Hub : Genes

Dmrtb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Dmrtb1	0.06	0.04	3.4e-05	0.07	0.06	0.05	0.07	3.2e-06	6.0e-06	4.3e-05	4.4e-06
2	PL	gene expression	Dmrtb1	0.07	0.05	8.0e-03	0.01	0	0.01	0.01	1.5e-02	2.5e-01	2.4e-02	3.7e-02
3	NAcc	gene expression	Dmrtb1	0.03	0.02	5.9e-03	0	-0	0	-0	2.3e-01	6.1e-01	2.9e-01	6.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.4	0.7	1.3	-0.8	0.3	-1.1
Area under the delay curve	0.2	0.2	0.4	-0.1	-0.6	0.4
BMI with tail	0.7	2.4	6.9	2.6	0.4	0.4
BMI without tail	0.6	1.7	3.1	1.8	-0.7	-1.3
Body weight	0.4	1.7	4.9	2.2	0.5	-0.1
Weight adjusted by age	0.5	0.8	1.2	0.6	1.1	-0.8
Bone surface	0.1	0.1	0.3	-0.5	-0.0	-0.1
Bone volume	0.1	0.1	0.3	-0.0	0.5	-0.2
Breakpoint value in progressive ratio session	0.2	0.3	0.6	-0.3	0.8	0.3
Number of licking bursts	0.4	0.7	0.9	0.6	1.0	0.8
Context. condit. distance diff. score	0.8	1.0	1.3	-0.5	1.1	-1.2
Locomotion velocity, session 1	1.5	1.6	2.7	-1.7	0.9	1.2
Locomotion distance, session 1	0.1	0.1	0.3	-0.1	0.2	0.5
Locomotion velocity, session 2	1.4	1.6	2.9	-1.7	0.8	1.1
Locomotion distance, session 2	0.5	0.7	0.9	0.9	-0.9	0.6
Locomotion velocity, session 3	0.4	0.4	0.8	-0.9	0.5	0.4
Locomotion distance, session 3	0.3	0.3	0.8	0.3	-0.1	-0.9
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.0	0.6	0.8
Stereotopy head waving duration, day 3	0.3	0.3	0.5	-0.4	0.7	0.6
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	-0.2	-0.1
Locomotion distance, session 7	1.1	1.4	2.2	-0.1	-1.5	-1.4
Stereotopy head waving bouts, day 7	1.0	1.1	1.8	-1.3	0.8	0.9
Stereotopy head waving duration, day 7	1.2	1.4	1.9	-1.4	1.1	1.0
Locomotion velocity, session 8	0.7	0.9	1.7	-1.3	1.0	0.1
Locomotion distance, session 8	0.2	0.3	0.7	-0.0	0.3	-0.9
Degree of sensitization distance	0.2	0.2	0.5	0.1	-0.7	-0.3
Degree of sensitization stereotypy	0.6	0.7	1.1	-1.1	0.4	0.8
Conditioned locomotion	0.2	0.2	0.3	0.4	0.6	0.6
Cocaine response after cond. corrected	0.8	1.0	2.7	1.6	-0.5	-0.0
Cocaine response after cond. not corrected	1.0	1.2	3.6	1.9	0.2	-0.2
Cocaine response before conditioning	0.4	0.5	1.0	0.3	1.0	-0.6
Saline control response	0.7	0.9	2.1	-0.1	-1.5	-0.8
Bone: connectivity density	0.5	0.8	1.6	-1.3	-0.5	-0.9
Bone: cortical apparent density	1.1	1.4	2.5	-1.6	0.6	-1.2
Bone: cortical area	0.5	0.7	2.1	1.4	0.1	-0.3
Bone: cortical porosity	2.4	2.6	4.5	-0.1	1.8	2.1
Bone: cortical porosity	3.4	3.6	6.8	-0.5	2.0	2.6
Bone: cortical thickness	1.1	1.8	4.8	2.2	0.6	0.3
Bone: cortical thickness	1.5	1.8	2.7	1.7	1.6	0.4
Bone: cortical tissue density	1.1	1.5	2.6	-1.6	0.6	-1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.8	0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.8	0.9	0.9	-0.6
Condit. Reinf. active responses	0.7	0.8	1.6	1.3	0.2	0.9
Condit. Reinf. inactive responses	1.1	1.4	2.9	0.3	-1.0	1.7
Incentive salience index mean	0.8	1.0	2.6	1.6	0.7	0.2
Condit. Reinf. lever presses	0.8	1.2	3.0	1.7	0.2	0.7
Condit. Reinf. active minus inactive responses	1.8	2.3	5.3	0.5	-1.2	-2.3
Condit. Reinf. active-inactive response ratio	2.3	2.7	6.5	0.0	-1.3	-2.6
Condit. Reinf. active responses	1.3	1.9	4.8	0.7	-0.6	-2.2
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.9	0.6	-0.3
Condit. Reinf. lever presses	0.8	1.1	2.2	-0.5	-1.5	-0.9
Condit. Reinf. lever reinforcers received	1.0	1.3	3.2	0.6	-0.7	-1.8
Conditioned reinforcement - actives	0.5	0.9	1.7	1.3	-0.4	-0.9
Conditioned reinforcement - inactives	0.6	0.9	2.6	0.1	1.6	0.1
Conditioned locomotion	0.8	1.0	1.5	0.6	-1.1	-1.2
Patch foraging indifference point 0 sec	0.6	1.2	2.7	0.9	-1.7	-0.2
Patch foraging indifference point AUC	0.9	1.4	2.8	-0.7	-0.9	-1.7
Delay disc. indifference point, 0s delay	0.1	0.2	0.3	-0.6	-0.0	0.4
Delay disc. indifference point, 16s delay	0.8	0.9	1.2	1.1	-0.8	0.9
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	-0.3	0.8	-0.5
Delay disc. indifference point, 24s delay	0.5	0.6	1.1	-0.4	-1.1	0.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.1	-0.5	0.4
Delay disc. indifference point, 8s delay	0.5	0.6	1.5	-0.0	-1.2	0.6
Indifference point function ln k	0.3	0.6	0.9	1.0	-0.0	0.9
Indifference point function log k	0.3	0.6	0.9	1.0	-0.0	0.9
Patch foraging total patch changes 0 sec	0.6	1.2	2.8	0.8	-1.7	-0.3
Patch foraging total patch changes 12 sec	0.8	1.1	1.4	-1.2	-1.1	-0.7
Patch foraging total patch changes 18 sec	0.5	0.7	1.8	0.6	-0.0	-1.3
Patch foraging total patch changes 24 sec	0.4	0.6	1.5	1.2	-0.4	0.5
Patch foraging total patch changes 6 sec	0.5	0.8	2.1	0.3	-1.5	-0.4
Patch foraging time to switch 0 sec	1.0	2.0	2.3	-1.5	1.5	1.2
Patch foraging water rate 0 sec	0.7	1.5	4.2	2.0	-0.5	0.3
Patch foraging water rate 12 sec	0.9	1.9	5.2	2.3	-0.8	-0.1
Patch foraging water rate 18 sec	0.1	0.2	0.5	0.1	-0.4	0.7
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.4	0.5	-0.1
Patch foraging water rate 6 sec	1.5	2.2	3.3	1.6	-0.9	1.8
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	3.0	1.7	1.2	-0.7
Distance traveled before self-admin	0.6	0.8	2.2	0.4	-0.1	-1.5
Distance traveled after self-admin	1.9	2.3	3.5	1.1	-1.9	-1.4
Extensor digitorum longus weight	1.0	3.8	5.5	2.3	1.8	-1.6
Bone: elastic displacement	1.1	1.3	3.8	0.3	0.3	-1.9
Bone: elastic work	0.7	0.9	1.4	0.6	-0.9	-1.2
Bone: endosteal estimation	0.2	0.5	1.3	-0.5	0.1	-1.2
Bone: endosteal perimeter	0.2	0.4	0.7	-0.8	-0.8	0.0
Epididymis fat weight	0.1	0.3	0.3	-0.5	-0.5	0.5
Delta time in closed arm before/after self-admin	4.2	3.9	11.8	-0.0	0.1	-3.4
Delta time in open arm before/after self-admin	2.0	1.9	3.2	0.2	-1.6	1.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.1	0.4	0.4
Delay discount exponential model param	0.2	0.2	0.5	0.1	0.7	-0.4
Extinction: sum of active levers before priming	0.5	0.6	1.7	0.3	1.3	-0.1
Active lever presses in extinction session 6	0.9	0.9	1.5	1.2	0.9	0.6
Bone: final force	0.0	0.0	0.0	-0.1	-0.1	-0.2
Bone: final moment	0.0	0.0	0.0	0.1	-0.2	-0.2
Food consumed during 24 hour testing period	1.0	1.3	3.6	0.5	-1.9	0.3
Glucose	0.0	0.1	0.1	0.3	-0.1	-0.2
Heart weight	1.6	2.4	4.3	1.7	2.1	0.2
Delay discount hyperbolic model param	0.1	0.1	0.3	0.2	0.5	-0.3
Intermittent access intake day 1-15 change	0.3	0.6	0.8	0.9	-0.7	-0.7
Intermittent access intake escalation	0.3	0.5	0.9	1.0	-0.7	-0.4
Intermittent access intake escalation 2	0.3	0.4	0.9	0.4	-0.9	-0.2
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.6	1.3	0.9	-0.6
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.5	0.7	0.3	0.3
Intermitt. access escalation Index	0.1	0.1	0.2	0.3	-0.5	0.3
Intermittent access day 1 total infusions	0.7	1.2	3.0	-0.4	1.7	0.6
Intermittent access day 15 total infusions	0.2	0.3	0.5	0.5	0.7	0.2
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.1	0.5	-0.6
Intermittent access total infusions	0.4	0.5	1.4	-0.1	1.2	-0.2
Intermittent access day 1 locomotion	0.9	1.2	2.8	-0.2	1.7	0.8
Intermittent access day 15 total locomotion	0.0	0.0	0.0	0.1	-0.0	0.0
Intermittent access total locomotion	0.1	0.2	0.5	-0.0	0.7	0.1
Intermittent access standard deviation	0.8	1.8	3.2	1.8	1.4	0.3
Left kidney weight	2.2	10.1	28.9	5.4	0.5	-1.1
Right kidney weight	1.4	6.3	18.6	4.3	0.3	-0.5
Cocaine induced anxiety	0.2	0.3	0.7	0.8	-0.5	-0.0
Post-drug Anxiety	0.5	0.5	1.1	1.0	0.5	0.6
Baseline Anxiety	2.9	3.3	6.0	0.4	2.5	2.0
Tail length	0.2	0.6	1.8	-0.0	-0.1	-1.3
Length with tail	0.1	0.4	0.7	0.8	-0.0	-0.8
Length without tail	0.5	1.6	4.6	2.1	-0.3	0.2
Times rat made contact with spout	0.8	0.9	2.0	0.5	-1.4	-0.7
Lifetime Intake	0.4	0.5	1.5	-0.2	1.2	-0.1
Liver weight, left	0.1	0.2	0.2	-0.5	-0.4	-0.2
Liver weight, right	0.3	0.5	0.9	-0.6	-0.5	-0.9
Locomotor activity	0.5	0.8	1.3	0.0	-1.2	-1.1
Locomotor testing distance	1.1	1.9	3.2	0.4	-1.5	-1.8
Locomotor testing rearing	1.2	2.4	6.1	0.2	-1.1	-2.5
Locomotion in novel chamber	1.9	2.5	4.4	2.1	-0.2	1.7
Locomotion in novel chamber post-restriction	0.5	0.8	1.6	0.4	1.3	0.7
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.1	-0.5	0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.7	-0.1	0.1
Time >=10cm from walls, locomotor time 1	1.4	1.5	3.8	-0.9	0.1	-1.9
Bouts of movement, locomotor time 1	0.3	0.4	0.9	-0.9	-0.4	0.3
Total resting periods, locomotor time 1	0.4	0.5	0.7	-0.8	-0.3	0.8
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.3	-0.2	0.7
Distance moved, locomotor task time 1	0.3	0.5	1.0	-0.3	0.5	-1.0
Vertical activity count, locomotor time 1	0.1	0.3	0.5	0.5	-0.2	-0.7
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.5	0.2	0.0	-1.2
Bouts of movement, locomotor time 2	0.5	0.8	1.2	-0.5	0.9	-1.1
Total resting periods, locomotor time 2	0.4	0.6	1.0	-0.5	0.7	-1.0
Rest time, locomotor task time 2	0.4	0.6	1.3	-0.3	-1.1	0.5
Distance moved, locomotor task time 2	0.6	0.8	1.4	0.8	0.5	-1.2
Vertical activity count, locomotor time 2	0.4	0.6	1.5	1.2	0.0	-0.6
Light reinforcement 1	0.1	0.4	0.4	0.6	0.5	0.7
Light reinforcement 2	0.5	0.8	2.2	1.5	0.2	0.3
Bone: marrow area	0.2	0.5	1.4	-0.4	0.1	-1.2
Bone: maximum diameter	0.1	0.2	0.3	0.5	0.5	0.3
Bone: maximum force	0.1	0.2	0.3	0.0	-0.6	-0.4
Bone: maximum moment	0.1	0.2	0.2	0.2	-0.5	-0.5
Mean time between licks in bursts	0.4	1.1	2.8	-1.7	-0.5	0.2
Mean num. licks in bursts	0.8	1.2	2.4	0.3	-1.5	-1.1
Cd content in liver	2.0	2.2	5.4	-0.9	0.6	-2.3
Co content in liver	1.2	1.4	4.1	-0.2	-0.1	-2.0
Cu content in liver	3.2	3.8	6.1	-0.7	-2.1	-2.5
Fe content in liver	0.5	0.6	0.9	0.9	-0.4	-0.9
K content in liver	1.1	1.0	2.4	-0.7	-1.5	-0.3
Mg content in liver	1.4	1.5	3.6	0.6	-1.9	0.6
Mn content in liver	0.4	0.5	1.1	-0.5	1.1	-0.1
Na content in liver	0.3	0.3	0.7	-0.8	-0.2	-0.5
Rb content in liver	0.1	0.1	0.2	-0.2	-0.4	-0.2
Se content in liver	0.6	0.8	1.8	-0.4	-0.6	-1.3
Sr content in liver	0.8	0.7	1.5	0.0	1.2	-0.7
Zn content in liver	0.5	0.5	1.1	-1.1	-0.6	-0.2
Bone: minimum diameter	0.7	1.3	2.4	0.5	-1.5	-1.2
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.4	-0.3	-0.9
Time in novel zone, hab. session 1	0.4	0.4	1.1	-0.5	-0.0	-1.0
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.1	0.7	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.7	0.8	0.6	0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.7	0.6	0.4	0.9
Time in familiar zone, hab. session 2	1.7	1.8	3.0	-0.8	-1.3	-1.7
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	0.6	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.1	-0.5	-0.3
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.9	-0.5	0.4
Locomotion velocity, hab. session 2	0.4	0.5	1.0	1.0	-0.3	0.7
Novel to familiar place preference ratio	1.3	1.4	3.6	0.8	-1.9	0.3
Novelty place preference	0.9	1.0	2.8	0.4	-1.7	0.2
Time in novel zone, NPP test	0.6	0.6	1.8	0.3	-1.3	-0.1
Total zone transitions, NPP test	0.5	0.7	1.6	1.3	0.6	-0.3
Total locomotion distance, NPP test	0.5	0.7	2.0	1.4	0.3	0.0
Locomotion velocity, NPP test	0.8	1.1	3.0	1.7	0.3	0.3
Intraocular pressure	0.4	0.6	1.4	0.6	-0.2	1.2
Delta distance traveled before/after self-admin	1.1	1.1	1.6	1.3	-1.2	0.6
Delta ambulatory time before/after self-admin	0.5	0.7	1.1	1.1	-0.9	0.3
Parametrial fat weight	0.7	1.6	3.6	0.0	-1.9	1.1
Pavlov. Cond. lever latency	0.9	1.2	2.8	-1.7	-0.4	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	-0.6	-0.4	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.1	0.4	0.1
Pavlov. Cond. index score	0.1	0.2	0.5	0.7	0.1	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.6	0.8	0.1	0.1
Pavlov. Cond. lever contacts	0.6	0.8	1.9	1.4	0.2	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.6	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	1.3	1.5	1.9	0.9	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.8	-0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.1	0.3	0.2	-0.3
Pavlov. Cond. lever latency	1.2	1.6	4.9	-0.0	2.2	0.1
Pavlov. Cond. magazine entry latency	2.7	3.3	5.7	-1.2	-2.4	-1.7
Pavlov. Cond. change in total contacts	1.0	1.6	4.6	-0.4	-2.2	-0.1
Pavlov. Cond. index score	2.3	3.1	7.9	-0.8	-2.8	-1.0
Pavlov. Cond. latency score	2.4	3.2	7.9	-0.7	-2.8	-1.1
Pavlov. Cond. lever contacts	1.0	1.3	3.7	0.0	-1.9	-0.5
Pavlov. Cond. magazine entry number	2.6	3.2	4.7	1.7	2.2	1.3
Pavlov. Cond. intertrial magazine entries	0.6	1.0	1.8	0.0	1.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.7	9.3	-0.9	-3.0	-1.0
Pavlov. Cond. response bias	1.2	1.6	3.9	-0.6	-2.0	-0.7
Time in closed arm before self-admin	0.8	1.0	2.1	-0.7	-0.7	1.4
Time in closed arm after self-admin	0.2	0.2	0.6	-0.3	-0.1	-0.8
Time in open arm before self-admin	0.9	1.0	2.9	0.1	0.1	-1.7
Time in open arm after self-admin	0.8	0.9	1.9	0.7	-1.4	0.5
Bone: periosteal estimation	0.2	0.4	0.6	0.8	0.3	-0.8
Bone: periosteal perimeter	0.0	0.1	0.1	0.2	-0.3	-0.2
Bone: post-yield work	0.1	0.1	0.2	-0.3	0.1	0.4
Progressive ratio test 1 active lever presses	1.0	1.2	2.5	0.7	1.6	0.8
Progressive ratio test 1 breakpoint	0.9	1.2	2.3	0.7	1.5	0.8
Progressive ratio test 1 inactive lever presses	0.9	1.3	3.5	0.5	1.9	-0.0
Progressive ratio test 2 active lever presses	0.3	0.4	0.9	0.5	0.9	0.3
Progressive ratio test 2 breakpoint	0.4	0.4	0.9	0.5	0.9	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	-0.0	0.6	0.3
Incentive Sensitization - Responses	0.2	0.3	0.9	-0.1	0.0	0.9
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	0.0	0.1	0.8
Sum of active levers in priming session hrs 5-6	1.0	0.9	2.2	0.3	1.5	-0.7
Progressive ratio	0.4	0.7	1.5	0.5	0.4	1.2
Food seeking constrained by brief footshock	2.0	2.4	4.6	-2.1	-0.1	-1.6
Seeking ratio, punishment vs. effort	2.7	3.9	7.5	-2.1	-0.2	-2.7
Retroperitoneal fat weight	0.1	0.5	0.8	-0.6	-0.9	0.6
Reaction time number correct	0.1	0.2	0.5	0.1	0.7	-0.1
Reaction time mean minus median	0.2	0.5	1.0	-0.6	-1.0	0.1
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.6	-0.5	-0.2
Reaction time num false alarms	0.7	1.1	1.1	1.0	-1.0	1.0
Reaction time num false alarms AUC	0.9	1.3	2.1	1.4	-0.9	1.1
Reaction time trials correct on left	0.1	0.2	0.5	0.1	0.7	-0.1
Reaction time trials on left	0.1	0.1	0.4	0.1	0.6	-0.1
Reaction time mean	0.8	1.3	1.7	-0.9	-1.3	1.2
Reaction time mean AUC	0.5	0.8	1.1	-1.0	-1.0	0.6
Median of all reaction times	0.9	1.3	2.2	-0.9	-1.0	1.5
Reaction time omissions	0.4	0.6	1.3	-0.1	-1.1	0.8
Reaction time false alarm rate	1.1	1.4	1.9	1.4	-1.2	1.0
Reaction time premature initiation rate	1.1	1.5	4.1	-0.6	-2.0	-0.0
Reaction time premature initiations	0.5	0.9	2.3	-0.6	-1.5	-0.2
Std. dev. reaction times	0.3	0.6	1.6	-0.5	-1.3	0.1
Reaction time trials completed	0.1	0.1	0.4	0.1	0.6	-0.1
Reaction time trials AUC	0.1	0.1	0.2	0.2	0.5	-0.0
Run reversals in cocaine runway, females	1.2	1.2	2.8	-0.5	-0.7	1.7
Run reversals in cocaine runway, males	1.0	1.0	2.1	1.4	0.1	-1.0
Latency to leave start box in cocaine runway	1.7	1.9	3.6	1.0	1.9	1.0
Latency to leave start box in cocaine runway, F	3.0	3.4	6.9	1.4	2.6	1.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	-0.5	-0.1
Std. dev. time between licks in bursts	1.1	1.5	3.2	-1.8	0.0	1.2
Total sessions with >9 infusions	0.7	0.9	2.4	-0.3	1.6	0.2
Short access day 1 total inactive lever presses	0.9	1.2	2.3	1.5	1.2	0.1
Short access day 10 total inactive lever presses	0.2	0.6	1.1	0.5	-0.6	-1.0
Short access day 1 total infusions	0.9	1.2	3.3	0.1	1.8	0.4
Short access day 10 total infusions	0.8	1.1	3.1	0.2	1.8	0.1
Short access total infusions	0.6	0.8	2.2	-0.3	1.5	0.3
Short access day 1 locomotion	0.4	0.5	0.8	0.8	0.1	-0.9
Short access day 10 total locomotion	0.4	0.7	1.5	0.8	0.2	1.2
Short access total locomotion	0.2	0.2	0.4	-0.3	0.6	-0.4
One hour access (0.3 mA shock)	0.4	0.5	0.8	-0.6	0.6	-0.9
Compulsive drug intake	0.2	0.3	0.5	-0.7	0.1	0.5
One hour access (shock baseline)	0.3	0.5	0.8	0.9	0.5	-0.7
Social response proportion	0.2	0.2	0.3	-0.6	-0.5	-0.1
Social responses	0.7	0.9	1.9	-1.4	-0.6	-0.6
Social time	0.1	0.1	0.2	0.4	-0.3	-0.3
Soleus weight	1.3	3.7	9.9	3.1	-0.4	-1.1
Bone: stiffness	0.0	0.1	0.2	-0.1	0.5	0.1
Tibialis anterior weight	2.2	7.4	15.7	4.0	2.5	-0.3
Time to tail flick, vehicle, before self-admin	2.0	2.1	2.5	1.6	1.4	1.4
Time to tail flick, vehicle, after self-admin	2.0	2.6	3.3	1.2	1.7	1.8
Time to tail flick, test, before self-admin	1.3	1.4	3.8	1.9	-0.2	0.6
Time to tail flick, test, after self-admin	1.1	1.1	1.8	1.4	1.0	0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.3	0.6	0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	-0.4	0.9	0.6
Tibia length	0.2	0.7	1.2	0.8	0.4	1.1
Ambulatory time before self-admin	0.6	0.9	2.6	0.2	0.1	-1.6
Ambulatory time after self-admin	0.8	1.0	1.5	0.9	-0.8	-1.2
Bone: tissue strength	1.4	1.4	2.0	-1.0	-1.4	-1.1
Total heroin consumption	0.9	1.1	2.4	-0.7	1.5	0.6
Bone: trabecular number	0.8	1.4	2.8	-0.9	-0.7	-1.7
Bone: trabecular spacing	1.6	2.2	2.4	1.5	1.6	1.4
Bone: trabecular thickness	0.8	1.0	1.2	-1.0	-1.1	-1.0
Bone: trabecular tissue density	0.2	0.3	0.4	-0.6	0.5	-0.5
Water consumed over 24 hours	1.7	2.3	4.5	1.0	-1.2	-2.1
Number of responses in last shaping day	1.1	1.2	3.0	1.7	-0.5	-0.6