Hub : Genes

Dio1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Dio1 0.06 0.03 1.0e-06 0.05 0.05 0.05 0.05 2.9e-06 6.2e-06 4.5e-06 6.9e-06
2 Liver gene expression Dio1 0.11 0.06 2.1e-08 0.05 0.03 0.03 0.04 4.3e-06 1.9e-04 1.3e-04 3.4e-05
3 BLA gene expression Dio1 0.22 0.1 1.2e-08 0.18 0.17 0.16 0.17 1.0e-09 2.9e-09 5.4e-09 1.6e-09
4 Eye gene expression Dio1 0.79 0.09 1.7e-09 0.34 0.33 0.46 0.5 3.7e-06 5.3e-06 2.1e-08 2.6e-09
5 IC gene expression Dio1 0.16 0.08 2.6e-05 0.1 0.08 0.08 0.09 8.5e-05 3.0e-04 4.3e-04 9.8e-05
6 PL gene expression Dio1 0.39 0.1 0.0e+00 0.38 0.41 0.41 0.41 1.8e-43 2.2e-47 1.5e-48 1.8e-48
7 Brain gene expression Dio1 0.04 0.03 7.4e-04 0.02 0.03 0.01 0.02 6.4e-03 8.1e-04 2.3e-02 2.4e-03
8 NAcc gene expression Dio1 0.11 0.06 4.7e-15 0.05 0.11 0.1 0.1 4.7e-08 5.2e-16 3.2e-14 1.9e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.73.0-0.81.01.41.71.21.41.51.2
Area under the delay curve1.01.11.81.3-0.1-1.2-1.1-1.3-1.1-1.0-0.7
BMI with tail0.51.64.3-0.9-2.1-0.5-1.2-0.7-1.1-1.3-1.6
BMI without tail0.20.72.5-1.5-1.60.3-0.20.30.40.3-0.5
Body weight0.31.23.1-0.7-1.7-0.8-1.5-0.7-0.7-0.6-1.3
Weight adjusted by age0.20.31.0-1.0-0.30.80.50.4-0.1-0.3-0.2
Bone surface0.10.30.6-0.10.50.50.70.10.50.80.4
Bone volume0.10.20.4-0.50.10.50.60.20.30.5-0.0
Breakpoint value in progressive ratio session0.00.00.10.30.4-0.2-0.0-0.1-0.2-0.10.1
Number of licking bursts0.40.61.00.30.1-0.9-0.6-0.9-1.0-1.0-1.0
Context. condit. distance diff. score2.02.53.1-1.51.01.71.71.71.71.81.4
Locomotion velocity, session 10.91.04.50.82.10.41.10.10.50.71.0
Locomotion distance, session 10.10.10.30.40.60.00.0-0.3-0.2-0.1-0.1
Locomotion velocity, session 20.91.05.20.82.30.21.1-0.00.30.50.7
Locomotion distance, session 20.40.61.30.3-1.1-0.4-0.6-0.9-0.8-0.6-1.1
Locomotion velocity, session 30.20.21.30.11.20.00.4-0.10.20.40.1
Locomotion distance, session 30.20.20.6-0.8-0.60.40.10.60.50.50.2
Stereotopy head waving bouts, day 30.91.11.71.10.6-1.2-0.9-1.3-1.2-1.0-0.9
Stereotopy head waving duration, day 30.60.71.31.01.2-0.9-0.4-1.0-0.8-0.6-0.5
Locomotion velocity, session 70.50.61.2-1.1-0.11.00.90.80.70.70.1
Locomotion distance, session 72.02.54.0-1.9-0.82.01.61.91.61.50.8
Stereotopy head waving bouts, day 71.21.33.51.81.9-1.3-0.5-1.2-0.6-0.30.2
Stereotopy head waving duration, day 71.01.23.51.71.9-1.3-0.5-1.1-0.6-0.40.1
Locomotion velocity, session 80.70.92.50.21.60.61.10.50.80.91.0
Locomotion distance, session 80.71.11.7-1.20.21.21.11.01.11.30.5
Degree of sensitization distance0.70.71.4-1.2-0.41.21.01.00.60.60.1
Degree of sensitization stereotypy0.80.81.91.41.3-1.2-0.5-1.0-0.5-0.30.0
Conditioned locomotion0.10.10.1-0.20.10.10.3-0.2-0.3-0.4-0.3
Cocaine response after cond. corrected0.50.63.7-0.6-1.90.2-0.5-0.0-0.2-0.2-0.8
Cocaine response after cond. not corrected0.60.74.3-0.8-2.10.2-0.50.0-0.1-0.0-0.8
Cocaine response before conditioning0.10.10.2-0.5-0.10.20.20.30.30.40.1
Saline control response0.30.40.8-0.2-0.60.40.30.70.80.90.7
Bone: connectivity density0.91.52.4-0.21.21.11.50.81.31.51.3
Bone: cortical apparent density1.52.03.70.21.71.11.91.11.41.31.8
Bone: cortical area0.30.52.1-0.8-1.40.0-0.6-0.0-0.2-0.1-0.9
Bone: cortical porosity2.02.13.61.70.9-1.9-1.3-1.9-1.5-1.2-0.9
Bone: cortical porosity3.43.76.42.51.3-2.5-1.7-2.5-1.9-1.5-0.9
Bone: cortical thickness0.91.53.9-0.9-2.0-0.3-1.1-0.5-1.1-1.1-1.8
Bone: cortical thickness0.40.51.3-0.8-1.1-0.1-0.6-0.2-0.6-0.6-1.0
Bone: cortical tissue density1.62.23.90.21.91.12.01.11.41.41.9
Condit. Reinf. active minus inactive responses0.40.51.1-1.0-0.90.80.40.70.60.60.1
Condit. Reinf. active-inactive response ratio0.50.51.7-1.3-0.80.80.30.80.50.6-0.1
Condit. Reinf. active responses0.40.51.5-0.2-1.2-0.4-0.7-0.4-0.6-0.7-0.9
Condit. Reinf. inactive responses1.11.31.91.2-0.5-1.3-1.1-1.3-1.2-1.4-1.0
Incentive salience index mean0.40.52.3-1.0-1.50.3-0.20.2-0.0-0.0-0.6
Condit. Reinf. lever presses0.40.62.4-0.8-1.5-0.1-0.6-0.1-0.3-0.3-0.9
Condit. Reinf. active minus inactive responses1.41.83.2-1.8-1.01.41.11.61.41.30.5
Condit. Reinf. active-inactive response ratio3.23.75.0-2.0-0.52.21.92.22.22.21.4
Condit. Reinf. active responses0.71.02.6-1.6-0.81.00.81.20.90.90.2
Condit. Reinf. inactive responses0.30.51.0-0.3-0.6-0.5-0.6-0.4-0.8-0.9-1.0
Condit. Reinf. lever presses0.20.30.5-0.1-0.40.40.50.50.70.70.6
Condit. Reinf. lever reinforcers received0.40.61.7-1.3-0.70.70.50.90.70.7-0.0
Conditioned reinforcement - actives0.50.83.2-1.4-1.8-0.1-0.70.60.20.2-0.3
Conditioned reinforcement - inactives0.20.30.50.6-0.1-0.7-0.7-0.7-0.7-0.5-0.3
Conditioned locomotion1.01.32.2-1.5-0.81.30.91.51.21.10.6
Patch foraging indifference point 0 sec0.10.20.8-0.4-0.90.3-0.00.10.30.4-0.0
Patch foraging indifference point AUC1.01.42.1-1.00.61.31.31.31.41.51.0
Delay disc. indifference point, 0s delay0.40.51.21.10.3-0.9-0.7-0.8-0.6-0.6-0.2
Delay disc. indifference point, 16s delay2.02.23.10.7-1.2-1.5-1.8-1.7-1.6-1.5-1.7
Delay disc. indifference point, 2s delay0.10.10.20.20.20.10.20.1-0.3-0.5-0.0
Delay disc. indifference point, 24s delay0.50.61.11.00.3-1.0-0.7-1.1-0.7-0.6-0.5
Delay disc. indifference point, 4s delay0.80.81.21.1-0.2-1.1-1.0-1.0-1.0-1.1-0.6
Delay disc. indifference point, 8s delay0.50.50.90.9-0.2-0.9-0.8-0.9-0.6-0.5-0.6
Indifference point function ln k0.20.40.80.1-0.9-0.5-0.7-0.7-0.6-0.5-0.6
Indifference point function log k0.20.40.80.1-0.9-0.5-0.7-0.7-0.6-0.5-0.6
Patch foraging total patch changes 0 sec0.10.10.7-0.3-0.80.20.00.10.40.40.1
Patch foraging total patch changes 12 sec0.60.81.40.71.00.61.00.50.91.01.2
Patch foraging total patch changes 18 sec0.40.61.5-0.7-0.51.20.90.90.70.70.4
Patch foraging total patch changes 24 sec0.40.71.3-0.1-1.1-0.6-0.9-0.6-0.9-1.0-1.0
Patch foraging total patch changes 6 sec0.10.20.5-0.2-0.70.3-0.00.20.40.60.1
Patch foraging time to switch 0 sec0.61.24.42.11.6-0.9-0.2-0.7-0.6-0.80.5
Patch foraging water rate 0 sec0.40.93.5-1.3-1.9-0.1-0.7-0.1-0.4-0.4-1.2
Patch foraging water rate 12 sec0.81.75.8-1.9-2.4-0.2-1.1-0.1-0.4-0.4-1.6
Patch foraging water rate 18 sec0.40.61.40.60.1-1.2-0.9-0.9-0.7-0.8-0.6
Patch foraging water rate 24 sec0.10.10.40.00.0-0.7-0.5-0.4-0.3-0.3-0.4
Patch foraging water rate 6 sec1.31.92.80.1-1.5-1.4-1.6-1.2-1.3-1.4-1.7
Seeking ratio, delayed vs. immediate footshock1.41.75.8-2.4-1.91.40.51.30.50.5-0.5
Distance traveled before self-admin1.31.75.3-2.3-0.31.61.21.31.01.10.0
Distance traveled after self-admin0.81.04.4-2.1-1.10.80.30.70.50.5-0.6
Extensor digitorum longus weight0.31.25.4-2.3-1.21.10.31.10.40.3-0.5
Bone: elastic displacement4.75.59.6-3.00.13.12.62.82.22.01.2
Bone: elastic work2.12.74.8-2.2-0.42.21.72.01.61.40.6
Bone: endosteal estimation0.61.32.6-0.60.41.11.01.21.51.61.3
Bone: endosteal perimeter0.10.20.40.50.3-0.00.10.10.50.60.6
Epididymis fat weight0.30.92.11.50.4-1.4-1.2-1.1-0.6-0.5-0.1
Delta time in closed arm before/after self-admin5.85.48.7-2.4-0.22.92.62.72.42.42.0
Delta time in open arm before/after self-admin1.81.83.21.7-0.0-1.8-1.5-1.4-1.2-1.3-0.8
Diff in mean of infusions in LGA sessions0.10.10.20.2-0.5-0.4-0.4-0.4-0.4-0.2-0.3
Delay discount exponential model param1.01.11.8-1.30.11.21.11.31.01.00.7
Extinction: sum of active levers before priming0.10.10.3-0.50.20.20.20.50.20.10.3
Active lever presses in extinction session 60.80.82.1-0.5-1.4-0.4-0.9-0.4-1.0-0.9-1.2
Bone: final force0.00.00.10.10.10.30.10.10.20.30.2
Bone: final moment0.00.00.1-0.1-0.10.40.10.10.20.30.1
Food consumed during 24 hour testing period0.81.12.20.8-1.3-1.2-1.5-1.0-0.7-0.7-0.9
Glucose0.10.21.0-1.0-0.30.50.20.60.20.2-0.0
Heart weight0.30.41.1-0.5-1.1-0.0-0.5-0.4-0.7-0.6-0.8
Delay discount hyperbolic model param1.01.12.0-1.40.01.21.01.21.01.10.6
Intermittent access intake day 1-15 change0.20.41.3-1.0-1.1-0.5-0.80.60.2-0.0-0.2
Intermittent access intake escalation0.20.41.2-0.8-1.1-0.7-0.90.4-0.0-0.2-0.3
Intermittent access intake escalation 20.30.31.0-0.1-0.5-1.0-1.00.1-0.1-0.2-0.1
Intermitt. access day 1 inactive lever presses0.10.51.8-1.2-1.30.4-0.20.2-0.10.0-0.7
Intermitt. access day 15 inactive lever presses0.10.20.30.2-0.6-0.2-0.3-0.4-0.5-0.4-0.5
Intermitt. access escalation Index0.10.10.30.5-0.1-0.2-0.3-0.6-0.3-0.4-0.3
Intermittent access day 1 total infusions0.30.51.31.20.6-0.6-0.3-1.0-0.7-0.5-0.1
Intermittent access day 15 total infusions0.30.40.90.4-0.4-0.9-1.0-0.5-0.7-0.7-0.4
Intermittent access terminal intake (last 3 days)0.00.00.1-0.0-0.0-0.3-0.30.20.00.00.2
Intermittent access total infusions0.10.20.60.80.3-0.5-0.3-0.3-0.3-0.20.2
Intermittent access day 1 locomotion0.20.21.11.00.4-0.2-0.0-0.6-0.4-0.20.2
Intermittent access day 15 total locomotion0.10.10.30.5-0.3-0.6-0.6-0.0-0.2-0.30.1
Intermittent access total locomotion0.10.10.60.80.2-0.3-0.2-0.2-0.1-0.00.4
Intermittent access standard deviation0.61.33.6-1.0-1.9-0.7-1.3-0.0-0.9-1.0-1.2
Left kidney weight1.67.528.3-3.8-5.3-0.1-2.20.4-1.1-1.3-3.1
Right kidney weight1.04.515.4-2.4-3.9-0.6-2.1-0.3-1.2-1.4-2.6
Cocaine induced anxiety0.20.20.6-0.6-0.60.80.40.40.2-0.2-0.3
Post-drug Anxiety0.20.30.7-0.4-0.80.50.1-0.2-0.4-0.6-0.7
Baseline Anxiety2.32.74.11.2-0.4-1.9-1.8-1.9-2.0-1.7-1.5
Tail length0.10.31.2-0.3-0.0-0.0-0.00.20.81.10.4
Length with tail0.10.20.8-0.5-0.9-0.3-0.7-0.00.20.5-0.2
Length without tail0.51.55.3-0.8-2.3-0.4-1.4-0.4-0.9-0.8-1.5
Times rat made contact with spout0.20.21.0-0.5-1.0-0.0-0.30.10.30.2-0.3
Lifetime Intake0.20.20.80.90.2-0.6-0.4-0.5-0.3-0.20.3
Liver weight, left0.00.10.2-0.30.10.40.30.20.10.00.1
Liver weight, right0.30.50.8-0.20.30.80.60.70.90.90.8
Locomotor activity0.71.12.0-1.3-0.81.30.91.41.00.70.6
Locomotor testing distance1.73.15.6-2.3-1.32.21.52.41.71.40.9
Locomotor testing rearing1.32.64.4-1.9-1.01.91.42.11.71.51.1
Locomotion in novel chamber2.63.35.6-0.0-2.4-1.5-2.2-1.3-1.8-1.9-2.3
Locomotion in novel chamber post-restriction0.30.61.00.2-0.1-0.7-0.8-1.0-0.8-0.7-1.0
Fecal boli incidents, locomotor time 10.10.10.20.5-0.4-0.3-0.4-0.5-0.2-0.1-0.1
Change in fecal boli incidents, locomotor task0.20.10.40.50.6-0.6-0.3-0.2-0.2-0.20.2
Time >=10cm from walls, locomotor time 12.12.33.4-0.91.31.61.81.31.61.71.6
Bouts of movement, locomotor time 10.91.03.92.00.7-1.1-0.8-1.1-0.6-0.50.1
Total resting periods, locomotor time 11.21.44.52.10.6-1.4-1.0-1.4-0.8-0.7-0.1
Rest time, locomotor task time 10.10.10.60.70.10.00.1-0.4-0.2-0.10.2
Distance moved, locomotor task time 10.20.20.7-0.90.70.10.20.60.40.40.0
Vertical activity count, locomotor time 10.10.20.7-0.8-0.4-0.4-0.50.3-0.2-0.3-0.6
Time >=10cm from walls, locomotor time 20.60.91.9-1.40.10.90.81.01.11.20.7
Bouts of movement, locomotor time 20.10.10.70.10.8-0.4-0.10.3-0.0-0.10.2
Total resting periods, locomotor time 20.10.10.60.20.8-0.4-0.10.2-0.1-0.20.2
Rest time, locomotor task time 20.50.72.21.50.2-0.6-0.4-0.9-0.8-1.1-0.3
Distance moved, locomotor task time 21.01.24.9-2.2-0.60.80.41.20.91.0-0.1
Vertical activity count, locomotor time 20.81.14.9-2.2-1.30.70.11.00.60.7-0.5
Light reinforcement 10.10.10.4-0.2-0.30.0-0.2-0.3-0.5-0.6-0.6
Light reinforcement 20.40.61.5-0.8-1.1-0.4-0.8-0.3-0.6-0.5-1.2
Bone: marrow area0.61.42.7-0.70.31.11.01.21.51.61.3
Bone: maximum diameter0.20.40.90.3-0.3-0.8-0.9-0.7-0.6-0.3-0.7
Bone: maximum force0.20.30.8-0.4-0.00.60.40.60.70.90.5
Bone: maximum moment0.20.40.8-0.6-0.20.70.40.60.70.90.4
Mean time between licks in bursts0.51.32.40.30.91.21.60.91.21.21.4
Mean num. licks in bursts0.40.71.2-0.9-1.10.80.20.90.90.90.5
Cd content in liver3.43.85.0-1.40.82.22.12.22.22.12.0
Co content in liver2.63.04.7-1.90.12.21.62.01.92.01.2
Cu content in liver3.33.95.9-1.7-0.42.42.12.42.22.01.8
Fe content in liver0.60.72.7-1.6-0.80.80.20.90.60.5-0.2
K content in liver0.20.20.3-0.4-0.50.40.20.60.40.30.3
Mg content in liver0.90.92.40.1-1.6-0.7-1.2-0.6-0.8-0.9-1.1
Mn content in liver0.30.30.6-0.50.50.60.60.80.40.40.6
Na content in liver0.80.91.4-0.80.21.21.21.10.91.00.7
Rb content in liver0.00.00.00.2-0.20.0-0.10.10.10.10.1
Se content in liver1.11.32.2-1.4-0.31.10.91.31.41.50.7
Sr content in liver0.80.71.0-1.0-0.01.00.81.00.80.80.6
Zn content in liver0.20.20.60.50.20.50.60.30.40.40.7
Bone: minimum diameter0.61.11.7-1.3-1.21.10.51.21.11.20.4
Time in familiar zone, hab. session 11.61.52.4-1.50.51.51.51.51.21.10.7
Time in novel zone, hab. session 10.50.51.10.10.10.50.50.60.91.01.0
Total zone transitions, hab. session 10.10.10.60.20.70.10.20.0-0.1-0.10.0
Total locomotion distance, hab. session 10.10.10.4-0.20.0-0.2-0.3-0.2-0.5-0.4-0.6
Locomotion velocity, hab. session 10.60.81.10.80.1-1.0-0.9-1.0-1.1-1.0-0.9
Time in familiar zone, hab. session 21.92.02.8-1.5-0.01.71.51.61.51.51.0
Time in novel zone, hab. session 20.10.10.30.60.1-0.2-0.3-0.2-0.2-0.20.1
Total zone transitions, hab. session 20.00.00.2-0.2-0.40.20.00.10.10.2-0.1
Total locomotion distance, hab. session 20.20.30.8-0.4-0.8-0.2-0.6-0.3-0.5-0.4-0.9
Locomotion velocity, hab. session 20.50.61.5-0.2-0.8-0.5-0.9-0.7-0.8-0.8-1.2
Novel to familiar place preference ratio0.70.82.10.1-1.5-0.6-1.0-0.6-0.8-1.0-0.9
Novelty place preference0.50.51.00.2-1.0-0.6-0.9-0.5-0.7-0.8-0.7
Time in novel zone, NPP test0.30.30.80.1-0.9-0.4-0.6-0.3-0.5-0.6-0.5
Total zone transitions, NPP test0.20.20.7-0.8-0.80.2-0.20.2-0.3-0.3-0.6
Total locomotion distance, NPP test0.30.51.0-0.9-1.0-0.2-0.6-0.1-0.5-0.5-1.0
Locomotion velocity, NPP test0.60.81.9-0.9-1.3-0.3-0.9-0.3-0.8-0.8-1.4
Intraocular pressure0.71.11.61.0-0.6-1.2-1.3-1.0-1.1-1.2-0.8
Delta distance traveled before/after self-admin1.21.32.30.5-1.4-1.3-1.5-1.1-1.0-1.1-1.2
Delta ambulatory time before/after self-admin0.91.12.00.5-1.2-1.2-1.4-0.9-0.9-1.1-1.0
Parametrial fat weight0.30.71.30.70.0-1.1-1.0-1.0-0.8-0.7-0.8
Pavlov. Cond. lever latency0.70.91.80.31.30.71.10.51.01.01.3
Pavlov. Cond. magazine entry latency0.10.10.40.60.30.00.20.00.30.30.7
Pavlov. Cond. change in total contacts0.10.10.30.20.0-0.5-0.3-0.4-0.4-0.3-0.3
Pavlov. Cond. index score0.10.10.4-0.0-0.6-0.3-0.4-0.2-0.4-0.3-0.4
Pavlov. Cond. latency score0.30.30.50.1-0.6-0.5-0.7-0.4-0.7-0.6-0.6
Pavlov. Cond. lever contacts0.60.71.3-0.2-1.1-0.6-0.9-0.5-0.9-0.9-1.2
Pavlov. Cond. magazine entry number0.10.10.3-0.6-0.40.1-0.10.10.0-0.1-0.5
Pavlov. Cond. intertrial magazine entries1.92.22.91.0-1.4-1.5-1.7-1.5-1.5-1.7-1.6
Pavlov. Cond. lever-magazine prob. diff.0.20.20.6-0.1-0.8-0.3-0.6-0.2-0.5-0.4-0.5
Pavlov. Cond. response bias0.00.00.1-0.2-0.30.20.10.20.10.20.1
Pavlov. Cond. lever latency0.10.21.0-0.31.00.20.30.10.00.10.0
Pavlov. Cond. magazine entry latency1.11.32.1-0.4-0.01.21.11.31.51.31.4
Pavlov. Cond. change in total contacts0.10.10.70.5-0.8-0.2-0.1-0.10.0-0.00.0
Pavlov. Cond. index score0.30.40.60.0-0.60.60.50.70.80.60.8
Pavlov. Cond. latency score0.30.30.5-0.1-0.60.50.50.60.70.60.7
Pavlov. Cond. lever contacts0.10.10.7-0.1-0.80.20.10.30.30.20.2
Pavlov. Cond. magazine entry number0.60.71.5-0.4-0.6-0.7-0.9-0.7-1.0-1.0-1.2
Pavlov. Cond. intertrial magazine entries0.30.50.80.70.7-0.6-0.2-0.8-0.8-0.9-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.50.90.0-0.60.70.60.81.00.80.9
Pavlov. Cond. response bias0.20.20.50.2-0.30.40.50.50.60.50.7
Time in closed arm before self-admin0.50.61.51.21.0-0.9-0.5-0.8-0.5-0.6-0.2
Time in closed arm after self-admin0.40.40.8-0.00.50.70.90.50.70.60.9
Time in open arm before self-admin1.11.22.7-1.7-0.61.31.01.40.91.00.5
Time in open arm after self-admin0.50.51.10.1-0.9-0.9-1.0-0.4-0.6-0.6-0.8
Bone: periosteal estimation0.20.30.7-0.9-0.70.50.00.50.60.80.1
Bone: periosteal perimeter0.00.00.2-0.2-0.4-0.0-0.20.00.10.2-0.2
Bone: post-yield work0.00.10.20.30.2-0.1-0.10.10.30.40.3
Progressive ratio test 1 active lever presses0.40.51.00.5-0.6-0.9-1.0-0.8-0.8-0.6-0.5
Progressive ratio test 1 breakpoint0.40.50.90.5-0.5-0.9-1.0-0.8-0.7-0.6-0.5
Progressive ratio test 1 inactive lever presses0.00.10.1-0.1-0.3-0.4-0.4-0.1-0.10.2-0.0
Progressive ratio test 2 active lever presses0.10.20.40.1-0.3-0.7-0.6-0.3-0.4-0.3-0.2
Progressive ratio test 2 breakpoint0.20.20.60.2-0.3-0.7-0.7-0.3-0.4-0.3-0.2
Progressive ratio test 2 inactive lever presses0.20.40.70.8-0.0-0.8-0.6-0.7-0.7-0.6-0.3
Incentive Sensitization - Responses0.60.81.91.00.1-1.4-1.1-0.9-0.8-0.8-0.4
Incentive Sensitization - Breakpoint0.40.61.40.80.0-1.2-0.9-0.7-0.7-0.7-0.3
Sum of active levers in priming session hrs 5-60.80.72.5-1.60.01.00.81.00.50.60.2
Progressive ratio1.32.03.00.8-0.7-1.5-1.6-1.4-1.7-1.7-1.5
Food seeking constrained by brief footshock2.12.64.70.52.11.11.51.11.71.92.2
Seeking ratio, punishment vs. effort4.76.79.8-0.72.12.52.92.43.03.13.1
Retroperitoneal fat weight0.31.13.31.80.8-1.2-0.9-1.1-0.8-0.8-0.0
Reaction time number correct0.00.10.20.10.4-0.3-0.00.10.30.30.3
Reaction time mean minus median0.20.52.31.5-0.4-0.4-0.4-0.8-0.7-0.7-0.1
Reaction time mean minus median AUC0.00.10.60.8-0.30.10.1-0.2-0.2-0.10.2
Reaction time num false alarms0.91.22.6-0.0-1.6-0.6-1.2-0.9-1.1-1.1-1.5
Reaction time num false alarms AUC1.01.64.6-0.3-2.1-0.6-1.3-0.8-1.1-1.1-1.7
Reaction time trials correct on left0.00.10.20.10.4-0.3-0.00.10.30.30.3
Reaction time trials on left0.00.10.20.10.4-0.4-0.10.00.20.20.3
Reaction time mean1.22.05.42.30.1-1.3-0.9-1.8-1.5-1.5-0.6
Reaction time mean AUC0.61.03.51.90.4-0.8-0.3-1.2-1.0-1.0-0.2
Median of all reaction times1.62.25.82.40.4-1.4-0.9-1.9-1.6-1.6-0.6
Reaction time omissions1.82.74.11.9-0.8-1.7-1.6-2.0-1.8-1.7-1.2
Reaction time false alarm rate1.11.55.1-0.5-2.3-0.2-1.1-0.6-1.1-1.1-1.7
Reaction time premature initiation rate0.30.40.8-0.10.00.60.60.70.90.70.7
Reaction time premature initiations0.30.51.10.10.40.50.60.81.10.91.0
Std. dev. reaction times0.20.51.61.3-0.6-0.4-0.4-0.8-0.6-0.6-0.2
Reaction time trials completed0.00.10.20.10.4-0.4-0.10.00.20.20.3
Reaction time trials AUC0.00.00.10.00.2-0.4-0.10.10.20.20.2
Run reversals in cocaine runway, females1.71.73.11.80.2-1.6-1.2-1.5-1.3-1.3-0.7
Run reversals in cocaine runway, males0.80.83.4-1.5-1.80.5-0.30.4-0.1-0.2-0.7
Latency to leave start box in cocaine runway0.40.40.7-0.1-0.7-0.5-0.7-0.7-0.8-0.7-0.9
Latency to leave start box in cocaine runway, F0.91.11.9-0.1-0.9-0.8-1.1-1.0-1.3-1.1-1.4
Latency to leave start box in cocaine runway, M0.10.10.20.20.10.20.20.10.30.30.4
Std. dev. time between licks in bursts0.40.62.31.11.50.00.7-0.10.20.20.8
Total sessions with >9 infusions0.60.71.91.40.2-1.2-0.9-0.9-0.7-0.40.1
Short access day 1 total inactive lever presses0.91.22.1-0.5-1.5-1.0-1.4-0.8-1.1-1.1-1.3
Short access day 10 total inactive lever presses0.10.20.8-0.9-0.60.2-0.00.30.10.2-0.4
Short access day 1 total infusions0.50.61.11.10.0-1.0-0.8-0.9-0.8-0.7-0.2
Short access day 10 total infusions0.20.20.40.70.2-0.6-0.5-0.6-0.5-0.4-0.1
Short access total infusions0.40.61.81.30.3-0.9-0.7-0.9-0.6-0.50.1
Short access day 1 locomotion0.10.21.00.0-1.0-0.2-0.5-0.1-0.1-0.1-0.0
Short access day 10 total locomotion0.91.72.81.0-0.8-1.6-1.7-1.5-1.4-1.2-1.1
Short access total locomotion0.10.10.40.60.4-0.2-0.1-0.10.10.20.5
One hour access (0.3 mA shock)0.20.30.80.20.40.20.40.60.60.60.9
Compulsive drug intake0.30.30.80.80.90.20.5-0.20.40.40.6
One hour access (shock baseline)0.20.21.0-0.6-1.0-0.1-0.40.3-0.3-0.3-0.3
Social response proportion0.10.10.50.70.30.10.3-0.10.0-0.00.3
Social responses0.50.61.60.11.30.40.90.60.80.70.9
Social time0.20.21.0-1.0-0.60.40.10.30.20.1-0.4
Soleus weight0.92.59.0-3.0-2.60.9-0.20.9-0.2-0.5-1.5
Bone: stiffness0.10.20.50.70.2-0.7-0.5-0.5-0.3-0.1-0.0
Tibialis anterior weight0.92.96.3-1.8-2.4-0.8-1.7-0.7-1.4-1.4-2.5
Time to tail flick, vehicle, before self-admin1.41.52.50.3-1.3-1.2-1.6-1.0-1.3-1.3-1.4
Time to tail flick, vehicle, after self-admin1.11.53.00.3-0.7-0.7-1.0-1.2-1.6-1.7-1.6
Time to tail flick, test, before self-admin0.50.51.6-0.7-1.30.1-0.5-0.1-0.4-0.8-0.9
Time to tail flick, test, after self-admin0.50.51.3-0.5-0.90.2-0.2-0.4-0.7-0.8-1.1
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.5-0.20.30.1-0.2-0.5-0.6-0.7
Delta time to tail flick, test, before/after SA0.20.20.40.60.1-0.3-0.2-0.6-0.6-0.4-0.4
Tibia length0.41.01.50.9-1.2-0.9-1.0-1.2-1.0-0.9-0.7
Ambulatory time before self-admin1.72.56.1-2.5-0.22.01.61.71.41.50.4
Ambulatory time after self-admin0.60.72.7-1.6-0.90.70.30.80.60.5-0.2
Bone: tissue strength1.41.42.3-0.70.41.21.11.41.51.41.3
Total heroin consumption0.20.20.50.70.7-0.40.0-0.3-0.4-0.40.1
Bone: trabecular number1.72.74.5-1.01.01.72.11.61.91.91.7
Bone: trabecular spacing2.02.74.30.5-1.0-1.5-1.8-1.5-2.0-2.1-2.0
Bone: trabecular thickness1.01.32.2-0.60.41.31.51.21.31.31.1
Bone: trabecular tissue density0.10.10.5-0.30.7-0.10.30.2-0.1-0.2-0.1
Water consumed over 24 hours1.21.63.2-1.8-1.41.20.71.41.41.40.5
Number of responses in last shaping day0.70.83.1-1.4-1.80.5-0.10.5-0.1-0.2-0.7