Hub : Genes

Dmkn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Dmkn 0.03 0.02 8.4e-07 0.03 0.04 0.02 0.03 1.7e-05 3.2e-06 2.4e-04 3.6e-05
2 BLA gene expression Dmkn 0.18 0.09 5.5e-08 0.16 0.13 0.13 0.14 5.0e-09 1.8e-07 3.0e-07 5.5e-08
3 PL gene expression Dmkn 0.04 0.03 4.9e-05 0.03 0.03 0.03 0.03 6.2e-04 1.4e-04 3.6e-04 3.6e-04
4 Brain gene expression Dmkn 0.04 0.03 1.9e-05 0.04 0.06 0.03 0.05 9.4e-05 4.0e-06 8.5e-04 1.7e-05
5 IC gene expression Dmkn 0.19 0.11 1.7e-06 0.13 -0 0.11 -0 4.4e-06 5.3e-01 2.2e-05 5.5e-01
6 Brain intron excision ratio chr1_95155849_95157235 0.08 0.06 2.6e-04 0.03 0.03 0.03 0.02 6.5e-04 9.5e-04 8.5e-04 5.2e-03
7 NAcc intron excision ratio chr1_95155849_95157235 0.04 0.03 1.0e-05 0.04 0.03 0.04 0.04 2.6e-07 9.8e-06 1.2e-06 1.9e-06
8 Adipose gene expression Dmkn 0.68 0.1 0.0e+00 0.39 0.4 0.41 0.4 1.5e-46 5.7e-48 7.9e-49 5.5e-47

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.72.2-1.4-1.3-1.4-1.5-1.41.21.20.8
Area under the delay curve0.30.31.6-0.3-0.3-0.2-0.2-0.60.2-0.5-1.2
BMI with tail0.10.41.60.40.40.50.50.4-0.5-0.6-1.3
BMI without tail0.10.40.7-0.7-0.7-0.6-0.6-0.70.60.2-0.8
Body weight3.013.017.4-4.2-4.0-4.1-4.1-3.83.72.80.8
Weight adjusted by age0.10.20.3-0.5-0.6-0.5-0.4-0.60.20.4-0.0
Bone surface1.32.43.6-1.7-1.9-1.7-1.4-1.91.81.00.1
Bone volume1.73.04.2-1.9-2.0-2.0-1.7-2.02.01.20.3
Breakpoint value in progressive ratio session0.50.61.0-0.8-0.8-0.8-0.8-1.00.80.3-0.7
Number of licking bursts2.54.05.72.31.82.22.41.7-1.8-2.3-1.5
Context. condit. distance diff. score0.30.31.70.2-0.20.10.40.00.1-0.9-1.3
Locomotion velocity, session 10.20.20.40.20.50.20.10.6-0.5-0.00.6
Locomotion distance, session 10.60.81.2-0.8-0.9-0.9-0.5-0.91.0-0.8-1.1
Locomotion velocity, session 20.91.01.71.01.11.01.01.3-1.1-0.80.1
Locomotion distance, session 21.62.23.21.41.31.31.71.5-1.3-1.8-1.5
Locomotion velocity, session 30.30.30.70.50.40.40.70.8-0.3-0.60.0
Locomotion distance, session 31.61.83.0-1.2-1.6-1.3-0.7-1.31.6-0.8-1.7
Stereotopy head waving bouts, day 30.70.82.90.51.00.60.10.8-0.90.91.7
Stereotopy head waving duration, day 31.11.42.60.91.51.10.51.1-1.40.81.6
Locomotion velocity, session 70.30.30.7-0.5-0.7-0.6-0.3-0.40.7-0.4-0.8
Locomotion distance, session 70.30.40.7-0.7-0.8-0.8-0.5-0.30.80.40.4
Stereotopy head waving bouts, day 72.22.43.61.81.41.71.91.4-1.4-1.8-0.9
Stereotopy head waving duration, day 72.22.63.41.81.71.81.71.6-1.7-1.4-0.8
Locomotion velocity, session 84.04.85.92.32.02.22.42.4-2.1-2.4-1.6
Locomotion distance, session 81.31.93.81.20.61.11.71.1-0.7-2.0-1.9
Degree of sensitization distance0.50.52.90.20.30.2-0.00.4-0.31.01.7
Degree of sensitization stereotypy2.32.44.71.71.11.61.91.1-1.2-2.2-1.4
Conditioned locomotion0.91.11.31.01.01.11.00.8-1.0-1.1-1.1
Cocaine response after cond. corrected0.20.20.8-0.10.30.0-0.40.4-0.30.40.9
Cocaine response after cond. not corrected0.50.53.0-0.20.0-0.1-0.50.3-0.10.91.7
Cocaine response before conditioning1.21.42.4-1.0-1.6-1.2-0.8-1.21.40.91.2
Saline control response0.10.10.40.20.20.20.10.4-0.30.10.6
Bone: connectivity density0.20.30.6-0.6-0.6-0.6-0.6-0.80.70.30.1
Bone: cortical apparent density0.81.11.61.11.11.11.11.3-1.2-0.9-0.8
Bone: cortical area1.72.73.3-1.8-1.7-1.8-1.8-1.31.61.81.1
Bone: cortical porosity2.52.75.71.81.31.62.01.0-1.2-2.4-1.5
Bone: cortical porosity3.23.56.62.01.51.92.21.3-1.4-2.6-1.7
Bone: cortical thickness0.91.42.4-1.3-1.1-1.3-1.3-0.81.01.61.0
Bone: cortical thickness0.30.40.70.50.80.50.40.8-0.80.40.3
Bone: cortical tissue density1.11.41.91.21.21.21.21.4-1.3-1.1-1.0
Condit. Reinf. active minus inactive responses0.30.30.60.50.70.50.40.4-0.6-0.8-0.4
Condit. Reinf. active-inactive response ratio0.20.30.70.20.80.4-0.10.3-0.80.30.6
Condit. Reinf. active responses2.32.94.41.61.71.71.61.7-1.7-2.1-1.5
Condit. Reinf. inactive responses3.13.87.31.81.51.82.01.8-1.5-2.7-2.3
Incentive salience index mean0.40.51.30.60.70.60.60.5-0.7-1.1-0.7
Condit. Reinf. lever presses0.30.41.60.40.40.40.40.3-0.3-1.3-1.0
Condit. Reinf. active minus inactive responses0.50.71.0-1.0-0.9-1.0-0.9-0.70.90.40.4
Condit. Reinf. active-inactive response ratio0.10.10.40.20.20.20.20.6-0.2-0.3-0.0
Condit. Reinf. active responses1.72.33.4-1.7-1.9-1.8-1.5-1.71.80.60.4
Condit. Reinf. inactive responses1.72.24.1-1.5-1.9-1.6-1.2-2.01.90.1-0.3
Condit. Reinf. lever presses5.17.19.1-2.9-3.0-3.0-2.8-3.02.91.91.1
Condit. Reinf. lever reinforcers received1.82.64.1-1.8-2.0-1.9-1.5-1.82.00.40.1
Conditioned reinforcement - actives0.40.60.80.90.80.80.90.8-0.8-0.50.7
Conditioned reinforcement - inactives0.81.25.00.50.10.50.80.1-0.1-1.9-2.2
Conditioned locomotion2.12.73.41.81.81.81.81.8-1.8-1.6-0.4
Patch foraging indifference point 0 sec0.00.00.30.1-0.00.10.2-0.1-0.0-0.6-0.0
Patch foraging indifference point AUC0.50.71.30.90.90.90.81.1-0.9-0.6-0.3
Delay disc. indifference point, 0s delay1.21.37.1-0.3-0.5-0.2-0.0-0.80.4-1.5-2.7
Delay disc. indifference point, 16s delay0.30.42.1-0.3-0.3-0.2-0.2-0.40.2-0.7-1.4
Delay disc. indifference point, 2s delay0.91.01.8-1.0-1.1-1.0-0.8-1.31.0-0.3-1.1
Delay disc. indifference point, 24s delay1.01.11.5-1.2-1.2-1.1-1.1-1.11.2-0.0-0.9
Delay disc. indifference point, 4s delay0.30.40.90.50.30.50.60.0-0.4-0.9-0.9
Delay disc. indifference point, 8s delay0.00.10.1-0.2-0.3-0.2-0.1-0.40.20.1-0.2
Indifference point function ln k0.20.30.5-0.6-0.6-0.7-0.5-0.60.60.60.3
Indifference point function log k0.20.30.5-0.6-0.6-0.7-0.5-0.60.60.60.3
Patch foraging total patch changes 0 sec0.00.00.2-0.0-0.2-0.00.0-0.20.1-0.5-0.0
Patch foraging total patch changes 12 sec0.10.20.30.40.50.40.20.4-0.4-0.10.5
Patch foraging total patch changes 18 sec0.20.31.00.50.20.50.70.2-0.2-1.0-0.5
Patch foraging total patch changes 24 sec0.40.71.3-0.7-1.2-0.7-0.5-1.01.1-0.5-0.7
Patch foraging total patch changes 6 sec0.00.10.20.20.20.20.10.4-0.3-0.10.4
Patch foraging time to switch 0 sec0.40.81.40.91.11.00.61.0-1.2-0.10.6
Patch foraging water rate 0 sec0.40.81.20.90.90.91.01.1-0.9-0.8-0.5
Patch foraging water rate 12 sec0.30.71.5-0.6-1.2-0.8-0.2-1.21.2-0.20.2
Patch foraging water rate 18 sec0.10.10.20.40.40.30.50.4-0.4-0.20.3
Patch foraging water rate 24 sec0.71.03.90.5-0.10.31.10.00.1-1.6-2.0
Patch foraging water rate 6 sec0.71.11.8-0.8-1.4-1.0-0.4-1.31.3-0.8-1.0
Seeking ratio, delayed vs. immediate footshock1.11.32.3-0.9-1.4-1.0-0.6-1.31.4-0.7-1.5
Distance traveled before self-admin0.00.00.0-0.0-0.2-0.10.0-0.10.20.10.0
Distance traveled after self-admin1.51.92.7-1.4-1.6-1.5-1.3-1.41.60.90.9
Extensor digitorum longus weight0.20.84.2-0.40.3-0.2-0.90.6-0.62.10.5
Bone: elastic displacement0.20.21.0-0.1-0.0-0.1-0.3-0.10.00.71.0
Bone: elastic work1.72.33.0-1.7-1.5-1.6-1.7-1.71.51.30.8
Bone: endosteal estimation1.22.63.3-1.7-1.8-1.8-1.5-1.71.81.41.0
Bone: endosteal perimeter0.71.52.5-1.4-1.6-1.4-1.1-1.31.50.70.4
Epididymis fat weight0.10.30.7-0.6-0.5-0.6-0.5-0.50.30.8-0.0
Delta time in closed arm before/after self-admin1.11.01.4-1.2-1.2-1.1-1.1-1.11.10.6-0.0
Delta time in open arm before/after self-admin0.40.40.60.80.70.70.70.5-0.7-0.30.4
Diff in mean of infusions in LGA sessions0.91.11.41.11.11.21.11.0-1.2-0.8-1.1
Delay discount exponential model param0.20.20.90.40.40.30.30.6-0.30.30.9
Extinction: sum of active levers before priming4.85.37.0-2.5-2.1-2.4-2.6-2.32.12.61.6
Active lever presses in extinction session 63.33.37.6-1.6-1.0-1.6-2.0-1.11.02.52.8
Bone: final force1.62.53.4-1.9-1.8-1.8-1.8-1.61.71.10.1
Bone: final moment2.23.54.8-2.2-2.1-2.2-2.1-1.92.11.40.3
Food consumed during 24 hour testing period0.30.41.1-0.3-0.9-0.4-0.0-1.00.6-0.4-0.7
Glucose0.20.31.50.20.20.20.10.4-0.40.31.2
Heart weight0.10.10.50.1-0.10.00.3-0.1-0.0-0.7-0.7
Delay discount hyperbolic model param0.20.21.00.30.30.20.20.6-0.20.31.0
Intermittent access intake day 1-15 change1.53.24.0-2.0-2.0-1.9-2.0-2.02.01.50.2
Intermittent access intake escalation1.53.03.7-1.9-1.8-1.9-1.9-1.81.81.60.6
Intermittent access intake escalation 21.51.72.2-1.4-1.3-1.4-1.5-1.21.31.51.1
Intermitt. access day 1 inactive lever presses0.62.33.0-1.7-1.7-1.6-1.5-1.71.70.1-1.3
Intermitt. access day 15 inactive lever presses0.51.04.6-0.4-0.6-0.4-0.2-0.60.6-1.3-2.1
Intermitt. access escalation Index0.40.61.60.70.20.61.00.2-0.2-1.2-1.3
Intermittent access day 1 total infusions2.54.08.72.21.32.02.61.3-1.3-3.0-1.6
Intermittent access day 15 total infusions0.30.41.40.3-0.30.10.5-0.30.3-1.2-1.0
Intermittent access terminal intake (last 3 days)0.81.12.91.00.30.81.30.3-0.3-1.7-1.4
Intermittent access total infusions1.21.44.21.20.41.01.60.5-0.4-2.0-1.3
Intermittent access day 1 locomotion3.13.910.41.91.11.72.31.1-1.1-3.2-2.4
Intermittent access day 15 total locomotion0.40.72.60.5-0.10.40.9-0.10.1-1.6-1.3
Intermittent access total locomotion2.02.35.21.61.01.51.81.1-1.0-2.3-1.5
Intermittent access standard deviation1.42.94.7-1.8-2.2-1.8-1.5-2.22.20.4-0.7
Left kidney weight2.511.715.3-3.9-3.7-3.9-3.9-3.53.52.81.4
Right kidney weight3.314.919.1-4.3-4.0-4.3-4.4-3.93.73.82.1
Cocaine induced anxiety0.00.10.3-0.30.0-0.2-0.50.0-0.00.30.0
Post-drug Anxiety0.30.31.40.20.50.40.00.6-0.5-0.4-1.2
Baseline Anxiety0.60.62.70.50.20.50.60.3-0.2-1.2-1.7
Tail length4.417.121.9-4.6-4.6-4.7-4.4-4.54.43.31.5
Length with tail6.025.933.2-5.7-5.7-5.8-5.5-5.65.53.91.9
Length without tail3.110.013.5-3.6-3.5-3.7-3.6-3.33.42.31.0
Times rat made contact with spout0.20.21.10.10.10.0-0.00.1-0.30.71.0
Lifetime Intake1.01.23.41.20.51.01.50.6-0.5-1.8-0.7
Liver weight, left0.40.60.90.80.80.80.81.0-0.8-0.7-0.0
Liver weight, right0.30.51.00.50.80.50.31.0-0.90.30.7
Locomotor activity0.71.14.50.61.00.50.30.6-1.10.92.1
Locomotor testing distance0.50.92.90.81.00.70.70.6-0.90.41.7
Locomotor testing rearing0.71.42.11.51.41.31.51.2-1.2-0.50.8
Locomotion in novel chamber0.40.50.90.61.00.70.41.0-0.90.50.5
Locomotion in novel chamber post-restriction0.10.10.40.40.60.50.30.5-0.30.10.1
Fecal boli incidents, locomotor time 12.43.55.72.02.42.11.72.3-2.3-0.50.0
Change in fecal boli incidents, locomotor task0.60.62.0-0.50.1-0.3-0.80.2-0.01.21.4
Time >=10cm from walls, locomotor time 10.00.00.10.10.30.20.10.2-0.3-0.2-0.1
Bouts of movement, locomotor time 10.50.62.1-0.3-0.7-0.40.0-0.80.7-0.8-1.4
Total resting periods, locomotor time 10.30.31.3-0.2-0.5-0.30.0-0.60.5-0.5-1.1
Rest time, locomotor task time 11.82.23.71.51.91.71.21.9-1.9-0.4-0.6
Distance moved, locomotor task time 10.10.20.7-0.3-0.8-0.4-0.1-0.50.60.20.2
Vertical activity count, locomotor time 10.71.73.4-1.3-1.8-1.4-1.0-1.61.60.40.1
Time >=10cm from walls, locomotor time 21.42.12.81.61.71.61.51.6-1.6-1.1-0.6
Bouts of movement, locomotor time 20.00.00.10.2-0.10.00.4-0.10.1-0.40.1
Total resting periods, locomotor time 20.10.10.30.40.20.30.60.1-0.2-0.40.3
Rest time, locomotor task time 20.60.71.20.91.11.00.71.0-1.1-0.20.2
Distance moved, locomotor task time 20.10.10.20.1-0.4-0.00.3-0.10.2-0.1-0.4
Vertical activity count, locomotor time 20.50.71.5-0.9-1.2-0.9-0.6-0.91.10.2-0.6
Light reinforcement 10.10.30.60.60.30.50.80.3-0.4-0.7-0.3
Light reinforcement 21.72.64.21.62.01.71.51.9-2.1-0.8-0.8
Bone: marrow area1.22.73.3-1.7-1.8-1.8-1.6-1.71.81.51.2
Bone: maximum diameter1.12.12.8-1.7-1.6-1.7-1.6-1.41.61.20.6
Bone: maximum force2.54.45.8-2.4-2.4-2.4-2.3-2.32.31.40.3
Bone: maximum moment3.15.47.1-2.7-2.7-2.7-2.5-2.42.61.60.4
Mean time between licks in bursts0.10.20.70.20.30.20.4-0.0-0.0-0.5-0.8
Mean num. licks in bursts2.13.35.7-1.9-1.5-1.9-2.1-1.41.32.41.8
Cd content in liver0.00.00.10.20.20.20.10.2-0.20.20.2
Co content in liver0.30.40.80.50.80.60.20.9-0.80.30.5
Cu content in liver1.21.51.9-1.4-1.3-1.4-1.4-1.41.31.00.2
Fe content in liver0.30.40.70.70.90.70.60.6-0.9-0.10.2
K content in liver0.00.00.10.10.20.10.00.1-0.20.10.3
Mg content in liver0.60.61.20.61.10.60.31.0-1.10.41.0
Mn content in liver0.91.02.30.71.10.80.41.2-1.10.51.5
Na content in liver0.50.50.9-0.7-0.9-0.7-0.5-0.80.90.20.4
Rb content in liver0.30.41.50.30.50.50.20.3-0.5-0.7-1.2
Se content in liver3.94.68.02.12.82.21.62.8-2.8-0.30.7
Sr content in liver0.40.41.10.60.60.60.50.5-0.6-0.21.1
Zn content in liver1.41.63.21.21.81.30.81.5-1.80.10.3
Bone: minimum diameter1.83.35.6-2.0-2.4-2.0-1.6-2.02.40.70.0
Time in familiar zone, hab. session 11.81.73.1-1.5-0.9-1.4-1.7-0.40.91.81.3
Time in novel zone, hab. session 12.82.85.02.01.61.92.21.0-1.5-1.7-1.0
Total zone transitions, hab. session 10.30.41.50.2-0.10.10.50.30.1-1.2-1.0
Total locomotion distance, hab. session 10.30.41.1-0.3-0.7-0.5-0.0-1.10.9-0.80.3
Locomotion velocity, hab. session 10.20.30.7-0.3-0.5-0.4-0.0-0.80.6-0.60.6
Time in familiar zone, hab. session 21.51.62.9-1.2-0.9-1.1-1.5-1.20.81.71.5
Time in novel zone, hab. session 20.80.81.21.00.80.91.10.9-0.8-0.9-0.6
Total zone transitions, hab. session 23.54.45.92.32.12.12.42.1-2.1-2.3-1.3
Total locomotion distance, hab. session 20.91.22.81.20.81.01.50.4-0.7-1.7-0.8
Locomotion velocity, hab. session 20.81.02.21.20.91.01.40.5-0.7-1.5-0.6
Novel to familiar place preference ratio0.10.10.2-0.2-0.4-0.2-0.1-0.40.3-0.2-0.4
Novelty place preference0.10.10.1-0.1-0.4-0.10.0-0.30.3-0.3-0.4
Time in novel zone, NPP test0.10.10.20.1-0.20.10.2-0.10.1-0.5-0.5
Total zone transitions, NPP test0.10.10.30.10.1-0.00.20.4-0.0-0.5-0.5
Total locomotion distance, NPP test1.62.23.3-1.5-1.7-1.7-1.2-1.81.80.91.1
Locomotion velocity, NPP test1.72.43.6-1.5-1.7-1.7-1.3-1.91.81.01.2
Intraocular pressure0.10.20.70.40.20.50.60.4-0.0-0.2-0.8
Delta distance traveled before/after self-admin1.92.03.0-1.6-1.7-1.6-1.5-1.51.70.80.5
Delta ambulatory time before/after self-admin1.62.03.1-1.6-1.7-1.6-1.4-1.71.80.50.4
Parametrial fat weight0.51.34.4-0.40.6-0.2-1.00.5-0.61.82.1
Pavlov. Cond. lever latency0.50.61.7-0.8-0.5-0.7-1.0-0.60.51.30.4
Pavlov. Cond. magazine entry latency1.11.43.01.51.11.21.70.7-1.0-0.71.0
Pavlov. Cond. change in total contacts1.51.63.81.40.81.21.80.9-0.8-1.9-0.8
Pavlov. Cond. index score1.01.22.61.41.01.21.60.9-1.0-1.00.4
Pavlov. Cond. latency score0.70.92.11.20.81.01.40.7-0.8-1.20.1
Pavlov. Cond. lever contacts0.30.31.10.60.20.50.80.3-0.2-1.0-0.1
Pavlov. Cond. magazine entry number0.91.12.8-1.4-0.9-1.1-1.7-0.50.90.8-0.5
Pavlov. Cond. intertrial magazine entries0.50.61.90.60.80.60.41.4-0.9-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.1.31.73.51.61.21.41.91.0-1.2-1.10.4
Pavlov. Cond. response bias0.60.81.51.10.80.81.20.6-0.7-0.31.2
Pavlov. Cond. lever latency3.44.67.42.42.52.52.22.7-2.4-1.0-0.1
Pavlov. Cond. magazine entry latency2.02.44.8-1.6-1.8-1.7-1.5-2.21.70.80.4
Pavlov. Cond. change in total contacts5.08.012.7-3.0-3.4-3.1-2.7-3.63.41.30.1
Pavlov. Cond. index score4.05.49.3-2.5-2.7-2.6-2.3-3.12.61.20.4
Pavlov. Cond. latency score3.34.47.8-2.3-2.4-2.3-2.0-2.82.31.00.3
Pavlov. Cond. lever contacts3.85.28.3-2.5-2.7-2.6-2.3-2.92.61.10.0
Pavlov. Cond. magazine entry number3.64.47.62.32.32.42.12.7-2.3-1.3-0.6
Pavlov. Cond. intertrial magazine entries0.61.02.21.00.91.10.91.5-1.1-0.6-0.4
Pavlov. Cond. lever-magazine prob. diff.3.95.28.9-2.5-2.6-2.5-2.2-3.02.51.30.6
Pavlov. Cond. response bias4.66.310.1-2.8-3.0-2.9-2.4-3.22.91.2-0.1
Time in closed arm before self-admin1.72.23.51.51.21.51.61.2-1.1-1.9-1.5
Time in closed arm after self-admin0.60.74.00.20.10.20.30.1-0.0-1.1-2.0
Time in open arm before self-admin4.44.86.0-2.3-2.1-2.3-2.3-2.02.02.52.1
Time in open arm after self-admin1.41.53.6-1.1-1.0-1.1-1.1-1.11.01.31.9
Bone: periosteal estimation2.04.35.3-2.3-2.3-2.3-2.1-2.02.22.01.3
Bone: periosteal perimeter1.11.82.1-1.4-1.4-1.4-1.3-1.11.41.41.3
Bone: post-yield work1.31.93.3-1.4-1.8-1.5-1.0-1.81.7-0.3-0.6
Progressive ratio test 1 active lever presses0.40.52.60.4-0.20.30.7-0.20.2-1.6-0.9
Progressive ratio test 1 breakpoint0.50.62.70.4-0.30.20.7-0.20.3-1.6-1.0
Progressive ratio test 1 inactive lever presses1.72.59.20.6-0.20.41.1-0.10.2-3.0-3.0
Progressive ratio test 2 active lever presses0.10.10.30.40.10.30.60.1-0.1-0.5-0.1
Progressive ratio test 2 breakpoint0.20.20.50.50.20.40.70.2-0.2-0.6-0.2
Progressive ratio test 2 inactive lever presses0.91.58.20.1-0.30.10.4-0.30.3-1.8-2.9
Incentive Sensitization - Responses0.10.20.30.50.40.50.60.4-0.4-0.1-0.3
Incentive Sensitization - Breakpoint0.10.20.30.50.40.50.60.4-0.4-0.1-0.4
Sum of active levers in priming session hrs 5-60.00.00.10.00.20.1-0.00.2-0.20.40.1
Progressive ratio0.20.40.60.70.50.60.80.4-0.6-0.8-0.2
Food seeking constrained by brief footshock1.11.41.9-1.3-1.4-1.3-1.1-1.41.40.40.7
Seeking ratio, punishment vs. effort0.30.50.9-0.8-0.8-0.8-0.7-0.80.9-0.0-0.2
Retroperitoneal fat weight0.73.013.00.31.30.4-0.41.4-1.52.33.6
Reaction time number correct0.00.10.2-0.3-0.1-0.3-0.3-0.20.20.50.2
Reaction time mean minus median0.20.50.8-0.9-0.7-0.8-0.9-0.50.80.60.5
Reaction time mean minus median AUC0.61.52.1-1.4-1.2-1.4-1.5-1.11.31.00.9
Reaction time num false alarms0.60.81.11.00.91.01.00.7-0.8-0.9-0.5
Reaction time num false alarms AUC0.71.21.71.31.21.31.20.9-1.0-1.0-0.3
Reaction time trials correct on left0.00.10.2-0.3-0.1-0.3-0.3-0.20.20.50.2
Reaction time trials on left0.10.10.3-0.3-0.1-0.3-0.3-0.20.20.50.3
Reaction time mean0.20.30.6-0.6-0.6-0.6-0.4-0.60.80.10.2
Reaction time mean AUC0.10.20.4-0.4-0.4-0.5-0.3-0.50.60.10.5
Median of all reaction times0.00.00.1-0.1-0.2-0.10.1-0.20.3-0.30.0
Reaction time omissions0.10.21.2-0.20.0-0.2-0.2-0.10.00.51.1
Reaction time false alarm rate0.70.91.31.10.91.21.10.8-0.9-1.1-0.5
Reaction time premature initiation rate0.30.51.70.60.20.60.80.1-0.4-1.3-0.8
Reaction time premature initiations0.20.31.00.50.20.40.60.0-0.3-1.0-0.7
Std. dev. reaction times0.50.91.7-1.0-1.2-1.1-0.9-1.01.30.50.3
Reaction time trials completed0.10.10.3-0.3-0.1-0.3-0.3-0.20.20.50.3
Reaction time trials AUC0.10.20.6-0.3-0.0-0.3-0.4-0.10.10.80.6
Run reversals in cocaine runway, females0.90.91.4-1.0-1.2-1.0-0.9-1.21.10.4-0.6
Run reversals in cocaine runway, males1.21.26.5-0.30.5-0.2-0.70.3-0.41.42.6
Latency to leave start box in cocaine runway0.60.71.5-0.6-0.7-0.6-0.5-1.00.8-0.9-1.2
Latency to leave start box in cocaine runway, F0.50.52.4-0.2-0.3-0.2-0.0-0.40.2-1.2-1.6
Latency to leave start box in cocaine runway, M0.20.10.4-0.2-0.4-0.2-0.1-0.70.6-0.3-0.2
Std. dev. time between licks in bursts0.60.92.40.80.50.81.20.3-0.2-1.6-1.2
Total sessions with >9 infusions0.70.81.41.10.80.91.20.8-0.8-0.70.8
Short access day 1 total inactive lever presses1.52.010.6-0.1-0.7-0.20.3-0.70.7-2.0-3.3
Short access day 10 total inactive lever presses1.02.37.8-1.3-1.4-1.2-1.0-1.51.4-0.8-2.8
Short access day 1 total infusions0.10.20.70.30.00.20.50.1-0.0-0.8-0.4
Short access day 10 total infusions0.40.51.30.80.40.71.00.4-0.3-1.10.2
Short access total infusions0.60.81.51.10.70.91.20.7-0.7-1.10.4
Short access day 1 locomotion0.60.81.01.00.80.91.00.9-0.8-1.0-0.4
Short access day 10 total locomotion0.30.52.70.4-0.20.20.8-0.20.2-1.6-0.7
Short access total locomotion1.72.13.71.71.21.51.81.2-1.2-1.9-0.5
One hour access (0.3 mA shock)0.60.72.2-0.1-0.9-0.30.4-0.80.9-1.5-1.1
Compulsive drug intake0.50.52.20.40.10.30.70.1-0.1-1.5-1.2
One hour access (shock baseline)0.10.10.50.3-0.30.10.5-0.30.3-0.7-0.4
Social response proportion1.01.11.7-1.3-1.0-1.2-1.3-0.81.01.0-0.3
Social responses0.10.10.4-0.5-0.0-0.4-0.6-0.10.20.4-0.1
Social time1.72.33.7-1.7-1.7-1.7-1.4-1.61.90.8-0.6
Soleus weight0.00.10.3-0.00.30.1-0.20.4-0.30.60.2
Bone: stiffness1.32.12.9-1.7-1.6-1.7-1.6-1.61.60.8-0.3
Tibialis anterior weight0.31.04.7-0.8-0.2-0.6-1.20.2-0.02.21.1
Time to tail flick, vehicle, before self-admin0.30.30.60.60.50.50.70.4-0.4-0.8-0.4
Time to tail flick, vehicle, after self-admin0.00.00.10.10.00.10.20.0-0.0-0.30.3
Time to tail flick, test, before self-admin0.90.94.60.0-0.4-0.00.4-0.50.4-1.3-2.1
Time to tail flick, test, after self-admin0.10.20.20.40.50.40.40.5-0.4-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.4-0.6-0.4-0.3-0.50.50.10.4
Delta time to tail flick, test, before/after SA1.11.13.40.61.10.70.31.2-1.10.91.8
Tibia length2.56.99.4-3.0-3.0-3.1-2.8-3.02.81.70.4
Ambulatory time before self-admin0.00.00.0-0.0-0.1-0.00.0-0.00.10.2-0.2
Ambulatory time after self-admin2.73.24.7-1.9-2.1-2.0-1.8-2.02.21.10.3
Bone: tissue strength2.12.13.1-1.5-1.8-1.5-1.3-1.71.8-0.1-1.2
Total heroin consumption0.30.31.1-0.3-0.5-0.3-0.2-0.70.5-0.5-1.0
Bone: trabecular number1.32.23.3-1.6-1.6-1.7-1.6-1.81.60.90.1
Bone: trabecular spacing0.20.31.8-0.2-0.3-0.2-0.3-0.40.20.51.4
Bone: trabecular thickness0.10.10.4-0.4-0.3-0.4-0.4-0.20.30.0-0.6
Bone: trabecular tissue density0.91.34.00.81.20.80.41.4-1.20.82.0
Water consumed over 24 hours0.70.91.1-1.0-1.0-1.0-1.0-1.00.71.00.6
Number of responses in last shaping day0.10.10.3-0.0-0.5-0.20.3-0.50.5-0.40.2