Hub : Genes

Dnaaf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Dnaaf3 0.22 0.14 4.6e-04 0.06 0.1 -0.01 0.11 1.3e-02 2.1e-03 8.1e-01 1.8e-03
2 PL gene expression Dnaaf3 0.03 0.03 1.2e-03 0.01 0.01 0.01 0.01 1.2e-02 1.1e-02 2.7e-02 1.1e-02
3 IL alternative TSS NM_001271115.1 0.16 0.12 3.8e-03 0.06 0.13 0.08 0.11 1.4e-02 5.1e-04 6.0e-03 1.5e-03
4 IL alternative TSS XM_039101524.2 0.19 0.13 2.3e-03 0.02 0.13 0.04 0.1 1.3e-01 4.5e-04 3.9e-02 2.6e-03
5 Brain gene expression Dnaaf3 0.13 0.08 7.2e-12 0.13 0.12 0.12 0.12 3.9e-12 1.3e-11 5.7e-11 4.4e-11
6 NAcc gene expression Dnaaf3 0.03 0.02 2.4e-04 0.02 0.02 0.02 0.02 2.3e-04 1.3e-04 7.3e-04 1.7e-04
7 PL isoform ratio XM_017588635.3 0.05 0.04 4.1e-03 0.02 0.03 0.03 0.03 4.2e-03 5.2e-04 4.7e-04 7.6e-04
8 PL isoform ratio XM_039101524.2 0.04 0.04 8.0e-03 0 0.02 0.02 0.02 9.0e-02 1.3e-03 4.2e-03 2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.2-0.30.4-0.20.10.4-0.4-0.4-0.3
Area under the delay curve0.20.30.40.7-0.60.6-0.5-0.50.5-0.60.2
BMI with tail0.41.52.21.4-1.40.9-0.8-1.51.41.00.9
BMI without tail0.00.30.7-0.50.4-0.80.8-0.0-0.0-0.10.7
Body weight1.04.37.7-2.32.2-2.82.81.6-1.5-1.80.4
Weight adjusted by age0.30.81.5-0.71.0-0.40.21.2-1.2-0.6-1.2
Bone surface2.14.26.1-2.52.4-2.42.32.1-2.0-1.3-0.4
Bone volume1.73.34.6-2.12.1-2.02.01.9-1.8-1.6-0.5
Breakpoint value in progressive ratio session0.20.40.70.8-0.70.6-0.6-0.60.60.50.2
Number of licking bursts0.00.10.10.3-0.30.3-0.3-0.20.20.40.1
Context. condit. distance diff. score0.20.30.80.4-0.20.6-0.6-0.1-0.00.9-0.5
Locomotion velocity, session 12.02.27.40.40.11.6-1.91.0-1.11.3-2.7
Locomotion distance, session 12.02.65.5-1.41.7-0.50.22.2-2.3-0.3-2.3
Locomotion velocity, session 20.60.72.20.6-0.31.1-1.30.4-0.40.2-1.5
Locomotion distance, session 21.52.13.5-1.51.7-0.80.61.8-1.9-1.1-1.6
Locomotion velocity, session 30.10.20.60.3-0.20.5-0.5-0.0-0.0-0.7-0.4
Locomotion distance, session 30.30.41.2-0.30.40.2-0.30.8-0.8-0.4-1.1
Stereotopy head waving bouts, day 30.50.64.00.3-0.40.2-0.1-0.40.42.00.4
Stereotopy head waving duration, day 30.40.52.70.3-0.40.1-0.0-0.50.51.60.6
Locomotion velocity, session 70.20.20.7-0.10.30.3-0.40.4-0.50.4-0.8
Locomotion distance, session 70.30.31.20.10.20.6-0.70.4-0.50.5-1.1
Stereotopy head waving bouts, day 70.30.30.9-0.50.3-0.70.70.2-0.10.90.4
Stereotopy head waving duration, day 70.20.20.5-0.50.3-0.70.70.2-0.10.50.4
Locomotion velocity, session 80.50.61.80.30.00.9-1.00.4-0.51.0-1.4
Locomotion distance, session 80.30.51.6-0.30.60.3-0.40.7-0.90.4-1.3
Degree of sensitization distance0.10.10.6-0.10.10.0-0.00.0-0.10.8-0.1
Degree of sensitization stereotypy0.10.10.3-0.20.0-0.40.5-0.10.10.40.5
Conditioned locomotion0.30.30.80.10.20.3-0.40.5-0.50.9-0.9
Cocaine response after cond. corrected1.42.13.91.3-1.50.4-0.2-1.91.9-1.12.0
Cocaine response after cond. not corrected0.50.72.9-0.30.1-0.80.9-0.30.4-1.71.1
Cocaine response before conditioning5.46.510.1-3.13.2-2.42.13.1-3.1-0.6-1.7
Saline control response0.50.72.80.30.10.8-0.90.8-0.80.4-1.7
Bone: connectivity density0.00.10.10.3-0.20.2-0.2-0.20.2-0.40.1
Bone: cortical apparent density0.40.62.40.00.20.4-0.60.6-0.6-1.6-1.1
Bone: cortical area0.61.01.6-1.31.2-1.21.21.0-1.0-0.0-0.2
Bone: cortical porosity0.60.60.90.8-0.80.5-0.4-0.91.00.90.8
Bone: cortical porosity0.30.41.00.3-0.4-0.10.2-0.70.70.81.0
Bone: cortical thickness0.40.61.20.8-0.71.0-1.0-0.50.41.1-0.4
Bone: cortical thickness0.20.20.6-0.20.40.1-0.10.6-0.6-0.3-0.8
Bone: cortical tissue density0.40.62.80.00.20.4-0.50.6-0.5-1.7-1.0
Condit. Reinf. active minus inactive responses0.30.30.90.5-0.50.4-0.3-0.50.5-0.90.3
Condit. Reinf. active-inactive response ratio1.31.42.11.4-1.41.0-0.9-1.41.4-0.70.8
Condit. Reinf. active responses0.00.10.1-0.30.3-0.30.30.3-0.2-0.0-0.0
Condit. Reinf. inactive responses2.22.94.3-2.02.1-1.51.32.0-2.01.0-1.2
Incentive salience index mean0.20.32.1-0.20.3-0.20.20.2-0.2-1.4-0.1
Condit. Reinf. lever presses0.71.12.6-1.01.1-0.80.81.0-1.0-1.6-0.5
Condit. Reinf. active minus inactive responses2.43.65.6-2.32.4-2.01.92.2-2.2-0.2-1.0
Condit. Reinf. active-inactive response ratio3.15.08.1-2.82.7-2.72.62.2-2.2-0.9-0.3
Condit. Reinf. active responses2.33.25.3-2.12.2-1.51.32.2-2.30.7-1.5
Condit. Reinf. inactive responses0.30.42.20.00.10.4-0.40.4-0.51.5-0.8
Condit. Reinf. lever presses0.60.92.3-1.00.8-1.51.50.3-0.30.31.0
Condit. Reinf. lever reinforcers received2.94.16.5-2.42.5-1.71.52.5-2.60.6-1.6
Conditioned reinforcement - actives0.20.62.5-0.60.6-0.90.90.2-0.1-1.60.5
Conditioned reinforcement - inactives0.92.63.7-1.81.9-1.51.41.8-1.8-1.3-0.9
Conditioned locomotion0.20.20.6-0.40.4-0.60.60.1-0.0-0.70.5
Patch foraging indifference point 0 sec0.20.61.60.9-0.61.2-1.2-0.40.20.0-0.8
Patch foraging indifference point AUC0.30.70.90.9-1.00.8-0.8-0.80.90.90.4
Delay disc. indifference point, 0s delay0.40.51.90.30.00.7-0.90.6-0.60.1-1.4
Delay disc. indifference point, 16s delay0.71.02.90.6-0.90.00.2-1.41.4-0.11.7
Delay disc. indifference point, 2s delay0.50.61.00.9-0.71.0-1.0-0.30.4-1.0-0.4
Delay disc. indifference point, 24s delay0.40.71.30.7-0.90.4-0.2-1.11.1-0.41.0
Delay disc. indifference point, 4s delay0.20.21.4-0.30.3-0.40.40.2-0.1-1.20.2
Delay disc. indifference point, 8s delay0.00.10.20.3-0.30.4-0.4-0.10.2-0.2-0.2
Indifference point function ln k2.05.99.5-2.83.0-2.01.83.0-3.1-1.0-2.0
Indifference point function log k2.05.99.5-2.83.0-2.01.83.0-3.1-1.0-2.0
Patch foraging total patch changes 0 sec0.20.61.40.9-0.61.1-1.2-0.30.20.1-0.8
Patch foraging total patch changes 12 sec0.20.30.50.5-0.60.4-0.3-0.70.7-0.30.5
Patch foraging total patch changes 18 sec0.20.61.11.0-0.90.9-0.9-0.70.7-0.20.0
Patch foraging total patch changes 24 sec0.10.41.1-0.2-0.1-0.50.6-0.40.4-1.01.0
Patch foraging total patch changes 6 sec0.61.01.41.1-1.21.1-1.0-1.11.10.50.4
Patch foraging time to switch 0 sec1.45.213.61.5-2.10.00.4-3.03.1-1.63.7
Patch foraging water rate 0 sec0.41.43.5-0.81.00.0-0.21.5-1.51.0-1.9
Patch foraging water rate 12 sec0.83.46.9-1.72.0-0.60.32.6-2.50.2-2.6
Patch foraging water rate 18 sec0.71.63.3-1.01.2-0.20.01.7-1.71.2-1.8
Patch foraging water rate 24 sec0.81.12.2-1.01.2-0.40.21.4-1.50.4-1.4
Patch foraging water rate 6 sec4.36.39.0-3.02.9-2.72.52.8-2.7-1.6-1.0
Seeking ratio, delayed vs. immediate footshock0.60.92.90.20.30.7-0.90.9-0.91.2-1.7
Distance traveled before self-admin1.53.29.1-1.01.6-0.0-0.32.6-2.50.0-3.0
Distance traveled after self-admin1.01.74.50.9-0.41.5-1.60.4-0.42.1-1.7
Extensor digitorum longus weight0.20.92.1-1.10.9-1.41.50.5-0.4-0.60.7
Bone: elastic displacement0.81.04.50.7-0.61.0-1.0-0.30.32.1-0.4
Bone: elastic work0.40.51.0-0.80.9-0.40.31.0-1.00.5-0.8
Bone: endosteal estimation2.25.48.7-2.92.7-3.02.92.1-2.0-1.60.0
Bone: endosteal perimeter1.33.25.0-2.22.1-2.22.11.7-1.7-0.9-0.2
Epididymis fat weight0.21.14.2-0.3-0.2-1.11.3-0.90.9-0.52.0
Delta time in closed arm before/after self-admin0.00.00.1-0.0-0.20.3-0.3-0.20.2-0.10.0
Delta time in open arm before/after self-admin1.11.32.3-1.11.4-0.80.71.5-1.50.8-1.1
Diff in mean of infusions in LGA sessions0.20.41.40.00.30.5-0.60.8-0.6-0.3-1.2
Delay discount exponential model param0.20.20.5-0.50.5-0.40.40.4-0.40.7-0.2
Extinction: sum of active levers before priming0.20.20.60.4-0.30.6-0.6-0.1-0.10.8-0.5
Active lever presses in extinction session 60.80.83.00.1-0.3-0.70.8-1.01.00.11.7
Bone: final force1.83.04.3-2.12.0-1.91.81.8-1.7-1.5-0.5
Bone: final moment2.33.75.3-2.32.3-2.01.92.1-2.1-1.6-0.8
Food consumed during 24 hour testing period0.91.82.8-1.61.7-1.41.41.5-1.4-0.9-0.5
Glucose1.42.23.81.7-1.62.0-2.0-1.21.11.5-0.4
Heart weight1.22.03.5-1.71.5-1.91.91.0-0.9-1.40.4
Delay discount hyperbolic model param0.20.30.7-0.60.5-0.50.50.4-0.50.8-0.1
Intermittent access intake day 1-15 change0.10.71.0-0.81.0-1.01.00.9-0.9-0.8-0.2
Intermittent access intake escalation0.21.21.9-1.11.2-1.41.41.0-1.0-1.1-0.1
Intermittent access intake escalation 20.20.30.9-0.10.30.1-0.20.7-0.70.1-0.9
Intermitt. access day 1 inactive lever presses0.11.63.0-1.51.4-1.71.70.9-1.0-0.90.3
Intermitt. access day 15 inactive lever presses0.52.95.1-2.32.0-2.32.31.2-1.2-0.70.4
Intermitt. access escalation Index0.10.41.01.0-0.70.6-0.6-0.70.70.50.2
Intermittent access day 1 total infusions0.20.61.1-0.80.8-1.11.10.5-0.4-0.80.3
Intermittent access day 15 total infusions0.51.22.4-1.01.1-1.51.60.7-0.7-1.20.5
Intermittent access terminal intake (last 3 days)0.61.01.8-0.91.0-1.31.30.8-0.7-1.20.2
Intermittent access total infusions1.31.62.5-1.31.3-1.61.60.9-0.9-1.60.2
Intermittent access day 1 locomotion0.71.31.9-1.11.3-1.41.31.0-0.9-1.4-0.0
Intermittent access day 15 total locomotion0.41.53.0-0.91.4-0.90.71.7-1.7-0.7-1.3
Intermittent access total locomotion2.53.04.2-1.72.1-1.91.81.9-1.8-1.8-0.6
Intermittent access standard deviation0.00.20.70.8-0.60.6-0.6-0.30.30.1-0.1
Left kidney weight2.318.627.7-5.35.2-5.14.94.5-4.3-2.2-1.0
Right kidney weight2.718.829.7-5.45.1-5.45.34.1-4.0-2.2-0.2
Cocaine induced anxiety0.30.91.4-1.11.2-1.01.01.0-1.00.3-0.4
Post-drug Anxiety0.50.51.2-0.80.6-1.11.10.3-0.30.70.6
Baseline Anxiety0.30.61.00.9-1.00.6-0.6-1.00.90.10.6
Tail length1.910.014.6-3.83.7-3.63.53.2-3.1-2.5-0.7
Length with tail2.611.317.4-3.93.7-4.24.13.0-2.8-3.30.1
Length without tail0.94.910.2-2.32.1-3.13.21.2-1.0-2.41.3
Times rat made contact with spout0.10.10.40.2-0.2-0.10.1-0.50.5-0.10.6
Lifetime Intake0.91.12.1-1.11.1-1.31.30.7-0.7-1.50.2
Liver weight, left0.81.42.2-1.51.4-1.51.41.2-1.0-0.7-0.1
Liver weight, right0.00.00.1-0.20.2-0.20.20.0-0.0-0.20.2
Locomotor activity0.10.10.40.2-0.30.00.0-0.60.50.10.6
Locomotor testing distance0.20.41.1-0.40.1-0.70.8-0.40.4-0.51.1
Locomotor testing rearing0.20.71.5-1.00.9-1.21.20.6-0.5-0.60.4
Locomotion in novel chamber0.91.22.81.7-1.31.3-1.3-0.91.00.2-0.0
Locomotion in novel chamber post-restriction0.20.71.20.9-0.90.6-0.5-1.11.0-0.60.6
Fecal boli incidents, locomotor time 10.10.30.5-0.60.6-0.40.40.7-0.7-0.5-0.5
Change in fecal boli incidents, locomotor task2.12.23.51.9-1.81.9-1.8-1.51.40.50.1
Time >=10cm from walls, locomotor time 10.00.10.20.1-0.2-0.00.1-0.40.3-0.10.4
Bouts of movement, locomotor time 10.91.24.2-0.30.60.5-0.71.3-1.40.8-2.0
Total resting periods, locomotor time 10.50.61.90.10.10.7-0.80.6-0.70.7-1.4
Rest time, locomotor task time 10.81.31.9-1.41.2-1.31.21.0-1.1-1.3-0.2
Distance moved, locomotor task time 10.51.52.21.4-1.31.3-1.3-1.11.11.50.2
Vertical activity count, locomotor time 10.53.46.22.2-1.72.4-2.5-0.91.02.2-0.9
Time >=10cm from walls, locomotor time 20.30.81.50.9-1.10.7-0.6-1.21.10.40.7
Bouts of movement, locomotor time 20.00.00.0-0.20.1-0.20.20.0-0.1-0.20.0
Total resting periods, locomotor time 20.00.00.1-0.20.2-0.10.00.2-0.2-0.4-0.2
Rest time, locomotor task time 20.10.20.7-0.00.20.3-0.40.5-0.5-0.1-0.8
Distance moved, locomotor task time 20.20.20.80.5-0.50.4-0.4-0.40.40.90.1
Vertical activity count, locomotor time 20.10.30.80.6-0.40.6-0.6-0.10.20.9-0.3
Light reinforcement 10.21.03.20.6-0.11.2-1.40.6-0.6-0.3-1.8
Light reinforcement 20.81.83.41.7-1.41.8-1.8-0.90.90.7-0.5
Bone: marrow area2.25.58.9-2.92.7-3.02.92.1-2.0-1.50.1
Bone: maximum diameter0.91.73.5-1.61.4-1.91.91.0-0.9-0.60.4
Bone: maximum force2.34.67.0-2.62.5-2.62.52.1-2.0-1.6-0.3
Bone: maximum moment2.85.27.8-2.82.7-2.62.52.3-2.3-1.7-0.6
Mean time between licks in bursts0.20.92.01.0-0.81.3-1.4-0.40.31.2-0.7
Mean num. licks in bursts0.10.30.7-0.40.4-0.70.70.1-0.0-0.80.5
Cd content in liver1.61.82.7-1.61.6-1.31.21.6-1.60.1-0.9
Co content in liver1.01.23.5-0.71.0-0.0-0.21.5-1.5-0.2-1.9
Cu content in liver0.60.71.1-1.01.0-1.01.00.9-0.8-0.5-0.2
Fe content in liver0.20.20.4-0.60.6-0.60.50.5-0.5-0.2-0.2
K content in liver0.00.00.10.1-0.00.1-0.1-0.00.10.4-0.0
Mg content in liver0.20.20.80.3-0.3-0.20.2-0.60.70.10.9
Mn content in liver0.10.20.60.1-0.2-0.30.4-0.40.5-0.10.8
Na content in liver2.32.64.12.0-1.91.8-1.7-1.71.71.10.4
Rb content in liver1.92.24.0-1.81.7-2.02.01.3-1.2-0.70.2
Se content in liver1.92.33.61.5-1.70.9-0.7-1.91.91.51.5
Sr content in liver5.24.59.12.6-2.23.0-3.0-1.31.31.4-1.0
Zn content in liver0.70.82.30.6-0.8-0.10.2-1.21.2-0.11.5
Bone: minimum diameter2.54.77.2-2.72.6-2.52.42.3-2.2-1.0-0.6
Time in familiar zone, hab. session 12.73.05.3-1.82.1-1.00.82.3-2.3-0.8-1.9
Time in novel zone, hab. session 12.22.53.41.8-1.81.4-1.3-1.71.71.70.9
Total zone transitions, hab. session 11.31.86.3-0.50.90.5-0.71.7-1.7-0.3-2.5
Total locomotion distance, hab. session 10.71.03.9-0.20.50.6-0.81.1-1.20.1-2.0
Locomotion velocity, hab. session 10.50.72.7-0.10.40.5-0.70.9-1.0-0.1-1.6
Time in familiar zone, hab. session 22.83.15.6-2.01.8-2.32.41.2-1.1-1.80.6
Time in novel zone, hab. session 21.82.02.91.6-1.51.7-1.7-1.21.11.7-0.1
Total zone transitions, hab. session 21.82.34.3-1.51.7-0.80.62.1-2.1-0.3-1.8
Total locomotion distance, hab. session 20.30.41.70.00.20.6-0.70.6-0.70.1-1.3
Locomotion velocity, hab. session 20.40.62.10.20.10.8-0.90.6-0.60.2-1.4
Novel to familiar place preference ratio0.00.00.1-0.20.1-0.30.40.00.00.10.3
Novelty place preference0.10.10.2-0.40.3-0.50.50.3-0.20.00.1
Time in novel zone, NPP test0.10.20.3-0.50.4-0.60.60.3-0.2-0.10.2
Total zone transitions, NPP test0.40.51.4-0.50.70.0-0.11.0-1.0-0.5-1.2
Total locomotion distance, NPP test0.20.30.5-0.60.7-0.50.40.6-0.7-0.2-0.4
Locomotion velocity, NPP test0.30.40.7-0.60.7-0.30.20.8-0.8-0.1-0.8
Intraocular pressure0.10.20.90.3-0.20.4-0.50.00.0-0.9-0.4
Delta distance traveled before/after self-admin1.71.92.51.6-1.61.3-1.2-1.61.61.20.8
Delta ambulatory time before/after self-admin0.81.41.81.3-1.41.2-1.1-1.31.31.10.5
Parametrial fat weight1.33.14.62.1-2.11.6-1.5-2.12.11.21.1
Pavlov. Cond. lever latency0.10.10.30.4-0.30.5-0.5-0.20.20.3-0.2
Pavlov. Cond. magazine entry latency0.60.71.30.9-1.00.5-0.4-1.21.20.41.0
Pavlov. Cond. change in total contacts0.20.20.40.6-0.60.5-0.5-0.40.4-0.20.1
Pavlov. Cond. index score0.20.20.40.6-0.60.4-0.4-0.60.60.10.4
Pavlov. Cond. latency score0.10.20.30.4-0.50.3-0.2-0.50.5-0.00.4
Pavlov. Cond. lever contacts0.20.30.7-0.50.3-0.80.80.10.0-0.40.7
Pavlov. Cond. magazine entry number0.20.30.5-0.50.6-0.20.20.7-0.70.2-0.7
Pavlov. Cond. intertrial magazine entries1.11.33.30.4-0.11.1-1.30.7-0.71.8-1.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.6-0.70.4-0.4-0.60.60.10.4
Pavlov. Cond. response bias0.20.30.80.0-0.2-0.40.5-0.40.5-0.60.9
Pavlov. Cond. lever latency0.50.73.3-0.70.6-0.60.60.6-0.6-1.8-0.2
Pavlov. Cond. magazine entry latency0.81.13.30.9-1.00.7-0.6-1.11.11.80.8
Pavlov. Cond. change in total contacts0.20.52.8-0.20.4-0.1-0.00.5-0.61.7-0.6
Pavlov. Cond. index score0.30.43.00.3-0.30.1-0.1-0.30.31.70.4
Pavlov. Cond. latency score0.50.83.30.7-0.70.5-0.4-0.70.81.80.5
Pavlov. Cond. lever contacts0.30.43.00.4-0.30.2-0.2-0.30.31.70.2
Pavlov. Cond. magazine entry number0.50.61.9-0.80.8-0.60.50.8-0.8-1.4-0.5
Pavlov. Cond. intertrial magazine entries1.63.54.9-2.22.2-1.91.82.1-2.1-1.3-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.53.40.4-0.40.3-0.3-0.40.41.80.2
Pavlov. Cond. response bias0.30.42.5-0.30.4-0.40.40.2-0.21.60.1
Time in closed arm before self-admin0.40.81.2-0.91.1-1.00.91.0-0.9-0.7-0.3
Time in closed arm after self-admin0.30.41.4-0.50.3-0.60.6-0.00.1-1.20.6
Time in open arm before self-admin1.41.72.71.4-1.61.4-1.3-1.61.50.50.6
Time in open arm after self-admin0.50.62.70.6-0.40.7-0.8-0.10.01.7-0.6
Bone: periosteal estimation1.63.86.0-2.42.3-2.42.41.9-1.8-1.0-0.2
Bone: periosteal perimeter1.22.43.8-2.01.9-1.81.71.7-1.6-0.2-0.5
Bone: post-yield work2.44.17.5-2.42.2-2.72.71.5-1.4-1.60.5
Progressive ratio test 1 active lever presses0.40.71.4-0.81.0-0.40.31.2-1.2-0.4-1.1
Progressive ratio test 1 breakpoint0.40.71.3-0.81.0-0.40.31.2-1.2-0.4-1.0
Progressive ratio test 1 inactive lever presses1.12.94.3-2.12.1-1.71.61.9-1.9-1.3-0.8
Progressive ratio test 2 active lever presses0.50.81.6-0.80.8-1.21.30.3-0.3-1.10.6
Progressive ratio test 2 breakpoint0.70.91.9-0.90.8-1.31.40.4-0.3-1.20.7
Progressive ratio test 2 inactive lever presses1.13.45.2-2.12.3-2.12.02.0-1.9-1.2-0.6
Incentive Sensitization - Responses0.71.84.3-1.31.3-2.02.10.7-0.6-1.01.0
Incentive Sensitization - Breakpoint0.61.43.5-1.11.0-1.81.90.4-0.3-0.91.1
Sum of active levers in priming session hrs 5-60.20.20.50.3-0.00.5-0.50.2-0.20.3-0.7
Progressive ratio0.10.42.2-0.10.10.4-0.50.3-0.41.5-0.7
Food seeking constrained by brief footshock3.84.716.40.10.51.9-2.32.1-2.01.9-4.0
Seeking ratio, punishment vs. effort0.40.81.7-0.60.8-0.20.11.3-1.2-0.9-1.3
Retroperitoneal fat weight3.013.523.14.1-4.42.8-2.4-4.84.81.13.4
Reaction time number correct0.20.85.00.4-0.30.6-0.6-0.30.22.2-0.3
Reaction time mean minus median0.00.00.10.00.1-0.10.10.1-0.0-0.2-0.0
Reaction time mean minus median AUC0.00.00.10.00.0-0.10.2-0.20.2-0.00.3
Reaction time num false alarms0.00.00.10.20.10.0-0.1-0.1-0.1-0.3-0.2
Reaction time num false alarms AUC0.20.30.80.7-0.30.8-0.9-0.2-0.00.0-0.8
Reaction time trials correct on left0.20.85.00.4-0.30.6-0.6-0.30.22.2-0.3
Reaction time trials on left0.20.84.90.4-0.30.6-0.6-0.20.22.2-0.3
Reaction time mean0.51.12.5-1.10.9-1.21.30.6-0.5-1.60.4
Reaction time mean AUC0.30.72.1-0.70.5-1.01.00.2-0.1-1.50.7
Median of all reaction times0.71.02.4-1.10.9-1.31.30.5-0.4-1.60.5
Reaction time omissions0.20.31.00.40.00.7-0.80.3-0.30.0-1.0
Reaction time false alarm rate0.20.20.80.4-0.10.5-0.5-0.0-0.1-0.9-0.7
Reaction time premature initiation rate0.30.42.9-0.20.1-0.40.4-0.00.1-1.70.4
Reaction time premature initiations0.00.10.30.1-0.2-0.10.1-0.30.4-0.60.5
Std. dev. reaction times0.20.71.1-0.80.8-1.01.10.5-0.4-1.10.3
Reaction time trials completed0.20.84.90.4-0.30.6-0.6-0.20.22.2-0.3
Reaction time trials AUC0.20.53.70.4-0.30.4-0.4-0.30.21.9-0.0
Run reversals in cocaine runway, females0.50.61.8-0.80.5-0.91.00.1-0.1-1.30.7
Run reversals in cocaine runway, males0.20.21.20.00.1-0.20.2-0.00.0-1.10.2
Latency to leave start box in cocaine runway0.30.50.7-0.80.8-0.70.60.7-0.7-0.8-0.2
Latency to leave start box in cocaine runway, F0.10.10.4-0.30.3-0.20.20.2-0.2-0.6-0.0
Latency to leave start box in cocaine runway, M1.21.21.5-1.11.2-1.21.21.1-1.0-1.2-0.3
Std. dev. time between licks in bursts0.91.63.80.5-0.21.4-1.60.5-0.61.9-2.0
Total sessions with >9 infusions0.81.01.6-0.91.3-0.80.71.2-1.2-1.1-0.8
Short access day 1 total inactive lever presses0.61.33.0-1.00.9-1.41.50.5-0.4-1.70.7
Short access day 10 total inactive lever presses0.00.31.0-0.40.4-0.60.60.4-0.4-1.00.0
Short access day 1 total infusions0.10.10.8-0.00.1-0.0-0.00.1-0.1-0.9-0.1
Short access day 10 total infusions0.00.00.20.1-0.10.2-0.2-0.00.0-0.5-0.1
Short access total infusions0.10.21.20.2-0.20.2-0.2-0.20.2-1.10.0
Short access day 1 locomotion0.50.93.9-0.70.8-0.90.90.4-0.3-2.00.3
Short access day 10 total locomotion0.31.23.0-0.71.1-0.20.01.6-1.6-0.6-1.7
Short access total locomotion0.60.92.7-0.20.70.3-0.41.2-1.1-0.8-1.6
One hour access (0.3 mA shock)3.13.65.6-2.12.3-2.42.31.9-1.8-1.2-0.2
Compulsive drug intake1.11.72.4-1.31.6-1.51.51.4-1.40.9-0.4
One hour access (shock baseline)0.30.82.2-0.80.5-1.01.10.0-0.0-1.50.8
Social response proportion1.01.22.8-1.10.8-1.41.50.4-0.3-1.70.8
Social responses2.43.14.1-2.01.9-2.01.91.7-1.6-1.9-0.2
Social time2.33.76.8-2.12.3-1.21.02.5-2.60.0-2.1
Soleus weight0.10.31.2-0.30.4-0.50.50.2-0.2-1.10.2
Bone: stiffness1.93.45.2-2.32.2-2.22.11.9-1.8-0.8-0.3
Tibialis anterior weight0.62.03.91.4-1.60.6-0.4-2.01.90.11.9
Time to tail flick, vehicle, before self-admin0.40.51.2-0.50.7-0.10.01.0-1.00.3-1.1
Time to tail flick, vehicle, after self-admin0.50.94.4-0.60.5-1.01.10.2-0.2-2.10.7
Time to tail flick, test, before self-admin0.70.82.70.7-0.11.1-1.20.6-0.6-0.3-1.6
Time to tail flick, test, after self-admin0.20.20.60.3-0.40.2-0.2-0.80.70.30.6
Delta time to tail flick, vehicle, before/after SA0.80.83.60.3-0.4-0.40.5-0.60.7-1.91.2
Delta time to tail flick, test, before/after SA0.40.51.4-0.70.3-0.80.9-0.50.40.41.2
Tibia length2.98.012.5-3.53.3-3.53.42.6-2.5-1.7-0.1
Ambulatory time before self-admin0.82.46.0-1.01.5-0.2-0.02.2-2.2-0.0-2.4
Ambulatory time after self-admin1.01.64.60.20.30.9-1.11.1-1.02.1-2.0
Bone: tissue strength0.50.52.0-0.30.50.3-0.40.9-1.0-0.1-1.4
Total heroin consumption0.10.10.50.3-0.20.4-0.4-0.0-0.10.7-0.4
Bone: trabecular number0.10.20.40.5-0.40.6-0.6-0.20.3-0.1-0.2
Bone: trabecular spacing0.00.00.1-0.1-0.0-0.20.2-0.20.1-0.10.4
Bone: trabecular thickness0.10.10.6-0.00.1-0.10.10.10.0-0.80.1
Bone: trabecular tissue density0.51.01.90.9-1.10.4-0.3-1.31.40.11.3
Water consumed over 24 hours0.51.01.7-1.11.2-0.70.51.3-1.3-0.5-1.0
Number of responses in last shaping day0.30.42.5-0.30.1-0.30.4-0.30.3-1.60.6