Hub : Genes

Dnal4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Dnal4 0.13 0.06 1.4e-09 0.1 0.11 0.12 0.12 2.8e-08 2.3e-09 3.1e-10 1.2e-09
2 Adipose gene expression Dnal4 0.13 0.05 1.5e-15 0.14 0.13 0.13 0.14 4.4e-15 7.5e-14 1.7e-14 9.8e-15
3 IL gene expression Dnal4 0.21 0.1 2.1e-03 0.05 0.04 -0.01 0.02 2.0e-02 3.2e-02 6.9e-01 9.9e-02
4 Liver gene expression Dnal4 0.12 0.05 4.2e-14 0.12 0.12 0.12 0.12 5.4e-13 7.1e-13 4.7e-13 5.3e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.10.10.2-0.5-0.30.5-0.2
Area under the delay curve3.55.35.7-2.4-2.22.2-2.4
BMI with tail0.93.14.21.82.0-1.41.8
BMI without tail0.31.72.31.21.0-1.51.5
Body weight2.19.410.23.22.7-3.23.2
Weight adjusted by age0.20.61.50.90.2-1.20.5
Bone surface0.20.40.9-0.6-1.00.2-0.7
Bone volume0.10.10.3-0.5-0.30.1-0.4
Breakpoint value in progressive ratio session0.00.10.1-0.3-0.30.1-0.2
Number of licking bursts0.31.01.5-1.2-1.20.6-0.9
Context. condit. distance diff. score8.510.313.42.73.3-3.73.1
Locomotion velocity, session 10.80.92.10.2-1.50.2-1.1
Locomotion distance, session 15.87.412.1-2.4-3.51.7-3.0
Locomotion velocity, session 20.10.10.40.60.10.1-0.4
Locomotion distance, session 27.510.614.5-2.7-3.83.0-3.4
Locomotion velocity, session 32.12.53.91.51.3-2.01.4
Locomotion distance, session 30.30.40.7-0.7-0.4-0.9-0.3
Stereotopy head waving bouts, day 30.10.20.50.70.20.10.4
Stereotopy head waving duration, day 31.82.24.32.11.4-0.71.4
Locomotion velocity, session 70.80.91.90.41.4-1.10.7
Locomotion distance, session 70.20.20.6-0.80.0-0.2-0.4
Stereotopy head waving bouts, day 75.46.28.32.92.7-2.22.1
Stereotopy head waving duration, day 75.16.28.42.82.9-1.72.4
Locomotion velocity, session 82.02.44.12.01.3-1.80.8
Locomotion distance, session 80.50.71.60.80.6-1.30.7
Degree of sensitization distance0.60.71.50.81.20.10.7
Degree of sensitization stereotypy4.55.07.12.72.4-2.01.7
Conditioned locomotion0.50.60.70.90.8-0.70.6
Cocaine response after cond. corrected0.10.10.40.3-0.20.4-0.6
Cocaine response after cond. not corrected0.10.10.20.3-0.00.4-0.4
Cocaine response before conditioning0.10.10.1-0.20.10.10.4
Saline control response0.70.91.30.91.1-0.81.0
Bone: connectivity density0.00.00.1-0.0-0.1-0.30.1
Bone: cortical apparent density0.20.40.70.10.7-0.40.9
Bone: cortical area0.10.20.30.60.30.3-0.3
Bone: cortical porosity0.50.51.11.01.0-0.10.1
Bone: cortical porosity1.01.12.41.61.3-0.40.2
Bone: cortical thickness0.50.81.4-0.7-0.31.2-1.1
Bone: cortical thickness2.12.64.2-1.3-1.71.3-2.1
Bone: cortical tissue density0.20.40.70.20.7-0.50.8
Condit. Reinf. active minus inactive responses0.30.30.6-0.7-0.60.8-0.2
Condit. Reinf. active-inactive response ratio0.10.10.30.10.5-0.10.5
Condit. Reinf. active responses0.60.81.4-1.2-0.91.00.0
Condit. Reinf. inactive responses0.60.71.8-1.3-0.90.60.2
Incentive salience index mean0.40.60.9-0.9-0.70.9-0.4
Condit. Reinf. lever presses0.30.40.7-0.8-0.40.8-0.2
Condit. Reinf. active minus inactive responses0.91.42.4-0.9-1.60.7-1.4
Condit. Reinf. active-inactive response ratio0.30.41.0-0.2-1.00.3-0.8
Condit. Reinf. active responses0.40.61.1-0.5-1.00.2-0.9
Condit. Reinf. inactive responses0.10.20.4-0.4-0.2-0.0-0.6
Condit. Reinf. lever presses0.60.81.6-1.3-1.00.8-0.1
Condit. Reinf. lever reinforcers received0.40.51.0-0.5-1.00.4-0.8
Conditioned reinforcement - actives0.83.05.0-1.6-1.91.1-2.2
Conditioned reinforcement - inactives1.95.36.5-2.4-2.61.9-2.3
Conditioned locomotion1.42.12.6-1.0-1.61.6-1.6
Patch foraging indifference point 0 sec0.10.20.5-0.2-0.10.70.5
Patch foraging indifference point AUC1.53.75.3-1.9-2.01.3-2.3
Delay disc. indifference point, 0s delay0.20.31.00.20.11.00.0
Delay disc. indifference point, 16s delay3.95.56.2-2.3-2.52.2-2.4
Delay disc. indifference point, 2s delay5.76.47.6-2.2-2.42.8-2.7
Delay disc. indifference point, 24s delay0.71.12.0-0.7-1.30.1-1.4
Delay disc. indifference point, 4s delay2.62.83.3-1.4-1.71.8-1.7
Delay disc. indifference point, 8s delay2.44.06.5-2.5-1.81.8-1.8
Indifference point function ln k1.64.96.12.32.3-1.72.5
Indifference point function log k1.64.96.12.32.3-1.72.5
Patch foraging total patch changes 0 sec0.20.51.5-0.6-0.41.20.3
Patch foraging total patch changes 12 sec0.50.61.2-0.4-0.61.1-0.8
Patch foraging total patch changes 18 sec0.71.72.4-1.1-1.31.5-1.2
Patch foraging total patch changes 24 sec0.31.01.8-1.4-0.51.1-0.8
Patch foraging total patch changes 6 sec1.52.53.6-1.4-1.51.9-1.6
Patch foraging time to switch 0 sec0.00.10.20.40.40.3-0.1
Patch foraging water rate 0 sec0.00.10.2-0.1-0.3-0.10.4
Patch foraging water rate 12 sec0.10.31.00.30.20.21.0
Patch foraging water rate 18 sec0.10.10.20.5-0.20.10.4
Patch foraging water rate 24 sec1.92.74.61.71.4-1.12.2
Patch foraging water rate 6 sec0.30.51.00.10.5-0.71.0
Seeking ratio, delayed vs. immediate footshock0.10.20.3-0.6-0.30.4-0.3
Distance traveled before self-admin1.32.84.7-1.6-1.62.2-1.3
Distance traveled after self-admin0.30.61.2-0.5-1.10.7-0.7
Extensor digitorum longus weight0.52.03.9-1.0-1.32.0-1.2
Bone: elastic displacement0.40.50.90.90.2-0.60.8
Bone: elastic work0.50.62.31.50.4-0.10.2
Bone: endosteal estimation0.20.41.31.10.3-0.50.3
Bone: endosteal perimeter0.61.53.51.91.1-1.10.5
Epididymis fat weight2.010.011.83.23.4-3.12.9
Delta time in closed arm before/after self-admin1.01.01.5-0.6-1.01.0-1.2
Delta time in open arm before/after self-admin0.10.10.3-0.2-0.50.1-0.1
Diff in mean of infusions in LGA sessions0.10.30.7-0.1-0.5-0.8-0.2
Delay discount exponential model param3.95.25.72.42.3-2.22.3
Extinction: sum of active levers before priming0.71.02.0-0.6-1.00.9-1.4
Active lever presses in extinction session 60.10.10.20.0-0.2-0.1-0.4
Bone: final force0.10.10.20.4-0.10.3-0.5
Bone: final moment0.10.10.20.5-0.20.3-0.5
Food consumed during 24 hour testing period0.10.10.30.60.20.1-0.4
Glucose0.10.10.20.10.3-0.40.4
Heart weight1.93.15.12.31.7-1.21.7
Delay discount hyperbolic model param4.35.56.02.52.3-2.32.4
Intermittent access intake day 1-15 change0.00.10.20.1-0.2-0.40.4
Intermittent access intake escalation0.00.10.1-0.0-0.3-0.40.4
Intermittent access intake escalation 20.00.10.2-0.1-0.1-0.30.4
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.1-0.10.2
Intermitt. access day 15 inactive lever presses0.20.81.3-1.1-1.10.4-0.9
Intermitt. access escalation Index0.00.10.2-0.40.40.2-0.2
Intermittent access day 1 total infusions1.33.96.1-1.5-1.91.8-2.5
Intermittent access day 15 total infusions1.12.84.0-1.5-2.01.4-1.8
Intermittent access terminal intake (last 3 days)1.62.73.7-1.4-1.91.4-1.8
Intermittent access total infusions4.85.78.0-2.0-2.52.2-2.8
Intermittent access day 1 locomotion1.63.03.8-1.7-1.72.0-1.6
Intermittent access day 15 total locomotion0.20.71.0-0.8-1.00.6-1.0
Intermittent access total locomotion0.70.81.1-0.9-0.80.8-1.1
Intermittent access standard deviation0.21.01.5-0.6-1.11.2-1.0
Left kidney weight2.520.032.15.74.3-4.33.2
Right kidney weight3.725.739.26.34.7-5.04.1
Cocaine induced anxiety0.30.91.01.01.0-1.00.9
Post-drug Anxiety1.41.62.11.01.2-1.51.4
Baseline Anxiety0.30.50.8-0.9-0.80.5-0.7
Tail length0.31.83.10.80.6-1.81.7
Length with tail1.56.79.62.61.8-3.12.7
Length without tail1.05.38.42.92.0-2.02.2
Times rat made contact with spout0.50.50.9-0.9-0.9-0.2-0.7
Lifetime Intake5.16.39.3-2.0-2.42.4-3.1
Liver weight, left1.01.72.61.01.5-1.60.8
Liver weight, right7.413.016.13.13.7-4.03.5
Locomotor activity1.52.34.12.01.4-1.41.2
Locomotor testing distance0.00.10.20.10.4-0.20.1
Locomotor testing rearing0.31.02.01.21.4-0.60.4
Locomotion in novel chamber0.10.10.3-0.6-0.1-0.20.3
Locomotion in novel chamber post-restriction0.31.01.3-1.1-0.80.8-1.1
Fecal boli incidents, locomotor time 10.51.21.9-0.9-0.91.2-1.4
Change in fecal boli incidents, locomotor task2.02.24.31.51.2-2.10.9
Time >=10cm from walls, locomotor time 10.30.41.21.10.1-0.50.2
Bouts of movement, locomotor time 10.40.50.80.70.8-0.90.2
Total resting periods, locomotor time 10.10.10.10.30.3-0.3-0.1
Rest time, locomotor task time 10.10.10.50.20.7-0.1-0.1
Distance moved, locomotor task time 10.30.81.40.90.6-0.91.2
Vertical activity count, locomotor time 10.11.01.60.60.9-1.11.3
Time >=10cm from walls, locomotor time 20.20.40.80.90.4-0.50.7
Bouts of movement, locomotor time 20.00.20.3-0.30.60.4-0.3
Total resting periods, locomotor time 20.10.30.6-0.50.10.7-0.8
Rest time, locomotor task time 20.30.40.9-0.6-0.60.3-1.0
Distance moved, locomotor task time 20.81.11.71.00.9-0.81.3
Vertical activity count, locomotor time 20.61.31.60.91.2-1.21.3
Light reinforcement 10.10.30.9-0.0-0.40.9-0.2
Light reinforcement 20.61.43.11.11.8-0.60.9
Bone: marrow area0.20.41.41.20.3-0.50.3
Bone: maximum diameter0.61.33.82.01.0-0.50.3
Bone: maximum force0.20.30.80.4-0.20.4-0.9
Bone: maximum moment0.20.30.70.6-0.20.3-0.8
Mean time between licks in bursts0.10.82.2-0.4-0.81.5-0.5
Mean num. licks in bursts0.30.71.30.70.8-1.10.6
Cd content in liver0.40.41.01.0-0.0-0.90.1
Co content in liver1.11.31.6-0.9-1.31.3-1.2
Cu content in liver3.84.66.6-2.5-2.61.8-1.5
Fe content in liver2.63.27.12.71.2-1.31.6
K content in liver0.20.20.5-0.6-0.7-0.2-0.3
Mg content in liver0.30.30.6-0.6-0.8-0.3-0.4
Mn content in liver0.10.10.1-0.20.4-0.3-0.1
Na content in liver0.10.10.2-0.4-0.40.0-0.0
Rb content in liver0.70.81.2-0.7-1.00.7-1.1
Se content in liver0.20.30.50.7-0.2-0.50.7
Sr content in liver2.21.94.9-2.2-0.91.1-0.8
Zn content in liver0.20.30.6-0.3-0.8-0.50.0
Bone: minimum diameter0.00.10.20.30.30.0-0.4
Time in familiar zone, hab. session 10.30.30.7-0.3-0.80.2-0.8
Time in novel zone, hab. session 11.41.62.31.51.2-0.71.4
Total zone transitions, hab. session 11.11.53.3-1.4-1.80.2-0.8
Total locomotion distance, hab. session 10.20.30.4-0.6-0.6-0.60.2
Locomotion velocity, hab. session 10.50.81.6-1.2-1.2-0.2-0.3
Time in familiar zone, hab. session 20.20.20.6-0.10.1-0.80.6
Time in novel zone, hab. session 20.20.20.6-0.1-0.20.5-0.8
Total zone transitions, hab. session 22.63.35.9-1.5-2.41.3-1.8
Total locomotion distance, hab. session 22.02.74.0-1.3-2.01.6-1.6
Locomotion velocity, hab. session 22.63.55.3-1.6-2.31.8-1.8
Novel to familiar place preference ratio2.63.45.32.31.3-2.01.6
Novelty place preference3.74.76.82.61.7-2.41.9
Time in novel zone, NPP test4.55.57.62.71.7-2.62.1
Total zone transitions, NPP test2.33.46.4-1.8-2.51.0-1.7
Total locomotion distance, NPP test1.31.93.2-1.3-1.81.1-1.2
Locomotion velocity, NPP test1.92.73.3-1.7-1.81.6-1.5
Intraocular pressure0.40.61.11.00.6-0.80.6
Delta distance traveled before/after self-admin1.82.03.91.51.0-2.00.8
Delta ambulatory time before/after self-admin0.71.22.61.40.5-1.60.4
Parametrial fat weight1.33.04.31.22.1-1.71.8
Pavlov. Cond. lever latency0.10.10.30.20.0-0.50.1
Pavlov. Cond. magazine entry latency1.21.62.4-1.1-1.01.3-1.5
Pavlov. Cond. change in total contacts3.23.44.3-1.8-1.52.1-2.0
Pavlov. Cond. index score0.60.71.1-0.8-0.61.0-1.0
Pavlov. Cond. latency score0.30.30.6-0.5-0.30.8-0.7
Pavlov. Cond. lever contacts0.60.71.1-1.1-0.41.0-0.7
Pavlov. Cond. magazine entry number1.62.02.61.51.2-1.31.6
Pavlov. Cond. intertrial magazine entries0.80.92.1-0.9-1.40.9-0.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.0-0.9-0.60.9-1.0
Pavlov. Cond. response bias1.31.61.8-1.4-1.01.3-1.3
Pavlov. Cond. lever latency0.20.30.50.50.4-0.7-0.5
Pavlov. Cond. magazine entry latency2.33.34.3-1.8-2.12.0-1.3
Pavlov. Cond. change in total contacts0.10.30.70.3-0.80.80.1
Pavlov. Cond. index score0.71.11.7-1.0-1.31.3-0.3
Pavlov. Cond. latency score1.01.52.3-1.2-1.51.4-0.5
Pavlov. Cond. lever contacts0.20.30.5-0.4-0.40.70.6
Pavlov. Cond. magazine entry number0.60.81.30.81.1-1.00.5
Pavlov. Cond. intertrial magazine entries0.10.30.6-0.10.5-0.4-0.8
Pavlov. Cond. lever-magazine prob. diff.0.71.01.7-0.9-1.21.3-0.3
Pavlov. Cond. response bias0.50.71.3-0.8-0.81.2-0.1
Time in closed arm before self-admin0.50.92.4-1.0-0.41.5-0.3
Time in closed arm after self-admin0.10.10.3-0.10.50.2-0.3
Time in open arm before self-admin0.20.30.70.10.2-0.80.7
Time in open arm after self-admin0.20.20.5-0.2-0.2-0.50.7
Bone: periosteal estimation0.20.41.31.10.4-0.1-0.0
Bone: periosteal perimeter1.12.15.02.21.2-1.20.7
Bone: post-yield work0.81.32.2-0.6-1.40.8-1.5
Progressive ratio test 1 active lever presses2.64.66.3-1.6-2.32.0-2.5
Progressive ratio test 1 breakpoint2.54.46.1-1.6-2.21.9-2.5
Progressive ratio test 1 inactive lever presses1.94.96.7-2.0-2.02.6-2.3
Progressive ratio test 2 active lever presses2.84.07.1-1.9-1.81.4-2.7
Progressive ratio test 2 breakpoint3.54.47.9-2.0-1.91.5-2.8
Progressive ratio test 2 inactive lever presses1.23.95.6-2.4-1.91.3-2.2
Incentive Sensitization - Responses0.20.61.2-1.0-0.40.1-1.1
Incentive Sensitization - Breakpoint0.20.51.2-0.9-0.30.0-1.1
Sum of active levers in priming session hrs 5-60.10.10.10.1-0.1-0.40.3
Progressive ratio0.00.10.2-0.2-0.50.5-0.0
Food seeking constrained by brief footshock0.10.20.30.1-0.30.5-0.5
Seeking ratio, punishment vs. effort0.00.10.20.20.20.2-0.5
Retroperitoneal fat weight3.415.420.34.34.5-3.43.3
Reaction time number correct0.10.20.7-0.10.3-0.90.1
Reaction time mean minus median0.00.00.00.2-0.0-0.2-0.1
Reaction time mean minus median AUC0.10.60.80.70.9-0.90.5
Reaction time num false alarms0.20.40.90.60.3-0.30.9
Reaction time num false alarms AUC0.10.30.80.50.3-0.20.9
Reaction time trials correct on left0.10.20.7-0.10.3-0.90.1
Reaction time trials on left0.10.20.7-0.10.3-0.80.0
Reaction time mean0.10.20.40.40.4-0.60.3
Reaction time mean AUC0.10.20.50.30.4-0.70.1
Median of all reaction times0.10.10.30.30.4-0.60.2
Reaction time omissions0.50.92.4-0.8-0.50.5-1.5
Reaction time false alarm rate0.20.20.60.50.30.10.8
Reaction time premature initiation rate0.20.30.90.0-0.10.6-0.9
Reaction time premature initiations0.00.10.50.00.2-0.0-0.7
Std. dev. reaction times0.20.71.00.90.8-1.00.5
Reaction time trials completed0.10.20.7-0.10.3-0.80.0
Reaction time trials AUC0.10.30.80.10.5-0.90.2
Run reversals in cocaine runway, females0.80.91.40.91.0-0.71.2
Run reversals in cocaine runway, males0.40.51.0-0.1-1.0-0.5-0.9
Latency to leave start box in cocaine runway0.40.51.31.10.8-0.30.5
Latency to leave start box in cocaine runway, F0.20.30.70.2-0.50.9-0.3
Latency to leave start box in cocaine runway, M3.13.03.91.62.0-1.91.4
Std. dev. time between licks in bursts0.40.81.4-0.7-1.21.1-0.4
Total sessions with >9 infusions1.31.63.0-0.7-0.91.4-1.7
Short access day 1 total inactive lever presses1.22.44.2-0.9-2.11.6-1.5
Short access day 10 total inactive lever presses0.21.21.70.61.1-1.31.1
Short access day 1 total infusions0.61.11.5-1.0-0.91.2-1.1
Short access day 10 total infusions0.81.32.4-0.6-0.81.4-1.5
Short access total infusions2.33.35.4-1.3-1.52.0-2.3
Short access day 1 locomotion0.30.40.7-0.6-0.60.8-0.6
Short access day 10 total locomotion0.31.22.3-1.5-0.51.4-0.4
Short access total locomotion0.71.02.4-0.9-0.51.6-0.8
One hour access (0.3 mA shock)6.88.09.6-2.7-2.82.7-3.1
Compulsive drug intake0.40.51.0-0.9-0.5-0.2-1.0
One hour access (shock baseline)1.02.64.5-1.2-1.62.1-1.4
Social response proportion0.40.51.31.1-0.30.9-0.0
Social responses1.01.32.4-0.2-1.31.6-1.0
Social time2.94.65.9-1.9-2.32.4-2.0
Soleus weight0.41.22.1-1.4-0.90.5-1.4
Bone: stiffness0.10.10.40.60.20.3-0.2
Tibialis anterior weight2.48.19.8-3.0-2.63.1-2.7
Time to tail flick, vehicle, before self-admin0.10.10.3-0.0-0.5-0.5-0.3
Time to tail flick, vehicle, after self-admin0.10.20.30.30.0-0.40.6
Time to tail flick, test, before self-admin0.20.20.6-0.30.40.3-0.8
Time to tail flick, test, after self-admin0.00.00.1-0.20.3-0.0-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.8-0.0-0.20.9-0.1
Delta time to tail flick, test, before/after SA0.10.20.3-0.4-0.4-0.10.6
Tibia length0.20.71.61.3-0.3-1.0-0.1
Ambulatory time before self-admin0.61.92.7-1.5-1.31.6-0.9
Ambulatory time after self-admin0.40.71.9-0.5-1.40.4-0.6
Bone: tissue strength0.50.60.91.00.6-0.80.6
Total heroin consumption1.41.72.4-0.8-1.51.2-1.5
Bone: trabecular number0.20.30.50.30.7-0.70.3
Bone: trabecular spacing0.10.20.50.4-0.3-0.1-0.7
Bone: trabecular thickness0.20.30.7-0.40.8-0.20.5
Bone: trabecular tissue density0.20.30.6-0.2-0.30.70.7
Water consumed over 24 hours0.20.40.7-0.6-0.90.0-0.7
Number of responses in last shaping day4.65.99.2-2.2-2.03.0-2.3