Dmc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	isoform ratio	NM_001130567.1	0.02	0.01	4.1e-03	0	0.01	0	0	5.6e-02	8.4e-03	5.2e-02	6.4e-02
2	NAcc	isoform ratio	XM_039079586.2	0.02	0.01	6.1e-03	0	0.01	0	0	6.7e-02	1.7e-02	1.1e-01	1.4e-01
3	NAcc	alternative TSS	XM_039079586.2	0.02	0.01	3.5e-03	0	0.01	0	0	1.5e-01	2.7e-02	2.6e-01	2.1e-01
4	BLA	mRNA stability	Dmc1	0.09	0.05	4.4e-03	0	0.04	0.05	0	2.5e-01	4.9e-03	1.2e-03	1.6e-01
5	NAcc	alternative TSS	NM_001130567.1	0.02	0.01	4.1e-03	0.01	0.01	0	0	2.0e-02	2.2e-02	2.5e-01	1.7e-01
6	PL	isoform ratio	XM_039079586.2	0.04	0.03	4.5e-03	0.02	0.01	0.01	0.02	1.3e-03	8.2e-03	4.6e-02	6.8e-03
7	NAcc	gene expression	Dmc1	0.11	0.04	3.2e-14	0.12	0.1	0.11	0.12	2.6e-17	3.7e-15	1.8e-16	4.5e-17
8	PL	gene expression	Dmc1	0.06	0.03	9.8e-06	0.07	0.04	0.04	0.05	7.7e-08	2.1e-05	1.0e-05	1.6e-06
9	BLA	gene expression	Dmc1	0.09	0.05	6.6e-04	0.03	0.06	0.05	0.05	1.2e-02	6.8e-04	1.6e-03	8.0e-04
10	IC	gene expression	Dmc1	0.28	0.11	6.3e-06	0.1	0.07	0.06	0.12	3.9e-05	5.9e-04	1.1e-03	9.7e-06
11	OFC	alternative TSS	XM_039079586.2	0.18	0.11	7.0e-03	0.02	-0.01	0.02	0.01	8.9e-02	7.1e-01	9.3e-02	1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.0	0.0	0.2	0.1	-0.1	-0.0	0.1	-0.1	0.4	0.0	-0.2	0.2	0.1	0.0
Area under the delay curve	1.9	3.0	5.6	2.3	-2.3	-2.3	2.4	-2.4	1.8	0.8	0.5	0.7	-0.6	0.7
BMI with tail	0.5	1.7	3.7	-1.6	1.6	1.6	-1.7	1.6	-1.9	-0.9	0.1	-0.1	1.0	-0.1
BMI without tail	0.3	1.5	3.1	-1.8	1.7	1.6	-1.5	1.2	-0.6	-1.1	-0.4	-0.1	1.1	-1.2
Body weight	1.2	5.1	11.1	-2.9	2.8	2.7	-3.3	3.2	-2.5	-0.2	0.5	-1.8	0.3	-1.4
Weight adjusted by age	0.2	0.6	1.3	-1.1	1.1	1.0	-0.8	0.6	-0.1	-0.6	-0.8	0.0	0.5	0.4
Bone surface	0.1	0.3	0.8	0.6	-0.6	-0.5	0.3	-0.2	0.7	0.4	-0.0	-0.1	-0.6	0.9
Bone volume	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.0	0.1	0.0	-0.3	0.2	-0.0	0.2
Breakpoint value in progressive ratio session	0.1	0.2	0.5	0.5	-0.5	-0.5	0.3	0.2	-0.1	0.7	0.6	-0.2	-0.6	0.5
Number of licking bursts	0.2	0.6	2.0	0.6	-0.6	-0.8	0.9	-1.1	1.4	-0.6	-0.1	0.8	0.4	0.1
Context. condit. distance diff. score	5.1	6.2	10.6	-3.2	3.2	3.2	-3.3	3.2	-3.1	-1.4	-1.2	-0.4	1.1	-1.6
Locomotion velocity, session 1	0.9	1.0	2.0	0.7	-0.8	-0.8	0.5	-1.0	1.2	1.1	1.4	-1.3	-1.3	0.5
Locomotion distance, session 1	2.9	3.7	7.4	2.4	-2.3	-2.4	2.5	-2.5	2.7	0.2	0.2	0.9	-0.5	1.5
Locomotion velocity, session 2	0.6	0.8	6.2	0.7	-0.7	-0.4	0.3	-0.2	-0.3	0.4	0.6	-0.2	-0.4	2.5
Locomotion distance, session 2	4.6	6.5	11.4	3.4	-3.3	-3.3	3.1	-3.1	3.1	1.6	1.2	0.1	-1.6	1.8
Locomotion velocity, session 3	2.4	2.8	4.9	-2.1	2.1	2.1	-1.9	1.5	-1.3	-1.6	-2.2	0.7	1.5	-0.1
Locomotion distance, session 3	1.7	1.9	6.4	-0.7	0.8	0.6	-0.1	0.1	0.4	-2.2	-2.5	2.2	1.9	-0.2
Stereotopy head waving bouts, day 3	0.7	0.8	2.8	0.1	-0.2	-0.2	-0.4	0.4	-0.1	1.4	1.4	-1.7	-1.1	0.4
Stereotopy head waving duration, day 3	1.5	1.8	5.9	-0.7	0.6	0.8	-1.2	1.3	-1.2	1.5	1.9	-2.4	-1.3	0.6
Locomotion velocity, session 7	0.4	0.4	1.8	-0.8	0.8	0.8	-0.4	0.7	-1.3	-0.3	-0.4	-0.3	0.1	0.0
Locomotion distance, session 7	0.4	0.6	2.1	0.2	-0.3	-0.5	0.6	-0.2	0.3	0.8	0.6	-1.0	-1.1	-1.5
Stereotopy head waving bouts, day 7	3.2	3.7	6.9	-2.4	2.4	2.6	-2.1	2.4	-2.5	-1.3	-0.8	-0.1	1.4	1.3
Stereotopy head waving duration, day 7	3.2	3.9	7.9	-2.3	2.3	2.7	-2.1	2.3	-2.8	-1.5	-0.8	0.2	1.6	1.4
Locomotion velocity, session 8	0.7	0.8	2.3	-0.6	0.6	0.7	-1.1	1.4	-0.9	0.8	0.6	-1.5	-0.8	0.2
Locomotion distance, session 8	0.5	0.7	1.3	-1.0	1.0	1.1	-0.9	1.0	-1.0	-0.6	-1.0	0.1	0.4	-0.0
Degree of sensitization distance	2.6	2.8	8.9	0.0	-0.2	-0.0	-0.1	0.5	-0.9	2.5	2.5	-3.0	-2.4	-1.5
Degree of sensitization stereotypy	2.8	3.2	5.8	-2.1	2.1	2.4	-1.7	2.0	-2.3	-1.4	-0.9	0.3	1.5	1.7
Conditioned locomotion	0.3	0.3	0.7	-0.7	0.6	0.6	-0.7	0.8	-0.6	0.4	0.0	-0.8	-0.2	0.4
Cocaine response after cond. corrected	0.5	0.8	1.8	0.7	-0.8	-0.6	0.4	-0.5	0.2	1.2	1.2	-1.1	-1.2	1.3
Cocaine response after cond. not corrected	0.3	0.4	1.7	0.6	-0.6	-0.4	0.2	-0.3	-0.1	0.9	0.5	-0.6	-0.9	1.3
Cocaine response before conditioning	0.6	0.7	2.4	-0.4	0.4	0.4	-0.4	0.2	-0.4	-1.1	-1.6	1.3	1.2	-0.3
Saline control response	0.8	1.1	2.3	-1.3	1.3	1.3	-1.5	0.6	-0.9	-0.5	-1.5	0.4	0.6	-0.5
Bone: connectivity density	0.1	0.1	0.3	-0.2	0.1	0.1	-0.3	0.4	0.2	0.4	0.0	-0.5	-0.5	-0.1
Bone: cortical apparent density	1.3	2.0	4.5	-1.5	1.6	1.3	-1.1	0.2	-0.1	-2.1	-1.6	1.6	1.9	-0.9
Bone: cortical area	0.5	0.8	1.7	0.6	-0.7	-0.5	0.1	-0.5	-0.4	1.3	1.3	-1.2	-1.3	1.1
Bone: cortical porosity	0.5	0.6	1.9	0.4	-0.4	-0.0	-0.1	0.5	-1.4	1.0	0.1	-1.0	-1.1	0.7
Bone: cortical porosity	1.2	1.3	3.3	0.5	-0.5	-0.1	-0.2	0.6	-1.6	1.7	0.9	-1.8	-1.7	1.0
Bone: cortical thickness	0.5	0.8	2.4	1.2	-1.2	-1.2	0.7	-1.5	0.3	0.6	0.4	0.1	-0.7	0.6
Bone: cortical thickness	1.7	2.0	4.2	1.9	-1.9	-2.0	1.3	-2.1	1.2	0.9	1.1	-0.1	-1.1	0.6
Bone: cortical tissue density	1.1	1.8	4.0	-1.5	1.5	1.2	-1.1	0.2	-0.1	-2.0	-1.5	1.5	1.8	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.2	1.1	-0.1	0.1	-0.2	-0.1	-0.3	0.6	-0.0	0.1	0.1	-0.2	-1.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.3	-0.9	0.9	0.7	-0.8	0.3	-0.5	-0.6	-0.4	0.3	0.3	-1.1
Condit. Reinf. active responses	0.5	0.6	3.8	-0.4	0.4	0.1	-0.1	-0.2	0.9	-0.7	-0.6	0.8	0.5	-1.9
Condit. Reinf. inactive responses	0.8	1.0	4.5	-0.5	0.5	0.3	0.0	-0.0	0.8	-1.1	-1.2	1.1	1.1	-2.1
Incentive salience index mean	0.2	0.3	2.0	-0.1	0.1	-0.2	0.1	-0.3	0.9	-0.2	-0.2	0.2	-0.0	-1.4
Condit. Reinf. lever presses	0.2	0.3	2.4	-0.2	0.2	-0.1	0.0	-0.0	0.7	-0.4	-0.6	0.3	0.3	-1.5
Condit. Reinf. active minus inactive responses	1.2	1.9	2.9	1.6	-1.6	-1.7	1.2	-1.3	1.2	1.5	1.6	-0.8	-1.7	-0.4
Condit. Reinf. active-inactive response ratio	0.9	1.4	3.7	1.1	-1.1	-1.1	0.6	-0.7	0.7	1.4	1.9	-1.2	-1.7	-0.0
Condit. Reinf. active responses	1.1	1.5	2.7	1.4	-1.5	-1.4	1.0	-1.0	0.5	1.6	1.4	-0.9	-1.6	0.2
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.9	-0.9	-0.9	0.9	-0.6	-0.1	0.7	0.2	-0.1	-0.6	0.6
Condit. Reinf. lever presses	0.3	0.5	1.4	0.8	-0.8	-0.8	0.8	-0.4	0.9	0.7	0.3	0.1	-0.3	-1.2
Condit. Reinf. lever reinforcers received	1.1	1.6	3.2	1.4	-1.4	-1.4	1.0	-0.9	0.5	1.8	1.5	-1.1	-1.7	0.1
Conditioned reinforcement - actives	0.7	2.6	5.5	2.3	-2.3	-2.4	1.8	-1.9	1.3	1.3	1.0	0.0	-1.0	0.9
Conditioned reinforcement - inactives	1.7	4.7	9.4	2.8	-2.8	-3.1	2.3	-2.1	2.7	1.5	1.9	-0.3	-1.6	-0.2
Conditioned locomotion	2.2	3.3	5.5	2.3	-2.4	-2.2	1.2	-1.8	0.8	2.1	2.1	-1.2	-1.9	1.3
Patch foraging indifference point 0 sec	0.1	0.3	1.0	-0.2	0.2	0.0	-0.4	-0.1	0.5	0.9	0.5	-0.8	-0.7	-1.0
Patch foraging indifference point AUC	0.9	2.2	5.7	1.7	-1.7	-2.0	2.1	-2.0	2.4	0.6	0.5	0.2	-0.4	-0.1
Delay disc. indifference point, 0s delay	0.3	0.4	1.1	0.6	-0.6	-0.5	-0.2	-0.2	-0.4	1.1	0.8	-0.6	-1.0	0.2
Delay disc. indifference point, 16s delay	2.3	3.2	7.1	2.4	-2.3	-2.3	2.7	-2.5	2.0	0.7	0.2	0.8	-0.5	1.0
Delay disc. indifference point, 2s delay	3.8	4.2	8.9	3.0	-2.9	-2.6	2.5	-2.7	1.0	0.7	0.6	1.2	-0.6	2.3
Delay disc. indifference point, 24s delay	0.6	1.0	3.1	0.9	-1.0	-1.2	1.3	-1.0	1.8	0.6	0.5	-0.4	-0.5	0.7
Delay disc. indifference point, 4s delay	1.6	1.7	3.3	1.8	-1.7	-1.6	1.6	-1.8	1.3	0.7	0.6	0.3	-0.8	0.8
Delay disc. indifference point, 8s delay	1.2	2.0	4.1	1.7	-1.7	-1.9	1.9	-2.0	2.0	0.4	0.2	0.6	-0.3	-0.6
Indifference point function ln k	1.0	3.1	6.3	-2.1	2.1	2.3	-2.4	2.3	-2.5	-0.8	-0.9	-0.2	0.7	0.0
Indifference point function log k	1.0	3.1	6.3	-2.1	2.1	2.3	-2.4	2.3	-2.5	-0.8	-0.9	-0.2	0.7	0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.9	0.0	-0.0	-0.2	-0.2	-0.5	0.7	0.6	0.2	-0.4	-0.4	-1.0
Patch foraging total patch changes 12 sec	0.8	1.0	2.5	1.1	-1.1	-1.1	0.7	-0.9	0.6	1.6	0.9	-0.8	-1.3	0.5
Patch foraging total patch changes 18 sec	1.1	2.6	3.9	1.6	-1.7	-1.9	1.4	-1.3	1.8	1.8	2.0	-1.3	-1.9	-0.2
Patch foraging total patch changes 24 sec	0.2	0.7	1.7	0.8	-0.8	-1.1	0.8	-1.1	1.2	0.3	0.4	0.1	-0.6	-1.3
Patch foraging total patch changes 6 sec	1.3	2.2	5.1	1.5	-1.5	-1.7	1.3	-1.8	2.3	1.6	1.3	-0.8	-1.3	-0.3
Patch foraging time to switch 0 sec	0.1	0.5	1.7	0.7	-0.7	-0.3	0.5	-0.1	-0.9	0.7	0.8	-0.4	-0.7	1.3
Patch foraging water rate 0 sec	0.2	0.7	4.0	-0.9	0.8	0.4	-0.8	0.1	0.9	0.1	0.1	-0.8	-0.1	-2.0
Patch foraging water rate 12 sec	0.1	0.6	1.2	-1.0	1.0	0.9	-1.1	0.2	-0.1	-0.7	-1.0	0.5	0.7	-0.7
Patch foraging water rate 18 sec	0.2	0.3	0.9	-0.8	0.8	0.5	-0.6	-0.1	0.9	0.0	-0.2	-0.5	-0.0	-1.0
Patch foraging water rate 24 sec	1.4	2.0	4.4	-2.0	1.9	1.8	-2.1	1.8	-1.1	0.0	-0.3	-0.8	0.2	-1.2
Patch foraging water rate 6 sec	1.0	1.5	2.7	-1.4	1.4	1.1	-1.3	0.9	-0.0	-1.2	-1.6	0.8	1.2	-1.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.1	-0.1	0.1	0.2	0.5	-0.2	0.5	-0.9	-0.5	0.9	1.0	0.3
Distance traveled before self-admin	0.9	1.9	3.7	1.9	-1.9	-1.6	1.9	-1.8	0.9	1.1	0.8	0.0	-0.7	1.0
Distance traveled after self-admin	1.0	1.8	4.4	1.1	-1.2	-1.2	0.9	-0.4	1.4	2.1	1.5	-1.7	-1.7	-0.3
Extensor digitorum longus weight	0.3	1.2	3.2	0.8	-0.8	-0.6	0.9	-1.6	1.2	-1.0	-0.8	1.8	1.1	0.8
Bone: elastic displacement	0.2	0.2	0.4	-0.7	0.6	0.7	-0.5	0.4	-0.3	0.1	-0.4	-0.6	-0.1	0.1
Bone: elastic work	1.1	1.4	4.5	0.1	-0.2	0.1	-0.3	0.1	-0.8	1.9	1.3	-2.1	-1.7	1.3
Bone: endosteal estimation	0.6	1.4	4.4	0.1	-0.2	0.1	-0.2	1.0	-0.6	1.8	1.3	-2.1	-1.7	1.2
Bone: endosteal perimeter	0.5	1.3	3.1	-0.4	0.3	0.6	-0.6	1.3	-1.5	1.1	0.9	-1.8	-1.2	1.8
Epididymis fat weight	1.0	5.3	13.7	-2.5	2.4	2.5	-3.3	3.3	-3.7	0.1	0.6	-1.6	-0.2	-1.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.5	1.1	-1.1	-1.2	0.6	-1.2	0.4	0.7	0.8	-0.0	-0.6	0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.2	0.1	-0.1	-0.0	0.3	-0.2	0.5	-0.0	-0.1	0.0	-0.0	0.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.9	0.1	-0.1	-0.2	0.0	0.5	0.3	0.9	0.9	-0.9	-0.8	-0.3
Delay discount exponential model param	2.1	2.9	5.6	-2.3	2.2	2.2	-2.4	2.3	-1.8	-0.7	-0.4	-0.7	0.5	-0.8
Extinction: sum of active levers before priming	1.0	1.5	3.9	1.6	-1.6	-1.3	1.3	-0.4	-0.1	1.1	1.3	-0.3	-1.1	2.0
Active lever presses in extinction session 6	0.2	0.2	0.8	0.3	-0.3	-0.1	0.1	0.3	-0.4	0.4	0.7	-0.3	-0.6	0.9
Bone: final force	1.1	1.8	4.4	1.0	-1.1	-0.9	0.4	-0.5	-0.1	2.1	1.7	-1.7	-1.8	1.7
Bone: final moment	1.2	1.9	4.8	1.0	-1.1	-0.9	0.4	-0.5	-0.0	2.2	1.8	-1.9	-1.9	1.6
Food consumed during 24 hour testing period	0.5	0.9	2.1	0.8	-0.9	-0.7	-0.1	-0.2	-0.3	1.2	1.5	-1.2	-1.4	1.1
Glucose	0.3	0.4	1.8	-0.1	0.0	-0.0	-0.3	0.8	-0.6	0.5	0.6	-0.8	-0.7	-1.3
Heart weight	1.2	1.9	6.0	-1.1	1.0	1.1	-1.4	1.6	-1.1	1.2	1.6	-2.5	-1.2	0.4
Delay discount hyperbolic model param	2.3	3.0	5.9	-2.4	2.3	2.2	-2.4	2.4	-1.7	-0.6	-0.3	-0.9	0.5	-0.9
Intermittent access intake day 1-15 change	0.0	0.2	0.5	-0.2	0.3	0.2	-0.4	0.2	0.4	-0.6	-0.4	0.6	0.7	-0.2
Intermittent access intake escalation	0.1	0.3	0.9	-0.3	0.4	0.3	-0.3	0.1	0.5	-0.9	-0.7	0.8	1.0	-0.3
Intermittent access intake escalation 2	0.2	0.3	0.8	-0.5	0.5	0.3	-0.5	-0.0	0.4	-0.9	-0.5	0.6	0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.1	1.4	3.8	0.5	-0.6	-0.6	0.6	0.5	0.1	1.8	1.4	-1.9	-2.0	-1.0
Intermitt. access day 15 inactive lever presses	0.2	1.1	2.4	1.1	-1.1	-1.3	1.2	-0.4	1.5	0.9	1.0	-0.8	-1.0	-0.7
Intermitt. access escalation Index	0.1	0.4	1.9	0.0	0.0	0.0	0.0	0.3	0.2	-1.0	-0.8	1.4	1.1	0.2
Intermittent access day 1 total infusions	1.7	5.0	8.9	3.0	-3.0	-2.8	2.5	-1.9	1.4	2.1	2.1	-0.9	-2.1	1.7
Intermittent access day 15 total infusions	0.9	2.2	4.2	2.0	-2.0	-2.0	1.8	-1.7	1.7	0.7	0.7	0.3	-0.7	1.1
Intermittent access terminal intake (last 3 days)	1.3	2.3	4.3	2.1	-2.0	-2.0	2.0	-1.7	1.6	0.8	1.0	0.1	-0.8	1.2
Intermittent access total infusions	5.2	6.1	11.1	3.3	-3.3	-3.2	2.9	-2.5	2.0	2.0	2.2	-0.6	-2.0	1.6
Intermittent access day 1 locomotion	1.6	3.0	5.2	2.3	-2.3	-2.2	1.9	-1.5	1.4	1.7	1.9	-0.7	-1.5	0.6
Intermittent access day 15 total locomotion	0.4	1.5	3.4	1.5	-1.6	-1.6	1.1	-0.7	0.7	1.2	1.8	-0.9	-1.3	0.3
Intermittent access total locomotion	2.0	2.5	5.5	1.7	-1.8	-1.9	1.1	-0.8	1.1	1.7	2.4	-1.4	-1.8	-0.2
Intermittent access standard deviation	0.6	3.2	7.5	1.9	-2.0	-1.8	1.2	-1.0	0.7	2.7	1.9	-2.0	-2.4	0.2
Left kidney weight	1.3	10.8	27.8	-2.4	2.2	2.7	-3.6	4.0	-5.3	2.6	2.6	-4.7	-2.7	1.0
Right kidney weight	2.1	14.5	31.7	-3.1	2.8	3.1	-4.4	4.9	-5.6	2.9	3.1	-5.6	-3.0	-0.0
Cocaine induced anxiety	0.2	0.4	1.1	-0.5	0.5	0.5	-0.9	0.9	-1.1	-0.2	0.9	-0.6	-0.2	0.1
Post-drug Anxiety	1.1	1.3	2.5	-1.6	1.6	1.4	-1.5	1.3	-0.7	-1.1	-0.3	-0.0	0.8	-0.9
Baseline Anxiety	0.3	0.4	1.2	-0.1	0.1	-0.1	0.3	-0.7	1.1	-0.7	-1.0	0.8	0.7	-0.4
Tail length	0.4	2.1	5.7	-2.0	1.9	1.5	-1.7	1.4	0.2	-0.9	-0.9	-0.3	0.8	-2.4
Length with tail	1.0	4.3	9.7	-2.8	2.7	2.5	-3.1	2.7	-1.5	-0.1	-0.3	-1.5	0.1	-1.9
Length without tail	0.7	3.6	8.2	-1.6	1.5	1.5	-2.4	2.5	-2.1	1.6	1.8	-2.9	-1.5	-0.2
Times rat made contact with spout	0.3	0.3	1.8	0.1	-0.2	-0.6	-0.1	-0.5	1.0	-0.1	0.1	0.0	0.0	-1.4
Lifetime Intake	6.0	7.5	13.3	3.6	-3.6	-3.5	3.1	-2.7	1.7	2.5	2.7	-1.0	-2.5	1.8
Liver weight, left	0.7	1.3	2.5	-1.3	1.3	1.3	-1.4	1.1	-1.6	-1.1	-0.9	0.5	0.9	-0.5
Liver weight, right	5.1	8.8	14.6	-3.7	3.7	3.7	-3.8	3.8	-3.5	-2.2	-1.6	0.4	2.2	-1.5
Locomotor activity	0.6	1.0	3.8	-1.1	1.0	1.1	-1.9	1.1	-1.2	0.3	0.4	-0.9	-0.3	0.4
Locomotor testing distance	0.1	0.2	0.7	-0.3	0.3	0.2	-0.8	-0.1	0.3	-0.5	-0.4	0.5	0.5	-0.2
Locomotor testing rearing	0.1	0.5	1.3	-0.3	0.3	0.4	-1.1	0.5	-1.2	0.4	0.6	-0.7	-0.5	0.8
Locomotion in novel chamber	1.6	2.1	5.5	-0.9	1.0	0.9	-0.5	0.3	0.4	-2.2	-2.1	2.4	2.3	-0.6
Locomotion in novel chamber post-restriction	0.3	0.8	2.9	0.6	-0.5	-0.5	0.8	-0.6	0.2	-1.1	-1.0	1.7	1.0	0.6
Fecal boli incidents, locomotor time 1	0.8	2.0	3.2	1.3	-1.4	-1.5	1.2	-1.3	1.8	1.6	1.6	-1.5	-1.6	-0.0
Change in fecal boli incidents, locomotor task	1.2	1.2	2.9	-1.5	1.5	1.3	-1.7	1.2	-0.8	-0.8	-0.9	0.2	1.0	0.1
Time >=10cm from walls, locomotor time 1	0.6	0.8	2.6	0.1	-0.2	-0.1	-0.2	0.5	-0.4	1.4	1.3	-1.6	-1.3	0.5
Bouts of movement, locomotor time 1	0.2	0.2	1.0	-0.4	0.4	0.3	-0.5	1.0	-0.8	0.0	0.2	-0.4	-0.2	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.1	-0.1	-0.1	-0.0	0.5	-0.3	0.5	0.7	-0.8	-0.7	0.1
Rest time, locomotor task time 1	0.5	0.7	2.2	0.3	-0.4	-0.4	0.3	0.4	-0.2	1.2	1.4	-1.5	-1.4	-0.4
Distance moved, locomotor task time 1	0.4	1.2	1.9	-1.2	1.3	1.4	-1.3	0.9	-1.2	-1.0	-1.1	0.7	1.1	0.0
Vertical activity count, locomotor time 1	0.2	1.2	3.7	-1.4	1.3	1.1	-1.6	1.1	-0.3	-0.5	-0.4	-0.2	0.6	-1.9
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.1	-0.6	0.5	0.4	-0.1	0.8	0.3	0.5	0.4	-1.0	-0.3	0.1
Bouts of movement, locomotor time 2	0.2	0.5	1.5	0.6	-0.6	-0.3	0.2	-0.0	-1.1	-0.7	-0.3	1.2	0.6	1.0
Total resting periods, locomotor time 2	0.2	0.6	1.4	1.1	-1.1	-0.8	0.7	-0.5	-0.7	-0.4	0.0	1.0	0.2	1.2
Rest time, locomotor task time 2	0.4	0.6	1.1	0.9	-0.9	-1.0	0.8	-0.6	0.8	0.9	0.6	-0.5	-0.9	0.2
Distance moved, locomotor task time 2	0.8	1.1	2.1	-1.4	1.4	1.5	-1.1	1.2	-1.2	-0.4	-0.7	-0.1	0.5	-0.5
Vertical activity count, locomotor time 2	0.3	0.7	1.9	-1.1	1.1	0.9	-1.1	1.4	-0.5	0.1	0.1	-0.8	0.1	-1.0
Light reinforcement 1	0.0	0.2	0.4	0.4	-0.4	-0.3	0.4	-0.5	0.5	-0.1	0.4	-0.2	-0.4	0.7
Light reinforcement 2	0.5	1.1	3.9	-0.8	0.8	1.1	-0.7	1.1	-2.0	-0.9	-0.6	0.5	1.0	1.2
Bone: marrow area	0.6	1.5	4.8	0.1	-0.2	0.1	-0.3	1.0	-0.6	1.9	1.4	-2.2	-1.8	1.1
Bone: maximum diameter	1.0	2.1	6.4	0.0	-0.1	0.2	-0.6	0.7	-1.2	1.8	2.0	-2.5	-2.1	1.6
Bone: maximum force	1.6	3.2	7.2	1.4	-1.5	-1.3	0.6	-0.7	0.2	2.7	2.6	-2.3	-2.4	1.8
Bone: maximum moment	1.8	3.3	7.5	1.4	-1.5	-1.3	0.5	-0.7	0.2	2.7	2.7	-2.4	-2.5	1.7
Mean time between licks in bursts	0.1	0.7	2.2	0.5	-0.4	-0.1	1.0	-1.3	0.6	-0.5	-0.6	1.1	0.5	1.5
Mean num. licks in bursts	0.2	0.6	1.4	-0.8	0.7	0.6	-1.2	1.0	-1.0	0.3	0.1	-0.6	-0.2	-0.9
Cd content in liver	0.3	0.3	1.4	-0.5	0.5	0.4	-1.2	0.6	-0.0	-0.6	-0.2	0.3	0.2	0.8
Co content in liver	0.9	1.0	2.7	1.2	-1.2	-1.3	0.7	-1.3	1.6	0.6	0.9	-0.1	-0.7	0.4
Cu content in liver	1.7	2.0	5.7	1.2	-1.1	-1.3	1.8	-1.8	2.4	-1.0	-0.3	1.9	1.0	-0.0
Fe content in liver	1.4	1.7	4.6	-1.1	1.0	1.2	-1.4	1.8	-0.8	1.2	1.3	-2.2	-1.2	0.6
K content in liver	0.1	0.1	0.4	0.1	-0.1	-0.2	0.5	-0.4	0.4	-0.1	-0.6	0.4	0.4	-0.3
Mg content in liver	0.1	0.1	0.4	0.4	-0.4	-0.4	0.7	-0.2	0.4	0.2	0.2	-0.0	0.1	-0.1
Mn content in liver	0.3	0.3	1.0	-0.1	0.1	0.1	0.2	0.2	-0.7	-0.6	-1.0	1.0	0.9	0.2
Na content in liver	0.1	0.1	0.7	-0.2	0.2	0.1	0.1	-0.0	0.8	-0.2	0.2	0.0	0.4	-0.7
Rb content in liver	0.9	1.0	2.0	1.1	-1.2	-1.2	1.2	-1.2	0.8	0.8	1.4	-0.6	-0.9	0.2
Se content in liver	1.4	1.6	3.8	-1.1	1.1	1.1	-1.0	0.3	-0.2	-1.7	-1.6	1.8	2.0	0.3
Sr content in liver	1.7	1.5	4.9	0.4	-0.3	-0.5	0.8	-1.0	1.1	-1.5	-1.3	2.2	1.6	-1.2
Zn content in liver	0.1	0.1	0.3	-0.2	0.2	0.0	-0.4	-0.0	0.4	-0.4	-0.5	0.4	0.6	-0.6
Bone: minimum diameter	0.5	0.9	2.5	0.6	-0.7	-0.5	0.3	0.0	-0.5	1.4	1.2	-1.3	-1.6	0.8
Time in familiar zone, hab. session 1	0.4	0.4	0.8	0.6	-0.6	-0.7	0.7	-0.5	0.9	0.4	0.7	-0.4	-0.8	0.9
Time in novel zone, hab. session 1	0.7	0.8	2.1	-1.0	0.9	1.1	-1.4	1.2	-1.3	-0.2	0.0	-0.3	0.5	-0.0
Total zone transitions, hab. session 1	1.4	1.9	5.9	0.0	0.1	-0.1	0.5	-1.0	1.5	-1.9	-2.2	2.4	1.7	0.0
Total locomotion distance, hab. session 1	0.9	1.3	4.2	-0.7	0.7	0.5	-0.5	0.1	0.7	-1.7	-2.1	1.8	1.4	-0.4
Locomotion velocity, hab. session 1	0.7	1.0	3.3	-0.2	0.3	0.0	0.1	-0.2	1.1	-1.4	-1.8	1.7	1.1	-0.4
Time in familiar zone, hab. session 2	1.0	1.1	2.7	-0.9	1.0	0.9	-0.5	0.4	-0.4	-1.5	-1.7	1.4	1.5	0.3
Time in novel zone, hab. session 2	1.0	1.1	2.6	1.0	-1.1	-1.1	0.3	-0.3	0.4	1.6	1.6	-1.2	-1.5	-0.5
Total zone transitions, hab. session 2	1.3	1.7	5.2	1.4	-1.4	-1.6	1.6	-1.6	2.3	0.6	0.8	-0.2	-0.9	0.1
Total locomotion distance, hab. session 2	1.3	1.7	3.5	1.6	-1.6	-1.6	1.5	-1.5	1.9	1.0	0.7	-0.4	-1.2	0.7
Locomotion velocity, hab. session 2	1.6	2.1	4.8	1.7	-1.7	-1.8	1.8	-1.7	2.2	1.0	0.7	-0.4	-1.2	0.4
Novel to familiar place preference ratio	1.5	2.0	5.6	-1.8	1.7	1.7	-2.4	2.1	-1.2	-0.8	-0.1	-0.2	0.6	-0.4
Novelty place preference	2.2	2.8	7.4	-2.1	2.1	2.0	-2.7	2.4	-1.5	-1.0	-0.4	-0.1	0.9	-0.3
Time in novel zone, NPP test	2.6	3.2	8.6	-2.3	2.3	2.2	-2.9	2.6	-1.6	-1.1	-0.3	-0.1	1.0	-0.5
Total zone transitions, NPP test	1.1	1.6	5.4	0.9	-0.8	-1.1	1.3	-1.6	2.3	-0.8	-1.2	1.6	0.7	0.2
Total locomotion distance, NPP test	0.6	0.8	3.1	0.9	-0.8	-1.0	1.1	-1.1	1.8	0.2	-0.4	0.3	-0.4	0.2
Locomotion velocity, NPP test	0.8	1.1	3.1	1.1	-1.0	-1.1	1.4	-1.5	1.8	0.0	-0.7	0.7	-0.1	0.4
Intraocular pressure	0.2	0.3	0.9	-0.3	0.3	0.4	-0.6	0.8	-1.0	0.3	0.1	-0.6	-0.6	0.1
Delta distance traveled before/after self-admin	1.3	1.4	3.3	-1.2	1.1	0.8	-1.5	1.7	-0.1	0.9	0.7	-1.8	-0.8	-1.3
Delta ambulatory time before/after self-admin	0.7	1.1	3.9	-0.8	0.7	0.5	-1.2	1.1	0.2	1.2	1.0	-2.0	-1.1	-0.9
Parametrial fat weight	1.4	3.3	5.7	-2.4	2.4	2.1	-2.1	1.9	-1.1	-1.7	-1.7	0.5	1.7	-1.8
Pavlov. Cond. lever latency	0.0	0.1	0.4	-0.2	0.2	0.2	-0.3	-0.1	-0.2	-0.0	0.6	-0.2	0.0	-0.0
Pavlov. Cond. magazine entry latency	1.1	1.4	3.0	1.6	-1.6	-1.5	1.7	-1.3	1.1	0.6	0.1	0.4	-0.6	1.0
Pavlov. Cond. change in total contacts	2.3	2.4	4.9	2.1	-2.1	-2.0	2.2	-1.9	1.6	0.9	0.6	0.3	-0.9	0.9
Pavlov. Cond. index score	0.6	0.8	1.5	1.2	-1.2	-1.1	1.2	-0.7	0.8	0.8	0.2	-0.2	-0.8	0.6
Pavlov. Cond. latency score	0.3	0.4	0.7	0.8	-0.8	-0.8	0.8	-0.4	0.6	0.5	-0.1	-0.1	-0.6	0.4
Pavlov. Cond. lever contacts	0.3	0.3	1.0	0.7	-0.7	-0.7	1.0	-0.5	0.8	0.3	-0.5	0.3	-0.3	-0.1
Pavlov. Cond. magazine entry number	1.1	1.4	3.4	-1.6	1.6	1.6	-1.8	1.5	-1.3	-0.4	-0.1	-0.4	0.5	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.5	-0.1	0.1	-0.2	0.0	-0.7	1.5	0.1	0.4	-0.2	-0.3	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.5	1.1	-1.1	-1.1	1.2	-0.7	0.8	0.5	-0.1	0.1	-0.6	0.5
Pavlov. Cond. response bias	0.9	1.1	2.8	1.4	-1.4	-1.4	1.7	-1.2	0.9	0.5	0.0	0.2	-0.6	0.5
Pavlov. Cond. lever latency	0.2	0.3	1.7	-0.1	0.1	0.1	-0.3	-0.1	-0.4	-0.8	-0.4	0.6	0.4	1.3
Pavlov. Cond. magazine entry latency	1.5	2.1	4.0	1.6	-1.6	-1.7	1.5	-1.8	2.0	1.2	1.0	-0.3	-1.0	-1.3
Pavlov. Cond. change in total contacts	1.1	2.6	7.6	0.7	-0.9	-0.8	0.5	-0.2	0.8	2.7	2.1	-2.8	-2.4	-0.8
Pavlov. Cond. index score	0.7	1.1	2.5	0.8	-0.8	-0.9	0.8	-0.9	1.4	1.3	0.8	-0.9	-0.9	-1.6
Pavlov. Cond. latency score	0.8	1.3	3.0	0.9	-0.9	-1.1	1.0	-1.1	1.6	1.3	0.8	-0.8	-0.9	-1.7
Pavlov. Cond. lever contacts	0.2	0.3	1.9	-0.0	-0.0	-0.0	0.1	0.1	0.5	0.7	0.4	-0.6	-0.3	-1.4
Pavlov. Cond. magazine entry number	0.6	0.7	2.5	-0.6	0.6	0.7	-0.7	0.9	-1.2	-0.9	-0.3	0.5	0.6	1.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.9	0.4	-0.4	-0.5	0.4	0.4	-0.3	0.7	0.9	-0.8	-0.9	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.2	0.7	-0.7	-0.8	0.7	-0.9	1.3	1.3	0.6	-0.7	-0.8	-1.5
Pavlov. Cond. response bias	0.5	0.7	1.8	0.7	-0.8	-0.7	0.8	-0.5	0.9	1.3	0.8	-0.8	-0.9	-1.0
Time in closed arm before self-admin	0.2	0.4	1.9	0.5	-0.5	-0.5	0.7	-0.7	1.4	-0.1	-0.0	0.2	0.0	-0.7
Time in closed arm after self-admin	0.3	0.3	1.4	0.1	-0.2	-0.4	-0.2	-0.1	0.2	0.5	0.9	-0.7	-0.6	-1.2
Time in open arm before self-admin	0.3	0.4	0.9	-0.8	0.8	0.7	-0.4	0.3	-0.3	-0.6	-0.9	0.4	0.8	-0.5
Time in open arm after self-admin	0.6	0.7	1.8	-0.7	0.7	0.7	-0.2	0.2	-0.0	-1.1	-1.3	1.2	1.3	-0.0
Bone: periosteal estimation	0.7	1.6	4.3	0.4	-0.5	-0.2	-0.1	0.4	-0.8	1.9	1.6	-2.1	-1.9	1.5
Bone: periosteal perimeter	1.0	2.0	5.3	-0.4	0.3	0.6	-0.9	1.1	-1.7	1.6	1.4	-2.3	-1.7	1.8
Bone: post-yield work	1.4	2.4	6.0	1.7	-1.7	-1.7	1.1	-1.0	1.5	1.3	2.4	-1.2	-1.4	1.4
Progressive ratio test 1 active lever presses	2.7	4.8	8.4	2.9	-2.9	-2.8	2.6	-2.0	1.5	2.2	2.0	-0.7	-1.8	1.5
Progressive ratio test 1 breakpoint	2.5	4.3	7.6	2.8	-2.8	-2.7	2.5	-2.0	1.5	2.0	1.9	-0.6	-1.7	1.4
Progressive ratio test 1 inactive lever presses	2.4	6.3	10.5	3.2	-3.2	-3.0	3.0	-2.3	1.6	2.6	2.5	-1.2	-2.7	0.9
Progressive ratio test 2 active lever presses	2.9	4.0	8.2	2.8	-2.8	-2.9	2.5	-1.9	1.4	1.7	1.6	-0.4	-1.7	0.7
Progressive ratio test 2 breakpoint	3.3	4.2	8.4	2.9	-2.9	-2.9	2.6	-2.1	1.4	1.6	1.5	-0.3	-1.6	1.0
Progressive ratio test 2 inactive lever presses	0.9	2.9	6.2	2.4	-2.4	-2.5	2.4	-1.8	1.8	0.7	0.8	0.5	-0.7	0.1
Incentive Sensitization - Responses	0.1	0.4	1.0	0.9	-0.9	-1.0	0.9	-0.7	0.4	0.0	-0.2	0.5	-0.3	-0.1
Incentive Sensitization - Breakpoint	0.2	0.4	1.1	0.9	-0.9	-1.1	0.9	-0.6	0.3	0.1	-0.0	0.3	-0.4	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	1.0	-0.2	0.2	0.2	-0.3	1.0	-0.1	-0.1	0.1	-0.1	-0.2	0.1
Progressive ratio	0.1	0.3	1.0	0.5	-0.5	-0.5	0.3	-0.4	0.8	0.7	1.0	-0.6	-0.5	-0.2
Food seeking constrained by brief footshock	0.4	0.5	1.8	0.8	-0.8	-0.7	0.2	-0.7	-0.3	0.5	0.9	-0.2	-0.3	1.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.8	0.4	-0.4	-0.3	0.2	-0.3	-0.7	0.2	0.2	-0.0	-0.4	0.9
Retroperitoneal fat weight	1.6	7.4	21.6	-3.0	2.9	3.1	-3.8	3.7	-4.6	0.1	0.5	-2.0	-0.2	-0.0
Reaction time number correct	0.5	1.6	5.6	-0.7	0.8	0.7	-0.1	0.6	-0.6	-1.5	-2.4	2.0	1.8	0.5
Reaction time mean minus median	0.0	0.0	0.1	-0.0	-0.0	0.1	0.1	0.3	0.1	0.2	-0.1	-0.2	-0.2	-0.2
Reaction time mean minus median AUC	0.1	0.4	1.0	-0.6	0.6	0.6	-0.6	1.0	-0.9	-0.1	-0.2	-0.4	-0.1	-0.7
Reaction time num false alarms	0.1	0.2	0.7	-0.6	0.6	0.6	-0.8	0.3	-0.1	-0.4	-0.5	0.3	0.5	0.0
Reaction time num false alarms AUC	0.1	0.3	0.7	-0.6	0.6	0.6	-0.8	0.2	0.0	-0.6	-0.7	0.5	0.7	0.0
Reaction time trials correct on left	0.5	1.6	5.6	-0.7	0.8	0.7	-0.1	0.6	-0.6	-1.5	-2.4	2.0	1.8	0.5
Reaction time trials on left	0.5	1.6	5.8	-0.6	0.7	0.7	-0.1	0.5	-0.5	-1.5	-2.4	2.1	1.9	0.5
Reaction time mean	0.1	0.2	0.6	-0.3	0.3	0.4	-0.1	0.7	-0.1	0.3	-0.0	-0.5	0.0	-0.8
Reaction time mean AUC	0.1	0.1	0.5	-0.3	0.3	0.3	-0.1	0.6	-0.1	0.1	-0.1	-0.3	0.1	-0.7
Median of all reaction times	0.1	0.1	0.4	-0.3	0.3	0.3	0.0	0.5	-0.1	0.3	-0.1	-0.4	0.1	-0.6
Reaction time omissions	0.7	1.1	2.6	1.4	-1.3	-1.1	1.3	-1.0	0.6	-0.0	-0.5	1.2	0.2	1.6
Reaction time false alarm rate	0.1	0.1	0.5	-0.3	0.3	0.3	-0.7	-0.0	0.1	-0.1	0.3	-0.3	-0.0	-0.3
Reaction time premature initiation rate	1.3	2.0	5.7	1.2	-1.3	-1.2	0.5	-0.3	0.8	2.0	1.7	-1.8	-2.4	0.4
Reaction time premature initiations	0.2	0.6	2.0	0.7	-0.8	-0.7	0.3	0.2	0.4	1.2	0.5	-0.8	-1.4	0.4
Std. dev. reaction times	0.1	0.3	1.1	-0.6	0.5	0.6	-0.6	1.1	-0.3	0.2	-0.1	-0.6	-0.1	-0.6
Reaction time trials completed	0.5	1.6	5.8	-0.6	0.7	0.7	-0.1	0.5	-0.5	-1.5	-2.4	2.1	1.9	0.5
Reaction time trials AUC	0.4	1.4	4.7	-0.7	0.8	0.7	-0.2	0.6	-0.7	-1.3	-2.2	1.8	1.7	0.5
Run reversals in cocaine runway, females	0.7	0.8	1.7	-1.2	1.2	1.0	-1.0	0.8	-0.2	-1.3	-0.9	0.3	0.4	-0.4
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.1	0.1	-0.1	0.1	-0.6	0.2	0.2	0.2	-0.5	-0.3	-0.4
Latency to leave start box in cocaine runway	0.4	0.6	2.9	-0.5	0.5	0.8	-0.1	0.7	-1.7	-0.3	-0.2	0.1	0.4	1.3
Latency to leave start box in cocaine runway, F	0.3	0.4	2.9	0.3	-0.2	0.1	0.7	-0.6	-0.6	0.0	-0.1	0.1	0.1	1.7
Latency to leave start box in cocaine runway, M	1.5	1.4	4.8	-1.2	1.2	1.4	-1.1	2.2	-2.1	-0.5	-0.4	0.1	0.6	-0.1
Std. dev. time between licks in bursts	0.2	0.4	1.6	0.4	-0.4	-0.4	0.7	-1.1	1.3	0.7	0.1	-0.3	-0.4	-0.4
Total sessions with >9 infusions	3.7	4.6	8.2	2.4	-2.4	-2.2	1.9	-1.5	0.0	2.9	2.9	-1.9	-2.5	1.6
Short access day 1 total inactive lever presses	2.8	5.6	10.7	2.0	-2.1	-2.1	1.6	-1.5	2.1	3.1	3.3	-3.0	-3.1	-0.2
Short access day 10 total inactive lever presses	0.2	1.2	5.1	-1.0	0.9	0.6	-0.7	1.4	-0.2	0.3	0.7	-1.6	-0.8	-2.2
Short access day 1 total infusions	1.3	2.5	4.5	1.6	-1.7	-1.6	1.6	-1.2	0.8	2.0	2.1	-1.7	-1.9	0.1
Short access day 10 total infusions	2.1	3.5	5.8	2.2	-2.2	-2.0	1.7	-1.2	0.3	2.4	2.3	-1.4	-2.2	1.6
Short access total infusions	4.3	6.1	9.4	3.0	-3.0	-2.8	2.5	-1.9	0.7	2.9	3.1	-1.8	-2.7	1.7
Short access day 1 locomotion	0.8	1.3	3.1	1.0	-1.1	-1.0	0.9	-0.8	0.6	1.8	1.3	-1.4	-1.3	-0.2
Short access day 10 total locomotion	0.5	2.0	4.7	1.4	-1.5	-1.5	1.2	-0.6	1.1	2.2	1.3	-1.3	-1.8	-1.4
Short access total locomotion	1.6	2.4	6.1	1.6	-1.7	-1.6	1.2	-1.0	0.4	2.5	1.9	-1.6	-1.9	-0.1
One hour access (0.3 mA shock)	4.2	4.9	9.8	3.1	-3.1	-3.0	3.0	-2.9	2.0	0.6	1.0	1.0	-0.7	1.3
Compulsive drug intake	0.3	0.4	1.4	0.2	-0.1	-0.5	0.6	-0.4	1.2	-0.8	-0.4	0.7	0.5	-1.1
One hour access (shock baseline)	0.7	2.0	4.0	2.0	-2.0	-1.7	1.7	-1.8	0.6	0.7	0.8	0.4	-0.7	1.6
Social response proportion	0.7	0.8	6.9	0.6	-0.6	-0.0	0.4	-0.3	-0.4	0.8	0.4	-0.4	-0.5	2.6
Social responses	0.8	1.1	2.3	1.2	-1.2	-1.1	0.9	-1.5	1.0	0.8	0.5	-0.2	-0.9	1.5
Social time	1.6	2.5	5.1	2.1	-2.1	-2.0	2.0	-2.3	1.8	1.0	0.2	0.4	-0.8	0.8
Soleus weight	0.5	1.4	3.9	0.9	-1.0	-1.5	0.5	-1.2	1.8	1.0	0.2	-0.7	-1.0	-2.0
Bone: stiffness	1.0	1.8	4.7	0.8	-0.9	-0.7	0.2	-0.2	-0.1	2.1	2.2	-2.1	-1.8	1.3
Tibialis anterior weight	1.1	3.8	9.5	2.4	-2.3	-2.3	2.2	-3.1	2.6	-0.3	-0.2	2.0	0.4	0.2
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	0.3	-0.3	-0.4	-0.1	0.4	0.5	0.4	0.6	-0.4	-0.6	0.2
Time to tail flick, vehicle, after self-admin	0.3	0.6	2.0	-1.0	1.0	0.7	-1.0	0.7	0.8	-0.0	-0.4	-0.5	0.1	-1.4
Time to tail flick, test, before self-admin	0.2	0.3	1.0	0.4	-0.4	-0.3	0.2	-1.0	-0.7	-0.6	-0.3	0.8	0.3	0.3
Time to tail flick, test, after self-admin	0.3	0.3	1.0	-0.4	0.5	0.3	-0.0	0.1	0.3	-0.6	-0.6	0.6	1.0	-0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.1	-0.1	-0.1	0.2	-0.5	0.4	0.7	0.4	-0.8	-0.5	-0.3
Delta time to tail flick, test, before/after SA	0.6	0.8	1.9	-0.7	0.7	0.5	-0.3	0.6	1.1	-1.0	-1.0	1.0	1.4	-1.1
Tibia length	0.3	0.7	2.1	0.3	-0.3	-0.3	-0.3	0.5	-0.4	1.3	0.9	-1.4	-1.4	0.8
Ambulatory time before self-admin	0.3	1.0	2.2	1.4	-1.4	-1.3	1.5	-1.4	1.0	0.6	0.1	0.5	-0.1	0.5
Ambulatory time after self-admin	0.5	0.8	3.2	0.6	-0.6	-0.8	0.5	-0.4	1.8	1.2	0.6	-0.9	-0.7	-0.3
Bone: tissue strength	0.2	0.2	0.5	-0.5	0.5	0.5	-0.7	0.6	-0.7	0.2	-0.0	-0.4	0.0	0.1
Total heroin consumption	0.9	1.1	2.1	1.5	-1.5	-1.4	0.9	-1.0	0.5	0.6	0.9	0.0	-0.7	1.3
Bone: trabecular number	0.2	0.5	1.0	-0.8	0.8	0.8	-0.6	0.6	-0.5	-0.7	-1.0	0.5	0.7	0.1
Bone: trabecular spacing	1.2	1.8	4.2	1.1	-1.2	-1.2	0.5	-0.3	0.4	1.9	2.0	-1.9	-1.9	0.5
Bone: trabecular thickness	0.6	0.9	1.9	-0.9	0.9	1.0	-0.3	0.6	-0.8	-1.2	-1.4	1.1	1.2	-0.5
Bone: trabecular tissue density	0.3	0.5	1.2	-0.8	0.8	0.7	-0.4	-0.2	0.7	-1.0	-0.3	0.6	1.0	-1.1
Water consumed over 24 hours	0.2	0.4	1.3	0.3	-0.4	-0.7	-0.2	-0.6	1.0	0.6	0.5	-0.5	-0.5	-1.1
Number of responses in last shaping day	4.5	5.9	11.0	3.3	-3.3	-3.0	3.1	-2.6	1.3	2.3	1.9	-0.6	-2.0	1.6