Hub : Genes

Dleu7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Dleu7 0.45 0.04 0.0e+00 0.49 0.55 0.54 0.54 1.3e-51 3.6e-61 1.4e-58 3.9e-60
2 NAcc gene expression Dleu7 0.68 0.07 0.0e+00 0.58 0.62 0.62 0.62 4.0e-110 1.5e-120 8.6e-123 3.9e-121
3 BLA gene expression Dleu7 0.67 0.09 0.0e+00 0.52 0.51 0.54 0.54 4.8e-32 3.9e-31 3.2e-33 1.4e-33
4 RMTg gene expression Dleu7 0.54 0.16 1.7e-12 0.35 0.37 0.3 0.38 3.6e-10 7.2e-11 1.4e-08 3.2e-11
5 pVTA gene expression Dleu7 0.62 0.09 0.0e+00 0.52 0.59 0.6 0.6 3.0e-48 9.2e-59 2.7e-59 6.5e-60
6 IL gene expression Dleu7 0.44 0.16 1.8e-06 0.14 0.15 0.13 0.14 3.3e-04 1.7e-04 6.1e-04 3.4e-04
7 IC gene expression Dleu7 0.62 0.12 0.0e+00 0.36 0.42 0.43 0.44 4.5e-16 2.8e-19 1.3e-19 2.9e-20
8 LHb gene expression Dleu7 0.5 0.13 9.9e-11 0.3 0.27 0.3 0.29 5.9e-08 3.8e-07 8.5e-08 1.5e-07
9 PL gene expression Dleu7 0.56 0.11 0.0e+00 0.42 0.51 0.51 0.52 4.8e-50 3.3e-64 9.0e-64 1.9e-65
10 Eye gene expression Dleu7 0.29 0.16 6.7e-03 0.02 0.1 0.07 0.07 1.5e-01 1.2e-02 3.6e-02 2.8e-02
11 OFC gene expression Dleu7 0.69 0.15 3.3e-09 0.23 0.2 0.22 0.22 3.2e-06 1.3e-05 5.9e-06 6.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.61.00.90.80.90.80.60.70.90.51.00.20.7
Area under the delay curve2.83.36.5-2.2-1.5-1.7-1.9-1.1-2.5-2.0-1.9-2.3-1.0-1.1
BMI with tail1.34.67.1-2.0-2.7-2.5-2.1-2.7-1.2-2.0-2.2-1.7-2.5-1.8
BMI without tail0.20.61.9-0.5-1.3-0.8-0.6-1.40.0-0.5-0.3-0.3-1.1-0.3
Body weight1.35.87.9-2.5-2.8-2.6-2.4-2.6-2.4-2.6-2.4-2.5-2.2-0.9
Weight adjusted by age1.52.33.6-1.5-1.4-1.6-1.6-1.5-1.2-1.3-1.5-1.2-1.9-1.9
Bone surface0.50.92.00.90.91.10.90.80.60.90.81.00.91.4
Bone volume0.40.81.80.90.91.00.80.70.40.90.61.00.71.4
Breakpoint value in progressive ratio session0.70.81.1-1.0-1.0-0.9-0.9-0.8-1.0-1.0-0.8-1.0-0.8-0.5
Number of licking bursts0.10.10.4-0.3-0.4-0.4-0.5-0.6-0.10.0-0.5-0.0-0.5-0.1
Context. condit. distance diff. score0.30.30.80.90.80.50.80.90.50.40.30.30.10.1
Locomotion velocity, session 12.12.32.9-1.6-1.7-1.6-1.6-1.6-1.2-1.5-1.2-1.4-1.5-1.6
Locomotion distance, session 11.01.31.9-1.3-1.1-1.1-1.4-1.2-1.1-1.0-1.2-0.9-1.1-1.2
Locomotion velocity, session 20.10.10.5-0.2-0.0-0.3-0.4-0.1-0.7-0.2-0.7-0.1-0.6-0.1
Locomotion distance, session 20.10.10.30.20.20.2-0.1-0.0-0.10.4-0.30.4-0.5-0.0
Locomotion velocity, session 30.91.13.4-0.5-0.7-1.0-1.0-0.8-0.7-0.6-1.3-0.6-1.8-1.5
Locomotion distance, session 30.80.92.3-0.7-0.8-0.8-1.0-0.8-0.9-0.7-1.0-0.7-1.5-1.2
Stereotopy head waving bouts, day 30.91.01.41.21.21.01.01.11.01.10.71.00.91.0
Stereotopy head waving duration, day 30.10.10.2-0.3-0.2-0.3-0.3-0.2-0.2-0.2-0.5-0.2-0.10.1
Locomotion velocity, session 70.50.51.21.10.50.40.50.20.81.00.51.0-0.9-0.5
Locomotion distance, session 72.32.94.62.12.11.81.61.71.82.11.62.00.70.4
Stereotopy head waving bouts, day 73.23.74.7-1.8-2.1-2.2-1.8-1.9-1.6-1.9-2.0-1.8-1.9-1.8
Stereotopy head waving duration, day 74.14.96.4-2.1-2.3-2.4-2.2-2.1-2.1-2.1-2.5-2.1-2.3-2.0
Locomotion velocity, session 80.20.21.0-0.10.3-0.0-0.20.4-1.0-0.4-0.7-0.5-0.30.2
Locomotion distance, session 80.10.10.30.30.40.10.10.4-0.20.1-0.4-0.0-0.6-0.5
Degree of sensitization distance6.97.18.62.82.82.72.62.42.92.92.72.82.42.0
Degree of sensitization stereotypy3.94.35.1-2.1-2.2-2.2-2.0-1.8-2.1-2.3-2.0-2.3-1.8-2.0
Conditioned locomotion1.21.44.91.11.91.31.22.20.00.60.60.21.2-0.1
Cocaine response after cond. corrected0.40.51.50.60.50.60.80.70.30.40.60.40.81.2
Cocaine response after cond. not corrected0.30.41.20.40.50.60.60.70.20.40.60.30.91.1
Cocaine response before conditioning0.70.91.8-1.1-0.8-0.9-1.1-0.9-0.8-0.9-0.6-0.9-0.8-1.3
Saline control response0.20.31.2-0.30.40.10.20.7-0.5-0.50.4-0.71.10.4
Bone: connectivity density0.71.01.61.31.21.11.21.11.01.01.01.00.60.3
Bone: cortical apparent density1.31.82.8-1.3-1.6-1.6-1.3-1.7-0.7-1.3-1.3-1.1-1.5-1.3
Bone: cortical area0.00.00.20.1-0.10.00.1-0.10.00.10.00.2-0.00.5
Bone: cortical porosity1.31.43.8-1.2-0.6-0.9-1.1-0.1-2.0-1.4-1.1-1.5-0.7-1.2
Bone: cortical porosity1.61.74.5-1.4-0.6-1.1-1.2-0.1-2.1-1.6-1.1-1.8-0.7-1.3
Bone: cortical thickness0.30.50.8-0.8-0.9-0.8-0.8-0.8-0.6-0.8-0.7-0.7-0.8-0.4
Bone: cortical thickness1.31.52.3-1.1-1.2-1.3-1.2-1.1-1.1-1.2-1.2-1.1-1.5-1.4
Bone: cortical tissue density1.31.82.7-1.3-1.6-1.6-1.3-1.6-0.6-1.2-1.3-1.1-1.5-1.2
Condit. Reinf. active minus inactive responses2.42.64.0-1.7-1.9-1.7-1.7-2.0-1.0-1.5-1.3-1.3-1.7-1.6
Condit. Reinf. active-inactive response ratio0.20.20.7-0.3-0.7-0.4-0.4-0.80.3-0.1-0.10.1-0.6-0.4
Condit. Reinf. active responses3.84.86.0-2.4-2.3-2.2-2.3-2.2-1.7-2.3-1.6-2.2-2.2-2.5
Condit. Reinf. inactive responses2.02.54.2-1.9-1.2-1.4-1.6-1.0-1.8-2.0-1.2-2.0-1.0-1.6
Incentive salience index mean4.45.46.6-2.5-2.6-2.4-2.4-2.6-1.7-2.3-1.9-2.1-2.4-2.5
Condit. Reinf. lever presses5.27.310.0-2.9-2.8-2.8-2.8-2.8-2.0-2.7-2.3-2.5-2.7-3.2
Condit. Reinf. active minus inactive responses0.70.82.8-0.9-1.0-0.9-0.8-1.0-0.2-0.8-0.2-0.8-0.8-1.7
Condit. Reinf. active-inactive response ratio1.11.23.7-0.8-1.2-1.2-0.9-1.3-0.0-0.7-0.7-0.6-1.5-1.9
Condit. Reinf. active responses0.91.23.0-1.2-1.1-1.1-1.1-1.1-0.6-1.1-0.7-1.1-0.9-1.7
Condit. Reinf. inactive responses0.30.31.30.20.70.70.50.80.10.30.6-0.01.10.3
Condit. Reinf. lever presses4.56.37.5-2.6-2.7-2.6-2.7-2.7-1.8-2.3-2.6-2.1-2.6-2.7
Condit. Reinf. lever reinforcers received1.41.93.7-1.6-1.4-1.4-1.4-1.4-0.8-1.4-0.9-1.4-1.1-1.9
Conditioned reinforcement - actives3.86.69.92.53.02.82.62.82.72.23.12.02.71.1
Conditioned reinforcement - inactives5.27.69.93.13.02.92.82.72.92.92.72.92.22.0
Conditioned locomotion2.02.54.11.41.91.71.62.01.41.22.00.91.90.9
Patch foraging indifference point 0 sec0.40.73.90.30.70.80.40.7-0.20.30.20.31.32.0
Patch foraging indifference point AUC0.20.30.90.6-0.00.10.2-0.40.90.8-0.40.9-0.50.3
Delay disc. indifference point, 0s delay0.10.10.4-0.30.1-0.1-0.10.3-0.7-0.4-0.4-0.70.1-0.1
Delay disc. indifference point, 16s delay0.70.82.8-1.2-0.2-0.4-0.80.1-1.7-1.0-0.8-1.30.3-0.0
Delay disc. indifference point, 2s delay1.71.82.9-1.5-1.1-1.3-1.3-0.8-1.7-1.5-1.5-1.7-0.9-1.2
Delay disc. indifference point, 24s delay0.50.51.2-1.1-0.7-0.7-0.9-0.6-1.0-0.7-0.7-0.6-0.2-0.2
Delay disc. indifference point, 4s delay3.73.96.1-2.2-1.7-1.9-1.8-1.3-2.4-2.3-1.9-2.5-1.6-1.8
Delay disc. indifference point, 8s delay1.92.24.3-1.8-1.3-1.4-1.6-1.1-2.1-1.6-1.7-1.7-0.7-0.5
Indifference point function ln k0.30.41.3-0.9-0.3-0.4-0.50.0-1.1-1.1-0.1-1.00.2-0.2
Indifference point function log k0.30.41.3-0.9-0.3-0.4-0.50.0-1.1-1.1-0.1-1.00.2-0.2
Patch foraging total patch changes 0 sec0.30.53.2-0.20.40.4-0.10.4-0.7-0.2-0.3-0.11.01.8
Patch foraging total patch changes 12 sec0.40.51.3-0.7-0.7-0.5-0.7-1.0-0.5-0.2-1.10.0-0.40.8
Patch foraging total patch changes 18 sec0.10.20.8-0.3-0.0-0.0-0.3-0.1-0.5-0.1-0.7-0.00.20.9
Patch foraging total patch changes 24 sec0.30.52.7-0.7-0.2-0.3-0.8-0.3-1.0-0.5-1.7-0.4-0.20.4
Patch foraging total patch changes 6 sec0.10.21.40.1-0.10.2-0.0-0.30.30.4-0.30.50.31.2
Patch foraging time to switch 0 sec0.10.30.70.50.80.40.50.80.20.50.30.30.3-0.7
Patch foraging water rate 0 sec0.51.12.0-1.3-1.1-0.9-1.1-0.9-1.4-1.4-0.8-1.2-0.50.4
Patch foraging water rate 12 sec2.14.48.1-2.6-1.8-2.0-2.2-1.3-2.9-2.7-1.7-2.7-1.1-1.0
Patch foraging water rate 18 sec4.77.39.6-3.1-2.8-2.6-3.0-2.5-3.1-3.0-2.6-2.8-2.3-1.3
Patch foraging water rate 24 sec1.01.53.5-1.5-0.9-0.9-1.3-0.5-1.9-1.7-0.8-1.8-0.3-0.3
Patch foraging water rate 6 sec2.23.16.7-2.2-1.3-1.6-1.9-1.0-2.6-2.3-1.7-2.3-0.7-0.5
Seeking ratio, delayed vs. immediate footshock1.21.53.21.21.31.21.51.80.80.51.70.31.60.6
Distance traveled before self-admin0.20.30.7-0.4-0.0-0.5-0.40.2-0.7-0.8-0.6-0.8-0.3-0.8
Distance traveled after self-admin0.20.20.90.10.60.30.41.0-0.2-0.20.5-0.50.6-0.2
Extensor digitorum longus weight6.124.232.0-5.2-4.5-5.2-5.2-4.0-5.7-5.3-5.5-5.1-4.4-3.7
Bone: elastic displacement0.70.81.80.61.21.00.81.4-0.00.40.60.31.31.0
Bone: elastic work0.10.20.6-0.40.1-0.1-0.30.2-0.8-0.4-0.6-0.40.30.5
Bone: endosteal estimation0.81.72.31.51.41.41.41.31.11.41.21.31.01.2
Bone: endosteal perimeter1.32.83.51.81.81.91.91.81.41.61.61.51.51.3
Epididymis fat weight0.20.62.5-0.40.2-0.40.10.9-1.1-1.2-0.2-1.60.4-0.4
Delta time in closed arm before/after self-admin0.00.00.20.1-0.1-0.30.10.0-0.1-0.2-0.4-0.2-0.00.2
Delta time in open arm before/after self-admin1.71.72.91.40.81.41.20.51.71.61.41.70.71.0
Diff in mean of infusions in LGA sessions0.10.10.6-0.10.20.2-0.30.1-0.7-0.2-0.8-0.2-0.10.5
Delay discount exponential model param4.24.78.02.61.92.12.31.52.82.42.32.61.41.4
Extinction: sum of active levers before priming0.10.20.3-0.5-0.0-0.2-0.5-0.0-0.5-0.3-0.5-0.4-0.3-0.6
Active lever presses in extinction session 60.10.10.2-0.10.40.1-0.20.4-0.3-0.1-0.3-0.10.1-0.3
Bone: final force0.50.81.7-0.9-0.4-0.9-0.9-0.3-1.2-1.0-1.3-1.0-0.7-0.6
Bone: final moment0.71.12.1-1.0-0.6-1.0-1.0-0.4-1.4-1.2-1.5-1.2-0.8-0.7
Food consumed during 24 hour testing period0.20.20.5-0.5-0.7-0.7-0.5-0.7-0.3-0.4-0.3-0.3-0.5-0.2
Glucose0.20.31.0-0.2-0.6-0.3-0.5-1.00.20.1-0.60.4-0.90.2
Heart weight0.30.40.8-0.8-0.9-0.7-0.8-0.9-0.3-0.5-0.1-0.4-0.6-0.8
Delay discount hyperbolic model param3.84.27.32.41.82.02.11.42.72.32.12.51.31.4
Intermittent access intake day 1-15 change0.91.92.81.51.71.51.31.51.21.41.01.31.31.2
Intermittent access intake escalation0.61.31.81.31.41.21.11.30.91.20.71.01.11.1
Intermittent access intake escalation 20.80.91.51.10.91.00.90.80.91.20.61.10.60.9
Intermitt. access day 1 inactive lever presses2.38.512.43.22.73.02.72.13.43.42.93.52.32.5
Intermitt. access day 15 inactive lever presses1.12.23.11.71.61.61.61.51.51.61.51.51.10.8
Intermitt. access escalation Index0.20.31.0-0.4-0.6-0.3-0.7-1.00.10.3-0.50.5-0.50.1
Intermittent access day 1 total infusions0.91.53.01.11.71.41.11.61.00.81.10.81.50.9
Intermittent access day 15 total infusions2.63.96.82.12.62.21.92.41.71.91.61.71.91.4
Intermittent access terminal intake (last 3 days)3.34.47.02.42.72.32.02.32.12.21.62.11.71.5
Intermittent access total infusions4.35.18.22.32.92.52.22.62.12.12.02.02.31.7
Intermittent access day 1 locomotion0.40.51.00.51.00.80.60.90.50.50.70.60.80.7
Intermittent access day 15 total locomotion1.83.45.11.72.32.01.62.01.31.91.21.81.92.2
Intermittent access total locomotion1.51.82.91.31.71.51.31.61.21.31.21.21.41.3
Intermittent access standard deviation0.61.12.70.81.61.20.91.60.20.70.70.51.51.0
Left kidney weight1.88.211.5-2.8-3.2-3.0-3.0-3.3-2.2-2.6-2.7-2.4-3.4-2.7
Right kidney weight3.515.720.4-4.1-4.5-4.3-4.1-4.5-3.2-3.8-3.7-3.6-4.2-3.4
Cocaine induced anxiety0.81.12.1-1.1-0.7-0.9-0.9-0.3-1.3-1.4-0.9-1.5-0.6-1.3
Post-drug Anxiety0.20.20.7-0.20.1-0.2-0.10.4-0.5-0.6-0.2-0.7-0.1-0.8
Baseline Anxiety0.10.10.40.4-0.00.10.2-0.20.60.50.40.5-0.2-0.2
Tail length0.10.20.7-0.6-0.4-0.3-0.3-0.2-0.8-0.7-0.1-0.7-0.10.2
Length with tail0.10.31.4-0.20.10.10.00.4-0.9-0.4-0.1-0.50.51.2
Length without tail0.41.33.0-1.3-0.8-1.0-1.1-0.6-1.7-1.3-1.5-1.4-0.40.3
Times rat made contact with spout0.20.20.5-0.4-0.2-0.2-0.5-0.3-0.6-0.1-0.6-0.0-0.20.7
Lifetime Intake4.25.18.02.32.82.52.22.62.22.12.11.92.31.6
Liver weight, left2.84.68.0-2.8-2.3-2.1-2.4-2.2-2.2-2.3-2.1-2.2-1.3-1.2
Liver weight, right0.20.30.8-0.7-0.6-0.3-0.4-0.5-0.7-0.5-0.1-0.50.30.9
Locomotor activity2.64.18.5-2.4-1.9-1.9-2.2-1.5-2.9-2.4-2.1-2.4-1.3-0.5
Locomotor testing distance0.20.31.1-0.4-0.1-0.1-0.20.2-1.0-0.6-0.1-0.70.61.1
Locomotor testing rearing0.20.41.1-0.7-0.8-0.4-0.6-0.7-0.6-0.4-0.2-0.30.31.0
Locomotion in novel chamber1.82.42.9-1.6-1.7-1.7-1.4-1.3-1.7-1.6-1.5-1.6-1.4-1.4
Locomotion in novel chamber post-restriction0.20.30.90.60.90.40.50.9-0.30.30.00.2-0.0-0.4
Fecal boli incidents, locomotor time 11.82.64.4-1.8-2.0-1.8-1.8-2.1-1.4-1.4-1.7-1.2-1.4-0.3
Change in fecal boli incidents, locomotor task2.02.03.41.81.91.71.51.81.01.51.01.21.00.6
Time >=10cm from walls, locomotor time 10.20.20.9-0.2-0.1-0.4-0.2-0.0-0.4-0.4-0.5-0.7-0.5-0.9
Bouts of movement, locomotor time 10.40.40.9-0.5-1.0-0.8-0.6-0.9-0.6-0.5-0.6-0.2-0.8-0.1
Total resting periods, locomotor time 10.30.30.9-0.4-0.9-0.7-0.5-0.9-0.5-0.3-0.6-0.1-0.70.1
Rest time, locomotor task time 12.02.56.6-1.4-2.1-1.7-1.7-2.6-0.8-0.8-1.6-0.4-2.0-0.6
Distance moved, locomotor task time 11.11.63.71.21.71.31.41.90.80.81.30.51.60.5
Vertical activity count, locomotor time 10.92.15.80.92.01.51.32.4-0.20.51.20.02.31.3
Time >=10cm from walls, locomotor time 20.10.20.70.50.80.50.40.90.00.2-0.0-0.10.1-0.5
Bouts of movement, locomotor time 20.10.10.3-0.3-0.6-0.3-0.2-0.6-0.2-0.1-0.10.2-0.20.4
Total resting periods, locomotor time 20.20.31.0-0.5-0.9-0.6-0.5-1.0-0.3-0.2-0.50.1-0.60.3
Rest time, locomotor task time 22.22.86.6-1.8-2.1-1.6-2.0-2.6-1.0-1.0-1.7-0.5-2.0-0.7
Distance moved, locomotor task time 20.40.51.80.20.90.60.51.3-0.2-0.20.4-0.51.2-0.1
Vertical activity count, locomotor time 20.81.13.70.21.30.70.91.9-0.4-0.31.0-0.91.90.3
Light reinforcement 10.20.51.5-0.7-0.4-0.7-0.8-0.2-1.2-0.7-0.9-0.9-0.5-0.2
Light reinforcement 20.81.22.41.11.31.11.31.50.60.81.40.41.30.9
Bone: marrow area0.91.92.41.61.41.51.51.41.21.41.31.31.11.2
Bone: maximum diameter0.91.82.61.41.31.51.51.30.91.31.31.21.31.6
Bone: maximum force0.40.61.8-0.7-0.1-0.6-0.70.1-1.3-0.9-1.3-1.0-0.3-0.3
Bone: maximum moment0.50.92.3-1.0-0.3-0.8-0.9-0.2-1.5-1.2-1.5-1.2-0.5-0.5
Mean time between licks in bursts0.20.41.10.60.20.50.5-0.11.00.80.61.00.30.6
Mean num. licks in bursts0.10.10.4-0.3-0.10.1-0.10.0-0.5-0.30.1-0.20.30.6
Cd content in liver0.40.51.6-0.8-0.9-0.5-0.7-1.0-0.7-0.3-0.4-0.00.11.3
Co content in liver0.30.41.3-0.7-0.2-0.4-0.7-0.2-1.1-0.4-1.0-0.4-0.10.6
Cu content in liver1.72.04.2-1.1-1.4-1.5-1.5-1.6-0.9-0.9-1.7-0.7-2.0-1.7
Fe content in liver0.60.71.70.90.80.70.90.81.10.81.30.80.5-0.0
K content in liver0.70.61.91.11.40.70.81.30.50.6-0.10.40.1-0.4
Mg content in liver2.22.23.71.81.91.61.61.71.31.51.11.31.21.0
Mn content in liver1.31.52.91.21.71.21.21.60.91.00.70.71.41.1
Na content in liver2.32.55.5-1.3-1.0-1.5-1.4-0.8-1.4-1.6-1.9-1.8-1.7-2.3
Rb content in liver3.74.35.52.02.32.22.12.21.62.01.81.72.32.3
Se content in liver2.53.03.91.61.81.91.71.81.21.62.01.42.01.8
Sr content in liver0.50.51.30.6-0.10.40.4-0.41.11.00.71.1-0.10.5
Zn content in liver0.40.52.50.30.40.70.20.20.20.7-0.10.80.81.6
Bone: minimum diameter0.30.61.40.80.70.80.80.70.50.80.70.80.61.2
Time in familiar zone, hab. session 10.50.50.8-0.8-0.6-0.7-0.7-0.5-0.5-0.8-0.5-0.8-0.5-0.9
Time in novel zone, hab. session 10.80.81.91.00.81.00.80.70.51.00.51.00.71.4
Total zone transitions, hab. session 10.50.71.2-0.8-0.7-0.8-1.0-0.8-0.8-0.6-1.1-0.6-0.9-1.0
Total locomotion distance, hab. session 10.10.10.50.00.30.0-0.20.2-0.30.1-0.7-0.0-0.1-0.1
Locomotion velocity, hab. session 10.20.20.7-0.40.1-0.3-0.50.1-0.7-0.4-0.9-0.6-0.2-0.6
Time in familiar zone, hab. session 20.50.61.80.30.80.60.71.2-0.00.00.9-0.21.30.6
Time in novel zone, hab. session 20.30.31.1-0.0-0.6-0.4-0.4-0.90.10.1-0.70.3-1.0-0.3
Total zone transitions, hab. session 21.82.34.0-1.6-1.0-1.3-1.7-1.0-1.9-1.5-2.0-1.5-1.3-1.4
Total locomotion distance, hab. session 20.70.92.7-0.9-0.2-0.6-1.0-0.2-1.6-0.8-1.7-0.9-0.6-0.5
Locomotion velocity, hab. session 20.81.13.0-1.1-0.4-0.7-1.3-0.4-1.7-0.9-1.7-1.0-0.8-0.6
Novel to familiar place preference ratio1.51.62.61.61.31.41.31.11.41.51.21.50.70.5
Novelty place preference1.41.52.61.61.31.41.31.11.41.51.11.50.60.5
Time in novel zone, NPP test1.31.42.41.51.21.31.21.01.31.41.11.40.50.4
Total zone transitions, NPP test1.01.42.2-1.3-1.1-1.1-1.4-1.1-1.3-1.1-1.5-1.0-1.1-1.0
Total locomotion distance, NPP test0.10.20.60.20.30.4-0.1-0.10.30.7-0.30.80.00.5
Locomotion velocity, NPP test0.10.20.60.20.30.3-0.2-0.20.20.7-0.50.8-0.10.4
Intraocular pressure1.52.15.81.11.21.51.51.31.41.12.41.01.91.1
Delta distance traveled before/after self-admin1.31.42.91.10.81.21.20.81.41.21.71.21.21.0
Delta ambulatory time before/after self-admin0.91.11.70.91.01.10.90.91.01.11.30.91.21.0
Parametrial fat weight1.73.96.41.72.12.31.92.21.21.52.11.32.32.5
Pavlov. Cond. lever latency2.43.05.01.92.11.81.82.20.91.51.01.41.72.1
Pavlov. Cond. magazine entry latency0.20.20.6-0.5-0.7-0.4-0.3-0.70.2-0.40.2-0.3-0.1-0.8
Pavlov. Cond. change in total contacts1.11.12.3-1.5-1.5-1.1-1.1-1.5-0.8-1.1-0.5-1.0-0.4-0.4
Pavlov. Cond. index score2.93.65.6-2.2-2.4-2.0-2.0-2.4-1.3-1.8-1.2-1.6-1.7-2.0
Pavlov. Cond. latency score2.73.45.6-2.1-2.3-2.0-1.9-2.4-1.1-1.7-1.1-1.5-1.6-2.1
Pavlov. Cond. lever contacts2.02.44.1-1.7-1.9-1.6-1.6-2.0-0.8-1.4-0.9-1.2-1.5-1.9
Pavlov. Cond. magazine entry number1.41.82.91.61.71.41.41.70.91.40.91.21.01.3
Pavlov. Cond. intertrial magazine entries1.61.92.6-1.5-1.2-1.5-1.4-1.1-1.4-1.6-1.3-1.6-1.3-1.4
Pavlov. Cond. lever-magazine prob. diff.2.83.45.4-2.1-2.3-2.0-1.9-2.3-1.2-1.7-1.3-1.5-1.7-1.8
Pavlov. Cond. response bias2.12.53.5-1.8-1.9-1.6-1.7-1.9-1.1-1.6-1.1-1.4-1.4-1.9
Pavlov. Cond. lever latency3.75.06.62.42.32.42.42.41.82.12.61.92.32.0
Pavlov. Cond. magazine entry latency1.92.33.8-1.6-1.4-1.6-1.4-0.9-1.7-1.9-1.3-1.9-1.1-1.6
Pavlov. Cond. change in total contacts3.65.77.6-2.6-2.3-2.5-2.6-2.2-2.4-2.4-2.8-2.3-2.1-1.9
Pavlov. Cond. index score4.15.56.9-2.6-2.4-2.5-2.5-2.2-2.3-2.4-2.5-2.4-2.0-2.0
Pavlov. Cond. latency score4.15.56.8-2.6-2.4-2.5-2.4-2.1-2.2-2.5-2.4-2.4-2.0-2.1
Pavlov. Cond. lever contacts3.85.27.2-2.4-2.3-2.4-2.4-2.3-2.0-2.2-2.7-2.0-2.3-1.9
Pavlov. Cond. magazine entry number2.02.53.11.71.61.71.61.41.61.71.51.81.31.4
Pavlov. Cond. intertrial magazine entries2.13.15.21.81.21.81.60.72.32.21.92.31.21.6
Pavlov. Cond. lever-magazine prob. diff.4.05.36.8-2.6-2.3-2.4-2.4-2.1-2.2-2.5-2.4-2.4-1.9-2.0
Pavlov. Cond. response bias4.25.76.6-2.6-2.4-2.5-2.5-2.2-2.2-2.4-2.6-2.3-2.2-2.2
Time in closed arm before self-admin0.30.40.9-0.6-0.4-0.6-0.7-0.5-0.8-0.6-0.9-0.5-0.9-0.7
Time in closed arm after self-admin1.61.72.6-1.3-1.2-1.5-1.2-1.0-1.6-1.6-1.6-1.4-0.9-0.6
Time in open arm before self-admin0.30.41.2-0.5-0.1-0.5-0.20.4-1.0-1.0-0.3-1.10.1-0.4
Time in open arm after self-admin0.70.71.61.10.60.90.80.31.31.10.81.20.10.4
Bone: periosteal estimation0.61.31.71.31.01.21.20.91.01.21.11.20.81.3
Bone: periosteal perimeter0.50.81.01.00.71.00.90.70.81.00.91.00.70.9
Bone: post-yield work0.10.20.40.20.60.50.20.5-0.20.3-0.20.30.50.6
Progressive ratio test 1 active lever presses1.01.32.11.11.41.21.11.11.41.01.21.11.00.6
Progressive ratio test 1 breakpoint0.91.11.71.01.31.11.01.01.31.01.11.11.00.7
Progressive ratio test 1 inactive lever presses1.82.64.11.61.71.71.41.31.71.91.42.01.41.6
Progressive ratio test 2 active lever presses2.32.75.82.01.61.51.51.02.41.91.42.20.80.9
Progressive ratio test 2 breakpoint2.02.34.91.81.51.41.40.92.21.81.22.00.70.8
Progressive ratio test 2 inactive lever presses2.03.37.02.21.61.71.71.02.72.11.72.41.01.0
Incentive Sensitization - Responses0.91.33.71.60.70.81.10.41.91.40.91.60.20.5
Incentive Sensitization - Breakpoint1.01.23.31.60.70.81.10.41.81.40.91.60.20.5
Sum of active levers in priming session hrs 5-60.10.10.20.20.10.20.10.10.50.50.40.4-0.1-0.1
Progressive ratio0.20.30.6-0.6-0.6-0.4-0.4-0.4-0.8-0.7-0.4-0.6-0.10.1
Food seeking constrained by brief footshock0.40.51.80.40.10.60.50.00.70.60.70.80.81.3
Seeking ratio, punishment vs. effort0.00.00.10.00.30.2-0.00.10.30.30.10.2-0.0-0.2
Retroperitoneal fat weight0.00.10.50.40.10.10.40.40.1-0.10.2-0.30.40.7
Reaction time number correct0.10.10.30.20.10.20.1-0.10.50.50.30.60.20.4
Reaction time mean minus median0.10.31.3-0.4-0.3-0.4-0.20.0-0.4-0.6-0.2-0.8-0.2-1.1
Reaction time mean minus median AUC0.10.21.0-0.2-0.7-0.5-0.2-0.50.2-0.3-0.2-0.3-0.5-1.0
Reaction time num false alarms0.20.20.7-0.3-0.2-0.5-0.5-0.3-0.5-0.4-0.8-0.3-0.8-0.4
Reaction time num false alarms AUC0.40.61.4-0.5-0.5-0.8-0.8-0.6-0.7-0.6-1.1-0.5-1.2-0.6
Reaction time trials correct on left0.10.10.30.20.10.20.1-0.10.50.50.30.60.20.4
Reaction time trials on left0.10.20.40.30.10.20.1-0.10.60.60.40.70.30.5
Reaction time mean0.20.40.80.50.70.70.70.90.40.30.90.10.6-0.4
Reaction time mean AUC0.30.40.90.50.70.70.70.90.40.31.00.10.7-0.4
Median of all reaction times0.40.51.30.60.90.90.81.00.50.51.10.30.7-0.1
Reaction time omissions1.31.94.31.60.61.11.40.42.11.81.61.70.91.2
Reaction time false alarm rate0.40.61.5-0.5-0.6-0.8-0.7-0.6-0.8-0.7-1.1-0.6-1.2-0.6
Reaction time premature initiation rate0.30.41.0-0.40.1-0.5-0.50.3-0.8-0.8-0.8-1.0-0.5-1.0
Reaction time premature initiations0.10.10.3-0.10.3-0.2-0.30.4-0.3-0.3-0.3-0.4-0.2-0.6
Std. dev. reaction times0.10.20.40.50.40.50.50.60.60.30.50.20.3-0.6
Reaction time trials completed0.10.20.40.30.10.20.1-0.10.60.60.40.70.30.5
Reaction time trials AUC0.10.20.50.30.20.30.20.10.60.60.40.70.40.6
Run reversals in cocaine runway, females1.01.02.31.21.00.61.41.50.90.51.40.10.8-0.2
Run reversals in cocaine runway, males1.31.32.5-1.3-1.1-1.1-1.1-0.8-1.2-1.6-1.1-1.6-0.6-1.0
Latency to leave start box in cocaine runway0.80.91.41.10.60.81.10.61.21.11.21.00.71.0
Latency to leave start box in cocaine runway, F1.72.02.51.51.11.41.41.01.51.51.61.51.21.5
Latency to leave start box in cocaine runway, M0.30.30.8-0.3-0.9-0.8-0.3-0.8-0.2-0.4-0.4-0.4-0.8-0.4
Std. dev. time between licks in bursts1.62.13.21.51.71.61.61.71.41.31.41.11.81.0
Total sessions with >9 infusions2.02.43.31.41.81.71.51.61.71.31.81.21.61.0
Short access day 1 total inactive lever presses0.10.10.70.00.40.2-0.10.20.10.10.10.1-0.3-0.8
Short access day 10 total inactive lever presses0.10.31.20.2-0.20.30.1-0.50.60.70.50.90.41.1
Short access day 1 total infusions3.24.36.92.02.62.32.12.32.01.92.21.72.11.1
Short access day 10 total infusions0.81.02.20.71.51.10.91.50.60.31.00.21.40.7
Short access total infusions2.43.05.11.62.31.91.72.11.61.31.81.22.11.3
Short access day 1 locomotion0.20.30.50.20.70.70.40.40.60.40.70.40.70.7
Short access day 10 total locomotion0.30.61.1-1.0-1.0-0.9-0.8-0.9-0.4-0.9-0.4-0.9-0.5-0.5
Short access total locomotion0.00.10.3-0.5-0.1-0.1-0.3-0.30.1-0.30.2-0.20.0-0.1
One hour access (0.3 mA shock)1.61.92.71.21.21.41.20.91.61.51.51.61.51.3
Compulsive drug intake1.92.25.5-1.5-2.3-1.7-1.5-2.2-1.0-1.1-1.0-0.9-1.5-0.9
One hour access (shock baseline)3.45.28.82.23.02.52.22.71.92.12.01.92.51.8
Social response proportion2.32.64.31.91.51.61.81.42.01.82.11.61.00.5
Social responses1.01.22.61.10.81.11.10.81.41.21.61.11.10.6
Social time0.60.92.5-0.6-1.2-1.0-0.9-1.5-0.3-0.1-0.80.1-1.6-0.7
Soleus weight0.61.82.5-1.6-1.5-1.5-1.4-1.5-1.2-1.5-1.2-1.3-0.9-0.5
Bone: stiffness0.10.10.6-0.1-0.1-0.2-0.3-0.2-0.5-0.1-0.8-0.1-0.40.2
Tibialis anterior weight6.421.728.1-4.8-4.7-5.0-5.0-4.3-5.2-4.6-5.3-4.4-4.4-3.1
Time to tail flick, vehicle, before self-admin0.20.31.20.40.80.00.51.10.1-0.20.1-0.40.3-0.6
Time to tail flick, vehicle, after self-admin0.20.31.40.50.40.40.40.5-0.20.3-0.30.40.31.2
Time to tail flick, test, before self-admin0.60.61.1-0.6-0.9-0.9-0.7-0.8-0.6-0.9-1.0-0.7-0.8-0.7
Time to tail flick, test, after self-admin1.61.73.21.41.01.21.51.01.71.31.81.21.10.5
Delta time to tail flick, vehicle, before/after SA0.40.31.70.4-0.30.30.0-0.50.10.6-0.30.9-0.11.3
Delta time to tail flick, test, before/after SA2.02.14.01.51.41.41.51.21.81.62.01.31.00.2
Tibia length0.71.94.3-1.3-1.9-1.4-1.5-2.1-0.9-1.0-1.4-0.6-1.6-0.5
Ambulatory time before self-admin0.50.81.6-0.8-0.4-0.8-0.7-0.1-1.1-1.2-0.9-1.3-0.6-1.1
Ambulatory time after self-admin0.40.41.2-0.60.1-0.3-0.30.6-1.0-0.9-0.3-1.1-0.0-0.8
Bone: tissue strength0.20.20.30.30.40.50.40.30.50.40.40.40.40.5
Total heroin consumption1.51.82.8-1.5-1.7-1.5-1.4-1.6-0.8-1.3-0.8-1.2-1.2-1.3
Bone: trabecular number0.61.01.51.21.11.11.21.01.01.11.21.00.40.5
Bone: trabecular spacing0.40.51.0-0.7-0.5-0.8-0.6-0.3-0.8-0.8-0.6-1.0-0.4-0.8
Bone: trabecular thickness0.40.50.9-0.7-0.7-0.6-0.8-0.8-0.8-0.6-1.0-0.4-0.8-0.1
Bone: trabecular tissue density0.81.21.6-1.2-1.2-1.1-1.2-1.3-1.0-1.0-1.1-0.8-1.0-0.6
Water consumed over 24 hours0.10.10.5-0.6-0.3-0.2-0.5-0.2-0.7-0.3-0.3-0.2-0.00.2
Number of responses in last shaping day1.21.33.10.51.71.50.81.7-0.20.50.50.41.51.1