Hub : Genes

Dmkn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr1_86028416_86029802 0.08 0.07 1.5e-04 0.04 0.04 0.05 0.03 2.9e-04 7.2e-05 3.8e-05 7.1e-04
2 NAcc intron excision ratio chr1_86028416_86029802 0.02 0.02 6.1e-03 0.02 0.02 0.03 0.02 8.3e-04 4.0e-03 6.0e-04 9.9e-04
3 BLA gene expression Dmkn 0.18 0.09 4.9e-08 0.16 0.13 0.14 0.14 6.2e-09 2.4e-07 7.0e-08 3.7e-08
4 PL gene expression Dmkn 0.04 0.03 9.2e-05 0.04 0.04 0.04 0.04 4.0e-05 8.9e-05 8.7e-05 6.6e-05
5 Brain gene expression Dmkn 0.05 0.03 4.0e-07 0.03 0.07 0.05 0.06 3.7e-04 3.4e-07 1.7e-05 2.5e-06
6 NAcc gene expression Dmkn 0.03 0.02 2.3e-04 0.03 0.04 0.03 0.03 3.3e-04 4.7e-05 2.6e-04 1.2e-04
7 OFC gene expression Dmkn 0.18 0.13 5.9e-03 0 0.02 -0 -0 2.3e-01 1.1e-01 4.3e-01 4.5e-01
8 NAcc intron excision ratio chr1_86016781_86017367 0.05 0.04 7.8e-03 0.01 0.01 0.01 0.01 3.5e-02 2.3e-02 2.1e-02 1.9e-02
9 Adipose gene expression Dmkn 0.67 0.11 0.0e+00 0.41 0.41 0.42 0.41 1.3e-48 1.6e-49 9.4e-50 3.2e-49

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.22.03.1-1.7-1.81.21.2-1.6-1.5-1.6-0.2-1.4
Area under the delay curve0.30.31.30.20.60.20.20.00.00.21.21.1
BMI with tail0.20.71.31.10.8-0.8-0.80.80.80.90.21.1
BMI without tail0.00.00.10.30.0-0.0-0.0-0.0-0.1-0.1-0.1-0.4
Body weight2.711.514.8-3.8-3.83.63.6-3.7-3.7-3.72.0-1.9
Weight adjusted by age0.30.30.5-0.7-0.70.60.6-0.6-0.6-0.60.3-0.3
Bone surface1.52.74.6-2.1-1.81.91.9-1.5-1.6-1.61.2-0.5
Bone volume1.93.25.8-2.4-2.11.91.9-1.8-1.8-1.90.9-0.9
Breakpoint value in progressive ratio session0.40.52.0-0.5-0.30.60.6-0.5-0.5-0.41.40.6
Number of licking bursts3.33.95.92.22.4-1.7-1.72.32.22.30.21.9
Context. condit. distance diff. score0.40.41.60.20.40.10.10.50.30.41.21.2
Locomotion velocity, session 10.40.42.0-0.5-0.3-0.5-0.50.20.30.1-1.4-0.6
Locomotion distance, session 10.81.04.0-2.0-1.21.01.0-0.5-0.5-0.71.00.5
Locomotion velocity, session 20.60.71.10.30.8-1.1-1.10.91.00.8-0.90.1
Locomotion distance, session 21.11.62.8-0.10.8-1.2-1.21.61.71.50.21.6
Locomotion velocity, session 30.10.20.4-0.20.3-0.4-0.40.60.60.4-0.30.2
Locomotion distance, session 32.02.26.5-1.9-0.81.61.6-0.7-0.8-0.82.51.4
Stereotopy head waving bouts, day 31.01.15.01.00.3-1.1-1.10.10.30.2-2.2-1.3
Stereotopy head waving duration, day 31.41.75.91.30.5-1.6-1.60.50.70.6-2.4-1.2
Locomotion velocity, session 70.60.71.9-1.3-0.60.70.7-0.3-0.3-0.31.41.0
Locomotion distance, session 70.60.72.8-1.7-1.10.70.7-0.5-0.4-0.60.6-0.2
Stereotopy head waving bouts, day 71.92.24.41.82.1-1.1-1.11.71.51.60.31.2
Stereotopy head waving duration, day 72.53.15.12.32.2-1.8-1.81.81.81.8-0.71.1
Locomotion velocity, session 83.54.26.11.72.2-2.0-2.02.52.42.4-0.22.1
Locomotion distance, session 81.21.74.30.21.1-0.7-0.71.71.51.51.32.1
Degree of sensitization distance0.40.42.10.3-0.2-0.4-0.4-0.00.0-0.0-1.2-1.5
Degree of sensitization stereotypy2.62.85.51.92.3-1.1-1.11.91.71.90.71.7
Conditioned locomotion1.11.32.81.71.4-1.1-1.11.11.11.2-0.40.9
Cocaine response after cond. corrected0.40.51.90.70.0-0.3-0.3-0.4-0.2-0.2-1.4-1.1
Cocaine response after cond. not corrected0.80.93.60.3-0.3-0.2-0.2-0.6-0.5-0.6-1.9-1.8
Cocaine response before conditioning1.21.52.9-1.7-1.21.41.4-1.0-1.1-1.30.3-1.2
Saline control response0.10.20.6-0.3-0.50.10.1-0.2-0.2-0.3-0.8-0.8
Bone: connectivity density0.30.51.0-1.0-0.80.60.6-0.7-0.7-0.70.1-0.7
Bone: cortical apparent density1.11.52.20.81.0-1.3-1.31.41.51.4-0.01.2
Bone: cortical area1.42.13.4-1.8-1.71.51.5-1.5-1.5-1.60.4-1.0
Bone: cortical porosity3.33.66.41.82.5-1.6-1.62.22.02.00.42.1
Bone: cortical porosity3.94.37.31.92.7-1.7-1.72.32.22.30.52.4
Bone: cortical thickness0.40.71.0-0.9-1.00.70.7-0.9-0.9-1.0-0.3-1.0
Bone: cortical thickness0.40.41.70.40.2-0.9-0.90.40.50.4-1.3-0.3
Bone: cortical tissue density1.31.82.71.01.2-1.5-1.51.51.61.6-0.11.4
Condit. Reinf. active minus inactive responses0.20.20.50.40.4-0.7-0.70.40.50.5-0.20.5
Condit. Reinf. active-inactive response ratio0.40.41.60.60.0-0.8-0.8-0.10.10.0-1.3-0.6
Condit. Reinf. active responses2.02.53.21.31.5-1.7-1.71.61.81.7-0.31.7
Condit. Reinf. inactive responses2.53.06.30.91.7-1.5-1.52.02.02.10.42.5
Incentive salience index mean0.30.40.80.30.5-0.8-0.80.60.70.6-0.00.9
Condit. Reinf. lever presses0.20.31.60.10.6-0.4-0.40.40.50.50.41.2
Condit. Reinf. active minus inactive responses1.11.33.8-1.9-1.51.11.1-1.0-1.0-1.20.4-0.4
Condit. Reinf. active-inactive response ratio0.00.00.1-0.4-0.2-0.1-0.10.10.10.0-0.30.2
Condit. Reinf. active responses2.33.16.7-2.6-2.01.91.9-1.6-1.7-1.81.2-0.5
Condit. Reinf. inactive responses1.92.44.5-1.7-1.11.91.9-1.3-1.5-1.32.1-0.0
Condit. Reinf. lever presses5.98.013.6-3.7-3.42.92.9-2.9-2.9-3.01.3-1.6
Condit. Reinf. lever reinforcers received2.43.37.1-2.7-1.92.12.1-1.5-1.6-1.71.6-0.3
Conditioned reinforcement - actives0.20.20.4-0.00.6-0.3-0.30.50.50.4-0.20.2
Conditioned reinforcement - inactives1.21.36.0-0.40.70.30.30.60.50.62.12.5
Conditioned locomotion3.03.65.51.72.3-1.7-1.72.12.12.2-0.12.3
Patch foraging indifference point 0 sec0.00.00.10.30.40.10.10.20.10.10.20.2
Patch foraging indifference point AUC0.30.30.50.60.7-0.7-0.70.40.50.5-0.70.1
Delay disc. indifference point, 0s delay1.11.36.3-0.10.60.20.20.40.40.62.02.5
Delay disc. indifference point, 16s delay0.40.41.90.30.50.30.3-0.1-0.10.11.11.4
Delay disc. indifference point, 2s delay1.01.14.3-1.1-0.61.11.1-0.7-0.7-0.52.11.0
Delay disc. indifference point, 24s delay1.21.12.1-1.1-0.61.21.2-1.0-1.0-0.91.40.7
Delay disc. indifference point, 4s delay0.60.61.30.61.1-0.5-0.50.80.80.80.51.1
Delay disc. indifference point, 8s delay0.10.10.60.20.40.30.3-0.1-0.2-0.10.70.2
Indifference point function ln k0.50.61.7-1.3-1.30.70.7-0.5-0.6-0.70.3-0.6
Indifference point function log k0.50.61.7-1.3-1.30.70.7-0.5-0.6-0.70.3-0.6
Patch foraging total patch changes 0 sec0.00.10.20.10.30.30.30.1-0.1-0.00.40.2
Patch foraging total patch changes 12 sec0.20.20.40.50.6-0.6-0.60.20.30.2-0.6-0.2
Patch foraging total patch changes 18 sec0.30.31.10.71.00.20.20.40.30.40.60.8
Patch foraging total patch changes 24 sec0.70.82.8-0.30.11.21.2-0.6-0.7-0.51.70.6
Patch foraging total patch changes 6 sec0.00.00.10.20.4-0.1-0.10.10.10.1-0.3-0.1
Patch foraging time to switch 0 sec0.91.44.52.11.5-1.1-1.10.60.70.9-1.3-0.4
Patch foraging water rate 0 sec0.40.61.3-0.20.2-1.0-1.01.01.10.9-0.20.8
Patch foraging water rate 12 sec0.71.02.6-1.6-1.01.31.3-0.3-0.5-0.61.2-0.3
Patch foraging water rate 18 sec0.10.20.3-0.3-0.1-0.5-0.50.60.60.4-0.4-0.2
Patch foraging water rate 24 sec0.81.14.3-0.80.10.20.21.00.80.72.11.8
Patch foraging water rate 6 sec1.01.53.7-1.9-1.11.41.4-0.5-0.6-0.61.90.6
Seeking ratio, delayed vs. immediate footshock1.01.13.3-1.1-0.51.31.3-0.6-0.7-0.51.81.0
Distance traveled before self-admin0.00.00.2-0.1-0.00.00.00.00.00.00.0-0.5
Distance traveled after self-admin2.32.53.5-1.8-1.41.91.9-1.5-1.7-1.61.6-0.7
Extensor digitorum longus weight0.10.62.3-0.1-1.1-0.2-0.2-0.8-0.4-0.5-1.5-0.6
Bone: elastic displacement0.10.20.90.20.1-0.0-0.0-0.2-0.2-0.2-0.5-0.9
Bone: elastic work1.52.02.8-1.5-1.41.41.4-1.7-1.6-1.60.5-1.1
Bone: endosteal estimation1.22.74.5-2.1-1.81.91.9-1.5-1.6-1.71.0-0.7
Bone: endosteal perimeter0.91.92.9-1.7-1.41.71.7-1.1-1.3-1.31.3-0.3
Epididymis fat weight0.20.51.2-1.1-0.80.60.6-0.4-0.4-0.51.10.0
Delta time in closed arm before/after self-admin2.72.73.8-1.7-1.61.81.8-1.9-1.9-1.90.6-0.9
Delta time in open arm before/after self-admin0.50.50.70.60.5-0.9-0.90.80.80.7-0.80.0
Diff in mean of infusions in LGA sessions1.41.52.81.71.5-1.0-1.01.31.21.40.31.2
Delay discount exponential model param0.20.21.2-0.1-0.4-0.3-0.30.10.10.0-1.1-0.8
Extinction: sum of active levers before priming3.43.45.1-1.8-2.01.81.8-2.3-2.2-2.10.6-1.6
Active lever presses in extinction session 63.63.56.5-1.6-1.81.41.4-2.3-2.1-2.2-0.8-2.6
Bone: final force1.32.13.3-1.8-1.51.61.6-1.5-1.5-1.61.2-0.2
Bone: final moment1.83.04.7-2.2-1.81.91.9-1.8-1.8-1.91.3-0.3
Food consumed during 24 hour testing period0.40.52.8-0.6-0.10.80.8-0.1-0.3-0.21.70.4
Glucose0.10.21.20.20.0-0.1-0.1-0.0-0.0-0.1-0.7-1.1
Heart weight0.30.51.3-1.0-0.60.50.5-0.1-0.1-0.11.11.1
Delay discount hyperbolic model param0.30.31.3-0.1-0.4-0.2-0.20.10.1-0.0-1.1-0.9
Intermittent access intake day 1-15 change2.42.33.2-1.5-1.51.81.8-1.7-1.7-1.61.1-0.6
Intermittent access intake escalation2.22.23.1-1.5-1.41.81.8-1.6-1.6-1.51.3-0.2
Intermittent access intake escalation 21.31.31.9-0.9-1.01.31.3-1.3-1.4-1.30.5-0.9
Intermitt. access day 1 inactive lever presses1.51.62.5-1.2-1.21.31.3-1.6-1.5-1.41.0-0.0
Intermitt. access day 15 inactive lever presses0.30.42.30.00.20.20.2-0.1-0.00.11.01.5
Intermitt. access escalation Index0.50.41.40.40.5-0.1-0.10.70.60.60.71.2
Intermittent access day 1 total infusions3.54.06.31.72.5-1.4-1.42.52.32.40.62.5
Intermittent access day 15 total infusions1.21.45.00.41.30.10.11.10.81.01.72.2
Intermittent access terminal intake (last 3 days)1.61.84.60.81.6-0.4-0.41.61.31.41.32.1
Intermittent access total infusions2.02.24.81.11.9-0.5-0.51.91.51.71.12.2
Intermittent access day 1 locomotion3.03.26.81.42.2-1.1-1.12.01.92.01.12.6
Intermittent access day 15 total locomotion1.11.24.10.21.00.10.11.00.80.91.72.0
Intermittent access total locomotion2.52.84.71.52.2-1.2-1.22.01.81.90.72.1
Intermittent access standard deviation2.93.05.3-1.6-1.02.32.3-1.5-1.8-1.62.30.4
Left kidney weight3.910.915.2-3.5-3.83.23.2-3.9-3.7-3.70.8-2.8
Right kidney weight5.816.321.6-4.4-4.64.04.0-4.6-4.5-4.51.3-3.2
Cocaine induced anxiety0.40.51.0-0.7-0.90.50.5-1.0-0.9-0.8-0.0-0.3
Post-drug Anxiety0.20.20.70.70.3-0.7-0.7-0.10.10.2-0.80.1
Baseline Anxiety1.81.93.11.71.7-1.4-1.41.41.41.5-0.31.2
Tail length4.112.515.7-3.8-3.83.73.7-3.8-3.9-4.01.2-3.1
Length with tail7.326.736.6-6.0-5.55.65.6-5.4-5.5-5.62.9-3.2
Length without tail5.612.319.9-4.5-3.83.83.8-3.6-3.6-3.62.7-1.1
Times rat made contact with spout0.30.41.5-0.3-0.6-0.2-0.2-0.1-0.1-0.2-1.1-1.2
Lifetime Intake1.31.52.70.81.5-0.6-0.61.61.41.40.61.6
Liver weight, left0.20.31.40.2-0.2-0.8-0.8-0.00.2-0.0-1.2-0.6
Liver weight, right0.20.31.0-0.5-0.3-0.7-0.70.00.2-0.0-1.0-0.6
Locomotor activity0.71.14.7-0.2-0.5-1.0-1.00.10.3-0.0-2.2-1.7
Locomotor testing distance0.40.62.7-0.1-0.2-0.7-0.70.40.40.2-1.6-1.4
Locomotor testing rearing0.71.21.80.50.6-1.3-1.31.41.31.1-1.3-0.3
Locomotion in novel chamber0.50.61.01.00.6-1.0-1.00.60.60.5-1.0-0.2
Locomotion in novel chamber post-restriction0.10.10.30.30.0-0.4-0.40.10.20.2-0.5-0.1
Fecal boli incidents, locomotor time 12.62.94.22.01.9-2.1-2.11.41.61.5-1.70.3
Change in fecal boli incidents, locomotor task0.70.61.7-0.4-0.80.00.0-0.9-0.7-0.8-1.2-1.3
Time >=10cm from walls, locomotor time 10.00.00.10.20.1-0.3-0.30.00.10.0-0.40.2
Bouts of movement, locomotor time 10.60.73.4-0.70.20.60.60.1-0.00.11.91.1
Total resting periods, locomotor time 10.40.42.3-0.40.30.50.50.10.00.11.50.9
Rest time, locomotor task time 11.31.42.31.31.1-1.5-1.50.81.11.1-1.20.6
Distance moved, locomotor task time 10.40.40.8-0.6-0.80.90.9-0.2-0.3-0.30.9-0.4
Vertical activity count, locomotor time 11.91.93.2-1.5-1.41.81.8-1.1-1.2-1.21.5-0.5
Time >=10cm from walls, locomotor time 22.02.13.01.31.6-1.7-1.71.51.61.5-0.70.8
Bouts of movement, locomotor time 20.10.10.2-0.20.20.10.10.40.20.20.5-0.0
Total resting periods, locomotor time 20.10.10.30.10.4-0.2-0.20.50.40.30.0-0.2
Rest time, locomotor task time 20.80.91.31.01.0-1.1-1.10.80.90.8-1.10.1
Distance moved, locomotor task time 20.20.21.1-0.4-0.20.40.40.30.20.11.00.3
Vertical activity count, locomotor time 21.01.12.7-1.2-0.91.31.3-0.7-0.8-0.71.60.2
Light reinforcement 10.20.30.60.10.5-0.3-0.30.80.70.70.30.7
Light reinforcement 21.82.44.41.00.8-2.1-2.11.61.91.6-1.11.0
Bone: marrow area1.22.74.3-2.1-1.81.91.9-1.5-1.7-1.70.9-0.8
Bone: maximum diameter1.12.02.6-1.6-1.61.51.5-1.5-1.5-1.60.6-0.7
Bone: maximum force2.23.85.8-2.4-2.12.12.1-2.0-2.0-2.01.6-0.3
Bone: maximum moment2.74.77.4-2.7-2.32.42.4-2.2-2.2-2.31.7-0.4
Mean time between licks in bursts0.10.10.4-0.3-0.1-0.4-0.40.40.40.30.40.7
Mean num. licks in bursts3.03.66.3-2.2-2.51.31.3-2.0-1.9-2.1-0.8-2.2
Cd content in liver0.20.20.40.00.10.60.6-0.3-0.5-0.4-0.0-0.6
Co content in liver0.30.40.70.80.4-0.8-0.80.40.50.5-0.60.4
Cu content in liver0.60.71.2-1.1-1.00.80.8-0.9-0.8-0.80.80.1
Fe content in liver0.10.10.10.30.4-0.2-0.20.30.30.3-0.00.4
K content in liver0.00.00.10.10.2-0.3-0.30.20.20.2-0.10.1
Mg content in liver0.60.71.50.40.3-1.2-1.20.60.80.7-1.10.2
Mn content in liver1.31.43.11.31.0-1.4-1.40.90.90.8-1.8-0.8
Na content in liver0.80.91.8-1.0-0.51.31.3-0.7-0.8-0.71.40.1
Rb content in liver0.50.62.80.60.5-0.6-0.60.50.60.70.61.7
Se content in liver5.36.410.82.52.2-3.3-3.32.42.72.5-2.30.9
Sr content in liver0.70.61.10.70.6-1.0-1.00.70.80.6-1.1-0.4
Zn content in liver0.10.10.50.10.0-0.6-0.60.10.30.3-0.20.7
Bone: minimum diameter1.73.25.3-2.1-1.52.32.3-1.5-1.7-1.61.9-0.0
Time in familiar zone, hab. session 12.52.35.2-1.9-2.30.90.9-1.7-1.4-1.6-0.8-1.5
Time in novel zone, hab. session 13.63.66.52.22.5-1.6-1.62.22.02.10.41.5
Total zone transitions, hab. session 10.20.21.0-0.60.10.00.00.50.40.30.61.0
Total locomotion distance, hab. session 10.20.30.5-0.7-0.00.70.7-0.1-0.4-0.40.6-0.3
Locomotion velocity, hab. session 10.10.20.5-0.50.00.50.5-0.1-0.3-0.40.1-0.7
Time in familiar zone, hab. session 21.41.42.9-0.4-1.20.90.9-1.5-1.4-1.4-0.5-1.7
Time in novel zone, hab. session 20.70.71.10.30.9-0.8-0.81.11.11.00.00.9
Total zone transitions, hab. session 22.73.45.71.21.6-2.1-2.12.42.42.1-0.81.1
Total locomotion distance, hab. session 20.70.91.90.71.1-0.8-0.81.41.21.10.40.7
Locomotion velocity, hab. session 20.60.81.80.71.0-0.9-0.91.31.21.10.20.5
Novel to familiar place preference ratio0.10.10.5-0.10.00.40.4-0.1-0.2-0.10.70.5
Novelty place preference0.10.10.60.00.20.30.30.1-0.10.00.80.5
Time in novel zone, NPP test0.20.20.60.10.30.20.20.30.20.20.80.7
Total zone transitions, NPP test0.10.10.6-0.7-0.3-0.1-0.10.20.20.1-0.10.2
Total locomotion distance, NPP test1.62.23.5-1.9-1.51.61.6-1.3-1.5-1.60.6-1.3
Locomotion velocity, NPP test1.62.23.0-1.7-1.51.61.6-1.4-1.5-1.60.4-1.5
Intraocular pressure0.30.41.51.20.9-0.1-0.10.60.40.60.50.6
Delta distance traveled before/after self-admin3.13.34.6-1.9-1.72.12.1-1.8-2.0-1.91.7-0.3
Delta ambulatory time before/after self-admin3.63.95.9-2.1-1.72.42.4-1.9-2.1-2.01.9-0.4
Parametrial fat weight1.32.47.4-0.7-1.6-0.3-0.3-1.4-1.0-1.3-2.6-2.7
Pavlov. Cond. lever latency0.50.61.2-0.3-0.90.80.8-1.1-1.0-0.80.2-0.5
Pavlov. Cond. magazine entry latency0.60.81.80.20.6-0.9-0.91.31.10.8-0.8-0.8
Pavlov. Cond. change in total contacts1.11.22.60.41.3-0.8-0.81.61.41.30.61.2
Pavlov. Cond. index score0.81.12.30.40.9-1.1-1.11.51.41.1-0.7-0.2
Pavlov. Cond. latency score0.60.81.80.30.9-0.9-0.91.31.21.0-0.40.1
Pavlov. Cond. lever contacts0.20.20.50.00.5-0.4-0.40.70.60.5-0.00.3
Pavlov. Cond. magazine entry number0.70.92.3-0.3-0.81.01.0-1.5-1.3-1.00.60.5
Pavlov. Cond. intertrial magazine entries0.20.30.60.00.1-0.7-0.70.40.60.6-0.20.7
Pavlov. Cond. lever-magazine prob. diff.1.11.32.90.61.1-1.3-1.31.71.51.3-0.7-0.1
Pavlov. Cond. response bias0.40.50.8-0.10.3-0.7-0.70.90.80.5-0.9-0.8
Pavlov. Cond. lever latency3.85.18.93.02.5-2.5-2.52.22.32.3-1.70.6
Pavlov. Cond. magazine entry latency1.41.62.7-1.6-1.41.41.4-1.3-1.3-1.30.8-0.5
Pavlov. Cond. change in total contacts5.67.711.4-3.1-2.63.43.4-2.6-2.8-2.62.8-0.4
Pavlov. Cond. index score3.64.68.0-2.8-2.32.52.5-2.1-2.2-2.11.6-0.6
Pavlov. Cond. latency score3.24.06.7-2.6-2.12.32.3-1.9-2.0-2.01.6-0.5
Pavlov. Cond. lever contacts3.54.77.9-2.8-2.32.52.5-2.1-2.1-2.11.9-0.4
Pavlov. Cond. magazine entry number3.54.38.02.82.3-2.3-2.32.02.02.1-1.30.8
Pavlov. Cond. intertrial magazine entries0.70.92.41.51.1-0.9-0.90.80.80.9-0.70.5
Pavlov. Cond. lever-magazine prob. diff.3.74.88.3-2.9-2.42.42.4-2.1-2.2-2.21.4-0.8
Pavlov. Cond. response bias4.15.59.8-3.1-2.52.72.7-2.1-2.2-2.22.1-0.3
Time in closed arm before self-admin3.03.45.51.82.3-1.7-1.72.12.02.1-0.01.9
Time in closed arm after self-admin0.20.21.10.20.6-0.1-0.10.10.10.20.51.0
Time in open arm before self-admin4.54.96.4-2.1-2.52.22.2-2.4-2.4-2.50.2-2.5
Time in open arm after self-admin1.31.52.5-1.3-1.41.21.2-1.1-1.2-1.30.1-1.6
Bone: periosteal estimation1.83.86.3-2.5-2.32.12.1-1.9-2.0-2.10.8-1.1
Bone: periosteal perimeter1.01.72.2-1.5-1.51.41.4-1.3-1.3-1.40.2-1.2
Bone: post-yield work1.21.64.9-1.4-0.81.51.5-0.7-0.9-0.82.20.9
Progressive ratio test 1 active lever presses0.70.83.0-0.40.40.80.80.30.10.21.71.4
Progressive ratio test 1 breakpoint0.60.72.5-0.70.01.01.0-0.1-0.3-0.11.61.1
Progressive ratio test 1 inactive lever presses1.01.14.8-0.30.60.30.30.50.40.51.92.2
Progressive ratio test 2 active lever presses0.50.51.5-0.10.70.30.30.70.50.61.21.2
Progressive ratio test 2 breakpoint0.40.41.2-0.10.70.20.20.80.60.61.01.1
Progressive ratio test 2 inactive lever presses1.82.110.10.11.00.30.30.80.60.82.43.2
Incentive Sensitization - Responses0.10.10.3-0.30.20.00.00.50.40.40.50.5
Incentive Sensitization - Breakpoint0.10.10.2-0.30.10.10.10.40.30.30.50.4
Sum of active levers in priming session hrs 5-60.10.10.2-0.4-0.30.30.3-0.5-0.4-0.40.2-0.3
Progressive ratio0.10.10.20.30.4-0.2-0.20.40.30.3-0.20.2
Food seeking constrained by brief footshock1.61.92.8-1.6-1.21.71.7-1.4-1.5-1.50.8-0.8
Seeking ratio, punishment vs. effort0.40.51.1-1.0-0.60.80.8-0.6-0.6-0.60.80.2
Retroperitoneal fat weight0.51.63.81.00.4-1.8-1.80.81.00.8-1.9-1.1
Reaction time number correct0.10.20.8-0.9-0.80.10.1-0.3-0.2-0.3-0.1-0.4
Reaction time mean minus median0.40.50.9-0.3-0.60.80.8-0.9-0.9-0.90.5-0.7
Reaction time mean minus median AUC1.11.42.2-0.8-1.11.21.2-1.4-1.5-1.40.6-1.2
Reaction time num false alarms0.81.12.61.61.4-0.9-0.91.00.91.1-0.30.6
Reaction time num false alarms AUC1.11.53.51.91.7-1.1-1.11.21.11.2-0.50.5
Reaction time trials correct on left0.10.20.8-0.9-0.80.10.1-0.3-0.2-0.3-0.1-0.4
Reaction time trials on left0.20.20.8-0.9-0.80.10.1-0.3-0.2-0.3-0.1-0.5
Reaction time mean0.20.30.4-0.4-0.30.70.7-0.4-0.6-0.50.6-0.3
Reaction time mean AUC0.10.10.2-0.2-0.20.40.4-0.3-0.5-0.40.3-0.4
Median of all reaction times0.00.10.2-0.1-0.00.40.4-0.0-0.2-0.20.4-0.1
Reaction time omissions0.10.10.60.2-0.3-0.1-0.1-0.2-0.2-0.3-0.6-0.8
Reaction time false alarm rate1.11.54.02.01.8-0.9-0.91.11.01.2-0.20.7
Reaction time premature initiation rate0.40.51.00.61.0-0.2-0.20.80.60.70.81.0
Reaction time premature initiations0.20.30.60.20.5-0.2-0.20.60.50.60.70.8
Std. dev. reaction times0.60.81.3-0.5-0.61.11.1-0.9-1.1-0.91.2-0.4
Reaction time trials completed0.20.20.8-0.9-0.80.10.1-0.3-0.2-0.3-0.1-0.5
Reaction time trials AUC0.20.30.9-0.9-0.90.00.0-0.4-0.3-0.4-0.4-0.7
Run reversals in cocaine runway, females0.80.81.3-0.9-0.81.11.1-0.8-0.8-0.71.10.1
Run reversals in cocaine runway, males1.31.24.9-0.3-0.6-0.5-0.5-0.7-0.5-0.8-2.2-2.0
Latency to leave start box in cocaine runway0.40.41.6-0.3-0.00.60.6-0.3-0.3-0.11.31.1
Latency to leave start box in cocaine runway, F0.30.42.0-0.40.10.20.20.00.10.11.11.4
Latency to leave start box in cocaine runway, M0.10.10.20.50.20.40.4-0.2-0.3-0.10.1-0.3
Std. dev. time between licks in bursts0.81.02.70.51.2-0.3-0.31.10.90.91.21.6
Total sessions with >9 infusions0.70.81.50.61.0-0.9-0.91.21.11.0-0.60.3
Short access day 1 total inactive lever presses1.51.78.10.10.8-0.0-0.00.80.70.92.02.8
Short access day 10 total inactive lever presses0.70.81.8-0.9-0.80.80.8-0.8-0.8-0.71.30.9
Short access day 1 total infusions0.20.20.4-0.50.1-0.2-0.20.60.50.40.20.7
Short access day 10 total infusions0.40.50.90.60.9-0.4-0.40.90.80.80.00.7
Short access total infusions0.50.61.20.40.8-0.7-0.71.11.00.9-0.50.4
Short access day 1 locomotion0.20.20.40.30.5-0.4-0.40.50.50.5-0.10.6
Short access day 10 total locomotion0.40.42.0-0.10.60.50.50.30.10.21.40.9
Short access total locomotion1.21.31.91.01.4-1.1-1.11.31.31.3-0.21.0
One hour access (0.3 mA shock)0.80.93.6-0.90.21.11.10.40.00.11.91.0
Compulsive drug intake0.10.10.5-0.7-0.30.20.2-0.2-0.1-0.2-0.0-0.1
One hour access (shock baseline)0.50.61.40.20.90.10.10.90.60.71.11.2
Social response proportion1.01.11.6-1.0-1.21.01.0-1.2-1.2-1.11.0-0.0
Social responses0.10.20.4-0.6-0.60.10.1-0.6-0.4-0.5-0.10.2
Social time2.22.95.3-2.3-1.91.91.9-1.4-1.5-1.51.80.2
Soleus weight0.00.10.70.1-0.2-0.4-0.40.00.20.1-0.8-0.2
Bone: stiffness1.32.13.8-1.9-1.81.41.4-1.4-1.3-1.41.30.1
Tibialis anterior weight0.31.02.0-0.3-1.20.30.3-1.2-0.9-1.0-1.4-1.3
Time to tail flick, vehicle, before self-admin0.70.71.20.60.5-1.1-1.11.01.11.0-0.20.7
Time to tail flick, vehicle, after self-admin0.30.30.80.90.9-0.5-0.50.50.40.4-0.6-0.0
Time to tail flick, test, before self-admin1.31.34.3-0.10.8-0.1-0.11.00.90.91.92.1
Time to tail flick, test, after self-admin0.00.00.2-0.3-0.1-0.0-0.00.20.20.10.50.1
Delta time to tail flick, vehicle, before/after SA0.20.20.30.30.50.60.6-0.3-0.5-0.40.1-0.3
Delta time to tail flick, test, before/after SA0.90.83.60.3-0.3-0.6-0.6-0.2-0.1-0.2-1.9-1.7
Tibia length3.29.014.3-3.8-3.53.23.2-3.0-3.0-3.12.2-1.0
Ambulatory time before self-admin0.10.10.10.30.3-0.2-0.20.20.20.3-0.0-0.3
Ambulatory time after self-admin4.34.86.7-2.4-1.82.62.6-2.1-2.3-2.12.5-0.4
Bone: tissue strength2.42.35.5-1.5-1.01.81.8-1.3-1.4-1.32.30.9
Total heroin consumption0.20.21.0-0.10.20.40.4-0.1-0.10.01.00.6
Bone: trabecular number1.62.54.2-2.0-1.81.71.7-1.6-1.6-1.61.2-0.5
Bone: trabecular spacing0.20.31.10.50.30.10.1-0.2-0.3-0.3-0.9-1.0
Bone: trabecular thickness0.20.20.9-0.9-0.70.30.3-0.4-0.3-0.30.10.1
Bone: trabecular tissue density1.21.77.80.80.1-1.4-1.40.50.70.5-2.8-1.5
Water consumed over 24 hours0.70.92.0-1.4-1.40.80.8-0.9-0.8-0.90.4-0.6
Number of responses in last shaping day0.91.03.0-0.10.9-0.1-0.11.21.00.91.31.7