Hub : Genes

Dnal4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Dnal4 0.13 0.06 1.4e-09 0.1 0.11 0.12 0.12 2.8e-08 2.3e-09 3.1e-10 1.2e-09
2 Adipose gene expression Dnal4 0.13 0.05 1.5e-15 0.14 0.13 0.13 0.14 4.4e-15 7.5e-14 1.7e-14 9.4e-15
3 IL gene expression Dnal4 0.21 0.1 2.1e-03 0.05 0.04 -0.01 0.02 2.0e-02 3.2e-02 6.9e-01 1.0e-01
4 Liver gene expression Dnal4 0.12 0.05 4.2e-14 0.12 0.12 0.12 0.12 5.4e-13 7.1e-13 4.7e-13 5.5e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.10.10.20.50.3-0.50.2
Area under the delay curve4.65.35.72.42.2-2.22.4
BMI with tail0.93.14.2-1.8-2.01.4-1.8
BMI without tail0.61.72.3-1.2-1.01.5-1.5
Body weight2.19.410.2-3.2-2.73.2-3.2
Weight adjusted by age0.40.61.5-0.9-0.21.2-0.5
Bone surface0.20.40.90.61.0-0.20.7
Bone volume0.10.10.30.50.3-0.10.4
Breakpoint value in progressive ratio session0.10.10.10.30.3-0.10.2
Number of licking bursts0.61.01.51.21.2-0.60.9
Context. condit. distance diff. score8.510.313.4-2.7-3.33.7-3.1
Locomotion velocity, session 10.80.92.1-0.21.5-0.21.1
Locomotion distance, session 15.97.412.12.43.5-1.73.0
Locomotion velocity, session 20.10.10.4-0.6-0.1-0.10.4
Locomotion distance, session 27.610.614.52.73.8-3.03.4
Locomotion velocity, session 32.22.53.9-1.5-1.32.0-1.4
Locomotion distance, session 30.30.40.70.70.40.90.3
Stereotopy head waving bouts, day 30.10.20.5-0.7-0.2-0.1-0.4
Stereotopy head waving duration, day 31.82.24.3-2.1-1.40.7-1.4
Locomotion velocity, session 70.80.91.9-0.4-1.41.1-0.7
Locomotion distance, session 70.20.20.60.8-0.00.20.4
Stereotopy head waving bouts, day 75.56.28.3-2.9-2.72.2-2.1
Stereotopy head waving duration, day 75.26.28.4-2.8-2.91.7-2.4
Locomotion velocity, session 82.02.44.1-2.0-1.31.8-0.8
Locomotion distance, session 80.50.71.6-0.8-0.61.3-0.7
Degree of sensitization distance0.60.71.5-0.8-1.2-0.1-0.7
Degree of sensitization stereotypy4.65.07.1-2.7-2.42.0-1.7
Conditioned locomotion0.50.60.7-0.9-0.80.7-0.6
Cocaine response after cond. corrected0.10.10.4-0.30.2-0.40.6
Cocaine response after cond. not corrected0.10.10.2-0.30.0-0.40.4
Cocaine response before conditioning0.10.10.10.2-0.1-0.1-0.4
Saline control response0.70.91.3-0.9-1.10.8-1.0
Bone: connectivity density0.00.00.10.00.10.3-0.1
Bone: cortical apparent density0.30.40.7-0.1-0.70.4-0.9
Bone: cortical area0.10.20.3-0.6-0.3-0.30.3
Bone: cortical porosity0.50.51.1-1.0-1.00.1-0.1
Bone: cortical porosity1.01.12.4-1.6-1.30.4-0.2
Bone: cortical thickness0.50.81.40.70.3-1.21.1
Bone: cortical thickness2.22.64.21.31.7-1.32.1
Bone: cortical tissue density0.30.40.7-0.2-0.70.5-0.8
Condit. Reinf. active minus inactive responses0.30.30.60.70.6-0.80.2
Condit. Reinf. active-inactive response ratio0.10.10.3-0.1-0.50.1-0.5
Condit. Reinf. active responses0.60.81.41.20.9-1.0-0.0
Condit. Reinf. inactive responses0.60.71.81.30.9-0.6-0.2
Incentive salience index mean0.50.60.90.90.7-0.90.4
Condit. Reinf. lever presses0.30.40.70.80.4-0.80.2
Condit. Reinf. active minus inactive responses1.11.42.40.91.6-0.71.4
Condit. Reinf. active-inactive response ratio0.40.41.00.21.0-0.30.8
Condit. Reinf. active responses0.40.61.10.51.0-0.20.9
Condit. Reinf. inactive responses0.10.20.40.40.20.00.6
Condit. Reinf. lever presses0.60.81.61.31.0-0.80.1
Condit. Reinf. lever reinforcers received0.40.51.00.51.0-0.40.8
Conditioned reinforcement - actives1.83.05.01.61.9-1.12.2
Conditioned reinforcement - inactives3.65.36.52.42.6-1.92.3
Conditioned locomotion1.62.12.61.01.6-1.61.6
Patch foraging indifference point 0 sec0.10.20.50.20.1-0.7-0.5
Patch foraging indifference point AUC2.53.75.31.92.0-1.32.3
Delay disc. indifference point, 0s delay0.20.31.0-0.2-0.1-1.0-0.0
Delay disc. indifference point, 16s delay5.05.56.22.32.5-2.22.4
Delay disc. indifference point, 2s delay5.76.47.62.22.4-2.82.7
Delay disc. indifference point, 24s delay1.01.12.00.71.3-0.11.4
Delay disc. indifference point, 4s delay2.72.83.31.41.7-1.81.7
Delay disc. indifference point, 8s delay3.44.06.52.51.8-1.81.8
Indifference point function ln k2.84.96.1-2.3-2.31.7-2.5
Indifference point function log k2.84.96.1-2.3-2.31.7-2.5
Patch foraging total patch changes 0 sec0.30.51.50.60.4-1.2-0.3
Patch foraging total patch changes 12 sec0.50.61.20.40.6-1.10.8
Patch foraging total patch changes 18 sec1.11.72.41.11.3-1.51.2
Patch foraging total patch changes 24 sec0.61.01.81.40.5-1.10.8
Patch foraging total patch changes 6 sec1.72.53.61.41.5-1.91.6
Patch foraging time to switch 0 sec0.10.10.2-0.4-0.4-0.30.1
Patch foraging water rate 0 sec0.00.10.20.10.30.1-0.4
Patch foraging water rate 12 sec0.10.31.0-0.3-0.2-0.2-1.0
Patch foraging water rate 18 sec0.10.10.2-0.50.2-0.1-0.4
Patch foraging water rate 24 sec1.92.74.6-1.7-1.41.1-2.2
Patch foraging water rate 6 sec0.30.51.0-0.1-0.50.7-1.0
Seeking ratio, delayed vs. immediate footshock0.10.20.30.60.3-0.40.3
Distance traveled before self-admin2.22.84.71.61.6-2.21.3
Distance traveled after self-admin0.50.61.20.51.1-0.70.7
Extensor digitorum longus weight0.52.03.91.01.3-2.01.2
Bone: elastic displacement0.40.50.9-0.9-0.20.6-0.8
Bone: elastic work0.50.62.3-1.5-0.40.1-0.2
Bone: endosteal estimation0.20.41.3-1.1-0.30.5-0.3
Bone: endosteal perimeter0.71.53.5-1.9-1.11.1-0.5
Epididymis fat weight2.910.011.8-3.2-3.43.1-2.9
Delta time in closed arm before/after self-admin1.01.01.50.61.0-1.01.2
Delta time in open arm before/after self-admin0.10.10.30.20.5-0.10.1
Diff in mean of infusions in LGA sessions0.20.30.70.10.50.80.2
Delay discount exponential model param4.75.25.7-2.4-2.32.2-2.3
Extinction: sum of active levers before priming0.91.02.00.61.0-0.91.4
Active lever presses in extinction session 60.10.10.2-0.00.20.10.4
Bone: final force0.10.10.2-0.40.1-0.30.5
Bone: final moment0.10.10.2-0.50.2-0.30.5
Food consumed during 24 hour testing period0.10.10.3-0.6-0.2-0.10.4
Glucose0.10.10.2-0.1-0.30.4-0.4
Heart weight2.03.15.1-2.3-1.71.2-1.7
Delay discount hyperbolic model param5.05.56.0-2.5-2.32.3-2.4
Intermittent access intake day 1-15 change0.00.10.2-0.10.20.4-0.4
Intermittent access intake escalation0.00.10.10.00.30.4-0.4
Intermittent access intake escalation 20.10.10.20.10.10.3-0.4
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.1-0.2
Intermitt. access day 15 inactive lever presses0.40.81.31.11.1-0.40.9
Intermitt. access escalation Index0.10.10.20.4-0.4-0.20.2
Intermittent access day 1 total infusions2.43.96.11.51.9-1.82.5
Intermittent access day 15 total infusions1.92.84.01.52.0-1.41.8
Intermittent access terminal intake (last 3 days)2.12.73.71.41.9-1.41.8
Intermittent access total infusions4.85.78.02.02.5-2.22.8
Intermittent access day 1 locomotion2.43.03.81.71.7-2.01.6
Intermittent access day 15 total locomotion0.40.71.00.81.0-0.61.0
Intermittent access total locomotion0.70.81.10.90.8-0.81.1
Intermittent access standard deviation0.51.01.50.61.1-1.21.0
Left kidney weight4.320.032.1-5.7-4.34.3-3.2
Right kidney weight5.625.739.2-6.3-4.75.0-4.1
Cocaine induced anxiety0.70.91.0-1.0-1.01.0-0.9
Post-drug Anxiety1.51.62.1-1.0-1.21.5-1.4
Baseline Anxiety0.50.50.80.90.8-0.50.7
Tail length0.51.83.1-0.8-0.61.8-1.7
Length with tail1.56.79.6-2.6-1.83.1-2.7
Length without tail1.65.38.4-2.9-2.02.0-2.2
Times rat made contact with spout0.50.50.90.90.90.20.7
Lifetime Intake5.26.39.32.02.4-2.43.1
Liver weight, left1.01.72.6-1.0-1.51.6-0.8
Liver weight, right7.413.016.1-3.1-3.74.0-3.5
Locomotor activity1.52.34.1-2.0-1.41.4-1.2
Locomotor testing distance0.00.10.2-0.1-0.40.2-0.1
Locomotor testing rearing0.51.02.0-1.2-1.40.6-0.4
Locomotion in novel chamber0.10.10.30.60.10.2-0.3
Locomotion in novel chamber post-restriction0.61.01.31.10.8-0.81.1
Fecal boli incidents, locomotor time 10.91.21.90.90.9-1.21.4
Change in fecal boli incidents, locomotor task2.22.24.3-1.5-1.22.1-0.9
Time >=10cm from walls, locomotor time 10.40.41.2-1.1-0.10.5-0.2
Bouts of movement, locomotor time 10.40.50.8-0.7-0.80.9-0.2
Total resting periods, locomotor time 10.10.10.1-0.3-0.30.30.1
Rest time, locomotor task time 10.10.10.5-0.2-0.70.10.1
Distance moved, locomotor task time 10.60.81.4-0.9-0.60.9-1.2
Vertical activity count, locomotor time 10.41.01.6-0.6-0.91.1-1.3
Time >=10cm from walls, locomotor time 20.30.40.8-0.9-0.40.5-0.7
Bouts of movement, locomotor time 20.10.20.30.3-0.6-0.40.3
Total resting periods, locomotor time 20.20.30.60.5-0.1-0.70.8
Rest time, locomotor task time 20.30.40.90.60.6-0.31.0
Distance moved, locomotor task time 20.91.11.7-1.0-0.90.8-1.3
Vertical activity count, locomotor time 21.01.31.6-0.9-1.21.2-1.3
Light reinforcement 10.10.30.90.00.4-0.90.2
Light reinforcement 20.91.43.1-1.1-1.80.6-0.9
Bone: marrow area0.20.41.4-1.2-0.30.5-0.3
Bone: maximum diameter0.71.33.8-2.0-1.00.5-0.3
Bone: maximum force0.20.30.8-0.40.2-0.40.9
Bone: maximum moment0.20.30.7-0.60.2-0.30.8
Mean time between licks in bursts0.30.82.20.40.8-1.50.5
Mean num. licks in bursts0.50.71.3-0.7-0.81.1-0.6
Cd content in liver0.40.41.0-1.00.00.9-0.1
Co content in liver1.21.31.60.91.3-1.31.2
Cu content in liver3.84.66.62.52.6-1.81.5
Fe content in liver2.63.27.1-2.7-1.21.3-1.6
K content in liver0.20.20.50.60.70.20.3
Mg content in liver0.30.30.60.60.80.30.4
Mn content in liver0.10.10.10.2-0.40.30.1
Na content in liver0.10.10.20.40.4-0.00.0
Rb content in liver0.70.81.20.71.0-0.71.1
Se content in liver0.20.30.5-0.70.20.5-0.7
Sr content in liver2.21.94.92.20.9-1.10.8
Zn content in liver0.20.30.60.30.80.5-0.0
Bone: minimum diameter0.00.10.2-0.3-0.3-0.00.4
Time in familiar zone, hab. session 10.40.30.70.30.8-0.20.8
Time in novel zone, hab. session 11.61.62.3-1.5-1.20.7-1.4
Total zone transitions, hab. session 11.11.53.31.41.8-0.20.8
Total locomotion distance, hab. session 10.20.30.40.60.60.6-0.2
Locomotion velocity, hab. session 10.50.81.61.21.20.20.3
Time in familiar zone, hab. session 20.20.20.60.1-0.10.8-0.6
Time in novel zone, hab. session 20.20.20.60.10.2-0.50.8
Total zone transitions, hab. session 22.63.35.91.52.4-1.31.8
Total locomotion distance, hab. session 22.02.74.01.32.0-1.61.6
Locomotion velocity, hab. session 22.63.55.31.62.3-1.81.8
Novel to familiar place preference ratio3.13.45.3-2.3-1.32.0-1.6
Novelty place preference4.44.76.8-2.6-1.72.4-1.9
Time in novel zone, NPP test5.15.57.6-2.7-1.72.6-2.1
Total zone transitions, NPP test2.33.46.41.82.5-1.01.7
Total locomotion distance, NPP test1.41.93.21.31.8-1.11.2
Locomotion velocity, NPP test1.92.73.31.71.8-1.61.5
Intraocular pressure0.40.61.1-1.0-0.60.8-0.6
Delta distance traveled before/after self-admin1.92.03.9-1.5-1.02.0-0.8
Delta ambulatory time before/after self-admin1.01.22.6-1.4-0.51.6-0.4
Parametrial fat weight1.33.04.3-1.2-2.11.7-1.8
Pavlov. Cond. lever latency0.10.10.3-0.2-0.00.5-0.1
Pavlov. Cond. magazine entry latency1.21.62.41.11.0-1.31.5
Pavlov. Cond. change in total contacts3.23.44.31.81.5-2.12.0
Pavlov. Cond. index score0.60.71.10.80.6-1.01.0
Pavlov. Cond. latency score0.30.30.60.50.3-0.80.7
Pavlov. Cond. lever contacts0.60.71.11.10.4-1.00.7
Pavlov. Cond. magazine entry number1.62.02.6-1.5-1.21.3-1.6
Pavlov. Cond. intertrial magazine entries0.80.92.10.91.4-0.90.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.00.90.6-0.91.0
Pavlov. Cond. response bias1.31.61.81.41.0-1.31.3
Pavlov. Cond. lever latency0.20.30.5-0.5-0.40.70.5
Pavlov. Cond. magazine entry latency2.73.34.31.82.1-2.01.3
Pavlov. Cond. change in total contacts0.20.30.7-0.30.8-0.8-0.1
Pavlov. Cond. index score0.81.11.71.01.3-1.30.3
Pavlov. Cond. latency score1.21.52.31.21.5-1.40.5
Pavlov. Cond. lever contacts0.20.30.50.40.4-0.7-0.6
Pavlov. Cond. magazine entry number0.70.81.3-0.8-1.11.0-0.5
Pavlov. Cond. intertrial magazine entries0.20.30.60.1-0.50.40.8
Pavlov. Cond. lever-magazine prob. diff.0.81.01.70.91.2-1.30.3
Pavlov. Cond. response bias0.50.71.30.80.8-1.20.1
Time in closed arm before self-admin0.70.92.41.00.4-1.50.3
Time in closed arm after self-admin0.10.10.30.1-0.5-0.20.3
Time in open arm before self-admin0.30.30.7-0.1-0.20.8-0.7
Time in open arm after self-admin0.20.20.50.20.20.5-0.7
Bone: periosteal estimation0.20.41.3-1.1-0.40.10.0
Bone: periosteal perimeter1.22.15.0-2.2-1.21.2-0.7
Bone: post-yield work0.91.32.20.61.4-0.81.5
Progressive ratio test 1 active lever presses3.74.66.31.62.3-2.02.5
Progressive ratio test 1 breakpoint3.64.46.11.62.2-1.92.5
Progressive ratio test 1 inactive lever presses3.44.96.72.02.0-2.62.3
Progressive ratio test 2 active lever presses3.44.07.11.91.8-1.42.7
Progressive ratio test 2 breakpoint3.94.47.92.01.9-1.52.8
Progressive ratio test 2 inactive lever presses2.43.95.62.41.9-1.32.2
Incentive Sensitization - Responses0.40.61.21.00.4-0.11.1
Incentive Sensitization - Breakpoint0.40.51.20.90.3-0.01.1
Sum of active levers in priming session hrs 5-60.10.10.1-0.10.10.4-0.3
Progressive ratio0.10.10.20.20.5-0.50.0
Food seeking constrained by brief footshock0.10.20.3-0.10.3-0.50.5
Seeking ratio, punishment vs. effort0.10.10.2-0.2-0.2-0.20.5
Retroperitoneal fat weight3.615.420.3-4.3-4.53.4-3.3
Reaction time number correct0.10.20.70.1-0.30.9-0.1
Reaction time mean minus median0.00.00.0-0.20.00.20.1
Reaction time mean minus median AUC0.20.60.8-0.7-0.90.9-0.5
Reaction time num false alarms0.30.40.9-0.6-0.30.3-0.9
Reaction time num false alarms AUC0.20.30.8-0.5-0.30.2-0.9
Reaction time trials correct on left0.10.20.70.1-0.30.9-0.1
Reaction time trials on left0.10.20.70.1-0.30.8-0.0
Reaction time mean0.10.20.4-0.4-0.40.6-0.3
Reaction time mean AUC0.10.20.5-0.3-0.40.7-0.1
Median of all reaction times0.10.10.3-0.3-0.40.6-0.2
Reaction time omissions0.60.92.40.80.5-0.51.5
Reaction time false alarm rate0.20.20.6-0.5-0.3-0.1-0.8
Reaction time premature initiation rate0.20.30.9-0.00.1-0.60.9
Reaction time premature initiations0.10.10.5-0.0-0.20.00.7
Std. dev. reaction times0.40.71.0-0.9-0.81.0-0.5
Reaction time trials completed0.10.20.70.1-0.30.8-0.0
Reaction time trials AUC0.10.30.8-0.1-0.50.9-0.2
Run reversals in cocaine runway, females0.90.91.4-0.9-1.00.7-1.2
Run reversals in cocaine runway, males0.50.51.00.11.00.50.9
Latency to leave start box in cocaine runway0.50.51.3-1.1-0.80.3-0.5
Latency to leave start box in cocaine runway, F0.20.30.7-0.20.5-0.90.3
Latency to leave start box in cocaine runway, M3.23.03.9-1.6-2.01.9-1.4
Std. dev. time between licks in bursts0.60.81.40.71.2-1.10.4
Total sessions with >9 infusions1.31.63.00.70.9-1.41.7
Short access day 1 total inactive lever presses1.82.44.20.92.1-1.61.5
Short access day 10 total inactive lever presses0.51.21.7-0.6-1.11.3-1.1
Short access day 1 total infusions0.81.11.51.00.9-1.21.1
Short access day 10 total infusions1.01.32.40.60.8-1.41.5
Short access total infusions2.63.35.41.31.5-2.02.3
Short access day 1 locomotion0.40.40.70.60.6-0.80.6
Short access day 10 total locomotion0.61.22.31.50.5-1.40.4
Short access total locomotion0.91.02.40.90.5-1.60.8
One hour access (0.3 mA shock)7.08.09.62.72.8-2.73.1
Compulsive drug intake0.50.51.00.90.50.21.0
One hour access (shock baseline)1.72.64.51.21.6-2.11.4
Social response proportion0.50.51.3-1.10.3-0.90.0
Social responses1.01.32.40.21.3-1.61.0
Social time3.44.65.91.92.3-2.42.0
Soleus weight0.41.22.11.40.9-0.51.4
Bone: stiffness0.10.10.4-0.6-0.2-0.30.2
Tibialis anterior weight2.48.19.83.02.6-3.12.7
Time to tail flick, vehicle, before self-admin0.10.10.30.00.50.50.3
Time to tail flick, vehicle, after self-admin0.10.20.3-0.3-0.00.4-0.6
Time to tail flick, test, before self-admin0.20.20.60.3-0.4-0.30.8
Time to tail flick, test, after self-admin0.00.00.10.2-0.30.00.1
Delta time to tail flick, vehicle, before/after SA0.20.20.80.00.2-0.90.1
Delta time to tail flick, test, before/after SA0.20.20.30.40.40.1-0.6
Tibia length0.20.71.6-1.30.31.00.1
Ambulatory time before self-admin1.31.92.71.51.3-1.60.9
Ambulatory time after self-admin0.60.71.90.51.4-0.40.6
Bone: tissue strength0.60.60.9-1.0-0.60.8-0.6
Total heroin consumption1.41.72.40.81.5-1.21.5
Bone: trabecular number0.20.30.5-0.3-0.70.7-0.3
Bone: trabecular spacing0.10.20.5-0.40.30.10.7
Bone: trabecular thickness0.20.30.70.4-0.80.2-0.5
Bone: trabecular tissue density0.20.30.60.20.3-0.7-0.7
Water consumed over 24 hours0.30.40.70.60.9-0.00.7
Number of responses in last shaping day5.45.99.22.22.0-3.02.3