0.5	-0.5	-2.5	1.9	-1.9	-1.9	-2.0
Bone: tissue strength	0.2	0.2	0.4	0.6	-0.6	0.4	0.3	-0.3	-0.1	-0.1
Total heroin consumption	0.7	0.8	1.0	0.8	-0.8	-0.6	1.0	-1.0	-1.0	-1.0
Bone: trabecular number	0.8	1.5	3.8	-0.2	0.2	1.9	-1.2	1.2	1.2	1.3
Bone: trabecular spacing	1.0	1.4	3.2	0.3	-0.3	-1.8	1.3	-1.3	-1.2	-1.3
Bone: trabecular thickness	0.4	0.5	2.0	0.3	-0.3	1.4	-0.6	0.6	0.5	0.6
Bone: trabecular tissue density	1.0	1.7	2.2	1.0	-1.0	-1.2	1.5	-1.5	-1.4	-1.5
Water consumed over 24 hours	0.7	1.4	1.8	0.9	-0.9	-1.1	1.3	-1.3	-1.3	-1.4
Number of responses in last shaping day	0.3	0.4	0.5	0.4	-0.4	-0.7	0.7	-0.7	-0.7	-0.7