Hub : Genes

Dmc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_001130567.1 0.02 0.01 4.1e-03 0 0.01 0 0 5.6e-02 8.4e-03 5.2e-02 6.2e-02
2 NAcc isoform ratio XM_039079586.2 0.02 0.01 6.1e-03 0 0.01 0 0 6.7e-02 1.7e-02 1.1e-01 1.5e-01
3 NAcc alternative TSS XM_039079586.2 0.02 0.01 3.5e-03 0 0.01 0 0 1.5e-01 2.7e-02 2.6e-01 2.3e-01
4 BLA mRNA stability Dmc1 0.09 0.05 4.4e-03 0 0.04 0.05 0 2.5e-01 4.9e-03 1.2e-03 1.7e-01
5 NAcc alternative TSS NM_001130567.1 0.02 0.01 4.1e-03 0.01 0.01 0 0 2.0e-02 2.2e-02 2.5e-01 1.7e-01
6 PL isoform ratio XM_039079586.2 0.04 0.03 4.5e-03 0.02 0.01 0.01 0.02 1.3e-03 8.2e-03 4.6e-02 6.2e-03
7 NAcc gene expression Dmc1 0.11 0.04 3.2e-14 0.12 0.1 0.11 0.12 2.6e-17 3.7e-15 1.8e-16 4.5e-17
8 PL gene expression Dmc1 0.06 0.03 9.8e-06 0.07 0.04 0.04 0.05 7.7e-08 2.1e-05 1.0e-05 1.6e-06
9 BLA gene expression Dmc1 0.09 0.05 6.6e-04 0.03 0.06 0.05 0.05 1.2e-02 6.8e-04 1.5e-03 8.2e-04
10 IC gene expression Dmc1 0.28 0.11 6.3e-06 0.1 0.07 0.06 0.12 3.9e-05 5.9e-04 1.1e-03 9.5e-06
11 OFC alternative TSS XM_039079586.2 0.18 0.11 7.0e-03 0.02 -0.01 0.02 0.01 8.9e-02 7.1e-01 9.3e-02 1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.00.20.1-0.1-0.0-0.10.1-0.4-0.00.20.20.1-0.0
Area under the delay curve2.53.05.62.3-2.3-2.3-2.42.4-1.8-0.8-0.50.7-0.6-0.7
BMI with tail0.51.73.7-1.61.61.61.7-1.61.90.9-0.1-0.11.00.1
BMI without tail0.51.53.1-1.81.71.61.5-1.20.61.10.4-0.11.11.2
Body weight1.25.111.0-2.92.82.73.3-3.22.50.2-0.5-1.80.31.4
Weight adjusted by age0.40.61.3-1.11.11.00.8-0.60.10.60.80.00.5-0.4
Bone surface0.10.30.80.6-0.6-0.5-0.30.2-0.7-0.40.0-0.1-0.6-0.9
Bone volume0.00.00.10.1-0.1-0.1-0.1-0.0-0.1-0.00.30.2-0.0-0.2
Breakpoint value in progressive ratio session0.20.20.50.5-0.5-0.5-0.3-0.20.1-0.7-0.6-0.2-0.6-0.5
Number of licking bursts0.40.62.00.6-0.6-0.8-0.91.1-1.40.60.10.80.4-0.1
Context. condit. distance diff. score5.16.210.6-3.23.23.23.3-3.23.11.41.2-0.41.11.6
Locomotion velocity, session 11.01.02.00.7-0.8-0.8-0.51.0-1.2-1.1-1.4-1.3-1.3-0.5
Locomotion distance, session 12.93.77.42.4-2.3-2.4-2.52.5-2.7-0.2-0.20.9-0.5-1.5
Locomotion velocity, session 20.70.86.20.7-0.7-0.4-0.30.20.3-0.4-0.6-0.2-0.4-2.5
Locomotion distance, session 24.76.511.43.4-3.3-3.3-3.13.1-3.1-1.6-1.20.1-1.6-1.8
Locomotion velocity, session 32.52.84.9-2.12.12.11.9-1.51.31.62.20.71.50.1
Locomotion distance, session 31.81.96.4-0.70.80.60.1-0.1-0.42.22.52.21.90.2
Stereotopy head waving bouts, day 30.70.82.80.1-0.2-0.20.4-0.40.1-1.4-1.4-1.7-1.1-0.4
Stereotopy head waving duration, day 31.51.85.9-0.70.60.81.2-1.31.2-1.5-1.9-2.4-1.3-0.6
Locomotion velocity, session 70.40.41.8-0.80.80.80.4-0.71.30.30.4-0.30.1-0.0
Locomotion distance, session 70.40.62.10.2-0.3-0.5-0.60.2-0.3-0.8-0.6-1.0-1.11.5
Stereotopy head waving bouts, day 73.33.76.9-2.42.42.62.1-2.42.51.30.8-0.11.4-1.3
Stereotopy head waving duration, day 73.33.97.9-2.32.32.72.0-2.32.81.50.80.21.6-1.4
Locomotion velocity, session 80.70.82.3-0.60.60.71.1-1.40.9-0.8-0.6-1.5-0.8-0.2
Locomotion distance, session 80.50.71.3-1.01.01.10.9-1.01.00.61.00.10.40.0
Degree of sensitization distance2.72.88.90.0-0.2-0.00.1-0.50.9-2.5-2.5-3.0-2.41.5
Degree of sensitization stereotypy2.93.15.8-2.12.12.41.7-2.02.31.40.90.31.5-1.7
Conditioned locomotion0.30.30.7-0.70.60.60.7-0.80.6-0.4-0.0-0.8-0.2-0.4
Cocaine response after cond. corrected0.70.81.80.7-0.8-0.6-0.40.5-0.2-1.2-1.2-1.1-1.2-1.3
Cocaine response after cond. not corrected0.40.41.70.6-0.6-0.4-0.20.30.1-0.9-0.5-0.6-0.9-1.3
Cocaine response before conditioning0.60.72.4-0.40.40.40.4-0.20.41.11.61.31.20.3
Saline control response0.81.12.3-1.31.31.31.5-0.60.90.51.50.40.60.5
Bone: connectivity density0.10.10.3-0.20.10.10.3-0.4-0.2-0.4-0.0-0.5-0.50.1
Bone: cortical apparent density1.52.04.5-1.51.61.31.1-0.20.12.11.61.61.90.9
Bone: cortical area0.60.81.70.6-0.7-0.5-0.10.50.4-1.3-1.3-1.2-1.3-1.1
Bone: cortical porosity0.50.61.90.4-0.4-0.00.1-0.51.4-1.0-0.1-1.0-1.1-0.7
Bone: cortical porosity1.21.33.30.5-0.5-0.10.2-0.61.6-1.7-0.9-1.8-1.7-1.0
Bone: cortical thickness0.50.82.41.2-1.2-1.2-0.71.5-0.3-0.6-0.40.1-0.7-0.6
Bone: cortical thickness1.72.04.21.9-1.9-2.0-1.32.1-1.2-0.9-1.1-0.1-1.1-0.6
Bone: cortical tissue density1.31.84.0-1.51.51.21.1-0.20.12.01.51.51.80.9
Condit. Reinf. active minus inactive responses0.10.21.1-0.10.1-0.20.10.3-0.60.0-0.10.1-0.21.1
Condit. Reinf. active-inactive response ratio0.40.51.3-0.90.90.70.8-0.30.50.60.40.30.31.1
Condit. Reinf. active responses0.50.63.8-0.40.40.10.10.2-0.90.70.60.80.51.9
Condit. Reinf. inactive responses0.81.04.5-0.50.50.3-0.00.0-0.81.11.21.11.12.1
Incentive salience index mean0.20.32.0-0.10.1-0.2-0.10.3-0.90.20.20.2-0.01.4
Condit. Reinf. lever presses0.20.32.4-0.20.2-0.1-0.00.0-0.70.40.60.30.31.5
Condit. Reinf. active minus inactive responses1.51.92.91.6-1.6-1.7-1.21.3-1.2-1.5-1.6-0.8-1.70.4
Condit. Reinf. active-inactive response ratio1.21.43.71.1-1.1-1.1-0.60.7-0.7-1.4-1.9-1.2-1.70.0
Condit. Reinf. active responses1.11.52.71.4-1.5-1.4-1.01.0-0.5-1.6-1.4-0.9-1.6-0.2
Condit. Reinf. inactive responses0.30.40.80.9-0.9-0.9-0.90.60.1-0.7-0.2-0.1-0.6-0.6
Condit. Reinf. lever presses0.40.51.40.8-0.8-0.8-0.80.4-0.9-0.7-0.30.1-0.31.2
Condit. Reinf. lever reinforcers received1.11.63.21.4-1.4-1.4-1.00.9-0.5-1.8-1.5-1.1-1.7-0.1
Conditioned reinforcement - actives1.52.65.52.3-2.3-2.4-1.81.9-1.3-1.3-1.00.0-1.0-0.9
Conditioned reinforcement - inactives3.24.79.42.8-2.8-3.1-2.32.1-2.7-1.5-1.9-0.3-1.60.2
Conditioned locomotion2.63.35.52.3-2.4-2.2-1.21.8-0.8-2.1-2.1-1.2-1.9-1.3
Patch foraging indifference point 0 sec0.20.31.0-0.20.20.00.40.1-0.5-0.9-0.5-0.8-0.71.0
Patch foraging indifference point AUC1.52.25.71.7-1.7-2.0-2.12.0-2.4-0.6-0.50.2-0.40.1
Delay disc. indifference point, 0s delay0.40.41.10.6-0.6-0.50.20.20.4-1.1-0.8-0.6-1.0-0.2
Delay disc. indifference point, 16s delay2.93.27.12.4-2.3-2.3-2.72.5-2.0-0.7-0.20.8-0.5-1.0
Delay disc. indifference point, 2s delay3.84.28.93.0-2.9-2.6-2.52.7-1.0-0.7-0.61.2-0.6-2.3
Delay disc. indifference point, 24s delay0.91.03.10.9-1.0-1.2-1.31.0-1.8-0.6-0.5-0.4-0.5-0.7
Delay disc. indifference point, 4s delay1.61.73.31.8-1.7-1.6-1.61.8-1.3-0.7-0.60.3-0.8-0.8
Delay disc. indifference point, 8s delay1.72.04.11.7-1.7-1.9-1.92.0-2.0-0.4-0.20.6-0.30.6
Indifference point function ln k1.73.16.3-2.12.12.32.4-2.32.50.80.9-0.20.7-0.0
Indifference point function log k1.73.16.3-2.12.12.32.4-2.32.50.80.9-0.20.7-0.0
Patch foraging total patch changes 0 sec0.10.20.90.0-0.0-0.20.20.5-0.7-0.6-0.2-0.4-0.41.0
Patch foraging total patch changes 12 sec0.81.02.51.1-1.1-1.1-0.70.9-0.6-1.6-0.9-0.8-1.3-0.5
Patch foraging total patch changes 18 sec1.72.63.91.6-1.7-1.9-1.41.3-1.8-1.8-2.0-1.3-1.90.2
Patch foraging total patch changes 24 sec0.40.71.70.8-0.8-1.1-0.81.1-1.2-0.3-0.40.1-0.61.3
Patch foraging total patch changes 6 sec1.42.25.11.5-1.5-1.7-1.21.8-2.3-1.6-1.3-0.8-1.30.3
Patch foraging time to switch 0 sec0.20.51.70.7-0.7-0.3-0.50.10.9-0.7-0.8-0.4-0.7-1.3
Patch foraging water rate 0 sec0.30.74.0-0.90.80.40.8-0.1-0.9-0.1-0.1-0.8-0.12.0
Patch foraging water rate 12 sec0.30.61.2-1.01.00.91.1-0.20.10.71.00.50.70.7
Patch foraging water rate 18 sec0.20.30.9-0.80.80.50.60.1-0.9-0.00.2-0.5-0.01.0
Patch foraging water rate 24 sec1.42.04.4-2.01.91.82.1-1.81.1-0.00.3-0.80.21.2
Patch foraging water rate 6 sec1.01.52.7-1.41.41.11.3-0.90.01.21.60.81.21.6
Seeking ratio, delayed vs. immediate footshock0.30.31.1-0.10.10.2-0.50.2-0.50.90.50.91.0-0.3
Distance traveled before self-admin1.41.93.71.9-1.9-1.6-1.91.8-0.9-1.1-0.80.0-0.7-1.0
Distance traveled after self-admin1.51.84.41.1-1.2-1.2-0.90.4-1.4-2.1-1.5-1.7-1.70.3
Extensor digitorum longus weight0.31.23.20.8-0.8-0.6-0.81.6-1.21.00.81.81.1-0.8
Bone: elastic displacement0.20.20.4-0.70.60.70.5-0.40.3-0.10.4-0.6-0.1-0.1
Bone: elastic work1.11.44.50.1-0.20.10.3-0.10.8-1.9-1.3-2.1-1.7-1.3
Bone: endosteal estimation0.61.44.40.1-0.20.10.2-1.00.6-1.8-1.3-2.1-1.7-1.2
Bone: endosteal perimeter0.61.33.1-0.40.30.60.5-1.31.5-1.1-0.9-1.8-1.2-1.8
Epididymis fat weight1.55.313.7-2.52.42.53.3-3.33.7-0.1-0.6-1.6-0.21.0
Delta time in closed arm before/after self-admin0.70.71.51.1-1.1-1.2-0.61.2-0.4-0.7-0.8-0.0-0.6-0.2
Delta time in open arm before/after self-admin0.00.00.20.1-0.1-0.0-0.30.2-0.50.00.10.0-0.0-0.2
Diff in mean of infusions in LGA sessions0.30.30.90.1-0.1-0.2-0.0-0.5-0.3-0.9-0.9-0.9-0.80.3
Delay discount exponential model param2.62.95.6-2.32.22.22.4-2.31.80.70.4-0.70.50.8
Extinction: sum of active levers before priming1.41.53.91.6-1.6-1.3-1.30.40.1-1.1-1.3-0.3-1.1-2.0
Active lever presses in extinction session 60.20.20.80.3-0.3-0.1-0.1-0.30.4-0.4-0.7-0.3-0.6-0.9
Bone: final force1.11.84.41.0-1.1-0.9-0.40.50.1-2.1-1.7-1.7-1.8-1.7
Bone: final moment1.21.94.81.0-1.1-0.9-0.40.50.0-2.2-1.8-1.9-1.9-1.6
Food consumed during 24 hour testing period0.70.92.10.8-0.9-0.70.10.20.3-1.2-1.5-1.2-1.4-1.1
Glucose0.30.41.8-0.10.0-0.00.3-0.80.6-0.5-0.6-0.8-0.71.3
Heart weight1.21.96.0-1.11.01.11.4-1.61.1-1.2-1.6-2.5-1.2-0.4
Delay discount hyperbolic model param2.63.05.9-2.42.32.22.4-2.41.70.60.3-0.90.50.9
Intermittent access intake day 1-15 change0.10.20.5-0.20.30.20.4-0.2-0.40.60.40.60.70.2
Intermittent access intake escalation0.20.30.9-0.30.40.30.3-0.1-0.50.90.70.81.00.3
Intermittent access intake escalation 20.30.30.8-0.50.50.30.50.0-0.40.90.50.60.70.8
Intermitt. access day 1 inactive lever presses0.41.43.80.5-0.6-0.6-0.6-0.5-0.1-1.8-1.4-1.9-2.01.0
Intermitt. access day 15 inactive lever presses0.51.12.41.1-1.1-1.3-1.20.4-1.5-0.9-1.0-0.8-1.00.7
Intermitt. access escalation Index0.30.41.90.00.00.00.0-0.3-0.21.00.81.41.1-0.2
Intermittent access day 1 total infusions3.15.08.93.0-3.0-2.8-2.51.9-1.4-2.1-2.1-0.9-2.1-1.7
Intermittent access day 15 total infusions1.52.24.22.0-2.0-2.0-1.81.7-1.7-0.7-0.70.3-0.7-1.1
Intermittent access terminal intake (last 3 days)1.72.34.32.1-2.0-2.0-2.01.7-1.6-0.8-1.00.1-0.8-1.2
Intermittent access total infusions5.26.111.13.3-3.3-3.2-2.92.5-2.0-2.0-2.2-0.6-2.0-1.6
Intermittent access day 1 locomotion2.43.05.22.3-2.3-2.2-1.91.5-1.4-1.7-1.9-0.7-1.5-0.6
Intermittent access day 15 total locomotion0.81.53.41.5-1.6-1.6-1.10.7-0.7-1.2-1.8-0.9-1.3-0.3
Intermittent access total locomotion2.02.55.51.7-1.8-1.9-1.10.8-1.1-1.7-2.4-1.4-1.80.2
Intermittent access standard deviation1.53.27.51.9-2.0-1.8-1.21.0-0.7-2.7-1.9-2.0-2.4-0.2
Left kidney weight2.310.827.8-2.42.22.73.6-4.05.3-2.6-2.6-4.7-2.7-1.0
Right kidney weight3.214.531.7-3.12.83.14.4-4.95.6-2.9-3.1-5.6-3.00.0
Cocaine induced anxiety0.30.41.1-0.50.50.50.9-0.91.10.2-0.9-0.6-0.2-0.1
Post-drug Anxiety1.21.32.5-1.61.61.41.5-1.30.71.10.3-0.00.80.9
Baseline Anxiety0.40.41.2-0.10.1-0.1-0.30.7-1.10.71.00.80.70.4
Tail length0.52.15.7-2.01.91.51.7-1.4-0.20.90.9-0.30.82.4
Length with tail1.04.39.7-2.82.72.53.1-2.71.50.10.3-1.50.11.9
Length without tail1.13.68.2-1.61.51.52.4-2.52.1-1.6-1.8-2.9-1.50.2
Times rat made contact with spout0.30.31.80.1-0.2-0.60.10.5-1.00.1-0.10.00.01.4
Lifetime Intake6.17.513.33.6-3.6-3.5-3.12.7-1.7-2.5-2.7-1.0-2.5-1.8
Liver weight, left0.81.32.5-1.31.31.31.4-1.11.61.10.90.50.90.5
Liver weight, right5.18.814.6-3.73.73.73.8-3.83.52.21.60.42.21.5
Locomotor activity0.61.03.8-1.11.01.11.9-1.11.2-0.3-0.4-0.9-0.3-0.4
Locomotor testing distance0.10.20.7-0.30.30.20.80.1-0.30.50.40.50.50.2
Locomotor testing rearing0.20.51.3-0.30.30.41.1-0.51.2-0.4-0.6-0.7-0.5-0.8
Locomotion in novel chamber1.72.15.5-0.91.00.90.5-0.3-0.42.22.12.42.30.6
Locomotion in novel chamber post-restriction0.50.82.90.6-0.5-0.5-0.70.6-0.21.11.01.71.0-0.6
Fecal boli incidents, locomotor time 11.42.03.21.3-1.4-1.5-1.21.3-1.8-1.6-1.6-1.5-1.60.0
Change in fecal boli incidents, locomotor task1.31.22.9-1.51.51.31.7-1.20.80.80.90.21.0-0.1
Time >=10cm from walls, locomotor time 10.70.82.60.1-0.2-0.10.2-0.50.4-1.4-1.3-1.6-1.3-0.5
Bouts of movement, locomotor time 10.20.21.0-0.40.40.30.5-1.00.8-0.0-0.2-0.4-0.20.1
Total resting periods, locomotor time 10.20.20.60.1-0.1-0.10.0-0.50.3-0.5-0.7-0.8-0.7-0.1
Rest time, locomotor task time 10.60.72.20.3-0.4-0.4-0.3-0.40.2-1.2-1.4-1.5-1.40.4
Distance moved, locomotor task time 10.81.21.9-1.21.31.41.3-0.91.21.01.10.71.1-0.0
Vertical activity count, locomotor time 10.51.23.7-1.41.31.11.6-1.10.30.50.4-0.20.61.9
Time >=10cm from walls, locomotor time 20.20.31.1-0.60.50.40.1-0.8-0.3-0.5-0.4-1.0-0.3-0.1
Bouts of movement, locomotor time 20.30.51.50.6-0.6-0.3-0.20.01.10.70.31.20.6-1.0
Total resting periods, locomotor time 20.40.61.41.1-1.1-0.8-0.70.50.70.4-0.01.00.2-1.2
Rest time, locomotor task time 20.50.61.10.9-0.9-1.0-0.80.6-0.8-0.9-0.6-0.5-0.9-0.2
Distance moved, locomotor task time 20.91.12.1-1.41.41.51.1-1.21.20.40.7-0.10.50.5
Vertical activity count, locomotor time 20.50.71.9-1.11.10.91.1-1.40.5-0.1-0.1-0.80.11.0
Light reinforcement 10.10.20.40.4-0.4-0.3-0.40.5-0.50.1-0.4-0.2-0.4-0.7
Light reinforcement 20.71.13.9-0.80.81.10.7-1.12.00.90.60.51.0-1.2
Bone: marrow area0.71.54.80.1-0.20.10.3-1.00.6-1.9-1.4-2.2-1.8-1.1
Bone: maximum diameter1.12.16.40.0-0.10.20.6-0.71.2-1.8-2.0-2.5-2.1-1.6
Bone: maximum force1.83.27.21.4-1.5-1.3-0.60.7-0.2-2.7-2.6-2.3-2.4-1.8
Bone: maximum moment1.93.37.51.4-1.5-1.3-0.50.7-0.2-2.7-2.7-2.4-2.5-1.7
Mean time between licks in bursts0.30.72.20.5-0.4-0.1-1.01.3-0.60.50.61.10.5-1.5
Mean num. licks in bursts0.40.61.5-0.80.70.61.2-1.01.0-0.3-0.1-0.6-0.20.9
Cd content in liver0.30.31.4-0.50.50.41.2-0.60.00.60.20.30.2-0.8
Co content in liver0.91.02.71.2-1.2-1.3-0.71.3-1.6-0.6-0.9-0.1-0.7-0.4
Cu content in liver1.72.05.71.2-1.1-1.3-1.81.8-2.41.00.31.91.00.0
Fe content in liver1.41.74.6-1.11.01.21.4-1.80.8-1.2-1.3-2.2-1.2-0.6
K content in liver0.10.10.40.1-0.1-0.2-0.50.4-0.40.10.60.40.40.3
Mg content in liver0.10.10.50.4-0.4-0.4-0.70.2-0.4-0.2-0.2-0.00.10.1
Mn content in liver0.30.31.0-0.10.10.1-0.2-0.20.70.61.01.00.9-0.2
Na content in liver0.10.10.7-0.20.20.1-0.10.0-0.80.2-0.20.00.40.7
Rb content in liver0.91.02.01.1-1.2-1.2-1.21.2-0.8-0.8-1.4-0.6-0.9-0.2
Se content in liver1.41.63.8-1.11.11.11.0-0.30.21.71.61.82.0-0.3
Sr content in liver1.71.54.90.4-0.3-0.5-0.81.0-1.11.51.32.21.61.2
Zn content in liver0.10.10.3-0.20.20.00.40.0-0.40.40.50.40.60.6
Bone: minimum diameter0.50.92.50.6-0.7-0.5-0.3-0.00.5-1.4-1.2-1.3-1.6-0.8
Time in familiar zone, hab. session 10.50.40.80.6-0.6-0.7-0.70.5-0.9-0.4-0.7-0.4-0.8-0.9
Time in novel zone, hab. session 10.80.82.1-1.00.91.11.4-1.21.30.2-0.0-0.30.50.0
Total zone transitions, hab. session 11.41.95.90.00.1-0.1-0.51.0-1.51.92.22.41.7-0.0
Total locomotion distance, hab. session 10.91.34.2-0.70.70.50.5-0.1-0.71.72.11.81.40.4
Locomotion velocity, hab. session 10.71.03.3-0.20.30.0-0.10.2-1.11.41.81.71.10.4
Time in familiar zone, hab. session 21.11.12.7-0.91.00.90.5-0.40.41.51.71.41.5-0.3
Time in novel zone, hab. session 21.11.12.61.0-1.1-1.1-0.30.3-0.4-1.6-1.6-1.2-1.50.5
Total zone transitions, hab. session 21.31.75.21.4-1.4-1.6-1.61.6-2.3-0.6-0.8-0.2-0.9-0.1
Total locomotion distance, hab. session 21.31.73.51.6-1.6-1.6-1.51.5-1.9-1.0-0.7-0.4-1.2-0.7
Locomotion velocity, hab. session 21.62.14.81.7-1.7-1.8-1.81.7-2.2-1.0-0.7-0.4-1.2-0.4
Novel to familiar place preference ratio1.82.05.6-1.81.71.72.4-2.11.20.80.1-0.20.60.4
Novelty place preference2.62.87.4-2.12.12.02.7-2.41.51.00.4-0.10.90.3
Time in novel zone, NPP test3.03.28.6-2.32.32.22.9-2.61.61.10.3-0.11.00.5
Total zone transitions, NPP test1.11.65.40.9-0.8-1.1-1.31.6-2.30.81.21.60.7-0.2
Total locomotion distance, NPP test0.60.83.10.9-0.8-1.0-1.11.1-1.8-0.20.40.3-0.4-0.2
Locomotion velocity, NPP test0.81.13.11.1-1.0-1.1-1.41.5-1.8-0.00.70.7-0.1-0.4
Intraocular pressure0.20.30.9-0.30.30.40.6-0.81.0-0.3-0.1-0.6-0.6-0.1
Delta distance traveled before/after self-admin1.31.43.3-1.21.10.81.5-1.70.1-0.9-0.7-1.8-0.81.3
Delta ambulatory time before/after self-admin0.91.13.9-0.80.70.51.1-1.1-0.2-1.2-1.0-2.0-1.10.9
Parametrial fat weight1.43.35.7-2.42.42.12.1-1.91.11.71.70.51.71.8
Pavlov. Cond. lever latency0.00.10.4-0.20.20.20.30.10.20.0-0.6-0.20.00.0
Pavlov. Cond. magazine entry latency1.11.43.01.6-1.6-1.5-1.71.3-1.1-0.6-0.10.4-0.6-1.0
Pavlov. Cond. change in total contacts2.32.44.92.1-2.1-2.0-2.21.9-1.6-0.9-0.60.3-0.9-0.9
Pavlov. Cond. index score0.60.81.51.2-1.2-1.1-1.20.7-0.8-0.8-0.2-0.2-0.8-0.6
Pavlov. Cond. latency score0.30.40.70.8-0.8-0.8-0.80.4-0.6-0.50.1-0.1-0.6-0.4
Pavlov. Cond. lever contacts0.30.31.00.7-0.7-0.7-1.00.5-0.8-0.30.50.3-0.30.1
Pavlov. Cond. magazine entry number1.11.43.4-1.61.61.61.8-1.51.30.40.1-0.40.50.7
Pavlov. Cond. intertrial magazine entries0.40.52.5-0.10.1-0.2-0.00.7-1.5-0.1-0.4-0.2-0.31.6
Pavlov. Cond. lever-magazine prob. diff.0.50.61.51.1-1.1-1.1-1.20.7-0.8-0.50.10.1-0.6-0.5
Pavlov. Cond. response bias0.91.12.81.4-1.4-1.4-1.71.2-0.9-0.5-0.00.2-0.6-0.5
Pavlov. Cond. lever latency0.20.31.7-0.10.10.10.30.10.40.80.40.60.4-1.3
Pavlov. Cond. magazine entry latency1.72.14.01.6-1.6-1.7-1.51.8-2.0-1.2-1.0-0.3-1.01.3
Pavlov. Cond. change in total contacts1.62.67.60.7-0.9-0.8-0.50.2-0.8-2.7-2.1-2.8-2.40.8
Pavlov. Cond. index score0.81.12.50.8-0.8-0.9-0.90.9-1.4-1.3-0.8-0.9-0.91.6
Pavlov. Cond. latency score1.01.33.00.9-0.9-1.1-1.01.1-1.6-1.3-0.8-0.8-0.91.7
Pavlov. Cond. lever contacts0.20.31.9-0.0-0.0-0.0-0.1-0.1-0.5-0.7-0.4-0.6-0.31.4
Pavlov. Cond. magazine entry number0.60.72.5-0.60.60.70.7-0.91.20.90.30.50.6-1.6
Pavlov. Cond. intertrial magazine entries0.20.30.90.4-0.4-0.5-0.4-0.40.3-0.7-0.9-0.8-0.90.3
Pavlov. Cond. lever-magazine prob. diff.0.70.92.20.7-0.7-0.8-0.80.9-1.3-1.3-0.6-0.7-0.81.5
Pavlov. Cond. response bias0.50.71.80.7-0.8-0.7-0.80.5-0.9-1.3-0.8-0.8-0.91.0
Time in closed arm before self-admin0.30.41.90.5-0.5-0.5-0.70.7-1.40.10.00.20.00.7
Time in closed arm after self-admin0.30.31.40.1-0.2-0.40.20.1-0.2-0.5-0.9-0.7-0.61.2
Time in open arm before self-admin0.40.40.9-0.80.80.70.4-0.30.30.60.90.40.80.5
Time in open arm after self-admin0.60.71.8-0.70.70.70.2-0.20.01.11.31.21.30.0
Bone: periosteal estimation0.81.64.30.4-0.5-0.20.1-0.40.8-1.9-1.6-2.1-1.9-1.5
Bone: periosteal perimeter1.22.05.3-0.40.30.60.9-1.11.7-1.6-1.4-2.3-1.7-1.8
Bone: post-yield work1.62.46.01.7-1.7-1.7-1.11.0-1.5-1.3-2.4-1.2-1.4-1.4
Progressive ratio test 1 active lever presses3.94.88.42.9-2.9-2.8-2.62.0-1.5-2.2-2.0-0.7-1.8-1.5
Progressive ratio test 1 breakpoint3.64.37.62.8-2.8-2.7-2.52.0-1.5-2.0-1.9-0.6-1.7-1.4
Progressive ratio test 1 inactive lever presses4.46.310.53.2-3.2-3.0-3.02.3-1.6-2.6-2.5-1.2-2.7-0.9
Progressive ratio test 2 active lever presses3.54.08.22.8-2.8-2.9-2.51.9-1.4-1.7-1.6-0.4-1.7-0.7
Progressive ratio test 2 breakpoint3.74.28.42.9-2.9-2.9-2.62.1-1.4-1.6-1.5-0.3-1.6-1.0
Progressive ratio test 2 inactive lever presses1.82.96.22.4-2.4-2.5-2.41.8-1.8-0.7-0.80.5-0.7-0.1
Incentive Sensitization - Responses0.30.41.00.9-0.9-1.0-0.90.7-0.4-0.00.20.5-0.30.1
Incentive Sensitization - Breakpoint0.30.41.10.9-0.9-1.1-0.90.6-0.3-0.10.00.3-0.40.1
Sum of active levers in priming session hrs 5-60.10.11.0-0.20.20.20.3-1.00.10.1-0.1-0.1-0.2-0.1
Progressive ratio0.20.31.00.5-0.5-0.5-0.30.4-0.8-0.7-1.0-0.6-0.50.2
Food seeking constrained by brief footshock0.40.51.80.8-0.8-0.7-0.20.70.3-0.5-0.9-0.2-0.3-1.3
Seeking ratio, punishment vs. effort0.10.20.80.4-0.4-0.3-0.20.30.7-0.2-0.2-0.0-0.4-0.9
Retroperitoneal fat weight1.77.421.6-3.02.93.13.8-3.74.6-0.1-0.5-2.0-0.20.0
Reaction time number correct0.81.65.6-0.70.80.70.1-0.60.61.52.42.01.8-0.5
Reaction time mean minus median0.00.00.1-0.0-0.00.1-0.1-0.3-0.1-0.20.1-0.2-0.20.2
Reaction time mean minus median AUC0.10.41.0-0.60.60.60.6-1.00.90.10.2-0.4-0.10.7
Reaction time num false alarms0.20.20.7-0.60.60.60.8-0.30.10.40.50.30.5-0.0
Reaction time num false alarms AUC0.20.30.7-0.60.60.60.8-0.2-0.00.60.70.50.6-0.0
Reaction time trials correct on left0.81.65.6-0.70.80.70.1-0.60.61.52.42.01.8-0.5
Reaction time trials on left0.91.65.8-0.60.70.70.1-0.50.51.52.42.11.9-0.5
Reaction time mean0.10.20.6-0.30.30.40.1-0.70.1-0.30.0-0.50.00.8
Reaction time mean AUC0.10.10.5-0.30.30.30.1-0.60.1-0.10.1-0.30.10.7
Median of all reaction times0.10.10.4-0.30.30.3-0.0-0.50.1-0.30.1-0.40.10.6
Reaction time omissions0.71.12.61.4-1.3-1.1-1.31.0-0.60.00.51.20.2-1.6
Reaction time false alarm rate0.10.10.5-0.30.30.30.70.0-0.10.1-0.3-0.3-0.00.3
Reaction time premature initiation rate1.42.05.71.2-1.3-1.2-0.50.3-0.8-2.0-1.7-1.8-2.4-0.4
Reaction time premature initiations0.30.62.00.7-0.8-0.7-0.3-0.2-0.4-1.2-0.5-0.8-1.4-0.4
Std. dev. reaction times0.20.31.1-0.60.50.60.6-1.10.3-0.20.1-0.6-0.10.6
Reaction time trials completed0.91.65.8-0.60.70.70.1-0.50.51.52.42.11.9-0.5
Reaction time trials AUC0.71.44.7-0.70.80.70.2-0.60.71.32.21.81.7-0.5
Run reversals in cocaine runway, females0.80.81.7-1.21.21.01.0-0.80.21.30.90.30.40.4
Run reversals in cocaine runway, males0.10.10.3-0.10.1-0.1-0.10.6-0.2-0.2-0.2-0.5-0.30.4
Latency to leave start box in cocaine runway0.50.62.9-0.50.50.80.1-0.71.70.30.20.10.4-1.3
Latency to leave start box in cocaine runway, F0.30.42.90.3-0.20.1-0.70.60.6-0.00.10.10.1-1.7
Latency to leave start box in cocaine runway, M1.61.44.8-1.21.21.41.1-2.22.10.50.40.10.60.1
Std. dev. time between licks in bursts0.30.41.60.4-0.4-0.4-0.71.1-1.3-0.7-0.1-0.3-0.40.4
Total sessions with >9 infusions3.84.68.22.4-2.4-2.2-1.91.5-0.0-2.9-2.9-1.9-2.5-1.6
Short access day 1 total inactive lever presses4.35.610.72.0-2.1-2.1-1.71.5-2.1-3.1-3.3-3.0-3.10.2
Short access day 10 total inactive lever presses0.51.25.1-1.00.90.60.7-1.40.2-0.3-0.7-1.6-0.82.2
Short access day 1 total infusions1.92.54.51.6-1.7-1.6-1.61.2-0.8-2.0-2.1-1.7-1.9-0.1
Short access day 10 total infusions2.73.55.82.2-2.2-2.0-1.71.2-0.3-2.4-2.3-1.4-2.2-1.6
Short access total infusions4.86.19.43.0-3.0-2.8-2.51.9-0.7-2.9-3.1-1.8-2.7-1.7
Short access day 1 locomotion1.01.33.11.0-1.1-1.0-0.90.8-0.6-1.8-1.3-1.4-1.30.2
Short access day 10 total locomotion1.12.04.71.4-1.5-1.5-1.20.6-1.1-2.2-1.3-1.3-1.81.4
Short access total locomotion2.02.46.11.6-1.7-1.6-1.21.0-0.4-2.5-1.9-1.6-1.90.1
One hour access (0.3 mA shock)4.34.99.83.1-3.1-3.0-3.02.9-2.0-0.6-1.01.0-0.7-1.3
Compulsive drug intake0.40.41.40.2-0.1-0.5-0.60.4-1.20.80.40.70.51.1
One hour access (shock baseline)1.32.04.02.0-2.0-1.7-1.71.8-0.6-0.7-0.80.4-0.7-1.6
Social response proportion0.70.86.90.6-0.6-0.0-0.40.30.4-0.8-0.4-0.4-0.5-2.6
Social responses0.91.12.31.2-1.2-1.1-0.91.5-1.0-0.8-0.5-0.2-0.9-1.5
Social time1.92.55.12.1-2.1-2.0-2.02.3-1.8-1.0-0.20.4-0.8-0.8
Soleus weight0.51.43.90.9-1.0-1.5-0.51.2-1.8-1.0-0.2-0.7-1.02.0
Bone: stiffness1.11.84.70.8-0.9-0.7-0.20.20.1-2.1-2.2-2.1-1.8-1.3
Tibialis anterior weight1.13.89.52.4-2.3-2.3-2.23.1-2.60.30.22.00.4-0.2
Time to tail flick, vehicle, before self-admin0.20.20.40.3-0.3-0.40.1-0.4-0.5-0.4-0.6-0.4-0.6-0.2
Time to tail flick, vehicle, after self-admin0.50.62.0-1.01.00.71.0-0.7-0.80.00.4-0.50.11.4
Time to tail flick, test, before self-admin0.30.31.00.4-0.4-0.3-0.21.00.70.60.30.80.3-0.3
Time to tail flick, test, after self-admin0.30.31.0-0.40.50.30.0-0.1-0.30.60.60.61.00.7
Delta time to tail flick, vehicle, before/after SA0.20.20.60.1-0.1-0.1-0.20.5-0.4-0.7-0.4-0.8-0.50.3
Delta time to tail flick, test, before/after SA0.80.81.9-0.70.70.50.3-0.6-1.11.01.01.01.41.1
Tibia length0.30.72.10.3-0.3-0.30.3-0.50.4-1.3-0.9-1.4-1.4-0.8
Ambulatory time before self-admin0.71.02.21.4-1.4-1.3-1.51.4-1.0-0.6-0.10.5-0.1-0.5
Ambulatory time after self-admin0.60.83.20.6-0.6-0.8-0.50.4-1.8-1.2-0.6-0.9-0.70.3
Bone: tissue strength0.20.20.5-0.50.50.50.7-0.60.7-0.20.0-0.40.0-0.1
Total heroin consumption0.91.12.11.5-1.5-1.4-0.91.0-0.5-0.6-0.90.0-0.7-1.3
Bone: trabecular number0.30.51.0-0.80.80.80.6-0.60.50.71.00.50.7-0.1
Bone: trabecular spacing1.31.84.21.1-1.2-1.2-0.50.3-0.4-1.9-2.0-1.9-1.9-0.5
Bone: trabecular thickness0.70.91.9-0.90.91.00.3-0.60.81.21.41.11.20.5
Bone: trabecular tissue density0.40.51.2-0.80.80.70.40.2-0.71.00.30.61.01.1
Water consumed over 24 hours0.30.41.30.3-0.4-0.70.20.6-1.0-0.6-0.5-0.5-0.51.1
Number of responses in last shaping day5.35.911.03.3-3.3-3.0-3.12.6-1.3-2.3-1.9-0.6-2.0-1.6